TOP 10 Medical News Stories

Fri May 01 – 10 Stories of The Day!

1 May, 2020 | 03:58h | UTC

 

1 – Care for Breastfeeding Women – Centers for Disease Control and Prevention

 

2 – CO-RADS – A categorical CT assessment scheme for patients with suspected COVID-19: definition and evaluation – Radiology

 

3 – Classification of the cutaneous manifestations of COVID‐19: a rapid prospective nationwide consensus study in Spain with 375 cases – British Journal of Dermatology

Related: Journal articles on coronavirus with relevance for skin diseases and dermatology – Centre of Evidence Based Dermatology, University of Nottingham AND Characterization of acute acro-ischemic lesions in non-hospitalized patients: a case series of 132 patients during the COVID-19 outbreak – Journal of the American Academy of Dermatology

Great atlas with the different cutaneous manifestations of Covid-19.

 

4 – Changes in contact patterns shape the dynamics of the COVID-19 outbreak in China – Science

 

5 – An analysis of SARS-CoV-2 viral load by patient age – German Research network Zoonotic Infectious Diseases

Commentary: Expert reaction to a preprint looking at the amount of virus from those with COVID-19 in different age groups – Science Media Centre

 

6 – Antibody responses to SARS-CoV-2 in patients with COVID-19 – Nature Medicine

Commentary: Expert reaction to antibody response in COVID-19 patients – Science Media Centre

 

7 – Population flow drives spatio-temporal distribution of COVID-19 in China – Nature

Commentary: Researchers devise new model to track COVID-19’s spread – Yale News

 

8 – COVID‐19 Coagulopathy in Caucasian patients – British Journal of Haematology

Commentary: Blood clotting a significant cause of death in patients with COVID-19 – RCSI University of Medicine and Health Sciences

 

9 – Treatment Considerations for COVID-19: A Critical Review of the Evidence (or Lack Thereof) – Mayo Clinic Proceedings

 

10 – Coronavirus Disease (COVID-19) Updates / 01 May 2020 Edition

01 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Thu April 30 – 10 Stories of The Day!

30 Apr, 2020 | 04:34h | UTC

 

1 – Remdesivir in adults with severe COVID-19: a randomised, double-blind, placebo-controlled, multicentre trial – The Lancet

Commentaries: First randomized trial of remdesivir suggests antiviral drug is not associated with significant clinical benefits, more research needed – The Lancet AND Expert reaction to trial of remdesivir in adults – Science Media Centre

 

2 – NIH clinical trial shows Remdesivir accelerates recovery from advanced COVID-19 – National Institutes of Health

Commentaries: Hopes rise on coronavirus drug remdesivir – Nature AND The COVID-19 research news rollercoaster is running again: STAT News + Gilead’s remdesivir – HealthNews Review

 

3 – Pooling of samples for testing for SARS-CoV-2 in asymptomatic people – The Lancet Infectious Diseases AND Commentary: Virologists show that sample pooling can massively increase coronavirus testing capacity – Saarland University

Related Preprint Study: Smart Pooled sample Testing for COVID-19: A Possible Solution for Sparsity of Test Kits – medRxiv AND Commentary: ‘Smart sample pooling’ for COVID-19 could solve test kit shortage problem – News Medical

 

4 – Gender Differences in Patients With COVID-19: Focus on Severity and Mortality – Frontiers in Public Health

News Release: COVID-19 study shows that men have over double the death rate of women – Frontiers

 

5 – Out-of-Hospital Cardiac Arrest during the Covid-19 Outbreak in Italy – New England Journal of Medicine

 

6 – Audio Interview: Loosening Covid-19 Restrictions – New England Journal of Medicine

 

7 – Covid-19 — A Reminder to Reason – New England Journal of Medicine

 

8 – COVID-19 and its implications for thrombosis and anticoagulation – Blood

 

9 – Science Has an Ugly, Complicated Dark Side. And the Coronavirus Is Bringing It Out – Mother Jones

 

10 – Coronavirus Disease (COVID-19) Updates / 30 April 2020 Edition

30 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Wed April 29 – 10 Stories of The Day!

29 Apr, 2020 | 05:23h | UTC

 

1 – Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young – New England Journal of Medicine

 

2 – Pandemic Science Out of Control – Issues in Science and Technology

 

3 – What policy makers need to know about COVID-19 protective immunity – The Lancet

Related: What Covid-19 antibody tests say — and don’t say — about immunity – Vox AND The False Hope of Antibody Tests – The Atlantic AND What Antibody Studies Can Tell You — and More Importantly, What They Can’t – ProPublica AND What if immunity to covid-19 doesn’t last? – MIT Technology Review AND Beware of Antibody-based COVID-19 “Immunity Passports” – Scientific American AND Coronavirus immunity: Can you catch it twice? – BBC

 

4 – Atypical presentation of COVID-19 in young infants – The Lancet

“In the pandemic context, infants younger than 3 months with isolated fever should be tested for SARS-CoV-2. “

 

5 – Covid-19: concerns grow over inflammatory syndrome emerging in children – The BMJ

Related: UK says some children have died from syndrome linked to COVID-19 – Reuters

 

6 – Characterization of acute acro-ischemic lesions in non-hospitalized patients: a case series of 132 patients during the COVID-19 outbreak – Journal of the American Academy of Dermatology

See also: Journal articles on coronavirus with relevance for skin diseases and dermatology – Centre of Evidence Based Dermatology, University of Nottingham AND From ‘COVID Toes’ to Hives, These Are the Skin Conditions Dermatologists Think Could Be Signs of Coronavirus – TIME

 

7 – Why don’t some coronavirus patients sense their alarmingly low oxygen levels? – Science

 

8 – Patients with cancer appear more vulnerable to SARS-COV-2: a multi-center study during the COVID-19 outbreak – Cancer Discovery

Commentaries: COVID-19 Increases Overall Risk of Death, Complications in Patients With Cancer, Study Shows – AJMC AND Patients with blood and lung cancers are three times more at risk of dying of coronavirus than people with other tumors, study finds – Daily Mail AND Coronavirus: Cancer patients nearly three times more likely to die of Covid-19, study says – Independent

 

9 – Lung pathology of COVID-19: is AFOP in play? – PulmCrit

 

10 – Coronavirus Disease (COVID-19) Updates / 29 April 2020 Edition

29 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Tue April 28 – 10 Stories of The Day!

28 Apr, 2020 | 04:49h | UTC

 

1 – Infectious Diseases Society of America Guidelines on Infection Prevention in Patients with Suspected or Known COVID-19

See also: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Infection

 

2 – Diagnosis, Prevention, and Treatment of Thromboembolic Complications in COVID-19: Report of the National Institute for Public Health of the Netherlands – Radiology

 

3 – International Expert Consensus Statement on Chest Imaging in Pediatric COVID-19 Patient Management: Imaging Findings, Imaging Study Reporting and Imaging Study Recommendations – Radiology

Commentary: Recommendations issued for imaging use in pediatric COVID-19 – MedicalXpress

 

4 – Exposure to a Surrogate Measure of Contamination From Simulated Patients by Emergency Department Personnel Wearing Personal Protective Equipment – JAMA

Editorial: COVID-19 and Risks Posed to Personnel During Endotracheal Intubation – JAMA

 

5 – Aerodynamic analysis of SARS-CoV-2 in two Wuhan hospitals – Nature

Commentaries: SARS-CoV-2 Found in Aerosols in Hospital Staff Areas, Public Places – NEJM Journal Watch AND Coronavirus Lingers in Air of Crowded Spaces, New Study Finds – Bloomberg AND Expert reaction to a Nature paper presenting evidence for the presence of SARS-CoV-2 RNA in the air – Science Media Centre

 

6 – Pseudoscience and COVID-19 — we’ve had enough already – Nature

 

7 – Which epidemiologist do you believe? – UnHeard

“The debate about lockdown is not a contest between good and evil”

 

8 – Scientists who express different views on Covid-19 should be heard, not demonized – STAT

 

9 – Twitter-based learning for continuing medical education? A new perspective for a paradigm shift in medical education, accelerated by COVID-19 – European Heart Journal

Related: How Twitter is Changing Medical Research (texts on the subject)

 

10 – Coronavirus Disease (COVID-19) Updates / 28 April 2020 Edition

28 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Fri April 24 – 10 Stories of The Day!

24 Apr, 2020 | 11:14h | UTC

 

1 – COVID-19 rapid guideline: acute myocardial injury – National Institute for Health and Care Excellence

Related Guidelines: ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic – European Society of Cardiology AND Management of Acute Myocardial Infarction During the COVID-19 Pandemic – Journal of the American Academy of Cardiology

 

2 – Respiratory Support in Novel Coronavirus Disease (COVID-19) Patients, with a Focus on Resource-Limited Settings – The American Society of Tropical Medicine and Hygiene

 

3 – Association of Renin-Angiotensin System Inhibitors With Severity or Risk of Death in Patients With Hypertension Hospitalized for Coronavirus Disease 2019 (COVID-19) Infection in Wuhan, China – JAMA Cardiology

Commentary: Drugs for high blood pressure don’t appear to make COVID-19 worse – Science News

Related Study: Association of Inpatient Use of Angiotensin Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers with Mortality Among Patients With Hypertension Hospitalized With COVID-19 – Circulation Research

 

4 – New York Antibody Study Estimates 14% of Residents in State and 20% in NYC Have Had Covid-19

• NY releases figures estimating 14 percent in state, 20 percent in NYC have had COVID-19 – The Hill
• New York antibody study estimates 13.9% of residents have had the coronavirus, Gov. Cuomo says – CNBC
• 1 in 5 New Yorkers May Have Had Covid-19, Antibody Tests Suggest – The New York Times
• Coronavirus Has Infected A 5th Of New York City, Testing Suggests – NPR
• New York Finds Virus Marker in 13.9%, Suggesting Wide Spread – Bloomberg

 

5 – Health care workers seek to flatten COVID-19’s ‘second curve’—their rising mental anguish – Science

Related: Understanding and Addressing Sources of Anxiety Among Health Care Professionals During the COVID-19 Pandemic – JAMA AND Mental health outcomes among front and second line health workers associated with the COVID-19 pandemic in Italy. – medRxiv AND Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019 – JAMA Network Open

“there’s a second curve we’re going to have to flatten: the mental health consequences of the pandemic.”

 

6 – Against pandemic research exceptionalism – Science

“Crises are no excuse for lowering scientific standards.”

 

7 – In Defense of Evidence-Based Medicine for the Treatment of COVID-19 ARDS – Annals of the American Thoracic Society

 

8 – A Skeptic’s Guide To Ecologic Studies During A Pandemic – Forbes

Related: BCG Against Coronavirus: Less Hype And More Evidence, Please – Forbes

 

9 – New data on Gilead’s remdesivir, released by accident, show no benefit for coronavirus patients. Company still sees reason for hope – STAT

Related: Remdesivir in covid-19 – The BMJ AND What’s Happening With Remdesivir? – Science Translational Medicine AND Slow down your giddyup on Gilead news – Health News Review

 

10 – Coronavirus Disease (COVID-19) Updates / 24 April 2020 Edition

24 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Mon April 27 – 10 Stories of The Day!

26 Apr, 2020 | 21:42h | UTC

 

1 – “Immunity passports” in the context of COVID-19 – World Health Organization

Commentaries: WHO: ‘No Evidence’ That COVID-19 Antibodies Protect From Potential Re-infection – TIME AND WHO warns against coronavirus immunity passports – The Guardian AND ‘No Evidence’ Yet That Recovered COVID-19 Patients Are Immune, WHO Says – NPR AND “No evidence” that recovered COVID-19 patients cannot be reinfected: WHO – Reuters

 

2 – A real-time dashboard of clinical trials for COVID-19 – The Lancet

See the platform: COVID-19 clinical trials registry

 

3 – Management of COVID-19 Respiratory Distress – JAMA

Related Podcast: Coronavirus (COVID-19) Update: Ventilatory Management for COVID-Related Respiratory Failure – JAMA

 

4 – Mild or Moderate Covid-19 – New England Journal of Medicine

 

5 – Transforming ORs into ICUs – New England Journal of Medicine

 

6 – Asymptomatic Transmission, the Achilles’ Heel of Current Strategies to Control Covid-19 – New England Journal of Medicine

 

7 – Presymptomatic SARS-CoV-2 Infections and Transmission in a Skilled Nursing Facility – New England Journal of Medicine

Commentary: Expert reaction to study looking at presymptomatic SARS-CoV-2 coronavirus transmission in a nursing home in the US – Science Media Centre

 

8 – When Should Schools Reopen? – Center for Global Development

 

9 – Universal Do-Not-Resuscitate Orders, Social Worth, and Life-Years: Opposing Discriminatory Approaches to the Allocation of Resources During the COVID-19 Pandemic and Other Health System Catastrophes – Annals of Internal Medicine

Related Debate: Is it Wrong to Prioritize Younger Patients with Covid-19?

 

10 – Coronavirus Disease (COVID-19) Updates / 27 April 2020 Edition

27 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Thu April 23 – 10 Stories of The Day!

23 Apr, 2020 | 09:45h | UTC

 

1 – Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area – JAMA

Commentary: Almost Every Hospitalized Coronavirus Patient Has Another Underlying Health Issue, According to a Study of New York Patients – TIME

 

2 – Alterations in Smell or Taste in Mildly Symptomatic Outpatients With SARS-CoV-2 Infection – JAMA

Related: Study Validates Loss of Smell and Taste as Symptoms of Covid-19

 

3 – Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection in Children and Adolescents: A Systematic Review – JAMA Pediatrics

Commentaries: Most kids with coronavirus usually recover within two weeks, JAMA study finds – CNBC AND Young people at lower risk for COVID-19, can still transmit the virus – UPI AND Expert reaction to systematic review of COVID-19 in children – Science Media Centre

 

4 – COVID-19 in Children in the United States: Intensive Care Admissions, Estimated Total Infected, and Projected Numbers of Severe Pediatric Cases in 2020 – Journal of Public Health Management and Practice

Commentaries: The coronavirus has probably infected far more children in the US than thought, a study says – Business Insider AND COVID-19 possibly striking more children than expected – University of South Florida

 

5 – Saliva is more sensitive for SARS-CoV-2 detection in COVID-19 patients than nasopharyngeal swabs – medRxiv

 

6 – Remdesivir in covid-19 – The BMJ

Related: What’s Happening With Remdesivir? – Science Translational Medicine AND Slow down your giddyup on Gilead news – Health News Review

 

7 – A Call for Rational Intensive Care in the Era of COVID-19 – American Journal of Respiratory Cell and Molecular Biology

 

8 – Estimated population wide benefits and risks in China of lowering sodium through potassium enriched salt substitution: modelling study – The BMJ

Commentaries: Salt substitution could prevent almost half a million deaths from CVD in China – George Institute for Global Health AND Embracing salt substitutes could help China prevent 450K CVD deaths per year – Cardiovascular Business

 

9 – Low-cost, easy-to-build non-invasive pressure support ventilator for under-resourced regions: open source hardware description, performance and feasibility testing – European Respiratory Journal

Commentary: Low-cost, easy-to-build ventilator performs similarly to high-quality commercial device – European Lung Foundation

 

10 – Coronavirus Disease (COVID-19) Updates / 23 April 2020 Edition

23 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Wed April 22 – 10 Stories of The Day!

22 Apr, 2020 | 09:05h | UTC

 

1 – NIH Coronavirus Disease 2019 (COVID-19)
Treatment Guidelines – National Institutes of Health

News Release: Expert U.S. panel develops NIH treatment guidelines for COVID-19

Commentary: New U.S. Treatment Guidelines for Covid-19 Don’t See Much Progress – The New York Times

 

2 – ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic – European Society of Cardiology

 

3 – Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19 – medRxiv

Commentaries: Study finds no benefit, higher death rate in patients taking hydroxychloroquine for Covid-19 – CNN AND More deaths, no benefit from malaria drug in VA virus study – Associated Press

 

4 – Antibody surveys suggesting vast undercount of coronavirus infections may be unreliable – Science

 

5 – What tests could potentially be used for the screening, diagnosis and monitoring of COVID-19 and what are their advantages and disadvantages? – CEBM University of Oxford

 

6 – Viral load dynamics and disease severity in patients infected with SARS-CoV-2 in Zhejiang province, China, January-March 2020: retrospective cohort study – The BMJ

 

7 – Endocrinology in the time of COVID-19: Management of adrenal insufficiency – European Journal of Endocrinology

 

8 – Richard Lehman’s covid-19 reviews, 20 April 2020 – The BMJ Opinion

“In this weekly round-up, Richard Lehman looks at a personal selection of articles of relevance to clinicians dealing with covid-19”.

 

9 – Editorial: Modelling the pandemic – The BMJ

Related: Predictive Mathematical Models of the COVID-19 Pandemic (other commentaries on the subject)

“Over-reliance on modelling leads to missteps and blind spots in our response”

 

10 – Coronavirus Disease (COVID-19) Updates / 22 April 2020 Edition

22 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Tue April 21 – 10 Stories of The Day!

21 Apr, 2020 | 08:24h | UTC

 

1 – Management of Acute Myocardial Infarction During the COVID-19 Pandemic – Journal of the American Academy of Cardiology

Commentaries: ACC, SCAI, ACEP Release Consensus Statement on Management of AMI Patients During COVID-19 – American College of Cardiology

 

2 – Description and Proposed Management of the Acute COVID-19 Cardiovascular Syndrome – Circulation

 

3 – Therapeutic strategies for critically ill patients with COVID-19 – Annals of Intensive Care

 

4 – Perspectives on the Pandemic | Dr. John Ioannidis Update: 4.17.20

Related (from Dr. John Ioannidis): Antibody Tests Suggest that Coronavirus Infections Vastly Exceed Official Counts AND Study: Population-level COVID-19 Mortality Risk

 

5 – Timed & titrated use of steroid in COVID-19? – PulmCrit

 

6 – Sweden Says Controversial Virus Strategy Proving Effective – Bloomberg

Related: Coronavirus in Europe: Is it a myth to say it’s life as normal in Sweden amid COVID-19 pandemic? – Euronews AND Sweden’s government has tried a risky coronavirus strategy. It could backfire – Vox AND Sweden has nearly 10 times the number of COVID-19-related deaths than its Nordic neighbors. Here’s where they went wrong – Business Insider

 

7 – Important Information on the Use of Serological (Antibody) Tests for COVID-19 – Letter to Health Care Providers – U.S. Food & Drug Administration

See also: Coronavirus (COVID-19) Update: Serological Test Validation and Education Efforts – U.S. Food & Drug Administration

Commentary: FDA Warns Providers About Limits of SARS-CoV-2 Antibody Tests – NEJM Journal Watch

 

8 – D‐dimer levels on admission to predict in‐hospital mortality in patients with Covid‐19 – Journal of Thrombosis and Haemostasis

Related: D-dimer is Associated with Severity of Coronavirus Disease 2019: A Pooled Analysis – Thrombosis and Haemostasis

 

9 – Thrombocytopenia and Its Association with Mortality in Patients with COVID‐19 – Journal of Thrombosis and Haemostasis

Related: Thrombocytopenia is associated with severe coronavirus disease 2019 (COVID-19) infections: A meta-analysis – Clinica Chimica Acta

 

10 – Coronavirus Disease (COVID-19) Updates / 21 April 2020 Edition

21 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Mon April 20 – 10 Stories of The Day!

20 Apr, 2020 | 00:29h | UTC

 

1 – Antibody tests suggest that coronavirus infections vastly exceed official counts – Nature

See original preprint study: COVID-19 Antibody Seroprevalence in Santa Clara County, California – medRxiv

Author interview: Dr. John Ioannidis Announces Results of COVID-19 Serology Study (video)

Other commentaries: Far more people may have been infected by coronavirus in one California county, study estimates – CNN AND The number of coronavirus infections in Santa Clara, California may be up to 85 times higher than testing shows, according to new research – Business Insider AND Up to 4% of Silicon Valley is already infected with coronavirus – MIT Technology Review

 

2 – The Promise and Peril of Antibody Testing for COVID-19 – JAMA

See also: Will antibody tests for the coronavirus really change everything? – Nature AND Antibody Test, Seen as Key to Reopening Country, Does Not Yet Deliver – The New York Times AND With Broad, Random Tests for Antibodies, Germany Seeks Path out of Lockdown

 

3 – How does coronavirus kill? Clinicians trace a ferocious rampage through the body, from brain to toes – Science

 

4 – The Science Underlying COVID-19: Implications for the Cardiovascular System – Circulation

 

5 – COVID-19 and Thrombotic or Thromboembolic Disease: Implications for Prevention, Antithrombotic Therapy, and Follow-up – Journal of the American College of Cardiology

Commentary: JACC Paper Outlines Implications, Considerations For Thrombotic Disease Patients During COVID-19 Pandemic – American College of Cardiology

 

6 – Priorities for Cath labs in the COVID-19 tsunami: Roberto Ferrari and co-authors present a procedure to follow subsequent to the outbreak in Italy – European Heart Journal

Commentary: Priorities for Cath Labs in the COVID-19 Tsunami – American College of Cardiology

Related: Reperfusion of STEMI in the COVID-19 Era – Business as Usual? – Circulation AND As COVID-19 Spreads, US Cath Labs Ponder Fibrinolytics for STEMI – TCTMD

 

7 – Disruptive Modifications to Cardiac Critical Care Delivery During the Covid-19 Pandemic: An International Perspective – Journal of the American College of Cardiology

 

8 – What’s Happening With Remdesivir? – Science Translational Medicine

See also: Slow down your giddyup on Gilead news – Health News Review

 

9 – Impact assessment of non-pharmaceutical interventions against coronavirus disease 2019 and influenza in Hong Kong: an observational study – The Lancet Public Health

Commentary: Study examines how Hong Kong managed first wave of COVID-19 without resorting to complete lockdown – The Lancet AND How Hong Kong dodged a major coronavirus outbreak without resorting to a complete lockdown using a combination of targeted isolation and social distancing – Daily Mail AND Expert reaction to paper assessing the impact of non- pharmaceutical interventions against COVID-19 in Hong Kong – Science Media Centre

 

10 – Coronavirus Disease (COVID-19) Updates / 20 April 2020 Edition

20 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Fri April 17 – 10 Stories of The Day!

17 Apr, 2020 | 02:27h | UTC

 

1 – Hydroxychloroquine fails first meaningful RCT – PulmCrit

Original Study: Hydroxychloroquine for Covid-19: No Benefit in New Open-label, Randomized Trial

Related Commentary: Hydroxychloroquine in the management of critically ill patients with COVID-19: the need for an evidence base – The Lancet Respiratory Medicine

 

2 – Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19 – Journal of Thrombosis and Haemostasis

We congratulate the authors for this significant contribution to the understanding of this disease. 

 

3 – Coronavirus: Nine in 10 dying have existing illness – BBC

Original Report: Deaths involving COVID-19, England and Wales: deaths occurring in March 2020 – Office for National Statistics

 

4 – Key Strategies to Prepare for COVID-19 in Long-term Care Facilities (LTCFs) – Centers for Disease Control and Prevention

 

5 – Estimating the Maximum Capacity of COVID-19 Cases Manageable per Day Given a Health Care System’s Constrained Resources – Annals of Internal Medicine

Editorial: Pandemic Surge Models in the Time of Severe Acute Respiratory Syndrome Coronavirus-2: Wrong or Useful? – Annals of Internal Medicine

 

6 – Predictive Mathematical Models of the COVID-19 Pandemic: Underlying Principles and Value of Projections – JAMA

Related: The Mathematics of Predicting the Course of the Coronavirus – Wired AND Mathematics of life and death: How disease models shape national shutdowns and other pandemic policies – Science AND How to model a pandemic – The Conversation AND Coronavirus exposes the problems and pitfalls of modelling – The Guardian AND Systematic review and critical appraisal of prediction models for diagnosis and prognosis of COVID-19 infection – medRxiv AND Modelling the models – CEBM University of Oxford

 

7 – These European Countries Are Slowly Lifting Coronavirus Lockdowns. Here’s What That Looks Like – TIME

Related: When to re-open the economy – Medium AND Strategic preparedness and response plan for the new coronavirus – World Health Organization AND Study: Some Social Distance May Need to Continue Until 2022 AND Ending coronavirus lockdowns will be a dangerous process of trial and error – Science AND ‘Suppress and lift’: Hong Kong and Singapore say they have a coronavirus strategy that works – Science AND Opinions on Lifting Coronavirus Pandemic Lockdowns (opinions and report) AND Scott Gottlieb on how, and when, to end social distancing – Vox AND No country has beaten the coronavirus yet – Vox

 

8 – Innovation and Transformation in the Response to Covid-19: Seven Areas Where Clinicians Need to Lead – NEJM Catalyst

 

9 – Chest CT and Coronavirus Disease (COVID-19): A Critical Review of the Literature to Date – American Journal of Roentgenology

Commentary: AJR review of COVID-19 studies cautions against chest CT for coronavirus diagnosis – American Roentgen Ray Society

 

10 – Coronavirus Disease (COVID-19) Updates / 17 April 2020 Edition

17 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Thu April 16 – 10 Stories of The Day!

16 Apr, 2020 | 03:00h | UTC

 

1 – Visualizing Speech-Generated Oral Fluid Droplets with Laser Light Scattering – New England Journal of Medicine

Commentaries: Droplets and Aerosols in the Transmission of SARS-CoV-2 – New England Journal of Medicine AND Simply speaking could transmit coronavirus, new study suggests – STAT

 

2 – Audio Interview: Caring for Patients with Covid-19 – New England Journal of Medicine

 

3 – Neurologic Features in Severe SARS-CoV-2 Infection – New England Journal of Medicine

Related Study: Neurologic Manifestations Common in Hospitalized Patients with Covid-19 (study and commentaries)

 

4 – Death from Covid-19 of 23 Health Care Workers in China – New England Journal of Medicine

 

5 – COVID-19: the case for health-care worker screening to prevent hospital transmission – The Lancet

 

6 – Temporal dynamics in viral shedding and transmissibility of COVID-19 – Nature Medicine

Commentaries: People might be most infectious with coronavirus before they show symptoms, study suggests – CNN AND Expert reaction to a study looking at the timing of SARS-CoV-2 transmission – Science Media Centre

 

7 – News Release: NIH study validates decontamination methods for re-use of N95 respirators – NIH News Releases

Original Study: [Preprint] Assessment of N95 respirator decontamination and re-use for SARS-CoV-2 – medRxiv

 

8 – Evidence Based Management Guideline for the COVID-19 Pandemic – Review article – International Journal of Surgery

 

9 – Rates of Co-infection Between SARS-CoV-2 and Other Respiratory Pathogens – JAMA

 

10 – Coronavirus Disease (COVID-19) Updates / 16 April 2020 Edition

16 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Wed April 15 – 10 Stories of The Day!

15 Apr, 2020 | 03:51h | UTC

 

1 – Pharmacologic Management of Chronic Obstructive Pulmonary Disease: An Official American Thoracic Society Clinical Practice Guideline

Commentary: New COPD Guidelines Issued – NEJM Journal Watch

 

2 – Projecting the transmission dynamics of SARS-CoV-2 through the postpandemic period – Science

Commentaries: Coronavirus distancing may need to continue until 2022, say experts – The Guardian AND Harvard Researchers Say Some Social Distancing May Be Needed Into 2022 – Bloomberg AND Researchers Say Social Distancing To Prevent Coronavirus May Need To Continue Until 2022 – Forbes AND Some social distancing may be needed into 2022 to keep coronavirus in check, new study says – STAT

 

3 – Ending coronavirus lockdowns will be a dangerous process of trial and error – Science

Related: ‘Suppress and lift’: Hong Kong and Singapore say they have a coronavirus strategy that works – Science AND Opinions on Lifting Coronavirus Pandemic Lockdowns (opinions and report) AND Scott Gottlieb on how, and when, to end social distancing – Vox

 

4 – [Preprint] Hydroxychloroquine in patients with COVID-19: an open-label, randomized, controlled trial – medRxiv

See also just published observational study (Preprint): No evidence of clinical efficacy of hydroxychloroquine in patients hospitalized for COVID-19 infection with oxygen requirement: results of a study using routinely collected data to emulate a target trial – medRxiv

 

5 – Medically-Necessary, Time-Sensitive Procedures: A Scoring System to Ethically and Efficiently Manage Resource Scarcity and Provider Risk During the COVID-19 Pandemic – Journal of the American College of Surgeons

News Release: Scoring system empowers surgery departments to prioritize medically necessary operations – American College of Surgeons

 

6 – Coronavirus (COVID-19) Update: FDA Issues Emergency Use Authorization to Decontaminate Millions of N95 Respirators – U.S. Food & Drug Administration

Commentary: FDA clears N95 decontamination process that could clean up to 4 million masks per day – Tech Crunch

 

7 – Basing Respiratory Management of Coronavirus on Physiological Principles – American Journal of Respiratory and Critical Care Medicine

 

8 – COVID-19 estimation updates: What’s new for April 13, 2020 – Institute for Health Metrics and Evaluation

See also: IHME | COVID-19 Projections Tool Tutorial (video) AND IHME COVID-19 Projections Tool

See related article criticizing the model: Caution Warranted: Using the Institute for Health Metrics and Evaluation Model for Predicting the Course of the COVID-19 Pandemic – Annals of Internal Medicine

 

9 – CEBM Oxford COVID-19 Evidence Updates:

Hydroxychloroquine for COVID-19: What do the clinical trials tell us?

“Current data do not support the use of hydroxychloroquine for prophylaxis or treatment of COVID-19.”

How can pandemic spreads be contained in care homes?

Editor’s commentary: Rapid reviews of PPE – an update

“When will it be over?”: An introduction to viral reproduction numbers, R0 and Re

 

10 – Coronavirus Disease (COVID-19) Updates / 15 April 2020 Edition

15 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Tue April 14 – 10 Stories of The Day!

14 Apr, 2020 | 03:08h | UTC

 

1 – Diagnostic Testing for Severe Acute Respiratory Syndrome–Related Coronavirus-2: A Narrative Review – Annals of Internal Medicine

 

2 – Pharmacologic Treatments for Coronavirus Disease 2019 (COVID-19): A Review – JAMA

 

3 – New York City Coronavirus (COVID-19) Update – JAMA

 

4 – Universal Screening for SARS-CoV-2 in Women Admitted for Delivery – New England Journal of Medicine

Commentary: Universal Screening for SARS-CoV-2 at Delivery Could Identify Many Asymptomatic Women – NEJM Journal Watch

“29 of the 33 patients who were positive for SARS-CoV-2 at admission (87.9%) had no symptoms of Covid-19 at presentation”

 

5 – Ethics in the Time of Coronavirus: Recommendations in the COVID-19 Pandemic – Journal of the American College of Surgeons

 

6 – Association of chemosensory dysfunction and Covid‐19 in patients presenting with influenza‐like symptoms – International Forum of Allergy & Rhinology

Commentary: Loss of smell and taste validated as COVID-19 symptoms in patients with high recovery rate – University of California

 

7 – Management of inflammatory bowel disease patients in the COVID-19 pandemic era: a Brazilian tertiary referral center guidance – Clinics

Related: AGA Clinical Practice Update on Management of Inflammatory Bowel Disease During the COVID-19 Pandemic: Expert Commentary – Gastroenterology AND Management of Patients with Crohn’s Disease and Ulcerative Colitis During the COVID-19 Pandemic: Results of an International Meeting – Gastroenterology

 

8 – Face Masks Against COVID-19: An Evidence Review – Preprints

Related Analysis: Face Masks for the Public During the Covid-19 Crisis

 

9 – IDSA’s COVID-19 Treatment Guidelines Highlight Difficulty of “Don’t Just Do Something, Stand There” – HIV and ID Observations Blog

See Original Guideline: Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19

 

10 – Coronavirus Disease (COVID-19) Updates / 14 April 2020 Edition

14 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Mon April 13 – 10 Stories of The Day!

13 Apr, 2020 | 00:31h | UTC

 

1 – Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Infection

 

2 – Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China – JAMA Neurology

Editorial: The Spectrum of Neurologic Disease in the Severe Acute Respiratory Syndrome Coronavirus 2 Pandemic Infection: Neurologists Move to the Frontlines

Commentaries: 40% of people with severe COVID-19 experience neurological complications – UPI AND AND Expert reaction to paper on neurological manifestations of patients hospitalised with COVID-19 in Wuhan, China – Science Media Centre

Related: Preparing a neurology department for SARS-CoV-2 (COVID-19): Early experiences at Columbia University Irving Medical Center and the New York Presbyterian Hospital in New York City – Neurology

 

3 – Compassionate Use of Remdesivir for Patients with Severe Covid-19 – New England Journal of Medicine

Commentaries: PulmCrit – Eleven reasons the NEJM paper on remdesivir reveals nothing AND Expert reaction to a study about compassionate use of remdesivir for patients with severe COVID-19 – Science Media Centre AND What Do the New Remdesivir Data Mean? – Science Translational Medicine

 

4 – Incidence of thrombotic complications in critically ill ICU patients with COVID-19 – Thrombosis Research

Related Observational Studies: Prevalence of venous thromboembolism in patients with severe novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis AND Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy – Journal of Thrombosis and Haemostasis AND Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis

 

5 – D-dimer cutoffs to predict thrombosis in COVID-19 – PulmCrit

Note: this link is not an endorsement of the algorithm.

Related Guidance: Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 – Thrombosis UK AND ISTH interim guidance on recognition and management of coagulopathy – Journal of Thrombosis and Haemostasis

 

6 – Optimizing Medication Management during the COVID-19 Pandemic: Implementation Guide for Post-Acute and Long-Term Care – University of Maryland School of Pharmacy

 

7 – Mechanical Ventilators Adapted from BiPAP machines?

Modified Sleep Apnea Machines May Ease the Ventilator Crunch – Wired

Mechanical ventilators based on a simple modification of CPAP and BiPAP machines – News Medical

A NYC hospital has figured out how to turn sleep apnea machines it got from Elon Musk into ventilators for coronavirus patients – Business Insider

Turning sleep apnea machines into ventilators – Berkley Engineering

See instructions and protocols developed by Mount Sinai Health System: Repurposing bi-level ventilators for use with intubated patients while minimizing risk to health care works during insufficient supply of conventional ventilation for patients with COVID-19

We want to learn more about this interesting initiative!

 

8 – Studies: Obesity Increases the Risk of Complications in Patients with Covid-19

1 – High prevalence of obesity in severe acute respiratory syndrome coronavirus‐2 (SARS‐CoV‐2) requiring invasive mechanical ventilation – Obesity

2 – Obesity in patients younger than 60 years is a risk factor for Covid-19 hospital admission – Clinical Infectious Diseases AND Commentary: In New York, obesity appears to raise COVID-19 risk – CIDRAP

 

9 – Studies: Diabetes Increases the Risk of Complications in Patients with Covid-19

1 – Prevalence and impact of diabetes among people infected with SARS-CoV-2 – Journal of Endocrinological Investigation AND Commentary: Diabetes Could Increase Severity of COVID-19, Including Risk of ICU Admission and Death – MedicalResearch.com

2 – Evidence Reviews: Diabetes and risks from COVID-19 – CEBM University of Oxford AND Managing diabetes during the COVID-19 pandemic – CEBM University of Oxford

 

10 – Coronavirus Disease (COVID-19) Updates / 13 April 2020 Edition

13 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Studies: Diabetes Increases the Risk of Complications in Patients with Covid-19

13 Apr, 2020 | 00:12h | UTC

1 – Prevalence and impact of diabetes among people infected with SARS-CoV-2 – Journal of Endocrinological Investigation AND Commentary: Diabetes Could Increase Severity of COVID-19, Including Risk of ICU Admission and Death – MedicalResearch.com

2 – Evidence Reviews: Diabetes and risks from COVID-19 – CEBM University of Oxford AND Managing diabetes during the COVID-19 pandemic – CEBM University of Oxford

 

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Fri April 10 – 10 Stories of The Day!

10 Apr, 2020 | 03:24h | UTC

 

1 – News Release: NICE publishes new COVID-19 guidelines on cystic fibrosis, chronic obstructive pulmonary disease (COPD) and dermatological conditions – National Institute for Health and Care Excellence

See New COVID-19 Rapid Guidelines: Community-based care of patients with chronic obstructive pulmonary disease (COPD) AND Cystic fibrosis AND Dermatological conditions treated with drugs affecting the immune response

See Other COVID-19 Rapid Guidelines: Severe asthma AND Managing suspected or confirmed pneumonia in adults in the community AND Rheumatological autoimmune, inflammatory and metabolic bone disorders AND Managing symptoms (including at the end of life) in the community AND Critical care in adults AND Hematopoietic stem cell transplantation AND Dialysis service delivery AND Delivery of radiotherapy AND Delivery of systemic anticancer treatments

 

2 – Interim Guidance for Basic and Advanced Life Support in Adults, Children, and Neonates With Suspected or Confirmed COVID-19: From the Emergency Cardiovascular Care Committee and Get With the Guidelines®-Resuscitation Adult and Pediatric Task Forces of the American Heart Association in Collaboration with the American Academy of Pediatrics, American Association for Respiratory Care, American College of Emergency Physicians, The Society of Critical Care Anesthesiologists, and American Society of Anesthesiologists: Supporting Organizations: American Association of Critical Care Nurses and National EMS Physicians – Circulation

News Release: Interim CPR guidelines address challenges of providing resuscitation during COVID-19 pandemic – American Heart Association

 

3 – Safety at the Time of the COVID-19 Pandemic: How to Keep our Oncology Patients and Healthcare Workers Safe – Journal of the National Comprehensive Cancer Network

News Release: JNCCN: Improving COVID-19 safety for cancer patients and healthcare providers – National Comprehensive Cancer Network

 

4 – Implementing Safety Practices for Critical Infrastructure Workers Who May Have Had Exposure to a Person with Suspected or Confirmed COVID-19 – Centers for Disease Control and Prevention

Commentary: White House Announces New Guidance For How Critical Employees Can Return To Work – NPR

 

5 – Caring for patients with pain during the COVID-19 pandemic: Consensus recommendations from an international expert panel – Anaesthesia

 

6 – Children’s Story Books Released to Help Children Cope with COVID-19

1 – News Release: Children’s story book released to help children and young people cope with COVID-19 – World Health Organization AND Book 1: My Hero is You, How kids can fight COVID-19

2 – News Releases: Hans and the Gruffalo? LSHTM supporting children’s COVID-19 education – London School of Hygiene & Tropical Medicine AND Released today: a free information book explaining the coronavirus to children, illustrated by Gruffalo illustrator Axel Scheffler – Nosy Crow AND Book 2: Coronavirus: A Book for Children

 

7 – ST-segment Elevation, Myocardial Injury, and Suspected or Confirmed COVID-19 Patients: Diagnostic and Treatment Uncertainties – Mayo Clinic Proceedings

News Release: Mayo Clinic experts offer guidance on treating COVID-19 patients with signs of acute heart attack – Mayo Clinic

 

8 – Gastrointestinal Manifestations of SARS-CoV-2 Infection and Virus Load in Fecal Samples from the Hong Kong Cohort and Systematic Review and Meta-analysis – Gastroenterology

Commentary: Gastrointestinal Aspects of COVID-19 – NEJM Journal Watch

 

9 – Managing the supportive care needs of those affected by COVID-19 – European Respiratory Journal

 

10 – Coronavirus Disease (COVID-19) Updates / 10 April 2020 Edition

10 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Thu April 09 – 10 Stories of The Day!

9 Apr, 2020 | 03:57h | UTC

 

1 – Coronavirus Q&A with Anthony Fauci, MD – JAMA

 

2 – Interview with Dr. Eric Rubin and Dr. Lindsey Baden on emerging tools in the fight against Covid-19. – New England Journal of Medicine

 

3 – Quarantine alone or in combination with other public health measures to control COVID‐19: a rapid review – Cochrane Library

Commentary: How effective is quarantine alone or in combination with other public health measures to control coronavirus (COVID-19)? – Cochrane Library

 

4 – The COVID-19 Coronavirus Disease May Be Twice As Contagious As We Thought – Forbes

Original Study: High Contagiousness and Rapid Spread of Severe Acute Respiratory Syndrome Coronavirus 2 – CDC Emerging Infectious Diseases

 

5 – Chloroquine and hydroxychloroquine in covid-19 – Tue BMJ

“Use of these drugs is premature and potentially harmful”

 

6 – Considerations for Drug Interactions on QTc in Exploratory COVID-19 (Coronavirus Disease 2019) Treatment – Circulation

News Release: Caution recommended on COVID-19 treatment with hydroxychloroquine and azithromycin for patients with cardiovascular disease – American Heart Association

Commentaries: Medical groups urge caution when using hydroxychloroquine, azithromycin to treat COVID-19 patients with CVD – Cardiovascular Business AND AHA, ACC, HRS Caution Use of COVID-19 Therapies Hydroxychloroquine and Azithromycin in Cardiac Patients – DAIC

 

7 – Safety considerations with chloroquine, hydroxychloroquine and azithromycin in the management of SARS-CoV-2 infection – Canadian Medical Association Journal

Commentary: Potential harms of chloroquine, hydroxychloroquine and azithromycin for treating COVID-19 – Canadian Medical Association Journal

 

8 – [Preprint] Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters – medRxiv

Related perspectives from the same author:

Video: Perspectives on the Pandemic with Dr. John Ioannidis

Podcast: Be it resolved, we are making high-stakes decisions about the COVID-19 pandemic without reliable data. – Munk Debates Podcast

Editorial: Coronavirus disease 2019: the harms of exaggerated information and non‐evidence‐based measures – European Journal of Clinical Investigation

Opinion Piece: A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data – STAT

 

9 – [Preprint] Neutralizing antibody responses to SARS-CoV-2 in a COVID-19 recovered patient cohort and their implications – medRxiv

Commentaries: expert reaction to preprint (not a published paper) on antibody responses to the COVID-19 virus (SARS-CoV-2) in a group of recovered people in Shanghai – Science Media Centre AND Covid-19 Antibody Update for April 8 – Science Translational Medicine AND Coronavirus: low antibody levels raise questions about reinfection risk – South China Morning Post

 

10 – Coronavirus Disease (COVID-19) Updates / 09 April 2020 Edition

09 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Wed April 08 – 10 Stories of The Day!

8 Apr, 2020 | 01:38h | UTC

 

1 – Intensive care management of coronavirus disease 2019 (COVID-19): challenges and recommendations – The Lancet Respiratory Medicine

Commentary: Understanding pathways to death in patients with COVID-19 – The Lancet Respiratory Medicine

 

2 – COVID-19 Clinical Update – JAMA

 

3 – Advice on the use of masks in the context of COVID-19 – World Health Organization

Commentary: Expert reaction to new WHO advice on use of facemasks in the context of COVID-19 – Science Media Centre

 

4 – State of the World’s Nursing Report – 2020 – World Health Organization

Commentary: Six Million More Nurses Needed Ensure Health for All by 2030, Says New WHO Report – Health Policy Watch AND WHO and partners call for urgent investment in nurses – International Council of Nurses

Editorial: The status of nursing and midwifery in the world – The Lancet

 

5 – Prediction models for diagnosis and prognosis of covid-19 infection: systematic review and critical appraisal – The BMJ

Commentary: Expert reaction to a systematic review of prediction models for diagnosis and prognosis of COVID-19 infection – Science Media Centre

 

6 – New research examines wastewater to detect community spread of Covid-19 – STAT

Original Article: SARS-CoV-2 titers in wastewater are higher than expected from clinically confirmed cases – medRxiv

 

7 – The Role of Chest Imaging in Patient Management during the COVID-19 Pandemic: A Multinational Consensus Statement from the Fleischner Society

Commentary: RSNA publishes Fleischner Society statement on chest imaging and COVID-19 – Radiological Society of North America

 

8 – US Public Concerns About the COVID-19 Pandemic From Results of a Survey Given via Social Media – JAMA Internal Medicine

Commentaries: Social Media Survey Reveals Concerns About Childcare, Lost Wages and Finding Sanitizer – MedicalResearch AND More than 95% of Americans made lifestyle changes for COVID-19 – UPI

 

9 – 2019 Update of the Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA–EDTA) recommendations for the management of lupus nephritis – Annals of Rheumatic Diseases

Commentary: EULAR, ERA–EDTA issue guidelines for managing lupus nephritis – Medicine Matters

Related Guidelines: Consensus of the Brazilian Society of Rheumatology for the diagnosis, management and treatment of lupus nephritis (free) AND 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus (free) AND 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus (free) AND Clinical Practice Guidelines for the Treatment of Systemic Lupus Erythematosus by the Mexican College of Rheumatology (free) AND The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus (free) AND Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus (free PDF)

Related Reviews: Update on Lupus Nephritis – Clinical Journal of the American Society of Nephrology (free) AND Immunosuppressive Treatment for Proliferative Lupus Nephritis – Cochrane Library (free) AND Induction and Maintenance Immunosuppression Treatment of Proliferative Lupus Nephritis: A Network Meta-analysis of Randomized Trials. – American Journal of Kidney Diseases (free)

 

10 – Coronavirus Disease (COVID-19) Updates / 08 April 2020 Edition

08 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Tue April 07 – 10 Stories of The Day!

7 Apr, 2020 | 04:41h | UTC

 

1 – COVID‐19: Interim Guidance on Management Pending Empirical Evidence. From an American Thoracic Society‐led International Task Force

Commentary: ATS publishes new guidance on COVID-19 management – American Thoracic Society

 

2 – Management of Infants Born to Mothers with COVID-19 – American Academy of Pediatrics

News Release: AAP issues guidance on infants born to mothers with suspected or confirmed COVID-19 – American Academy of Pediatrics

FAQs: Management of Infants Born to Mothers with Suspected or Confirmed COVID-19 – American Academy of Pediatrics

Commentary: Policy statement outlines recommendations on management of infants born to mothers with COVID-19 – 2 Minute Medicine

 

3 –  Consensus guidelines for managing the airway in children with COVID-19 – Intensive Care Society

 

4 – Editorial: Cardiopulmonary Resuscitation after Hospital Admission with Covid-19 – The BMJ

“This pandemic has changed the risk-benefit balance for CPR: from “there is no harm in trying” to “there is little benefit to the patient, and potentially significant harm to staff.””

 

5 – Effectiveness of Surgical and Cotton Masks in Blocking SARS–CoV-2: A Controlled Comparison in 4 Patients – Annals of Internal Medicine

Commentary: Neither surgical nor cotton masks effectively filter SARS COV-2 – American College of Physicians

 

6 – Opinions on Lifting Coronavirus Pandemic Lockdowns

• How Will We Know When It’s Time to Reopen the Nation? – The New York Times
• Lockdown Can’t Last Forever. Here’s How to Lift It. – The New York Times
• When Can We Lift the Coronavirus Pandemic Restrictions? Not Before Taking These Steps – Scientific American

 

7 – Medical Masks vs N95 Respirators for Preventing COVID‐19 in Health Care Workers: A Systematic Review and Meta‐Analysis of Randomized Trials – Influenza

Commentary: Surgical masks likely good for most COVID-19 treatment – McMaster University

 

8 – Observational Studies: Countries with Universal BCG Vaccination Policy May Have Reduced Mortality from COVID-19

[Preprint] Differential COVID-19-attributable mortality and BCG vaccine use in countries – medRxiv

[Preprint] Association of BCG vaccination policy with prevalence and mortality of COVID-19 – medRxiv

See also: [Preprint] Observational Study: Countries with Universal BCG Vaccination Policy May Have Reduced Morbidity and Mortality for COVID-19 (study and commentaries)

 

9 – Coronavirus Disease 2019 in Children — United States, February 12–April 2, 2020 – Centers for Disease Control and Prevention

Commentaries: U.S. Children With COVID-19 Less Likely To Be Hospitalized Than Adults – NPR AND Why Children Seem to Be Less Affected By the Coronavirus – TIME

 

10 – Coronavirus Disease (COVID-19) Updates / 07 April 2020 Edition

07 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Mon April 06 – 10 Stories of The Day!

6 Apr, 2020 | 02:00h | UTC

1 – NICE Publishes new COVID-19 Guidelines

News Release: NICE publishes new COVID-19 guidelines on severe asthma, pneumonia, rheumatological disorders and symptom management – National Institute for Health and Care Excellence

• COVID-19 rapid guideline: severe asthma
• COVID-19 rapid guideline: managing suspected or confirmed pneumonia in adults in the community
• COVID-19 rapid guideline: rheumatological autoimmune, inflammatory and metabolic bone disorders
• COVID-19 rapid guideline: managing symptoms (including at the end of life) in the community

See other recent NICE Guidelines on COVID-19: COVID-19 rapid guideline: critical care in adults AND COVID-19 rapid guideline: haematopoietic stem cell transplantation AND COVID-19 rapid guideline: dialysis service delivery AND COVID-19 rapid guideline: delivery of radiotherapy AND COVID-19 rapid guideline: delivery of systemic anticancer treatments

 

2 – Recommendation Regarding the Use of Cloth Face Coverings, Especially in Areas of Significant Community-Based Transmission – Centers – Centers for Disease Control and Prevention

Commentaries: The CDC Now Recommends Americans Wear Face Masks – Wired AND Everyone should wear face ‘masks’ in public, CDC now recommends – Live Science AND CDC Now Recommends Americans Consider Wearing Cloth Face Coverings In Public – NPR AND The CDC now recommends everyone use cloth masks in public – Vox AND The CDC is recommending that people wear face coverings or cloth masks if they go out in public – Business Insider

“CDC recommends wearing cloth face coverings in public settings where other social distancing measures are difficult to maintain (e.g., grocery stores and pharmacies) especially in areas of significant community-based transmission.”

 

3 – Use of Cloth Face Coverings to Help Slow the Spread of COVID-19 – Centers for Disease Control and Prevention

Commentary: What’s the Best Material for a Mask? – The New York Times

 

4 – Respiratory virus shedding in exhaled breath and efficacy of face masks – Nature

Commentaries: Why wear face masks in public? Here’s what the research shows – The Conversation AND The new coronavirus might spread when people talk, but scientists say masks can help – The Telegraph AND Wearing surgical masks in public could help slow COVID-19 pandemic’s advance – University of Maryland

Related: Stability of SARS-CoV-2 in different environmental conditions – National Geographic

 

5 – COVID-19: Thrombosis, Coagulopathy and Disseminated Intravascular Coagulation

Guideline: Practical guidance for the prevention of thrombosis and management of coagulopathy and disseminated intravascular coagulation of patients infected with COVID-19 – Thrombosis UK

Observational Studies: Anticoagulant treatment is associated with decreased mortality in severe coronavirus disease 2019 patients with coagulopathy – Journal of Thrombosis and Haemostasis AND Abnormal Coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia – Journal of Thrombosis and Haemostasis (free PDF)

Q & A: COVID-19 and Coagulopathy: Frequently Asked Questions – American Society of Hematology

 

6 – Editorial: COVID-19 pneumonia: different respiratory treatment for different phenotypes? – Intensive Care Medicine

Related: Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome – American Journal of Respiratory and Critical Care Medicine

 

7 – The FDA-approved Drug Ivermectin inhibits the replication of SARS-CoV-2 in vitro – Antiviral Research

Commentary: Possible coronavirus drug identified by Australian scientists – Monash University

 

8 – No Evidence of Rapid Antiviral Clearance or Clinical Benefit with the Combination of Hydroxychloroquine and Azithromycin in Patients with Severe COVID-19 Infection – Médecine et Maladies Infectieuses

 

9 – Coronavirus Disease 2019 (COVID-19) Infection and Renin Angiotensin System Blockers – JAMA

Related: The Dilemma of Coronavirus Disease 2019, Aging, and Cardiovascular Disease: Insights From Cardiovascular Aging Science – JAMA Cardiology AND Controversies of renin–angiotensin system inhibition during the COVID-19 pandemic – Nature Reviews Nephrology

 

10 – Coronavirus Disease (COVID-19) Updates / 06 April 2020 Edition

06 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Fri April 03 – 10 Stories of The Day!

3 Apr, 2020 | 04:23h | UTC

 

1 – Temporary Emergency Guidance to US Stroke Centers During the COVID-19 Pandemic – American Heart Association / American Stroke Association

News Release: Interim guidance issued on stroke care during COVID-19 pandemic – American Heart Association

 

2 – Interim Guidance for Healthcare Providers Caring for Pediatric Patients to Reduce COVID-19 transmission – American Heart Association

News Release: Interim guidance for pediatric resuscitation care to reduce COVID-19 transmission – American Heart Association

Commentary: How to provide emergency cardiovascular care, including CPR, for children with COVID-19 – Cardiovascular Business

 

3 – Care of patients with liver disease during the COVID-19 pandemic: EASL-ESCMID Position Paper – European Association for the Study of the Liver (EASL)

News Release: Patients with advanced liver disease and transplant recipients require specific care during COVID-19 – European Association for the Study of the Liver (EASL)

 

4 – Covid-19 Does Not Lead to a “Typical” Acute Respiratory Distress Syndrome – American Journal of Respiratory and Critical Care Medicine

“After considering that, all we can do ventilating these patients is “buying time” with minimum additional damage: the lowest possible PEEP and gentle ventilation. We need to be patient.”

 

5 – Correlation between universal BCG vaccination policy and reduced morbidity and mortality for COVID-19: an epidemiological study – medRxiv

Commentaries: Universal BCG vaccination and protection against COVID-19: critique of an ecological study – Nature Microbiology Community AND A Vaccine From The 1920s Is Now Being Tested For Use Against The Coronavirus Pandemic – Forbes AND Nations with Mandatory TB Vaccines Show Fewer Coronavirus Deaths

 

6 – COVID-19: infection prevention and control – Public Health England

 

7 – COVID-19 Contact Tracing Apps

• COVID-19 contact tracing apps: 8 privacy questions governments should ask – Imperial College London
• In Germany, High Hopes For New COVID-19 Contact Tracing App That Protects Privacy – NPR
• Covid-19 spreads too fast for traditional contact tracing. New digital tools could help – STAT
• Quantifying SARS-CoV-2 transmission suggests epidemic control with digital contact tracing – Science

 

8 – How Hospitals Can Protect Frontline Healthcare Workers From COVID-19 – Medium

 

9 – Complete GUIDE to Lung Ultrasound in COVID-19 (Coronavirus) Patients – POCUS 101

Related: Proposal for international standardization of the use of lung ultrasound for COVID‐19 patients; a simple, quantitative, reproducible method – Journal of Ultrasound in Medicine AND Findings of lung ultrasonography of novel corona virus pneumonia during the 2019–2020 epidemic – Intensive Care Medicine AND Can Lung US Help Critical Care Clinicians in the Early Diagnosis of Novel Coronavirus (COVID-19) Pneumonia? – Radiology AND Point-of-Care Lung Ultrasound findings in novel coronavirus disease-19 pnemoniae: a case report and potential applications during COVID-19 outbreak – European Review for Medical and Pharmacological Sciences AND ACEP Guideline on COVID-19: Ultrasound Machine and Transducer Cleaning

 

10 – Coronavirus Disease (COVID-19) Updates / 03 April 2020 Edition

03 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Thu April 02 – 10 Stories of The Day!

2 Apr, 2020 | 04:29h | UTC

 

1 – Ethical guidance published for frontline staff dealing with pandemic – Royal College of Physicians

Related: An Ethicist on How to Make Impossible Decisions – The Atlantic

 

2 – Presymptomatic Transmission of SARS-CoV-2 — Singapore, January 23–March 16, 2020 – CDC Morbidity and Mortality Weekly Report

Commentaries: Coronavirus can spread one to three days before symptoms appear: CDC study – Reuters AND CDC Director warns 25 percent of COVID-19 cases may present no symptoms – New Atlas AND SARS-CoV-2 Readily Shed Early in Infection, Transmissible Before Symptoms Emerge – NEJM Journal Watch

Related: Yes, You Can Spread Coronavirus Even If You Don’t Have Symptoms – Self AND Infected but Feeling Fine: The Unwitting Coronavirus Spreaders – The New York Times AND COVID-19: Undocumented Infections are the Infection Source for 79% of Documented Cases

 

3 – Decontamination and Reuse of Filtering Facepiece Respirators using Contingency and Crisis Capacity Strategies – Centers for Disease Control and Prevention

 

4 – Virological assessment of hospitalized patients with COVID-2019 – Nature

Commentaries: People with coronavirus may be most infectious in the first week of symptoms – MIT Technology Review AND Expert reaction to paper on ‘shedding’ of SARS-CoV-2 virus in 9 patients with COVID-19 – Science Media Centre

 

5 – Video: Coronavirus (COVID-19) Update: Critical Care Management – JAMA

 

6 – Use of Hydroxychloroquine and Chloroquine During the COVID-19 Pandemic: What Every Clinician Should Know – Annals of Internal Medicine

 

7 – In patients of COVID-19, what are the symptoms and clinical features of mild and moderate cases? – CEBM University of Oxford

See also: Other Reviews at Oxford COVID-19 Evidence Service

 

8 – Editorial: Ten Weeks to Crush the Curve – New England Journal of Medicine

 

9 – Audio Interview: Lessons from Covid-19 Hotspots – New England Journal of Medicine

 

10 – Coronavirus Disease (COVID-19) Updates / 02 April 2020 Edition

02 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Wed April 01 – 10 Stories of The Day!

1 Apr, 2020 | 05:58h | UTC

 

1 – Pandemic palliative care: beyond ventilators and saving lives – Canadian Medical Association Journal

Commentary: A COVID-19 palliative care pandemic plan: An essential tool – Canadian Medical Association Journal

Related: The Importance of Addressing Advance Care Planning and Decisions About Do-Not-Resuscitate Orders During Novel Coronavirus 2019 (COVID-19) – JAMA AND Covid-19: The role of palliative care had to be adapted to manage this “ultra-emergency” – The BMJ Opinion AND COVID-19: decision making and palliative care – Swiss Medical Weekly AND COVID-19 pandemic: palliative care for elderly and frail patients at home and in residential and nursing homes – Swiss Medical Weekly AND End-of-life care in the Emergency Department for the patient imminently dying of a highly transmissible acute respiratory infection (such as COVID-19) – Canadian Journal of Emergency Medicine

 

2 – More Opinions on the Use of Facemasks by the Population

Article: COVID-19 epidemic: disentangling the re-emerging controversy about medical facemasks from an epidemiological perspective – International Journal of Epidemiology

Perspectives: CDC considering recommending general public wear face coverings in public – The Washington Post AND Wear a face mask if you feel it’s necessary, but know it won’t necessarily help – The Globe and Mail AND It’s Time to Face Facts, America: Masks Work – Wired AND Should We All Be Wearing Masks In Public? Health Experts Revisit The Question – NPR AND Should I Make My Own Mask? – The New York Times

 

3 – ‘Panic Prescribing’ Untested Coronavirus Treatments:

• ‘Panic Prescribing’ Untested Coronavirus Treatments: A Danger To Patients Today and Tomorrow – Health Affairs
• We shouldn’t rush to use an unproven malaria drug to treat the coronavirus – STAT
• See also: Twitter Thread on the Latest Study Testing Hydroxychloroquine, by Lucas Morin

 

4 – Consensus guidelines for managing the airway in patients with COVID‐19 – Anaesthesia

Related Guidelines:

• Guidance: COVID-19 Airway Management Principles – Intensive Care Society; The Faculty of Intensive Care Management; Association of Anaesthetists; and Royal College of Anaesthetists AND Summary: COVID-19 Airway Management Principles 
• Consensus statement: Safe Airway Society principles of airway management and tracheal intubation specific to the COVID-19 adult patient group – Medical Journal of Australia 

 

5 – Recommendations from the Peking Union Medical College Hospital for the management of acute myocardial infarction during the COVID-19 outbreak – European Heart Journal

Related: CSC Expert Consensus on Principles of Clinical Management of Patients with Severe Emergent Cardiovascular Diseases during the COVID-19 Epidemic – Circulation

 

6 – COVID-19 in Older Adults: Key Points for Emergency Department Providers – Journal of Geriatric Emergency Medicine

Commentary: Caring for seniors during COVID-19 pandemic – Regenstrief Institute

 

7 – Preliminary Estimates of the Prevalence of Selected Underlying Health Conditions Among Patients with Coronavirus Disease 2019 — United States, February 12–March 28, 2020 – CDC Morbidity and Mortality Weekly Report

Commentaries: More than 70% of Americans hospitalized with COVID-19 had at least 1 underlying health condition, the CDC says — here’s the breakdown – Business Insider AND People With Underlying Health Conditions Are At Risk Of More Severe COVID-19, Says New CDC Report – Forbes AND Who’s Sickest From COVID-19? These Conditions Tied To Increased Risk – NPR

 

8 – Characteristics of Ocular Findings of Patients With Coronavirus Disease 2019 (COVID-19) in Hubei Province, China – JAMA Ophthalmology

Invited Commentary: Humans, Viruses, and the Eye—An Early Report From the COVID-19 Front Line – JAMA Ophthalmology

See also: Perspectives on Coronavirus Disease 2019 Control Measures for Ophthalmology Clinics Based on a Singapore Center Experience – JAMA Ophthalmology

 

9 – Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic – JAMA Otolaryngology Head & Neck Surgery

Author Interview: Safety Recommendations for Evaluation and Surgery of the Head and Neck During the COVID-19 Pandemic

Related: Surgical Considerations for Tracheostomy During the COVID-19 Pandemic: Lessons Learned From the Severe Acute Respiratory Syndrome Outbreak – JAMA Otolaryngology Head & Neck Surgery

 

10 – Coronavirus Disease (COVID-19) Updates / 01 April 2020 Edition

01 April 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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Tue March 31 – 10 Stories of The Day!

31 Mar, 2020 | 05:04h | UTC

 

1 – CSC Expert Consensus on Principles of Clinical Management of Patients with Severe Emergent Cardiovascular Diseases during the COVID-19 Epidemic – Circulation

 

2 – Report 13: ­­Estimating the number of infections and the impact of non-pharmaceutical interventions on COVID-19 in 11 European countries – Imperial College London

See also: Summary

 

3 – Estimates of the severity of coronavirus disease 2019: a model-based analysis – The Lancet Infectious Diseases

Commentaries: Likelihood of survival of coronavirus disease 2019 – The Lancet Infectious Diseases AND New coronavirus study reveals increased risks from middle age – The Guardian

 

4 – Efficacy of hydroxychloroquine in patients with COVID-19: results of a randomized clinical trial – medRxiv

 

5 – COVID-19: Risks Related to the Use of Hydroxychloroquine

• Ventricular Arrhythmia Risk Due to Hydroxychloroquine-Azithromycin Treatment For COVID-19 – American College of Cardiology
• A Rush to Judgment? Rapid Reporting and Dissemination of Results and Its Consequences Regarding the Use of Hydroxychloroquine for COVID-19 – Annals of Internal Medicine

 

6 – Be it resolved, we are making high-stakes decisions about the COVID-19 pandemic without reliable data. – Munk Debates Podcast

Related Video: Perspectives on the Pandemic with Dr. John Ioannidis

Related Article: Editorial by John P.A. Ioannidis: COVID-19: The Harms of Exaggerated Information and Non‐evidence‐based Measures (free study and commentaries)

 

7 – The Mathematics of Predicting the Course of the Coronavirus – Wired

See also: Mathematics of life and death: How disease models shape national shutdowns and other pandemic policies – Science AND How to model a pandemic – The Conversation AND Coronavirus exposes the problems and pitfalls of modelling – The Guardian AND Systematic review and critical appraisal of prediction models for diagnosis and prognosis of COVID-19 infection – medRxiv

 

8 – SARS-CoV-2–Positive Sputum and Feces After Conversion of Pharyngeal Samples in Patients With COVID-19 – Annals of Internal Medicine

Commentary: COVID-19 found in sputum and feces samples after pharyngeal specimens no longer positive – American College of Physicians

 

9 – “Immunity Certificates” to Leave Lockdown Early?

• ‘Immunity passports’ could speed up return to work after Covid-19 – The Guardian
• How Covid-19 immunity testing can help people get back to work – Vox
• Germany will issue coronavirus antibody certificates to allow quarantined to re-enter society – The Telegraph
• Germany could issue thousands of people coronavirus ‘immunity certificates’ so they can leave the lockdown early – Business Insider

 

10 – Coronavirus Disease (COVID-19) Updates / 31 March 2020 Edition

31 March 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

 

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