TOP 10 Medical News Stories


1 – Peripartum management of hypertension: a position paper of the ESC Council on Hypertension and the European Society of Hypertension – European Heart Journal – Cardiovascular Pharmacotherapy (free)


2 – AGA Clinical Practice Guidelines on the Management of Moderate to Severe Ulcerative Colitis – Gastroenterology (free PDF)

Related: British Society of Gastroenterology Guidelines on the Management of Inflammatory Bowel Disease (guidelines on the subject)


3 – Lack of new antibiotics threatens global efforts to contain drug-resistant infections – World Health Organization (free)

See Reports: Antibacterial agents in clinical development – an analysis of the antibacterial clinical development pipeline – World Health Organization (free PDF) AND Antibacterial agents in preclinical development – World Health Organization (free PDF)

Commentary: W.H.O. Warns That Pipeline for New Antibiotics Is Running Dry – The New York Times (10 articles per month are free)


4 – Effect of Vitamin C, Hydrocortisone, and Thiamine vs Hydrocortisone Alone on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock: The VITAMINS Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Lack of Benefit of High-Dose Vitamin C, Thiamine, and Hydrocortisone Combination for Patients With Sepsis (free)

Conference Presentation: Effect of Vitamin C and Thiamine on Time Alive and Free of Vasopressor Support Among Patients With Septic Shock (free)

Commentaries: JC: The Vitamins trial. Hydrocortisone, Vit C and Thiamine (Marik protocol – or not?) in sepsis – St Emlyn’s (free) AND Vitamin Treatment For Sepsis Fails In Large Trial – NPR (free) AND Metabolic Resuscitation: Was the answer inside us all along? – PulmCrit (free)


5 – Effect of Stress Ulcer Prophylaxis With Proton Pump Inhibitors vs Histamine-2 Receptor Blockers on In-Hospital Mortality Among ICU Patients Receiving Invasive Mechanical Ventilation: The PEPTIC Randomized Clinical Trial – JAMA (free)

Editorial: Proton Pump Inhibitors vs Histamine-2 Receptor Blockers for Stress Ulcer Prophylaxis in Critically Ill Patients: Issues of Interpretability in Pragmatic Trials (free for a limited period)

Conference Presentation: Effect of Stress Ulcer Prophylaxis With PPIs vs H2RBs on Mortality in Ventilated ICU Patients (free)

Commentaries: JC: The PEPTIC study PPI vs H2RBs on the ICU – St Emlyn’s (free) AND Risks And Benefits Of Proton Pump Inhibitors To Prevent Gi Bleeds In Intensive Care Patients – (free)


6 – A review of cancer immunotherapy toxicity – CA: A Cancer Journal for Clinicians (free)

Related: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)


7 – New Chinese virus ‘will have infected hundreds’ – BBC (free)

Original Analysis: Estimating the potential total number of novel Coronavirus cases in Wuhan City, China – Imperial College London (free)

See also: As Thailand notes 2nd nCoV case, CDC begins airport screening – CIDRAP (free) AND China reports new virus cases, raising concern globally before key holiday – Reuters (free) AND China to step up countermeasures as virus outbreak grows – Reuters (free) AND China Reports New Cases of Deadly Virus, Adding to Fears of Outbreak – The New York Times (10 articles per month are free)


8 – The EVALI and Youth Vaping Epidemics — Implications for Public Health – New England Journal of Medicine (free)

See also: Update: Product, Substance-Use, and Demographic Characteristics of Hospitalized Patients in a Nationwide Outbreak of E-cigarette, or Vaping, Product Use–Associated Lung Injury — United States, August 2019–January 2020 – Centers for Disease Control and Prevention (free)

Related: CDC: Vaping Lung Illness Probably Caused by Vitamin E Acetate (free resources)


9 – 3-month versus 6-month adjuvant chemotherapy for patients with high-risk stage II and III colorectal cancer: 3-year follow-up of the SCOT non-inferiority RCT – Health Technology Assessment (free)

Original Article: 3 versus 6 months of adjuvant oxaliplatin-fluoropyrimidine combination therapy for colorectal cancer (SCOT): an international, randomised, phase 3, non-inferiority trial – The Lancet Oncology (free)

Source: EvidenceAlerts


10 – Femtosecond laser-assisted versus phacoemulsification cataract surgery (FEMCAT): a multicentre participant-masked randomised superiority and cost-effectiveness trial – The Lancet (link to abstract – $ for full-text)



1 – Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study – The Lancet (free)

Commentaries: A global accounting of sepsis – The Lancet (free) AND Sepsis associated with 1 in 5 deaths globally, double previous estimate – Institute for Health Metrics and Evaluation (free)


2 – Spanish Guidelines for Diagnosis, Management, Treatment and Prevention of DRESS syndrome – Journal of Investigational Allergology and Clinical Immunology (free PDF)


3 – Guideline: Indoor air quality at home – National Institute for Health and Care Excellence (free)


4 – Trial of Anifrolumab in Active Systemic Lupus Erythematosus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: TULIP2 – Anifrolumab Succeeds in Lupus – RheumNow (free)


5 – Invalidity of an Oft-Cited Estimate of the Relative Harms of Electronic Cigarettes – American Journal of Public Health (free)

Commentary: Frequently cited claim that e-cigarettes are ‘95% safer’ is misleading and outdated – Virginia Commonwealth University (free)


6 – Critical care management of infectious meningitis and encephalitis – Intensive Care Medicine (free)


7 – Global reach of ageism on older persons’ health: A systematic review – PLOS One (free)

Commentary: Harmful effects of ageism on older persons’ health found in 45 countries – Yale University (free)


8 – The effectiveness of influenza vaccination in pregnancy in relation to child health outcomes: Systematic review and meta-analysis – Vaccine (free)


9 – Atrial Failure as a Clinical Entity: JACC Review Topic of the Week – Journal of the American College of Cardiology (free)


10 – Association of Baseline Prostate-Specific Antigen Level With Long-term Diagnosis of Clinically Significant Prostate Cancer Among Patients Aged 55 to 60 Years: A Secondary Analysis of a Cohort in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial – JAMA Network Open (free)

Commentary: PSA repeat screening strategy should be tailored to baseline PSA – MedwireNews (free)



1 – Four major results to be presented at #CCR20 – PEPTIC, 65, & VITAMINS trials, plus the IHME Sepsis Study – More Info on the Critical Care Reviews Website

Commentary: Clinical trial results in critical care medicine to be unveiled at leading UK conference – EurekAlert (free)


– Thursday January 16th (09:00 to 10:30) – 65 Results Presentation Session –

See Study Protocol: Evaluating the clinical and cost-effectiveness of permissive hypotension in critically ill patients aged 65 years or over with vasodilatory hypotension: Protocol for the 65 randomised clinical trial – Journal of the Intensive Care Society (free)


– Thursday January 16th (16:35 to 17:40 – IHME Sepsis Study Results –


– Friday January 17th (09:00 to 10:30) – PEPTIC Trial Results Session –

See Study Protocol: A cluster randomised, crossover, registry-embedded clinical trial of proton pump inhibitors versus histamine-2 receptor blockers for ulcer prophylaxis therapy in the intensive care unit (PEPTIC study): study protocol. – Critical Care and Resuscitation (free PDF)


– Friday January 17th (11:00 to 12:30) – VITAMINS Trial Results –

See Study Protocol: Vitamin C, Hydrocortisone and Thiamine in Patients with Septic Shock (VITAMINS) trial: study protocol and statistical analysis plan – Critical Care and Resuscitation (free PDF)


2 – Report Summary: What researchers think about the culture they work in – Wellcome Trust (free)

Full Report: What researchers think about the culture they work in – Wellcome Trust (free PDF)

Commentary: Researchers facing ‘shocking’ levels of stress, survey reveals – The Guardian (free)


3 – A Randomized Trial of Erythropoietin for Neuroprotection in Preterm Infants – New England Journal of Medicine (link to abstract – $ for full-text)


4 – Effect of a Behavioral Intervention to Increase Vegetable Consumption on Cancer Progression Among Men With Early-Stage Prostate Cancer: The MEAL Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: Eating more vegetables provides no extra protection for men with prostate cancer – News Medical (free) AND Does Increased Vegetable Consumption Affect Prostate Cancer Progression? – (free)


5 – Patient-Reported Outcomes Through 5 Years for Active Surveillance, Surgery, Brachytherapy, or External Beam Radiation With or Without Androgen Deprivation Therapy for Localized Prostate Cancer – JAMA (free for a limited period)

Related Study: Ten-year Outcomes in Men with Localized Prostate Cancer from the ProtecT Randomized Controlled Trial According to Treatment Received (free)

Commentaries: Prostatectomy-associated urinary incontinence disparities persist at 5 years – MedwireNews (free) AND Prostate Cancer Treatment Side Effects Worse With Prostatectomy – Renals & Urology News (free)


6 – Interventions and Operations 5 Years After Bariatric Surgery in a Cohort From the US National Patient-Centered Clinical Research Network Bariatric Study – JAMA Surgery (free)

Author Interview: Interventions and Operations 5 Years After Bariatric Surgery (free)

Commentaries: Bariatric Surgery Is Safe and It Works – JAMA Surgery (free for a limited period) AND Procedures And Hospitalizations Common After Bariatric Procedures – (free) AND More Interventions Follow Gastric Bypass than Gastric Sleeve, Large Study Shows – Health Sciences at the University of Pittsburgh (free)

Related Study: Cohort Study: Risk of Operative and Nonoperative Interventions After Roux-en-Y Gastric Bypass vs. Vertical Sleeve Gastrectomy (free)


7 – An integrated perfusion machine preserves injured human livers for 1 week – Nature Biotechnology (free for a limited period)

Commentaries: Machine keeps human livers alive for one week outside of the body – University of Zurich (free) AND Machine Could Expand Pool of Livers for Donation – HealthDay News (free)


8 – A network meta‐analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression – World Psychiatry (free)


9 – Management of patients undergoing same-day discharge primary total hip and knee arthroplasty – Canadian Medical Association Journal (free)

Related: Consensus statement for perioperative care in total hip replacement and total knee replacement surgery: Enhanced Recovery After Surgery (ERAS®) Society recommendations – Acta Orthopaedica (free)


10 – The Development of a Standardized Pathway for Outpatient Ambulatory Fracture Surgery – The Journal of Bone and Joint Surgery (free)

Commentary: Strong Case for Outpatient Fracture Surgery – Orthobuzz (free)



1 – News Release: American College of Radiology Releases New and Updated ACR Appropriateness Criteria (free)

See also: Complete list of ACR Appropriateness Criteria topics and ratings tables (free)


2 – Clostridioides difficile (formerly Clostridium difficile) infection in the critically ill: an expert statement – Intensive Care Medicine (free for a limited period)

Related: Clostridioides Difficile: Diagnosis and Treatments (free BMJ review and guidelines on the subject)


3 – European Respiratory Society guideline on long-term management of children with bronchopulmonary dysplasia – European Respiratory Journal (free)


4 – Effectiveness of Combined Behavioral and Drug Therapy for Overactive Bladder Symptoms in Men: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentaries: What Works Best to Help Men With Overactive Bladder? – HealthDay News (free) AND For Overactive Bladder in Men, Start with Behavioral Strategies – NEJM Journal Watch (free)


5 – Physician Time Spent Using the Electronic Health Record During Outpatient Encounters: A Descriptive Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Doctors average 16 minutes on the computer for every patient – Reuters (free) AND How Doctors May Be Spending More Time With Electronic Health Records Than Patients – Forbes (free)

Related: Opinion – “The EMR has changed the doctor-patient duet into a ménage-à-trois” (free resources on the subject)


6 – Safety clinical trial shows possible increased risk of cancer with weight-loss medicine Belviq, Belviq XR (lorcaserin) – U.S. Food & Drug Administration (free)

Commentaries: CV Safety Trial for Lorcaserin Picks Up Cancer Signal: FDA – TCTMD (free) AND FDA Warning: Weight Loss Drug Belviq May Increase Cancer Risk- Forbes (free)


7 – Changes in Quality of Care after Hospital Mergers and Acquisitions – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Hospital mergers don’t improve readmissions, mortality or experience, study – Modern Healthcare (free) AND Patient satisfaction may decline after hospital acquisition – Reuters (free)


8 – The Effect of Coconut Oil Consumption on Cardiovascular Risk Factors: A Systematic Review and Meta-Analysis of Clinical Trials – Circulation (free PDF for a limited period)


9 – Enhanced Recovery After Surgery (ERAS) Reduces Hospital Costs and Improve Clinical Outcomes in Liver Surgery: a Systematic Review and Meta-Analysis – Journal of Gastrointestinal Surgery (free)

Related: Guidelines for Perioperative Care for Liver Surgery: Enhanced Recovery After Surgery (ERAS) Society Recommendations – World Journal of Surgery (free)

Related: Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines (free articles)


10 – The application of enhanced recovery after surgery for upper gastrointestinal surgery: Meta-analysis – BMC Surgery (free)

Related: Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines (free articles)



1 – Urgent health challenges for the next decade – World Health Organization (free)

Commentary: ‘No shortcuts to a healthier world’: WHO chief sets out health priorities for the decade – UN News (free)


2 – Homepage: Achieving fair pricing of medicines – The BMJ (free articles)

Editorial: Can affordability and innovation coexist for medicines?

– Defining the concept of fair pricing for medicines

– Strategies to achieve fairer prices for generic and biosimilar medicines

– Pricing of pharmaceuticals is becoming a major challenge for health systems

– New business models for research and development with affordability requirements are needed to achieve fair pricing of medicines

– Price transparency is a step towards sustainable access in middle income countries


3 – Benefits of short-term or prolonged as compared to standard 1 year DAPT in patients with acute coronary syndrome treated with drug-eluting stents: a meta-analysis of 9 randomized trials – Journal of Thrombosis and Thrombolysis (free)


4 – New possibilities on transplanting kidneys from hepatitis C virus positive donors: a Systematic Review – Transplantation Reviews (free)

Related: Favorable 1-Year Outcomes with Transplantation of HCV-Viremic Kidneys (studies and commentaries on the subject)


5 – You Are Unvaccinated and Got Sick. These Are Your Odds. – The New York Times (10 articles per month are free)

Comparing the dangerous effects of three diseases with the minimal side effects of their corresponding vaccines.”


6 – New baby: fads, fashions and evidence for new parents – Evidently Cochrane (free)


7 – Work Up of Fatty Liver by Primary Care Physicians, Review – Annals of Medicine and Surgery (free)


8 – Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial – JAMA Psychiatry (free)

Editorial: The Potential Role of Lumateperone—Something Borrowed? Something New? – JAMA Psychiatry (free for a limited period)


9 – Association of Ticagrelor vs Clopidogrel With Major Adverse Coronary Events in Patients With Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention – JAMA Internal Medicine (free for a limited period)

Commentary: Brilinta Questioned for Acute Coronary Syndrome – MedPage Today (free registration required)


10 – Important Food Sources of Fructose‐Containing Sugars and Incident Hypertension: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies – Journal of the American Heart Association (free)

Commentary: Does sugar raise blood pressure? It depends where it comes from, researchers say – University of Toronto (free)



1 – ACC/AHA/ASE/HRS/ISACHD/SCAI/SCCT/SCMR/SOPE 2020 Appropriate Use Criteria for Multimodality Imaging During the Follow-Up Care of Patients With Congenital Heart Disease – Journal of the American College of Cardiology (free)

Commentaries: Appropriate Use Criteria for Imaging of Congenital Heart Disease Patients: Key Points – American College of Cardiology (free) AND New AUC for Cardiac Imaging Follow-up in Congenital Heart Disease – TCTMD (free)


2 – Association of Deceased Donor Acute Kidney Injury With Recipient Graft Survival – JAMA Network Open (free)

Commentaries: Less-than-perfect kidneys can be successfully used for transplants, study shows – Johns Hopkins Medicine (free) AND Less than perfect kidneys safe for transplant, study shows – UPI (free) AND Greater Use of Deceased Donor AKI Kidneys Urged – Renal & Urology News (free)


3 – Adverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials – The Lancet Infectious Diseases (free registration required)

Commentaries: What is the best regimen to treat latent tuberculosis infection? – The Lancet Infectious Diseases (free) AND Four Months of Rifampicin May Be Best Option for Latent TB – Medscape / Reuters (free registration required)


4 – Homepage: Palliative Care – Medicine (free articles)

– Palliative care: introduction

– Pain control in palliative care

– Interventional management of pain in cancer and palliative care

– Nausea and vomiting in palliative care

– Constipation and malignant bowel obstruction in palliative care

– Breathlessness in advanced disease

– Psychiatric conditions in palliative medicine

– Emergencies in palliative care

– Palliative care in non-malignant disease

– Management of less common symptoms in palliative care

– Complications of systemic anti-cancer treatment

– Care in the last hours and days of life

– Advance care-planning and clinical decision-making

– Ethical principles in end-of-life care


5 – Homepage: Uncommon Severe Infections in the Intensive Care Unit – Clinical Microbiology and Infection (free articles)

– Improving care for the ICU patient with suspected infection: a multidisciplinary perspective

– Necrotizing skin and soft-tissue infections in the intensive care unit

– Management of infected pancreatic necrosis in the intensive care unit: a narrative review

– Mediastinitis in the intensive care unit patient: a narrative review

– When not to start antibiotics: avoiding antibiotic overuse in the intensive care unit


6 – Uterine Balloon Tamponade for the Treatment of Postpartum Hemorrhage: a Systematic Review and Meta-Analysis – American Journal of Obstetrics & Gynecology (link to abstract – $ for full-text)

Commentaries: Technique is almost 86 percent effective in preventing maternal death from hemorrhaging – Massachusetts General Hospital (free) AND Uterine Balloon Tamponade for Postpartum Bleeding Seems Safe – Physician’s Briefing (free)


7 – Different strategies for pharmacological thromboprophylaxis for lower-limb immobilisation after injury: systematic review and economic evaluation – Health Technology Assessment (free)

Source: EvidenceAlerts


8 – How I set up positive end-expiratory pressure: evidence- and physiology-based! – Critical Care (free)


9 – Mechanical ventilation in patients with acute ischaemic stroke: from pathophysiology to clinical practice – Critical Care (free)


10 – Tea consumption and the risk of atherosclerotic cardiovascular disease and all-cause mortality: The China-PAR project – European Journal of Preventive Cardiology (free for a limited period)

Commentaries: Tea drinkers live longer – European Society of Cardiology (free) AND Habitual Green Tea Drinkers May Live Longer – (free) AND Expert reaction to study looking at tea drinking, and health and longevity – Science Media Centre (free)



1 – Clinical Practice Guideline: Nosebleed (Epistaxis) – Otolaryngology–Head and Neck Surgery (free)

Executive Summary: Clinical Practice Guideline: Nosebleed (Epistaxis) – Otolaryngology–Head and Neck Surgery (free)

News Release: Nosebleed (epistaxis): New clinical practice guideline – American Academy of Otolaryngology-Head and Neck Surgery (free)


2 – Critical Update on the Third Edition of the Guidelines for Managing Severe Traumatic Brain Injury in Children – American Journal of Critical Care (free)

Original Article: New Guidelines for the Management of Pediatric Severe Traumatic Brain Injury (free guideline and news release)


3 – Recognition and Initial Management of Fulminant Myocarditis: A Scientific Statement from the American Heart Association – Circulation (free PDF)

News Release: Fast action and the right resources are key to treating fulminant myocarditis – American Heart Association (free)


4 – Blood Pressure Measurement: A KDOQI Perspective – American Journal of Kidney Diseases (free)


5 – Outcomes Six-Months After 100% or 70% of Enteral Calorie Requirements During Critical Illness (TARGET): A Randomized Controlled Trial – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Original Study: Energy-Dense versus Routine Enteral Nutrition in the Critically Ill (free study and commentary)

Source: Grupo UTIclínica – HCFMUSP


6 – Findings on education, malnutrition ‘deeply disturbing’ with United Nations’ goals 10 years away – Institute for Health Metrics and Evaluation (free)

See articles: Mapping child growth failure across low- and middle-income countries – Nature (free) AND Mapping disparities in education across low- and middle-income countries – Nature (free)


7 – Morbidity and mortality from road injuries: results from the Global Burden of Disease Study 2017 – Injury Prevention (free)

News Release: Probability of dying from road injury has dropped worldwide in all but 5 nations – Institute for Health Metrics and Evaluation (free)


8 – Healthy lifestyle and life expectancy free of cancer, cardiovascular disease, and type 2 diabetes: prospective cohort study – The BMJ (free)

Commentaries: Healthy habits add up to 10 disease-free years to your life, study reveals – NHS Choices (free) AND 5 healthful living factors extend disease-free life – Medical News Today (free) AND Healthy habits ‘deliver extra disease-free decade’ – BBC (free)


9 – Appropriate use Criteria – American Academy of Orthopaedic Surgeons (free)

Commentary: AAOS releases guidelines, appropriate use criteria for care of trauma patients – Healio (free registration required)


10 – Cognition After Early Tonsillectomy for Mild OSA – Pediatrics (link to abstract – $ for full-text)

Commentary: Tonsillectomy doesn’t boost cognitive skills for preschoolers with mild apnea – Reuters (free)



1 – Perforated and bleeding peptic ulcer: WSES guidelines – World Society of Emergency Surgery (free)


2 – 2019 American College of Rheumatology/Arthritis Foundation Guideline for the Management of Osteoarthritis of the Hand, Hip, and Knee – Arthritis & Rheumatology (free)

News Release: ACR and Arthritis foundation release updated treatment guideline for OA – American College of Rheumatology (free)


3 – American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis – Gastroenterology (free)

Related Reviews: Step-up approach for the management of pancreatic necrosis: a review of the literature – Trauma Surgery & Acute Care Open (free) AND Management of severe acute pancreatitis – The BMJ (free for a limited period)

Related Guidelines: 2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery (free) AND American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis (free) AND Pancreatitis – National Institute for Health and Care Excellence (free) AND American College of Gastroenterology Guideline: Management of Acute Pancreatitis (free)


4 – Practices to Foster Physician Presence and Connection With Patients in the Clinical Encounter – JAMA (free for a limited period)

Editorials: Can an Evidence-Based Approach Improve the Patient-Physician Relationship? (free for a limited period) AND Connecting With Patients—The Missing Links (free for a limited period)

Author Interview: Practices to Foster Physician Presence and Connection with Patients in the Clinical Encounter (free)

Video: Connecting With Patients in Medicine (free)


5 – Health Care Hotspotting — A Randomized, Controlled Trial – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Reduce Health Costs By Nurturing The Sickest? A Much-Touted Idea Disappoints – Kaiser Health News (free) AND Did a high-profile program really slash hospital spending? Or was it a cautionary tale of ‘regression to the mean’? – STAT (free)


6 – Alex Nowbar’s weekly review, 8 January 2020 – The BMJ Opinion (free)


7 – Effectiveness of Virtual vs In-Person Inhaler Education for Hospitalized Patients With Obstructive Lung Disease: A Randomized Clinical Trial – JAMA Network Open (free)

Commentary: Virtual instruction for inhaler technique nearly as effective as in-person instruction, study finds – ACP Hospitalist (free)


8 – Beyond depression: Other uses for tricyclic antidepressants – Cleveland Clinic Journal of Medicine (free)


9 – Public-access defibrillation and neurological outcomes in patients with out-of-hospital cardiac arrest in Japan: a population-based cohort study – The Lancet (link to abstract – $ for full-text)

Related: The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (free) AND Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (free) AND Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests – Circulation (free)


10 – Expanding Heart Transplant in the Era of Direct-Acting Antiviral Therapy for Hepatitis C – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: Hepatitis C-positive donors a viable option to expand heart donor pool – Vanderbilt University Medical Center (free) AND Expanding heart transplant in the era of direct-acting antiviral therapy for hepatitis C – 2 Minute Medicine (free)

Related Studies: Transplant of Hepatitis C–Infected Kidneys Into Uninfected Recipients (link to abstract and commentaries) AND Heart and Lung Transplants from HCV-Infected Donors to Uninfected Recipients (link to abstract and commentaries) AND Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus–Infected Donors to Noninfected Recipients (link to abstract and commentaries) AND Favorable 1-Year Outcomes with Transplantation of HCV-Viremic Kidneys (link to abstract and commentaries)



1 – Testosterone Treatment in Adult Men With Age-Related Low Testosterone: A Clinical Guideline From the American College of Physicians – Annals of Internal Medicine (free)

Commentaries: ACP issues guideline on testosterone treatment for age-related low testosterone levels – ACP Internist (free) AND Most older men don’t need testosterone replacement, new guidelines say – Reuters (free)


2 – Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine – Intensive Care Medicine (free)

Editorial: Transfusion thresholds: the dangers of guidelines based on randomized controlled trials (free)


3 – ACG Clinical Guideline: Disorders of the Hepatic and Mesenteric Circulation – American College of Gastroenterology (free)


4 – Collection Homepage: The Year in Cardiology 2019 – European Heart Journal (free articles)

– The Year in Cardiology: Acute Coronary Syndromes

– The Year in Cardiology: Aorta and Peripheral Circulation

– The Year in Cardiology: Arrhythmias and Pacing

– The Year in Cardiology: Imaging

– The Year in Cardiology: Cardiovascular Prevention

– The Year in Cardiology: Interventional Cardiology

– The Year in Cardiology: Valvular Heart Disease

– The Year in Cardiology: Heart Failure


5 – The Decade’s Top 10 Biggest Changes to ID Clinical Practice – HIV and ID Observations (free)


6 – Prevalence of Potentially Unnecessary Bimanual Pelvic Examinations and Papanicolaou Tests Among Adolescent Girls and Young Women Aged 15-20 Years in the United States – JAMA Internal Medicine (free for a limited period)

Commentaries: Unnecessary Bimanual Pelvic Examinations and Papanicolaou Testing in Adolescents and Young Women—Learning How to Unlearn – JAMA Internal Medicine (free for a limited period) AND Young women still may be getting unnecessary pelvic exams – University of California – San Francisco (free) AND Many young women get unnecessary pelvic exams – Reuters (free)


7 – Randomized clinical trial analyzing maintenance of peripheral venous catheters in an internal medicine unit: Heparin vs. saline – PLOS One (free)

Related Systematic Reviews: Heparin versus 0.9% sodium chloride locking for prevention of occlusion in central venous catheters in adults – Cochrane Library (free) AND Heparin flush vs. normal saline flush to maintain the patency of central venous catheter among adult patients: A systematic review and meta-analysis – Journal of Family Medicine and Primary Care (free)


8 – Neurodevelopmental Abnormalities in Children With In Utero Zika Virus Exposure Without Congenital Zika Syndrome – JAMA Pediatrics (free for a limited period)

Editorial: Neurodevelopmental Abnormalities Associated With In Utero Zika Virus Infection in Infants and Children—The Unfolding Story (free for a limited period)

Commentaries: Study underscores the importance of long-term follow-up for Zika-exposed infants – Children’s National Hospital (free) AND New study shows Zika’s long arm in children – CIDRAP (free) AND Healthy babies exposed to Zika in the womb may suffer developmental delays – ScienceNews (free)

Related: Study: Nearly A Third of Children Exposed to Zika In-utero Develop Neurological Problems by Age 3 (link to abstract and commentary) AND Study: Neurodevelopment in Infants Exposed to Zika Virus In Utero (free study and commentaries)


9 – Thyroid nodules: diagnostic evaluation based on thyroid cancer risk assessment – The BMJ (free for a limited period)


10 – Efficacy and Safety of Switching to Dolutegravir/Lamivudine Fixed-Dose Two-Drug Regimen Versus Continuing a Tenofovir Alafenamide–Based Three- or Four-Drug Regimen for Maintenance of Virologic Suppression in Adults With HIV-1: Phase 3, Randomized, Non-inferiority TANGO Study – Clinical Infectious Diseases (free PDF)



1 – Gastrointestinal bleeding prophylaxis for critically ill patients: a clinical practice guideline – The BMJ (free)

See also: Efficacy and safety of gastrointestinal bleeding prophylaxis in critically ill patients: systematic review and network meta-analysis – The BMJ (free)


2 – European Society of Endocrinology Clinical Practice Guideline: Endocrine work-up in obesity – European Journal of Endocrinology (free)


3 – Homepage: Special Issue: Advances in Perioperative Care – BJS / Anaesthesia (free articles)

– Perioperative care and collaboration between surgeons and anaesthetists – it’s about time

– Role of the anaesthetist in postoperative care

– Framework for prehabilitation services

– Role of critical care in improving outcomes for high‐risk surgical patients

– Scoping review of mode of anaesthesia in emergency surgery

– Strategies to minimize intraoperative blood loss during major surgery

– Perioperative care of the obese patient

– Rational performance metrics for operating theatres, principles of efficiency, and how to achieve it

– Acute postoperative pain management

– Meta‐analysis of preoperative high‐sensitivity cardiac troponin measurement in non‐cardiac surgical patients at risk of cardiovascular complications

– Network meta‐analysis of urinary retention and mortality after Lichtenstein repair of inguinal hernia under local, regional or general anaesthesia

– Meta‐analysis of α‐blockade versus no blockade before adrenalectomy for phaeochromocytoma

– Network meta‐analysis of local and regional analgesia following colorectal resection

– Randomized clinical trial of intraoperative dexmedetomidine to prevent delirium in the elderly undergoing major non‐cardiac surgery

– Randomized clinical trial of continuous transversus abdominis plane block, epidural or patient‐controlled analgesia for patients undergoing laparoscopic colorectal cancer surgery

– Qualitative study of clinician and patient perspectives on the mode of anaesthesia for emergency surgery

– Variation in global uptake of the Surgical Safety Checklist

– Safety and efficacy of non‐steroidal anti‐inflammatory drugs to reduce ileus after colorectal surgery

– International multicentre review of perioperative management and outcome for catecholamine‐producing tumours


4 – National, regional, and global burdens of disease from 2000 to 2016 attributable to alcohol use: a comparative risk assessment study – The Lancet Public Health (free)

Commentary: The burden of alcohol use: better data and strong policies towards a sustainable development – The Lancet Public Health (free)

Related: Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries) AND Alcohol Use and Burden for 195 Countries and Territories – The Lancet (free study and commentaries) AND Prioritising action on alcohol for health and development – The BMJ (free)


5 – Critical Care Management of Toxicities Associated With Targeted Agents and Immunotherapies for Cancer – Critical Care Medicine (free)

Related: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)


6 – Artificial Intelligence Is Rushing Into Patient Care – And Could Raise Risks – Scientific American (a few articles per month are free)

“AI systems are not as rigorously tested as other medical devices, and have already made serious mistakes.”


7 – Diagnosis and treatment of autoimmune hemolytic anemia in adults: Recommendations from the First International Consensus Meeting – Blood Reviews (free)

Related: Autoimmune hemolytic anemia – Hematology (free) AND Guidelines on the management of drug‐induced immune and secondary autoimmune, haemolytic anaemia – British Journal of Haematology (free)


8 – Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study – Gut (free)

Related Articles: Faecal microbiota transplantation versus placebo for moderate-to-severe irritable bowel syndrome: a double-blind, randomised, placebo-controlled, parallel-group, single-centre trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text) AND The effect of fecal microbiota transplantation on IBS related quality of life and fatigue in moderate to severe non-constipated irritable bowel: Secondary endpoints of a double blind, randomized, placebo-controlled trial – EbioMedicine (free)


9 – Efficacy and Safety of Early vs Elective Colonoscopy for Acute Lower Gastrointestinal Bleeding – Gastroenterology (free)

Commentary: Colonoscopy for Lower Gastrointestinal Bleeding—Time Is Not of the Essence – Gastroenterology (free)


10 – Early Colonoscopy Does Not Improve Outcomes of Patients With Lower Gastrointestinal Bleeding: Systematic Review of Randomized Trials – Clinical Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Early colonoscopy did not improve outcomes in those hospitalized for lower GI bleeding – ACP Gastroenterology (free)


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