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TOP 10 Medical News Stories

Mon, September 10 – 10 Stories of The Day!

10 Sep, 2018 | 00:10h | UTC

 

1 – 2018 European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism – European Thyroid Journal (free) (via @CristobMorales and @Abraham_RMI)

 

2 – Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Pediatric Critical Care Medicine (free)

 

3 – Viewpoint: Aligning Patient and Physician Incentives – JAMA (free for a limited period)

 

4 – Top Cancer Researcher Fails to Disclose Corporate Financial Ties in Major Research Journals – ProPublica (free)

 

5 – Financial Conflicts of Interest Among Oncologist Authors of Reports of Clinical Drug Trials – JAMA Oncology (link to abstract – $ for full-text)

Commentaries: Financial disclosure lacking in publication of clinical trials – eCancer News (free) AND Oncologist-Authors Often Do Not Fully Disclose Financial Relationships with Pharmaceutical Companies – MedicalResearch.com (free) AND One-third of oncologist authors fail to disclosure industry payments – Healio News (free registration required)

 

6 – Palliative care in intensive care units: why, where, what, who, when, how – BMC Anesthesiology (free)

 

7 – Idiopathic Pulmonary Fibrosis (IPF): An Overview – Journal of Clinical Medicine (free)

 

8 – Perspective: The Moral Dilemma of Learning Medicine from the Poor – The Doctors Weight In (free) (via @kennylinafp)

I learned good skills because I was allowed to practice on people who had no other option.”

 

9 – Peer reviewers unmasked: largest global survey reveals trends – Nature News (free)

Original Report: 2018 Global State of Peer Review (free)

 

10 – Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction – JAMA Network Open (free) (via @LuisCLCorreia)

“There is substantial variability in LVEF assessment between modalities, which should be considered in trial design and clinical management.”

 


Fri, September 7 – 10 Stories of The Day!

7 Sep, 2018 | 02:15h | UTC

 

1 – Guideline: Pancreatitis – National Institute for Health and Care Excellence (free)

 

2 – Clinically Localized Prostate Cancer: ASCO Clinical Practice Guideline Endorsement of an American Urological Association/American Society for Radiation Oncology/Society of Urologic Oncology Guideline – Journal of Clinical Oncology (free)

 

3 – Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study – The BMJ (free)

Editorial: Primary prevention with statins for older adults (free)

Commentaries: Expert reaction to study on use of statins in older people – Science Media Centre (free) AND Widespread use of statins in healthy older people to prevent heart disease not recommended in new study – BMJ, via ScienceDaily (free)

New research does not support widespread use of statins in healthy older people to prevent heart disease and stroke. Results found that any protective effect was limited to those with type 2 diabetes aged between 75 and 84” (via @bmj_latest see Tweet)

 

4 – Commission: High-quality health systems in the Sustainable Development Goals era: time for a revolution – The Lancet Global Health (free articles)

Related Article: Mortality due to low-quality health systems in the universal health coverage era: a systematic analysis of amenable deaths in 137 countries – The Lancet (free)

Editorial: Putting quality and people at the centre of health systems – The Lancet (free)

Commentaries: Political and technical barriers to improving quality of health care – The Lancet (free) AND What Kills 5 Million People A Year? It’s Not Just Disease – NPR (free)

Related Report: Crossing the Global Quality Chasm: Improving Health Care Worldwide (free report and commentaries)

 

5 – The 2018 Surviving Sepsis Campaign’s Treatment Bundle: When Guidelines Outpace the Evidence Supporting Their Use – Annals of Emergency Medicine (free) (via @EMNerd)

Related Opinions: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free) AND The Surviving Sepsis Campaign: A Rush to Judgment – NEJM Journal Watch (free)

Original Guideline: The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)

 

6 – Tuberculosis: the curable disease on the rise, and how to tackle it – The Guardian (free)

 

7 – The treatment of anal fistula: second ACPGBI Position Statement – 2018 – Colorectal Disease (free)

 

8 – Guidelines for the Evaluation and Treatment of Perimenopausal Depression: Summary and Recommendations – Journal of Women’s Health (free)

Commentaries: First-Ever Guidelines for Detecting, Treating Perimenopausal Depression – University of Illinois at Chicago, via NewsWise (free) AND Guidelines for Managing Perimenopausal Depression Now Available – MPR (free)

 

9 – A pilot study using telehealth to implement antimicrobial stewardship at two rural Veterans Affairs medical centers – Infection Control & Hospital Epidemiology (free)

News Release: Telehealth Proves Valuable for Promoting Safe Antibiotic Prescribing Practices in Remote Healthcare Settings – Society for Healthcare Epidemiology of America (free)

Commentary: VA pilot study finds telehealth could aid stewardship – CIDRAP (free)

 

10 – Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features – Cell (free)

Related Article: Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT – Cell (free)

Commentaries: Probiotics: Does the evidence match the hype? – Medical News Today (free) AND Probiotics labelled ‘quite useless’ – BBC (free)

 


Thu, September 6 – 10 Stories of The Day!

6 Sep, 2018 | 00:10h | UTC

 

1 – Ten Commandments of the 2018 ESC/ESH HTN Guidelines on Hypertension in Adults – European Heart Journal (free) (via @gonzaeperez)

 

2 – Rapid Recommendations: Prostate cancer screening with prostate-specific antigen (PSA) test: a clinical practice guideline – The BMJ (free)

Related guidelines: American Cancer Society Guideline for the Early Detection of Prostate Cancer (free) AND PSA-Based Prostate Cancer Screening in Men Aged 55-69 – American Academy of Family Physicians (free) AND USPSTF Recommendation Statement: Screening for Prostate Cancer (free guideline, editorial and commentaries)

 

3 – Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

See also: Guideline Update Summary (free)

 

4 – Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Baloxavir for Uncomplicated Influenza (free)

Commentary: New single-dose antiviral cuts flu symptoms, viral loads – CIDRAP (free)

 

5 – Perspective: “Precision” Public Health — Between Novelty and Hype – New England Journal of Medicine (free)

 

6 – Guidance: Writing Outpatient Clinic Letters to Patients – Academy of Medical Royal Colleges (free PDF)

Commentaries: Doctors told to ditch Latin and use ‘plain English’ – BBC News (free) AND New drive to encourage doctors to write to patients in plain English – The Guardian (free) AND Rx for British Doctors: Use Plain English Instead of Latin – The New York Times (free)

“Guidance suggests specialists should avoid Latin terms, acronyms and convoluted language” (from The Guardian)

 

7 – Subsegmental pulmonary embolism: anticoagulation or observation? – PulmCCM (free)

 

8 – Policy Statement: Recommendations for Prevention and Control of Influenza in Children, 2018–2019 – American Academy of Pediatrics (free)

News Release: AAP Issues Flu Vaccine Recommendations for 2018-2019 (free)

 

9 – Diclofenac use and cardiovascular risks: series of nationwide cohort studies – The BMJ (free)

Commentary: Diclofenac Again Tied to Major Cardiovascular Events – NEJM Physician’s First Watch (free) AND ‘A major safety concern’: World’s most common NSAID doubles CVD risk – Cardiovascular Business (free)

 

10 – Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease – PLOS One (free)

Commentaries: AI beats doctors at predicting heart disease deaths – The Francis Crick Institute, via ScienceDaily (free) AND Novel AI algorithm beats cardiologists’ models in predicting heart disease mortality – Cardiovascular Business (free)

 


Wed, September 5 – 10 Stories of The Day!

5 Sep, 2018 | 00:01h | UTC

 

1 – cOAlition S: Making Open Access a Reality by 2020 – Science Europe (free)

See also: 10 principles of Plan S (free PDF) AND Press Release (free PDF)

Commentaries: Radical open-access plan could spell end to journal subscriptions – Nature News (free) AND ‘Plan S’ and ‘cOAlition S’ – Accelerating the transition to full and immediate Open Access to scientific publications – European Commission (free) AND Science without publication paywalls: cOAlition S for the realisation of full and immediate Open Access – PLOS Biology (free)

“…free access to all scientific publications from publicly funded research is a moral right of citizens.” (from European Comission)

 

2 – Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children – JAMA Pediatrics (free)

Commentaries: CDC releases updated guideline on diagnosis and management of pediatric mTBI – Kennedy Krieger Institute, via EurekAlert (free) AND CDC Seeks to Standardize Mild TBI Management in Kids – MedPage Today (free registration required) AND New advice on kids’ concussions calls for better tracking – Associated Press (free) AND CDC issues first guidelines to treat youth concussions – CNN (free)

 

3 – Screening for Syphilis Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement – JAMA (free)

Editorial: Congenital Syphilis—Still a Shadow on the Land (free)

“The USPSTF recommends early screening for syphilis infection in all pregnant women. (A recommendation)”

 

4 – Experts brace for more super-resistant gonorrhea – CIDRAP (free)

 

5 – Perspective: Good Documentation – JAMA (free for a limited period)

“In this narrative medicine essay, the author, who transitioned from paper and pen to computer-generated electronic health record keeping wonders whether the self-select menu items ultimately dehumanizes both the patient and the physician.” (via @JAMA_current see Tweet)

 

6 – Margaret McCartney: A summary of four and a half years of columns in one column – The BMJ (free) (via @oncology_bg)

 

7 – 2018 Korean Clinical Imaging Guideline for Hemoptysis – Korean Journal of Radiology (free)

 

8 – Policy Statement: Child Passenger Safety – American Academy of Pediatrics (free)

News Release: AAP Updates Recommendations on Car Seats for Children (free)

Commentary: Children Should Remain in Rear-Facing Car Seats as Long as Possible – Physician’s First Watch (free)

 

9 – Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1·9 million participants – The Lancet Global Health (free)

Commentaries: Quarter of world’s population ‘not active enough to stay healthy’ – The Guardian (free) AND A quarter of adults are too inactive, putting health at risk – Reuters (free)

 

10 – Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Physician Burnout Poses Risks to Patient Safety – Psychiatric News Alert (free) AND Burnout in doctors doubles risk of patient safety incidents, study finds – Pulse (free)

 


Tue, September 4 – 10 Stories of The Day!

4 Sep, 2018 | 00:01h | UTC

 

1 – Guideline Summary: Medicines for Treatment Intensification in Type 2 Diabetes and Type of Insulin in Type 1 and Type 2 Diabetes in Low-Resource Settings: Synopsis of the World Health Organization Guidelines on Second- and Third-Line Medicines and Type of Insulin for the Control of Blood Glucose Levels in Nonpregnant Adults With Diabetes Mellitus – Annals of Internal Medicine (free)

Original Guideline: Guidelines on second-and third-line medicines and type of insulin for the control of blood glucose levels in non-pregnant adults with diabetes mellitus – World Health Organization (free PDF)

 

2 – Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus – The Journal of Rheumatology (free PDF)

Related Guidelines: The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (PANLAR) – Annals of Rheumatic Diseases (free)

 

3 – The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines – GUT (free)

 

4 – Perspective: Five of the scariest antibiotic-resistant bacteria in the past five years – The Conversation (free)

 

5 – Review: Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk – Journal of the American Heart Association (free)

 

6 – Review: Ischemia and No Obstructive Coronary Artery Disease (INOCA): What Is the Risk – Journal of the American Heart Association? (free)

 

7 – Ann Robinson’s research reviews, 3 September 2018 – The BMJ Opinion (free)

 

8 – Primary antifungal prophylaxis for cryptococcal disease in HIV‐positive people – Cochrane Library (free for a limited period)

Summary: Preventing cryptococcal disease in HIV-positive people – Cochrane Library (free)

Antifungal prophylaxis reduced the risk of developing and dying from cryptococcal disease. Therefore, where CrAG screening is not available, antifungal prophylaxis may be used in patients with low CD4 counts at diagnosis and who are at risk of developing cryptococcal disease.”

 

9 – Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission – JAMA Network Open (free)

Commentary: New prediction rule may help detect delirium at hospital admission – ACP Hospitalist (free)

 

10 – Strategy of endovascular versus open repair for patients with clinical diagnosis of ruptured abdominal aortic aneurysm: the IMPROVE RCT – Health Technology Assessment (free)

Commentary: Endovascular aortic repair (EVAR) surgery more beneficial for ruptured abdominal aortic aneurysms than open repair – NIHR Signal (free)

 


Mon, September 3 – 10 Stories of The Day!

3 Sep, 2018 | 01:33h | UTC

 

1 – Consensus document of the Italian Association of Medical Oncology and the Italian Society of Palliative Care on early palliative care – Tumori Journal (free PDF)

Related Video: Early Palliative Care: a video for health and care professionals – University of Edinburgh (free)

Related Systematic Review: Early palliative care for adults with advanced cancer – Cochrane Library (free) AND Summary: Early palliative care for adults with advanced cancer – Cochrane Library (free)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

2 – Podcast: #111: Hotcakes – Complementary Medicine in Cancer, Dosing Aspirin by Body Weight, Marijuana & Respiratory Symptoms, Penicillin Allergies and More! – The Curbsiders (free audio and summary)

 

3 – Review: Cardiorenal Syndrome Revisited – Circulation (free) (via @Abraham_RMI)

 

4 – “So, Blood Cultures… or No?” – Use of Blood Cultures in the ED – emDocs (free)

Related Review: How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections? A State-of-the Art – Frontiers in Microbiology (free)

 

5 – Government proposes energy drinks ban for children – BBC (free)

Related: England Proposes Ban on Selling Energy Drinks to Children – The New York Times (10 articles per month are free)

 

6 – Abraar Karan: Changing the way we communicate about patients – The BMJ Opinion (free) (via @NUNESDOC)

“Father of 2, retired car salesman and keen on football NOT the colon cancer in Bed 4 – social history brings humanity back to the bedside” (via @hospicedoctor see Tweet)

 

7 – American Epilepsy Society: Five Things Physicians and Patients Should Question – Choosing Wisely (free)

Commentary: Choosing Wisely: 5 Practices to Question When Treating Epilepsy – NEJM Physician’s First Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

8 – Antidepressants for treating depression in dementia – Cochrane Library (free for a limited period)

Summary: Antidepressants for treating depression in dementia – Cochrane Library (free)

“On the only measure of efficacy for which we had high-quality evidence (depression rating scale scores), antidepressants showed little or no effect.”

 

9 – The impact of exposure to air pollution on cognitive performance – Proceedings of the National Academies of Sciences (link to abstract – $ for full-text)

Commentaries: Air pollution could be making us less intelligent – Science Magazine (free) AND Air Pollution Exposure Harms Cognitive Performance, Study Finds – NPR (free) AND Air pollution may harm cognitive intelligence, study says – BBC (free) AND Pollution May Dim Thinking Skills, Study in China Suggests – New York Times (10 articles per month are (free) AND Air pollution is making you less intelligent, according to a new study – World Economic Forum (free)

 

10 – Kawasaki disease: guidelines of the Italian Society of Pediatrics, part I – definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase – Italian Journal of Pediatrics (free)

Part II: Treatment of resistant forms and cardiovascular complications, follow-up, lifestyle and prevention of cardiovascular risks (free)

Related guideline: Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association (free)

Related reviews: Dissecting Kawasaki disease: a state-of-the-art review – European Journal of Pediatrics (free) AND Diagnosis and Management of Kawasaki Disease – American Family Physician (free) AND Controversies in diagnosis and management of Kawasaki disease – World Journal of Clinical Pediatrics (free)

 


Thu, August 30 – 10 Stories of The Day!

30 Aug, 2018 | 00:03h | UTC

 

1 – ESC Council on hypertension position document on the management of hypertensive emergencies – European Heart Journal – Cardiovascular Pharmacotherapy (free) (@Abraham_RMI)

“Patients that lack acute hypertension-mediated end organ damage to the heart, retina, brain, kidneys, or large arteries do not have a hypertensive emergency and can be treated with oral BP-lowering agents and usually discharged after a brief period of observation.”

 

2 – ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)

 

3 – Guideline for the management of hip and knee osteoarthritis – Royal Australian College of General Practitioners (free PDF)

News Release: Updated osteoarthritis guideline designed to reduce unnecessary imaging and surgery (free)

Commentary: Australia hopes to reduce unnecessary imaging, surgery with updated osteoarthritis guidelines – Health Imaging (free)

“The Guideline for the management of knee and hip osteoarthritis,” offer up exercise and weight loss as a first line defense, and warn against costly treatments using glucosamine, opioids and arthroscopic surgery, said David Hunter, co-chair of the RACGP group responsible for the update.” (from Health Imaging)

 

4 – Opinion: Is one drink per day really unsafe? That new alcohol study, explained – VOX (free)

Related Commentary: Study Causes Splash, but Here’s Why You Should Stay Calm on Alcohol’s Risks – The New York Times (10 articles per month are free)

Original Article: Alcohol Use and Burden for 195 Countries and Territories (free study and commentaries)

 

5 – Earwax, Of All Things, Poses Unrecognized Risk In Long-Term Care – Kaiser Health News (free)

“Of all the indignities that come with aging, excessive earwax may be the most insidious… when it goes unrecognized, it can pose serious problems, especially for the 2.2 million people who live in U.S. nursing homes and assisted living centers.”

 

6 – #ESCCongress – Early Versus Standard Care Invasive Examination and Treatment of Patients with Non-ST-Segment Elevation Acute Coronary Syndrome: The VERDICT (Very EaRly vs Deferred Invasive evaluation using Computerized Tomography) – Randomized Controlled Trial – Circulation (free PDF)

Editorial: Timing of Intervention in Non ST Elevation Acute Coronary Syndromes: And the VERDICT is? (free PDF)

Commentaries: VERDICT: Very Early Invasive Coronary Angiography vs. Standard Care in NSTE-ACS Patients- American College of Cardiology (free) AND ESC: Early Invasive Strategy in NSTEMI Does Not Improve Outcomes – MedPage Today (free registration required) AND VERDICT: Very Early Invasive Angiography No Help Overall for NSTE ACS – TCTMD (free)

 

7 – #ESCCongress – Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data – The Lancet (free)

Commentaries: Imaging of coronary inflammation for cardiovascular risk prediction – The Lancet (free) AND New Imaging Biomarker of Coronary Inflammation Shows Prognostic Value Exceeding All Current Noninvasive Measures – Cleveland Clinic (free) AND Imaging biomarker can predict coronary inflammation – UPI (free)

 

8 – #ESCCongress – Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: MATRIX: 1-Year Results Confirm Superiority of Transradial PCI – TCTMD (free) AND Radial vs. Femoral Access for Angiography with or Without Bivalirudin in Patients with Acute Coronary Syndrome – NEJM Journal Watch (free for a limited period) AND ESC: Radial Access Tied to Better 1-Year Outcomes in ACS – MedPage Today (free registration required)

 

9 – #ESCCongress – Psychological Distress and Risk of Myocardial Infarction and Stroke in the 45 and Up Study: A Prospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Distress boosts heart attack and stroke risk – Medical News Today (free) AND High Mental Distress Tied to Heart Troubles – MedPage Today (free registration required)

 

10 – #ESCCongress – Deep forehead wrinkles may signal a higher risk for cardiovascular mortality – ESC Press Releases (free)

Commentaries: Forehead wrinkles – an early sign of cardiovascular disease? – Medical News Today (free) AND Excessive forehead wrinkles may be early sign of atherosclerosis – Cardiovascular Business (free)

 


Fri, August 31 – 10 Stories of The Day!

31 Aug, 2018 | 01:12h | UTC

 

1 – Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study – The BMJ (free)

Commentaries: Vitamin D: a pseudo-vitamin for a pseudo-disease – The Conversation (free) AND Fracture risk not linked to low vitamin D or calcium levels – OnMedica (free)

Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline)

 

2 – Bacterial Factors That Predict Relapse after Tuberculosis Therapy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Bacterial Factors That Predict Relapse after Antituberculosis Therapy – NEJM Resident 360 (free) AND MICs of Isoniazid, Rifampin May Predict Tuberculosis Relapse – Drugs.com (free) AND Variation in bacterial drug susceptibility tied to TB relapse risk – CHEST Physician (free)

 

3 – Revisiting the timetable of tuberculosis – The BMJ (free)

Related: Soumya Swaminathan: TB programmes should focus on people with highest risk of progression to disease – The BMJ Opinion (free)

 

4 – Clinical Decisions: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome – New England Journal of Medicine (free)

 

5 – 2018 STD Prevention Conference – Centers for Disease Control and Prevention (free)

Press Release: New CDC analysis shows steep and sustained increases in STDs in recent years (free)

Commentaries: 5 reasons why 3 STDs are roaring back in America – VOX (free) AND Rates of three STDs in US reach record high, CDC says – CNN (free) AND Record High Number Of STD Infections In U.S., As Prevention Funding Declines – NPR (free) AND STD cases in U.S. hit record highs as officials warn about resistant gonorrhea – STAT (free) AND US sees record STD cases, rising gonorrhea resistance – CIDRAP (free)

 

6 – Clinical Implications and Challenges of Artificial Intelligence and Deep Learning – JAMA (free for a limited period)

Related Viewpoints: Deep Learning—A Technology With the Potential to Transform Health Care – JAMA (free for a limited period) AND Deep Learning—A Technology With the Potential to Transform Health Care – JAMA (free for a limited period)

 

7 – Publication: Immigration as a Social Determinant of Health: Proceedings of a Workshop – National Academies of Sciences, Engineering, and Medicine (free PDF)

“Immigration as a social determinant of health – NEW publication explores complex interactions between immigration and health disparities + grappling with the complexities of immigration” (via @julianmfisher see Tweet)

 

8 – Optimal Blood Pressure Target in Diabetic and Nondiabetic Hypertensive Patients – Circulation Research (free)

See counterpoint suggesting lower BP targets: Sprinting Toward the Optimal Blood Pressure Target for Hypertensive Patients – Circulation Research (free)

“We have reviewed the randomized trial evidence in favor of a target blood pressure (BP) around 130/80 mm Hg in hypertensive patients with and without diabetes mellitus”

 

9 – Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis – The BMJ (free)

Editorial: Environmental metals and cardiovascular disease (free)

Commentary: Experts warn of cardiovascular risk from heavy metal pollution – University of Cambridge (free)

“Since metals are associated with cardiovascular disease even at relatively low levels of exposure, population wide strategies to minimize exposure can further contribute to overall cardiovascular prevention efforts” (from @bmj_latest see Tweet)

 

10 – Functional Status and Survival After Breast Cancer Surgery in Nursing Home Residents – JAMA Surgery (free for a limited period)

Commentaries: Surgical Decision Making in Elderly, Impaired Nursing Home Patients – JAMA Surgery (free for a limited period) AND For Nursing Home Patients, Breast Cancer Surgery May Do More Harm Than Good – Kaiser Health News (free)

 


Wed, August 29 – 10 Stories of The Day!

29 Aug, 2018 | 00:01h | UTC

 

1 – Report: Crossing the Global Quality Chasm: Improving Health Care Worldwide – National Academies Of Sciences, Engineering, and Medicine (free PDF)

News Release: Up to 8 Million Deaths Occur in Low- and Middle-Income Countries Yearly Due to Poor-Quality Health Care, Says New Report; Major Quality Chasm Must Be Fixed in Order to Reap Benefits of Universal Health Coverage (free)

Videos: The Scope of the Problem (free) AND Health Systems of the Future (free)

See also: Report Highlights (free PDF) AND Recommendations (free PDF)

 

2 – #ESCCongress – Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis – New England Journal of Medicine (free for a limited period)

Commentaries: Partial Oral Treatment of Endocarditis – POET – American College of Cardiology (free) AND New treatment can halve hospital stays for some patients with heart infection – ESC Press Releases (free)

 

3 – #ESCCongress – High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial – The Lancet (free)

Commentaries: Diagnosing myocardial infarction: a highly sensitive issue – The Lancet (free) AND Hs-TnI in Suspected ACS: High-STEACS Trial – American College of Cardiology (free)

Introduction of a high-sensitivity cardiac troponin I assay reclassified 1 in 6 patients with previously undetected myocardial necrosis, but did not lead to improved clinical outcomes in this large randomised trial” (via @chapdoc1 see Tweet)

Very important study. What’s weird is that the “better” (more sensitive) troponin assays get, the less helpful the test becomes at the bedside. Look for a coming tsunami of iatrogenesis from overzealous evaluation of troponin bumps.” (via @drjohnm see Tweet)

 

4 – #ESCCongress – One-Year Outcomes after PCI Strategies in Cardiogenic Shock – New England Journal of Medicine (free for a limited period)

Commentaries: Less Is Still More in Patients with Acute Myocardial Infarction and Cardiogenic Shock – NEJM Journal Watch (free for a limited period) AND 1-year outcomes still support culprit-only PCI for cardiogenic shock – Cardiovascular Business (free) AND CULPRIT-SHOCK: 1-Year Results Continue to Support Culprit-Only PCI for Shock Patients – TCTMD (free)

 

5 – #ESCCongress – Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Telemedicine in Heart Failure Patients (TIM-HF2) – American College of Cardiology (free) AND ESC: Telemonitoring of HF Cuts Admissions, Mortality MedPage Today (free registration required)

 

6 – Global Mortality From Firearms, 1990-2016 – JAMA (free for a limited period)

Video Summary: Global Firearm Mortality, 1990-2016 – JAMA (free)

Infographic: Firearm deaths around the world 1990–2016 – Institute for Health Metrics and Evaluation (free) (via @kleachkemon)

Commentaries: Six countries in the Americas account for half of all firearm deaths – Institute for Health Metrics and Evaluation (free) AND Gun-related homicides, suicides kill more people than war, study says – CNN (free)

 

7 – Zackary Berger’s journal reviews, 28 August 2018 – The BMJ Opinion (free)

 

8 – Guide to Statistics and Methods: Case-Control Studies: Using “Real-world” Evidence to Assess Association – JAMA (free for a limited period)

 

9 – Guiding Principles for the Care of People With or at Risk for Diabetes – National Institute of Diabetes and Digestive and Kidney Diseases (free PDF)

Commentaries: NIDDK Updates ‘Guiding Principles’ for Diabetes, Prediabetes – Medscape (free registration required) AND NDEP revises principles for managing diabetes, prediabetes – Cardiovascular Business (free)

Related Book: Diabetes in America, 3rd Edition – National Institutes of Health (free reference book, just released)

 

10 – Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015 – Nature Human Behavior (free for a limited period)

Commentaries: More social science studies just failed to replicate. Here’s why this is good – VOX (free) AND High-profile journals put to reproducibility test – Nature News (free) AND ‘Replication crisis’ spurs reforms in how science studies are done – ScienceNews (free) AND The Science Behind Social Science Gets Shaken Up—Again – WIRED (Free) AND In Psychology And Other Social Sciences, Many Studies Fail The Reproducibility Test – NPR (free)

We replicated 21 social science experiments in Science or Nature. We succeeded with 13. Replication effect sizes were half of originals.” (via @BrianNosek see Tweet)

 


Tue, August 28 – 10 Stories of The Day!

28 Aug, 2018 | 00:01h | UTC

 

1 – Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal (free)

Commentaries: Care coordination improves health of older patients with multiple chronic diseases – CMAJ, via EurekAlert (free) AND Seniors healthier when medical care is coordinated – Reuters (free)

Related: Ten Recommendations: Designing a High-Performing Health Care System for Patients with Complex Needs (free Guidance and related perspectives) AND Multimorbidity: A Priority for Global Health Research (free research and commentaries)

 

2 – A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction – Circulation (free) (via @CircAHA see Tweet with Infographic)

Editorial: H2FPEF Score: At Last, a Properly Validated Diagnostic Algorithm for Heart Failure With Preserved Ejection Fraction (free)

 

3 – Clinical Guideline Synopsis: Diagnosis and Treatment of Clostridium difficile Infection – JAMA (free for a limited period) (via @ABsteward and @Abraham_RMI)

Original Guideline: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free)

 

4 – Review: Acute Clinical Care for Transgender Patients – JAMA Internal Medicine (free for a limited period) (via @CarlosdelRio7)

 

5 – Antithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report (free PDF)

News Release: The American College of Chest Physicians updates their antithrombotic therapy guidelines for patients with atrial fibrillation (free)

 

6 – Clinical Report: Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes – Pediatrics (free)

News Release: Counsel against marijuana use in pregnancy, breastfeeding – American Academy of Pediatrics (free)

Related Article: Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk – Pediatrics (free)

Commentaries: A Modern Conundrum for the Pediatrician: The Safety of Breast Milk and the Cannabis-Using Mother – Pediatrics (free) AND Marijuana study finds THC in breast milk up to 6 days after mom’s use – CNN (free) AND Pediatricians Put It Bluntly: Motherhood And Marijuana Don’t Mix – Kaiser Health News (free) AND Clinical report provides guidance on marijuana use in pregnancy and lactation – 2 Minute Medicine (free)

 

7 – #ESCCongress – Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus – New England Journal of Medicine (free for a limited period)

Commentaries: Fish oils do not prevent heart attack or strokes in people with diabetes – ESC News Releases (free) AND Omega-3 Fatty Acids Fail to Reduce CVD Events in Diabetic Patients: ASCEND – TCTMD (free)

Related Cochrane Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (link to abstract and commentaries)

Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free study and commentary)

 

8 – #ESCCongress – Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients – New England Journal of Medicine (free for a limited period)

Editorial: Lorcaserin — Elixir or Liability? (free for a limited period)

Commentaries: CAMELLIA-TIMI 61: Weight Loss Drug Lorcaserin Did Not Increase CV Events – American College of Cardiology (free) AND Weight-Loss Drug Lorcaserin Clears Cardiovascular Safety Hurdle: CAMELLIA-TIMI 61 – TCTMD (free) AND Weight loss drug lorcaserin found safe in large study – Reuters (free)

 

9 – #ESCCongress – Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness – New England Journal of Medicine (free for a limited period)

Commentaries: VTE risk unchanged by rivaroxaban after discharge – The Hospitalist (free) AND MARINER: Rivaroxaban vs. Placebo Post-Discharge in Patients at High Risk For VTE – American College of Cardiology (free) AND MARINER: No Reduction in Death, VTE With Rivaroxaban After Discharge in Medically Ill Patients – Medscape (free registration required)

 

10 – #ESCCongress – Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy – New England Journal of Medicine (free for a limited period)

Editorial: Stabilizing Transthyretin to Treat ATTR Cardiomyopathy (free for a limited period)

Commentaries: Tafamidis, a Transthyretin Stabilizer, Offers Hope for Rare Cardiomyopathy – TCTMD (free) AND ATTR-ACT: Tafamidis Findings Offer Hope For Patients With ATTR-CM – American College of Cardiology (free) AND Drug reduces deaths and hospitalizations from underdiagnosed form of heart failure – Columbia University Irving Medical Center, via EurekAlert (free)

 


Fri, August 24 – 10 Stories of The Day!

24 Aug, 2018 | 00:01h | UTC

 

1 – Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet (free)

Commentaries: No level of alcohol consumption improves health – The Lancet (free) AND No amount of alcohol is good for your overall health, global study says – CNN (free) AND New scientific study: no safe level of alcohol – Institute for Health Metrics and Evaluation (free)

“Alcohol was responsible for nearly 3 million deaths in 2016, the study says. It was the leading risk factor for disease and premature death in men and women between the ages of 15 and 49 worldwide in 2016, accounting for nearly one in 10 deaths.” (from @cnni see Tweet)

 

2 – Antibiotics should not be issued as first line of treatment for a cough, says NICE and PHE – NICE News and Features (free)

Commentaries: Promote honey rather than antibiotics for coughs, doctors told – The Guardian (free) AND Use honey first for a cough, new guidelines say – BBC (free)

Related: Honey for acute cough in children – Cochrane Library (free systematic review and commentary)

 

3 – How scientists are learning to predict your future with your genes – VOX (free) (via @EricTopol)

There’s not one light switch but hundreds, each with the ability to slightly increase or decrease the chances of developing the illness.”

 

4 – Perspective: Adolescents’ Use of “Pod Mod” E-Cigarettes — Urgent Concerns – New England Journal of Medicine (free)

 

5 – A Late-Life Surprise: Taking Care Of Frail, Aging Parents – Kaiser Health News (free)

 

6 – Viewpoint: The Challenge of Reforming Nutritional Epidemiologic Research – JAMA (free)

“…the emerging picture of nutritional epidemiology is difficult to reconcile with good scientific principles. The field needs radical reform.”

 

7 – Review: Difficult tracheal intubation in critically ill – Journal of Intensive Care (free)

 

8 – Glucocorticoids for croup in children – Cochrane Library (free for a limited period)

Summary: Glucocorticoids for croup in children – Cochrane Library (free)

Commentary: Glucocorticoid Therapy Examined in Pediatric Patients With Croup – MPR (free)

 

9 – Risk of Esophageal Adenocarcinoma After Antireflux Surgery in Patients With Gastroesophageal Reflux Disease in the Nordic Countries – JAMA Oncology (free for a limited period)

 

10 – Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia – JAMA (link to abstract – $ for full-text)

Commentaries: Study confirms that keeping the heart healthy also reduces dementia risk – NHS Choices (free) AND The Healthier Your Heart, the Healthier Your Brain May Be – The New York Times (10 articles per month are free) AND Cardiovascular Risk Factors Also Linked to Dementia – MedicalResearch.com (free) AND Reducing CV Risk May Improve Brain Health at Any Stage in Life, Studies Hint – TCTMD (free)

 


Mon, August 27 – 10 Stories of The Day!

27 Aug, 2018 | 00:44h | UTC

 

#ESCCongress – Highlights from the 2018 Meeting of the European Society of Cardiology

 

 

1 – #ESCCongress – 2018 ESC/ESH Guidelines for the management of arterial hypertension – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

2 – #ESCCongress – 2018 ESC/EACTS Guidelines on myocardial revascularization – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

3 – #ESCCongress – Fourth universal definition of myocardial infarction (2018) – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

4 – #ESCCongress – 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

5 – #ESCCongress – Recommendations for participation in competitive sports of athletes with arterial hypertension: a position statement from the sports cardiology section of the European Association of Preventive Cardiology (EAPC) – European Heart Journal (free)

 

6 – #ESCCongress – Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery – New England Journal of Medicine (free for a limited period)

In moderate-to-high-risk patients undergoing cardiac surgery, six-month outcomes show that a restrictive red-cell transfusion strategy is noninferior to a liberal strategy” (via @NEJM see Tweet with Visual Abstract)

 

7 – #ESCCongress – CLARIFY: No Survival Benefit With Beta-Blockers Beyond 1 Year Post-MI in Stable CAD – TCTMD (free)

Related Study: B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction (free study and commentary)

“The problem, said Sorbets, is that there have never been large randomized trials to test the prognostic effects of beta-blockers in this patient group and instead, recommendations have been drawn from meta-analyses using data extracted from the acute MI setting or from observational studies.”

 

8 – #ESCCongress – Coronary CT Angiography and 5-Year Risk of Myocardial Infarction – New England Journal of Medicine (free for a limited period)

Commentary: Five Reasons I Don’t Believe an Imaging Test Improves Outcomes – by Dr. John Mandrola, in Medscape (free registration required)

See also an interesting Tweetorial by @AnilMakam, also suggesting caution before adopting this study results in clinical practice.

 

9 – #ESCCongress – Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus – New England Journal of Medicine (free for a limited period)

Commentaries: Bleeds and benefit with aspirin balanced in patients with diabetes and no effect on cancer – ESC Press Releases (free) AND  ASCEND: Aspirin Doesn’t Look Good for Primary CV Prevention in Diabetic Patients – TCTMD (free)

 

10 – #ESCCongress – Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Aspirin Fails to Prevent CV Events in People at ‘Moderate’ Risk of Disease: ARRIVE – TCTMD (free) AND ARRIVE: New Findings Contribute to Growing Body of Evidence Surrounding Aspirin Use – American College of Cardiology (free) AND Daily Aspirin Fails to Lower CV Risk in Long-term, Primary Prevention ARRIVE Trial – Medscape (free registration required) AND Jury still out on aspirin a day to prevent heart attack and stroke – ESC Press Releases (free)

 


Wed, August 22 – 10 Stories of The Day!

22 Aug, 2018 | 00:01h | UTC

 

1 – Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Related articles: Screening for Cervical Cancer With High-Risk Human Papillomavirus Testing: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA (free) AND Screening for Cervical Cancer in Primary Care: A Decision Analysis for the US Preventive Services Task Force – JAMA (free)

Editorials: Screening for Cervical Cancer: New Tools and New Opportunities (free for a limited period) AND Cervical Cancer Screening—Moving From the Value of Evidence to the Evidence of Value (free for a limited period)

Author Interview: USPSTF Recommendation: Screening for Cervical Cancer (free)

Final Update Summary: Cervical Cancer: Screening – US Preventive Service Task Force (free)

Commentaries: Cervical cancer screening without Pap test OK for some women – Reuters (free) AND For Cervical Cancer Screening, Women Over 30 Can Now Choose The HPV Test Only – NPR (free) AND Annual Pap Test a ‘Thing of the Past?’ – Florida Atlantic University (free)

 

2 – Joint Consensus Document: Management of antithrombotic therapy in AF patients presenting with ACS and/or undergoing PCI – European Heart Journal (free)

 

3 – CSI position statement on management of heart failure in India – Indian Heart Journal (free)

 

4 – 2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation – World Journal of Emergency Surgery (free)

 

5 – The Japanese Clinical Practice Guideline for acute kidney injury 2016 – Journal of Intensive Care (free)

 

6 – Our first year together – World Health Organization (free)

“Delighted to share my first annual letter as WHO Director-General. It outlines our major achievements over the past year and what I believe are the keys to achieving #HealthForAll. I’m proud of everything we’ve achieved – but we’re just getting started!” (via @DrTedros see Tweet)

 

7 – How smartphones are becoming a weapon in the global fight against tuberculosis – STAT (free)

 

8 – Long-Term Association of Low-Density Lipoprotein Cholesterol With Cardiovascular Mortality in Individuals at Low 10-Year Risk of Atherosclerotic Cardiovascular Disease – Circulation (free)

Commentaries: ‘Bad’ cholesterol can be deadly in otherwise healthy people – AHA News (free) AND LDL >160 Tied to Increased Mortality in Low-Risk Patients – Physician’s First Watch (free) AND Study: Elevated LDL, non-HDL increase CVD mortality risk in young, healthy individuals – Cardiovascular Business (free) AND Moderate ‘bad cholesterol’ levels tied to early death for healthy people – Reuters (free)

 

9 – Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials – Critical Care (free)

Commentary: Procalcitonin guidance linked to improved sepsis survival – Univadis (free registration required)

 

10 – Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Pregabalin may increase the risk of death when coprescribed with opioids – 2 Minute Medicine (free) AND Pregabalin Linked To Increased Risk for Opioid-Related Deaths – MedicalResearch.com (free) AND Anticonvulsant With Opioids Tied To Higher Mortality – MedPage Today (free registration required)

 


Tue, August 21 – 10 Stories of The Day!

21 Aug, 2018 | 01:55h | UTC

 

1 – Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association – Circulation (free PDF)

AHA News Release: Chagas disease, caused by a parasite, has spread outside of Latin America and carries a high risk of heart disease (free)

Top Ten Things to Know: Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management (free PDF)

 

2 – Clinical Report: The Power of Play: A Pediatric Role in Enhancing Development in Young Children – Pediatrics (free)

News Release: Want Creative, Curious, Healthier Children with 21st Century Skills? Let Them Play – American Academy of Pediatrics (free)

Commentary: It’s come to this: A checkup with the pediatrician may soon include a prescription for play – Los Angeles Times (free) AND Let Kids Play – The New York Times (10 articles per month are free) AND AAP Report Highlights Importance of Children’s Play for Development – Journal Watch (free)

 

3 – Rapid Communication: Key changes to treatment of multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) – World Health Organization (free PDF)

News Release: WHO announces landmark changes in MDR-TB treatment regimens (free)

Commentary: WHO revises MDR-TB treatment with focus on oral drugs – CIDRAP (free)

 

4 – Measles cases hit record high in the European Region – World Health Organization (free)

Commentaries: Measles cases hit record high in Europe – BBC (free) AND Expert reaction to measles cases in Europe – Science Media Centre (free) AND Low MMR uptake blamed for surge in measles cases across Europe – The Guardian (free) AND Measles cases reach record high in Europe – CNN (free)

 

5 – Assessment of the Safety of Discharging Select Patients Directly Home From the Intensive Care Unit: A Multicenter Population-Based Cohort Study – JAMA Internal Medicine (free for a limited period)

Invited Commentary: The Complexity and Challenges of Intensive Care Unit Admissions and Discharges: Similarities With All Hospitalized Patients – JAMA Internal Medicine (free for a limited period)

 

6 – Clinical Update: Management of Groin Hernias in Adults—2018 – JAMA (free for a limited period)

 

7 – Perspective: This Drug Is Safe and Effective. Wait. Compared With What? – The New York Times (10 articles per month are free)

 

8 – Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years – JAMA Pediatrics (free)

“Rotavirus-associated mortality has decreased by 48.2% in children under 5 between 1990 and 2016” (via @IHME_UW see Tweet with infographics)

 

9 – Optimising first- and second-line treatment strategies for untreated major depressive disorder — the SUND study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial – BMC Medicine (free)

 

10 – Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department – Canadian Medical Association Journal (free)

Commentaries: Simple score to diagnose heart attacks is safer, faster than current methods – McMaster University (free) AND Clinical Chemistry Score Helps Rule Out Diagnosis of Heart Attack – MedicalResearch.com (free)

 


Mon, August 20 – 10 Stories of The Day!

20 Aug, 2018 | 00:01h | UTC

 

1 – Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial – The Lancet (free)

Invited commentary: Helping children with hearing loss from otitis media with effusion – The Lancet (free)

“Short-course oral prednisolone is not an effective treatment for most children aged 2–8 years with persistent otitis media with effusion but is well tolerated—findings from OSTRICH, the first placebo-controlled trial” (via @TheLancet see Tweet)

 

2 – Report: E-Cigarettes – House of Commons Science and Technology Committee (free PDF)

Commentaries: Stop treating e-cigs like conventional cigarettes, MPs tell NHS – OnMedica (free) AND E-cigarettes can be key weapon against smoking, say MPs – BBC (free)

See also: related guidelines, reports and commentaries on e-cigarettes (all free)

 

3 – Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis – Critical Care Medicine (free)

Related: Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)

 

4 – Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It – The New York Times (10 articles per month are free) (via @CarlosdelRio7 see Tweet)

Related commentaries: Vitamin D Screening and Supplementation in Primary Care: Time to Curb Our Enthusiasm – American Family Physician (free) AND Your vitamin D tests and supplements are probably a waste of money – VOX (free) AND Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

Related Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (free)

“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk” (from NICE Guideline)

 

5 – Too Much Medicine: A small medical conference with a big impact – HealthNewsReview (free)

 

6 – Review: Intravenous fluid therapy in critically ill adults – Nature Reviews Nephrology (free for a limited period) (via @CritCareReviews)

 

7 – Review: Airway and ventilation management during cardiopulmonary resuscitation and after successful resuscitation – Critical Care (free)

 

8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentaries: WHO Expects Ebola To Spread In Congo In Areas Too Dangerous To Send Workers – NPR (free) AND Health worker among 5 new cases in DRC Ebola outbreak – CIDRAP (free) AND Militia threat hampers Ebola fight in Congo as disease kills 47 – Reuters (free)

 

9 – Association of Body Mass Index With Blood Pressure Among 1.7 Million Chinese Adults – JAMA Network Open (free)

Commentary: As body mass index increases, blood pressure may as well – Yale University (free)

 

10 – Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis – The Lancet Public Health (free)

Commentaries: Evolving evidence about diet and health – The Lancet Public Health (free) AND Expert reaction to study looking at carbohydrate intake and health – Science Media Centre (free) AND Moderate carbohydrate intake may be best for health, study suggests – The Lancet, via ScienceDaily (free) AND Low-carb diets could shorten life, study suggests – BBC (free)

 


Thu, August 23 – 10 Stories of The Day!

23 Aug, 2018 | 00:12h | UTC

 

1 – Podcast: #109: Things We Do For No Reason: A High Value Episode – The Curbsiders (free audio and summary)

Related Series: Choosing Wisely: Things We Do For No Reason – Journal of Hospital Medicine (some free articles)

 

2 – Perspective: Outbreaks in a Rapidly Changing Central Africa — Lessons from Ebola – New England Journal of Medicine (free)

Related: Experimental Ebola treatments OK’d in DRC as cases top 100 – CIDRAP (free) AND Congo approves more experimental Ebola treatments as cases rise – Reuters (free)

 

3 – Sport Specialization and Risk of Overuse Injuries: A Systematic Review With Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentary: Sport specialization tied to injuries in kids and teens – Reuters (free)

 

4 – Asthma and COPD Overlap in Women: Incidence and Risk Factors – Annals of the American Thoracic Society (link to abstract – $ for full-text)

Commentaries: More than 40 percent of women with asthma may develop COPD, but risk may be reduced – Annals of Thoracic Society (free) AND Four in 10 women with asthma may develop COPD – Reuters (free) AND Four in 10 women with asthma may develop COPD – OnMedica (free)

 

5 – Perspective: Exploring the Relationship Between Depression and Dementia – JAMA (free for a limited period)

 

6 – Association Between Electronic Cigarette Use and Myocardial Infarction – American Journal of Preventive Medicine (free for a limited period)

Commentary: Risk of heart attacks is double for daily e-cigarette users – University of California – San Francisco, via ScienceDaily (free)

“New analysis shows five-fold risk for people who use both cigarettes and e-cigarettes daily”

 

7 – Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) – Cochrane Library (free for a limited period)

Summary: Phosphate binders to prevent complications of chronic kidney disease – Cochrane Library (free)

 

8 – Extended antibiotic infusions could save lives: Here’s how to do it – PulmCCM (free)

Related Research: Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (free)

The simplest (and cheapest) technique is simply to reduce the time between doses.”

 

9 – Seven days of antibiotics were as good as 14 for gram-negative bacteremia – PulmCCM (free)

Related Commentary: Seven-day antibiotic course delivers similar outcomes to 14-days for Gram-negative bacteraemia – European Society of Clinical Microbiology and Infectious Diseases, via EurekAlert (free)

“It’s important to note that source control was believed to be achieved in all enrolled patients. If source control cannot be achieved (e.g., an abscess, or an infected heart valve or indwelling catheter that cannot safely be removed), prolonged antibiotic courses are often advisable.”

 

10 – Breastfeeding History and Risk of Stroke Among Parous Postmenopausal Women in the Women’s Health Initiative – Journal of the American Heart Association (free)

Commentaries: Breastfeeding linked to lower stroke risk – Reuters (free) AND Breastfeeding may help protect mothers against stroke – AHA News (free)

“…ultimately, the study is observational, which means that it can only prove that breastfeeding is associated with lower risk of stroke as opposed to being the cause of the lowered risk.” (from Reuters)

 


Fri, August 17 – 10 Stories of The Day!

17 Aug, 2018 | 01:16h | UTC

 

1 – 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease (free PDF)

News Release: Societies Release Updated Guideline for Treating Adult Congenital Heart Disease Patients (free)

Key Points to Remember: 2018 AHA/ACC Guideline for Adults With Congenital Heart Disease – American College of Cardiology (free)

 

2 – Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU – Critical Care Medicine (free) (via @Abraham_RMI)

 

3 – Association of Compensation From the Surgical and Medical Device Industry to Physicians and Self-declared Conflict of Interest – JAMA Surgery (free for a limited period)

Author Interview: Association of Compensation to Physicians From Industry and Self-declared Conflict of Interest (free)

Commentaries: Safeguarding Against Conflicts of Interest in the Surgical Literature – JAMA Surgery (free for a limited period) AND Financial Ties That Bind: Studies Often Fall Short On Conflict-Of-Interest Disclosures – Kaiser Health News (free)

 

4 – Recent trends in life expectancy across high income countries: retrospective observational study – The BMJ (free)

Editorial: Reversals in life expectancy in high income countries? (free for a limited period)

Commentaries: Life Expectancy Declining Across High Income Countries – Eurasia Review (free) AND Australians living longer but life expectancy dips in US and UK – The Guardian (free) AND UK life expectancy drops while other western countries improve – NHS Choices (free)

 

5 – Changes in midlife death rates across racial and ethnic groups in the United States: systematic analysis of vital statistics – The BMJ (free)

Infographic: Why is US Life Expectancy Falling Behind? (free PDF)

Commentary: Life expectancy drops in the US and the UK, rises in Australia, a new study finds – CNN (free)

 

6 – Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD (free)

Related: Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free) AND Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

 

7 – Effect of Peer Comparison Letters for High-Volume Primary Care Prescribers of Quetiapine in Older and Disabled Adults: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Behavioral nudges lead to striking drop in prescriptions of potent antipsychotic – Columbia University’s Mailman School of Public Health, via ScienceDaily (free) AND Study Reduces Over-prescription of Antipsychotics in Older Adults – Mad in America (free) AND ‘Dear Doctor’ Letters Use Peer Pressure, Government Warning To Stop Overprescribing – NPR (free) AND Peer Pressure Tactic Successfully Curbs Overprescribing – Medscape (free registration required)

 

8 – Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality – The New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Weight gain after smoking cessation linked with increased short-term diabetes risk – Harvard T.H. Chan School of Public Health (free) AND Weight gain temporarily hikes diabetes risk when smokers quit – Reuters (free) AND Smokers Are Better Off After They Quit Even if They Gain Weight – Physician’s First Watch (free)

 

9 – Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free for a limited period)

Summary: Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free)

 

10 – Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Autism and DDT: What one million pregnancies can — and can’t — reveal – Nature News (free) AND Epidemiologists Link DDT From The 1970s To Modern Autism Diagnoses – Science 2.0 (free – skeptical point of view on study results)

 


Wed, August 15 – 10 Stories of The Day!

15 Aug, 2018 | 02:32h | UTC

 

1 – State of the Art Review: Overdiagnosis in primary care: framing the problem and finding solutions – The BMJ (free for two weeks)

 

2 – Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations – Nature Genetics (link to abstract – $ for full-text)

Commentaries: Researchers predict risk for common deadly diseases from millions of genetic variants – Broad Institute of MIT and Harvard, ScienceDaily (free) AND Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA – The New York Times (10 articles per month are free) AND Multi-gene test may find risk for heart disease and more – Associated Press (free) AND A Harvard Scientist Thinks He Has a Gene Test for Heart Attack Risk. He Wants to Give It Away Free – Forbes (free)

  

3 – Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Fixed-Dose Combination Pill for Hypertension Treatment in Sri Lanka (free)

Commentaries: Three-in-one pill lowers blood pressure significantly, study say – UPI (free) AND Innovative triple pill significantly lowers blood pressure, study finds – George Institute for Global Health, via EurekAlert (free)

 

4 – Richard Smith: The polypill and the long journey to major impact – The BMJ Opinion (free)

Related Reviews: Strengths and Limitations of Using the Polypill in Cardiovascular Prevention – Current Cardiology Reports (free) AND The polypill approach – An innovative strategy to improve cardiovascular health in Europe – BMC Pharmacology and Toxicology (free)

 

5 – Cancer in People Living with HIV – NCCN Clinical Practice Guidelines in Oncology – Journal of the National Cancer Center Network (free)

 

6 – Opinion: Lessons for physicians from ‘The Bleeding Edge’: If you see something, say something – STAT (free)

“…physicians must act decisively when they identify the rare outlier in their midst. To do anything less would risk our credibility. Worse still, it could risk the lives of the people we took an oath not to harm.”

 

7 – Yoga, Depression, & Clinical Trial Critique 101 – Hilda Bastian, in Absolutely Maybe Blog (free)

“5 steps to unpack a randomized trial!” (via @hildabast, see Tweet)

 

8 – DRC Ebola cases surpass earlier outbreak total, virus infects 4 more health workers – CIDRAP (free)

Related: DRC may provide model for containing future Ebola outbreaks – The Conversation (free)

 

9 – Book: Diabetes in America, 3rd Edition – National Institutes of Health (free chapters)

News Release: New NIH reference book is one-stop resource for diabetes medical information – National Institutes of Health (free)

 

10 – Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews – Cochrane Library (free)

Summary: Treatments to improve pregnancy outcomes for women who develop diabetes during pregnancy: an overview of Cochrane systematic reviews – Cochrane Library (free)

 


Thu, August 16 – 10 Stories of The Day!

16 Aug, 2018 | 00:15h | UTC

 

1 – Risk Factors, Mortality, and Cardiovascular Outcomes in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: In Type 2 Diabetes, Five Risk Factor Targets Keep MI, Stroke, and Death in Check – TCTMD (free) AND How People With Type 2 Diabetes Can Lower Their Risk of Health Problems – TIME (free) AND T2D, Without Other Risks, Not Tied to Excess Mortality – MedPage Today (free registration required)

 

2 – Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data – The Lancet Neurology (free)

Commentary: Brain scan checklist set to boost care for stroke survivors – University of Edinburgh, via EurekAlert (free)

 

3 – Trends in Use of Daily Chest Radiographs Among US Adults Receiving Mechanical Ventilation – JAMA Network Open (free)

Commentaries: Daily Chest X-Rays Still Overused in Mechanically Ventilated Patients – MedicalResearch.com (free) AND Routine daily CXRs for ventilated patients: de-adoption is lagging – Univadis (free registration required) AND Chest x-rays overused on ventilation patients despite ACR guideline – HealthImaging (free)

 

4 – Editorial: Making diagnostic tests as essential as medicines – BMJ Global Health (free)

Related: Report: First-ever WHO List of Essential Diagnostic Tests (free report and news release) AND The WHO Essential Diagnostic List: A Tool for the Future (free commentaries)

 

5 – How Unpaywall is transforming open science – Nature News (free)

Related: Unlocking paywalled research papers (legally) (free commentaries) AND Half of papers searched for online are free to read (free)

We have been using the Unpaywall Extension for a while, and it is indeed a handy tool to find free versions (entirely legal) of paywalled articles.

 

6 – Long-Term Prognosis of Patients With Takotsubo Syndrome – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Long-Term Prognosis of Takotsubo Syndrome – American College of Cardiology (free) AND How deadly is Takotsubo syndrome? It depends on the trigger – Cardiovascular Business (free)

Related: International Expert Consensus Document on Takotsubo Syndrome (free)

 

7 – Perspective: Medical students are skipping class in droves — and making lectures increasingly obsolete – STAT (free)

 

8 – Ebola virus disease in the Democratic Republic of the Congo – Operational readiness and preparedness in neighbouring countries – World Health Organization (free)

Related: WHO chief calls for end to fighting in Congo to halt Ebola spread – The Guardian (free) AND Ebola cases mounting in DRC as region prepares for more – CIDRAP (free)

 

9 – Association Between Traumatic Brain Injury and Risk of Suicide – JAMA (link to abstract – $ for full-text)

Commentaries: Traumatic brain injury tied to increased risk of suicide – Reuters (free) AND Risk of Suicide Increases After TBI, Study Finds – Psychiatric News Alert (free) AND Expert reaction to traumatic brain injury and suicide – Science Media Centre (free)

 

10 – Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Switching Anti-Psychotic Medications Doesn’t Improve Outcomes in First-Episode Schizophrenia Patients – Mount Sinai (free) AND No Benefit of Switching Antipsychotics in Early Schizophrenia – Medscape (free registration required) AND No Gain with Antipsych Meds Switch in Schizophrenia – MedPage Today (free registration required)

 


Tue, August 14 – 10 Stories of The Day!

14 Aug, 2018 | 01:03h | UTC

 

1 – Clinically applicable deep learning for diagnosis and referral in retinal disease – Nature Medicine (free for a limited period)

Commentaries: Opening the ‘black box,’ Google DeepMind AI system diagnoses eye diseases and shows its work – STAT (free) AND Artificial intelligence tool ‘as good as experts’ at detecting eye problems – The Guardian (free)

 

2 – Automated deep-neural-network surveillance of cranial images for acute neurologic events – Nature Medicine (free for a limited period)

Commentaries: Artificial Intelligence Platform Screens for Acute Neurological Illnesses at Mount Sinai – Mount Sinai Health System, via NewsWise (free) AND AI diagnoses neurological diseases on CT in 1.2 seconds – Health Imaging (free) AND New AI system can screen for neurological illnesses in seconds – UPI (free)

 

3 – Screening for Urinary Incontinence in Women: A Recommendation From the Women’s Preventive Services Initiative – Annals of Internal Medicine (free)

Commentaries: WPSI says screen all women annually for urinary incontinence – American College of Physicians, via EurekAlert (free)

 

4 – Diagnosis of Invasive Fungal Diseases in Haematology and Oncology. 2018 Update of the Recommendations of the Infectious Diseases Working Party of the German Society for Hematology and Medical Oncology (AGIHO) – Mycosis (free PDF)

 

5 – American Academy of Family Physicians: Twenty Things Physicians and Patients Should Question (free)

Commentary: Choosing Wisely: New Practices to Avoid in Family Medicine – NEJM Journal Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

6 – Analysis of clinical benefit, harms, and cost-effectiveness of screening women for abdominal aortic aneurysm – The Lancet (free)

Commentaries: Should we screen women for abdominal aortic aneurysm? – The Lancet (free) AND Cost-Effectiveness of Screening Women for AAA – American College of Cardiology (free) AND Women Likely Not Good Targets for AAA Screening, Study Suggests – TCTMD (free)

 

7 – Prevalence and Estimated Economic Burden of Substandard and Falsified Medicines in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: Prevalence of Substandard and Falsified Essential Medicines: Still an Incomplete Picture – JAMA Network Open (free) AND New Study Finds Fake, Low-Quality Medicines Prevalent in the Developing World – University of North Carolina at Chapel Hill, via R&D (free)

 

8 – Evaluating Shared Decision Making for Lung Cancer Screening – JAMA Internal Medicine (free for a limited period)

Editorial: Failing Grade for Shared Decision Making for Lung Cancer Screening (free for a limited period)

Author Interview: Evaluating Shared Decision Making for Lung Cancer Screening (free audio)

Commentaries: Doctors may not explain pros, cons of lung cancer screening – Reuters (free) AND Shared Decision-Making Flops for Lung Ca Screening – MedPage Today (free registration required)

 

9 – Perspective: Surrogate End Points Ain’t all that Bad – The Health Care Blog (free) (via @RogueRad)

 

10 – Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Early type 1 diabetes shortens women’s lives by 18 years – University of Gothenburg, via ScienceDaily (free) AND Early age type 1 diabetes linked to shorter life expectancy than later age diagnosis – OnMedica (free)

 


Mon, August 13 – 10 Stories of The Day!

13 Aug, 2018 | 00:05h | UTC

 

1 – Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)

 

2 – Outbreaks: Behind the headlines – World Health Organization (free)

 

3 – Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction – JAMA Network Open (free)

Commentaries: Algorithm IDs Patients at Risk of Post-MI Events – MedPage Today (free registration required) AND Risk Model Helps Predict CV Events 1 Year After Acute MI – Medscape (free registration required)

 

4 – Analysis: Renaming low risk conditions labelled as cancer – The BMJ (free for a limited period)

Commentaries: Is it time to remove the cancer label from low-risk conditions? – The Conversation (free) AND Doctors should avoid saying ‘cancer’ for minor lesions – study – The Guardian (free) Drop ‘cancer’ label to protect patients from over-treatment, researchers say – The Sidney Morning Herald (free)

 

5 – Review: Dos and Don’ts in the Management of Cirrhosis: A View from the 21st Century – American Journal of Gastroenterology (via @Abraham_RMI)

 

6 – The multivitamin industry rakes in billions of dollars. But science says we’re not getting healthier – by Timothy Caulfield, in NBC News THINK (free)

Related Study: Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free) AND Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)

“Unless you have a clinically identified deficiency, the research tells us there is little reason to consume supplements.”

 

7 – Tick- and Mosquito-Borne Diseases Are Increasing Dramatically – Scientific American (free)

Related: CDC Report: U.S Trends in Vector-borne Diseases (link to report and commentaries)

 

8 – Infographic: High burden, low budget: non-communicable diseases in low- and middle-income countries – Institute for Health Metrics and Evaluation (free) (via @equitylist)

 

9 – Multifactorial and multiple component interventions for preventing falls in older people living in the community – Cochrane Library (free)

Summary: Featured Review: Multifactorial and multiple component interventions for preventing falls in older people living in the community – Cochrane Library (free)

 

10 – Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016 – Kidney International (free)

News release and visual abstract: KI article shows the doubling incidence, prevalence and mortality of CKD – International Society of Nephrology (free)

Commentary: Global Burden of Kidney Disease on the Rise, Unequally Distributed – Medscape (free registration required)

 


Fri, August 10 – 10 Stories of The Day!

10 Aug, 2018 | 02:01h | UTC

 

1 – Dietary Diversity: Implications for Obesity Prevention in Adult Populations: A Science Advisory From the American Heart Association – Circulation (free PDF)

News Release: A diverse diet may not be the healthiest one (free)

Commentary: Diet Recommendations for Obesity Prevention: Time to Ditch Diversity (free)

Top Ten Things to Know: Dietary Diversity: Implications for Obesity Prevention in Adult Populations (free PDF)

 

2 – Opioid prescribing decreases after learning of a patient’s fatal overdose – Science (free for a limited period)

Commentary: Notification of patient overdose deaths reduces clinician opioid prescriptions – NIH News Releases (free) AND Clinicians were told their patient had died of an overdose. Then opioid prescribing dropped – STAT (free)

 

3 – Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis – The Lancet Psychiatry (free)

Commentaries: Refining treatment choices for ADHD – The Lancet Psychiatry (free) AND ADHD medications: Of all available drugs, methylphenidate should be first option for short-term treatment in children – ScienceDaily (free) AND Analysis of ADHD Drugs: Use Methylphenidate in Kids, Amphetamines in Adults – Physician’s First Watch (free)

Related: Cochrane Review: Adverse Events of Methylphenidate for ADHD in Children and Adolescents (link to abstract and free summary) AND Short Review: Stimulants for ADHD in children (free) AND Opinion: Drug treatment of ADHD – tenuous scientific basis (free)

 

4 – Viewpoint: Clinical Practice Guidelines: What’s Next? – JAMA (free for a limited period)

 

5 – Urinary sodium excretion, blood pressure, cardiovascular disease, and mortality: a community-level prospective epidemiological cohort study – The Lancet (link to abstract – $ for full-text)

Commentary: Lancet Paper Adds To Evidence That Reducing Salt To Very Low Levels May Be Dangerous – CardioBrief (free)

Related Report: Salt intake and Cardiovascular Disease (free report and commentaries)

 

6 – Are the “Best Buys” for Alcohol Control Still Valid? An Update on the Comparative Cost-Effectiveness of Alcohol Control Strategies at the Global Level – Journal of Studies on Alcohol and Drugs (free)

Commentary: Higher alcohol taxes are cost-effective in reducing alcohol harms – ScienceDaily (free)

Related: To improve global health, tax the things that are killing us – Financial Times (free policies, articles and commentaries) AND Policy lessons from health taxes (free research and commentaries)

 

7 – Nonsurgical Treatments for Urinary Incontinence in Women: A Systematic Review Update – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF)

 

8 – Scaled deployment of Wolbachia to protect the community from Aedes transmitted arboviruses – Gates Open Research (free)

Commentary: Dengue rates plummet in Australian city after release of modified mosquitoes – Nature News (free)

 

9 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: DRC probes more suspected Ebola cases, rules out 3 – CIDRAP (free) AND War zone complicates roll-out of Ebola vaccine in latest outbreak – Nature News (free)

 

10 – Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: How common is endometrial cancer in women with postmenopausal bleeding? – eCancer News (free) AND Postmenopausal Bleeding: Reliable Sign of Endometrial Cancer – Medscape (free registration required)

 


Mon, August 6 – 10 Stories of The Day!

6 Aug, 2018 | 00:05h | UTC

 

1 – Delirium in adult cancer patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

2 – Comparison of Clinical Outcomes Among Patients With Atrial Fibrillation or Atrial Flutter Stratified by CHA2DS2-VASc Score – JAMA Network Open (free)

Commentaries: Ischemic Stroke Risk Scoring May Not Be Accurate for Patients with Atrial Flutter – TCTMD (free) AND Don’t Group Afib, Atrial Flutter Together in Evaluating Stroke Risk – MedPage Today (free registration required)

 

3 – The Surviving Sepsis Campaign: A Rush to Judgment – NEJM Journal Watch (free)

Original Guideline: The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)

Related Opinion: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free)

 

4 – Playing Doctor with Watson: Medical Applications Expose Current Limits of AI – Spiegel (free) (via @EricTopol)

“IBM has big plans for how its Watson artificial intelligence software could change the medical industry. But a number of hospitals have ended their experiments with the platform, arguing that it doesn’t help diagnose or treat diseases.”

 

5 – Bias in medical research: A glossary of common research biases – First10Em (free) (via @pash22)

Related: Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

 

6 – The Illness Is Bad Enough. The Hospital May Be Even Worse – The New York Times (10 articles per month are free)

Related: Post-Hospital Syndrome — An Acquired, Transient Condition of Generalized Risk – New England Journal of Medicine (free) AND Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? – Journal of Hospital Medicine (free) (via @hmkyale)

“The elderly are particularly vulnerable to “post-hospital syndrome,” some experts believe, and that may be why so many patients return.”

 

7 – Quantifying excess deaths related to heatwaves under climate change scenarios: A multicountry time series modelling study – PLOS Medicine (free)

Commentaries: Heatwave deaths will rise steadily by 2080 as globe warms up – Monash University, via ScienceDaily (free) AND Heatwave deaths likely to rise steadily by 2080 without appropriate climate and health policies – London School of Hygiene & Tropical Medicine (free)

Related Lancet Editorial: Heatwaves and health (free)

Related Report: Lancet Countdown: Traking Progress on Health and Climate Change (free report, commentaries, infographics, video and other resources)

 

8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: Conflict in new Ebola zone of DR Congo exacerbates complexity of response: WHO emergency response chief – UN News (free) AND WHO: Ebola DRC outbreak taking place in ‘war zone’ – CIDRAP (free) AND Ebola In A Conflict Zone – NPR (free) AND WHO sees complex vaccine and security questions in Ebola response – Reuters (free)

 

9 – Colloids versus crystalloids for fluid resuscitation in critically ill people – Cochrane Library (link to abstract – $ for full-text)

Summary: Colloids or crystalloids for fluid replacement in critically people – Cochrane Library (free)

Using starches, dextrans, albumin or FFP (moderate-certainty evidence), or gelatins (low-certainty evidence), versus crystalloids probably makes little or no difference to mortality. Starches probably slightly increase the need for blood transfusion and RRT (moderate-certainty evidence), and albumin or FFP may make little or no difference to the need for renal replacement therapy (low-certainty evidence)”.

 

10 – Peer-supported self-management for people discharged from a mental health crisis team: a randomised controlled trial – The Lancet (free)

Commentaries: Peer-delivered self-management programmes in mental health – The Lancet (free) AND After the crisis: self-management and peer-support – The Mental Elf (free) AND Peer Support Helps Reduce Mental Crisis Readmissions – MedPage Today (free registration required)

 


Thu, August 9 – 10 Stories of The Day!

9 Aug, 2018 | 01:34h | UTC

 

1 – Practice guideline update recommendations summary: Disorders of consciousness – American Academy of Neurology (free PDF)

Related: Ethical, palliative, and policy considerations in disorders of consciousness – Neurology (free PDF) AND Comprehensive systematic review update summary: Disorders of consciousness – Neurology (free PDF)

Commentaries: New Guideline Released for Managing Vegetative and Minimally Conscious States – American Academy of Neurology, via NewsWise (free) AND Groups Issue New Disorders of Consciousness Guidelines – MedPage Today (free registration required)

 

2 – Labor Induction versus Expectant Management in Low-Risk Nulliparous Women – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Labor Induction versus Expectant Management in Low-Risk Women (free)

Commentaries: Induced labor at 39 weeks may reduce likelihood of C-section, NIH study suggests – NIH News Releases (free) AND Pregnancy Debate Revisited: To Induce Labor, Or Not? – NPR (free)

 

3 – Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth – New England Journal of Medicine (free)

Commentary: Maternal Vitamin D Supplementation Doesn’t Improve Infant Growth – Physician’s First Watch (free)

 

4 – Outcomes of Cardiac Screening in Adolescent Soccer Players – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Footballer heart death risk ‘underestimated’ – BBC (free) AND No Easy Answers on Best Heart Check-Up for Young Athletes – Associated Press, via NYT (free)

 

5 – Would technology enabled remote consulting save time and add value in primary care? – The BMJ Opinion (free)

“Would remote consulting save time and add value in primary care? Rising multimorbidity makes the evaluation of potentially time saving technologies ever more necessary” (via @bmj_latest see Tweet)

 

6 – Treatment for Bipolar Disorder in Adults: A Systematic Review – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF) AND Evidence Summary (free PDF)

 

7 – WHO MERS Global Summary and Assessment of Risk – World Health Organization (free PDF)

Commentary: WHO highlights ongoing hospital MERS outbreak threat – CIDRAP (free)

 

8 – Perspective: Addressing Barriers to Inclusion of Pregnant Women in Clinical Trials – JAMA (free for a limited period)

 

9 – Publication bias: The answer to your research question may be sitting in somebody’s file drawer – Students 4 Best Evidence (free)

Related: Bias in medical research: A glossary of common research biases – First10Em (free) Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

 

10 – Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Expert reaction to physical activity linked to improved mental health – Science Media Centre (free) AND Regular exercise ‘best for mental health’ – BBC (free) AND Exercise is good for your body and your mind, study says – CNN (free)

 


Wed, August 8 – 10 Stories of The Day!

8 Aug, 2018 | 02:21h | UTC

 

1 – Screening for Atrial Fibrillation With Electrocardiography: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Atrial Fibrillation Comes With Many Snags (free for a limited period) AND Electrocardiography Screening for Atrial Fibrillation: We Can Do Better (free for a limited period)

Author Interview: USPSTF Recommendation: Screening for Atrial Fibrillation With Electrocardiography (free audio)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for atrial fibrillation with ECG. (I statement)”

 

2 – Mortality effects of timing alternatives for hip fracture surgery – Canadian Medical Association Journal (free)

Commentaries: Lower death rate when senior hip fractures are repaired quickly – Reuters (free) AND Delayed surgery for hip fractures cause of preventable deaths, study finds – The Globe and Mail (free) AND The sun should not set twice before hip fracture repair – CMAJ, via ScienceDaily (free)

 

3 – Update: Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Men with Possible Zika Virus Exposure — United States, August 2018 – CDC, MMWR (free)

Related: Vital Signs: Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018 – CDC, MMWR (free)

Commentaries: 1 in 7 kids exposed to Zika in utero suffers defects, delays – CIDRAP (free) AND 1 in 7 babies exposed to Zika in the womb have health problems, CDC reports – STAT (free) AND One in 7 babies prenatally exposed to Zika has health problems, CDC says – CNN (free)

 

4 – Corticosteroid use and intensive care unit-acquired weakness: a systematic review and meta-analysis – Critical Care (free)

 

5 – The use of viscoelastic haemostatic assays in the management of major bleeding: A British Society for Haematology Guideline – British Journal of Haematology (free)

Source: Critical Care Reviews Newsletter

 

6 – Perspective: Workplace Wellness Programs Don’t Work Well. Why Some Studies Show Otherwise. – The New York Times (10 articles per month are free)

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: July 2018 – eCancer News (free)

 

8 – Cardiotoxicity and Cardiac Monitoring Among Chemotherapy-Treated Breast Cancer Patients – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentaries: Prioritize cardiac monitoring for high-risk breast cancer patients, study suggests – ACP Internist (free) AND Cardiac monitoring may benefit high-risk breast cancer patients against heart failure – Cardiovascular Business (free) AND After Cardiotoxic Chemo, Less Than Half of Women With Breast Cancer Get Recommended Monitoring – TCTMD (free) AND Study Shows Importance of Cardiac Monitoring in High-Risk Breast Cancer Patients – American College of Cardiology (free)

 

9 – Special Issue: Roles of Physicians in Healthy Dying- AMA Journal of Ethics (free articles)

“What the roles of clinicians and patients should be in defining what constitutes a quality dying experience and good care of dying people has received less attention than issues like euthanasia and assisted death. Which parts of dying, if any, should be medicalized and why? What do patients and clinicians need to know about dying and why? The August 2018 issue of the AMA Journal of Ethics explores these and other questions.”

 

10 – Twelve-Month Outcomes After Transplant of Hepatitis C–Infected Kidneys Into Uninfected Recipients: A Single-Group Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Patients who accepted infected kidneys cured of hepatitis C – STAT (free) AND Good Outcomes for HCV-Negative Recipients of HCV Kidneys – Renal & Urology News (free)

 


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