TOP 10 Medical News Stories

 

1 – The 2019 report of The Lancet Countdown on health and climate change: ensuring that the health of a child born today is not defined by a changing climate – The Lancet (free registration required)

Editorial: Health and climate change: making the link matter (free)

Video: The Lancet Countdown on Health and Climate Change: 2019 report (free)

Commentaries: How the Climate Crisis Is Killing Us, in 9 Alarming Charts – Wired (free) AND Climate Change Poses Threats to Children’s Health Worldwide – The New York Times (10 articles per month are free) AND The climate crisis will profoundly affect the health of every child alive today, report says – CNN (free) AND Doctors: Warmer world is unhealthier place for children – AP (free)

Related: Climate Change — A Health Emergency (free reports and commentaries on the subject) AND NEJM Editorial: Prioritizing Health in a Changing Climate (free commentaries) AND Climate change threatens the achievement of effective universal healthcare – The BMJ (free) AND Climate Change Is Having a Major Impact on Global Health – Scientific American (free)

 

2 – Vegetarian diets in childhood and adolescence – Molecular and Cellular Pediatrics (free)

 

3 – International Society of Cardiovascular Infectious Diseases Guidelines for the Diagnosis, Treatment and Prevention of Disseminated Mycobacterium chimaera Infection Following Cardiac Surgery with Cardiopulmonary Bypass – Journal of Hospital Infection (free)

 

4 – Comparative efficacy and safety of new surgical treatments for benign prostatic hyperplasia: systematic review and network meta-analysis – The BMJ (free)

 

5 – Outcomes at follow-up of negative colonoscopy in average risk population: systematic review and meta-analysis – The BMJ (free)

Related Guidelines: ACP Guideline: Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults (free) AND BMJ Guideline: Colorectal Cancer Screening with Fecal Immunochemical Testing, Sigmoidoscopy or Colonoscopy (new guideline suggesting a more selective approach to screening) AND Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society (recent guideline with recommendation to start screening at 45 years, with links to guidelines from other organizations)

“Our findings suggest that 10 year intervals for colonoscopy screening after a negative colonoscopy, as currently recommended, may be adequate”

 

6 – A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research – European Journal of Epidemiology (free)

 

7 – Post-operative abdominal infections: epidemiology, operational definitions, and outcomes – Intensive Care Medicine (free)

Related Guidelines: The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines – World Journal of Emergency Surgery (free) AND Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference – World Journal of Emergency Surgery (free) AND The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections (free) AND The 2018 Lebanese Society of Infectious Diseases and Clinical Microbiology Guidelines for the use of antimicrobial therapy in complicated intra-abdominal infections in the era of antimicrobial resistance – BMC Infectious Diseases (free)

 

8 – Alex Nowbar’s weekly review, 15 November 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 

9 – Association of Subclinical Hearing Loss With Cognitive Performance – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)

Commentaries: Reconsidering Individuals with Normal Hearing – JAMA Otolaryngology-Head & Neck Surgery (free) AND Hearing loss, even when mild, linked to mental decline in seniors – Reuters (free) AND Earliest stage of hearing loss is linked to cognitive decline – Columbia University (free)

Author Interview: Association of Subclinical Hearing Loss With Cognitive Performance (free audio)

Related: Association of Hearing Loss With Dementia – JAMA Network Open (free) AND Meta-Analysis: Association of Age-Related Hearing Loss With Cognitive Function – JAMA Otolaryngology-Head & Neck Surgery (free)

 

10 – Illiteracy, dementia risk, and cognitive trajectories among older adults with low education – Neurology (link to abstract – $ for full-text)

News Release: People who cannot read may be three times as likely to develop dementia – American Academy of Neurology (free)

“The independent effect of illiteracy on dementia risk may be through a lower range of cognitive function, which is closer to diagnostic thresholds for dementia than the range of literate participants.”

 


 

1 – Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: What Can We Learn From The Apple Heart Study? – Cardiobrief (free)

“…nearly half a million people were required to identify a few hundred people with AF. (It should further be noted that we have no idea whether the patients identified in this group will even benefit from their diagnosis, since they may differ in important ways from AF patients identified by traditional means.)” (from Cardiobrief)

 

2 – Secondary Surgical Cytoreduction for Recurrent Ovarian Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Secondary surgery does not improve overall survival for recurrent ovarian cancer patients – University of Texas M. D. Anderson Cancer Center (free) AND Second surgery for many ovarian cancers found ineffective – Reuters (free)

 

3 – Guideline for Antibacterial Prophylaxis Administration in Pediatric Cancer and Hematopoietic Stem Cell Transplantation – Clinical Infectious Diseases (free PDF)

 

4 – Clinical practice guideline for the management of blood borne viruses within the haemodialysis unit – BMC Nephrology (free)

 

5 – Guideline on the use of iodinated contrast media in patients with kidney disease 2018 – Clinical and Experimental Nephrology (free)

 

6 – CDC Antibiotic Resistance Threats in the United States 2019 – Centers for Disease Control and Prevention (free PDF)

Commentaries: CDC spotlights ‘deadly threat’ of antibiotic resistance – CIDRAP (free) AND CDC report: 35,000 Americans die of antibiotic-resistant infections each year – STAT (free)

 

7 – Antibiotic Treatment and Appendectomy for Uncomplicated Acute Appendicitis in Adults and Children: A Systematic Review and Meta-analysis – Annals of Surgery (link to abstract – $ for full-text)

Related Meta-Analysis: Antibiotic therapy for acute uncomplicated appendicitis: a systematic review and meta-analysis – International Journal of Colorectal Disease (free) AND Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis (link to abstract and commentaries) AND Antibiotic Therapy versus Appendectomy for Acute Uncomplicated Appendicitis (free study and commentaries)

Related Randomized Trials: Antibiotic Therapy Alone Seems Reasonable for Uncomplicated Appendicitis (free study and commentaries) AND Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis (link to abstract and commentaries)

Related Cohort Study: Study: Nonoperative Management of Uncomplicated Appendicitis (free study and commentary)

 

8 – Adjunctive Antithrombotic Therapy for Patients with Aortic Stenosis Undergoing Transcatheter Aortic Valve Replacement – JAMA Cardiology (free for a limited period)

 

9 – Association of Preoperative Patient Frailty and Operative Stress With Postoperative Mortality – JAMA Surgery (free for a limited period)

Commentaries: Looking Beyond Mortality Among Older Adults Who Are Frail and Considering Surgical Intervention – JAMA Surgery (free for a limited period) AND No such thing as a low-risk surgery for frail patients – Vanderbilt University Medical Center (free) AND Even low-stress surgery can be fatal for frail patients, study finds – University of Texas Health Center at San Antonio (free)

 

10 – Interplay of Coronary Artery Calcium and Risk Factors for Predicting CVD/CHD Mortality: The CAC Consortium – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentary: Coronary Artery Calcium and Risk Factors for Predicting Mortality – American College of Cardiology (free)

Related Study: Association of Coronary Artery Calcium With Long-term, Cause-Specific Mortality Among Young Adults (free study and commentary)

 


 

1 – 2019 AHA/ACC Clinical Performance and Quality Measures for Adults with High Blood Pressure – Journal of the American College of Cardiology (free)

Commentaries: New Performance and Quality Measures For High BP Released – American College of Cardiology (free) AND Heart Groups Publish New Performance, Quality Measures for BP Management – NEJM Journal Watch (free)

Related AHA/ACC Guideline and Summaries: 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults (free) AND Executive Summary (free) AND Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 ACC/AHA Hypertension Guideline – Annals of Internal Medicine (free)

 

2 – Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Headache – Annals of Emergency Medicine (free)

 

3 – Consensus Statement on Sports-Related Concussions in Youth Sports Using a Modified Delphi Approach – JAMA Pediatrics (free for a limited period)

Commentary: Evidence Lacking on Ways to Prevent Youth Sports Concussion – NEJM Journal Watch (free)

 

4 – Initial Imaging-Guided Strategy Versus Routine Care in Patients with Non–ST-Segment Elevation Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Upfront Imaging Reduces Invasive Angiography in Patients With Unclear NSTEMI Diagnosis – TCTMD (free) AND Imaging-Guided Strategy vs. Routine Care for NSTEMI Patients – American College of Cardiology (free)

 

5 – STI update: Testing, treatment, and emerging threats – Cleveland Clinic Journal of Medicine (free)

 

6 – Appropriate laboratory testing in Lyme disease – Cleveland Clinic Journal of Medicine (free)

 

7 – Artificial Intelligence examining ECGs predicts irregular heartbeat, death risk – American Heart Association Scientific Sessions (free)

Related Study: Artificial Intelligence Algorithm Can Detect Patients with Atrial Fibrillation from a Sinus Rhythm ECG (link to abstract and commentaries)

 

8 – How to Read Articles That Use Machine Learning: Users’ Guides to the Medical Literature – JAMA (free for a limited period)

Editorial: Evaluating Machine Learning Articles (free)

 

9 – Drugs for Atrial Fibrillation – JAMA (free for a limited period)

Podcast: Review of Atrial Fibrillation Treatment – JAMA (free audio)

Original Guideline: 2019 AHA/ACC/HRS Focused Update of the 2014 AHA/ACC/HRS Guideline for the Management of Patients With Atrial Fibrillation (free)

 

10 – Otology/Neurotology recommendations – Choosing Wisely campaign – Journal of Otolaryngology – Head & Neck Surgery (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 


 

1 – Cannabis-based medicinal products – National Institute for Health and Care Excellence (free)

Commentaries: Drug experts on the new guidance for medicinal cannabis – The Conversation (free) AND Ian Hamilton: New guidelines for prescribing medicinal cannabis—another dashed hope for patients – The BMJ Opinion (free)

Related: Guideline for Prescribing Medical Cannabinoids in Primary Care – Canadian Family Physician (free) AND Cannabinoids for Chronic Pain – Therapeutics Initiative AND (free) Meta-Analysis: Insufficient Evidence for The Use of Cannabinoids for Treating Mental Disorders – The Lancet Psychiatry (link to abstract and commentaries) AND The Effects of Cannabis Among Adults With Chronic Pain – Annals of Internal Medicine (link to abstract and commentaries)

“In short, NICE has concluded that more research is needed before it can recommend the use of cannabis-based products for medicinal use.” (from The Conversation)

 

2 – Clinical Practice Guidelines for The Perioperative Nutrition, Metabolic, And Nonsurgical Support of Patients Undergoing Bariatric Procedures – 2019 Update: Cosponsored By American Association Of Clinical Endocrinologists/American College Of Endocrinology, The Obesity Society, American Society For Metabolic & Bariatric Surgery, Obesity Medicine Association, And American Society Of Anesthesiologists (free PDF)

 

3 – O-RADS US Risk Stratification and Management System: A Consensus Guideline from the ACR Ovarian-Adnexal Reporting and Data System Committee – Radiology (free)

 

4 – Results of a 6-week treatment with 10 mg prednisolone in patients with hand osteoarthritis (HOPE): a double-blind, randomised, placebo-controlled trial – The Lancet (free registration required)

Commentaries: Low-Dose Oral Prednisolone Substantially Improves Pain and Function in Hand Osteoarthritis – American College of Rheumatology (free) AND Short-term prednisolone offers HOPE for painful hand osteoarthritis – Medicine Matters (free) AND Short Course of Low-Dose Prednisolone for Painful Hand Osteoarthritis – MedicalResearch.com (free)

#ACR19 – Just Presented at the 2019 American College of Rheumatology Annual Meeting

 

5 – Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism – JAMA Internal Medicine (free for a limited period)

 

6 – A Randomized Trial of a 1-Hour Troponin T Protocol in Suspected Acute Coronary Syndromes – Circulation (free for a limited period)

Commentaries: World-First Trial Cuts ED Wait Times and Admissions – Flinders University (free) AND Ruling Out MI Safe With 0/1-Hour High-Sensitivity Troponin: RAPID-TNT – TCTMD (free)

Related Studies/Commentaries Highlighting Problems with High-sensitivity Cardiac Troponin: Myths in Emergency Medicine: Is hs-cTnT Worth the Downstream Testing? – Emergency Medicine News (free) AND Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome – The Lancet (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival – Journal of the American College of Cardiology (free) AND Cohort Study: High Sensitivity Cardiac Troponin May Result in Misdiagnosis of Acute Myocardial Infarction – The BMJ (free)

 

7 – Aspirin for primary prevention of cardiovascular disease: a meta-analysis with a particular focus on subgroups – BMC Medicine (free)

Related: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free) AND Benefits and Harms of Aspirin for Primary Prevention of Cardiovascular Disease – Annals of Internal Medicine (link to abstract and commentaries) AND Aspirin for Primary Prevention: Is This the End of the Road? (selection of resources on the subject)

 

8 – Lipid-based nutrient supplements and all-cause mortality in children 6–24 months of age: a meta-analysis of randomized controlled trials – American Journal of Clinical Nutrition (free)

Commentaries: Nutrient supplements significantly reduce child deaths – University of California (free) AND Children receiving small-quantity lipid-based nutrient supplementary foods have lower mortality rates – American Society for Nutrition (free)

 

9 – Review: Sleep-Related Disorders in Neurology and Psychiatry – Deutsches Ärzteblatt international (free)

 

10 – Onco-Nephrology: Cancer, chemotherapy and kidney – Nephrología (free)

Related: Onco-Nephrology: Core Curriculum – American Journal of Kidney Diseases (free) AND Onco-nephrology: an appraisal of the cancer and chronic kidney disease links – Nephrology Dialysis Transplantation (free) AND Opening an onconephrology clinic: recommendations and basic requirements – Nephrology Dialysis Transplantation (free) AND Onco-nephrology: current concepts and future perspectives – Japanese Journal of Clinical Oncology (free)

 


 

1 – Development of Risk Prediction Equations for Incident Chronic Kidney Disease – JAMA (free for a limited period)

See Calculator: Risk of Developing Reduced Kidney Function (free tool)

Editorial: Predicting Risk of Kidney Disease: Is Risk-Based Kidney Care on the Horizon? – JAMA (free for a limited period)

Commentaries: New Tool Predicts Five-Year Risk of Chronic Kidney Disease With High Accuracy – Johns Hopkins Bloomberg School of Public Health (free) AND Researchers Develop Tool to Identify Those at Risk of Future CKD – AJMC (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

2 – Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials – JAMA (free for a limited period)

Commentary: Supplements don’t preserve kidney health in Type 2 diabetes – University of Washington School of Medicine (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

3 – Association of Baclofen with Encephalopathy in Patients With Chronic Kidney Disease – JAMA (free for a limited period)

Commentary: Common muscle relaxant causes severe confusion in patients with kidney disease – University of Western Ontario (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

4 – A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Novel Drug Eases Uremic Pruritus – Renal & Urology News (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

5 – Mycophenolate Mofetil versus Azathioprine in Kidney Transplant Recipients on Steroid-Free Low-Dose Cyclosporine Immunosuppression: The ATHENA Trial – 2019 American Transplant Congress (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

6 – CDC Reports: Risk Factors for E-Cigarette, or Vaping, Product Use–Associated Lung Injury (EVALI) Among Adults Who Use E-Cigarette, or Vaping, Products — Illinois, July–October 2019 (free) AND Evaluation of Bronchoalveolar Lavage Fluid from Patients in an Outbreak of E-cigarette, or Vaping, Product Use–Associated Lung Injury — 10 States, August–October 2019 (free)

Commentaries: In a breakthrough, health officials identify possible culprit behind vaping illnesses: vitamin E acetate – STAT (free) AND Vaping Illnesses Are Linked to Vitamin E Acetate, C.D.C. Says – The New York Times (10 articles per month are free) AND CDC Finds Possible Culprit In Outbreak Of Vaping-Related Lung Injuries – NPR (free)

Related: Viewpoint: Vaping—Seeking Clarity in a Time of Uncertainty (free) AND “EVALI” (e-cigarette, or vaping, product use-associated lung injury): CDC Updates Guidance and Creates New Name (free)

 

7 – Updated Cardiovascular Prevention Guideline of the Brazilian Society of Cardiology – 2019 – Arquivos Brasileiros de Cardiologia (free PDF)

Related Guidelines: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free guideline and resources) AND Cardiovascular disease: risk assessment and reduction, including lipid modification – National Institute for Health and Care Excellence (free) AND Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update – Canadian Medical Association Journal (free)

 

8 – #181 The Multimorbidity Games with Josh Uy MD – The Curbsiders Internal Medicine Podcast (free audio)

See also: Episode List

Related: Multimorbidity: clinical assessment and management – NICE Guideline (free) AND Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology (free) AND Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal (free) AND Multimorbidity: a priority for global health research – The Academy of Medical Sciences (free)

 

9 – Association of Autofluorescence-Based Detection of the Parathyroid Glands During Total Thyroidectomy With Postoperative Hypocalcemia Risk: Results of the PARAFLUO Multicenter Randomized Clinical Trial – JAMA Surgery (free for a limited period)

Invited Commentary: New Technique to Reduce the Risk For Hypocalcemia in Thyroid Surgery (free for a limited period)

 

10 – UPDATE: The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication – U.S Food and Drug Administration (free)

Commentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)

“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”

 


 

1 – Subclinical and Device-Detected Atrial Fibrillation: Pondering the Knowledge Gap: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentary: The Management of Subclinical Atrial Fibrillation: The Pathway to True Medical Expertise – American Heart Association (free)

Top Things to Know: Subclinical and Device-Detected Atrial Fibrillation (free)

Related: Apple Watch Can Spot Atrial Fibrillation, But More Research is Needed (several commentaries on the subject)

 

2 – Vaping—Seeking Clarity in a Time of Uncertainty – JAMA (free for a limited period)

Author Interview: Vaping—Seeking Clarity in a Time of Uncertainty (free audio)

Related: “EVALI” (e-cigarette, or vaping, product use-associated lung injury): CDC Updates Guidance and Creates New Name (free)

 

3 – Cardiovascular risk of electronic cigarettes: a review of preclinical and clinical studies – Cardiovascular Research (free)

Commentaries: Vaping not worth potential heart risk, researchers say – Ohio State University (free) AND Vaping risks significant, says new review – News Medical (free) AND E-cigs may damage the heart, study says – MedicalXpress (free)

 

4 – Strategies to reduce non-ventilator-associated hospital-acquired pneumonia: A systematic review – Infections, Disease & Health (free)

 

5 – Effect of lung recruitment maneuver on oxygenation, physiological parameters and mortality in acute respiratory distress syndrome patients: a systematic review and meta-analysis – Intensive Care Medicine (free)

Related: Alveolar recruitment in acute respiratory distress syndrome: should we open the lung (no matter what) or may accept (part of) the lung closed? – Intensive Care Medicine (free) AND Recruitment maneuver does not provide any mortality benefit over lung protective strategy ventilation in adult patients with acute respiratory distress syndrome: a meta-analysis and systematic review of the randomized controlled trials – Journal of Intensive Care (free) AND Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free study and editorial)

 

6 – Randomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)

Source: EvidenceAlerts

“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”

 

7 – Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients – Nature Medicine (link to abstract – $ for full-text)

Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)

 

8 – American Academy of Pediatrics – Section on Surgery: Five Things Physicians and Patients Should Question – Choosing Wisely (free)

Commentary: Choosing Wisely Examines Pediatric Surgical Practices to Avoid – NEJM Journal Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

9 – Ann Robinson’s journal review, 7 November 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 

10 – Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: A 10-year cohort – Neurology (free PDF)

Commentaries: Difficulty sleeping linked with raised risk of heart attack and stroke – NHS Choices (free) AND Insomnia in adults linked to heart attack and stroke – CNN (free) AND Insomnia maybe a significant risk factor for heart attacks and strokes – News Medical (free)

 


 

1 – Efficacy of a Tetravalent Dengue Vaccine in Healthy Children and Adolescents – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: A Takeda vaccine for dengue appears effective, but the story is nuanced – STAT (free) AND A new dengue vaccine shows promise — at least for now – ScienceNews (free) AND New dengue vaccine performs well in large trial, but safety remains key concern – Science (a few articles per month are free) AND Takeda’s dengue vaccine effective overall in study but with major limitation – Reuters (free)

 

2 – Prevention of Early Ventilator-Associated Pneumonia after Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Routine Antibiotics Help Ventilated Patients After Cardiac Arrest – MedPage Today (free registration required)

 

3 – 2019 HRS expert consensus statement on evaluation, risk stratification, and management of arrhythmogenic cardiomyopathy: Executive summary – Heart Rhythm (free)

Full Guideline: 2019 HRS Expert Consensus Statement on Evaluation, Risk Stratification, and Management of Arrhythmogenic Cardiomyopathy (free guideline and commentary)

 

4 – 2019 Canadian Cardiovascular Society Position Statement for Transcatheter Aortic Valve Implantation – Canadian Journal of Cardiology (free)

Related Guidelines: Interdisciplinary consensus on indications for transfemoral transcatheter aortic valve implantation (TF-TAVI) – Clinical Research in Cardiology (free) AND 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease (free) AND 2017 ESC/EACTS Guidelines for the management of valvular heart disease (free)

 

5 – Ten things ICU specialists need to know about new valvular procedures in interventional cardiology – Intensive Care Medicine (free)

 

6 – Vasopressor therapy in critically ill patients with shock – Intensive Care Medicine (free)

Related: Editorial: Focus on Blood Pressure Targets and Vasopressors in Critically Ill Patients (free editorial and reviews)

 

7 – 150 years of Nature – A Century and a Half of Research and Discovery (free resources)

Video (interesting): A network of science: 150 years of Nature papers (free)

 

8 – Association between gifts from pharmaceutical companies to French general practitioners and their drug prescribing patterns in 2016: retrospective study using the French Transparency in Healthcare and National Health Data System databases – The BMJ (free)

 

9 – Association of contrast and acute kidney injury in the critically ill: A propensity matched study – CHEST (link to abstract – $ for full-text)

Commentary: No association between contrast use and AKI seen in critically ill patients with normal kidney function – ACP Hospitalist (free)

Related: Does contrast cause kidney injury? The evidence – First10EM (free) AND Are the Risks Of Drugs That Enhance Imaging Tests Overblown? – NPR (free) AND Acute Kidney Injury After Computed Tomography: A Meta-analysis – Annals of Emergency Medicine (link to abstract – $ for full-text) AND Risk of Acute Kidney Injury After Intravenous Contrast Media Administration – Annals of Emergency Medicine (link to abstract – $ for full-text) AND

 

10 – Associations Between Screen-Based Media Use and Brain White Matter Integrity in Preschool-Aged Children – JAMA Pediatrics (free for a limited period)

Commentaries: Expert reaction to study on screen use and white brain matter in children – Science Media Centre (free) AND Preschoolers’ Screen Time Tied to Brain Structure Irregularities – MedPage Today (free registration required)

Related: Meta-Analysis: Association Between Screen Media Use and Academic Performance Among Children and Adolescents (link to abstract and commentaries)

 


 

1 – Wilderness Medical Society Clinical Practice Guidelines for the Treatment and Prevention of Drowning: 2019 Update – Wilderness and Environmental Medicine (free)

Related Guidelines: Prevention of Drowning – American Academy of Pediatrics (free) AND Preventing drowning: an implementation guide – World Health Organization (free PDF) AND Global report on drowning: preventing a leading killer – World Health Organization (free PDF) Report: Open Water Drowning and Risks for Children (free)

 

2 – Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Acute Altitude Illness: 2019 Update – Wilderness and Environmental Medicine (free)

Related: Interventions for treating acute high altitude illness – Cochrane Library (free) AND Interventions for preventing high altitude illness: Part 1. Commonly‐used classes of drugs – Cochrane Library (free) AND Interventions for preventing high altitude illness: Part 2. Less commonly‐used drugs – Cochrane Library (free) AND Interventions for preventing high altitude illness: Part 3. Miscellaneous and non‐pharmacological interventions – Cochrane Library (free) AND Acute high-altitude sickness – European Respiratory Review (free) AND High-altitude illness: Management approach – Turkish Journal of Emergency Medicine (free)

 

3 – Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Heat Illness: 2019 Update – Wilderness and Environmental Medicine (free)

Related: National Athletic Trainers’ Association Position Statement: Exertional Heat Illnesses (free) AND Heat stroke – Journal of Intensive Care (free)

 

4 – Wilderness Medical Society Clinical Practice Guidelines for Water Disinfection for Wilderness, International Travel, and Austere Situations – Wilderness and Environmental Medicine (free)

 

5 – Benefits and harms of intensive glycemic control in patients with type 2 diabetes – The BMJ (free for a limited period)

 

6 – Internet based vestibular rehabilitation with and without physiotherapy support for adults aged 50 and older with a chronic vestibular syndrome in general practice: three armed randomised controlled trial – The BMJ (free)

Commentaries: Treat dizziness and vertigo with vestibular rehabilitation – The BMJ Opinion (free) AND Online Intervention Could Help Those with Chronic Vestibular Syndrome – NEJM Journal Watch (free)

Related Study: Internet-Based Vestibular Rehabilitation for Older Adults With Chronic Dizziness (free study and commentaries)

 

7 – Incidence of Bloodstream Infections, Length of Hospital Stay, and Survival in Patients With Recurrent Clostridioides difficile Infection Treated With Fecal Microbiota Transplantation or Antibiotics: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Study: Fecal Transplants Cut Sepsis Risk in Patients With C. Diff – MedPage Today (free registration required)

Related: Clostridioides Difficile: Diagnosis and Treatments (free guidelines and reviews)

 

8 – Early Palliative Care Consultation in the Medical ICU: A Cluster Randomized Crossover Trial – Critical Care Medicine (link to abstract – $ for full-text)

Source: EvidenceAlerts

 

9 – Short-Term Impact of a Flavored Tobacco Restriction: Changes in Youth Tobacco Use in a Massachusetts Community – American Journal of Preventive Medicine (free for a limited period)

Commentaries: Restricting flavored tobacco could curb youth use – Reuters (free) AND A tale of two cities: Impact of reducing teens’ access to flavored tobacco products – Elsevier (free) AND One town’s flavor ban seemed to work to cut youth tobacco use – CNN (free)

Related Opinion: Ban Flavored E-Cigarettes to Protect Our Children (free commentaries)

 

10 – Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Commentaries: Study highlights role of mind-body therapies in addressing opioid-treated pain – News Medical (free) AND Meditation, Mindfulness Hold Promise for Pain Treatment, Curbing Opioid Use – U.S. News (free)

 


 

1 – Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults: A Guidance Statement From the American College of Physicians – Annals of Internal Medicine (free)

News Release: ACP issues guidance for colorectal cancer screening – American College of Physicians (free)

Summaries for Patients: Colorectal Cancer Screening in Average-Risk Adults (free)

Commentaries: ACP issues new guidance on colorectal cancer screening – ACP Internist (free) AND Medical groups differ on when to start colon and rectal cancer screening. Here’s why – CNN (free)

Related: BMJ Guideline: Colorectal Cancer Screening with Fecal Immunochemical Testing, Sigmoidoscopy or Colonoscopy (recent guideline suggesting a more selective approach to screening) AND Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society (recent guideline with recommendation to start screening at 45 years, with links to guidelines from other organizations)

 

2 – Clinical practice guideline on pregnancy and renal disease – BMC Nephrology (free)

 

3 – Follow-up of patients after revascularisation for peripheral arterial diseases: a consensus document from the European Society of Cardiology Working Group on Aorta and Peripheral Vascular Diseases and the European Society for Vascular Surgery – European Journal of Preventive Cardiology (free)

 

4 – A systematic review of guidelines for managing rheumatoid arthritis – BMC Rheumatology (free)

Related Guidelines: Rheumatoid arthritis in adults: management – National Institute for Health and Care Excellence (free) AND 2015 American College of Rheumatology Guideline for the Treatment of Rheumatoid Arthritis (free)

 

5 – Podcast: Random Pearls in Pulmonary Medicine and Critical Care from #CHEST2019 in New Orleans

#179 CHEST 2019 Recap Part 1 – The Curbsiders Internal Medicine Podcast (free audio)

#180 CHEST 2019 Recap Part 2 from New Orleans – The Curbsiders Internal Medicine Podcast (free audio)

 

6 – Thirteen Things Physicians and Patients Should Question – Choosing Wisely Canada (free)

Related: American Academy of Family Physicians: Twenty Things Physicians and Patients Should Question (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

7 – Correlation confounded by timing: One reason we believe bad therapies are awesome – PulmCrit (free)

 

8 – Are Daylight Saving Time Changes Bad for the Brain? – JAMA Neurology (free for a limited period)

Commentaries: Daylight Saving Time Has Long-term Effects on Health – Vanderbilt University Medical Center (free) AND Some Neurologists Want To End Daylight Saving Time, Calling It Unhealthy – Newsweek (free)

 

9 – Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials – British Journal of Psychiatry (free)

News Release: Fish oil supplements have no effect on anxiety and depression – University of East Anglia (free)

 

10 – Lower Blood Pressure After Transcatheter or Surgical Aortic Valve Replacement is Associated with Increased Mortality – Journal of the American Heart Association (free)

Editorial: The Pressure Is On: Implications of Blood Pressure After Aortic Valve Replacement (free)

 


 

1 – European Respiratory Society guidelines on long-term home non-invasive ventilation for management of COPD – European Respiratory Journal (free)

Source: EvidenceAlerts

 

2 – EULAR recommendations for the management of Sjögren’s syndrome with topical and systemic therapies – Annals of Rheumatic Disease (free)

Related Guideline: The British Society for Rheumatology guideline for the management of adults with primary Sjögren’s Syndrome – Rheumatology (free)

 

3 – Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis – British Journal of Sports Medicine (free)

 

4 – Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care – Annals of Rheumatic Diseases (free)

 

5 – Therapeutic-induced hypertension in patients with noncardioembolic acute stroke – Neurology (link to abstract – $ for full-text)

 

6 – The EMR has changed the doctor-patient duet into a ménage-à-trois – STAT (free)

Related: How Tech Can Turn Doctors Into Clerical Workers – The New York Times Magazine (10 articles per month are free) AND Date Night with the EHR – NEJM Catalyst (free) AND Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free) AND Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout – National Academy of Medicine (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record – Harvard Business Review (a few articles per month are free)

 

7 – Podcast: Emerging Applications for Ketamine – JAMA (free audio)

Related Resources:

Ketamine for Pain: Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists (free)

Ketamine for Depression: Ketamine and depression: a narrative review – Drug Design, Development and Therapy (free)

 

8 – Alex Nowbar’s weekly review, 1 November 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 

9 – Vaccines for International Travel – Mayo Clinic Proceedings (free)

See also: Just Released. 2020 Edition of CDC Traveler’s Health Yellow Book (free resources)

 

10 – The Incidence, Causes, and Risk Factors of Acute Kidney Injury in Patients Receiving Immune Checkpoint Inhibitors – Clinical Journal of the American Society of Nephrology (free for a limited period)

News Release: Study Examines Kidney Injury in Patients Taking Immunotherapy Cancer Medications – American Society of Nephrology (free)

Related: Immune Checkpoint Inhibitor Toxicities (free guidelines and reviews on the subject)

 


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