TOP 10 Medical News Stories
Fri June 05 – 10 Stories of The Day!
5 Jun, 2020 | 05:09h | UTC
1 – Lancet, New England Journal Retract Covid-19 Studies, Including one That Raised Safety Concerns About Malaria Drugs
Science: Two elite medical journals retract coronavirus papers over data integrity questions
Editorial: Renin–angiotensin system inhibitors in the COVID-19 pandemic: consequences of antihypertensive drugs
Commentaries: Expert reaction to study looking at link between high blood pressure and risk of dying from COVID-19 – Science Media Centre AND Blood pressure drugs linked to lower COVID-19 mortality: study – Reuters
3 – COVID-19: 10 things I wished I’d known some months ago – Intensive Care Medicine
Related (just published): Serology assays to manage COVID-19 – Science
5 – Challenge Trials—Could Deliberate Coronavirus Exposure Hasten Vaccine Development? – JAMA
Related: Opinion: Ethical Guidelines for Deliberately Infecting Volunteers with COVID-19 to Speed Vaccine Development (other commentaries on the subject)
6 – Thinking of Risk in the Era of COVID-19 – JAMA
Related Article: Making Decisions in a COVID-19 World – JAMA
7 – COVID-19 vaccine development pipeline gears up – The Lancet
9 – COVID-19 Can Last for Several Months – The Atlantic
10 –COVID-19 Updates / 05 June 2020 Edition
05 June 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Thu June 04 – 10 Stories of The Day!
4 Jun, 2020 | 05:14h | UTC
Editorial: Hydroxychloroquine for the Prevention of Covid-19 — Searching for Evidence
Commentaries: Hydroxychloroquine does not prevent Covid-19 infection if exposed, study says – STAT AND The first high-quality study of malaria pill hydroxychloroquine just found it doesn’t help prevent coronavirus infections – Business Insider AND No Evidence Hydroxychloroquine Is Helpful In Preventing COVID-19, Study Finds – NPR
2 – Audio Interview: Diagnosis and Early Treatment of Covid-19 – New England Journal of Medicine
Editorial: A Randomized Trial of Convalescent Plasma for COVID-19—Potentially Hopeful Signals – JAMA
5 – Head to Head: Should governments continue lockdown to slow the spread of covid-19? – The BMJ
6 – COVID-19 diagnostics in context – Science Translational Medicine
Related: IDSA Guidelines on the Diagnosis of COVID-19 AND Interpreting Diagnostic Tests for SARS-CoV-2 – JAMA AND Interpreting a covid-19 test result – The BMJ
7 – Why coronavirus hits men harder: sex hormones offer clues – Science
8 – Will the pandemic permanently alter scientific publishing? – Nature
9 – How scientific conferences will survive the coronavirus shock – Nature
10 –COVID-19 Updates / 04 June 2020 Edition
04 June 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Wed June 03 – 10 Stories of The Day!
3 Jun, 2020 | 04:03h | UTC
1 – Video: Coronavirus Q&A with Anthony Fauci, MD – JAMA
2 – Coronavirus: what a second wave might look like – The Conversation
Commentary: Just Stop the Superspreading – The New York Times
Related: Why do some COVID-19 patients infect many others, whereas most don’t spread the virus at all? – Science AND ‘Superspreaders’ Could Actually Make Covid-19 Easier to Control – Bloomberg
4 – Studies Estimate Covid-19 Infection Risk in Health Care Workers
Editorial: Estimating Coronavirus Disease 2019 Infection Risk in Health Care Workers – JAMA Network Open
Commentary: Patterns of COVID-19 in Health Professionals Offers Clues for Disease Control – TCTMD
5 – Blood vessel attack could trigger coronavirus’ fatal ‘second phase’ – Science
7 – Basic Psychosocial Skills: A Guide for COVID-19 Responders – Inter-Agency Standing Committee
News Release: Basic Psychosocial Skills: A Guide for COVID-19 Responders – World Health Organization
See also: An Open Letter to Mehra et al and The Lancet (further commentaries on the subject)
Commentary: Top medical journals raise concerns about data in two studies related to Covid-19 – STAT
“we are issuing an Expression of Concern to alert readers to the fact that serious scientific questions have been brought to our attention. We will update this notice as soon as we have further information.”
See also: An open letter to Mehra et al and The New England Journal of Medicine – Zenodo
Commentary: Top medical journals raise concerns about data in two studies related to Covid-19 – STAT
“We have asked the authors to provide evidence that the data are reliable. In the interim and for the benefit of our readers, we are publishing this Expression of Concern about the reliability of their conclusions.”
10 –COVID-19 Updates / 03 June 2020 Edition
03 June 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Tue June 02 – 10 Stories of The Day!
2 Jun, 2020 | 05:15h | UTC
Commentaries: Most comprehensive study to date provides evidence on optimal physical distancing, face masks, and eye protection to prevent spread of COVID-19 – The Lancet AND Physical distancing, face masks, and eye protection for prevention of COVID-19 – The Lancet AND Medical Workers Should Use Respirator Masks, Not Surgical Masks – The New York Times AND Expert reaction to review of optimal physical distancing, face masks, and eye protection to prevent spread of COVID-19 – Science Media Centre AND Evidence supports physical distancing, masks, and eye protection to help prevent COVID-19 – McMaster University AND Social distancing and masks reduce risk of getting Covid-19, review finds – CNN
News Release: COVID-19 significantly impacts health services for noncommunicable diseases – World Health Organization
Commentary: COVID-19 Has ‘Severely’ Disrupted Chronic Disease Care, WHO Warns – Health Policy Watch
News Release: Maintaining essential health services: new operational guidance for the COVID-19 context
4 – Epidemiology of COVID-19 Among Children in China – Pediatrics
Commentaries: COVID-19 in Children: Initial Characterization of the Pediatric Disease – Pediatrics AND Coronavirus: is it safe for children to return to school? – The Conversation
6 – Airborne Spread of SARS-CoV-2 and a Potential Role for Air Disinfection – JAMA
7 – Anthony Fauci on Covid-19 reopenings, vaccines, and moving at ‘warp speed’ – STAT
8 – Universities will never be the same after the coronavirus crisis – Nature
9 – Remdesivir Shows Modest Improvement in Moderate COVID-19 Patients
- Gilead’s remdesivir shows modest improvement in moderate COVID-19 patients – Reuters
- Expert reaction to press release announcing results of stage 3 trial of Gilead’s antiviral remdesivir in moderate patients – Science Media Centre
- Gilead’s remdesivir shows some benefit in patients with moderate Covid-19, new data show – STAT
10 –COVID-19 Updates / 02 June 2020 Edition
02 June 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Mon June 01 – 10 Stories of The Day!
1 Jun, 2020 | 04:04h | UTC
Commentaries: Mitigating the risks of surgery during the COVID-19 pandemic – The Lancet AND COVID-19 patients who undergo surgery are at increased risk of postoperative death – University of Birmingham AND Clinicians must carefully balance risk of complications linked to SARS-CoV2 infection with risks of delaying surgery – The Lancet
2 – Cohort Studies: Clinical Impact of COVID-19 on Patients with Cancer
Study 1: Clinical impact of COVID-19 on patients with cancer (CCC19): a cohort study – The Lancet
Commentaries: Studies highlight COVID-19 impact on cancer patients – CIDRAP AND Cancer, coronavirus are a dangerous mix, new studies find – MedicalXpress AND Cancer, coronavirus are a dangerous mix, new studies find – Associated Press AND Cancer and COVID-19: what do we really know? – The Lancet
3 – An open letter to Mehra et al and The Lancet – Zenodo
See also: Disputed Hydroxychloroquine Study Brings Scrutiny to Surgisphere – The Scientist AND A Study Out of Thin Air – Medicine (Un)Censored
4 – Will Evidence-Based Medicine Survive COVID-19? – Boston Review
Related: A Review of Neurological Complications of COVID-19 – Cureus
6 – Ramipril in High Risk Patients with COVID-19 – Journal of the American College of Cardiology
10 –COVID-19 Updates / 01 June 2020 Edition
01 June 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Fri May 29 – 10 Stories of The Day!
29 May, 2020 | 03:36h | UTC
1 – Shielding from covid-19 should be stratified by risk – The BMJ
2 – COVID-19: in the footsteps of Ernest Shackleton – Thorax
Commentaries: New Paper Finds Startling Number Of Asymptomatic Covid-19 Carriers – Forbes AND Asymptomatic COVID-19 cases may be more common than suspected – NBC News AND Cruise ship study hints at many ‘silent’ COVID-19 infections – The BMJ
Commentaries: 40% of COVID-19 patients may be asymptomatic as disease progresses – UPI AND How Common Are Asymptomatic Cases of COVID-19? – U.S News
4 – Using Controlled Trials to Resolve Key Unknowns About Policy During the COVID-19 Pandemic – JAMA
6 – For Seniors, COVID-19 Sets Off A Pandemic Of Despair – Kaiser Health News
7 – Wastewater testing gains traction as a Covid-19 early warning system – STAT
Related: SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area – Water Research AND New Research Examines Wastewater to Detect Community Spread of Covid-19
Related: Challenge trials can speed development of a Covid-19 vaccine. Planning for them needs to start now – STAT AND AstraZeneca says it may consider exposing vaccine trial participants to virus – Reuters
9 – Ethical guidelines for COVID-19 tracing apps – Nature
10 –COVID-19 Updates / 29 May 2020 Edition
29 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Thu May 28 – 10 Stories of The Day!
28 May, 2020 | 10:03h | UTC
1 – Clinical management of COVID-19 – World Health Organization
2 – Remdesivir for 5 or 10 Days in Patients with Severe Covid-19 – New England Journal of Medicine
Related: Face coverings for the lay public: an alternative view – CEBM Oxford AND Cloth Masks May Prevent Transmission of COVID-19: An Evidence-Based, Risk-Based Approach – Annals of Internal Medicine
5 – Reducing transmission of SARS-CoV-2 – Science
6 – The unexpected side effect of Covid-19 – CNN
“After Covid-19, if we dare imagine the day, it will be important to ask who was harmed by delayed and forgone medical care. But the severe financial strains on individuals and public budgets make it just as essential to ask who benefited from avoiding interventions with no salutatory effect.”
Commentary: New CDC Guidelines: Test All Newborns With Covid-19 Positive Moms – Forbes
10 –COVID-19 Updates / 28 May 2020 Edition
28 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Wed May 27 – 10 Stories of The Day!
27 May, 2020 | 02:50h | UTC
2 – WHO Manifesto for a healthy recovery from COVID-19 – World Health Organization
“I think or know I had COVID-19, and I had symptoms”.
You can be with others after:
- 3 days with no fever AND
- Symptoms improved AND
- 10 days since symptoms first appeared”
Related Guidelines: NIH Coronavirus Disease 2019 (COVID-19) Treatment Guidelines – National Institutes of Health AND Infectious Diseases Society of America Guidelines on the Treatment and Management of Patients with COVID-19 Infection
“Apart from supportive care, there are no current effective therapeutics for COVID-19”
7 – The Totality of the Evidence – Boston Review
See other interesting perspectives from the Boston Review: Models v. Evidence AND Good Science Is Good Science
“Given what we know now, it is reasonable to consider alternatives to population-wide lockdown, even as we focus on protecting those most at risk and support health care systems to care for patients who are sick.”
10 –COVID-19 Updates / 27 May 2020 Edition
27 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Tue May 26 – 10 Stories of The Day!
26 May, 2020 | 10:08h | UTC
1 – COVID-19 and Cardiovascular Disease – Circulation
Related Guidelines: COVID-19 rapid guideline: acute myocardial injury – National Institute for Health and Care Excellence AND ESC Guidance for the Diagnosis and Management of CV Disease during the COVID-19 Pandemic – European Society of Cardiology AND Management of Acute Myocardial Infarction During the COVID-19 Pandemic – Journal of the American Academy of Cardiology
3 – Placental Pathology in COVID-19 – American Journal of Clinical Pathology
Commentaries: Placentas from COVID-19-positive pregnant women show injury – Northwestern University AND Expert reaction to study looking at placentas from COVID19-positive pregnant women – Science Media Centre AND Covid-19 appears to attack placenta during pregnancy, study says – CNN AND Placenta Injury Observed in Pregnant Women Who Test Positive For Coronavirus – Forbes
Related Perspective from the Author: In Defense of Evidence-Based Medicine for the Treatment of COVID-19 ARDS – Annals of the American Thoracic Society
5 – Report: Smart testing for COVID-19 virus and antibodies – CIDRAP
News Release: In new report, CIDRAP at the University of Minnesota proposes smart and strategic approach to COVID-19 testing
See also: Reports 1 and 2
6 – Perspective: In Pandemic, Many Seeing Upsides to Telemedicine
Part I: In pandemic, many seeing upsides to telemedicine – CIDRAP
Part II: COVID-19 reveals telehealth barriers, solutions – CIDRAP
7 – On coughing and airborne droplet transmission to humans – Physics of Fluids
Commentaries: Six feet not far enough to stop virus transmission in light winds – American Institute of Physics AND Expert reaction to paper studying mechanisms of coughing and airborne transmission of viruses – Science Media Centre AND Why 6 feet may not be enough social distance to avoid COVID-19 – Science News
8 – Here’s what needs to happen before we can all get vaccinated for COVID-19 – CBC
10 –COVID-19 Updates / 26 May 2020 Edition
26 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Mon May 25 – 10 Stories of The Day!
25 May, 2020 | 02:08h | UTC
1 – Remdesivir for the Treatment of Covid-19 — Preliminary Report – New England Journal of Medicine
Commentaries: Preliminary report on NIAID trial of remdesivir – PulmCrit AND Peer-reviewed data shows remdesivir for COVID-19 improves time to recovery – National Institutes of Health AND Covid-19 study details benefits of treatment with remdesivir, and also its limitations – STAT
Commentaries: Chloroquine or hydroxychloroquine for COVID-19: why might they be hazardous? – The Lancet AND What a big new study on malaria drugs as Covid-19 treatments tells us — and what it doesn’t – STAT AND Hydroxychloroquine May Cause More Harm Than Benefit To COVID-19 Patients, Says New Lancet Study – Health Policy Watch
3 – Why countries should stop using anti-malarial drugs for COVID-19 – The Conversation
Commentaries: First human trial of COVID-19 vaccine finds it is safe and induces rapid immune response – The Lancet AND Early Study Of Covid-19 Vaccine Developed In China Sees Mixed Results – Forbes AND Coronavirus Vaccine Shows Promising Early Results in China – The New York Times AND A Chinese biotech just published the first human data for its coronavirus vaccine candidate, supporting further trials – Business Insider AND Experts skeptical after researchers report positive vaccine results – CNN AND Two COVID-19 Vaccine Candidates Induce Immune Response In Healthy Volunteers – Health Policy Watch
5 – The world needs Covid-19 vaccines. It may also be overestimating their power – STAT
6 – SARS-CoV2 vaccines: Slow is fast – Science
Commentaries: Children appear half as likely to catch COVID-19 as adults – London School of Hygiene & Tropical Medicine AND Expert reaction to systematic review preprint looking at susceptibility to SARS-CoV-2 infection in children and adolescents compared with adults – Science Media Centre
Commentaries: Expert reaction to study on PCR testing results from 60 people after clinical recovery from COVID-19 – Science Media Centre AND 16% of recovered patients test positive for COVID-19 weeks after discharge: study – UPI
Related: New Research Examines Wastewater to Detect Community Spread of Covid-19
10 –COVID-19 Updates / 25 May 2020 Edition
25 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Fri May 22 – 10 Stories of The Day!
22 May, 2020 | 05:01h | UTC
Commentary: Lungs of deceased COVID-19 patients show distinctive features – Brigham and Women’s Hospital
Related: Postmortem Examination of Patients With COVID-19 – JAMA AND Pulmonary Arterial Thrombosis in COVID-19 With Fatal Outcome: Results From a Prospective, Single-Center, Clinicopathologic Case Series – Annals of Internal Medicine AND Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19 – Journal of Thrombosis and Haemostasis
3 – SARS2-CoV-2 and Stroke in a New York Healthcare System – Stroke
Commentary: COVID-19 patients may have lower stroke rates than previously suggested – NYU Grossman School of Medicine
4 – Ten reasons why immunity passports are a bad idea – Nature
Related: Ethical and Legal Challenges of COVID-19 Immunity Certificates (articles and commentaries on the subject) AND Privileges and Immunity Certification During the COVID-19 Pandemic – JAMA AND The Ethics of COVID-19 Immunity-Based Licenses (“Immunity Passports”) – JAMA
5 – How coronavirus lockdowns stopped flu in its tracks – Nature
“Reported rates of influenza and other infections have fallen sharply, but some communicable diseases may see a rise.”
6 – 15 drugs being tested to treat COVID-19 and how they would work – Nature
7 – Which interventions work best in a pandemic? – Science
8 – Ethics of controlled human infection to address COVID-19 – Science
9 – Open access: how COVID-19 will change the way research findings are shared – Wellcome
Related: Plan S: Making Full and Immediate Open Access a Reality AND UC Terminates Subscriptions with World’s Largest Scientific Publisher in Push for Open Access (several resources on the subject) AND PLOS and the University of California announce open access publishing agreement – PLOS Blogs AND The war to free science – Vox (free) AND WHO Joins Coalition for Free Digital Access to Health Research
10 –COVID-19 Updates / 22 May 2020 Edition
22 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Thu May 21 – 10 Stories of The Day!
21 May, 2020 | 09:29h | UTC
1 – SARS-CoV-2 infection protects against rechallenge in rhesus macaques – Science
Related Study: DNA vaccine protection against SARS-CoV-2 in rhesus macaques – Science
Commentaries: Infection With SARS-CoV-2 Protects Against Re-infection – At Least in Rhesus Macaques – Technology Networks AND Prototype Vaccine Protects Monkeys From Coronavirus – The New York Times
2 – Audio Interview: Capitalizing on Immune Responses to Covid-19 – New England Journal of Medicine
3 – Olfactory Dysfunction in COVID-19: Diagnosis and Management – JAMA
Related: Loss of smell and taste as symptoms of COVID-19: what does the evidence say? – CEBM Oxford
Related: Study Commentary: Before/after Study of Short-Course Steroid in COVID-19
6 – A Critical Look at A Preprint Inferring the Covid-19 Infection Fatality Rate – by Hilda Bastian
Original Preprint: The infection fatality rate of COVID-19 inferred from seroprevalence data – medRxiv
7 – COVID-19 in Children: Clinical Approach and Management – The Indian Journal of Pediatrics
Related Systematic Reviews: SARS-CoV-2 Infection in Children and Adolescents (study and commentaries) AND SARS-CoV-2 (COVID-19): What do we know about children? A systematic review – Clinical Infectious Diseases
Commentary: Outcomes of Patients Hospitalized for COVID-19 and Cardiac Disease – American College of Cardiology
Related: Association of Cardiovascular Disease With Coronavirus Disease 2019 (COVID-19) Severity: A Meta-Analysis – Current Problems in Cardiology AND Cardiology After COVID-19: Physicians Predict Lasting Change – TCTMD
See also: COVID-19: Updates for Cardiologists
10 –COVID-19 Updates / 21 May 2020 Edition
21 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Wed May 20 – 10 Stories of The Day!
20 May, 2020 | 10:03h | UTC
1 – Editorial: Lack of efficacy of hydroxychloroquine in covid-19 – The BMJ
Original Research: Hydroxychloroquine in patients with mainly mild to moderate coronavirus disease 2019: open label, randomised controlled trial – The BMJ
Related Meta-analysis (preprint): Hydroxychloroquine in COVID-19: A systematic review and meta-analysis – medRxiv
2 – Covid Patients Testing Positive After Recovery Aren’t Infectious, Study Shows – Bloomberg
Original Article: Saliva—Friend and Foe in the COVID-19 Outbreak – Diagnostics
4 – Reducing the Risk of Diagnostic Error in the COVID-19 Era – Journal of Hospital Medicine
Commentaries: Critically ill patients with COVID-19 in New York City – The Lancet AND Nearly 40% of critically ill COVID-19 patients in New York City died, study finds – UPI
6 – Personal Protective Equipment and Covid-19 – New England Journal of Medicine
Related Study: Reduced Rate of Hospital Admissions for ACS during Covid-19 Outbreak in Northern Italy – New England Journal of Medicine
8 – Serology for SARS-CoV-2: Apprehensions, opportunities, and the path forward – Science Immunology
10 –COVID-19 Updates / 20 May 2020 Edition
20 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Tue May 19 – 10 Stories of The Day!
19 May, 2020 | 04:42h | UTC
1 – Management of acute kidney injury in patients with COVID-19 – The Lancet Respiratory Medicine
Related: Acute Kidney Injury In Patients Hospitalized With Covid-19 – Kidney International
Related Case Report: Cardiac dysfunction and thrombocytopenia-associated multiple organ failure inflammation phenotype in a severe paediatric case of COVID-19 – The Lancet Child & Adolescent Health
4 – Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody – Nature
Commentary: Cross-neutralization of SARS and COVID-19 coronaviruses by a monoclonal antibody – News Medical
“the prevalence of antibodies to SARS-CoV-2 was 4.65%. The estimate implies that approximately 367 000 adults had SARS-CoV-2 antibodies, which is substantially greater than the 8430 cumulative number of confirmed infections in the county on April 10”
Related Viewpoint: Planning for a COVID-19 Vaccination Program – JAMA
8 – Early data show Moderna Covid-19 vaccine generates immune response – STAT
See also: Moderna Coronavirus Vaccine Trial Shows Promising Early Results – The New York Times AND Expert reaction to Moderna announcement about their phase 1 trial data on their mRNA vaccine (mRNA-1273) candidate against COVID-19 – Science Media Centre
Commentaries: More evidence US childhood vaccinations are dropping amid coronavirus pandemic – CNN AND Michigan reports a sharp drop in child vaccinations after the CDC warned missed shots could lead to a measles resurgence across the US – Business Insider
10 –COVID-19 Updates / 19 May 2020 Edition
19 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Mon May 18 – 10 Stories of The Day!
18 May, 2020 | 02:22h | UTC
News Release: Multisystem inflammatory syndrome in children and adolescents temporally related to COVID-19
Related: Covid-19: Cases of inflammatory syndrome in children surge after urgent alert – The BMJ AND Description of an Outbreak of Severe Kawasaki-like Disease at the Italian Epicenter of the SARS-CoV-2 Epidemic
2 – Policy Brief: COVID-19 and the Need for Action on Mental Health – World Health Organization
News Release: Substantial investment needed to avert mental health crisis – World Health Organization
Commentary: “Mental health services are an essential part of all government responses to COVID-19” – United Nations
3 – New NICE Covid-19 Rapid Guidelines: Chronic Kidney Disease & Interstitial Lung Disease
COVID-19 rapid guideline: chronic kidney disease – National Institute for Health and Care Excellence
See also: Complete Collection of Covid-19 Rapid Guidelines
Commentary: Further evidence does not support hydroxychloroquine for patients with COVID-19 – BMJ
5 – Severe Covid-19 – New England Journal of Medicine
Commentary: Walking the line between benefit and harm from tracheostomy in COVID-19 – The Lancet Respiratory Medicine
10 –COVID-19 Updates / 18 May 2020 Edition
18 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Fri May 15 – 10 Stories of The Day!
15 May, 2020 | 03:55h | UTC
Commentaries: Kawasaki-like disease: emerging complication during the COVID-19 pandemic – The Lancet AND Kawasaki-like COVID-19 complication found in Italian kids – CIDRAP AND What we know about the new Covid-19-linked illness in children – Vox AND Coronavirus: Children affected by rare Kawasaki-like disease – BBC
Related: Case Series: Hyperinflammatory Shock in Children During COVID-19 Pandemic
2 – Early Safety Indicators of COVID-19 Convalescent Plasma in 5,000 Patients – medRxiv
Commentary: Convalescent plasma is safe to treat COVID-19: nationwide study – NBC News
Related: Face Masks Against COVID-19: An Evidence Review – Preprints AND Face Masks for the Public During the Covid-19 Crisis
Commentaries: Expert reaction to study looking at speech-generated droplets and COVID-19 transmission – Science Media Centre AND Loud Talking Can Spread More than 1,000 Coronavirus Particles in the Air for 14 Minutes: Study – The Science Times AND Simply talking in confined spaces may be enough to spread the coronavirus, researchers say – USA Today AND Loud talking could leave coronavirus in the air for up to 14 minutes – MIT Technology Review
Related: The Covid-19 Crisis too Few are Talking About: Health Care Workers’ Mental Health (commentaries on the subject)
8 – Audio Interview: Finding Reliable Information about Covid-19 – New England Journal of Medicine
10 –COVID-19 Updates / 15 May 2020 Edition
15 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Thu May 14 – 10 Stories of The Day!
14 May, 2020 | 10:18h | UTC
Related: Gastrointestinal, Hepatobiliary, and Pancreatic Manifestations of COVID-19 (review and guideline) AND Abdominal Imaging Findings in COVID-19: Preliminary Observations – Radiology
2 – SARS-CoV-2 Rates in BCG-Vaccinated and Unvaccinated Young Adults – JAMA
Related: BCG Against Coronavirus: Less Hype And More Evidence, Please – Forbes AND Does BCG vaccination protect against acute respiratory infections and COVID-19? A rapid review of current evidence – CEBM University of Oxford AND Bacille Calmette-Guérin (BCG) vaccination and COVID-19 – World Health Organization
3 – Before/after study of short-course steroid in COVID-19 – PulmCrit
Original Study (Preprint): Early Short Course Corticosteroids in Hospitalized Patients with COVID-19 – medRxiv
Commentaries: Scientists develop online calculator to predict individual’s risk of dying from Covid-19 – The Independent AND Expert reaction to study estimating excess deaths over one year directly or indirectly related to COVID-19 based on underlying health conditions and age of UK population, and making comments on the effect of easing the lockdown – Science Media Centre
See calculator: OurRisk.CoV
Commentaries: As COVID-19 devastates already fragile health systems, over 6,000 additional children under five could die a day, without urgent action – UNICEF AND Unicef: 6,000 children could die every day due to impact of coronavirus – The Guardian
6 – Virtual care: new models of caring for our patients and workforce – The Lancet Digital Health
8 – Coronavirus Test Shortages Trigger a New Strategy: Group Screening – Scientific American
Related: Pooling of Samples for Testing for SARS-CoV-2 in Asymptomatic People (studies and commentaries) AND Sample Pooling as a Strategy to Detect Community Transmission of SARS-CoV-2 – JAMA Network
Commentary: Endovascular Therapy for Acute Ischemic Stroke During COVID-19 Pandemic – American College of Cardiology
10 – Coronavirus Disease (COVID-19) Updates / 14 May 2020 Edition
14 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Wed May 13 – 10 Stories of The Day!
13 May, 2020 | 02:20h | UTC
1 – Practice Pointer: Interpreting a covid-19 test result – The BMJ
Related: Interpreting Diagnostic Tests for SARS-CoV-2 – JAMA
2 – Waste in covid-19 research – The BMJ
Related Landmark Paper from the Author: Avoidable waste in the production and reporting of research evidence – The Lancet (free registration required)
See also: Calculation Tool For Predicting Critical-ill COVID-19 At Admission
Related Preprint Study (just published): Development and validation of the COVID-19 severity index (CSI): a prognostic tool for early respiratory decompensation – medRxiv AND Calculation Tool: https://covidseverityindex.org/
4 – Virus Wars: Return of Lopinavir/Ritonavir (along with ribavirin and interferon) – PulmCrit
Original Article: Triple Therapy Antiviral Combination Seems Promising for COVID-19 in Open-label, Randomized, Phase 2 Trial (study and commentaries)
5 – New Zealand eliminates COVID-19 – The Lancet
See also: How New Zealand ‘eliminated’ Covid-19 after weeks of lockdown – CNN AND New Zealand has ‘effectively eliminated’ coronavirus. Here’s what they did right. – National Geographic AND Why New Zealand’s Coronavirus Elimination Strategy Is Unlikely to Work in Most Other Places – TIME
Original Article: A novel bat coronavirus closely related to SARS-CoV-2 contains natural insertions at the S1/S2 cleavage site of the spike protein – Current Biology
9 – A Pandemic Benefit: The Expansion of Telemedicine – The New York Times
Related: COVID-19: Rapidly Converting to “Virtual Practices” (several commentaries on the subject) AND A digital embrace to blunt the curve of COVID19 pandemic – npj Digital Medicine
10 – Coronavirus Disease (COVID-19) Updates / 13 May 2020 Edition
13 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Tue May 12 – 10 Stories of The Day!
12 May, 2020 | 03:41h | UTC
Commentaries: A study of 48 children in intensive care with the coronavirus found 18 needed ventilators. Most had underlying conditions – Business Insider AND Study Offers Details of U.S. Children Severely Sickened by Coronavirus – The New York Times
Original Preprints: Potential effects of disruption to HIV programmes in sub-Saharan Africa caused by COVID-19: results from multiple mathematical models AND Estimation of the potential effects of disruption to HIV programs in sub-Saharan Africa caused by COVID-19: results from multiple models APPENDIX
5 – AIDS, TB And Malaria Set To Get Deadlier Due To Coronavirus – Forbes
Related: AIDS, TB And Malaria: Coronavirus Threatens The Endgame – Forbes AND The Potential Impact of the COVID-19 Epidemic on HIV, TB and Malaria in Low- and Middle-Income Countries – Imperial College London AND The potential impact of health service disruptions on the burden of malaria: a modelling analysis for countries in sub-Saharan Africa – World Health Organization AND The Potential Impact Of The Covid-19 Response On Tuberculosis In High-Burden Countries: A Modelling Analysis
6 – Abdominal Imaging Findings in COVID-19: Preliminary Observations – Radiology
News Release: Imaging reveals bowel abnormalities in patients with COVID-19 – Radiological Society of North America
7 – Real-time tracking of self-reported symptoms to predict potential COVID-19 – Nature Medicine
Commentaries: New AI diagnostic can predict COVID-19 without testing – King’s College London AND Expert reaction to study looking at possibility of using real-time tracking of self-reported symptoms to predict potential COVID-19 without testing – Science Media Centre AND Coronavirus: research reveals way to predict infection – without a test – The Conversation AND Loss of smell and taste may actually be one of the clearest signs of COVID-19 – Science News
8 – Ethics and governance for digital disease surveillance – Science
9 – Richard Lehman’s Covid-19 Reviews, 11 May 2020 – The BMJ Opinion
In this weekly round-up, Richard Lehman looks at a personal selection of articles of relevance to clinicians dealing with covid-19
10 – Coronavirus Disease (COVID-19) Updates / 12 May 2020 Edition
12 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Mon May 11 – 10 Stories of The Day!
11 May, 2020 | 00:44h | UTC
Commentaries: Interferon beta-1b for COVID-19 – The Lancet AND New triple antiviral drug combination shows early promise for treating COVID-19 in phase 2 randomized trial – The Lancet AND A Drug Cocktail Hastens Recovery in Some Coronavirus Patients – The New York Times AND Triple drug therapy helps coronavirus patients recover more quickly, study finds – CNN AND Triple antiviral drug shows early promise in COVID-19 trial – Reuters AND Expert reaction to a study about a phase 2 trial of a triple antiviral drug combination treatment for COVID-19 – Science Media Centre
2 – Do Not Stay at Home: We Are Ready for You – NEJM Catalyst
“We must never lose sight of all the other patients who need our care today. Patients with any symptom indicating an emergency or severe disease must NOT stay at home.”
3 – Surfing the Waves of the COVID-19 Pandemic As A Cardiovascular Clinician – Circulation (PDF)
Commentary: Stroke evaluations drop by nearly 40% during COVID-19 pandemic – Washington University School of Medicine
Commentaries: Expert reaction to study looking at use of arthritis drug anakinra in hospitalised patients with severe COVID-19 – Science Media Centre AND Small study of patients with severe COVID-19 treated with the arthritis drug anakinra finds clinical improvements – The Lancet
Commentaries: Guidance for Treating Stroke Patients During COVD-19 Crisis Developed – Boston University School of Medicine AND Mechanical Thrombectomy and Emergency Preparedness Guidance in COVID-19 Era – American College of Cardiology
News Release: Canadian study finds temperature, latitude not associated with COVID-19 spread – Canadian Medical Association Journal
8 – The emerging long-term complications of Covid-19, explained – Vox
Related: Coronavirus: Sickest patients face long recovery – BBC AND Surviving Covid-19 May Not Feel Like Recovery for Some – New England Journal of Medicine
9 – COVID-19 Research in Brief: 2 May to 8 May, 2020 – Nature Medicine
10 – Coronavirus Disease (COVID-19) Updates / 11 May 2020 Edition
11 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Fri May 08 – 10 Stories of The Day!
8 May, 2020 | 10:44h | UTC
Editorial: The Urgency of Care during the Covid-19 Pandemic — Learning as We Go
2 – Audio Interview: Studying Potential Covid-19 Therapies – New England Journal of Medicine
5 – Modeling shield immunity to reduce COVID-19 epidemic spread – Nature Medicine
Commentaries: Immunity of Recovered COVID-19 Patients Could Cut Risk of Expanding Economic Activity – Georgia Institute of Technology AND After Recovery From the Coronavirus, Most People Carry Antibodies – New York Times
Press release: Risk factors for COVID-19 death revealed in world’s largest analysis of patient records to date
8 – COVID-19 in Older People: A Rapid Clinical Review – Age and Ageing
News Release: Treatment for Diverticulitis – updated ASCRS Guidelines published in Diseases of the Colon & Rectum
10 – Coronavirus Disease (COVID-19) Updates / 08 May 2020 Edition
08 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Thu May 07 – 10 Stories of The Day!
7 May, 2020 | 09:36h | UTC
1 – Infectious Diseases Society of America Guidelines on the Diagnosis of COVID-19
Related IDSA Coronavirus Guidelines: Part 1: Treatment and Management AND Part 2: Infection Prevention
4 – Interpreting Diagnostic Tests for SARS-CoV-2 – JAMA
News Release: Position statement addresses difficult issue: allocating scare resources in COVID-19 era – American Geriatrics Society
“Age should never be used as a means for categorically excluding someone from what is ordinarily the standard of care, nor should age “cut-offs” be used in allocation strategies.”
6 – Hyperinflammatory shock in children during COVID-19 pandemic – The Lancet
Commentaries: Researchers report “unprecedented cluster” of inflammatory problems in children amid pandemic – CNN AND Expert reaction to report on 8 children with hyperinflammatory shock during the COVID-19 pandemic – Science Media Centre AND Mysterious inflammatory syndrome in children potentially linked to COVID-19 reported in Montreal – National Post AND A New Coronavirus Threat to Children – The New York Times AND What to Know About Kawasaki Disease, the Pediatric Inflammatory Condition Possibly Linked to COVID-19 – TIME AND Kawasaki Disease—The Latest Weird Illness From Coronavirus – Forbes
Related Study: Pathological evidence of pulmonary thrombotic phenomena in severe COVID-19 – Journal of Thrombosis and Haemostasis
Commentaries: Giving blood thinners to severely ill Covid-19 patients is gaining ground – STAT AND Blood thinners may improve survival among hospitalized COVID-19 patients – Mount Sinai Hospital AND Anticoagulation Associated With Improved Outcomes in Hospitalized COVID-19 Patients – American College of Cardiology AND Expert reaction to study looking at blood thinners in hospitalised patients with COVID-19 – Science Media Centre
9 – Acute limb ischaemia in two young, non-atherosclerotic patients with COVID-19 – The Lancet
10 – Coronavirus Disease (COVID-19) Updates / 07 May 2020 Edition
07 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Wed May 06 – 10 Stories of The Day!
6 May, 2020 | 04:02h | UTC
1 – COVID-19: A physician practice guide to reopening – American Medical Association
News Release: AMA launches physician guide for reopening medical practices
News Release: New COVID-19 guidance for gastroenterologists
3 – Can We Discuss Flatten-the-Curve in COVID19? My Eight Assertions – Dr. John M
4 – Awake Proning for COVID-19 – PulmCrit
5 – Mutant coronavirus story upsets scientists about preprint journalism – HealthNewsReview
Original Story: Scientists say a now-dominant strain of the coronavirus appears to be more contagious than original – Los Angeles Times
Original Preprint Study: Spike mutation pipeline reveals the emergence of a more transmissible form of SARS-CoV-2 – bioRxiv
6 – Should schools reopen? Kids’ role in pandemic still a mystery – Science
Related: Did Closing Schools Actually Help? – The New York Times AND New Studies Add to Evidence that Children May Transmit the Coronavirus – The New York Times AND When Should Schools Reopen? – Center for Global Development AND Systematic Review: School Closure During Coronavirus Outbreaks AND Children are not COVID-19 super spreaders: time to go back to school – Archives of Disease in Childhood
See also: Recovered patients who tested positive for COVID-19 likely not reinfected – Live Science AND South Korea says recovered coronavirus patients who tested positive again did not relapse: Tests picked up ‘dead virus fragments’ – Business Insider
Editorial: Covid-19: adverse mental health outcomes for healthcare workers
10 – Coronavirus Disease (COVID-19) Updates / 06 May 2020 Edition
06 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Tue May 05 – 10 Stories of The Day!
5 May, 2020 | 05:07h | UTC
1 – COVID-19: Out-of-control science and bypassing science-based medicine – Science Based Medicine
Related: Covid-19 — A Reminder to Reason – New England Journal of Medicine AND Pandemic Science Out of Control – Issues in Science and Technology AND Science Has an Ugly, Complicated Dark Side. And the Coronavirus Is Bringing It Out – Mother Jones AND Against pandemic research exceptionalism – Science AND In Defense of Evidence-Based Medicine for the Treatment of COVID-19 ARDS – Annals of the American Thoracic Society
2 – Randomized Clinical Trials and COVID-19: Managing Expectations – JAMA
3 – Obesity could shift severe COVID-19 disease to younger ages – The Lancet
5 – Cancer Patient Management During the Covid-19 Pandemic – European Society of Medical Oncology
Related: NCCN Guidance: How to Keep our Oncology Patients and Healthcare Workers Safe AND ASCO Recommendations for the Oncology Community During the COVID19 Pandemic AND COVID-19 rapid guideline: delivery of systemic anticancer treatments – NICE AND COVID-19 rapid guideline: delivery of radiotherapy – NICE AND Caring for patients with cancer in the COVID-19 era – Nature Medicine
6 – Critical Conversations: Say This, Not That – CHEST
Related: Covid-19 ‘immunity certificates’: practical and ethical conundrums – STAT AND The Dangerous History of Immunoprivilege – The New York Times AND “COVID-19 ‘Immunity Passports’ and Dystopian Segregation: A Few Concerns” – Bioethics.net
10 – Coronavirus Disease (COVID-19) Updates / 05 May 2020 Edition
05 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)
Mon May 04 – 10 Stories of The Day!
3 May, 2020 | 22:51h | UTC
1 – New NICE Coronavirus Rapid Guidelines
- COVID-19 rapid guideline: antibiotics for pneumonia in adults in hospital – National Institute for Health and Care Excellence
- COVID-19 rapid guideline: gastrointestinal and liver conditions treated with drugs affecting the immune response – National Institute for Health and Care Excellence
- COVID-19 rapid guideline: children and young people who are immunocompromised – National Institute for Health and Care Excellence
See Previous NICE Coronavirus Guidelines: Rapid guidelines and evidence summaries – National Institute for Health and Care Excellence
Related: New Scoring System to Prioritize Medically Necessary Operations (report and commentary)
News Release: COVID-19: The CIDRAP Viewpoint
4 – New Observational Studies Confirm the Safety of Renin–Angiotensin–Aldosterone System Blockers in Patients with Covid-19
Study 3: Cardiovascular Disease, Drug Therapy, and Mortality in Covid-19 – New England Journal of Medicine
Commentary: Blood Pressure Drugs Don’t Increase Coronavirus Risk, Studies Find – The New York Times
See also: Observational Study: Renin-Angiotensin System Inhibitors are Not Associated with Severity or Mortality in Hospitalized Patients with Coronavirus Disease (2 other studies on the subject)
Related Systematic Review: SARS-CoV-2 Infection in Children and Adolescents (study and commentaries)
Commentary: PulmCrit – Is COVID-19 ARDS, pseudoARDS, L, or H? Physiology data from Boston – PulmCrit
7 – Public Health Measures and the Reproduction Number of SARS-CoV-2 – JAMA
Related Editorial: Public Health Interventions for COVID-19: Emerging Evidence and Implications for an Evolving Public Health Crisis – JAMA
8 – COVID-19 – exploring the implications of long-term condition type and extent of multimorbidity on years of life lost: a modelling study – Wellcome Open Research (via @EricTopol see Tweet – Thread)
Commentary: Coronavirus deaths ‘result in more than 10 years of life lost per person’ – Express & Star
Commentary: Expert reaction to study looking at COVID-19, ischaemic stroke and blood clots – Science media Centre
Related: Large-Vessel Stroke as a Presenting Feature of Covid-19 in the Young – New England Journal of Medicine AND Coronavirus’s new mystery: It’s causing strokes in healthy people – Vox AND What’s Behind the Sharp Increase in Large-Vessel Stroke Risk in Young, Healthy COVID-19 Patients? – Neurology Today
10 – Coronavirus Disease (COVID-19) Updates / 04 May 2020 Edition
04 May 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)