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NEWS - TOP 10 Medical News Stories

 

1 – Global Tuberculosis Report 2018 – World Health Organization (free PDF)

Commentaries: UN tuberculosis summit ‘historic opportunity’ to put response ‘back on track’: new WHO report – UN News (free) AND WHO TB Report Sets Stage for Historic U.N.TB Meeting – American Thoracic Society (free) AND WHO report warns efforts to end TB are falling short – CIDRAP (free)

 

2 – Positive Pressure Ventilation in the Cardiac Intensive Care Unit – Journal of the American College of Cardiology (free for a limited period) (via @Abraham_RMI)

 

3 – Can Artificial Intelligence Reliably Report Chest X-Rays?: Radiologist Validation of an Algorithm trained on 1.2 Million X-Rays – Cornell University Library (free PDF)

News Release: Qure.ai’s qXR Algorithm can ID Abnormal Chest X-rays With Unprecedented Accuracy (free)

Commentary: AI algorithm IDs abnormal chest x-rays with 90% accuracy – Health Imaging (free) AND AI startup trains algorithm with 1.2M chest x-rays, confirms its accuracy – Radiology Business (free)

 

4 – Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning – Nature Medicine (link to abstract – $ for full-text)

Commentaries: Artificial intelligence can determine lung cancer type – eCancer News (free) AND Google AI Tool Identifies a Tumor’s Mutations From An Image – WIRED (free)

 

5 – Behavioral Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Author Interview: USPSTF Recommendation: Behavioral Interventions to Prevent Adult Obesity-Related Outcomes (free)

Editorials: Weight Management in Adults With Obesity: What Is a Primary Care Clinician to Do? (free for a limited period) AND Treating Obesity—Moving From Recommendation to Implementation (free for a limited period)

Commentaries: Intensive lifestyle changes best for people with BMI above 30, task force says – UPI (free) AND Doctors Should Send Obese Patients To Diet Counseling, Panel Says. But Many Don’t – NPR (free)

 

6 – Efficacy and Safety of Short‐term Dual Antiplatelet Therapy (≤ 6 Months) after Percutaneous Coronary Intervention for Acute Coronary Syndrome; A Systematic Review and Meta‐analysis of Randomized Controlled Trials – Clinical Cardiology (free PDF)

 

7 – Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories – Cell Metabolism (link to abstract and infographic – $ for full-text)

Commentaries: Fasting increases health and lifespan in male mice – NIH Research Matters (free) AND Study: Mice healthier, live longer with increased daily fasting times – UPI (free) AND Study: Daily Fasting Improves Health and Longevity in Male Mice – Sci News (free)

 

8 – Higher Whole-Grain Intake Is Associated with Lower Risk of Type 2 Diabetes among Middle-Aged Men and Women: The Danish Diet, Cancer, and Health Cohort – The Journal of Nutrition (link to abstract – $ for full-text)

Commentary: What you need to know about claims that whole grains can prevent diabetes – Health News Review (free)

 

9 – Association of Hospital Participation in a Medicare Bundled Payment Program With Volume and Case Mix of Lower Extremity Joint Replacement Episodes – JAMA (link to abstract – $ for full-text)

Commentaries: Can Paying for a Health Problem as a Whole, Not Piece by Piece, Save Medicare Money? – The New York Times (10 articles per month are free) AND Medicare’s Bundled Payment Program–Does it Change Hospital Volume or Case Mix? – MedicalResearch.com (free) AND One of Obamacare’s big experiments to lower costs is working surprisingly well – VOX (free)

 

10 – Prevalence of Burnout Among Physicians: A Systematic Review – JAMA (link to abstract – $ for full-text)

Commentaries: Doctors Today May Be Miserable, But Are They ‘Burnt Out’? – NPR (free) AND Physician burnout taking center stage – Reuters (free) AND Burnout Found to Be Common Among U.S. Resident Physicians – Psychiatric News Alert (free)

Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians (free) AND The Burnout Crisis in American Medicine – The Atlantic (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record (free commentaries)

 


 

1 – Implementing Optimal Team-Based Care to Reduce Clinician Burnout – National Academy of Medicine (free)

Commentaries: Optimal team-based health care is associated with improved patient outcomes and physician well-being – ACP Newsroom (free) AND New Review Shows Team-Based Care May Reduce Physician Burnout – Medscape (free registration required)

 

2 – Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline – Clinical Microbiology and Infection (free)

Related: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America (free)

Source: Critical Care Reviews Newsletter

 

3 – Viewpoint: Probiotic Safety—No Guarantees – JAMA Internal Medicine (free for a limited period)

Related: Probiotics: Does the Evidence Match the Hype? (free articles and commentaries) AND Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries)

 

4 – Zackary Berger’s journal reviews, 17 September 2018 – The BMJ Opinion (free)

Zackary Berger reviews the latest research from the top medical journals.

 

5 – Opinion: Medicine’s Financial Contamination – The New York Times (10 articles per month are free)

 

6 – Infant Walker–Related Injuries in the United States – Pediatrics (free)

News Release: Study: Infant walker injuries support AAP’s call for a ban (free)

Commentaries: As Injuries Continue, Doctors Renew Call For Ban On Infant Walkers – NPR (free) AND Injuries associated with infant walkers still sending children to the emergency department – Nationwide Children’s Hospital (free)

 

7 – Ensuring Comprehensive Care and Support for Transgender and Gender-Diverse Children and Adolescents – Pediatrics (free)

News release: AAP Policy Statement Urges Support and Care of Transgender and Gender-Diverse Children and Adolescents (free) AND New Guidance for Care of Transgender Children, Teenagers – Medscape (free registration required)

 

8 – Let’s stop the burning and the bleeding at Cochrane—there’s too much at stake – The BMJ Opinion (free)

Related: Evidence-based medicine group in turmoil after expulsion of co-founder – Science (free) AND Trish Greenhalgh: The Cochrane Collaboration—what crisis? – The BMJ Opinion (free) AND Cochrane – A sinking ship? – BMJ EBM Spotlight (free) AND Turmoil erupts over expulsion of member from leading evidence-based medicine group – STAT (free)

See also: Statement from Cochrane’s Governing Board (free)

 

9 – Treatments of Primary Basal Cell Carcinoma of the Skin: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (free)

 

10 – Development of a New Classification System for Idiopathic Inflammatory Myopathies Based on Clinical Manifestations and Myositis-Specific Autoantibodies – JAMA Neurology (link to abstract – $ for full-text)

Commentary: New Classification of Idiopathic Inflammatory Myopathies – RheumNow (free)

 


 

1 – Effect of Aspirin on All-Cause Mortality in the Healthy Elderly – New England Journal of Medicine (free) (via @EricTopol)

Related Studies: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly – New England Journal of Medicine (free) AND Effect of Aspirin on Disability-free Survival in the Healthy Elderly – New England Journal of Medicine (free)

Commentaries: Daily low-dose aspirin found to have no effect on healthy life span in older people- NIH News Releases (free) AND Low-Dose Aspirin Late in Life? Healthy People May Not Need It – The New York Times (10 articles per month are free)

 

2 – WHO water, sanitation and hygiene strategy 2018-2025 – World Health Organization (free PDF)

 

3 – Optimizing medications in older adults with cognitive impairment: Considerations for primary care clinicians – Canadian Family Physicians (free)

 

4 – Viewpoint: Antibiotics for Sepsis—Finding the Equilibrium – JAMA (free for a limited period)

 

5 – Shared Decision-Making: Staying Focused on the Ultimate Goal – NEJM Catalyst (free)

 

6 – Ig Nobel win for kidney stone removing roller-coaster – BBC (free)

Related: Ig Nobel prizes honor do-it-yourself colonoscopies, a curious use for postage stamps, and other peculiar research – Science (free)

 

7 – Can health services handle the Apple Watch? – BBC (free)

Related: The New Apple Watch 4: Cardiac Accuracy Unknown, “Game-Changing” Benefits Overblown – The Skeptical Cardiologist (free) AND The New ECG Apple Watch Could do More Harm Than Good – Wired (a few articles per month are free)

See also: New Watch can Help Doctors Monitor your Heart in Real Time (free commentaries)

 

8 – Patients vs. paywalls: Is the U.S. ready for open-access publishing? – STAT (free)

Related: Scientific publishing is a rip-off. We fund the research – it should be free – The Guardian (free) AND cOAlition S: Making Open Access a Reality by 2020 (free Statement and commentaries)

 

9 – Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016 – Centers for Disease Control and Prevention (free)

Commentaries: Chronic Pain Affects 20% of Americans, CDC Reports – MedPage Today (free registration required) AND CDC: About 1 in 5 US Adults Have Chronic Pain – MPR (free) AND One-fifth of American adults experience chronic pain, CDC estimates – CNBC (free)

 

10 – Total Medicare Costs Associated With Diagnosis and Treatment of Prostate Cancer in Elderly Men – JAMA Oncology (link to abstract – $ for full-text)

Commentaries: Are Older Prostate Cancer Patients Overtreated? – MedPage Today (free registration required)

 


 

1 – Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association – Hypertension (free PDF)

News Release: Diagnosing and treating resistant hypertension (free)

Commentaries: Tackling Resistant Hypertension – Opportunities and Challenges (free) AND Heart Group Updates Guidelines on Resistant Hypertension – Physician’s First Watch (free)

Top Ten Things to Know: Resistant Hypertension: Detection, Evaluation, and Management (free PDF)

 

2 – Elevated blood pressure and risk of aortic valve disease: a cohort analysis of 5.4 million UK adults – European Heart Journal (free)

Commentary: Elevated blood pressure is linked to increased risk of aortic valve disease – European Society of Cardiology (free)

 

3 – Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries – CA: A Cancer Journal for Clinicians (free)

See also: Latest global cancer data: Cancer burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018 – International Agency for Research on Cancer (free PDF)

Infographic: Global Cancer Data 2018 (free)

Commentaries: WHO: 9.6 million cancer deaths, 18 million new cases this year – UPI (free) AND Cancer will kill nearly 10 million people this year, report estimates – CNN (free) AND Cancer deaths rise to 9.6 million as populations grow and age – Reuters (free)

 

4 – Are Invasive Procedures Effective for Chronic Pain? A Systematic Review – Pain Medicine (free)

Commentaries: New study questions effectiveness of invasive procedures for chronic pain – The Reis Group (free) AND Invasive Procedures For Chronic Pain Have Not Been Proven to Work – MedicalResearch.com (free)

Related: Needless procedures: knee arthroscopy is one of the most common but least effective surgeries – The Conversation (free)

 

5 – What 21st Century Health Care Should Learn from 20th Century Business – NEJM Catalyst (free)

 

6 – The New ECG Apple Watch Could do More Harm Than Good – Wired (a few articles per month are free) (via @EricTopol)

See also: New Watch can Help Doctors Monitor your Heart in Real Time (free commentaries)

 

7 – Opinion: Scientific publishing is a rip-off. We fund the research – it should be free – The Guardian (free)

Related: cOAlition S: Making Open Access a Reality by 2020 (free Statement and commentaries)

 

8 – Thousands of scientists publish a paper every five days – Nature (free)

Related: Some scientists publish more than 70 papers a year. Here’s how—and why—they do it – Science (free)

 

9 – Effect of organised mammography screening on breast cancer mortality: A population‐based cohort study in Norway – International Journal of Cancer (free)

Commentaries: Breast cancer screening does not reduce mortality – eCancer News (free) AND Danish study attributes improved treatment, not screening, to decline in breast cancer deaths – Health Imaging (free)

 

10 – Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)

Commentaries: Study Discerns Rare Risks of Fatal Side Effects From Cancer Immunotherapy – AJMC (free) AND Fatal Toxicities Rare With Checkpoint Inhibitors – MedicalResearch.com (free)

Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 


 

1 – Guideline: Chronic heart failure in adults: diagnosis and management – National Institute for Health and Care Excellence (free)

 

2 – European Union Standards for Tuberculosis Care – European Centre for Disease Prevention and Control (free PDF in several languages) (via @ECDC_TB and @Onisillos)

 

3 – Review: Arterial Hypertension: Diagnosis and treatment – Deutsches Ärzteblatt international (free)

 

4 – USPSTF Draft Recommendation Statement: Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum (free)

Commentaries: USPSTF Again Recommends Ointment to Prevent Gonococcal Eye Infection in Newborns – Physician’s First Watch (free) AND USPSTF Reaffirms Ocular Prophylaxis for All Newborns – MedPage Today (free)

 

5 – New watch can help doctors monitor your heart in real time – American Heart Association News (free)

See also: The new Apple Watch, with FDA’s blessing, comes with an EKG app – STAT (free)

Related: USPSTF Statement: Screening with Resting or Exercise Electrocardiography (ECG) Not Recommended (free Guideline and commentaries) AND Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? (free commentaries) AND Get Ready For A Tsunami Of ECGs (free commentaries)

 

6 – Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician (free) (via @cantaskforce)

Related: Overdiagnosis across medical disciplines: a scoping review – The BMJ Open (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free) AND Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Position Paper on Overdiagnosis and Action to be Taken – Wonca (free PDF)

 

7 – FDA News Release: FDA takes new steps to address epidemic of youth e-cigarette use, including a historic action against more than 1,300 retailers and 5 major manufacturers for their roles perpetuating youth access (free)

Commentaries: FDA: we might have to ban some e-cigarettes to stop teens from vaping – VOX (free) AND FDA Intensifies Crackdown On E-Cigarette Sales To Teenagers – NPR (free)

“The agency is eyeing a crackdown on flavored e-cigs in the face of an “epidemic” of teen use.” (from VOX)

 

8 – Restrictive compared with liberal red cell transfusion strategies in cardiac surgery: a meta-analysis – European Heart Journal (free)

Related study: Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery (link to abstract)

 

9 – Report: Egg freezing in fertility treatment Trends and figures: 2010-2016 – Human Fertilisation and Embryology Authority (HFEA) (free PDF)

Press release: Age is the key factor for egg freezing success says new HFEA report, as overall treatment numbers remain low (free)

Commentaries: Expert reaction to HFEA report on trends in egg freezing – Science Media Centre (free) AND Freeze eggs before 35 for a better chance of IVF success, says report – The Guardian (free)

 

10 – Factors Associated With Long-term Benzodiazepine Use Among Older Adults – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: 1 in 4 Older Adults Prescribed a Benzodiazepine Goes on to Risky Long-Term Use, Study Finds – Michigan Medicine, via NewsWise (free) AND Long-Term Benzodiazepine Use Common Among Older Adults – Physician’s First Watch (free) AND Factors Predicting Long-term Benzodiazepine Use Identified – Medscape (free registration required) AND Larger Number of Benzodiazepine Pills in Initial Prescription Associated With Long Term Use – MedicalResearch.com (free)

Related: A Quiet Drug Problem Among the Elderly – The New York Times (free) AND Our Other Prescription Drug Problem – New England Journal of Medicine (free) AND Benzodiazepines: our other prescription drug epidemic – STAT (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)

 


 

1 – Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Effect of Piperacillin-Tazobactam vs Meropenem on Mortality in Gram-Negative Bloodstream Infection – JAMA (free)

Commentaries: Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free) AND Drug Combo No Better for Hard-to-Treat Bloodstream Infections – Medscape (free registration required)

“The results do not support the use of Pip/Tazo as 30 d mortality was 12.3% in Pip/Tazo vs 3.7% in Mero arms” (via @CarlosdelRio7 see Tweet)

 

2 – Antibiotics for acute rhinosinusitis in adults – Cochrane Library (free for a limited period)

Summary: Antibiotics for sinus infection of short duration in adults – Cochrane Library (free)

“Considering antibiotic resistance, and the very low incidence of serious complications, we conclude there is no place for antibiotics for people with uncomplicated acute rhinosinusitis.”

 

3 – Opinion: Are We Being Misled About Precision Medicine? – The New York Times (10 articles per month are free)

“Doctors and hospitals love to talk about the cancer patients they’ve saved, and reporters love to write about them. But deaths still vastly outnumber the rare successes.”

 

4 – Comparisons of Guidelines and Recommendations on Managing Antineutrophil Cytoplasmic Antibody–Associated Vasculitis – Kidney International Reports (free)

 

5 – Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free)

“All screening programs do harm, some do good as well.”

 

6 – Last Month in Oncology with Dr. Bishal Gyawali: August 2018 – eCancer News (free)

 

7 – Alex Nowbar’s research reviews, 10 September 2018 – The BMJ (free)

 

8 – How well do you know your anticholinergic (antimuscarinic) drugs? – Therapeutics Initiative (free)

 

9 – Long-term Outcomes of the Effects of Home Blood Pressure Telemonitoring and Pharmacist Management on Blood Pressure Among Adults With Uncontrolled Hypertension: Follow-up of a Cluster Randomized Clinical Trial – JAMA Network Open (free)

Commentary: Pharmacist-Led BP Telemonitoring Intervention Works Up to 1 Year After Program Stops – TCTMD (free)

 

10 – Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: The Lancet: Dairy consumption linked to lower rates of cardiovascular disease and mortality – EurekAlert (free) AND Dairy food in moderation ‘may protect the heart’ – The Guardian (free) AND Is Whole-Fat Dairy Good for the Heart? – New York Times (free)

Related: Meta-Analysis: Cheese consumption and risk of cardiovascular disease (link to abstract and commentaries) AND Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality (free study and commentaries)

“It is not the ultimate seal of approval for recommending whole-fat dairy over its low-fat or skimmed counterparts. Readers should be cautious, and treat this study only as yet another piece of the evidence (albeit a large one) in the literature.”

 


 

World #SuicidePrevention Day Highlights (10 September 2018)

 

1 – Preventing suicide A community engagement toolkit – World Health Organization (free PDF)

Fact Sheet: Suicide – World Health Organization (free)

 

2 – Guideline: Preventing suicide in community and custodial settings – National Institute for Health and Care Excellence (free)

 

3 – Chronic Pain Among Suicide Decedents, 2003 to 2014: Findings From the National Violent Death Reporting System – Annals of Internal Medicine (free)

Editorial: Pain, Opioids, and Suicide Mortality in the United States (free)

Commentaries: Chronic pain may contribute to suicide, study warns – Reuters (free) AND Chronic Pain Tied to Increased Suicide Risk – NEJM Physician’s First Watch (free) AND Increasing rates of chronic pain found among those who die by suicide – ACP Internist (free)

 

4 – It’s Hard for Doctors to Unlearn Things. That’s Costly for All of Us – The New York Times (10 articles per month are free) (via @CaulfieldTim)

 

5 – State of The Art Review: Perioperative lung protective ventilation – The BMJ (free for a limited period)

 

6 – Podcast: #113 Gout: Uric acid targets, urate lowering therapy, and random questions from social media – The Curbsiders Internal Medicine Podcast (free)

 

7 – Lifestyle changes reduce the need for blood pressure medications – American Heart Association Meeting Report (free)

Commentary: Lifestyle Interventions Cut Need for Antihypertensives Within Months – NEJM Physician’s First Watch (free)

 

8 – Pharmacist services for non‐hospitalised patients – Cochrane Library (free)

Summary: Can services delivered by pharmacists improve patient health? – Cochrane Library (free)

Commentaries: Pharmacists play vital role in improving patient health shows biggest review of evidence to date – University of Bath (free) AND Community pharmacy can significantly improve care in long-term conditions, large-scale analysis finds – The Pharmaceutical Journal (free)

 

9 – Effectiveness of a Therapeutic Tai Ji QuanIntervention vs a Multimodal Exercise Intervention to Prevent Falls Among Older Adults at High Risk of Falling: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Commentaries: Tai Chi May Work Best to Prevent Falls in Old Age – WebMD (free) AND Tai Ji Quan Can Reduce Falls in Elderly – MedicalResearch.com (free)

 

10 – Preventing Cognitive Decline in Black Individuals With Mild Cognitive Impairment: A Randomized Clinical Trial – JAMA Neurology (free for a limited period)

Commentary: Study provides evidence to prevent memory decline in older blacks with mild cognitive impairment – News Medical (free) AND Novel Intervention Markedly Slows Cognitive Decline in MCI – Medscape (free registration required)

 


 

1 – 2018 European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism – European Thyroid Journal (free) (via @CristobMorales and @Abraham_RMI)

 

2 – Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Pediatric Critical Care Medicine (free)

 

3 – Viewpoint: Aligning Patient and Physician Incentives – JAMA (free for a limited period)

 

4 – Top Cancer Researcher Fails to Disclose Corporate Financial Ties in Major Research Journals – ProPublica (free)

 

5 – Financial Conflicts of Interest Among Oncologist Authors of Reports of Clinical Drug Trials – JAMA Oncology (link to abstract – $ for full-text)

Commentaries: Financial disclosure lacking in publication of clinical trials – eCancer News (free) AND Oncologist-Authors Often Do Not Fully Disclose Financial Relationships with Pharmaceutical Companies – MedicalResearch.com (free) AND One-third of oncologist authors fail to disclosure industry payments – Healio News (free registration required)

 

6 – Palliative care in intensive care units: why, where, what, who, when, how – BMC Anesthesiology (free)

 

7 – Idiopathic Pulmonary Fibrosis (IPF): An Overview – Journal of Clinical Medicine (free)

 

8 – Perspective: The Moral Dilemma of Learning Medicine from the Poor – The Doctors Weight In (free) (via @kennylinafp)

I learned good skills because I was allowed to practice on people who had no other option.”

 

9 – Peer reviewers unmasked: largest global survey reveals trends – Nature News (free)

Original Report: 2018 Global State of Peer Review (free)

 

10 – Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction – JAMA Network Open (free) (via @LuisCLCorreia)

“There is substantial variability in LVEF assessment between modalities, which should be considered in trial design and clinical management.”

 


 

1 – Guideline: Pancreatitis – National Institute for Health and Care Excellence (free)

 

2 – Clinically Localized Prostate Cancer: ASCO Clinical Practice Guideline Endorsement of an American Urological Association/American Society for Radiation Oncology/Society of Urologic Oncology Guideline – Journal of Clinical Oncology (free)

 

3 – Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study – The BMJ (free)

Editorial: Primary prevention with statins for older adults (free)

Commentaries: Expert reaction to study on use of statins in older people – Science Media Centre (free) AND Widespread use of statins in healthy older people to prevent heart disease not recommended in new study – BMJ, via ScienceDaily (free)

New research does not support widespread use of statins in healthy older people to prevent heart disease and stroke. Results found that any protective effect was limited to those with type 2 diabetes aged between 75 and 84” (via @bmj_latest see Tweet)

 

4 – Commission: High-quality health systems in the Sustainable Development Goals era: time for a revolution – The Lancet Global Health (free articles)

Related Article: Mortality due to low-quality health systems in the universal health coverage era: a systematic analysis of amenable deaths in 137 countries – The Lancet (free)

Editorial: Putting quality and people at the centre of health systems – The Lancet (free)

Commentaries: Political and technical barriers to improving quality of health care – The Lancet (free) AND What Kills 5 Million People A Year? It’s Not Just Disease – NPR (free)

Related Report: Crossing the Global Quality Chasm: Improving Health Care Worldwide (free report and commentaries)

 

5 – The 2018 Surviving Sepsis Campaign’s Treatment Bundle: When Guidelines Outpace the Evidence Supporting Their Use – Annals of Emergency Medicine (free) (via @EMNerd)

Related Opinions: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free) AND The Surviving Sepsis Campaign: A Rush to Judgment – NEJM Journal Watch (free)

Original Guideline: The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)

 

6 – Tuberculosis: the curable disease on the rise, and how to tackle it – The Guardian (free)

 

7 – The treatment of anal fistula: second ACPGBI Position Statement – 2018 – Colorectal Disease (free)

 

8 – Guidelines for the Evaluation and Treatment of Perimenopausal Depression: Summary and Recommendations – Journal of Women’s Health (free)

Commentaries: First-Ever Guidelines for Detecting, Treating Perimenopausal Depression – University of Illinois at Chicago, via NewsWise (free) AND Guidelines for Managing Perimenopausal Depression Now Available – MPR (free)

 

9 – A pilot study using telehealth to implement antimicrobial stewardship at two rural Veterans Affairs medical centers – Infection Control & Hospital Epidemiology (free)

News Release: Telehealth Proves Valuable for Promoting Safe Antibiotic Prescribing Practices in Remote Healthcare Settings – Society for Healthcare Epidemiology of America (free)

Commentary: VA pilot study finds telehealth could aid stewardship – CIDRAP (free)

 

10 – Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features – Cell (free)

Related Article: Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT – Cell (free)

Commentaries: Probiotics: Does the evidence match the hype? – Medical News Today (free) AND Probiotics labelled ‘quite useless’ – BBC (free)

 


 

1 – Ten Commandments of the 2018 ESC/ESH HTN Guidelines on Hypertension in Adults – European Heart Journal (free) (via @gonzaeperez)

 

2 – Rapid Recommendations: Prostate cancer screening with prostate-specific antigen (PSA) test: a clinical practice guideline – The BMJ (free)

Related guidelines: American Cancer Society Guideline for the Early Detection of Prostate Cancer (free) AND PSA-Based Prostate Cancer Screening in Men Aged 55-69 – American Academy of Family Physicians (free) AND USPSTF Recommendation Statement: Screening for Prostate Cancer (free guideline, editorial and commentaries)

 

3 – Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

See also: Guideline Update Summary (free)

 

4 – Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Baloxavir for Uncomplicated Influenza (free)

Commentary: New single-dose antiviral cuts flu symptoms, viral loads – CIDRAP (free)

 

5 – Perspective: “Precision” Public Health — Between Novelty and Hype – New England Journal of Medicine (free)

 

6 – Guidance: Writing Outpatient Clinic Letters to Patients – Academy of Medical Royal Colleges (free PDF)

Commentaries: Doctors told to ditch Latin and use ‘plain English’ – BBC News (free) AND New drive to encourage doctors to write to patients in plain English – The Guardian (free) AND Rx for British Doctors: Use Plain English Instead of Latin – The New York Times (free)

“Guidance suggests specialists should avoid Latin terms, acronyms and convoluted language” (from The Guardian)

 

7 – Subsegmental pulmonary embolism: anticoagulation or observation? – PulmCCM (free)

 

8 – Policy Statement: Recommendations for Prevention and Control of Influenza in Children, 2018–2019 – American Academy of Pediatrics (free)

News Release: AAP Issues Flu Vaccine Recommendations for 2018-2019 (free)

 

9 – Diclofenac use and cardiovascular risks: series of nationwide cohort studies – The BMJ (free)

Commentary: Diclofenac Again Tied to Major Cardiovascular Events – NEJM Physician’s First Watch (free) AND ‘A major safety concern’: World’s most common NSAID doubles CVD risk – Cardiovascular Business (free)

 

10 – Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease – PLOS One (free)

Commentaries: AI beats doctors at predicting heart disease deaths – The Francis Crick Institute, via ScienceDaily (free) AND Novel AI algorithm beats cardiologists’ models in predicting heart disease mortality – Cardiovascular Business (free)

 


 

1 – cOAlition S: Making Open Access a Reality by 2020 – Science Europe (free)

See also: 10 principles of Plan S (free PDF) AND Press Release (free PDF)

Commentaries: Radical open-access plan could spell end to journal subscriptions – Nature News (free) AND ‘Plan S’ and ‘cOAlition S’ – Accelerating the transition to full and immediate Open Access to scientific publications – European Commission (free) AND Science without publication paywalls: cOAlition S for the realisation of full and immediate Open Access – PLOS Biology (free)

“…free access to all scientific publications from publicly funded research is a moral right of citizens.” (from European Comission)

 

2 – Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children – JAMA Pediatrics (free)

Commentaries: CDC releases updated guideline on diagnosis and management of pediatric mTBI – Kennedy Krieger Institute, via EurekAlert (free) AND CDC Seeks to Standardize Mild TBI Management in Kids – MedPage Today (free registration required) AND New advice on kids’ concussions calls for better tracking – Associated Press (free) AND CDC issues first guidelines to treat youth concussions – CNN (free)

 

3 – Screening for Syphilis Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement – JAMA (free)

Editorial: Congenital Syphilis—Still a Shadow on the Land (free)

“The USPSTF recommends early screening for syphilis infection in all pregnant women. (A recommendation)”

 

4 – Experts brace for more super-resistant gonorrhea – CIDRAP (free)

 

5 – Perspective: Good Documentation – JAMA (free for a limited period)

“In this narrative medicine essay, the author, who transitioned from paper and pen to computer-generated electronic health record keeping wonders whether the self-select menu items ultimately dehumanizes both the patient and the physician.” (via @JAMA_current see Tweet)

 

6 – Margaret McCartney: A summary of four and a half years of columns in one column – The BMJ (free) (via @oncology_bg)

 

7 – 2018 Korean Clinical Imaging Guideline for Hemoptysis – Korean Journal of Radiology (free)

 

8 – Policy Statement: Child Passenger Safety – American Academy of Pediatrics (free)

News Release: AAP Updates Recommendations on Car Seats for Children (free)

Commentary: Children Should Remain in Rear-Facing Car Seats as Long as Possible – Physician’s First Watch (free)

 

9 – Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1·9 million participants – The Lancet Global Health (free)

Commentaries: Quarter of world’s population ‘not active enough to stay healthy’ – The Guardian (free) AND A quarter of adults are too inactive, putting health at risk – Reuters (free)

 

10 – Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Physician Burnout Poses Risks to Patient Safety – Psychiatric News Alert (free) AND Burnout in doctors doubles risk of patient safety incidents, study finds – Pulse (free)

 


 

1 – Guideline Summary: Medicines for Treatment Intensification in Type 2 Diabetes and Type of Insulin in Type 1 and Type 2 Diabetes in Low-Resource Settings: Synopsis of the World Health Organization Guidelines on Second- and Third-Line Medicines and Type of Insulin for the Control of Blood Glucose Levels in Nonpregnant Adults With Diabetes Mellitus – Annals of Internal Medicine (free)

Original Guideline: Guidelines on second-and third-line medicines and type of insulin for the control of blood glucose levels in non-pregnant adults with diabetes mellitus – World Health Organization (free PDF)

 

2 – Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus – The Journal of Rheumatology (free PDF)

Related Guidelines: The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (PANLAR) – Annals of Rheumatic Diseases (free)

 

3 – The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines – GUT (free)

 

4 – Perspective: Five of the scariest antibiotic-resistant bacteria in the past five years – The Conversation (free)

 

5 – Review: Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk – Journal of the American Heart Association (free)

 

6 – Review: Ischemia and No Obstructive Coronary Artery Disease (INOCA): What Is the Risk – Journal of the American Heart Association? (free)

 

7 – Ann Robinson’s research reviews, 3 September 2018 – The BMJ Opinion (free)

 

8 – Primary antifungal prophylaxis for cryptococcal disease in HIV‐positive people – Cochrane Library (free for a limited period)

Summary: Preventing cryptococcal disease in HIV-positive people – Cochrane Library (free)

Antifungal prophylaxis reduced the risk of developing and dying from cryptococcal disease. Therefore, where CrAG screening is not available, antifungal prophylaxis may be used in patients with low CD4 counts at diagnosis and who are at risk of developing cryptococcal disease.”

 

9 – Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission – JAMA Network Open (free)

Commentary: New prediction rule may help detect delirium at hospital admission – ACP Hospitalist (free)

 

10 – Strategy of endovascular versus open repair for patients with clinical diagnosis of ruptured abdominal aortic aneurysm: the IMPROVE RCT – Health Technology Assessment (free)

Commentary: Endovascular aortic repair (EVAR) surgery more beneficial for ruptured abdominal aortic aneurysms than open repair – NIHR Signal (free)

 


 

1 – Consensus document of the Italian Association of Medical Oncology and the Italian Society of Palliative Care on early palliative care – Tumori Journal (free PDF)

Related Video: Early Palliative Care: a video for health and care professionals – University of Edinburgh (free)

Related Systematic Review: Early palliative care for adults with advanced cancer – Cochrane Library (free) AND Summary: Early palliative care for adults with advanced cancer – Cochrane Library (free)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

2 – Podcast: #111: Hotcakes – Complementary Medicine in Cancer, Dosing Aspirin by Body Weight, Marijuana & Respiratory Symptoms, Penicillin Allergies and More! – The Curbsiders (free audio and summary)

 

3 – Review: Cardiorenal Syndrome Revisited – Circulation (free) (via @Abraham_RMI)

 

4 – “So, Blood Cultures… or No?” – Use of Blood Cultures in the ED – emDocs (free)

Related Review: How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections? A State-of-the Art – Frontiers in Microbiology (free)

 

5 – Government proposes energy drinks ban for children – BBC (free)

Related: England Proposes Ban on Selling Energy Drinks to Children – The New York Times (10 articles per month are free)

 

6 – Abraar Karan: Changing the way we communicate about patients – The BMJ Opinion (free) (via @NUNESDOC)

“Father of 2, retired car salesman and keen on football NOT the colon cancer in Bed 4 – social history brings humanity back to the bedside” (via @hospicedoctor see Tweet)

 

7 – American Epilepsy Society: Five Things Physicians and Patients Should Question – Choosing Wisely (free)

Commentary: Choosing Wisely: 5 Practices to Question When Treating Epilepsy – NEJM Physician’s First Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

8 – Antidepressants for treating depression in dementia – Cochrane Library (free for a limited period)

Summary: Antidepressants for treating depression in dementia – Cochrane Library (free)

“On the only measure of efficacy for which we had high-quality evidence (depression rating scale scores), antidepressants showed little or no effect.”

 

9 – The impact of exposure to air pollution on cognitive performance – Proceedings of the National Academies of Sciences (link to abstract – $ for full-text)

Commentaries: Air pollution could be making us less intelligent – Science Magazine (free) AND Air Pollution Exposure Harms Cognitive Performance, Study Finds – NPR (free) AND Air pollution may harm cognitive intelligence, study says – BBC (free) AND Pollution May Dim Thinking Skills, Study in China Suggests – New York Times (10 articles per month are (free) AND Air pollution is making you less intelligent, according to a new study – World Economic Forum (free)

 

10 – Kawasaki disease: guidelines of the Italian Society of Pediatrics, part I – definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase – Italian Journal of Pediatrics (free)

Part II: Treatment of resistant forms and cardiovascular complications, follow-up, lifestyle and prevention of cardiovascular risks (free)

Related guideline: Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association (free)

Related reviews: Dissecting Kawasaki disease: a state-of-the-art review – European Journal of Pediatrics (free) AND Diagnosis and Management of Kawasaki Disease – American Family Physician (free) AND Controversies in diagnosis and management of Kawasaki disease – World Journal of Clinical Pediatrics (free)

 


 

1 – Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study – The BMJ (free)

Commentaries: Vitamin D: a pseudo-vitamin for a pseudo-disease – The Conversation (free) AND Fracture risk not linked to low vitamin D or calcium levels – OnMedica (free)

Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline)

 

2 – Bacterial Factors That Predict Relapse after Tuberculosis Therapy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Bacterial Factors That Predict Relapse after Antituberculosis Therapy – NEJM Resident 360 (free) AND MICs of Isoniazid, Rifampin May Predict Tuberculosis Relapse – Drugs.com (free) AND Variation in bacterial drug susceptibility tied to TB relapse risk – CHEST Physician (free)

 

3 – Revisiting the timetable of tuberculosis – The BMJ (free)

Related: Soumya Swaminathan: TB programmes should focus on people with highest risk of progression to disease – The BMJ Opinion (free)

 

4 – Clinical Decisions: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome – New England Journal of Medicine (free)

 

5 – 2018 STD Prevention Conference – Centers for Disease Control and Prevention (free)

Press Release: New CDC analysis shows steep and sustained increases in STDs in recent years (free)

Commentaries: 5 reasons why 3 STDs are roaring back in America – VOX (free) AND Rates of three STDs in US reach record high, CDC says – CNN (free) AND Record High Number Of STD Infections In U.S., As Prevention Funding Declines – NPR (free) AND STD cases in U.S. hit record highs as officials warn about resistant gonorrhea – STAT (free) AND US sees record STD cases, rising gonorrhea resistance – CIDRAP (free)

 

6 – Clinical Implications and Challenges of Artificial Intelligence and Deep Learning – JAMA (free for a limited period)

Related Viewpoints: Deep Learning—A Technology With the Potential to Transform Health Care – JAMA (free for a limited period) AND Deep Learning—A Technology With the Potential to Transform Health Care – JAMA (free for a limited period)

 

7 – Publication: Immigration as a Social Determinant of Health: Proceedings of a Workshop – National Academies of Sciences, Engineering, and Medicine (free PDF)

“Immigration as a social determinant of health – NEW publication explores complex interactions between immigration and health disparities + grappling with the complexities of immigration” (via @julianmfisher see Tweet)

 

8 – Optimal Blood Pressure Target in Diabetic and Nondiabetic Hypertensive Patients – Circulation Research (free)

See counterpoint suggesting lower BP targets: Sprinting Toward the Optimal Blood Pressure Target for Hypertensive Patients – Circulation Research (free)

“We have reviewed the randomized trial evidence in favor of a target blood pressure (BP) around 130/80 mm Hg in hypertensive patients with and without diabetes mellitus”

 

9 – Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis – The BMJ (free)

Editorial: Environmental metals and cardiovascular disease (free)

Commentary: Experts warn of cardiovascular risk from heavy metal pollution – University of Cambridge (free)

“Since metals are associated with cardiovascular disease even at relatively low levels of exposure, population wide strategies to minimize exposure can further contribute to overall cardiovascular prevention efforts” (from @bmj_latest see Tweet)

 

10 – Functional Status and Survival After Breast Cancer Surgery in Nursing Home Residents – JAMA Surgery (free for a limited period)

Commentaries: Surgical Decision Making in Elderly, Impaired Nursing Home Patients – JAMA Surgery (free for a limited period) AND For Nursing Home Patients, Breast Cancer Surgery May Do More Harm Than Good – Kaiser Health News (free)

 


 

1 – ESC Council on hypertension position document on the management of hypertensive emergencies – European Heart Journal – Cardiovascular Pharmacotherapy (free) (@Abraham_RMI)

“Patients that lack acute hypertension-mediated end organ damage to the heart, retina, brain, kidneys, or large arteries do not have a hypertensive emergency and can be treated with oral BP-lowering agents and usually discharged after a brief period of observation.”

 

2 – ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)

 

3 – Guideline for the management of hip and knee osteoarthritis – Royal Australian College of General Practitioners (free PDF)

News Release: Updated osteoarthritis guideline designed to reduce unnecessary imaging and surgery (free)

Commentary: Australia hopes to reduce unnecessary imaging, surgery with updated osteoarthritis guidelines – Health Imaging (free)

“The Guideline for the management of knee and hip osteoarthritis,” offer up exercise and weight loss as a first line defense, and warn against costly treatments using glucosamine, opioids and arthroscopic surgery, said David Hunter, co-chair of the RACGP group responsible for the update.” (from Health Imaging)

 

4 – Opinion: Is one drink per day really unsafe? That new alcohol study, explained – VOX (free)

Related Commentary: Study Causes Splash, but Here’s Why You Should Stay Calm on Alcohol’s Risks – The New York Times (10 articles per month are free)

Original Article: Alcohol Use and Burden for 195 Countries and Territories (free study and commentaries)

 

5 – Earwax, Of All Things, Poses Unrecognized Risk In Long-Term Care – Kaiser Health News (free)

“Of all the indignities that come with aging, excessive earwax may be the most insidious… when it goes unrecognized, it can pose serious problems, especially for the 2.2 million people who live in U.S. nursing homes and assisted living centers.”

 

6 – #ESCCongress – Early Versus Standard Care Invasive Examination and Treatment of Patients with Non-ST-Segment Elevation Acute Coronary Syndrome: The VERDICT (Very EaRly vs Deferred Invasive evaluation using Computerized Tomography) – Randomized Controlled Trial – Circulation (free PDF)

Editorial: Timing of Intervention in Non ST Elevation Acute Coronary Syndromes: And the VERDICT is? (free PDF)

Commentaries: VERDICT: Very Early Invasive Coronary Angiography vs. Standard Care in NSTE-ACS Patients- American College of Cardiology (free) AND ESC: Early Invasive Strategy in NSTEMI Does Not Improve Outcomes – MedPage Today (free registration required) AND VERDICT: Very Early Invasive Angiography No Help Overall for NSTE ACS – TCTMD (free)

 

7 – #ESCCongress – Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data – The Lancet (free)

Commentaries: Imaging of coronary inflammation for cardiovascular risk prediction – The Lancet (free) AND New Imaging Biomarker of Coronary Inflammation Shows Prognostic Value Exceeding All Current Noninvasive Measures – Cleveland Clinic (free) AND Imaging biomarker can predict coronary inflammation – UPI (free)

 

8 – #ESCCongress – Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: MATRIX: 1-Year Results Confirm Superiority of Transradial PCI – TCTMD (free) AND Radial vs. Femoral Access for Angiography with or Without Bivalirudin in Patients with Acute Coronary Syndrome – NEJM Journal Watch (free for a limited period) AND ESC: Radial Access Tied to Better 1-Year Outcomes in ACS – MedPage Today (free registration required)

 

9 – #ESCCongress – Psychological Distress and Risk of Myocardial Infarction and Stroke in the 45 and Up Study: A Prospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Distress boosts heart attack and stroke risk – Medical News Today (free) AND High Mental Distress Tied to Heart Troubles – MedPage Today (free registration required)

 

10 – #ESCCongress – Deep forehead wrinkles may signal a higher risk for cardiovascular mortality – ESC Press Releases (free)

Commentaries: Forehead wrinkles – an early sign of cardiovascular disease? – Medical News Today (free) AND Excessive forehead wrinkles may be early sign of atherosclerosis – Cardiovascular Business (free)

 


 

1 – Report: Crossing the Global Quality Chasm: Improving Health Care Worldwide – National Academies Of Sciences, Engineering, and Medicine (free PDF)

News Release: Up to 8 Million Deaths Occur in Low- and Middle-Income Countries Yearly Due to Poor-Quality Health Care, Says New Report; Major Quality Chasm Must Be Fixed in Order to Reap Benefits of Universal Health Coverage (free)

Videos: The Scope of the Problem (free) AND Health Systems of the Future (free)

See also: Report Highlights (free PDF) AND Recommendations (free PDF)

 

2 – #ESCCongress – Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis – New England Journal of Medicine (free for a limited period)

Commentaries: Partial Oral Treatment of Endocarditis – POET – American College of Cardiology (free) AND New treatment can halve hospital stays for some patients with heart infection – ESC Press Releases (free)

 

3 – #ESCCongress – High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial – The Lancet (free)

Commentaries: Diagnosing myocardial infarction: a highly sensitive issue – The Lancet (free) AND Hs-TnI in Suspected ACS: High-STEACS Trial – American College of Cardiology (free)

Introduction of a high-sensitivity cardiac troponin I assay reclassified 1 in 6 patients with previously undetected myocardial necrosis, but did not lead to improved clinical outcomes in this large randomised trial” (via @chapdoc1 see Tweet)

Very important study. What’s weird is that the “better” (more sensitive) troponin assays get, the less helpful the test becomes at the bedside. Look for a coming tsunami of iatrogenesis from overzealous evaluation of troponin bumps.” (via @drjohnm see Tweet)

 

4 – #ESCCongress – One-Year Outcomes after PCI Strategies in Cardiogenic Shock – New England Journal of Medicine (free for a limited period)

Commentaries: Less Is Still More in Patients with Acute Myocardial Infarction and Cardiogenic Shock – NEJM Journal Watch (free for a limited period) AND 1-year outcomes still support culprit-only PCI for cardiogenic shock – Cardiovascular Business (free) AND CULPRIT-SHOCK: 1-Year Results Continue to Support Culprit-Only PCI for Shock Patients – TCTMD (free)

 

5 – #ESCCongress – Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Telemedicine in Heart Failure Patients (TIM-HF2) – American College of Cardiology (free) AND ESC: Telemonitoring of HF Cuts Admissions, Mortality MedPage Today (free registration required)

 

6 – Global Mortality From Firearms, 1990-2016 – JAMA (free for a limited period)

Video Summary: Global Firearm Mortality, 1990-2016 – JAMA (free)

Infographic: Firearm deaths around the world 1990–2016 – Institute for Health Metrics and Evaluation (free) (via @kleachkemon)

Commentaries: Six countries in the Americas account for half of all firearm deaths – Institute for Health Metrics and Evaluation (free) AND Gun-related homicides, suicides kill more people than war, study says – CNN (free)

 

7 – Zackary Berger’s journal reviews, 28 August 2018 – The BMJ Opinion (free)

 

8 – Guide to Statistics and Methods: Case-Control Studies: Using “Real-world” Evidence to Assess Association – JAMA (free for a limited period)

 

9 – Guiding Principles for the Care of People With or at Risk for Diabetes – National Institute of Diabetes and Digestive and Kidney Diseases (free PDF)

Commentaries: NIDDK Updates ‘Guiding Principles’ for Diabetes, Prediabetes – Medscape (free registration required) AND NDEP revises principles for managing diabetes, prediabetes – Cardiovascular Business (free)

Related Book: Diabetes in America, 3rd Edition – National Institutes of Health (free reference book, just released)

 

10 – Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015 – Nature Human Behavior (free for a limited period)

Commentaries: More social science studies just failed to replicate. Here’s why this is good – VOX (free) AND High-profile journals put to reproducibility test – Nature News (free) AND ‘Replication crisis’ spurs reforms in how science studies are done – ScienceNews (free) AND The Science Behind Social Science Gets Shaken Up—Again – WIRED (Free) AND In Psychology And Other Social Sciences, Many Studies Fail The Reproducibility Test – NPR (free)

We replicated 21 social science experiments in Science or Nature. We succeeded with 13. Replication effect sizes were half of originals.” (via @BrianNosek see Tweet)

 


 

1 – Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal (free)

Commentaries: Care coordination improves health of older patients with multiple chronic diseases – CMAJ, via EurekAlert (free) AND Seniors healthier when medical care is coordinated – Reuters (free)

Related: Ten Recommendations: Designing a High-Performing Health Care System for Patients with Complex Needs (free Guidance and related perspectives) AND Multimorbidity: A Priority for Global Health Research (free research and commentaries)

 

2 – A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction – Circulation (free) (via @CircAHA see Tweet with Infographic)

Editorial: H2FPEF Score: At Last, a Properly Validated Diagnostic Algorithm for Heart Failure With Preserved Ejection Fraction (free)

 

3 – Clinical Guideline Synopsis: Diagnosis and Treatment of Clostridium difficile Infection – JAMA (free for a limited period) (via @ABsteward and @Abraham_RMI)

Original Guideline: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free)

 

4 – Review: Acute Clinical Care for Transgender Patients – JAMA Internal Medicine (free for a limited period) (via @CarlosdelRio7)

 

5 – Antithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report (free PDF)

News Release: The American College of Chest Physicians updates their antithrombotic therapy guidelines for patients with atrial fibrillation (free)

 

6 – Clinical Report: Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes – Pediatrics (free)

News Release: Counsel against marijuana use in pregnancy, breastfeeding – American Academy of Pediatrics (free)

Related Article: Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk – Pediatrics (free)

Commentaries: A Modern Conundrum for the Pediatrician: The Safety of Breast Milk and the Cannabis-Using Mother – Pediatrics (free) AND Marijuana study finds THC in breast milk up to 6 days after mom’s use – CNN (free) AND Pediatricians Put It Bluntly: Motherhood And Marijuana Don’t Mix – Kaiser Health News (free) AND Clinical report provides guidance on marijuana use in pregnancy and lactation – 2 Minute Medicine (free)

 

7 – #ESCCongress – Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus – New England Journal of Medicine (free for a limited period)

Commentaries: Fish oils do not prevent heart attack or strokes in people with diabetes – ESC News Releases (free) AND Omega-3 Fatty Acids Fail to Reduce CVD Events in Diabetic Patients: ASCEND – TCTMD (free)

Related Cochrane Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (link to abstract and commentaries)

Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free study and commentary)

 

8 – #ESCCongress – Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients – New England Journal of Medicine (free for a limited period)

Editorial: Lorcaserin — Elixir or Liability? (free for a limited period)

Commentaries: CAMELLIA-TIMI 61: Weight Loss Drug Lorcaserin Did Not Increase CV Events – American College of Cardiology (free) AND Weight-Loss Drug Lorcaserin Clears Cardiovascular Safety Hurdle: CAMELLIA-TIMI 61 – TCTMD (free) AND Weight loss drug lorcaserin found safe in large study – Reuters (free)

 

9 – #ESCCongress – Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness – New England Journal of Medicine (free for a limited period)

Commentaries: VTE risk unchanged by rivaroxaban after discharge – The Hospitalist (free) AND MARINER: Rivaroxaban vs. Placebo Post-Discharge in Patients at High Risk For VTE – American College of Cardiology (free) AND MARINER: No Reduction in Death, VTE With Rivaroxaban After Discharge in Medically Ill Patients – Medscape (free registration required)

 

10 – #ESCCongress – Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy – New England Journal of Medicine (free for a limited period)

Editorial: Stabilizing Transthyretin to Treat ATTR Cardiomyopathy (free for a limited period)

Commentaries: Tafamidis, a Transthyretin Stabilizer, Offers Hope for Rare Cardiomyopathy – TCTMD (free) AND ATTR-ACT: Tafamidis Findings Offer Hope For Patients With ATTR-CM – American College of Cardiology (free) AND Drug reduces deaths and hospitalizations from underdiagnosed form of heart failure – Columbia University Irving Medical Center, via EurekAlert (free)

 


 

#ESCCongress – Highlights from the 2018 Meeting of the European Society of Cardiology

 

 

1 – #ESCCongress – 2018 ESC/ESH Guidelines for the management of arterial hypertension – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

2 – #ESCCongress – 2018 ESC/EACTS Guidelines on myocardial revascularization – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

3 – #ESCCongress – Fourth universal definition of myocardial infarction (2018) – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

4 – #ESCCongress – 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

5 – #ESCCongress – Recommendations for participation in competitive sports of athletes with arterial hypertension: a position statement from the sports cardiology section of the European Association of Preventive Cardiology (EAPC) – European Heart Journal (free)

 

6 – #ESCCongress – Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery – New England Journal of Medicine (free for a limited period)

In moderate-to-high-risk patients undergoing cardiac surgery, six-month outcomes show that a restrictive red-cell transfusion strategy is noninferior to a liberal strategy” (via @NEJM see Tweet with Visual Abstract)

 

7 – #ESCCongress – CLARIFY: No Survival Benefit With Beta-Blockers Beyond 1 Year Post-MI in Stable CAD – TCTMD (free)

Related Study: B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction (free study and commentary)

“The problem, said Sorbets, is that there have never been large randomized trials to test the prognostic effects of beta-blockers in this patient group and instead, recommendations have been drawn from meta-analyses using data extracted from the acute MI setting or from observational studies.”

 

8 – #ESCCongress – Coronary CT Angiography and 5-Year Risk of Myocardial Infarction – New England Journal of Medicine (free for a limited period)

Commentary: Five Reasons I Don’t Believe an Imaging Test Improves Outcomes – by Dr. John Mandrola, in Medscape (free registration required)

See also an interesting Tweetorial by @AnilMakam, also suggesting caution before adopting this study results in clinical practice.

 

9 – #ESCCongress – Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus – New England Journal of Medicine (free for a limited period)

Commentaries: Bleeds and benefit with aspirin balanced in patients with diabetes and no effect on cancer – ESC Press Releases (free) AND  ASCEND: Aspirin Doesn’t Look Good for Primary CV Prevention in Diabetic Patients – TCTMD (free)

 

10 – #ESCCongress – Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Aspirin Fails to Prevent CV Events in People at ‘Moderate’ Risk of Disease: ARRIVE – TCTMD (free) AND ARRIVE: New Findings Contribute to Growing Body of Evidence Surrounding Aspirin Use – American College of Cardiology (free) AND Daily Aspirin Fails to Lower CV Risk in Long-term, Primary Prevention ARRIVE Trial – Medscape (free registration required) AND Jury still out on aspirin a day to prevent heart attack and stroke – ESC Press Releases (free)

 


 

1 – Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet (free)

Commentaries: No level of alcohol consumption improves health – The Lancet (free) AND No amount of alcohol is good for your overall health, global study says – CNN (free) AND New scientific study: no safe level of alcohol – Institute for Health Metrics and Evaluation (free)

“Alcohol was responsible for nearly 3 million deaths in 2016, the study says. It was the leading risk factor for disease and premature death in men and women between the ages of 15 and 49 worldwide in 2016, accounting for nearly one in 10 deaths.” (from @cnni see Tweet)

 

2 – Antibiotics should not be issued as first line of treatment for a cough, says NICE and PHE – NICE News and Features (free)

Commentaries: Promote honey rather than antibiotics for coughs, doctors told – The Guardian (free) AND Use honey first for a cough, new guidelines say – BBC (free)

Related: Honey for acute cough in children – Cochrane Library (free systematic review and commentary)

 

3 – How scientists are learning to predict your future with your genes – VOX (free) (via @EricTopol)

There’s not one light switch but hundreds, each with the ability to slightly increase or decrease the chances of developing the illness.”

 

4 – Perspective: Adolescents’ Use of “Pod Mod” E-Cigarettes — Urgent Concerns – New England Journal of Medicine (free)

 

5 – A Late-Life Surprise: Taking Care Of Frail, Aging Parents – Kaiser Health News (free)

 

6 – Viewpoint: The Challenge of Reforming Nutritional Epidemiologic Research – JAMA (free)

“…the emerging picture of nutritional epidemiology is difficult to reconcile with good scientific principles. The field needs radical reform.”

 

7 – Review: Difficult tracheal intubation in critically ill – Journal of Intensive Care (free)

 

8 – Glucocorticoids for croup in children – Cochrane Library (free for a limited period)

Summary: Glucocorticoids for croup in children – Cochrane Library (free)

Commentary: Glucocorticoid Therapy Examined in Pediatric Patients With Croup – MPR (free)

 

9 – Risk of Esophageal Adenocarcinoma After Antireflux Surgery in Patients With Gastroesophageal Reflux Disease in the Nordic Countries – JAMA Oncology (free for a limited period)

 

10 – Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia – JAMA (link to abstract – $ for full-text)

Commentaries: Study confirms that keeping the heart healthy also reduces dementia risk – NHS Choices (free) AND The Healthier Your Heart, the Healthier Your Brain May Be – The New York Times (10 articles per month are free) AND Cardiovascular Risk Factors Also Linked to Dementia – MedicalResearch.com (free) AND Reducing CV Risk May Improve Brain Health at Any Stage in Life, Studies Hint – TCTMD (free)

 


 

1 – Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Related articles: Screening for Cervical Cancer With High-Risk Human Papillomavirus Testing: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA (free) AND Screening for Cervical Cancer in Primary Care: A Decision Analysis for the US Preventive Services Task Force – JAMA (free)

Editorials: Screening for Cervical Cancer: New Tools and New Opportunities (free for a limited period) AND Cervical Cancer Screening—Moving From the Value of Evidence to the Evidence of Value (free for a limited period)

Author Interview: USPSTF Recommendation: Screening for Cervical Cancer (free)

Final Update Summary: Cervical Cancer: Screening – US Preventive Service Task Force (free)

Commentaries: Cervical cancer screening without Pap test OK for some women – Reuters (free) AND For Cervical Cancer Screening, Women Over 30 Can Now Choose The HPV Test Only – NPR (free) AND Annual Pap Test a ‘Thing of the Past?’ – Florida Atlantic University (free)

 

2 – Joint Consensus Document: Management of antithrombotic therapy in AF patients presenting with ACS and/or undergoing PCI – European Heart Journal (free)

 

3 – CSI position statement on management of heart failure in India – Indian Heart Journal (free)

 

4 – 2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation – World Journal of Emergency Surgery (free)

 

5 – The Japanese Clinical Practice Guideline for acute kidney injury 2016 – Journal of Intensive Care (free)

 

6 – Our first year together – World Health Organization (free)

“Delighted to share my first annual letter as WHO Director-General. It outlines our major achievements over the past year and what I believe are the keys to achieving #HealthForAll. I’m proud of everything we’ve achieved – but we’re just getting started!” (via @DrTedros see Tweet)

 

7 – How smartphones are becoming a weapon in the global fight against tuberculosis – STAT (free)

 

8 – Long-Term Association of Low-Density Lipoprotein Cholesterol With Cardiovascular Mortality in Individuals at Low 10-Year Risk of Atherosclerotic Cardiovascular Disease – Circulation (free)

Commentaries: ‘Bad’ cholesterol can be deadly in otherwise healthy people – AHA News (free) AND LDL >160 Tied to Increased Mortality in Low-Risk Patients – Physician’s First Watch (free) AND Study: Elevated LDL, non-HDL increase CVD mortality risk in young, healthy individuals – Cardiovascular Business (free) AND Moderate ‘bad cholesterol’ levels tied to early death for healthy people – Reuters (free)

 

9 – Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials – Critical Care (free)

Commentary: Procalcitonin guidance linked to improved sepsis survival – Univadis (free registration required)

 

10 – Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Pregabalin may increase the risk of death when coprescribed with opioids – 2 Minute Medicine (free) AND Pregabalin Linked To Increased Risk for Opioid-Related Deaths – MedicalResearch.com (free) AND Anticonvulsant With Opioids Tied To Higher Mortality – MedPage Today (free registration required)

 


 

1 – Podcast: #109: Things We Do For No Reason: A High Value Episode – The Curbsiders (free audio and summary)

Related Series: Choosing Wisely: Things We Do For No Reason – Journal of Hospital Medicine (some free articles)

 

2 – Perspective: Outbreaks in a Rapidly Changing Central Africa — Lessons from Ebola – New England Journal of Medicine (free)

Related: Experimental Ebola treatments OK’d in DRC as cases top 100 – CIDRAP (free) AND Congo approves more experimental Ebola treatments as cases rise – Reuters (free)

 

3 – Sport Specialization and Risk of Overuse Injuries: A Systematic Review With Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentary: Sport specialization tied to injuries in kids and teens – Reuters (free)

 

4 – Asthma and COPD Overlap in Women: Incidence and Risk Factors – Annals of the American Thoracic Society (link to abstract – $ for full-text)

Commentaries: More than 40 percent of women with asthma may develop COPD, but risk may be reduced – Annals of Thoracic Society (free) AND Four in 10 women with asthma may develop COPD – Reuters (free) AND Four in 10 women with asthma may develop COPD – OnMedica (free)

 

5 – Perspective: Exploring the Relationship Between Depression and Dementia – JAMA (free for a limited period)

 

6 – Association Between Electronic Cigarette Use and Myocardial Infarction – American Journal of Preventive Medicine (free for a limited period)

Commentary: Risk of heart attacks is double for daily e-cigarette users – University of California – San Francisco, via ScienceDaily (free)

“New analysis shows five-fold risk for people who use both cigarettes and e-cigarettes daily”

 

7 – Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) – Cochrane Library (free for a limited period)

Summary: Phosphate binders to prevent complications of chronic kidney disease – Cochrane Library (free)

 

8 – Extended antibiotic infusions could save lives: Here’s how to do it – PulmCCM (free)

Related Research: Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (free)

The simplest (and cheapest) technique is simply to reduce the time between doses.”

 

9 – Seven days of antibiotics were as good as 14 for gram-negative bacteremia – PulmCCM (free)

Related Commentary: Seven-day antibiotic course delivers similar outcomes to 14-days for Gram-negative bacteraemia – European Society of Clinical Microbiology and Infectious Diseases, via EurekAlert (free)

“It’s important to note that source control was believed to be achieved in all enrolled patients. If source control cannot be achieved (e.g., an abscess, or an infected heart valve or indwelling catheter that cannot safely be removed), prolonged antibiotic courses are often advisable.”

 

10 – Breastfeeding History and Risk of Stroke Among Parous Postmenopausal Women in the Women’s Health Initiative – Journal of the American Heart Association (free)

Commentaries: Breastfeeding linked to lower stroke risk – Reuters (free) AND Breastfeeding may help protect mothers against stroke – AHA News (free)

“…ultimately, the study is observational, which means that it can only prove that breastfeeding is associated with lower risk of stroke as opposed to being the cause of the lowered risk.” (from Reuters)

 


 

1 – Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association – Circulation (free PDF)

AHA News Release: Chagas disease, caused by a parasite, has spread outside of Latin America and carries a high risk of heart disease (free)

Top Ten Things to Know: Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management (free PDF)

 

2 – Clinical Report: The Power of Play: A Pediatric Role in Enhancing Development in Young Children – Pediatrics (free)

News Release: Want Creative, Curious, Healthier Children with 21st Century Skills? Let Them Play – American Academy of Pediatrics (free)

Commentary: It’s come to this: A checkup with the pediatrician may soon include a prescription for play – Los Angeles Times (free) AND Let Kids Play – The New York Times (10 articles per month are free) AND AAP Report Highlights Importance of Children’s Play for Development – Journal Watch (free)

 

3 – Rapid Communication: Key changes to treatment of multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) – World Health Organization (free PDF)

News Release: WHO announces landmark changes in MDR-TB treatment regimens (free)

Commentary: WHO revises MDR-TB treatment with focus on oral drugs – CIDRAP (free)

 

4 – Measles cases hit record high in the European Region – World Health Organization (free)

Commentaries: Measles cases hit record high in Europe – BBC (free) AND Expert reaction to measles cases in Europe – Science Media Centre (free) AND Low MMR uptake blamed for surge in measles cases across Europe – The Guardian (free) AND Measles cases reach record high in Europe – CNN (free)

 

5 – Assessment of the Safety of Discharging Select Patients Directly Home From the Intensive Care Unit: A Multicenter Population-Based Cohort Study – JAMA Internal Medicine (free for a limited period)

Invited Commentary: The Complexity and Challenges of Intensive Care Unit Admissions and Discharges: Similarities With All Hospitalized Patients – JAMA Internal Medicine (free for a limited period)

 

6 – Clinical Update: Management of Groin Hernias in Adults—2018 – JAMA (free for a limited period)

 

7 – Perspective: This Drug Is Safe and Effective. Wait. Compared With What? – The New York Times (10 articles per month are free)

 

8 – Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years – JAMA Pediatrics (free)

“Rotavirus-associated mortality has decreased by 48.2% in children under 5 between 1990 and 2016” (via @IHME_UW see Tweet with infographics)

 

9 – Optimising first- and second-line treatment strategies for untreated major depressive disorder — the SUND study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial – BMC Medicine (free)

 

10 – Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department – Canadian Medical Association Journal (free)

Commentaries: Simple score to diagnose heart attacks is safer, faster than current methods – McMaster University (free) AND Clinical Chemistry Score Helps Rule Out Diagnosis of Heart Attack – MedicalResearch.com (free)

 


 

1 – Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial – The Lancet (free)

Invited commentary: Helping children with hearing loss from otitis media with effusion – The Lancet (free)

“Short-course oral prednisolone is not an effective treatment for most children aged 2–8 years with persistent otitis media with effusion but is well tolerated—findings from OSTRICH, the first placebo-controlled trial” (via @TheLancet see Tweet)

 

2 – Report: E-Cigarettes – House of Commons Science and Technology Committee (free PDF)

Commentaries: Stop treating e-cigs like conventional cigarettes, MPs tell NHS – OnMedica (free) AND E-cigarettes can be key weapon against smoking, say MPs – BBC (free)

See also: related guidelines, reports and commentaries on e-cigarettes (all free)

 

3 – Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis – Critical Care Medicine (free)

Related: Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)

 

4 – Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It – The New York Times (10 articles per month are free) (via @CarlosdelRio7 see Tweet)

Related commentaries: Vitamin D Screening and Supplementation in Primary Care: Time to Curb Our Enthusiasm – American Family Physician (free) AND Your vitamin D tests and supplements are probably a waste of money – VOX (free) AND Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

Related Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (free)

“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk” (from NICE Guideline)

 

5 – Too Much Medicine: A small medical conference with a big impact – HealthNewsReview (free)

 

6 – Review: Intravenous fluid therapy in critically ill adults – Nature Reviews Nephrology (free for a limited period) (via @CritCareReviews)

 

7 – Review: Airway and ventilation management during cardiopulmonary resuscitation and after successful resuscitation – Critical Care (free)

 

8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentaries: WHO Expects Ebola To Spread In Congo In Areas Too Dangerous To Send Workers – NPR (free) AND Health worker among 5 new cases in DRC Ebola outbreak – CIDRAP (free) AND Militia threat hampers Ebola fight in Congo as disease kills 47 – Reuters (free)

 

9 – Association of Body Mass Index With Blood Pressure Among 1.7 Million Chinese Adults – JAMA Network Open (free)

Commentary: As body mass index increases, blood pressure may as well – Yale University (free)

 

10 – Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis – The Lancet Public Health (free)

Commentaries: Evolving evidence about diet and health – The Lancet Public Health (free) AND Expert reaction to study looking at carbohydrate intake and health – Science Media Centre (free) AND Moderate carbohydrate intake may be best for health, study suggests – The Lancet, via ScienceDaily (free) AND Low-carb diets could shorten life, study suggests – BBC (free)

 


 

1 – 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease (free PDF)

News Release: Societies Release Updated Guideline for Treating Adult Congenital Heart Disease Patients (free)

Key Points to Remember: 2018 AHA/ACC Guideline for Adults With Congenital Heart Disease – American College of Cardiology (free)

 

2 – Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU – Critical Care Medicine (free) (via @Abraham_RMI)

 

3 – Association of Compensation From the Surgical and Medical Device Industry to Physicians and Self-declared Conflict of Interest – JAMA Surgery (free for a limited period)

Author Interview: Association of Compensation to Physicians From Industry and Self-declared Conflict of Interest (free)

Commentaries: Safeguarding Against Conflicts of Interest in the Surgical Literature – JAMA Surgery (free for a limited period) AND Financial Ties That Bind: Studies Often Fall Short On Conflict-Of-Interest Disclosures – Kaiser Health News (free)

 

4 – Recent trends in life expectancy across high income countries: retrospective observational study – The BMJ (free)

Editorial: Reversals in life expectancy in high income countries? (free for a limited period)

Commentaries: Life Expectancy Declining Across High Income Countries – Eurasia Review (free) AND Australians living longer but life expectancy dips in US and UK – The Guardian (free) AND UK life expectancy drops while other western countries improve – NHS Choices (free)

 

5 – Changes in midlife death rates across racial and ethnic groups in the United States: systematic analysis of vital statistics – The BMJ (free)

Infographic: Why is US Life Expectancy Falling Behind? (free PDF)

Commentary: Life expectancy drops in the US and the UK, rises in Australia, a new study finds – CNN (free)

 

6 – Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD (free)

Related: Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free) AND Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

 

7 – Effect of Peer Comparison Letters for High-Volume Primary Care Prescribers of Quetiapine in Older and Disabled Adults: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Behavioral nudges lead to striking drop in prescriptions of potent antipsychotic – Columbia University’s Mailman School of Public Health, via ScienceDaily (free) AND Study Reduces Over-prescription of Antipsychotics in Older Adults – Mad in America (free) AND ‘Dear Doctor’ Letters Use Peer Pressure, Government Warning To Stop Overprescribing – NPR (free) AND Peer Pressure Tactic Successfully Curbs Overprescribing – Medscape (free registration required)

 

8 – Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality – The New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Weight gain after smoking cessation linked with increased short-term diabetes risk – Harvard T.H. Chan School of Public Health (free) AND Weight gain temporarily hikes diabetes risk when smokers quit – Reuters (free) AND Smokers Are Better Off After They Quit Even if They Gain Weight – Physician’s First Watch (free)

 

9 – Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free for a limited period)

Summary: Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free)

 

10 – Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Autism and DDT: What one million pregnancies can — and can’t — reveal – Nature News (free) AND Epidemiologists Link DDT From The 1970s To Modern Autism Diagnoses – Science 2.0 (free – skeptical point of view on study results)

 


 

1 – Risk Factors, Mortality, and Cardiovascular Outcomes in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: In Type 2 Diabetes, Five Risk Factor Targets Keep MI, Stroke, and Death in Check – TCTMD (free) AND How People With Type 2 Diabetes Can Lower Their Risk of Health Problems – TIME (free) AND T2D, Without Other Risks, Not Tied to Excess Mortality – MedPage Today (free registration required)

 

2 – Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data – The Lancet Neurology (free)

Commentary: Brain scan checklist set to boost care for stroke survivors – University of Edinburgh, via EurekAlert (free)

 

3 – Trends in Use of Daily Chest Radiographs Among US Adults Receiving Mechanical Ventilation – JAMA Network Open (free)

Commentaries: Daily Chest X-Rays Still Overused in Mechanically Ventilated Patients – MedicalResearch.com (free) AND Routine daily CXRs for ventilated patients: de-adoption is lagging – Univadis (free registration required) AND Chest x-rays overused on ventilation patients despite ACR guideline – HealthImaging (free)

 

4 – Editorial: Making diagnostic tests as essential as medicines – BMJ Global Health (free)

Related: Report: First-ever WHO List of Essential Diagnostic Tests (free report and news release) AND The WHO Essential Diagnostic List: A Tool for the Future (free commentaries)

 

5 – How Unpaywall is transforming open science – Nature News (free)

Related: Unlocking paywalled research papers (legally) (free commentaries) AND Half of papers searched for online are free to read (free)

We have been using the Unpaywall Extension for a while, and it is indeed a handy tool to find free versions (entirely legal) of paywalled articles.

 

6 – Long-Term Prognosis of Patients With Takotsubo Syndrome – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Long-Term Prognosis of Takotsubo Syndrome – American College of Cardiology (free) AND How deadly is Takotsubo syndrome? It depends on the trigger – Cardiovascular Business (free)

Related: International Expert Consensus Document on Takotsubo Syndrome (free)

 

7 – Perspective: Medical students are skipping class in droves — and making lectures increasingly obsolete – STAT (free)

 

8 – Ebola virus disease in the Democratic Republic of the Congo – Operational readiness and preparedness in neighbouring countries – World Health Organization (free)

Related: WHO chief calls for end to fighting in Congo to halt Ebola spread – The Guardian (free) AND Ebola cases mounting in DRC as region prepares for more – CIDRAP (free)

 

9 – Association Between Traumatic Brain Injury and Risk of Suicide – JAMA (link to abstract – $ for full-text)

Commentaries: Traumatic brain injury tied to increased risk of suicide – Reuters (free) AND Risk of Suicide Increases After TBI, Study Finds – Psychiatric News Alert (free) AND Expert reaction to traumatic brain injury and suicide – Science Media Centre (free)

 

10 – Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Switching Anti-Psychotic Medications Doesn’t Improve Outcomes in First-Episode Schizophrenia Patients – Mount Sinai (free) AND No Benefit of Switching Antipsychotics in Early Schizophrenia – Medscape (free registration required) AND No Gain with Antipsych Meds Switch in Schizophrenia – MedPage Today (free registration required)

 


 

1 – State of the Art Review: Overdiagnosis in primary care: framing the problem and finding solutions – The BMJ (free for two weeks)

 

2 – Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations – Nature Genetics (link to abstract – $ for full-text)

Commentaries: Researchers predict risk for common deadly diseases from millions of genetic variants – Broad Institute of MIT and Harvard, ScienceDaily (free) AND Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA – The New York Times (10 articles per month are free) AND Multi-gene test may find risk for heart disease and more – Associated Press (free) AND A Harvard Scientist Thinks He Has a Gene Test for Heart Attack Risk. He Wants to Give It Away Free – Forbes (free)

  

3 – Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Fixed-Dose Combination Pill for Hypertension Treatment in Sri Lanka (free)

Commentaries: Three-in-one pill lowers blood pressure significantly, study say – UPI (free) AND Innovative triple pill significantly lowers blood pressure, study finds – George Institute for Global Health, via EurekAlert (free)

 

4 – Richard Smith: The polypill and the long journey to major impact – The BMJ Opinion (free)

Related Reviews: Strengths and Limitations of Using the Polypill in Cardiovascular Prevention – Current Cardiology Reports (free) AND The polypill approach – An innovative strategy to improve cardiovascular health in Europe – BMC Pharmacology and Toxicology (free)

 

5 – Cancer in People Living with HIV – NCCN Clinical Practice Guidelines in Oncology – Journal of the National Cancer Center Network (free)

 

6 – Opinion: Lessons for physicians from ‘The Bleeding Edge’: If you see something, say something – STAT (free)

“…physicians must act decisively when they identify the rare outlier in their midst. To do anything less would risk our credibility. Worse still, it could risk the lives of the people we took an oath not to harm.”

 

7 – Yoga, Depression, & Clinical Trial Critique 101 – Hilda Bastian, in Absolutely Maybe Blog (free)

“5 steps to unpack a randomized trial!” (via @hildabast, see Tweet)

 

8 – DRC Ebola cases surpass earlier outbreak total, virus infects 4 more health workers – CIDRAP (free)

Related: DRC may provide model for containing future Ebola outbreaks – The Conversation (free)

 

9 – Book: Diabetes in America, 3rd Edition – National Institutes of Health (free chapters)

News Release: New NIH reference book is one-stop resource for diabetes medical information – National Institutes of Health (free)

 

10 – Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews – Cochrane Library (free)

Summary: Treatments to improve pregnancy outcomes for women who develop diabetes during pregnancy: an overview of Cochrane systematic reviews – Cochrane Library (free)

 


 

1 – Clinically applicable deep learning for diagnosis and referral in retinal disease – Nature Medicine (free for a limited period)

Commentaries: Opening the ‘black box,’ Google DeepMind AI system diagnoses eye diseases and shows its work – STAT (free) AND Artificial intelligence tool ‘as good as experts’ at detecting eye problems – The Guardian (free)

 

2 – Automated deep-neural-network surveillance of cranial images for acute neurologic events – Nature Medicine (free for a limited period)

Commentaries: Artificial Intelligence Platform Screens for Acute Neurological Illnesses at Mount Sinai – Mount Sinai Health System, via NewsWise (free) AND AI diagnoses neurological diseases on CT in 1.2 seconds – Health Imaging (free) AND New AI system can screen for neurological illnesses in seconds – UPI (free)

 

3 – Screening for Urinary Incontinence in Women: A Recommendation From the Women’s Preventive Services Initiative – Annals of Internal Medicine (free)

Commentaries: WPSI says screen all women annually for urinary incontinence – American College of Physicians, via EurekAlert (free)

 

4 – Diagnosis of Invasive Fungal Diseases in Haematology and Oncology. 2018 Update of the Recommendations of the Infectious Diseases Working Party of the German Society for Hematology and Medical Oncology (AGIHO) – Mycosis (free PDF)

 

5 – American Academy of Family Physicians: Twenty Things Physicians and Patients Should Question (free)

Commentary: Choosing Wisely: New Practices to Avoid in Family Medicine – NEJM Journal Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

6 – Analysis of clinical benefit, harms, and cost-effectiveness of screening women for abdominal aortic aneurysm – The Lancet (free)

Commentaries: Should we screen women for abdominal aortic aneurysm? – The Lancet (free) AND Cost-Effectiveness of Screening Women for AAA – American College of Cardiology (free) AND Women Likely Not Good Targets for AAA Screening, Study Suggests – TCTMD (free)

 

7 – Prevalence and Estimated Economic Burden of Substandard and Falsified Medicines in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: Prevalence of Substandard and Falsified Essential Medicines: Still an Incomplete Picture – JAMA Network Open (free) AND New Study Finds Fake, Low-Quality Medicines Prevalent in the Developing World – University of North Carolina at Chapel Hill, via R&D (free)

 

8 – Evaluating Shared Decision Making for Lung Cancer Screening – JAMA Internal Medicine (free for a limited period)

Editorial: Failing Grade for Shared Decision Making for Lung Cancer Screening (free for a limited period)

Author Interview: Evaluating Shared Decision Making for Lung Cancer Screening (free audio)

Commentaries: Doctors may not explain pros, cons of lung cancer screening – Reuters (free) AND Shared Decision-Making Flops for Lung Ca Screening – MedPage Today (free registration required)

 

9 – Perspective: Surrogate End Points Ain’t all that Bad – The Health Care Blog (free) (via @RogueRad)

 

10 – Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Early type 1 diabetes shortens women’s lives by 18 years – University of Gothenburg, via ScienceDaily (free) AND Early age type 1 diabetes linked to shorter life expectancy than later age diagnosis – OnMedica (free)

 


 

1 – Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)

 

2 – Outbreaks: Behind the headlines – World Health Organization (free)

 

3 – Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction – JAMA Network Open (free)

Commentaries: Algorithm IDs Patients at Risk of Post-MI Events – MedPage Today (free registration required) AND Risk Model Helps Predict CV Events 1 Year After Acute MI – Medscape (free registration required)

 

4 – Analysis: Renaming low risk conditions labelled as cancer – The BMJ (free for a limited period)

Commentaries: Is it time to remove the cancer label from low-risk conditions? – The Conversation (free) AND Doctors should avoid saying ‘cancer’ for minor lesions – study – The Guardian (free) Drop ‘cancer’ label to protect patients from over-treatment, researchers say – The Sidney Morning Herald (free)

 

5 – Review: Dos and Don’ts in the Management of Cirrhosis: A View from the 21st Century – American Journal of Gastroenterology (via @Abraham_RMI)

 

6 – The multivitamin industry rakes in billions of dollars. But science says we’re not getting healthier – by Timothy Caulfield, in NBC News THINK (free)

Related Study: Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free) AND Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)

“Unless you have a clinically identified deficiency, the research tells us there is little reason to consume supplements.”

 

7 – Tick- and Mosquito-Borne Diseases Are Increasing Dramatically – Scientific American (free)

Related: CDC Report: U.S Trends in Vector-borne Diseases (link to report and commentaries)

 

8 – Infographic: High burden, low budget: non-communicable diseases in low- and middle-income countries – Institute for Health Metrics and Evaluation (free) (via @equitylist)

 

9 – Multifactorial and multiple component interventions for preventing falls in older people living in the community – Cochrane Library (free)

Summary: Featured Review: Multifactorial and multiple component interventions for preventing falls in older people living in the community – Cochrane Library (free)

 

10 – Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016 – Kidney International (free)

News release and visual abstract: KI article shows the doubling incidence, prevalence and mortality of CKD – International Society of Nephrology (free)

Commentary: Global Burden of Kidney Disease on the Rise, Unequally Distributed – Medscape (free registration required)

 


 

1 – Dietary Diversity: Implications for Obesity Prevention in Adult Populations: A Science Advisory From the American Heart Association – Circulation (free PDF)

News Release: A diverse diet may not be the healthiest one (free)

Commentary: Diet Recommendations for Obesity Prevention: Time to Ditch Diversity (free)

Top Ten Things to Know: Dietary Diversity: Implications for Obesity Prevention in Adult Populations (free PDF)

 

2 – Opioid prescribing decreases after learning of a patient’s fatal overdose – Science (free for a limited period)

Commentary: Notification of patient overdose deaths reduces clinician opioid prescriptions – NIH News Releases (free) AND Clinicians were told their patient had died of an overdose. Then opioid prescribing dropped – STAT (free)

 

3 – Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis – The Lancet Psychiatry (free)

Commentaries: Refining treatment choices for ADHD – The Lancet Psychiatry (free) AND ADHD medications: Of all available drugs, methylphenidate should be first option for short-term treatment in children – ScienceDaily (free) AND Analysis of ADHD Drugs: Use Methylphenidate in Kids, Amphetamines in Adults – Physician’s First Watch (free)

Related: Cochrane Review: Adverse Events of Methylphenidate for ADHD in Children and Adolescents (link to abstract and free summary) AND Short Review: Stimulants for ADHD in children (free) AND Opinion: Drug treatment of ADHD – tenuous scientific basis (free)

 

4 – Viewpoint: Clinical Practice Guidelines: What’s Next? – JAMA (free for a limited period)

 

5 – Urinary sodium excretion, blood pressure, cardiovascular disease, and mortality: a community-level prospective epidemiological cohort study – The Lancet (link to abstract – $ for full-text)

Commentary: Lancet Paper Adds To Evidence That Reducing Salt To Very Low Levels May Be Dangerous – CardioBrief (free)

Related Report: Salt intake and Cardiovascular Disease (free report and commentaries)

 

6 – Are the “Best Buys” for Alcohol Control Still Valid? An Update on the Comparative Cost-Effectiveness of Alcohol Control Strategies at the Global Level – Journal of Studies on Alcohol and Drugs (free)

Commentary: Higher alcohol taxes are cost-effective in reducing alcohol harms – ScienceDaily (free)

Related: To improve global health, tax the things that are killing us – Financial Times (free policies, articles and commentaries) AND Policy lessons from health taxes (free research and commentaries)

 

7 – Nonsurgical Treatments for Urinary Incontinence in Women: A Systematic Review Update – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF)

 

8 – Scaled deployment of Wolbachia to protect the community from Aedes transmitted arboviruses – Gates Open Research (free)

Commentary: Dengue rates plummet in Australian city after release of modified mosquitoes – Nature News (free)

 

9 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: DRC probes more suspected Ebola cases, rules out 3 – CIDRAP (free) AND War zone complicates roll-out of Ebola vaccine in latest outbreak – Nature News (free)

 

10 – Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: How common is endometrial cancer in women with postmenopausal bleeding? – eCancer News (free) AND Postmenopausal Bleeding: Reliable Sign of Endometrial Cancer – Medscape (free registration required)

 


 

1 – Practice guideline update recommendations summary: Disorders of consciousness – American Academy of Neurology (free PDF)

Related: Ethical, palliative, and policy considerations in disorders of consciousness – Neurology (free PDF) AND Comprehensive systematic review update summary: Disorders of consciousness – Neurology (free PDF)

Commentaries: New Guideline Released for Managing Vegetative and Minimally Conscious States – American Academy of Neurology, via NewsWise (free) AND Groups Issue New Disorders of Consciousness Guidelines – MedPage Today (free registration required)

 

2 – Labor Induction versus Expectant Management in Low-Risk Nulliparous Women – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Labor Induction versus Expectant Management in Low-Risk Women (free)

Commentaries: Induced labor at 39 weeks may reduce likelihood of C-section, NIH study suggests – NIH News Releases (free) AND Pregnancy Debate Revisited: To Induce Labor, Or Not? – NPR (free)

 

3 – Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth – New England Journal of Medicine (free)

Commentary: Maternal Vitamin D Supplementation Doesn’t Improve Infant Growth – Physician’s First Watch (free)

 

4 – Outcomes of Cardiac Screening in Adolescent Soccer Players – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Footballer heart death risk ‘underestimated’ – BBC (free) AND No Easy Answers on Best Heart Check-Up for Young Athletes – Associated Press, via NYT (free)

 

5 – Would technology enabled remote consulting save time and add value in primary care? – The BMJ Opinion (free)

“Would remote consulting save time and add value in primary care? Rising multimorbidity makes the evaluation of potentially time saving technologies ever more necessary” (via @bmj_latest see Tweet)

 

6 – Treatment for Bipolar Disorder in Adults: A Systematic Review – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF) AND Evidence Summary (free PDF)

 

7 – WHO MERS Global Summary and Assessment of Risk – World Health Organization (free PDF)

Commentary: WHO highlights ongoing hospital MERS outbreak threat – CIDRAP (free)

 

8 – Perspective: Addressing Barriers to Inclusion of Pregnant Women in Clinical Trials – JAMA (free for a limited period)

 

9 – Publication bias: The answer to your research question may be sitting in somebody’s file drawer – Students 4 Best Evidence (free)

Related: Bias in medical research: A glossary of common research biases – First10Em (free) Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

 

10 – Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Expert reaction to physical activity linked to improved mental health – Science Media Centre (free) AND Regular exercise ‘best for mental health’ – BBC (free) AND Exercise is good for your body and your mind, study says – CNN (free)

 


 

1 – Screening for Atrial Fibrillation With Electrocardiography: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Atrial Fibrillation Comes With Many Snags (free for a limited period) AND Electrocardiography Screening for Atrial Fibrillation: We Can Do Better (free for a limited period)

Author Interview: USPSTF Recommendation: Screening for Atrial Fibrillation With Electrocardiography (free audio)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for atrial fibrillation with ECG. (I statement)”

 

2 – Mortality effects of timing alternatives for hip fracture surgery – Canadian Medical Association Journal (free)

Commentaries: Lower death rate when senior hip fractures are repaired quickly – Reuters (free) AND Delayed surgery for hip fractures cause of preventable deaths, study finds – The Globe and Mail (free) AND The sun should not set twice before hip fracture repair – CMAJ, via ScienceDaily (free)

 

3 – Update: Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Men with Possible Zika Virus Exposure — United States, August 2018 – CDC, MMWR (free)

Related: Vital Signs: Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018 – CDC, MMWR (free)

Commentaries: 1 in 7 kids exposed to Zika in utero suffers defects, delays – CIDRAP (free) AND 1 in 7 babies exposed to Zika in the womb have health problems, CDC reports – STAT (free) AND One in 7 babies prenatally exposed to Zika has health problems, CDC says – CNN (free)

 

4 – Corticosteroid use and intensive care unit-acquired weakness: a systematic review and meta-analysis – Critical Care (free)

 

5 – The use of viscoelastic haemostatic assays in the management of major bleeding: A British Society for Haematology Guideline – British Journal of Haematology (free)

Source: Critical Care Reviews Newsletter

 

6 – Perspective: Workplace Wellness Programs Don’t Work Well. Why Some Studies Show Otherwise. – The New York Times (10 articles per month are free)

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: July 2018 – eCancer News (free)

 

8 – Cardiotoxicity and Cardiac Monitoring Among Chemotherapy-Treated Breast Cancer Patients – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentaries: Prioritize cardiac monitoring for high-risk breast cancer patients, study suggests – ACP Internist (free) AND Cardiac monitoring may benefit high-risk breast cancer patients against heart failure – Cardiovascular Business (free) AND After Cardiotoxic Chemo, Less Than Half of Women With Breast Cancer Get Recommended Monitoring – TCTMD (free) AND Study Shows Importance of Cardiac Monitoring in High-Risk Breast Cancer Patients – American College of Cardiology (free)

 

9 – Special Issue: Roles of Physicians in Healthy Dying- AMA Journal of Ethics (free articles)

“What the roles of clinicians and patients should be in defining what constitutes a quality dying experience and good care of dying people has received less attention than issues like euthanasia and assisted death. Which parts of dying, if any, should be medicalized and why? What do patients and clinicians need to know about dying and why? The August 2018 issue of the AMA Journal of Ethics explores these and other questions.”

 

10 – Twelve-Month Outcomes After Transplant of Hepatitis C–Infected Kidneys Into Uninfected Recipients: A Single-Group Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Patients who accepted infected kidneys cured of hepatitis C – STAT (free) AND Good Outcomes for HCV-Negative Recipients of HCV Kidneys – Renal & Urology News (free)

 


 

1 – Sedentary Behaviors in Today’s Youth: Approaches to the Prevention and Management of Childhood Obesity: A Scientific Statement From the American Heart Association – Circulation (free PDF)

News release: New tools, old rules: limit screen-based recreational media at home – AHA/ASA Newsroom (free)

 

2 – Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases – Hepatology (free)

 

3 – AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2018 – German Gynecological Oncology Group (free)

 

4 – AGO Recommendations for the Diagnosis and Treatment of Patients with Advanced and Metastatic Breast Cancer: Update 2018 – German Gynecological Oncology Group (free)

 

5 – Patient–physician gender concordance and increased mortality among female heart attack patients – PNAS (link to abstract – $ for full-text)

Commentaries: Women More Likely to Survive Heart Attacks If Treated by Female Doctors – The Atlantic (free) AND Women survive a heart attack more often when their doctor is female, study finds – STAT (free) AND Women survive heart attacks better with women doctors – Washington University in St. Louis, via ScienceDaily (free)

 

6 – Review: Oxygen Treatment in Intensive Care and Emergency Medicine – Deutsches Ärzteblatt International (free)

 

7 – Review: Liver enzymes: No trivial elevations, even if asymptomatic – Cleveland Clinic Journal of Medicine (free)

 

8 – Opinion: Anti-Vaccine Activists Have Taken Vaccine Science Hostage – The New York Times (10 articles per month are free)

“Should researchers not publish findings when there’s a chance they might be misinterpreted and scare the public?” (via @NYTHealth see Tweet)

 

9 – Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews – Cochrane Library (link to abstract – $ for full-text)

Summary: An overview of Cochrane Reviews on red blood cell transfusions to treat or prevent sickle cell disease-related complications – Cochrane Library (free)

 

10 – Microvascular Outcomes in Patients With Diabetes After Bariatric Surgery Versus Usual Care: A Matched Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Bariatric Surgery for Diabetes May Halve the Risk for Microvascular Disease – NEJM Physician’s First Watch (free) AND Bariatric surgery linked to significant reduction in microvascular complications of type 2 diabetes – MedicalXpress (free)

 


 

1 – Delirium in adult cancer patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

2 – Comparison of Clinical Outcomes Among Patients With Atrial Fibrillation or Atrial Flutter Stratified by CHA2DS2-VASc Score – JAMA Network Open (free)

Commentaries: Ischemic Stroke Risk Scoring May Not Be Accurate for Patients with Atrial Flutter – TCTMD (free) AND Don’t Group Afib, Atrial Flutter Together in Evaluating Stroke Risk – MedPage Today (free registration required)

 

3 – The Surviving Sepsis Campaign: A Rush to Judgment – NEJM Journal Watch (free)

Original Guideline: The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)

Related Opinion: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free)

 

4 – Playing Doctor with Watson: Medical Applications Expose Current Limits of AI – Spiegel (free) (via @EricTopol)

“IBM has big plans for how its Watson artificial intelligence software could change the medical industry. But a number of hospitals have ended their experiments with the platform, arguing that it doesn’t help diagnose or treat diseases.”

 

5 – Bias in medical research: A glossary of common research biases – First10Em (free) (via @pash22)

Related: Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

 

6 – The Illness Is Bad Enough. The Hospital May Be Even Worse – The New York Times (10 articles per month are free)

Related: Post-Hospital Syndrome — An Acquired, Transient Condition of Generalized Risk – New England Journal of Medicine (free) AND Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? – Journal of Hospital Medicine (free) (via @hmkyale)

“The elderly are particularly vulnerable to “post-hospital syndrome,” some experts believe, and that may be why so many patients return.”

 

7 – Quantifying excess deaths related to heatwaves under climate change scenarios: A multicountry time series modelling study – PLOS Medicine (free)

Commentaries: Heatwave deaths will rise steadily by 2080 as globe warms up – Monash University, via ScienceDaily (free) AND Heatwave deaths likely to rise steadily by 2080 without appropriate climate and health policies – London School of Hygiene & Tropical Medicine (free)

Related Lancet Editorial: Heatwaves and health (free)

Related Report: Lancet Countdown: Traking Progress on Health and Climate Change (free report, commentaries, infographics, video and other resources)

 

8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: Conflict in new Ebola zone of DR Congo exacerbates complexity of response: WHO emergency response chief – UN News (free) AND WHO: Ebola DRC outbreak taking place in ‘war zone’ – CIDRAP (free) AND Ebola In A Conflict Zone – NPR (free) AND WHO sees complex vaccine and security questions in Ebola response – Reuters (free)

 

9 – Colloids versus crystalloids for fluid resuscitation in critically ill people – Cochrane Library (link to abstract – $ for full-text)

Summary: Colloids or crystalloids for fluid replacement in critically people – Cochrane Library (free)

Using starches, dextrans, albumin or FFP (moderate-certainty evidence), or gelatins (low-certainty evidence), versus crystalloids probably makes little or no difference to mortality. Starches probably slightly increase the need for blood transfusion and RRT (moderate-certainty evidence), and albumin or FFP may make little or no difference to the need for renal replacement therapy (low-certainty evidence)”.

 

10 – Peer-supported self-management for people discharged from a mental health crisis team: a randomised controlled trial – The Lancet (free)

Commentaries: Peer-delivered self-management programmes in mental health – The Lancet (free) AND After the crisis: self-management and peer-support – The Mental Elf (free) AND Peer Support Helps Reduce Mental Crisis Readmissions – MedPage Today (free registration required)

 


 

1 – National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the management of heart failure 2018 – The Medical Journal of Australia (free for 10 days)

 

2 – National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the diagnosis and management of atrial fibrillation 2018 – The Medical Journal of Australia (free for 10 days)

 

3 – Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics – Italian Journal of Pediatrics (free)

 

4 – The Top 10 Pulmonary Pearls for Primary Care Physicians – Mayo Clinic Proceedings (free for a limited period)

 

5 – Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence – Mayo Clinic Proceedings (free for a limited period)

Commentaries: Regular sauna users may have fewer chronic diseases – Reuters (free) AND Saunas Linked to Numerous Health Benefits – Medscape (free registration required) AND Frequent sauna bathing has many health benefits – Elsevier, via ScienceDaily (free)

 

6 – No proof that moderate drinking prevents dementia – NHS Choices (free)

See original study: Alcohol consumption and risk of dementia (free text, editorial and commentaries)

“”Middle aged drinking may reduce dementia risk, new study finds,” is the misleading and irresponsible headline in The Daily Telegraph.”

 

7 – Viewpoint: Lyme Disease in 2018: What Is New (and What Is Not) – JAMA (free for a limited period)

 

8 – ACG Clinical Guideline: Management of Crohn’s Disease in Adults – The American Journal of Gastroenterology (free)

Commentary: New Crohn Disease Management Guidelines: Top Five Takeaways – Medscape (free registration required)

 

9 – Obesity Increases the Duration of Influenza A Virus Shedding in Adults – The Journal of Infectious Diseases (free)

Commentaries: Study suggests obesity may increase flu spread – CIDRAP (free) AND Beyond Disease Severity: The Impact of Obesity on Influenza A Virus Shedding – The Journal of Infectious Diseases (free) AND Study suggests obesity may also impact flu transmission, not just severity of illness – Infectious Diseases Society of America, via EurekAlert (free) AND Obesity extends duration of influenza A virus shedding – NIH News (free)

 

10 – Increasing tolerance of hospital Enterococcus faecium to handwash alcohols – Science Translational Medicine (link to abstract – $ for full-text)

Commentaries: Study finds increased alcohol tolerance in common hospital pathogen – CIDRAP (free) AND Superbugs now also becoming resistant to alcohol disinfectants – Reuters (free) AND Some Bacteria Are Becoming ‘More Tolerant’ Of Hand Sanitizers, Study Finds – NPR (free)

Researchers found that E faecium isolates collected in 2 Australian hospitals after 2009 were 10x more tolerant to alcohol than those collected before 2004, and that the date of isolation was a much better predictor of survival than the genotype” (via @CIDRAP_ASP see Tweet)

 


 

1 – Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults – New England Journal of Medicine (free)

Related Article: Safety and Side Effects of Rifampin versus Isoniazid in Children – New England Journal of Medicine (free)

Quick Take Video Summary: Rifampin or Isoniazid for Latent Tuberculosis (free)

Commentaries: New tuberculosis treatment could help tackle global epidemic – The Guardian (free) AND Rifampin Promising for Latent TB in Phase 3 Trials – Medscape (free registration required)

 

2 – Clinical Report: Physician’s Role in Coordinating Care of Hospitalized Children – American Academy of Pediatrics (free)

News Release: Report guides pediatricians in improving care coordination of hospitalized children – AAP News (free)

 

3 – Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Validation of ESC 0/1-h Algorithm for MI – American College of Cardiology (free) AND ESC Algorithm Safely Rules Out NSTEMI, But Caution May Be Warranted in the US – TCTMD (free)

Related Review: High-Sensitivity Cardiac Troponin in the Evaluation of Possible AMI – American College of Cardiology (free)

 

4 – Prospective Randomized Evaluation of Preoperative Angiotensin-Converting Enzyme Inhibition (PREOP-ACEI) – Journal of Hospital Medicine (free)

Commentary: Omitting ACE inhibitor before surgery reduced intraoperative hypotension, study finds – ACP Hospitalist (free)

 

5 – Cluster of presumptive Ebola cases in North Kivu in the Democratic Republic of the Congo – World Health Organization (free)

Commentaries: New Ebola outbreak declared in DRC a week after earlier one declared over – STAT (free) AND DRC confirms new Ebola cluster days after outbreak declared over – CIDRAP (free) AND Congo declares new Ebola outbreak in eastern province – Reuters (free) AND Deadly Ebola Strikes Anew, a Week After Previous Outbreak Was Extinguished – The New York Times (10 articles per month are free)

 

6 – Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline – Neurology (link to abstract – $ for full-text)

Commentary: People who frequently feel dizzy on standing ‘at future risk of dementia’ – NHS Choices (free)

Related Research: Orthostatic hypotension and symptomatic subclinical orthostatic hypotension increase risk of cognitive impairment: an integrated evidence review and analysis of a large older adult hypertensive cohort – European Heart Journal (free)

 

7 – A Consensus Statement on acromegaly therapeutic outcomes – Nature Reviews Endocrinology (free)

Commentary: Consensus statement: optimizing acromegaly management – Univadis (free registration required)

 

8 – Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study – The BMJ (free)

Editorial: Relation between alcohol consumption in midlife and dementia in late life (free)

Commentaries: Expert reaction to long term abstinence and heavy drinking associated with dementia – Science Media Centre (free) AND Middle-aged non-drinkers may have ‘higher risk’ of dementia – The Guardian (free)

 

9 – Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis – JAMA Cardiology (free for a limited period)

Author Interview: Efficacy and Safety of Further Lowering of LDL Cholesterol in Patients Starting With Very Low Levels (free)

 

10 – MRI-defined White Matter Microstructural Alteration Associated with Soccer Heading Is More Extensive in Women than Men – Radiology (free for a limited period)

Commentaries: Soccer Heading May Be Riskier for Female Players – RSNA (free) AND Heading May Be Riskier For Female Soccer Players Than Males – NPR (free)

 


 

1 – Report: Capture the moment – Early initiation of breastfeeding: the best start for every newborn – World Health Organization (free)

News Release: 3 in 5 babies not breastfed in the first hour of life (free)

Commentaries: When it comes to breastfeeding, ‘timing is everything’ in saving newborn lives – UNICEF chief – UN News (free) AND 60% of babies ‘at risk due to breastfeeding delay after birth’ – The Guardian (free)

 

2 – Evidence Synopsis: Aspirin Plus Clopidogrel vs Aspirin Alone for Preventing Cardiovascular Events Among Patients at High Risk for Cardiovascular Events – JAMA (free for a limited period)

“Clopidogrel+ASA: Reduced risk for MI and ischemic stroke – Increased risk for major bleeding compared with aspirin alone. Combined therapy is NOT associated with lower mortality.” (via @ehlJAMA see Tweet)

 

3 – Risk factors associated with revision for prosthetic joint infection after hip replacement: a prospective observational cohort study – The Lancet Infectious Diseases (free)

Commentaries: Risk factors in septic revisions following total hip arthroplasty – The Lancet Infectious Diseases (free) AND Several factors associated with hip replacement revision due to prosthetic joint infection – ACP Internist Weekly (free)

 

4 – Choosing Wisely: Society for the Advancement of Blood Management: Five Things Physicians and Patients Should Question (free)

Commentary: Choosing Wisely: Five Anemia, Transfusion Practices to Avoid – Physician’s First Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

5 – Perspective: Europe Expanded the “No Elsevier Deal” Zone & This Could Change Everything – Hilda Bastian, in Absolutely Maybe Blog (free)

 

6 – Perspective: Assisted suicide is controversial, but palliative sedation is legal and offers peace – The Washington Post (free)

 

7 – Perspective: A Fear of Lawsuits Really Does Seem to Result in Extra Medical Tests – The New York Times (10 articles per month are free)

“Doctors are known for complaining about how the malpractice system adds costs. But it has been hard to prove, until now.”

 

8 – Review: Differential diagnosis, investigation and therapy of bilateral adrenal incidentalomas – European Journal of Endocrinology (free)

 

9 – Antithrombotic Therapy in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Undergoing Percutaneous Coronary Intervention – Circulation (free)

Commentary: New Consensus Statement: NOAC and Clopidogrel for Most A-fib Patients Treated With PCI – TCTMD (free)

 

10 – Association of Statin Exposure With Histologically Confirmed Idiopathic Inflammatory Myositis in an Australian Population – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Rare Inflammatory Muscle Inflammation Increased With Statin Exposure – MedicalResearch.com (free) AND Statin Associated with an Increase in Inflammatory Myopathy – RheumNow (free) AND Statin use may increase risk for idiopathic inflammatory myositis – Healio (free registration required)

 


 

1 – Low-Calorie Sweetened Beverages and Cardiometabolic Health: A Science Advisory From the American Heart Association – Circulation (free PDF)

News Release: Limit low-calorie sodas and drinks, and stick to water instead, researchers advise (free)

 

2 – Health Collection: Strategic review of child health – The BMJ (free articles)

“About 5.6m children died before their 5th birthday in 2016. The new global child health collection launching today explores how we can work together to safeguard the health and wellbeing of children across the world.”

 

3 – Guideline: PSA-Based Prostate Cancer Screening in Men Aged 55-69 – American Academy of Family Physicians (free)

News Release: AAFP Updates Its PSA Screening Recommendation (free)

Related Guidelines with conflicting viewpoints: American Cancer Society Guideline for the Early Detection of Prostate Cancer (free) AND USPSTF Recommendation Statement: Screening for Prostate Cancer (free guideline, editorial and commentaries)

 

4 – The association between suicide deaths and putatively harmful and protective factors in media reports – Canadian Medical Association Journal (free) (via @IrfanDhalla)

Invited Commentary: Responsible reporting to prevent suicide contagion (free for one week)

 

5 – Richard Lehman’s journal reviews, 30 July 2018 – The BMJ Opinion (free)

Richard Lehman’s final review of the latest research in the top medical journals.

 

6 – Viewpoint: Gaps in the Clinical Management of Influenza: A Century Since the 1918 Pandemic – JAMA (free)

 

7 – Counseling in Pediatric Populations at Risk for Infertility and/or Sexual Function Concerns – Pediatrics (free)

News Release: How and when to counsel at-risk patients about fertility preservation, sexual function – AAP News (free)

 

8 – Drinking or Smoking While Breastfeeding and Later Cognition in Children – Pediatrics (free)

Commentaries: Study: Drinking while breastfeeding linked with children’s reasoning deficits – AAP News (free) AND Alcohol in breast milk may lead to lower cognition in kids, study finds – CNN (free) AND Fuel For Mommy Shaming: Breastfeeding And Alcohol Study Deeply Misleading – Forbes (free)

 

9 – LOw dose MAGnesium sulfate versus HIgh dose in the early management of rapid atrial fibrillation: randomised controlled double blind study – Academic Emergency Medicine (link to abstract – $ for full-text)

Commentaries: Low-dose vs. High-dose Magnesium in Rapid Afib – The PharmERToxGuy (free) AND Magnesium to treat rapid Afib in the ED – Univadis (free registration required)

 

10 – A Systematic Review and Meta‐analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department – Academic Emergency Medicine (link to abstract – $ for full-text)

Commentaries: Low-Dose Ketamine Offers Effective Alternative to Opioids in Treatment of Acute Pain, Meta-Analysis Suggests – Psychiatric News Alert (free) AND Ketamine vs Opioids for Acute Pain in the Emergency Department – MedicalResearch.com (free) AND Low-Dose Ketamine May Be a Safe Opioid Alternative, Review Confirms – Medscape (free registration required) AND Ketamine could help reduce opioid use in the ER – Medical News Today (free)

 


 

1 – Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection – World Health Organization (free)

See also: World Hepatitis Day (28 July 2018) – World Health Organization (free manuals, guidelines and campaign resources)

 

2 – Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

3 – Analysis of clinical benefit, harms, and cost-effectiveness of screening women for abdominal aortic aneurysm – The Lancet (free)

Invited Commentary: Should we screen women for abdominal aortic aneurysm? – The Lancet (free)

 

4 – Esomeprazole and aspirin in Barrett’s oesophagus (AspECT): a randomised factorial trial – The Lancet (free)

Invited Commentary: Should aspirin and PPIs be recommended for patients with Barrett’s oesophagus? – The Lancet (free)

 

5 – Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Treating Depression May Improve Cardiac Outcomes, Research Finds – AJMC (free) AND Treating depression may prevent repeat heart attack, study says – UPI (free)

 

6 – Opinion: How Do You Want to Die? – The New York Times (10 articles per month are free)

“Are we turning sudden cardiac death into a longer, winding path? Defibrillators can prevent sudden death but they also can take away the sudden-death option.” (via @RasoiniR see Tweet)

 

7 – Treatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)

Summary: Treatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)

 

8 – Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Protease inhibitors may increase risk of death in people with HIV and heart failure – OnMedica (free) AND Protease inhibitors may increase risk of death in people with HIV and heart failure – Massachusetts General Hospital, via EurekAlert (free)

 

9 – Prevalence of Depression Among Fathers at the Pediatric Well-Child Care Visit – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: New dads need depression screening, too – Reuters (free) AND New Dads as Likely to Suffer From Depression as Moms, Study Suggests – Medscape (free registration required)

 

10 – Pharmacological Treatment of Arterial Hypertension in Children and Adolescents: A Network Meta-Analysis – Hypertension (free)

Commentary: Pediatric hypertension: ACEi/ARBs look like the best choice – Univadis (free)

According to the present analysis, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers could represent the best choice as antihypertensive treatment for pediatric hypertension. However, because of the paucity of available data for the other classes of antihypertensive drugs, definitive conclusions are not allowed and further randomized controlled trials are warranted.”

 


 

1 – Medications that reduce emergency hospital admissions: an overview of systematic reviews and prioritisation of treatments – BMC Medicine (free) (via @OxPrimaryCare)

Commentary: The eleven best medications for reducing pressure on emergency care services – University of Oxford (free)

 

2 – First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (PANLAR) – Annals of Rheumatic Diseases (free) (via @Abraham_RMI)

Commentary: Latin American Clinical Practice Guidelines for Lupus – RheumNow (free)

Related Guideline: The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND Executive Summary (free)

 

3 – Fluid therapy in the emergency department: an expert practice review – Emergency Medicine Journal (free)

Related Guidelines: Intravenous fluid therapy in adults in hospital – National Institute for Health and Care Excellence (free) AND Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany – European Journal of Anaesthesiology (free)

Related Reviews: Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy – Annals of Intensive Care (free) AND A rational approach to fluid therapy in sepsis – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter

 

4 – Timing of intervention in aortic stenosis: a review of current and future strategies – Heart (free)

 

5 – Intensive blood pressure control and ‘dementia’: another mad rush to report incomplete SPRINT findings – HealthNewsReview (free)

See also: No, A Big NIH Trial Did Not Show That Lowering Blood Pressure Will Prevent Dementia – Cardiobrief (free)

 

6 – Opinion: Physicians aren’t ‘burning out.’ They’re suffering from moral injury – STAT (free)

Related: The Burnout Crisis in American Medicine (free commentaries on the subject) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and free commentaries)

 

7 – Choosing Wisely: American Academy of Pediatrics – Section on Nephrology and the American Society of Pediatric Nephrology: Five Things Physicians and Patients Should Question (free)

AAP News Release: Choosing Wisely Offers Advice on Appropriate Nephrology Testing in Children (free)

Commentary: AAP offers guidance on pediatric nephrology tests, procedures – Univadis (free registration required)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

8 – Mirror therapy for improving motor function after stroke – Cochrane Library (link to abstract – $ for full-text)

Summary: Mirror therapy for improving movement after stroke – Cochrane Library (free)

 

9 – Association of Osteoporosis Medication Use After Hip Fracture With Prevention of Subsequent Nonvertebral Fractures: An Instrumental Variable Analysis – JAMA Network Open (free)

Commentaries: Osteoporosis Treatment After Hip Fracture: Bad News and Getting Worse – JAMA Network Open (free) AND Rate of Osteoporosis Drug Treatment to Prevent Recurrent Fractures Dropping – AJMC (free) AND Osteoporosis treatment often not started after hip fracture in elderly patients, study finds – ACP Internist (free)

 

10 – Is the consumption of fast foods associated with asthma or other allergic diseases? – Respirology (free)

Commentary: Consumption of Fast Food Linked with Asthma and Other Allergic Diseases – Wiley (free) AND Study Links Fast Food Consumption to Severe Asthma – AJMC (free)

 


 

1 – UNDETECTABLE = UNTRANSMITTABLE: Public Health and HIV Viral Load Suppression – UNAIDS Explainer (free PDF)

News Release: Undetectable = Untransmittable – UNAIDS (free)

Related: Science Validates Undetectable = Untransmittable HIV Prevention Message – National Institute of Allergy and Infectious Diseases (free) AND The “Undetectable = Untransmittable” message goes global: I=I, N=N and B=B – Aidsmap (free)

 

2 – Rapid Recommendations: Patent foramen ovale closure, antiplatelet therapy or anticoagulation therapy alone for management of cryptogenic stroke? A clinical practice guideline – The BMJ (free)

 

3 – Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline – British Journal of Sports Medicine (free)

 

4 – Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Giving Plasma to Trauma Patients with Severe Bleeding During Air Transport Saves Lives – Health Sciences at the University of Pittsburgh, via NewsWise (free)

 

5 – EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis – Journal of Hepatology (free)

Source: Critical Care Reviews Newsletter

 

6 – Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF)

 

7 – Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF) AND Evidence Summary (free PDF)

 

8 – Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands – JNCI: Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentary: Pediatric CT Scans and Subsequent Malignancy Risk – The ASCO Post (free)

 

9 – Sexual transmission of Zika virus and other flaviviruses: A living systematic review – PLOS Medicine (free) (via @NIAIDNews)

Commentary: Study suggests smaller window for Zika sexual transmission – CIDRAP (free)

 

10 – Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis – JAMA (link to abstract – $ for full-text)

Commentaries: Pediatric sepsis care within an hour increases chances of survival, shows study – News Medical (free) AND “Rory’s Regulations” Improves Pediatric Sepsis Care – MedicalResearch.com (free) AND Sepsis Survival Higher in Kids With Quick Bundle Completion – Medscape (free registration required)

 


 

1 – Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2018 Recommendations of the International Antiviral Society–USA Panel – JAMA (free)

Editorial: 2018 IAS-USA Recommendations for the Use of Antiretroviral Therapy for HIV: Building on Decades of Progress (free)

Commentary: International Organization Releases New Guidelines for Treatment and Prevention of HIV Infection in Adults – University of Alabama at Birmingham, via NewsWise (free)

 

2 – Clinical Review Audio: Working on the Precipice: On the Frontlines of the AIDS Epidemic at the CDC, Part I – JAMA (free)

Related Perspective: Anthony Fauci, MD: Working to End HIV/AIDS – JAMA (free)

 

3 – Recommendations for participation in leisure time or competitive sports in athletes-patients with coronary artery disease: a position statement from the Sports Cardiology Section of the European Association of Preventive Cardiology (EAPC) – European Heart Journal (free)

 

4 – A Clinician’s Guide for Trending Cardiovascular Nutrition Controversies: Part II – Journal of the American College of Cardiology (free)

Related – Part I: Trending Cardiovascular Nutrition Controversies – Journal of the American College of Cardiology (free)

Commentary: Chew on This: Review Tackles Controversies in Nutrition for CV Health – TCTMD (free) AND Separating health from hype for a diet that’s kind on your heart – ABC News (free)

 

5 – Ebola outbreak in DRC ends: WHO calls for international efforts to stop other deadly outbreaks in the country – World Health Organization (free)

Commentaries: Deadly Ebola outbreak in Congo is declared over by health ministry – STAT (free) AND Congo declares Ebola flare-up over after rapid response – Reuters (free) AND DRC declares end to Ebola outbreak – CIDRAP (free)

Related: An Ebola Outbreak Has Just Been Stopped. Here’s What It Tells Us About Containing Epidemics – Harvard Business Review (free) AND Ebola: How a killer disease was stopped in its tracks – BBC (free) AND Congo’s Ebola outbreak is all but over. Did an experimental vaccine help? – Science Magazine (free)

 

6 – Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Flare-up of Ebola in Liberian family highlights virus persistence – CIDRAP (free) AND For the First Time, a Female Ebola Survivor Infects Others – The New York Times (10 article per month are free)

 

7 – Antidepressant Withdrawal Syndrome – Therapeutics Initiative (free)

Related Perspective: Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)

Antidepressants should be added to the list of drugs associated with tolerance, dependence and a withdrawal syndrome.”

“Withdrawal symptoms occur in at least one-third of patients who stop.”

 

8 – Development and validation of a cardiovascular disease risk-prediction model using population health surveys: the Cardiovascular Disease Population Risk Tool (CVDPoRT) – Canadian Medical Association Journal (free)

See also: Heart Attack & Stroke Calculator (free tool)

Commentaries: New health calculator can help predict heart disease risk, estimate heart age – CMAJ, via ScienceDaily (free) AND Calculator can predict heart age, risk for heart disease – UPI (free) AND Algorithm Allows Patients To Calculate Their Risk of Stroke and Heart Disease – MedicalResearch.com (free)

Related Calculators: ACC/AHA CV Risk Calculator (free) AND QRISK3-2017 Cardiovascular Disease Risk Calculator (free)

 

9 – When We Eat, or Don’t Eat, May Be Critical for Health – The New York Times (10 articles per month are free)

Original Article: Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes – Cell Metabolism (link to abstract – $ for full-text)

 

10 – Effect of Intermittent Compared With Continuous Energy Restricted Diet on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Noninferiority Trial – JAMA Network Open (free)

Commentaries: Study: 5:2 diet as effective at controlling diabetes as monitoring daily caloric intake – UPI (free) AND HbA1c improves just as much on dieting only two days a week – OnMedica (free) AND Two-Day Fast Per Week vs Daily Calorie Restriction in Diabetes – MedicalResearch.com (free)

 


 

1 – Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018 – International Journal of Stroke (free)

 

2 – Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy – International Journal of Stroke (free)

 

3 – Tropical diseases in the ICU: A syndromic approach to diagnosis and treatment – Journal of Critical Care (free)

 

4 – Reports from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine:

– Sepsis in tropical regions

– Intensive care in severe malaria

– Dengue fever

– Ebola virus disease

– Leptospirosis

– Zika virus

– Chikungunya

Source: Critical Care Reviews Newsletter

 

5 – Policy statement: Food Additives and Child Health – American Academy of Pediatrics (free)

Technical Report: Food Additives and Child Health (free)

Commentaries: Chemicals in Food May Harm Children, Pediatricians’ Group Says – The New York Times (10 articles per month are free) AND Pediatrics Group Issues Statement on Food Additives and Child Health – Physician’s First Watch (free) AND Report: Common food additives may pose danger to kids – University of Washington Medicine (free)

 

6 – Honey for cough in children: can it help? – Evidently Cochrane (free)

Original Cochrane Review: Honey for acute cough in children – Cochrane Library (free) AND Summary: Honey for acute cough in children (free)

 

7 – Richard Lehman’s journal reviews, 23 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Recommendations from the international evidence‐based guideline for the assessment and management of polycystic ovary syndrome – Clinical Endocrinology (free)

 

9 – The 10 fundamental principles of lay resuscitation: Recommendations by the German Resuscitation Council – European Journal of Anaesthesiology (free PDF)

 

10 – Association between maternal adherence to healthy lifestyle practices and risk of obesity in offspring: results from two prospective cohort studies of mother-child pairs in the United States – The BMJ (free)

Commentaries: Mums with healthy habits ‘less likely’ to have obese children – NHS Choices (free) AND Mother’s lifestyle influences child’s obesity risk – Cardiovascular Business (free) AND 5 habits for moms that help prevent childhood obesity – Harvard Medical School (free)

 


 

1 – Guideline: Early and locally advanced breast cancer: diagnosis and management – National Institute for Health and Care Excellence (free)

 

2 – 4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4) – Annals of Oncology (free)

 

3 – Blood pressure targets for the treatment of people with hypertension and cardiovascular disease – Cochrane Library (free)

Summary: Blood pressure targets in people with cardiovascular disease – Cochrane Library (free)

Insufficient evidence to justify lower than standard blood pressure targets in people with hypertension + CVD” (via @CochraneHTN see Tweet)

 

4 – Opinion: Paramedic 2: Epinephrine harms/helps in out of hospital cardiac arrest – First10EM (free)

See Also: Original Article (free study and editorial) AND Expert Reaction (free commentaries)

“Paramedic 2 quick summary:

If 1000 people treated with epinephrine:

– 246 extra ROSC (return of spontaneous circulation)

– 158 extra admissions

– 8 extra survivors (5 with bad neuro outcomes, 3 with good neuro outcomes)

– What those numbers mean is a value question, not a science question.” (via @First10EM see Tweet)

 

5 – Guideline: Human Immunodeficiency Virus Drug Resistance: 2018 Recommendations of the International Antiviral Society–USA Panel – Clinical Infectious Diseases (free) (via @CarlosdelRio7)

 

6 – Report: Miles to go—closing gaps, breaking barriers, righting injustices – UNAIDS (free PDF)

Press Release: UNAIDS warns that progress is slowing and time is running out to reach the 2020 HIV targets (free)

Commentary: U.N. says global fight against AIDS is at ‘precarious point’ – Reuters (free)

Source: International Health Policies Newsletter

 

7 – Advancing global health and strengthening the HIV response in the era of the Sustainable Development Goals: the International AIDS Society—Lancet Commission (free articles and commentaries – registration required)

Commentaries: Report Warns Of ‘Dangerous Complacency’ In The Fight Against HIV – NPR (free) AND ‘Dangerous complacency’ to global HIV epidemic risks resurgence – BBC (free) AND Experts warn approach to HIV/AIDS is complacent – OnMedica (free)

 

8 – Burden of disease in Brazil, 1990–2016: a systematic subnational analysis for the Global Burden of Disease Study 2016 – The Lancet (free)

Related Study: The burden of Neglected Tropical Diseases in Brazil, 1990-2016: A subnational analysis from the Global Burden of Disease Study 2016 – PLOS Neglected Tropical Diseases (free)

 

9 – Definitions and pathophysiology of vasoplegic shock – Critical Care (free)

 

10 – Application of enhanced recovery after gastric cancer surgery: An updated meta-analysis – World Journal of Gastroenterology (free)

Commentary: Enhanced recovery programmes after stomach cancer surgery reduce hospital stay without increasing complications – NIHR Signals (free)

See also: Enhanced Recovery After Surgery Guidelines and Reviews (all free)

 


 

1 – Expert reaction to trial looking at adrenaline for cardiac arrests – Science Media Centre (free)

See original article in yesterday’s issue: A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest (see #1)

Related Review: The role of adrenaline in cardiopulmonary resuscitation – Critical Care (free)

 

2 – A Phase 3 Trial of l-Glutamine in Sickle Cell Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Glutamine to Treat Sickle Cell Disease (free)

Commentary: Drug may ease pain, lessen hospitalization from sickle cell disease – UPI (free)

 

3 – Subacromial decompression versus diagnostic arthroscopy for shoulder impingement: randomised, placebo surgery controlled clinical trial – The BMJ (free)

Commentary: Most common shoulder operation is no more beneficial than placebo surgery – University of Helsinki, via EurekAlert (free)

Related research with similar results: Arthroscopic subacromial decompression for subacromial shoulder pain (free article, editorial and commentaries)

 

4 – Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study – The BMJ (free)

Commentaries: A Spike In Liver Disease Deaths Among Young Adults Fueled By Alcohol – NPR (free) AND Alcohol-related liver failure deaths rising among U.S. young adults – Reuters (free) AND More Americans Are Dying of Cirrhosis and Liver Cancer – The New York Times (10 articles per month are free)

 

5 – Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers – JAMA Oncology (free for a limited period)

Commentary: Association of complementary medicine, cancer treatment, survival – eCancer News (free)

 

6 – Clinical Evidence Synopsis: Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics – JAMA (free for a limited period)

Original Article: Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children – Cochrane Library (link to abstract – $ for full-text) AND Summary: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use (free)

Related Meta-Analysis: Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection (free) AND Probiotics for the Prevention of Clostridium difficile (link to abstract and commentaries)

 

7 – To continue taking or to stop taking antiplatelet drugs for a few days before non-cardiac surgery in adults – Cochrane Library (link to abstract – $ for full-text)

Summary: To continue taking or to stop taking antiplatelet drugs for a few days before non-cardiac surgery in adults – Cochrane Library (free)

We found low-certainty evidence that either continuation or discontinuation of antiplatelet therapy before non-cardiac surgery may make little or no difference to mortality, bleeding requiring surgical intervention, or ischaemic events”.

 

8 – Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study – Journal of the American Heart Association (free)

Commentaries: Poor air quality does not offset exercise’s heart benefits – AHA/ASA Newsroom (free) AND Why smog should not be your excuse to skip workouts – Reuters (free)

 

9 – Metformin and Risk of Hypertension in Taiwanese Patients With Type 2 Diabetes Mellitus – Journal of the American Heart Association (free)

“A reduced risk of hypertension is observed in metformin users in a dose‐response pattern”.

 

10 – Sulfonylureas as second line drugs in type 2 diabetes and the risk of cardiovascular and hypoglycaemic events: population based cohort study – The BMJ (free)

Editorial: Sulfonylureas as second line treatment for type 2 diabetes – The BMJ (free for a limited period)

Commentaries: Diabetes: Switching to Sulfonylureas from Metformin Linked to Increased Side Effects – MedicalResearch.com (free) AND Switching diabetes patients to sulfonylurea linked with complications – Pulse (free) AND Raised risk of MI and mortality when starting sulfonylurea – OnMedica (free)

 


 

1 – A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (free)

Editorial: Testing Epinephrine for Out-of-Hospital Cardiac Arrest (free)

Commentary: Using adrenaline in cardiac arrests results in less than 1 percent more people leaving hospital alive – University of Warwick, via EurekAlert (free)

See also: Infographic detailing result findings (free)

“A clinical trial of the use of adrenaline in cardiac arrests has found that its use results in less than 1% more people leaving hospital alive – but almost doubles the risk of severe brain damage for survivors of cardiac arrest”.

 

2 – Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease – Cochrane Library (link to abstract – $ for full-text)

Cochrane Summaries: New Cochrane health evidence challenges belief that omega 3 supplements reduce risk of heart disease, stroke or death (free) AND Omega-3 intake for cardiovascular disease (free)

Commentaries: Expert reaction to Cochrane review on omega-3 fatty acids and risk of heart disease, stroke and death – Science Media Centre (free) AND Omega 3 supplements don’t protect against heart disease – new review – The Conversation (free)

Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free article and commentary)

 

3 – Randomized Controlled Trial of E-Counseling for Hypertension: REACH – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Virtual counseling helps lower blood pressure – AHA News (free) AND E-counseling can lower blood pressure, heart disease risk – Medical News Today (free)

 

4 – Guideline: Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

5 – The association between nurse staffing and omissions in nursing care: A systematic review – Journal of Advanced Nursing (free)

Commentary: Nurse staffing levels linked to reports of missed care in adult wards – NIHR Signal (free)

 

6 – Global Burden of Atherosclerotic Cardiovascular Disease in People Living with the Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis – Circulation (free PDF)

Commentaries: HIV infection doubles risk of heart disease – University of Edinburgh, via ScienceDaily (free) AND Global Burden of HIV-Related CVD Has Tripled Over Two Decades – TCTMD (free)

 

7 – Report: Feeding in the first year of life – Scientific Advisory Committee on Nutrition (SACN) (free)

Commentaries: SACN publishes ‘Feeding in the first year of life’ report – Public Health England (free) AND Too many babies overfed, experts fear – BBC (free)

 

8 – Contrary to common belief, randomised controlled trials inevitably produce biased results – LSE Impact Blog (free)

Original Article: Why all randomised controlled trials produce biased results – Annals of Medicine (free)

Source: Nature Briefing Newsletter

 

9 – CBT for anxiety: new meta-analysis confirms significant improvements to target symptoms – The Mental Elf (free) (via @AllenFrancesMD)

Original article: Cognitive behavioral therapy for anxiety and related disorders: A meta-analysis of randomized placebo-controlled trials – Depression and Anxiety (free)

 

10 – Are electronic nicotine delivery systems helping cigarette smokers quit? Evidence from a prospective cohort study of U.S. adult smokers, 2015–2016 – PLOS One (free)

Commentaries: More Than 90 Percent Of Smokers Using E-cigarettes Still Smoking A Year Later – Georgia State University (free) AND Study casts doubt on effectiveness of e-cigs for smoking cessation – National Institutes of Health (free) AND Vaping May Not Help Smokers Kick the Habit – MedPage Today (free registration required)

 


 

1 – Association of Digital Media Use With Subsequent Symptoms of Attention-Deficit/Hyperactivity Disorder Among Adolescents – JAMA (link to abstract – $ for full-text)

Commentaries: More Screen Time For Teens Linked To ADHD Symptoms – NPR (free) AND Digital media use linked to behavioral problems in kids – University of Southern California, via ScienceDaily (free) AND Screen time linked to ADHD symptoms in teens – Reuters (free) AND ADHD study links teens’ symptoms with digital media use – CNN (free) AND Expert reaction to association of digital media use and ADHD symptoms among teenagers – Science Media Centre (free)

 

2 – Perspective: “Is There a Doctor on the Plane?” – JAMA (free for a limited period)

Interview: “Is There a Doctor on the Plane?” (free)

 

3 – Guideline for the treatment of chronic lymphocytic leukaemia: A British Society for Haematology Guideline (free)

 

4 – Report: Open Science by Design: Realizing a Vision for 21st Century Research (2018) – National Academies of Sciences, Engineering, and Medicine (free PDF)

News Release: Report Proposes Recommendations and New Framework to Speed Progress Toward Open Science (free)

 

5 – Clinical Trial Evidence Supporting FDA Approval of Drugs Granted Breakthrough Therapy Designation – JAMA (link to abstract – $ for full-text)

Commentaries: Are ‘breakthrough’ drugs as safe as other FDA-approved medicines? – CNN (free) AND Evidence to support ‘breakthrough’ drugs often very limited: study – Reuters (free)

 

6 – Head To Head: Does evidence based medicine adversely affect clinical judgment? – The BMJ (free) (via @michelaccad)

 

7 – Harms Reporting in Randomized Controlled Trials of Interventions Aimed at Modifying Microbiota: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Reporting on risks often inadequate for prebiotics, probiotics, synbiotics – ACP Internist (free) AND Probiotics studies often don’t disclose safety data or risks, report finds – STAT (free) AND Safety of Probiotic Supplements Is Not Guaranteed, Study Says – Consumer Reports (free)

“How to make an intervention safe? Don’t report the adverse events”. (via @EricTopol see Tweet)

 

8 – Review: Noninvasive ventilation in acute respiratory failure: which recipe for success? – European Respiratory Review (free)

Source: Critical Care Reviews Newsletter

 

9 – Auscultation for bowel sounds in patients with ileus: an outdated practice in the ICU? – Netherlands Journal of Critical Care (free PDF)

Editorial: It’s not a gut feeling: don’t listen to the bowels (free PDF)

Source: Critical Care Reviews Newsletter

 

10 – Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality – Gut (free)

Commentaries: FOB associated with rise in all-cause mortality – OnMedica (free) AND 3 key findings from Gut study on all-cause mortality associated with occult blood in stool – GI & Endoscopy (free) AND Fecal Occult Blood Flags Risks Beyond Colon Cancer – MedPage Today (free)

 


 

1 – Systematic Review: Nurses as substitutes for doctors in primary care – Cochrane Library (free)

Summary: Nurses as substitutes for doctors in primary care – Cochrane Library (free)

“This updated Cochrane Review indicates that nurses can effectively expand the capacity of the primary care workforce”.

 

2 – Comparison of Antibiotic Prescribing in Retail Clinics, Urgent Care Centers, Emergency Departments, and Traditional Ambulatory Care Settings in the United States – JAMA Internal Medicine (free for a limited period)

Commentaries: Overprescription in Urgent Care Clinics—The Fast and the Spurious – JAMA Internal Medicine (free for a limited period) AND Urgent care centers often prescribe unnecessary antibiotics – Reuters (free) AND Study spotlights inappropriate prescribing in urgent care – CIDRAP (free)

 

3 – Clinical Review: Novel therapies for diabetes mellitus in pregnancy – The BMJ (free for a limited period)

 

4 – 9 in 10 infants worldwide received vaccinations in 2017 – World Health Organization (free)

 

5 – Integrating Responses at the Intersection of Opioid Use Disorder and Infectious Disease Epidemics: Proceedings of a Workshop – National Academies of Sciences, Engineering and Medicine (free)

Commentaries: National Academies target opioid abuse and infectious disease consequences – Emory Health Sciences (free) AND Within opioid abuse epidemic, infectious disease epidemic emerges – Reuters (free)

 

6 – Richard Lehman’s journal review, 16 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

7 – Is your cellphone giving you cancer? A comprehensive guide to the messy, frustrating research – VOX (free)

 

8 – Risks of ovarian, breast, and corpus uteri cancer in women treated with assisted reproductive technology in Great Britain, 1991-2010: data linkage study including 2.2 million person years of observation – The BMJ (free)

Commentaries: No association found between fertility treatment, some types of cancer – ACP Internist (free) AND Fertility treatment does not appear to raise serious cancer risk – OnMedica (free)

 

9 – Smartphone-based screening for visual impairment in Kenyan school children: a cluster randomised controlled trial – The Lancet Global Health (free)

Commentaries: Strengthening eye health evidence for children in low-income and middle-income countries (free) AND App screening boosts children’s eye health – Medical Health News (free)

 

10 – International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging (free)

Related: Polypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) AND The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF) AND Common ED Medication Errors: Polypharmacy – emDocs (free) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free) AND The other big drug problem: Older people taking too many pills – The Whashington Post (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) 

 


 

1 – Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials – The Lancet (free)

Commentaries: Weight-adjusted aspirin for cardiovascular prevention – The Lancet (free) AND One dose of aspirin doesn’t fit all – University of Oxford (free)

Practice Changing Article. “Low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and had no benefit in the 80% of men and nearly 50% of all women weighing 70 kg or more. By contrast, higher doses of aspirin were only effective in patients weighing 70 kg or more.”

 

2 – Vulnerability to snakebite envenoming: a global mapping of hotspots – The Lancet (free)

Commentaries: Addressing the global challenge of snake envenoming – The Lancet (free) AND New study maps the areas where people are most vulnerable to death following snakebite – London School of Tropical Medicine (free) AND New study finds 93 million people vulnerable to death from snakebites – Institute for Health Metrics and Evaluation (free)

 

3 – Association of Inferior Vena Cava Filter Placement for Venous Thromboembolic Disease and a Contraindication to Anticoagulation With 30-Day Mortality – JAMA Network Open (free)

Commentaries: Inferior Vena Cava Filters and Mortality: Is It the Underlying Process, the Patient, or the Device? (free)

“Could IVC filters be causing harm? They began being used before @US_FDA started approving devices. This article raises possibility of increased mortality. Maybe where we need trials to determine safety and effectiveness”. (via @hmkyale see Tweet)

 

4 – 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis – Annals of Rheumatic Disease (free)

 

5 – 2018 Guidelines of the Taiwan Society of Cardiology, Taiwan Society of Emergency Medicine and Taiwan Society of Cardiovascular Interventions for the management of non ST-segment elevation acute coronary syndrome – Journal of the Formosan Medical Association (free)

Related Guidelines: 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (free) AND 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes (free)

 

6 – CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) in 2018 – Japanese Association of Cardiovascular Intervention and Therapeutics (free)

 

7 – Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility – Toxicological Sciences (free)

Commentaries: New digital chemical screening tool could help eliminate animal testing – Science (free) AND Database Analysis More Reliable Than Animal Testing For Toxic Chemicals – Johns Hopkins Bloomberg School of Public Health (free) AND Software beats animal tests at predicting toxicity of chemicals – Nature News (free)

 

8 – Review: Cardiac rehabilitation: A class 1 recommendation – Cleveland Clinic Journal of Medicine (free)

Related Guidelines: Cardiac rehabilitation – Scottish Intercollegiate Guidelines Network (free) AND Myocardial infarction: cardiac rehabilitation and prevention of further cardiovascular disease – National Institute for Health and Care Excellence (free)

 

9 – Hypertension Among Youths — United States, 2001–2016 – Centers for Disease Control and Prevention (free)

Commentaries: 800,000 More Adolescents Classified as Hypertensive Under New Guidelines – NEJM Physician’s First Watch (free) AND New guidelines label 795K more US children as hypertensive – Cardiovascular Business (free)

 

10 – Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study – American Journal of Clinical Nutrition (free for a limited period)

Commentaries: Study finds no significant link between whole dairy products and heart disease, stroke – News Medical (free) AND Full-fat dairy may actually benefit heart health – Medical News Today (free)

Related Studies: Meta-Analysis: Cheese consumption and risk of cardiovascular disease (link to abstract and commentaries) AND Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality (free study and commentaries)

 


 

1 – INSPIRE: Seven strategies for ending violence against children – World Health Organization (free resources)

Fact Sheet: Violence against children – World Health Organization (free)

The package includes the core document describing what the INSPIRE strategies and interventions are; an implementation handbook that provides details on how to implement the interventions, and a set of indicators to measure the uptake of INSPIRE and its impact on levels of violence against children.

 

2 – Comparison of the Safety Planning Intervention With Follow-up vs Usual Care of Suicidal Patients Treated in the Emergency Department – JAMA Psychiatry (free for a limited period)

Author Interview: Association of Safety Planning Intervention With Subsequent Suicidal Behavior Among ER-Treated Suicidal Patients (free)

Commentaries: ED Intervention with Follow-Up Appears to Reduce Suicidal Behaviors – NEJM Physician’s First Watch (free) AND A Simple Emergency Room Intervention Can Help Cut Suicide Risk – NPR (free)

Related Studies: Suicide Prevention in an Emergency Department Population (free study and commentaries) AND Strategies to prevent death by suicide (link to abstract and commentaries)

 

3 – Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Bleeding Risk Increased With NSAID Use in Anticoagulated A-fib Patients: RE-LY Analysis – TCTMD (free) AND NSAID, anticoagulant combo ups risk for bleeding events in AFib patients – Cardiovascular Business (free) Concomitant NSAIDs and Anticoagulants in Atrial Fibrillation – American College of Cardiology (free)

 

4 – Infographic: Testing for non-alcoholic fatty liver disease -The BMJ (free PDF)

 

5 – The right diet can boost potency of cancer drugs – Nature News (free)

Original article: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors – Nature (link to abstract – $ for full-text)

Related: Top oncologist to study effect of diet on cancer drugs – The Guardian (free)

“Diets appear to matter in mouse cancer Rx – can these preclinical findings be translated to humans?” (via @Aiims1742 see Tweet)

 

6 – Report: Research into physiotherapy for musculoskeletal conditions – NIHR Dissemination Centre (free PDF)

This new NIHR report brings together key research relevant to those delivering musculoskeletal physiotherapy services.

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: June 2018 – eCancer News (free)

This review has an interesting opinion on changing definitions of clinically meaningful endpoints in cancer research.

 

8 – Research Methods & Reporting: Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians – The BMJ (free)

 

9 – Anticoagulation for perioperative thromboprophylaxis in people with cancer – Cochrane Library (free)

Summary: Blood thinners for the prevention of blood clots in people with cancer undergoing surgery – Cochrane Library (free)

 

10 – Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Stopping the Alteplase Indication Creep – Emergency Medicine Literature of Note (free) AND Alteplase unlikely to reduce disability after mild stroke without disabling deficits – 2 Minute Medicine (free) AND Lytic No Better Than Aspirin for Mild Ischemic Stroke – MedPage Today (free registration required)

 


 

1 – Guideline: Rheumatoid arthritis in adults: management – National Institute for Health and Care Excellence (free)

 

2 – Guideline: Brain tumours (primary) and brain metastases in adults – National Institute for Health and Care Excellence (free)

 

3 – Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study – The BMJ (free)

Commentary: Expert reaction to study looking at American blood pressure guidelines and how many people in the USA and China would be classed as having high blood pressure – Science Media Centre (free)

 

4 – Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy (link to abstract – $ for full-text)

Commentary: Is Short-Course Antibiotic Treatment for CAP Effective? – MPR (free)

 

5 – News Release: Trial wipes out more than 80 per cent of disease-spreading mozzie – Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Government (free)

Commentary: Australian experiment wipes out over 80% of disease-carrying mosquitoes – CNN (free)

 

6 – Perspective: Fractional-Dose Yellow Fever Vaccination — Advancing the Evidence Base – New England Journal of Medicine (free)

Related Research: Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Preliminary Report – The New England Journal of Medicine (free)

 

7 – Cumulative Incidence of Hypertension by 55 Years of Age in Blacks and Whites: The CARDIA Study – Journal of the American Heart Association (free)

Commentaries: Most black adults have high blood pressure before age 55 – AHA / ASA Newsroom (free) AND New CARDIA Data: 75% of African-Americans Have Hypertension by Age 55 – TCTMD (free)

 

8 – News Release: FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions – U.S. Food and Drug Administration (free)

Commentaries: FDA Strengthens Warnings for Fluoroquinolone Antibiotics – MPR (free) AND FDA Announces Labeling Changes for Fluoroquinolones Due to Mental Health AEs, Blood Sugar Disturbances – MD Magazine (free)

 

9 – Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study – The Lancet Public Health (free)

Commentaries: A painful lesson: are we repeating previous mistakes in pain management? – The Lancet Public Health (free) AND Use of illicit cannabis does not reduce chronic pain, according to new Australian study – RACGP (free)

Related: Efficacy and adverse effects of medical marijuana for chronic noncancer pain: Systematic review of randomized controlled trials – Canadian Family Physician (free) AND Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review – VA Evidence-based Synthesis Program (free) AND Cannabis products for adults with chronic neuropathic pain – Cochrane Library (free)

 

10 – Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Smoking Marijuana May Be Tied to Cough, Sputum Production – HealthDay (free) AND Regular marijuana use is associated with development of respiratory issues – 2 Minute Medicine (free)

 


 

1 – Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorial: USPSTF Recommendations for Assessment of Cardiovascular Risk With Nontraditional Risk Factors: Finding the Right Tests for the Right Patients (free)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) level, or coronary artery calcium (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.

 

2 – Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)

Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)

Commentaries: Study: Multivitamins Do Not Prevent Strokes, Heart Attacks or Cardiovascular Disease Deaths – University of Alabama at Birmingham, via NewsWise (free) AND Multivitamin-mineral supplements do not reduce heart disease, deaths – Reuters (free)

Related: Supplements Not Effective for CVD Prevention and Treatment (link to abstract and commentaries) AND Multivitamins are probably a waste of money (free commentaries)

 

3 – Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Newer, older insulin formulations may offer similar glucose-lowering effects – ACP Internist (free) AND HbA1c Reduction Similar in Old, New Basal Insulin Analogues – MedPage Today (free registration required)

 

4 – Association of Early Introduction of Solids With Infant Sleep: A Secondary Analysis of a Randomized Clinical Trial – JAMA Pediatrics (free)

Author Interview: Effects of Early Solid Food Introduction on Infant Sleep (free audio)

Commentaries: Babies fed solids earlier ‘sleep better’ – NHS Choices (free) AND Feeding your baby solids early may help them sleep, study suggests – The Guardian (free) AND Giving your baby solid food early won’t help them sleep better – The Conversation (free)

 

5 – Effect of a Home-Based Wearable Continuous ECG Monitoring Patch on Detection of Undiagnosed Atrial Fibrillation: The mSToPS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video: Effect of a Home-Based Wearable ECG Patch Monitor on Detection of Undiagnosed Atrial Fibrillation in Individuals at Increased Risk of Atrial Fibrillation (free)

Commentary: If You Look For Atrial Fibrillation You Will Find Atrial Fibrillation – Cardiobrief (free)

Related: Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? (free commentaries)

 

6 – Review: Update on infection control practices in cancer hospitals – CA: A Cancer Journal of Clinicians (free)

 

7 – Review:  Optimal pain management for patients with cancer in the modern era – CA: A Cancer Journal of Clinicians (free)

 

8 – Periconception glycaemic control in women with type 1 diabetes and risk of major birth defects: population based cohort study in Sweden – The BMJ (free)

Commentary: Higher risk of heart defects in babies of mothers with type 1 diabetes – Karolinska Institutet, via EurekAlert (free)

 

9 – Public health implications of overscreening for carotid artery stenosis, prediabetes, and thyroid cancer – Public Health Reviews (free)

 

10 – Consensus Report: Returning Individual Research Results to Participants: Guidance for a New Research Paradigm (2018) – National Academies of Sciences, Engineering, and Medicine (free PDF)

Commentaries: National Academies panel urges researchers to routinely share test results with study participants – STAT (free) AND If you give your DNA and tissues to science, should you get a peek at what they might contain? – Science (free) AND New report says individual research results should be shared with participants more often – National Academies of Sciences, Engineering, and Medicine (free)

Related Viewpoint: Return of Research Results to Study Participants: Uncharted and Untested – JAMA (free for a limited period)

 


 

1 – Summary of the international clinical guidelines for the management of hospital-acquired and ventilator-acquired pneumonia – ERJ Open Research (free)

Editorial: Treating nosocomial pneumonia: what’s new (free)

Related Guidelines: International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) AND Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society (free)

Source: Critical Care Reviews Newsletter

 

2 – Guideline: Recommendations on screening for asymptomatic bacteriuria in pregnancy – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers / other resources from CTFPHC (all free)

 

3 – Draft Statement: Antibiotics should be restricted for COPD – National Institute for Health and Care Excellence (free)

Commentaries: Antibiotics should be restricted for COPD, says NICE – OnMedica (free) AND UK officials recommend limits on antibiotics for COPD – CIDRAP (free)

The draft antimicrobial guidance recommends that antibiotics should be offered to people who have a severe flare up of symptoms, also known as a severe acute exacerbation”

 

4 – Oposition to Breast-Feeding Resolution by U.S. Stuns World Health Officials – The New York Times (10 articles per month are free)

 

5 – Richard Lehman’s journal review, 9 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals

 

6 – Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Cabozantinib in Hepatocellular Carcinoma – NEJM Resident 360 (free)

Median overall survival was 10.2 months with cabozantinib and 8.0 months with placebo, but the rate of high-grade adverse events in the cabozantinib group was approximately twice that observed in the placebo group. (more on this study in Richard Leeman’s review above)

 

7 – Percutaneous coronary intervention for stable angina in ORBITA – Authors’ reply – The Lancet (free) – The Lancet (free)

Original study: Percutaneous coronary intervention in stable angina (ORBITA) (link to abstract and commentaries)

Related commentaries: Viewpoint: Placebo Effect of the Heart (free) AND Sham Surgeries: A Tale of Medical Reversals & the Role of the Media (free)

Related research: Research: Physiology-Stratified Analysis of ORBITA (free research and commentaries)

 

8 – Richard Smith: Reducing global road traffic crashes and injuries – The BMJ Opinion (free)

Related reports: The High Toll of Traffic Injuries : Unacceptable and Preventable – The World Bank (free PDF) AND Save LIVES: a road safety technical package (free) AND Unfinished Journey: The Global Health Response to Children & Road Traffic – FIA Foundation (free PDF) AND Securing safe roads: the politics of change – World Resources Institute Ross Center for Sustainable Cities (free news release and PDF)

 

9 – Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)

Summary: Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)

Related Research: Randomized Trial: Negative Pressure Wound Therapy No Better Than Regular Dressing in Severe Open Fracture of the Lower Limb (link to abstract and commentaries)

 

10 – Physician Burnout, Well-being, and Work Unit Safety Grades in Relationship to Reported Medical Errors – Mayo Clinic Proceedings (link to abstract – $ for full-text)

Commentaries: Medical errors may stem more from physician burnout than unsafe health care settings – Stanford Medicine, via ScienceDaily (free) AND Physician burnout, depression can lead to major medical errors: Study – ABC News (free) AND Burnout Tied to Twofold Higher Risk for Medical Errors – Medscape (free registration required)

Related: Perspective: The Burnout Crisis in American Medicine (free commentaries on the subject)

 


 

1 – Guidelines On The Management Of Acute Respiratory Distress Syndrome – Intensive Care Society (free PDF) (via @CritCareReviews)

Related Guidelines: The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free) AND An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome (free)

 

2 – WHO Manual: Preventing disease through a healthier and safer workplace – World Health Organization (free PDF)

Source: International Health Policies Newsletter

 

3 – Clinical Update: Long-acting Reversible Contraception—Highly Efficacious, Safe, and Underutilized – JAMA (free for a limited period)

Clinical Review Audio: Return of the IUD: Long-acting Reversible Contraception Is Safe and Effective (free)

 

4 – Seriously, Juice Is Not Healthy – The New York Times (10 articles per month are free)

“Would you take a multivitamin if it contained 10 teaspoons of sugar? No. Then why are you drinking juice?” (via @NYTHealth see Tweet)

 

5 – Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: For Women Over 30, There May Be A Better Choice Than The Pap Smear – NPR (free) AND Study Suggests HPV Test More Accurate Than Pap Smear for Cervical Cancer Screening – AJMC (free) AND HPV testing could be more accurate than smear tests for initial screening of cervical cancer – NHS Choices (free)

 

6 – The health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes – Environmental Research (free) (via @Mental_Elf and @AllenFrancesMD)

Commentary: It’s official — spending time outside is good for you – University of East Anglia, via ScienceDaily (free)

 

7 – A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less? – BioMed Research International (free)

Related Meta-Analysis:  Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)

Source: Critical Care Reviews Newsletter

 

8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: Ebola virus outbreak likely over in Congo, WHO says – NBC News (free) AND Good news: the Ebola outbreak in DRC is contained – VOX (free)

 

9 – Use of ‘smart drugs’ on the rise – Nature (free)

Related: A ‘smart’ approach to performance drugs – ACP Internist (free) AND Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)

 

10 – Association of Prenatal Exposure to Population-Wide Folic Acid Fortification With Altered Cerebral Cortex Maturation in Youths – JAMA Psychiatry (free)

Commentaries: Folic acid linked to healthy brain development through childhood – Reuters (free) AND Folic Acid Fortification May Have Role in Sustaining Mental Health – AJMC (free) AND Prenatal Exposure to Folic Acid Appears to Promote Healthy Brain Development – Psychiatric News Alert (free) AND Perinatal Folic Acid May Protect Against Serious Mental Illness in Young People – MedicalResearch.com (free)

 


 

1 – Report: Delivering quality health services: A global imperative for universal health coverage – World Health Organization (free)

News Release: Low quality healthcare is increasing the burden of illness and health costs globally (free)

Commentary: Universal quality healthcare coverage—a commitment to building a healthier and more productive society – The BMJ Opinion (free)

Related: Handbook for national quality policy and strategy: A practical approach for developing policy and strategy to improve quality of care – World Health Organization (free)

 

2 – Hypothalamic–Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free PDF)

Commentaries: Up to half of childhood cancer survivors will develop hormone disorders – The Endocrine Society, via ScienceDaily (free) AND Guideline Addresses Endocrine Effects After Childhood Cancer – Medscape (free registration required)

 

3 – Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer: A Life-Table Model – JAMA Oncology (free)

Editorial: Implementation Challenges for Risk-Stratified Screening in the Era of Precision Medicine (free)

Author Interview: Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Breast Cancer Screening (free)

Commentaries: New approach to breast cancer screening — tailoring guidelines for each patient — may save lives and money, study says – STAT (free) AND No screening is better for women with low breast cancer risk, finds study – Guardian (free) AND Breast Cancer Screening Only for Women at Higher Risk – Medscape (free registration required)

 

4 – Review: Heart failure with preserved ejection fraction: from mechanisms to therapies – European Heart Journal (free)

 

5 – Review: Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies – Circulation (free)

 

6 – Hidden conflicts? – Science Magazine (free)

““Pay-later conflicts of interest” have gone largely unnoticed & entirely unpoliced”. (via @cpiller see Tweet)

 

7 – Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview – European Spine Journal (free)

 

8 – Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care – The BMJ (free)

Commentary: Analysis Finds Less Bleeding — But Potentially Greater Mortality Risk — with Some Newer Anticoagulants – NEJM Physician’s First Watch (free)

 

9 – Species-specific activity of antibacterial drug combinations – Nature (link to abstract – $ for full-text)

Commentaries: Study: For antibiotics, good things may come in pairs – CIDRAP (free) AND Combining antibiotics alters effectiveness, study says – UPI (free) AND As drug resistance grows, combining antibiotics could turn up new treatments – STAT (free)

 

10 – Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial – The Lancet Infectious Diseases (free)

Invited Commentary: Preventing urinary tract infections in patients with neurogenic bladder (free)

 


 

1 – Guideline for Antibiotic Use in Adults with Community-acquired Pneumonia – The Korean Society of Infectious Disease (free)

Related Guideline: Pneumonia: Diagnosis and Management of Community- and Hospital-Acquired Pneumonia in Adults – National Institute for Health and Care Excellence (free)

 

2 – An evidence-based approach to evaluation and management of the febrile child in Indian emergency department – International Journal of Critical Illness & Injury Science (free)

 

3 – Pathophysiology, diagnosis and management of MINOCA: an update – European Heart Journal: Acute Cardiovascular Care (free)

 

4 – Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study – Journal of the American Heart Association (free)

Editorial: Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): It’s Time to Face Reality! (free)

 

5 – Treatment of Angina: Where Are We? – Cardiology (free)

Source: Critical Care Reviews Newsletter

 

6 – Adverse effect of long work hours on incident diabetes in 7065 Ontario workers followed for 12 years – BMJ Open Diabetes Research & Care (free)

Commentaries: Clocking up 45+ working hours/week linked to heightened risk of diabetes in women – BMJ, via ScienceDaily (free) AND Greater Risk of Diabetes in Women With Longer Work Week – MedicalResearch.com (free)

Related Study: Effect of Work Stressors on the Risk of Type 2 Diabetes (link to abstract and commentary)

 

7 – Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates – Nature Medicine (link to abstract – $ for full-text)

Commentaries: Pregnancy loss occurs in 26 percent of Zika-infected monkeys – NIH News Releases (free) AND Monkey studies suggest Zika role in miscarriage may be higher than thought – CIDRAP (free)

 

8 – Alarming polio outbreak spreads in Congo, threatening global eradication efforts – Science (free)

 

9 – Carbohydrate Replacement of Rice or Potato with Lentils Reduces the Postprandial Glycemic Response in Healthy Adults in an Acute, Randomized, Crossover Trial – The Journal of Nutrition (link to abstract – $ for full-text)

Commentaries: Lentils significantly reduce blood glucose levels – University of Guelph, via ScienceDaily (free) AND Replace Carbs With Lentils to Blunt Glucose Spike After Meals – Medscape (free registration required)

 

10 – Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease Risk Factor Development: An Observational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Hypertensive disorders during pregnancy associated with increased rates of later CVD – ACP Internist (free) AND High blood pressure in pregnancy tied to heart disease risk afterward – Reuters (free) AND Women who experience hypertensive disorders during pregnancy are at high risk for developing high blood pressure, diabetes, and high cholesterol later in life – 2 Minute Medicine (free)

Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries) AND Gestational Hypertension and Future Risk of Cardiovascular Disease (free research and editorial)

 


 

1 – Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis – Canadian Medical Association Journal (free)

Commentaries: Class of drugs used as alternative to opioids for back pain are ineffective, have potentially serious side effects: report – The Globe and Mail (free) AND Anticonvulsant drugs ineffective for low back pain and can cause harm, despite increased prescribing – CMAJ, via EurekAlert (free)

Related Meta-Analysis: Benefits and safety of gabapentinoids in chronic low back pain (free research and commentaries)

 

2 – The Carbohydrate-Insulin Model of Obesity: Beyond “Calories In, Calories Out” – JAMA Internal Medicine (free for a limited period)

 

3 – Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Epinephrine vs. Norepinephrine for Cardiogenic Shock – American College of Cardiology (free) AND Norepinephrine Bests Epinephrine in Battle of the Vasopressors in Cardiogenic Shock – TCTMD (free)

 

4 – Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Related Perspective: Metastasis-free Survival — A New End Point in Prostate Cancer Trials – New England Journal of Medicine (free)

Commentaries: Enzalutamide: Now Also for Earlier Use in Prostate Cancer? – Medscape (free registration required) AND Enzalutamide Improves Outcomes for Aggressive Prostate Cancer – MPR (free) AND Enzalutamide Postpones Metastasis for a Subset of High-Risk Patients With Prostate Cancer – Cancer Therapy Advisor (free)

 

5 – Editorial: Immunotherapy: hype and hope – The Lancet Oncology (free) (via @OphiraG)

Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)

 

6 – Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM – Recommendations and Statements for Girls and Women – Geburtshilfe Frauenheilkd (free)

Related guidelines: Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free) AND Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines – Clinical and Experimental Reproductive Medicine (free) AND Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline – Human Fertility (free)

 

7 – Influenza vaccine for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

Summary: Influenza vaccine for people with chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

 

8 – Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies – The Lancet (link to abstract – $ for full-text)

Commentaries: Increased risk of birth defects in babies after first-trimester exposure to lithium – Mount Sinai School of Medicine, via ScienceDaily (free) AND Lithium in Pregnancy Tied to Infant Morbidity, Malformation Risk – Medscape (free)

 

9 – Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study – The BMJ (free)

In this large international, population-based database, no evidence was found of an overall increased risk of congenital anomalies after first trimester metformin exposure.

 

10 – Australia wins landmark WTO ruling on plain tobacco packaging – Reuters (free)

Other commentaries: WTO Tobacco Ruling Opens Door to New Plain-Packaging Laws – Bloomberg (free) AND ‘Resounding victory’: Australia wins tobacco plain packaging dispute – The Guardian (free) AND Australian Tobacco Plain Packaging Upheld In Decision At WTO – Intellectual Property Watch (free)

Source: International Health Policies Newsletter

 


 

1 – A Multicenter Study of Patient-Reported Infectious and Noninfectious Complications Associated With Indwelling Urethral Catheters – JAMA Internal Medicine (free)

Commentary: Foleys Aren’t Fun: Patient Study Shows Catheter Risks – University of Michigan, via NewsWise (free)

“More than half of patients surveyed while they had a urinary catheter, and again weeks later, reported a complication – and infections were only part of the problem” (from NewsWise)

 

2 – Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

“Out-of-hours discharge from an ICU is strongly associated with both in-hospital death and ICU readmission. Whether these increases in mortality and readmission result from patient differences, differences in care, or a combination remains unclear”.

 

3 – Review: Chronic hyperkalemia in non-dialysis CKD: controversial issues in nephrology practice – Journal of Nephrology (free)

 

4 – Opinion: Endless Gaming May Be a Bad Habit. That Doesn’t Make It a Mental Illness – The New York Times (10 articles per month are free)

Related: Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free)

“The World Health Organization has made “internet gaming” a diagnosable disorder. But many experts aren’t even sure it exists”.

 

5 – Richard Lehman’s journal review, 2 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

6 – Outbreak of Ebola virus disease in the Democratic Republic of the Congo, April–May, 2018: an epidemiological study – The Lancet (free)

Invited Commentary: Ebola virus disease: 11 323 deaths later, how far have we come? (free)

Related: Ebola Outbreak in Congo ‘Largely Contained’, says WHO (free statement and commentary)

 

7 – Management of multimorbidity using a patient-centred care model: a pragmatic cluster-randomised trial of the 3D approach – The Lancet (free)

Commentaries: Patient-centred care for multimorbidity: an end in itself? – The Lancet (free) AND Results of the largest ever multimorbidity trial in primary care challenge current thinking -NIHR News (free)

Related: Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers (series of free articles on the topic) AND Multimorbidity: A Priority for Global Health Research (free report and commentaries)

“In the largest ever trial of an intervention to treat people with multiple long-term conditions (multimorbidity) in primary care, NIHR-researchers found that the patient-centred approach taken improved patients’ experience of their care but did not improve their health-related quality of life. This is a challenge to current thinking on which UK and international guidelines are based”. (from NIHR News)

 

8 – Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Expert reaction to research association between coffee and lower risk of death – Science Media Centre (free) AND Fresh grounds for coffee: Study shows it may boost longevity – Associated Press (free) AND Coffee Drinkers Are More Likely To Live Longer. Decaf May Do The Trick, Too – NPR (free)

Related Studies: Meta-Analysis: Coffee consumption and health (free research and commentaries) AND Coffee Drinking and Mortality Studies (link to abstract and commentaries)

Another observational study showing possible benefits from drinking coffee.

 

9 – Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood: A Danish Population-Based Cohort Study – JAMA Network Open (free)

Invited Commentary: Unmet Survivorship Care Needs of Adolescent and Young Adult Cancer Survivors (free)

Related Reviews: Endocrine late-effects of childhood cancer and its treatments – European Journal of Endocrinology (free) AND Metabolic syndrome induced by anticancer treatment in childhood cancer survivors – Annals of Pediatric Endocrinology & Metabolism (free) AND Screening and management of adverse endocrine outcomes in adult survivors of childhood and adolescent cancer – The Lancet Diabetes & Endocrinology (free)

 

10 – Cardiovascular Toxicity in Cancer Survivors: Current Guidelines and Future Directions – American College of Cardiology (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)

 


 

1 – Continuity of care with doctors—a matter of life and death? A systematic review of continuity of care and mortality – BMJ Open (free)

Commentaries: Seeing same doctor every time ‘reduces risk of death’ – NHS Choices (free) AND Sticking with 1 doctor could have health benefits: Study – UPI (free)

 

2 – Opinion: Why do-it-yourself blood tests are a bad idea – Common Sense Family Doctor (free)

Related: Benjamin Mazer: Theranos’ dystopian vision lives on – The BMJ Opinion (free)

“Routine blood testing in healthy people has numerous downsides that Holmes never mentioned, including poor predictive value, false positives, and overdiagnosis” (from Common Sense Family Doctor)

“When you go about testing everyone for everything, you don’t create a world of healthy people….you create a nightmare where everyone is sick” (from The BMJ Opinion)

 

3 – Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free)

Related: Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

“Great new study about science outreach via Twitter: Initially, scientists mostly tweet to each other. But after accumulating about 1000 followers, scientists reach an increasing number of journalists, policy makers, and other members of the public”. (via @JSheltzer see Tweet)

 

4 – Four principles to make evidence synthesis more useful for policy – Nature (free)

Related: A fresh approach to evidence synthesis – Nature (free)

“Reward the creation of analyses for policymakers that are inclusive, rigorous, transparent and accessible, urge Christl A. Donnelly and colleagues”.

 

5 – American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome – American Journal of Gastroenterology (free for a limited period)

Related guidelines: Irritable bowel syndrome in adults: diagnosis and management – National Institute for Health and Care Excellence (free) AND Clinical Practice Guidelines for Irritable Bowel Syndrome in Korea, 2017 Revised Edition – Journal of Neurogastroenterology and Motility (free) AND Evidence-based clinical practice guidelines for irritable bowel syndrome – Journal of Gastroenterology (free)

Source: NewsWise

 

6 – Update of Recommendations for Use of Once-Weekly Isoniazid-Rifapentine Regimen to Treat Latent Mycobacterium tuberculosis Infection – Centers for Disease Control and Prevention (free)

Commentary: CDC Updates Guidelines on Weekly Therapy for Latent TB Infection – Physician’s First Watch (free)

Related WHO Guideline: Latent TB Infection (free guideline and news release)

 

7 – The plateau of human mortality: Demography of longevity pioneers – Science (link to abstract – $ for full-text)

Commentaries: There’s no limit to longevity, says study that revives human lifespan debate – Nature News (free) AND Italian study suggests human lifespan could continue increasing – NHS Choices (free) AND Age 105? Then you’ve a better chance of living even longer – The Guardian (free) AND How Long Can We Live? The Limit Hasn’t Been Reached, Study Finds – The New York Times (free)

 

8 – Editorial: HPV vaccination: balancing facts – Cochrane Library (free)

Related Cochrane Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer (link to review and commentaries)

 

9 – Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

Summary: Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

Related Meta-Analysis: Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)

This Cochrane review suggests mineralocorticoid receptor antagonists may be of benefit to reduce hospitalizations, while the meta-analysis in Heart suggests beta-blockers may improve all-cause and cardiovascular mortality…

 

10 – The 2016 global and national burden of diabetes mellitus attributable to PM2·5 air pollution – The Lancet Planetary Health (free)

Commentaries: Air pollution and diabetes: it’s time to get active! – The Lancet Planetary Health (free) AND Air pollution linked to 3.2 million new diabetes cases in one year – CNN (free) AND Air pollution contributes significantly to diabetes globally – Washington University School of Medicine (free)

Related: WHO Report: 9 out of 10 People Worldwide Breathe Polluted Air (free report and commentaries) AND Ambient Air Pollution in Relation to Diabetes (free research) AND The Lancet Commission on pollution and health (free resources) AND Air Pollution and Mortality (free research and commentaries) AND Global burden of disease attributable to ambient air pollution (free report and commentaries) AND 5.5 million lives were lost in 2013 to diseases associated with Air Pollution (free report and infographic)

 


 

1 – A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology – Clinical Infectious Diseases (free)

News Release: IDSA/ASM Lab Diagnosis Guide Helps Health Care Providers Navigate Rapidly Changing Landscape of Infectious Diseases Tests, Enabling Faster, Better Treatment – Infectious Diseases Society of America (free)

 

2 – Prospective external validation of the Predicting Out-of-OFfice Blood Pressure (PROOF-BP) strategy for triaging ambulatory monitoring in the diagnosis and management of hypertension: observational cohort study – The BMJ (free)

Commentary: Reducing the need for 24-hour blood pressure monitors in general practice – University of Oxford (free)

The tool: freely available online here 

 

3 – Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study – The BMJ (free)

Commentaries: Penicillin-allergic patients may run bigger risk of MRSA, C diff – CIDRAP (free) AND Patients believed allergic to penicillin have increased risks of MRSA and C. difficile – Massachusetts General Hospital (free) AND Patients with Documented Penicillin Allergy at Higher Risk for MRSA, C. difficile – NEJM Physician’s First Watch (free)

 

4 – Perspective: Potential Policy Approaches to Address Diet-Related Diseases – JAMA (free for a limited period)

Related: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND To improve global health, tax the things that are killing us – Financial Times (free articles, commentaries and reports) AND The Lancet taskforce on NCDs and economics (free series and commentaries)

 

5 – Perspective: What’s the Best Way to Treat Normal-Weight People With Metabolic Abnormalities? – JAMA (free for a limited period)

 

6 – Guidelines for the management of osteoporosis and fragility fractures – Internal and Emergency Medicine (free)

Related Guidelines: UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free) AND Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update from the American College of Physicians – Annals of Internal Medicine (free)

 

7 – Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis – Allergy Asthma & Immunology Research (free)

 

8 – Midlife contributors to socioeconomic differences in frailty during later life: a prospective cohort study – The Lancet Public Health (free)

Commentaries: Frailty: from clinical syndrome to epidemiological construct? – The Lancet Public Health (free) AND Old before your time? Scientists have put together five warning signs middle-aged people will suffer from frailness in retirement – Daily Mail (free) AND Five modifiable risk factors found to help reach healthy old age – OnMedica (free)

Related Study: Impact of Healthy Lifestyle Factors on Life Expectancies (link to abstract and commentaries)

 

9 – Oncological outcome after MRI‐based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial – British Journal of Surgery (link to abstract – $ for full-text)

Commentaries: Many patients with rectal cancer may not need chemoradiotherapy – eCancer News (free) AND Limiting Chemo to High-Risk Rectal Cancer Called Feasible – MedPage Today (free registration required) AND OCUM Trial: Some Rectal Cancers Need Only Surgery – Medscape (free registration required)

 

10 – Study Guide: Rip Current Heroes Study Guide – National Geographic (free PDF)

News Release: Rip Current Heroes Study Guide (Free)

Videos: Rip Current Heroes (free)

Related Reports: Preventing drowning: an implementation guide – World Health Organization (free) AND Global report on drowning: preventing a leading killer – World Health Organization (free) AND Hidden Hazards: An Exploration of Open Water Drowning and Risks for Children – Safe Kids Worldwide (free PDF)

Source: Global Health NOW Newsletter

Each year they kill, on average, more lives in Australia than bushfires, floods, cyclones and sharks combined.
The global drowning prevention community is out to spread the word on identifying and escaping deadly rip currents with a public awareness campaign today. Check out a documentary and study guide focused on rip current science and survival strategies from National Geographic and Australia’s Rob Brander, a global expert in the field from UNSW Sydney”. (from Global Health NOW Newsletter)

 


 

1 – Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth – New England Journal of Medicine (free)

Commentaries: Heat-stable drug could save thousands from post-childbirth bleeding: WHO – Reuters (free) AND Saving Moms’ Lives During Childbirth Just Got Easier – NPR (free)

 

2 – Clinical Report: The Prenatal Visit – The American Academy of Pediatrics (free)

News Release: What to cover during prenatal visit: AAP clinical report offers guidance – AAP News (free)

Commentaries: Urge expectant parents to have prenatal pediatrician visit – Pediatric News (free) AND AAP updates recommendations for prenatal visits – Healio (free registration required)

 

3 – Guideline Synopsis: Management of Ventricular Arrhythmias and Sudden Cardiac Death Risk Associated With Cardiac Channelopathies – JAMA Cardiology (free for a limited period)

Original Guideline: 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death – Circulation (free PDF)

 

4 – Sex‐Specific Associations Between Alcohol Consumption and Incidence of Hypertension: A Systematic Review and Meta‐Analysis of Cohort Studies – Journal of the American Heart Association (free for a limited period)

Related Study: Effects of Repeated Binge Drinking on Blood Pressure Levels and Other Cardiovascular Health Metrics in Young Adults: National Health and Nutrition Examination Survey, 2011‐2014 – Journal of the American Heart Association (free for a limited period)

Editorial: Alcohol Consumption, Hypertension, and Cardiovascular Health Across the Life Course: There Is No Such Thing as a One‐Size‐Fits‐All Approach (free)

Commentaries: Young binge drinkers may have higher heart risks – AHA Newsroom (free) AND Alcohol Intake Tied to Elevated Blood Pressure – NEJM Physician’s First Watch (free) AND Binge drinking may increase heart risks for younger people – UPI (free)

 

5 – Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review – JAMA Dermatology (link to abstract- $ for full-text)

Commentaries: What is the Role of Diet in Psoriasis and Psoriatic Arthritis? – MedicalResearch.com (free) AND Dietary Changes Can Lessen Severity of Psoriatic Disease – Medscape (free registration required) AND Can Diet Help in Psoriasis? – MedPage Today (free registration required) AND NPF Dietary Recommendations for Psoriatic Disease – RheumNow (free)

 

6 – Perspective: FDA Repays Industry by Rushing Risky Drugs to Market – ProPublica (free)

 

7 – Society of Anesthesia and Sleep Medicine Guideline on Intraoperative Management of Adult Patients With Obstructive Sleep Apnea – Anesthesia & Analgesia (free PDF)

 

8 – Nutritional Considerations in Pediatric Pancreatitis: A Position Paper from the NASPHAN Pancreas Committee and ESPHAN Cystic Fibrosis/Pancreas Working Group – Journal of Pediatric Gastroenterology and Nutrition (free)

Commentary: Pediatric pancreatitis: nutritional care recommendations from ESPGHAN-NASPGHAN – Univadis (free registration required)

 

9 – Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Related Guideline: Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

 

10 – Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline: A Study Using Optical Coherence Tomography – JAMA Neurology (free for a limited period)

Commentaries: Eye Sign of Dementia Risk? Thinning of Retinal Nerve Fiber Layer – MedicalResearch.com (free) AND Are the Eyes Windows to Early Dementia? – MedPage Today (free registration required)

“A thinner Retinal Nerve Fiber Layer is associated with worse cognitive function in individuals without a neurodegenerative disease as well as greater likelihood of future cognitive decline”.

 


 

1 – Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Osteoporosis (free) AND Osteoporosis Screening—2 Steps May Be Too Much for Women Younger Than 65 Years (free)

Author Interview: USPSTF Recommendation Statement: Screening for Osteoporosis to Prevent Fractures (free)

See also: USPSTF Final Recommendation Statement (free)

 

2 – The Society for Vascular Surgery practice guidelines on follow-up after vascular surgery arterial procedures – Journal of Vascular Surgery (free)

 

3 – Recurrent Glioblastoma Treated with Recombinant Poliovirus – New England Journal of Medicine (free for a limited period)

Editorial: Exploiting Viruses to Treat Diseases (free for a limited period)

Commentaries: Doctors Try Genetically Modified Poliovirus As Experimental Brain Cancer Treatment – NPR (free) AND Poliovirus therapy shows early promise in patients with aggressive brain cancer but questions linger – STAT (free)

 

4 – Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care – New England Journal of Medicine (free for a limited period)

Commentaries: Improved Glycemic Control With Closed-Loop Insulin Delivery System – Endocrinology Advisor (free) AND Closed-Loop Diabetes Systems (Artificial Pancreas) Can Be Used For Inpatient Care – MedicalResearch.com (free)

 

5 – Different defibrillation strategies in survivors after out-of-hospital cardiac arrest – Heart (free)

Commentary: Onsite defibrillators helping to increase cardiac arrest survival – Reuters (free)

Related Studies: Impact of Bystander Automated External Defibrillator Use on Outcomes (free study and commentaries) AND Use of public defibrillators linked to out-of-hospital cardiac arrest survival (link to abstract and commentaries) AND Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest (link to abstract and commentaries)

 

6 – Deprescribing Proton Pump Inhibitors – Therapeutics Initiative (free)

Related guidelines: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antihyperglycemic agents in older persons: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)

 

7 – Intentional Weight Loss for Overweight and Obese Knee Osteoarthritis Patients: Is More Better? – Arthritis Care & Research (free PDF)

Commentaries: Long-term weight loss of at least 20% helps improve outcomes in overweight, obese patients with knee osteoarthritis – ACP Internist (free) AND When it comes to weight loss in overweight and obese adults with knee osteoarthritis, more is better – Wiley, via ScienceDaily (free) AND More weight loss tied to less knee pain for obese people – Reuters (free) AND More Weight Loss Linked To Greater Decrease in Knee Arthritis Pain – MedicalResearch.com (free)

 

8 – The economic cost of inadequate sleep – Sleep (free)

Commentaries: Inadequate sleep could cost countries billions – Oxford University Press USA, via EurekAlert (free) AND Wake-up call: Sleepiness ‘epidemic’ costing global economies billions – The Sidney Morning Herald (free)

 

9 – Donepezil for dementia due to Alzheimer’s disease – Cochrane Library (free)

Summary: Donepezil for people with dementia due to Alzheimer’s disease – Cochrane Library (free)

 

10 – Percutaneous Ablation Versus Partial and Radical Nephrectomy for T1a Renal Cancer: A Population-Based Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Percutaneous ablation may be preferred to nephrectomy for selected patients with early-stage renal cancer – ACP Internist (free) AND New Findings Support Ablation for Small Renal Tumors – Renal & Urology News (free)

Related Meta-Analysis: Radiofrequency ablation versus partial nephrectomy for treatment of renal masses: A systematic review and meta-analysis – The Kaohsiung Journal of Medical Sciences (free) AND Radiofrequency Ablation Versus Partial Nephrectomy in Treating Small Renal Tumors: A Systematic Review and Meta-Analysis – Medicine (free)

“Percutaneous ablation for T1a renal cancer has similar 5-year survival rates to radical nephrectomy but with far fewer 30-day complications and less kidney failure (via @AnnalsofIM see Tweet)

 


 

1 – Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences – JAMA Internal Medicine (free for a limited period)

Editorial: Hospital-at-Home Care Programs—Is the Hospital of the Future at Home? (free for a limited period)

Author Interview: Association of a Bundled Hospital-at-Home Program With Clinical Outcomes and Patient Experiences (free)

Commentaries: Hospital-at-Home Bundled Program Associated With Better Clinical Outcomes, Patient Experiences – AJMC (free) AND Clinical outcomes and patient experiences vastly improved with hospital at home – The Mont Sinai Hospital, via MedicalXpress (free) AND Hospital-at-Home Care a Potential Alternative to Inpatient Care – Physician’s First Watch (free)

 

2 – Advance care planning in dementia: recommendations for healthcare professionals – BMC Palliative Care (free)

Related: New Document for Patients: Advanced Health Directive for Dementia (free document and commentaries) AND Alzheimer’s? Your Paperwork May Not Be in Order – The New York Times (10 articles per month are free)

 

3 – Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health – International Journal of Epidemiology (link to abstract – $ for full-text)

Commentaries: Accurate measurements of sodium intake confirm relationship with mortality – ScienceDaily (free) AND Better estimate of intake more firmly links salt, death – UPI (free)

Related Report: Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks – Agency for Healthcare Research and Quality (free)

 

4 – Saline irrigation for allergic rhinitis – Cochrane Library (free)

Summary: Nasal saline for allergic rhinitis – Cochrane Library (free)

 

5 – Richard Lehman’s journal review, 25 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

6 – Update on difficult airway management with a proposal of a simplified algorithm, unified and applied to our daily clinical practice – Colombian Journal of Anesthesiology (free)

Related Guidelines: Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults – British Journal of Anaesthesia (free) AND Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway – Anesthesiology (free)

Source: Critical Care Reviews Newsletter

 

7 – Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Robotic, Open Cystectomy Offer Comparable Bladder Cancer Outcomes – Renal & Urology News (free) AND RAZOR study: No differences in robotic vs open surgery for bladder cancer – Coloproctology News (free) AND Robotic surgery is no better than traditional surgery, bladder cancer study finds – The Washington Post (free)

 

8 – A Randomized Controlled Trial of Parent-Child Psychotherapy Targeting Emotion Development for Early Childhood Depression – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Parent-Child Psychotherapy Leads to Improvements in Young Children With Depression – Psychiatric News Alert (free) AND Psychotherapeutic intervention shows promise for treating depression in preschool-aged children – NIH News Releases (free) AND Parent-child therapy helps young children with depression – Washington University School of Medicine, via ScienceDaily (free)

Related Study: Talking therapy given by parents shows promise for childhood anxiety disorders (free research, editorial and commentaries)

 

9 – Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration – JAMA (link to abstract – $ for full-text)

Commentaries: Oxygen for preterm infants, what dose of this toxic drug is the right dose? #NeoEBM – Neonatal Research (free) AND Lower and higher oxygen saturation targets result in equal but contrasting outcomes for extremely preterm infants – 2 Minute Medicine (free)

 

10 – Association Between Portable Music Player Use and Hearing Loss Among Children of School Age in the Netherlands – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)

Commentaries: Portable music players tied to hearing loss in kids – Reuters (free) AND Portable Music Player Use Linked to Hearing Loss in Children – MPR (free)

 


 

1 – Diarrhoea in adult cancer patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

2 – Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews – Cochrane Library (free)

Summary: Interventions for babies from birth to one month of life for preventing cerebral palsy: an overview of Cochrane Systematic Reviews (free)

 

3 – Prophylactic abdominal drainage for pancreatic surgery – Cochrane Library (free)

Summary: Drain use after pancreatic surgery – Cochrane Library (free)

 

4 – Resuscitation Education Science: Educational Strategies to Improve Outcomes From Cardiac Arrest: A Scientific Statement From the American Heart Association – Circulation (free PDF)

See also: Highlights (free PDF) AND FAQs (free PDF) AND Infographic (free PDF)

 

5 – Perspective: Breathing Tubes Fail to Save Many Older Patients – The New York Times (10 articles per month are free)

“One-third of patients over age 65 die in the hospital after they are put on ventilators. Doctors are beginning to wonder if the procedure should be used so often”.

 

6 – Core Competencies in Evidence-Based Practice for Health Professionals: Consensus Statement Based on a Systematic Review and Delphi Survey – JAMA Network Open (free)

Editorial: Interprofessional Evidence-Based Practice Competencies: Equalizing the Playing Field (free)

“68 core competencies for evidence-based practice for health professionals, developed using systematic review & Delphi consensus process” (via @hildabast see Tweet)

 

7 – Association of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes – JAMA (free for a limited period)

Editorial: Revisiting NPH Insulin for Type 2 Diabetes: Is a Step Back the Path Forward? (free for a limited period)

Clinical Review Audio: Health Care Spending Gone Wild: Using Expensive Insulin Analogs With Few Clinical Advantages (free)

“Long-acting insulin analogs not associated with reduced hypoglycemia-related ED visits or hospital admissions when compared with NPH insulin, despite costing 5-10x as much” (via @jsross119 see Tweet)

 

8 – Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Spotlight on albumin in cirrhosis – ACP Gastroenterology (free)

 

9 – Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: BICAR-ICU – The Bottom Line (free)

This study will reassure clinicians that already use sodium bicarbonate for correcting metabolic acidaemia, that this may delay and/or reduce the requirement for RRT. Equally, for those that opt to avoid sodium bicarbonate, there is no compelling evidence to change practice” (from The Bottom Line)

 

10 – Determinants of long-term clinical outcomes in patients with angina but without obstructive coronary artery disease: a systematic review and meta-analysis – European Heart Journal (free)

Commentaries: Outcomes in Patients With Angina but Without Obstructive CAD – American College of Cardiology (free)

 


 

1 – Report: Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks – Agency for Healthcare Research and Quality (free)

See also: Evidence Summary (free PDF) AND Full Report (free PDF)

 

2 – NICE Guideline: Hearing loss in adults: assessment and management – National Institute for Health and Care Excellence (free)

 

3 – Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials – Rheumatology (free)

Commentary: OA: DMARDs fail to relieve pain in meta-analysis – Univadis (free registration required)

 

4 – Presented at EULAR 2018: NSAIDs Account for Large Part of Osteoarthritis-CVD Link, Study Suggests – TCTMD (free)

 

5 – Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Sodium Thiosulfate for Cisplatin-Induced Hearing Loss (free)

Commentaries: New drug halves hearing loss in children following cancer treatment – Cancer Research UK, via ScienceDaily (free) AND Otoprotectant Guards Against Cisplatin-Induced Hearing Loss – Medscape (free registration required) AND Antioxidant Cuts Hearing Loss in Cisplatin-Treated Kids – MedPage Today (free registration required)

 

6 – Review: What’s new in severe pulmonary embolism? – Intensive Care Medicine (free for a limited period) (via @srrezaie)

 

7 – Perspective: This Mediterranean diet study was hugely impactful. The science just fell apart – VOX (free)

See Related Retraction and Republication: PREDIMED Study on Mediterranean Diet (free article and commentaries)

 

8 – Perspective: To Fight Burnout, Organize – New England Journal of Medicine (free)

The social determinants of health — and physicians’ sense of powerlessness in the face of them — seem crucially missing from the discussion of burnout”.

 

9 – Review: Acute myocardial infarction in young women: current perspectives – International Journal of Women’s Health (free)

Related Review: Young Women With Acute Myocardial Infarction: Current Perspectives – Circulation: Cardiovascular Quality and Outcomes (free)

Related Guideline: Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association – Circulation (free)

 

10 – Review: Managing patients with chronic cough: challenges and solutions – Therapeutics and Clinical Risk Management (free)

See also recently published CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Cough Due to TB and Other Chronic Infections  (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)

 


 

1 – Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group – World Journal of Emergency Surgery (free)

 

2 – NICE Guideline: Dementia: assessment, management and support for people living with dementia and their carers – National Institute for Health and Care Excellence (free)

 

3 – The association of lifetime alcohol use with mortality and cancer risk in older adults: A cohort study – PLOS Medicine (free)

Commentaries: Risks of cancer and mortality by average lifetime alcohol intake – PLOS, via ScienceDaily (free) AND Drinking Alcohol Can Raise Cancer Risk. How Much Is Too Much? – NPR (free) AND Light drinkers at a lower combined risk of earlier death or developing cancer – The Conversation (free) AND Expert reaction to the association between lifetime drinking and mortality and cancer risk – Science Media Centre (free)

Related Meta-analysis: Risk Thresholds for Alcohol Consumption (free study, editorial and commentaries)

 

4 – Association of Stress-Related Disorders With Subsequent Autoimmune Disease – JAMA (link to abstract – $ for full-text)

Commentaries: Association of Stress-Related Disorders With Subsequent Autoimmune Disease – University of Iceland (free) AND Stress disorders tied to increased risk of autoimmune diseases – Reuters (free) AND Does Psychological Stress Trigger Autoimmune Disorders? – MedPage Today (free registration required)

 

5 – Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort – Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentaries: Diabetes may be an early manifestation of pancreatic cancer – eCancer News (free) AND Recent-onset diabetes linked to pancreatic cancer for some minorities – UPI (free) AND Diabetes after 50 could be early sign of pancreatic cancer, study says – CNN (free)

 

6 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentary: Ebola outbreak in Congo ‘largely contained’, says WHO – Reuters (free)

 

7 – The venous ulcer continues to be a clinical challenge: an update – Burns & Trauma (free)

Related Cochrane Review: Dressings and topical agents for treating venous leg ulcers (free) AND Summary (free)

 

8 – Long-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction – JAMA Surgery (free for a limited period)

Invited Commentary: Autologous vs Prosthetic Breast Reconstruction: Where Do We Stand? (free for a limited period)

Author Interview: Long-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction (free audio)

Commentaries: Breast reconstruction more satisfying than implants after cancer, survey says – UPI (free) AND Flap vs Implant for Breast Reconstruction: How to Choose – MedPage Today (free registration required) AND Study explores satisfaction, quality of life after breast reconstruction – Brigham and Women’s Hospital, via MedicalXpress (free)

 

9 – Idiopathic intracranial hypertension: consensus guidelines on management – Journal of Neurology, Neurosurgery & Psychiatry (free) 

 

10 – Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study – Journal of Clinical Psychopharmacology (link to abstract – $ for full-text)

Commentaries: Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants – MPR (free) AND Antidepressants tied to Parkinson’s-like symptoms – Univadis (free registration required)

“Observational study: Incidence of EPSs with antidepressants. RRs: duloxetine, 5.68; mirtazapine, 3.78; citalopram, 3.47; escitalopram, 3.23; paroxetine, 3.07; sertraline, 2.57; venlafaxine, 2.37; bupropion, 2.31; and fluoxetine, 2.03 (all significant)” (via @psychopharmacol see Tweet)

 


 

1 – Clinical Review Podcast (28 min): A Goal Too Far: Rethinking HbA1c Targets for Diabetes Treatment – JAMA Internal Medicine (free)

Related: For Patients with Type 2 Diabetes, What’s the Best Target Hemoglobin A1C? (Free Commentary, ADA Position Statement and ACP Guideline)

 

2 – Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology – European Heart Journal Cardiovascular Pharmacology (free)

 

3 – Comparison of prostatic artery embolisation (PAE) versus transurethral resection of the prostate (TURP) for benign prostatic hyperplasia: randomised, open label, non-inferiority trial – The BMJ (free)

Commentary: Prostatic artery embolisation: time to improve collaboration – The BMJ Opinion (free)

 

4 – Prevalence and outcomes of incidental imaging findings: umbrella review – The BMJ (free)

Related: Giles Maskell: Incidental anarchy – The BMJ Opinion (free)

“Incidentalomas. If you order imaging studies, you know they are a problem. This meta-analysis quantifies incidentaloma prevalence for specific types of imaging. For MRI of the brain, the prevalence was 22% (95%CI 14 to 31) (via @RasoiniR and @eloder, see Tweet)

 

5 – The Impact of the National HPV Vaccination Program in England Using the Bivalent HPV Vaccine: Surveillance of Type-Specific HPV in Young Females, 2010–2016 – The Journal of Infectious Diseases (free)

Commentaries: HPV vaccine leads to steep drop in cancer-causing infections in England – CNN (free) AND HPV vaccine has almost wiped out infections in young women, figures show – The Telegraph (free)

Related Cochrane Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer (link to review and commentaries)

 

6 – Commentary: IOTA – Liberal vs Conservative Oxygen Therapy in the Critically Ill – The Bottom Line (free)

Original Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)

“Hyperoxia is BAD –> Aim for lowest safest inspired O2 in critically ill pts & titrate FiO2 down if SpO2 >95%” (via @srrezaie see Tweet)

 

7 – Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies – The Lancet Diabetes & Endocrinology (free)

Commentaries: Diabetes and cardiovascular mortality: the impact of sex – The Lancet Diabetes & Endocrinology (free) AND Diabetes triples women’s risk of death from ischemic heart disease – Cardiovascular Business (free)

 

8 – Influence of Lifestyle on Incident Cardiovascular Disease and Mortality in Patients With Diabetes Mellitus – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Healthy Lifestyle Lowers CVD Risk in Diabetes Patients – American College of Cardiology (free) AND Healthy lifestyle changes after diabetes diagnosis lower CVD risk – Cardiovascular Business (free) AND Reduction in CVD Events, Even Mortality, in Patients With Diabetes Who Adopt a Healthier Lifestyle – TCTMD (free)

 

9 – Prognostic Implications of Single-Sample Confirmatory Testing for Undiagnosed Diabetes: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Diagnosing Diabetes From a Single Blood Sample – Johns Hopkins Bloomberg School of Public Health, via NewsWise (free) AND One Blood Test Might Be Enough to Diagnosis (free) AND Diabetes Dx Predicted Accurately with Single Blood Sample – MedPage Today (free registration required) AND Diabetes Diagnoses Confirmable from Single-Sample Measurements – NEJM Physician’s First Watch (free)

“The standard practice of repeat blood tests may not always be necessary, a new study suggests” (from Johns Hopkins Bloomberg School of Public Health)

 

10 – Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis – Heart (free)

Commentaries: Marriage tied to lower risk of fatal heart attacks and strokes – Reuters (free) AND Expert reaction to study looking at marital status and risk of heart disease, stroke and death – Science Media Centre (free)

 


 

1 – Just Released! ICD-11: Classifying disease to map the way we live and die – World Health Organization (free)

See also: ICD-11 is Here! – World Health Organization (free)

Browse: ICD-11 for Mortality and Morbidity Statistics (ICD-11 MMS), 2018 version – World Health Organization (free)

 

2 – Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free)

Related: Gaming addiction classified as mental health disorder by WHO – Reuters (free) AND WHO classifies ‘gaming disorder’ as mental health condition – CNN (free)

 

3 – European Heart Rhythm Association (EHRA) consensus document on management of arrhythmias and cardiac electronic devices in the critically ill and post-surgery patient – EP Europace (free)

 

4 – State of The Art Review: Secondary peritonitis: principles of diagnosis and intervention – The BMJ (free)

 

5 – Editorial: Helping patients choose wisely – The BMJ (free)

Related: The Choosing Wisely initiative was launched 6 years ago, and now has over 550 recommendations from 18 countries (free)

See complete lists from: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia / Choosing Wisely Canada

“One of the main barriers to tackling the problem of overuse is that doctors are concerned patients will find it difficult to accept fewer interventions. However, informed patients often opt for less intervention, not more.” (via @bmj_latest see Tweet)

 

6 – Guideline: Diagnosis and Management of Gastroesophageal Reflux in Preterm Infants – Pediatrics (free)

Commentaries: AAP Issues Guidance on Reflux in Preterm Infants – Medscape (free registration required) AND Pediatrics Group Offers Tips for Managing GERD in Preterm Infants – NEJM Physician’s First Watch (free)

 

7 – Effect of Tamsulosin on Passage of Symptomatic Ureteral Stones: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Editorial: Medical Expulsive Therapy for Ureteral Stones—Stone Age Medicine (free for a limited period)

Commentaries: Recent Clinical Trial Finds Tamsulosin Not Effective in Kidney Stone Passage – George Washington University, via NewsWise (free) AND For Passing Smaller Ureteral Stones, Tamsulosin May Be No Better Than Placebo – NEJM Physician’s First Watch (free)

 

8 – Richard Lehman’s journal review, 18 June 2018 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Hip arthroscopy versus best conservative care for the treatment of femoroacetabular impingement syndrome (UK FASHIoN): a multicentre randomised controlled trial – The Lancet (free)

Commentaries: Hip arthroscopy: an evidence-based approach – The Lancet (free) AND New surgery for groin pain found to be more effective than physiotherapy – University of Warwick (free)

 

10 – European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children

Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I – Journal of the European Academy of Dermatology and Venereology (free)

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II – Journal of the European Academy of Dermatology and Venereology (free)

Commentary: New European guidelines issued for atopic dermatitis – Univadis (free registration required)

 


 

1 – British Thoracic Society Guideline for the initial outpatient management of pulmonary embolism (PE) – Thorax (free)

 

2 – Benefits and harms of screening men for abdominal aortic aneurysm in Sweden: a registry-based cohort study – The Lancet (free to abstract – $ for full-text)

Commentaries: Screening Programs for Abdominal Aortic Aneurysm Need a Rethink, Swedish Study Contends – TCTMD (free) AND Screening for aortic aneurysms in older men questioned – University of Gothemburg, via EurekAlert (free) AND Screening for Abdominal Aortic Aneurysm Questioned – NEJM Physician’s First Watch (free) AND Routine Aortic Aneurysm Screening Questioned – MedPage Today (free registration required)

 

3 – Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Does Infusion Rate Affect Neurologic Outcomes in Pediatric DKA? (free)

Commentaries: PEM Practice Changing Paper: Clinical Trial of Fluid Infusion Rates for Pediatric DKA – Aliem (free) AND The Rate of Resuscitation in Pediatric DKA – Emergency Medicine Literature of Note (free) AND Infusion Type Doesn’t Affect Brain Outcomes in Pediatric DKA – Medscape (free)

 

4 – Expert Analysis: ACS Management in a Patient in Need of Noncardiac Surgery – American College of Cardiology (free)

 

5 – Coronary Computed Tomography Angiography Versus Stress Echocardiography in Acute Chest Pain: A Randomized Controlled Trial – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentary: The Patient Presenting With Chest Pain: Stress Echo Gives Coronary CTA a Run for Its Money – TCTMD (free)

 

6 – Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs – American Academy of Neurology and the American Epilepsy Society

Part I: Treatment of new-onset epilepsy (free PDF)

Part II: Treatment-resistant epilepsy (free PDF)

Commentary: New Epilepsy Guidelines Shed Light on Explosion of New Drugs – MedPage Today (free registration required)

 

7 – Palliative Care in the Global Setting: ASCO Resource-Stratified Practice Guideline – Journal of Global Oncology (free)

Commentary: ASCO Guideline Addresses Palliative Care in the Global Setting – ASCO Daily News (free)

 

8 – Age-attuned Hospice care: An opportunity to better end of life care for older people – StCristopher’s (free PDF) (via @hospicedoctor see tweet)

“Despite the evidence that more people will die of frailty and multiple long-term conditions than of cancer, our services for those moving towards the end of their life remain focussed on the needs of the latter group”

 

9 – Caring for the caregiver: A guide for physicians – American Medical Association (free PDF)

Commentary: AMA Releases New Physician Guide on Caring for the Caregiver – The ASCO Post (free)

 

10 – Association of Perioperative Red Blood Cell Transfusions With Venous Thromboembolism in a North American Registry – JAMA Surgery (free for a limited period)

Commentary: Peri-Op RBC Transfusions Linked to Postoperative VTE – MPR (free) AND Risk for Clot Increases After Surgery With Transfusion – Medscape (free registration required) AND Post-Op VTE Risk Up After Intra-Op Blood Transfusion – MedPage Today (free registration required) AND VTE Risk Higher in Surgical Patients Who Get Transfusions – TCTMD (free)

 


 

1 – Effect of Negative Pressure Wound Therapy vs Standard Wound Management on 12-Month Disability Among Adults With Severe Open Fracture of the Lower Limb: The WOLLF Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: High-tech treatment of open leg wounds no better than using regular dressings – University of Warwick (free) AND Negative-Pressure Therapy No Better for Open Fractures – Medscape (free registration required)

“Negative pressure wound therapy did not improve 12-month disability for patients with severe open fracture of the lower limb compared with standard wound dressing”

 

2 – Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts – New England Journal of Medicine (free)

Correspondence: Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90 (free)

Commentaries: That Huge Mediterranean Diet Study Was Flawed. But Was It Wrong? – New York Times (free) AND Errors Trigger Retraction Of Study On Mediterranean Diet’s Heart Benefits – NPR (free) AND Expert reaction to retraction and republication of study looking at Mediterranean diet and heart disease – Science Media Centre (free)

 

3 – Dietary and nutritional approaches for prevention and management of type 2 diabetes – The BMJ (free)

 

4 – Perspective: The Search for Cancer Treatment Beyond Mutant-Hunting – The New York Times (10 articles per month are free)

 

5 – Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy – New England Journal of Medicine (free)

Perspective: Trolleyology and the Dengue Vaccine Dilemma – New England Journal of Medicine (free)

Commentaries: Study confirms higher risk of dengue in kids who got Sanofi vaccine – Reuters (free) AND Sanofi’s new dengue challenge: find a diagnostic that will make its vaccine safe to use – STAT (free)

 

6 – Ebola Situation Report: Ebola Virus Disease in Democratic Republic of Congo – World Health Organization (free)

Related: More suspected DRC Ebola cases amid enhanced surveillance – CIDRAP (free) AND ‘We are still at war’ with Ebola: WHO chief – Reuters (free) AND Speedy Ebola tests help contain Africa’s latest outbreak – Nature News (free)

 

7 – Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know – Critical Care (free)

 

8 – Guideline: Cancer of the upper aerodigestive tract: assessment and management in people aged 16 and over – National Institute for Health and Care Excellence (NICE) (free)

 

9 – Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline – Journal of Clinical Oncology (free)

Commentary: Mozart, meditation and a yoga mat: Oncologists welcome integrative therapies for breast cancer – eCancer News (free)

 

10 – Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension – European Heart Journal (free)

Commentaries: Dementia risk increased in 50-year-olds with blood pressure below hypertension threshold – European Society of Cardiology, via EurekAlert (free) AND Blood pressure below treatable threshold linked to heightened dementia risk – OnMedica (free) AND Studies: Higher blood pressure increases risk for dementia – UPI (free) AND High Blood Pressure at Age 50 Tied to Dementia Risk – The New York Times (10 articles per month are free) AND Dementia risk to 50-year-olds with raised blood pressure – study – The Guardian (free)

 


 

1 – Report: Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review – Agency for Healthcare Research and Quality (free)

See also: Evidence Summary (free PDF) and Full Report (free PDF)

 

2 – The WHO essential diagnostic list: a tool for the future – BMJ Global Health Blog (free)

Related: The desperate global need for medical diagnostics – The Conversation (free) AND Health care is an essential human right – and so is a proper diagnosis – The Conversation (free)

See Original WHO Report: List of Essential In Vitro Diagnostics First edition (2018) – World Health Organization (free report and news release)

 

3 – Oral Fluconazole in Pregnancy and Risk of Stillbirth and Neonatal Death – JAMA (link to abstract – $ for full-text)

Commentaries: No link found between oral antifungal drug and stillbirth – Karolinska Institutet, via ScienceDaily (free) AND Antifungal Use During Pregnancy and Risk of Stillbirth: What’s the Link? – MPR (free) AND Study Finds No Link Between Fluconazole During Pregnancy and Stillbirth or Neonatal Death – MedicalResearch.com (free) AND Oral Fluconazole for Thrush in Pregnancy Doesn’t Up Stillbirth – Medscape (free registration required)

 

4 – Controversy: Is there still a place for the Swan-Ganz catheter?

YES (free for a limited period) / NO (free for a limited period) WE ARE NOT SURE (free for a limited period)

 

5 – Draft Recommendation Statement: Unhealthy Alcohol Use in Adolescents and Adults: Screening and Behavioral Counseling Interventions – U.S. Preventive Services Task Force (free)

Commentary: USPSTF Again Recommends Screening for Unhealthy Alcohol Use in Adults – NEJM Physician’s First Watch (free)

 

6 – Flynn effect and its reversal are both environmentally caused – Proceedings of the National Academy of Sciences (link to abstract – $ for full-text)

Commentaries: Researchers find IQ scores dropping since the 1970s – MedicalXpress (free) AND IQ Scores Are Falling in “Worrying” Reversal of 20th Century Intelligence Boom – Science Alert (free) AND IQ Scores Are Falling Due to Environmental Factors, Study Finds – TIME (free)

 

7 – Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited – European Journal of Endocrinology (free)

Related Guideline: The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free)

 

8 – Review: Optimal duration of dual antiplatelet therapy for coronary artery disease – Netherlands Heart Journal (free)

Related Guidelines: 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free) AND 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)

 

9 – Invasive Procedures Associated With the Development of Infective Endocarditis – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Infective endocarditis risk increased after many types of medical procedures – ACP Hospitalist (free) AND Many Invasive Procedures, Including Cardiovascular, Up Risk of Infective Endocarditis – TCTMD (free) AND Invasive procedures—including cardiovascular—boost risk of endocarditis – Cardiovascular Business (free) AND Endocarditis: Any Invasive Procedure Is a Risk – MedPage Today (free registration required)

 

10 – Effect of Increased Inpatient Attending Physician Supervision on Medical Errors, Patient Safety, and Resident Education: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Effect of increased inpatient attending physician supervision on medical errors, patient safety, and resident education: a randomized clinical trial – PSNet (free) AND Increased attending supervision on rounds didn’t significantly reduce medical errors – ACP Hospitalist (free) AND Additional physician resident supervision doesn’t improve patient safety – Modern Healthcare (free) AND Closer Resident Supervision Does Not Reduce Medical Errors – Medscape (free registration required) AND Is More Supervision of Medical Residents Always Better for Patient Care? – MedicalResearch.com (free)

 


 

1 – Screening for Cardiovascular Disease Risk With Electrocardiography: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: The Screening ECG and Cardiac Risks (free) AND Screening for Cardiovascular Disease Risk With Electrocardiography (free)

JAMA Patient Page: Screening for Cardiovascular Disease Risk With ECG (free)

Author Interview: USPSTF Recommendation: Screening for Cardiovascular Disease Risk With Electrocardiography (free audio)

Commentaries: Doctors Told Not To Order Electrocardiograms For Low-Risk Patients – NPR (free) AND USPSTF Finds Insufficient Evidence For Preventative ECG Screening in Asymptomatic, Low-Risk Adults – American College of Cardiology (free) AND Do Not Screen Asymptomatic Adults For CVD With ECGs, Says USPSTF – TCTMD (free)

The USPSTF recommends against screening with resting or exercise electrocardiography (ECG) to prevent cardiovascular disease (CVD) events in asymptomatic adults at low risk of CVD events”.

 

2 – Prevalence of Prescription Medications With Depression as a Potential Adverse Effect Among Adults in the United States – JAMA (link to abstract – $ for full-text)

Commentaries: One-Third of US Adults May Unknowingly Use Medications That Can Cause Depression – University of Illinois at Chicago, via EurekAlert (free) AND Many U.S. adults take medicines that can cause depression – Reuters (free) AND Rx With Depression as Potential Adverse Effect Widely Used – Medscape (free registration required)

 

3 – Clinical Update: Antithrombotic Therapy for Peripheral Artery Disease in 2018 – JAMA (free for a limited period)

 

4 – Position Paper on Overdiagnosis and Action to be Taken – WONCA (free PDF) (via @RasoiniR)

Related: Overdiagnosis across medical disciplines: a scoping review – BMJ Open (free) Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free)

 

5 – The American Cancer Society public health statement on eliminating combustible tobacco use in the United States – CA: A Cancer Journal for Clinicians (free)

 

6 – A sleep prescription for medicine – The Lancet (free registration required)

“Junior doctors working a 34 h shift will make 460% more diagnostic mistakes than when well rested. Matthew Walker asks how can we change the culture of sleep within medicine?” (via @TheLancet see Tweet)

 

7 – Shaking hands is disgusting – here’s what else you can do – The Conversation (free)

Related: Handshake-free zones to prevent infections? (link to abstract and commentaries)

 

8 – Antiepileptic drugs in critically ill patients – Critical Care (free)

 

9 – Work stress and risk of death in men and women with and without cardiometabolic disease: a multicohort study – The Lancet Diabetes & Endocrinology (free)

Commentaries: Stress at work in patients with cardiometabolic disease – The Lancet Diabetes & Endocrinology (free) AND Job strain linked to heightened risk of early death in men with heart disease/diabetes – OnMedica (free) AND Work stress raises risk of premature death in vulnerable men – study – The Guardian (free) AND Job Strain as Bad as Smoking in Men With Diabetes, Heart Disease – Medscape (free registration required)

 

10 – Association of Viral Suppression With Lower AIDS-Defining and Non–AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Long-term viral suppression may help decrease cancer rates in patients with HIV – ACP Internist (free) AND Long Term HIV Viral Suppression Reduces But Does Not Eliminate Elevated Cancer Risk – MedicalResearch.com (free) AND Viral Suppression of HIV Tied to Less Cancer Risk – NEJM Physician’s First Watch (free)

 


 

1 – Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000–15 – The Lancet Global Health (free)

Commentaries: Pneumococcal and Haemophilus influenzae type b disease: moving numbers in the right direction – The Lancet Global Health (free) AND 1.35 million children’s lives saved by HiB and pneumococcal vaccines since 2000 – Johns Hopkins University Bloomberg School of Public Health, via MedicalXpress (free) AND Dramatic reduction in two killer childhood diseases, study finds – The Telegraph (free)

 

2 – A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: A Trial of Bezafibrate in Primary Biliary Cholangitis – NEJM Resident 360 (free) AND Bezafibrate Normalizes Liver Enzymes in PBC – MedPage Today (free registration required)

“In a randomized trial of patients with primary biliary cholangitis, bezafibrate and ursodeoxycholic acid resulted in a higher rate of complete biochemical response than ursodeoxycholic acid alone” (via @NEJM see Tweet with visual abstract)

 

3 – Viewpoint: Type 2 Myocardial Infarction—Diagnosis, Prognosis, and Treatment – JAMA (free for a limited period)

Related Review: Type 2 myocardial infarction due to supply–demand mismatch – Trends in Cardiovascular Medicine (free)

 

4 – Viewpoint: Progress in Prevention and Treatment of Acute Kidney Injury: Moving Beyond Kidney Attack – JAMA (free for a limited period)

 

5 – Erectile Dysfunction as an Independent Predictor of Future Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis – Circulation (free PDF)

AHA News Release: Erectile dysfunction means increased risk for heart disease, regardless of other risk factors (free)

Commentaries: Men With Erectile Dysfunction Are Twice As Likely to Have Heart Disease, Study Says – TIME (free) AND Erectile Dysfunction Linked To Higher Chances Of Heart Problems In Men – Medical Daily (free)

 

6 – pH‐neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury – The Laryngoscope (free)

Commentaries: Ingesting honey after swallowing button battery reduces injury and improves outcomes – Children’s Hospital of Philadelphia, via ScienceDaily (free) AND Honey + Sucralfate May Reduce Injury After Accidental Button Battery Ingestion – MPR (free)

 

7 – Richard Lehman’s journal review, 11 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Hydroxychloroquine: An old drug with new relevance – Cleveland Clinic Journal of Medicine (free)

Source: Hospital Medicine Virtual Journal Club

 

9 – New European Hypertension Guidelines Not in Harmony With US Guidance – TCTMD (free)

 

10 – A serious new hurdle for CRISPR: Edited cells might cause cancer, find two studies – STAT (free)

Related: Genome-editing tool could increase cancer risk – eCancer News (free) AND Gene editing tool may raise cancer risk in cells, scientists warn – Reuters (free) AND Expert reaction to using CRISPR/Cas9 and potential cancer risk in cells – Science Media Centre (free)

 


 

1 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for Anal Squamous Cell Cancers (Revised 2018) – Diseases of the Colon & Rectum (free)

 

2 – Association of Long-Term Risk of Respiratory, Allergic, and Infectious Diseases With Removal of Adenoids and Tonsils in Childhood – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)

Commentaries: Tonsillectomy in childhood raises risk of respiratory diseases – OnMedica (free) AND Tonsillectomy, Adenoidectomy in Childhood Tied to Long-Term Health Risks – Physician’s First Watch (free) AND Tonsillectomy Risks May Outweigh Benefits – The New York Times (10 articles per month are free)

 

3 – Opinion: The flu vaccine is being oversold – it’s not that effective – The Conversation (free)

See Related Cochrane Systematic Reviews: Vaccines for Preventing Influenza and Its Complications (free)

The infection rate in adults drops from 2% per year to 1%. You could say that’s halved, but it effectively only drops by 1%. So this means that out of every 100 healthy adults vaccinated, 99 get no benefit against laboratory confirmed influenza”.

 

4 – Outpatient Antibiotic Prescribing for Acute Respiratory Infections During Influenza Seasons – JAMA Network Open (free)

Commentaries: CDC study: Antibiotics still widely overused for respiratory infections – CIDRAP (free) AND Antibiotics Still Widely Prescribed for Viral ARIs – MedPage Today (free)

 

5 – High-Sensitivity Troponins and Outcomes After Myocardial Infarction – Journal of the American College of Cardiology (free for a limited period)

Commentary: High-Sensitivity Troponins and Outcomes After MI – American College of Cardiology (free) AND Advent of High-Sensitivity Troponin Tests in Sweden Leads to Only Small Uptick in MI Diagnoses – TCTMD (free)

The introduction of high-sensitive troponins was associated with an increased incidence of MI, although with no impact on survival.

 

6 – Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? – Journal of Hospital Medicine (free)

Source: Hospital Medicine Virtual Journal Club

 

7 – At one-month mark in Ebola outbreak, the focus shifts to remote areas – World Health Organization (free)

Related: WHO says Ebola situation in DRC shows promise – CIDRAP (free) AND WHO chief says Ebola outbreak in Congo is stabilizing – Reuters (free) AND An Encouraging Prediction About The Ebola Outbreak – NPR (free)

 

8 – Arrhythmia-Induced Cardiomyopathy – Deutsches Ärzteblatt international (free)

 

9 – Trends in State Suicide Rates — United States, 1999–2016 and Circumstances Contributing to Suicide — 27 States, 2015 – Centers for Disease Control and Prevention (free)

Commentaries: CDC: U.S. Suicide Rates Have Climbed Dramatically – NPR (free) AND CDC: Suicide rates rose 30% across nation since 1999 – UPI (free) AND More Americans Are Dying From Suicide – The Atlantic (free)

 

10 – Incidence of Diabetes After Cancer Development: A Korean National Cohort Study – JAMA Oncology (free for a limited period)

Commentaries: Diabetes risk increased by 9 cancers – eCancer News (free) AND Cancer Increases Risk of Developing Type 2 Diabetes, Study Finds – AJMC (free) AND Nine Cancers Linked to Diabetes Risk – Medscape (free registration required)

 


 

1 – 2018 Expert Consensus on the Management of Adverse Effects of Antiplatelet Therapy for Acute Coronary Syndrome in Taiwan – Acta Cardiologica Sinica (free)

 

2 – Building a Great Scientific Abstract: A Quick Checklist – by Hilda Bastian, in Absolutely Maybe Blog (free)

 

3 – Infographic: Global Deaths Attributable to High Systolic Blood Pressure, 1990-2016 – JAMA (free)

 

4 – Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free)

Related: University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

 

5 – Doctors Scrutinize Overtreatment, As Cancer Death Rates Decline – NPR (free)

 

6 – Community-level changes in condom use and uptake of HIV pre-exposure prophylaxis by gay and bisexual men in Melbourne and Sydney, Australia: results of repeated behavioural surveillance in 2013–17 – The Lancet HIV (free registration required)

Commentaries: Uptake of PrEP coincides with less condom use – OnMedica (free) AND PrEP uptake on the rise and condom use declines in gay men – News Medical (free) AND A pill that protects people from HIV may also lead to more sex without condoms – Science (free)

Related: How PrEP to Prevent HIV May be Fueling a Rise in Other STDs (link to abstract and commentaries)

 

7 – Education and myopia: assessing the direction of causality by mendelian randomization – The BMJ (free)

Editorial: Intense schooling linked to myopia (free)

Commentaries: Education and myopia: assessing the direction of causality by mendelian randomization – The BMJ Opinion (free) AND Myopia could be linked to longer periods spent in education – OnMedica (free) AND Highly Educated, Very Nearsighted? – The New York Times (10 articles per month are free)

 

8 – Job strain and atrial fibrillation – Results from the Swedish Longitudinal Occupational Survey of Health and meta-analysis of three studies – European Journal of Preventive Cardiology (free)

News Release: Stressful jobs are associated with a higher risk of heart rhythm disorders – European Society of Cardiology (free)

 

9 – Aspirin may be a follow-on option to prevent blood clots, starting five days after hip or knee surgery – NIHR Signal (free)

See Original Article: Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty – New England Journal of Medicine (link to abstract – $ for full-text) AND Quick Take Video Summary: Preventing VTE after Hip or Knee Arthroplasty (free)

 

10 – Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection) – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentary: UV-light cleaning shown to cut superbugs hospital-wide – CIDRAP (free)

 


 

1 – Mental Health ATLAS 2017 – World Health Organization (free PDF)

News Release: Mental health: massive scale-up of resources needed if global targets are to be met (free)

See also: WHO Campaign on Mental Health (free resources)

Every US$ 1 invested in scaling up treatment for common mental illnesses such as depression and anxiety leads to a return of US$ 4 in better health and ability to work” (via @WHO see Tweet)

 

2 – Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units – Cochrane Library (link to abstract – $ for full-text)

Summary: Interventions for preventing upper gastrointestinal bleeding in people on intensive care units – Cochrane Library (free)

Related Observational Study: H2 blockers prevented clinically important GI bleeding better than PPIs in ICU patients – ACP Hospitalist (free)

 

3 – Nicotine replacement therapy versus control for smoking cessation – Cochrane Library (free)

Summary: Can nicotine replacement therapy (NRT) help people quit smoking? – Cochrane Library (free)

 

4 – Perspective: Richard Smith: The case for medical nihilism and “gentle medicine” – The BMJ Opinion (free)

 

5 – Review: Aspiration Pneumonia and Related Syndromes – Mayo Clinic Proceedings (free)

 

6 – Ebola virus disease: Democratic Republic of the Congo – World Health Organization (free)

Related: DRC probes 5 new possible Ebola cases; WHO details experimental drugs – CIDRAP (free) AND Ebola treatments approved for compassionate use in current outbreak – World Health Organization (free) AND Ebola virus disease – Democratic Republic of the Congo: Points of Entry – World Health Organization (free)

 

7 – Stimulants for ADHD in children: Revisited – Therapeutics Initiative (via @AllenFrancesMD see Tweet)

“There is convincing evidence that a proportion of boys and girls treated with stimulants in BC and around the world are simply the youngest in their class”

 

8 – Review: Artificial Intelligence in Cardiology – Journal of the American College of Cardiology (free for a limited period)

Commentary: Reviews Examine How Digital, Mobile Advances Will Define Future of Cardiology – American College of Cardiology (free)

 

9 – Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT – Health Technology Assessment (free)

“The results of this large randomised trial, conducted in accordance with best practice, demonstrate clear benefit for antibiotic prophylaxis in terms of reducing the frequency of UTI for people carrying out CISC”.

 

10 – Association of Surgical Left Atrial Appendage Occlusion With Subsequent Stroke and Mortality Among Patients Undergoing Cardiac Surgery – JAMA (link to abstract – $ for full-text)

Commentary: Heart surgery: To have or not to have…your left atrial appendage closed – Mayo Clinic, via ScienceDaily (free) AND LAA Closure Tied to Better Heart Surgery Outcomes – MedPage Today (free registration required)

 


 

1 – Fecal Microbiota Transplantation for Primary Clostridium difficile Infection – New England Journal of Medicine (free)

Commentary: Antibiotics Weren’t Used to Cure These Patients. Fecal Bacteria Were – The New York Times (10 articles per month are free) AND The Latest Poop On Fecal Transplants Vs. Antibiotics For C. Difficile Diarrhea – Forbes (free)

 

2 – Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Study Supports Metformin Use at eGFRs as Low as 30 – NEJM Physician’s First Watch (free) AND Metformin safe for most diabetics with kidney disease – UPI (free) AND Evidence Growing Metformin Safe in Many With Diabetes and CKD – Medscape (free registration required)

Related Studies: Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease (link to abstract and commentaries) AND Metformin is linked to reduced mortality in type 2 diabetes with comorbid CKD and CHF – ACP Diabetes Monthly (free)

 

3 – #ASCO18 – Video (35 min): ASCO 2018 conference round up, by Dr Bishal Gyawali and Will Davies (free)

 

4 – #ASCO18 – Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer – New England Journal of Medicine (free)

Editorial: Endocrine Adjuvant Therapy for Localized Breast Cancer (free)

Commentary: Aromatase Inhibitor Plus Ovarian Suppression Yields Benefit in High-Risk Premenopausal Patients With Breast Cancer – The ASCO Post (free)

 

5 – Perspective: Beyond Legalization — Dilemmas Physicians Confront Regarding Aid in Dying – New England Journal of Medicine (free)

 

6 – Understanding and Improving the Health of People Who Experience Incarceration: An Overview and Synthesis – Epidemiology Reviews (free)

 

7 – Pulmonary Function Tests for the Generalist: A Brief Review – Mayo Clinic Proceedings (free)

 

8 – Catch up on new COPD guidelines – ACP Internist (free)

Original Guideline: 2018 Global Strategy for Prevention, Diagnosis and Management of COPD – Global Initiative for Chronic Obstructive Lung Disease (GOLD) (free PDF)

Pocket Guide: COPD Diagnosis, Management and Prevention (free PDF)

 

9 – Exercise for cognitive brain health in aging: A systematic review for an evaluation of dose – Neurology Clinical Practice (link to abstract – $ for full-text)

Commentary: How Much Exercise Is Needed to Help Improve Thinking Skills? – American Academy of Neurology, via NewsWise (free) AND Exercise regimen can maintain cognition in older adults, researchers say – UPI (free) AND 1-Hour Exercise, 3 Times a Week Boosts Cognition in Older Adults – MedPage Today (free registration required)

 

10 – Clinical Implications of Revised Pooled Cohort Equations for Estimating Atherosclerotic Cardiovascular Disease Risk – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: New risk calculator could change the aspirin, statins, and blood pressure medications some people take – STAT (free) AND Statin recommendations may change, especially for African-Americans – CNN (free) AND Millions could have incorrect statin, aspirin and blood pressure prescriptions – Stanford Medicine, via ScienceDaily (free)

 


 

1 – More active people for a healthier world: The global action plan on physical activity 2018 – 2030 – World Health Organization (free PDF)

News Release: More active people for a healthier world: The global action plan on physical activity 2018 – 2030 (free resources)

 

2 – Time to deliver: report of the WHO Independent High-Level Commission on Noncommunicable Diseases – World Health Organization (free PDF)

News Release: Commission calls for urgent action against chronic diseases (free)

 

3 – #ASCO18 – PREOPANC-1 Trial Compares Preoperative Chemoradiotherapy vs Immediate Surgery for Pancreatic Cancer – The ASCO Post (free)

Related Video: Pre-operative chemotherapy with radiation may help people with pancreatic cancer live longer – eCancer News (free)

 

4 – #ASCO18 – Adjuvant mFOLFIRINOX vs Gemcitabine in Resected Pancreatic Cancer – The ASCO Post (free)

Related: Pancreatic Cancer Survival Jumps With Postsurgical Chemo Combo – OncLive (free) AND Study Finds Rare Gain for Tough-To-Treat Pancreatic Cancer – Associated Press (free)

 

5 – Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders – JAMA Neurology (free for a limited period)

 

6 – Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group – Journal of the American Heart Association (free)

 

7 – The management of chronic hepatitis C: 2018 guideline update from the Canadian Association for the Study of the Liver – Canadian Medical Association Journal (free)

Commentaries: Hepatitis C guideline recommends screening for all people born 1945-1975 – CMAJ, via EurekAlert (free) AND Canadian Group Offers New Guidelines on Hepatitis C Screening, Management – NEJM Physician’s First Watch (free)

Related Guidelines: HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C – American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) (free) AND EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)

 

8 – Richard Lehman’s journal review, 4 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Optimal pharmacological therapy in ST-elevation myocardial infarction—a review – Netherlands Heart Journal (free)

Source: Critical Care Reviews Newsletter

 

10 – Eliminating Inappropriate Telemetry Monitoring: An Evidence-Based Implementation Guide – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Continuing to Improve Appropriateness of Continuous Electrocardiographic Monitoring (Telemetry) (free for a limited period)

 


 

#ASCO18 – Highlights from the American Society of Clinical Oncology Annual Meeting 2018

 

1 – #ASCO18 – Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer – New England Journal of Medicine (free)

Commentaries: 2018 ASCO: TAILORx: Most Women With Early-Stage Breast Cancer Can Forgo Chemotherapy When Guided by a Diagnostic Test – The ASCO Post (free) AND Many breast cancer patients can skip chemo, big study finds – STAT (free) AND Many women with early-stage breast cancer can skip chemotherapy: study – Reuters (free) AND For Some Breast Cancer Patients, The Chemo Decision Just Got Easier – NPR (free) AND Breast cancer: Test means fewer women will need chemotherapy – BBC (free) AND Good News for Women With Breast Cancer: Many Don’t Need Chemo – The New York Times (10 articles per month are free)

 

2 – #ASCO18 – Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study – JAMA Oncology (free)

Commentary: Increase in lifestyle-related cancers over past decade spotlights critical need for prevention – Institute for Health Metrics and Evaluation (free)

 

3 – #ASCO18 – Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma – New England Journal of Medicine (free)

Editorial: Cytoreductive Nephrectomy — Patient Selection Is Key (free)

Commentaries: 2018 ASCO: Carmena Trial Compares Nephrectomy Plus Adjuvant Sunitinib vs Sunitinib Alone in Metastatic RCC – The ASCO Post (free) AND In Advanced Kidney Cancer, Surgery No Longer Sole Standard of Care – Medscape (free registration required)

 

4 – #ASCO18 – Pembrolizumab (pembro) versus platinum-based chemotherapy (chemo) as first-line therapy for advanced/metastatic NSCLC with a PD-L1 tumor proportion score (TPS) ≥ 1%: Open-label, phase 3 KEYNOTE-042 study (link to abstract)

Commentaries: 2018 ASCO: KEYNOTE-042 Trial Compares Pembrolizumab With Chemotherapy as First-Line Treatment of NSCLC With PD-L1 Expression of 1% or More – The ASCO Post (free) AND ‘End of an Era’ for Chemo in Non-Small Cell Lung Cancer – Medscape (free registration required)

 

5 – #ASCO18 – Phase 3 Trial of Ibrutinib plus Rituximab in Waldenström’s Macroglobulinemia – New England Journal of Medicine (free)

Commentary: Ibrutinib/Rituximab Improves PFS in Waldenström’s Macroglobulinemia – ASCO Daily News (free)

 

6 – #ASCO18 – Affordability and Price Increases of New Cancer Drugs in Clinical Guidelines, 2007–2016 – Cancer Spectrum (free) (via @oncology_bg see Tweet)

 

7 – #ASCO18 – Editorial: Marketing personalized cancer treatments requires careful language – Nature (free)

Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)

“Therapies tailored to individual tumors must not be oversold”.

 

8 – #ASCO18 – 2018 ASCO: Low-Dose Maintenance Chemotherapy in Rhabdomyosarcoma – The ASCO Post (free)

 

9 – #ASCO18 – 2018 ASCO: Blood Test Shows Potential as a Detection Tool for Early-Stage Lung Cancer – The ASCO Post (free)

Commentary: Biotech Firm Grail Takes The First Steps In Its Quest For A Blood Test For Cancer – Forbes (free)

 

10 – #ASCO18 – Antibiotics greatly reduce effectiveness of cancer treatment – study – The Guardian (free) AND Antibiotics HALVE life expectancy of cancer sufferers, NHS medics reveal in world first at US conference – Daily Maily (free)

 


 

1 – World No Tobacco Day, 31 May 2018 – World Health Organization (free resources)

Related: World No Tobacco Day: Tobacco and Heart Disease – World Health Organization (free)

Commentary: Smoking down, but tobacco use still a major cause of death, disease – WHO – Reuters (free)

 

2 – Electronic cigarette use in youths: a position statement of the Forum of International Respiratory Societies – European Respiratory Journal (free)

News Release: Respiratory societies warn about electronic cigarette use in youth: World No Tobacco Day – CHEST (free)

 

3 – National, regional, and global prevalence of smoking during pregnancy in the general population: a systematic review and meta-analysis – The Lancet Global Health (free)

Invited Commentary: A global perspective on smoking during pregnancy (free)

 

4 – Cancer screening in the United States, 2018: A review of current American Cancer Society guidelines and current issues in cancer screening – CA: A Cancer Journal for Clinicians (free)

See Also Cancer Screening Guidelines from Other Organizations: U.S. Preventive Services Task Force Recommendations (all free) AND Canadian Task Force on Preventive Health Care Published Guidelines (all free)

 

5 – Clinical practice guidelines for the management of central venous catheter for critically ill patients – Journal of Emergency and Critical Care Medicine (free)

Source: Critical Care Reviews Newsletter

 

6 – Perspective by Bill Gates: Innovation for Pandemics – New England Journal of Medicine (free)

Related: The Characteristics of Pandemic Pathogens: Improving Pandemic Preparedness by Identifying the Attributes of Microorganisms Most Likely to Cause a Global Catastrophic Biological Event – Johns Hopkins Bloomberg School of Public Health (free PDF) AND Are we prepared for the looming epidemic threat? – The Guardian (free) The World Is Not Ready for the Next Pandemic – TIME cover story AND The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) AND Seven reasons we’re at more risk than ever of a global pandemic – CNN (free) AND Video: Pandemics – a worrying global public health threat (free)

 

7 – Symptomatic Zika Virus Infection in Infants, Children, and Adolescents Living in Puerto Rico – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: New studies highlight Zika presentation in kids, veterans – CIDRAP (free) AND Postnatal Zika in Kids Marked by Mild Symptoms – MedPage Today (free registration required)

 

8 – Global mental health: five key insights which emerge from the data – Our World in Data (free)

 

9 – It’s time to rethink how much booze may be too much – VOX (free)

Related Meta-Analysis: Risk Thresholds for Alcohol Consumption (free article, editorial and commentaries)

 

10 – Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study – The BMJ (free)

 


 

1 – International Expert Consensus Document on Takotsubo Syndrome: (via @JGrapsa and @TomLuscher)

Part I: Clinical Characteristics, Diagnostic Criteria, and Pathophysiology – European Heart Journal (free)

Part II: Diagnostic Workup, Outcome, and Management – European Heart Journal (free)

 

2 – Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society – CA: A Cancer Journal for Clinicians (free)

News Release: American Cancer Society Updates Colorectal Cancer Screening Guideline (free)

Commentaries: American Cancer Society recommends earlier colorectal cancer screening – Reuters (free) AND American Cancer Society advises colorectal screens at 45, not 50 – UPI (free) AND Cancer Group Calls for Colorectal Cancer Screening Starting at Age 45 – The New York Times (10 articles per month are free) AND Get Screened Earlier For Colorectal Cancer, Urges American Cancer Society – NPR (free)

Related Guidelines (all suggest screening should begin at age 50 years in average-risk individuals): Colorectal Cancer Screening – U.S. Preventive Services Task Force (free resources) AND Recommendations on screening for colorectal cancer in primary care – Canadian Task Force on Preventive Health Care (free) AND Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer – The American Journal of Gastroenterology (free)

 

3 – Type 2 diabetes mellitus in older people: a brief statement of key principles of modern day management including the assessment of frailty. A national collaborative stakeholder initiative – Diabetic Medicine (free)

Commentary: New guidance on treating diabetes in elderly and frail adults – University of Exeter, via EurekAlert (free)

 

4 – Diabetes Canada Position Statement for People with Types 1 and 2 Diabetes Who Fast During Ramadan – Canadian Journal of Diabetes (free)

 

5 – For Patients With Type 2 Diabetes, What’s the Best Target Hemoglobin A1C? – JAMA (free for a limited period)

Related: A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks – Diabetes Care (free) AND Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)

 

6 – Things We Do For No Reason: Neutropenic Diet – Journal of Hospital Medicine (free) (via @guptaarjun90 and @AnilMakam)

 

7 – Sugar, tobacco, and alcohol taxes to achieve the SDGs – The Lancet (free registration required)

Commentary: Sugar, tobacco, and alcohol taxes to achieve the Sustainable Development Goals – London School of Hygiene & Tropical Medicine (free)

Related: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND To improve global health, tax the things that are killing us (free articles, commentaries and reports) AND The Lancet taskforce on NCDs and economics (free series and commentaries)

 

8 – Ebola vaccine provides protection and hope for high-risk communities in the Democratic Republic of the Congo – World Health Organization (free)

Related: Ebola cases drop as more specimens test negative – CIDRAP (free)

 

9 – Intake of Different Dietary Proteins and Risk of Heart Failure in Men – Circulation (free)

Commentaries: High protein diet associated with small increased heart failure risk in middle-aged men – AHA Newsroom (free) AND High-Protein Diets May Slightly Increase The Risk Of Heart Disease – Forbes (free)

 

10 – Lifetime Smoking History and Risk of Lung Cancer: Results From the Framingham Heart Study – Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentaries: Risk of Incident Lung Cancer Drops by 39% Five Years After Smokers Quit – AJMC (free) AND New research finds lung cancer risk drops substantially within five years of quitting – Vanderbilt University Medical Center, via eCancer News (free)

 


 

1 – Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists – Annals of Oncology (free)

Commentaries: AI surpasses dermatologists at diagnosing skin cancer – ESMO, via eCancer News (free) AND Computer learns to detect skin cancer more accurately than doctors – The Guardian (free) AND A.I. better at diagnosing skin cancer than humans – OnMedica (free)

 

2 – It Saves Lives. It Can Save Money. So Why Aren’t We Spending More on Public Health? – The New York Times (10 articles per month are free)

Related: Return on investment of public health interventions: a systematic review – Journal of Epidemiology & Public Health (free)

Source: Global Health NOW Newsletter

 

3 – How is the world doing in its fight against vaccine preventable diseases? – Our World in Data (free)

“Vaccines are amazing: the number of child deaths caused by diseases for which vaccines are available fell by over 2/3 in 25 years. 3.6 million(!) fewer kids under the age of 5 died from these diseases in 2015 than in 1990” (via @DinaPomeranz see Tweet)

 

4 – Viewpoint: Big Data and Predictive Analytics: Recalibrating Expectations – JAMA (free for a limited period)

 

5 – Richard Lehman’s journal review, 29 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

6 – Has suicide become an occupational hazard of practicing medicine? – CMAJ News (free)

Related: Preventing physician suicide – ACP Hospitalist (free) AND What I’ve learned from my tally of 757 doctor suicides – The Washington Post (free) AND Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT (free) AND Protecting interns and other physicians from depression and suicide – STAT (free)

“Our work environments are unhealthy and it’s supported by a culture of giving and made worse in modern times by a culture of efficiencies and bureaucracies”

 

7 – The Endless Days Of A Young Doctor Battling Ebola – NPR (free)

Other Stories on the Ebola Outbreak: Ebola outbreak response shifts to remote DRC hot spots – CIDRAP (free) AND New Ebola Outbreak in Africa Is a Major Test for the WHO – JAMA Forum (free) AND WHO’s Congo Ebola plan assumes 100-300 cases over three months – Reuters (free) AND Ebola outbreak 2018: What’s different this time? – CNN (free) AND More regions to be vaccinated, experimental drugs to be tried in Congo Ebola outbreak – CNN (free)

 

8 – Association of State Alcohol Policies With Alcohol-Related Motor Vehicle Crash Fatalities Among US Adults – JAMA Internal Medicine (free for a limited period)

Editorial: Effective Alcohol Policies—Saving Lives on US Roadways (free)

Commentary: Stricter state alcohol access rules can save 800 DUI deaths a year, study says – CNN (free) AND Stronger alcohol policies help reduce alcohol-related crash deaths in US – Boston University, via EurekAlert (free)

 

9 – Unfinished Journey: The Global Health Response to Children & Road Traffic – FIA Foundation (free PDF)

News Release: Call for urgent action as ‘fatal disconnect’ in global health policies fails child victims of road traffic (free)

Source: International Health Policies Newsletter

 

10 – Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free)

Editorial: Prenatal Vitamin D Supplementation to Improve Health in Offspring (free)

Commentary: Vitamin D Supplementation of Moms Linked to Better Outcomes for Newborns – Physician’s First Watch (free)

 


 

1 – Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)

See also: NEJM Tweet with visual abstract

There is something very disturbing about a trial with HR=0.76, 95% CI 0.55-1.04 for the primary endpoint being stopped early for futility”. This TWEETORIAL by @ADAlthousePhD is a huge help in interpreting the results of this important trial (see more on the rise of “Tweetorial” here).

 

2 – Review: Supplemental Vitamins and Minerals for CVD Prevention and Treatment – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Most vitamin, mineral supplements not shown to lower heart disease risk – American College of Cardiology, via ScienceDaily (free) AND Aside From Folate, Vitamins Appear Largely Ineffective For Prevention, Study Finds – Forbes (free) AND Most popular vitamin and mineral supplements provide no health benefit, study finds – St. Michael’s Hospital, via EurekAlert (free)

 

3 – Perspective: Incidental anarchy – The BMJ Opinion (free)

“Giles Maskell writes on over diagnosis and underdiagnosis, the complexities of incidental findings and urges clinicians to “Think before you scan because you can” (via @bmj_latest see Tweet)

 

4 – Review: Management of cardiogenic shock complicating myocardial infarction – Intensive Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

 

5 – Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology – European Journal of Heart Failure (free PDF)

 

6 – Women’s Health Policy in the United States: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

Commentary: U.S. doctors call for health policies that support women – Reuters (free)

 

7 – Concomitant fibromyalgia complicating chronic inflammatory arthritis: a systematic review and meta-analysis – Rheumatology (free)

Commentary: Comorbid fibromyalgia common in patients with inflammatory arthritis – MedwireNews (free)

 

8 – How common is alcohol and drug dependency across the world? – Our World in Data (free)

 

9 – Online Atlas: The 2018 Atlas of Sustainable Development Goals – The World Bank (free)

Download PDF: The 2018 Atlas of Sustainable Development Goals – The World Bank (free)

News Release: The 2018 Atlas of Sustainable Development Goals: an all-new visual guide to data and development (free)

 

10 – World Health Organization-World Federation of Societies of Anaesthesiologists (WHO-WFSA) International Standards for a Safe Practice of Anesthesia – Canadian Journal of Anesthesia (free)

Commentaries: International anesthesia standards updated with WHO in global effort to improve surgical care – World Health Organization-World Federation of Societies of Anaesthesiologists, via EurekAlert (free)

 


 

1 – HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C – American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) (free)

News Release: HCV Guidance Updates Recommendations for Screening and Treating Key Populations (free)

Related Guideline: EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)

 

2 – A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks – Diabetes Care (free) (via @Abraham_RMI)

Related guideline: Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)

 “Clinicians should aim to achieve an HbA1c level between 7% and 8% in most patients with type 2 diabetes” (from ACP Guideline, prompting the Editorial)

 

3 – Latest Developments on the Ebola Outbreak in DRC:

Vaccinations set to begin in Ebola outbreak epicenter – STAT (free) AND Research during Ebola vaccine trial: It’s complicated – Science (free) AND New Ebola Tactics Raise Hope but May Sow Confusion – The New York Times (10 articles per month are free) AND Ebola outbreak in DRC on ‘epidemiological knife-edge,’ says WHO official – Devex (free) AND The success of the new Ebola vaccine will hinge on trust – VOX (free)

 

4 – Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy – Annals of Intensive Care (free) (via @Fluid_Academy)

Related Review: Expert statement for the management of hypovolemia in sepsis – Intensive Care Medicine (free)

 

5 – Perspective: QALYs in 2018—Advantages and Concerns – JAMA (free for a limited period)

 

6 – Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments: A Scientific Statement From the American Heart Association (free PDF)

Commentary: Appreciating Cardiovascular Disease Risk in South Asians: The Time is Now (free)

Top Ten Things to Know: Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments (free PDF)

AHA News: South Asians’ high risk of cardiovascular disease has been hidden by a lack of data (free)

News Release: South Asian Americans are at high risk for heart disease and stroke (free)

 

7 – Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study – JAMA Neurology (free for a limited period)

Commentaries: Vascular risk interacts with amyloid levels to increase age-related cognitive decline – Massachusetts General Hospital, via ScienceDaily (free) AND Bad Synergy—Together, Vascular Problems and Aβ Hasten Memory Slippage – AlzForum (free) AND Combo of vascular risk, brain amyloid could quicken mental decline – Cardiovascular Business (free)

 

8 – Association of Low-Fat Dietary Pattern With Breast Cancer Overall Survival: A Secondary Analysis of the Women’s Health Initiative Randomized Clinical Trial – JAMA Oncology (free)

Commentaries: Low-fat Diet May Improve Overall Survival in Newly Diagnosed Breast Cancer – Oncology Nurse Advisor (free) AND Low-fat diet reduces risk of breast cancer death – NHS Choices (free)

 

9 – Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study – The BMJ (free)

Editorial: Antidepressant induced weight gain (free)

Commentaries: Antidepressant therapy and risk of weight gain – The BMJ Opinion (free) AND Taking antidepressants could be linked to weight gain, according to a new study — and some drugs heighten the risk more than others – Business Insider (free) AND Antidepressants linked to risk of weight gain, study shows – OnMedica (free) AND Antidepressant use linked with weight gain – NHS Choices (free)

 

10 – Committee Opinion: Gynecologic Care for Adolescents and Young Women With Eating Disorders – American College of Obstetricians and Gynecologists (free)

News Release: Ob-Gyns Have Important Role on Care Team for Women with Eating Disorders – ACOG (free)

Commentary: OB/GYN Group Offers Advice on Caring for Teens, Young Women with Eating Disorders – Physician’s First Watch (free)

 


 

1 – Report: Diet, Nutrition, Physical Activity and Cancer: a Global Perspective – World Cancer Research Fund (free)

Commentaries: A blueprint to beat cancer – World Cancer Research Fund (free) AND 10-year study shows obesity increases risk for 12 cancers – UPI (free)

 

2 – Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Related Guideline: Pancreatic cancer in adults: diagnosis and management – National Institute for Health and Care Excellence (free)

Related Systematic Review: Chemotherapy and radiotherapy for advanced pancreatic cancer – Cochrane Library (free)

 

3 – Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Suspected Acute Venous Thromboembolic Disease – American College of Emergency Physicians (free)

Summary: ACEP Clinical Policy on Acute VTE 2018 – R.E.BE.L.em (free)

Related: Should We Anticoagulate Patients with Isolated Subsegmental Pulmonary Emboli? – NEJM Journal Watch (free)

 

4 – Review: The art of cardiovascular risk assessment – Clinical Cardiology (free)

 

5 – Review: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults – European Journal of Endocrinology (free)

 

6 – Europe’s open-access drive escalates as university stand-offs spread – Nature News (free)

 

7 – Perspective: How Tech Can Turn Doctors Into Clerical Workers – The New York Times Magazine (10 articles per month are free)

“The threat that electronic health records and machine learning pose to physicians’ clinical judgment — and their well-being”.

 

8 – New Free Online Course: Introduction to Critical Care Medicine – University of Glasgow and FutureLearn (free) (via @classcentral)

 

9 – Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study – The BMJ (free)

Editorial: Atopic eczema and cardiovascular disease (free)

Commentaries: Severe eczema and increased risk of cardiovascular problems – The BMJ Opinion (free) AND Severe eczema linked to cardiovascular problems – OnMedica (free) AND People with severe eczema at higher risk of heart conditions – NHS Choices (free)

 

10 – Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women – Journal of the American Heart Association (free for a limited period)

Editorial: Cardiovascular Sequels of Hypertension in Pregnancy (free for a limited period)

Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries)

 


 

1 – A Pragmatic Trial of E-Cigarettes, Incentives, and Drugs for Smoking Cessation – New England Journal of Medicine (free)

Commentaries: Money a better motivator to stop smoking than free e-cigs or quit aids – Reuters (free) AND E-cigarettes aren’t better at helping smokers quit than other strategies – Journalist’s Resource (free) AND For Smoking Cessation, Money Whispers Louder than Nicotine Replacement – MedPage Today (free registration required)

“Trial finds financial incentives most effective – but nothing very effective” (from MedPage Today)

 

2 – A Randomized Trial of a Family-Support Intervention in Intensive Care Units – New England Journal of Medicine (free)

Editorial: Nurse-Led Communication in the Intensive Care Unit (free)

Commentary: Team Approach to Support Families Improves ICU Patient-Centered Care and Lowers Costs – University of Pittsburg (free)

 

3 – Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology – Journal of Clinical Oncology (free)

 

4 – Advocating for Life Support Training of Children, Parents, Caregivers, School Personnel, and the Public – Pediatrics (free)

Summary: Advocating for Life Support Training of Children, Parents, Caregivers, School Personnel, and the Public (free)

News Release: AAP policy says more people need access to life support training, AEDs (free)

Commentary: AAP: Children can be educated in assisting those in cardiac arrest – Healio (free registration required)

 

5 – Estimating the Association of the 2017 and 2014 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults: An Analysis of National Data – JAMA Cardiology (free for a limited period)

Author Interview: Association of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults (free)

Commentary: Under 2017 Guideline, More Than 105 Million Americans Have Hypertension – AJMC (free)

The researchers estimated risk reductions of CVD and all-cause mortality, as well as associated harms from therapy, assuming the entire US adult population achieved guideline-recommended systolic BP treatment goals.

 

6 – Perspective: Ten dubious beliefs in neurocritical care – PulmCrit (free)

 

7 – A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill – Critical Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

 

8 – Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial – The Lancet (link to abstract – $ for full-text)

Related Article: Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial (link to abstract – $ for full-text)

Commentaries: Two Sham-Controlled Renal Denervation Studies Offer Hope in Hypertension – TCTMD (free) AND Renal denervation linked to significant drops in blood pressure – Cardiovascular Business (free) AND Novel Renal Denervation Catheters Showing Modest BP Reductions – MedPage Today (free registration required)

 

9 – Incidence and cost of medication harm in older adults following hospital discharge: A multicentre prospective study in the UK – British Journal of Clinical Pharmacy (free PDF)

Commentaries: Medication-related harm is common in older adults after hospital discharge – OnMedica (free) AND Medication-related harm found to be common among older adults, but preventable  – News Medical (free)

 

10 – Using alternatives to the car and risk of all-cause, cardiovascular and cancer mortality – Heart (free)

Commentaries: Avoiding the car for travel could significantly lower risk of illness and death – BMJ, via EurekAlert (free) AND Ditching the car may reduce your risk of dying from heart disease and stroke by almost a third – The Conversation (free)

 


 

1 – Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection – New England Journal of Medicine (free)

Commentaries: Procalcitonin-Guided Care Doesn’t Reduce Antibiotics for Lower Respiratory Tract Infection – NEJM Journal Watch (free) AND Infection blood test of limited value in reducing antibiotic use – MedicalXpress (free)

 

2 – Joint statement from the American College of Surgeons Committee on Trauma (ACS COT) and the American College of Emergency Physicians (ACEP) regarding the clinical use of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) (free)

Commentary: EMCrit Guest Post – The good, the bad, and the ugly of the Joint Statement on REBOA by Zaffer Qasim (free)

Source: Critical Care Reviews Newsletter

 

3 – Committee Opinion: Postpartum Pain Management – American College of Obstetricians and Gynecologists (free)

News Release: ACOG Recommends Postpartum Pain Management Approach Tailored to Patients (free)

Commentaries: ACOG: Postpartum Pain Management Requires Individualized Approach – MedPage Today (free registration required) AND OB/GYN Group Releases Guidance on Managing Postpartum Pain – NEJM Physician’s First Watch (free)

 

4 – WHO supports Ebola vaccination of high risk populations in the Democratic Republic of the Congo – World Health Organization (free)

Commentaries: Experimental Ebola Vaccinations, Considered ‘Paradigm Shift,’ Begin In Congo – NPR (free) AND Ebola vaccine drive launches in DRC as cases rise to 49 – CIDRAP (free) AND Congo begins giving experimental Ebola vaccine to medics – Reuters (free)

See also: Frequently asked questions on Ebola virus disease vaccine – World Health Organization (free)

“Health workers operating in affected areas in the Democratic Republic of the Congo are being vaccinated today and community outreach has started to prepare for the ring vaccination” (via @WHO see Tweet)

 

5 – Health care is an essential human right – and so is a proper diagnosis – The Conversation (free)

Related Commentary: For First Time, W.H.O. Names Some Lab Tests ‘Essential’ – The New York Times (10 articles per month are free)

See Original WHO Report: List of Essential In Vitro Diagnostics First edition (2018) – World Health Organization (free report and news release)

 

6 – Review: Autism spectrum disorder: advances in diagnosis and evaluation – The BMJ (free for a limited period)

 

7 – Opinion: Don’t Put That in My Heart Until You’re Sure It Really Works – The New York Times (10 articles per month are free)

Commentary: Cardiologist wants more rigorous testing before devices, techniques are adopted – Cardiovascular Business (free)

See also: Commentaries (PRO and Con) on the CABANA Trial (all free)

 

8 – Richard Lehman’s weekly journal review, 21 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Review: Identifying and managing depression in patients with coronary artery disease – Journal of the American Academy of Pas (free)

Commentaries: Depression in Patients With CAD – American College of Cardiology (free) AND Early Depression Diagnosis is Deadly Serious for Patients with Coronary Artery Disease – Florida State University, via NewsWise (free)

 

10 – Association of Burden of Atrial Fibrillation With Risk of Ischemic Stroke in Adults With Paroxysmal Atrial Fibrillation: The KP-RHYTHM Study – JAMA Cardiology (free)

Commentaries: Atrial Fibrillation Burden and Stroke Risk – American College of Cardiology (free) AND Greater burden of atrial fibrillation linked to higher stroke risk – Kaiser Permanente, via EurekAlert (free)

 


 

1 – Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis – Critical Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

“In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced”.

 

2 – Aldosterone Antagonist Therapy and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Without Heart Failure: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Mineralocorticoid Receptor Antagonists in ST-Segment Elevation Myocardial Infarction – JAMA Internal Medicine (free for a limited period)

Aldosterone antagonists are beneficial for patients with STEMI and reduced ejection fraction. This meta-analysis suggests that patients with STEMI and LVEF greater than 40% or without heart failure also have improved outcomes with aldosterone antagonists.

 

3 – Effect of More vs Less Frequent Follow-up Testing on Overall and Colorectal Cancer–Specific Mortality in Patients With Stage II or III Colorectal Cancer: The COLOFOL Randomized Clinical Trial – JAMA (free for a limited period)

Related Trial: Association Between Intensity of Posttreatment Surveillance Testing and Detection of Recurrence in Patients With Colorectal Cancer (free for a limited period)

Commentaries: Surveillance intensity not associated with earlier detection of recurrence or improved survival in colorectal cancer – MedicalXpress (free) AND CRC: No Increase in Survival with Stepped-Up Surveillance – MedPage Today (free registration required) AND CRC recurrence surveillance studies: No benefit to high-intensity strategy – Oncology Practice (free)

 

4 – Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma – New England Journal of Medicine (free)

Related Article: Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma – New England Journal of Medicine (free)

Editorial: New Biologics for Asthma (free)

Commentary: Dupilumab Improves Severe Asthma – NEJM Physician’s First Watch (free)

 

5 – Five-Year Outcomes with PCI Guided by Fractional Flow Reserve – New England Journal of Medicine (free)

Commentary: FFR in PCI for Stable CAD: Lasting Benefit Shown by FAME 2, SCAAR Data – TCTMD (free)

 

6 – Pro/Con Debate: CTA as the Initial Test in Stable Angina – American College of Cardiology

Pro: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)

Con: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)

 

7 – How PrEP, the pill to prevent HIV, may be fueling a rise in other STDs – Vox (free)

Original Meta-Analysis: Effects of Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection on Sexual Risk Behavior in Men Who Have Sex With Men: A Systematic Review and Meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

See also: Guidelines on HIV Pre-exposure Prophylaxis (all free)

 

8 – Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults – Heart (free)

Commentaries: BMJ’s scrambled message on eggs and heart disease: a recipe for rotten news coverage – Health News Review (free) AND Expert reaction to eggs and CVD – Science Media Centre (free) AND No, Eating Eggs Will NOT Protect You From Cardiovascular Death – The Methods Man (free)

 

9 – Rapid Recommendations: Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline – The BMJ (free)

“We issue a strong recommendation for use of atraumatic needles in all patients (adults and children) undergoing lumbar puncture because they decrease complications and are no less likely to work than conventional needles”

 

10 – New BMJ Series: Universal Health Coverage

The BMJ in partnership with The Harvard Global Health Institute are launching a collection of articles that will explore how to achieve effective Universal Health Coverage (UHC)”

Analysis: Rethinking assumptions about delivery of healthcare: implications for universal health coverage (free)

Opinion: Non-communicable diseases must be part of Universal Health Coverage (free)

Opinion: Ensuring effective investments in Universal Health Coverage at the national level (free)

Opinion: Paying and investing in community health workers accelerates universal health coverage (free)

 


 

1 – Outbreaks Associated with Treated Recreational Water — United States, 2000–2014 – MMWR, CDC (free)

Commentaries: Hotel pools a factor in water-related illness outbreaks – CIDRAP (free) AND Crypto, Pseudomonas and Legionella responsible for most outbreaks in swimming venues – Outbreak News Today (free) AND Sparkling Pool Water May Hold Disease-Causing Parasites – The New York Times (10 articles per month are free) AND CDC: How To Avoid Getting Sick From A Hotel Swimming Pool – Forbes (free)

 

2 – May Measurement Month 2017: an analysis of blood pressure screening results worldwide – The Lancet Global Health (free)

Commentary: One in Three Have Hypertension – AJP (free)

What do we learn from checking blood pressure in >1.2 million people of 80 countries who have not had their BP measured in a year? 34% HTN, 46% not controlled, Saturday spikes and a lot more” (via @EricTopol see Tweet)

 

3 – Perspective: Trying to Put a Value on the Doctor-Patient Relationship – The New York Times Magazine (10 articles per month are free)

“In its push for profits, the U.S. health care system has made it difficult for patients to get personal attention from doctors. But what if hands-on medicine actually saves money — and lives?”

 

4 – E-cigarettes: A win or loss for public health? – Knowable Magazine (free)

Related Perspective: The Promise of Vaping and the Rise of Juul – The New Yorker (free)

See also: related guidelines, reports and commentaries on e-cigarettes (all free)

“Arguments over whether e-cigarettes are harmful or helpful seem gridlocked as emerging research underscores both the toxicity of vaping and its possible benefits”. (via @ghn_news see Tweet)

 

5 – Dose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized, Double-Blind Trials – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)

Commentary: Depression: boosting SSRIs doesn’t work – Univadis (free registration required)

“Meta-analysis: there is evidence from RCTs against increasing the dose of SSRIs (with the possible exception of citalopram) in adult patients with major depression and antidepressant treatment failure” (via @psychopharmacol see Tweet)

 

6 – Statement on the 1st meeting of the IHR Emergency Committee regarding the Ebola outbreak in 2018 – World Health Organization (free)

Commentaries: WHO: Ebola in DRC not global emergency; ring vaccination starts in 2 days – CIDRAP (free) AND Ebola outbreak is concerning, but falls short of global emergency, WHO panel says – STAT (free)

 

7 – Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients With Difficult Airways Undergoing Emergency Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: JC: Don’t blame it on the Bougie – St Emlyn’s (free) AND EM Nerd-The Peculiar Case of the Parallel Pathways – EmNerd (free) AND The humble bougie markedly boosts first-pass intubation success – Univadis (free registration required)

 

8 – Risk of suicide following an alcohol-related emergency hospital admission: An electronic cohort study of 2.8 million people – PLOS One (free)

Commentaries: Emergency hospital admissions for alcohol a red flag for suicide risk – new study – Public Health Wales (free) AND Alcohol-Related Emergency Admissions: A Marker for Suicide Risk – NEJM Journal Watch (free for a limited period)

 

9 – Report: World Health Statistics 2018: Monitoring health for the SDGs – World Health Organization (free)

Commentary: World Health Statistics: Over Half Of World’s Population Lack Essential Healthcare – WHO – Vigil 360 (free)

 

10 – Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease: A Science Advisory From the American Heart Association – Circulation (free PDF)

News Release: Keep saying yes to fish twice a week for heart health (free)

AHA News: Eating fish twice a week reduces heart, stroke risk (free)

Commentary: Omega-3 Fatty Acids and Coronary Heart Disease: A Very Fishy Story (free)

Top Ten Things to Know: Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease (free PDF)

 


 

1 – Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Inhaled Combined Therapy as Needed in Mild Asthma (free)

Related Trial: As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: International Study Suggests Alternative Treatment for Mild Asthma – McMaster University, via NewsWise (free) AND On Demand as Effective as Maintenance Therapy for Mild Asthma – Medscape (free registration required)

 

2 – Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial – The BMJ (free)

Commentaries: Exercise Doesn’t Slow Cognitive Decline in Patients with Dementia – NEJM Physician’s First Watch (free) AND Rigorous exercise does not halt dementia decline, study concludes – The Guardian (free) AND Expert reaction to effects of exercise on dementia in old people – Science Media Centre (free) AND Exercise ‘doesn’t slow’ progression of dementia – NHS Choices (free)

 

3 – WHO concerned as one Ebola case confirmed in urban area of Democratic Republic of the Congo – World Health Organization (free)

Commentaries: As Ebola hits major DRC city, WHO convenes emergency panel – CIDRAP (free) AND WHO to weigh declaration of international emergency over Ebola outbreak – STAT (free) AND Congo and WHO race to prevent runaway Ebola outbreak – Reuters (free) AND Fears of Larger Contagion as Ebola Spreads to Major Congo City  The New York Times (10 articles per month are free)

 

4 – Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank – The Lancet Psychiatry (link to abstract – for full-text)

Commentaries: Disrupted sleep-wake cycle linked to mental health problems – new study – The Conversation (free) AND Study: Body clock disruption linked to mood disorders – UPI (free) AND Body clock disruptions linked to mood disorders – NHS Choices (free) AND Maintaining a daily rhythm is important for mental health, study suggests – CNN (free)

 

5 – Psychological therapies for treatment-resistant depression in adults – Cochrane Library (free)

Summary: Are psychological therapies effective in treating depression that did not get better with previous treatment? – Cochrane Library (free)

 

6 – Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes – JAMA Neurology (free for a limited period)

Commentaries: Peripheral Neuropathy Common in Childhood Cancer Survivors – MPR (free) AND Chemo-Induced Neuropathy Common after Childhood Cancer – MedPage Today (free registration required)

 

7 – Opinion: The ten pitfalls of lactate clearance in sepsis – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

 

8 – Executive summary of the Clinical Guidelines of Pharmacotherapy for Neuropathic Pain: second edition by the Japanese Society of Pain Clinicians – Journal of Anesthesia (free)

 

9 – Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract – European Heart Journal (free)

Commentary: EAS Consensus Document Examines Safety of Statins Beyond Muscle Symptoms – TCTMD (free)

 

10 – Summary: The Practice of Cardio-Oncology in Spain: Position Statement From Scientific Societies Involved in Cancer and Heart Disease – American College of Cardiology (free)

Original Guideline: Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)

 


 

#ESOC2018 – Highlights from the 4th European Stroke Organization Conference

 

1 – #ESOC2018 – Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial – The Lancet (free)

Editorial: Haemostatic treatment for intracerebral haemorrhage (free)

Commentaries: Study: Drug to treat bleeding may reduce stroke deaths – UPI (free) AND Drug to treat bleeding may benefit some stroke patients, study finds – University of Nottingham, via EurekAlert (free)

 

2 – #ESOC2018 – Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (free)

Editorial: Antiplatelet Therapy after Ischemic Stroke or TIA (free)

Commentary: Dual Antiplatelet Therapy or Aspirin Alone After TIA or Minor Stroke? – NEJM Physician’s First Watch (free)

 

3 – #ESOC2018 – MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset – New England Journal of Medicine (free)

Editorial: MRI-Guided Intravenous Alteplase for Stroke — Still Stuck in Time (free)

Commentary: New treatment option for ‘wake-up’ stroke patients – University of Glasgow, via MedicalXpress (free)

 

4 – #ESOC2018 – Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source – New England Journal of Medicine (free)

Commentaries: NAVIGATE ESUS: Rivaroxaban Fails to Prevent More Recurrent Cryptogenic Strokes Than Aspirin – TCTMD (free) AND Rivaroxaban Not Superior to Aspirin for Patients with Embolic Stroke of Unknown Source – NEJM Physician’s First Watch (free)

 

5 – #ESOC2018 – Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke – New England Journal of Medicine (free)

Commentaries: Elevated Stroke Risk Continues for 5 Years After TIA – NEJM Physician’s First Watch (free) AND Five Years after TIA or Minor Stroke, Second-Event Risk Persists – MedPage Today (free)

 

6 – Manual: Managing epidemics: Key facts about major deadly diseases – World Health Organization (free)

“Managing epidemics. This @WHO manual provides concise, up-to-date knowledge on 15 infectious diseases that have the potential to become international threats, and tips on how to respond to each of them”. (via @Onisillos and @claireekt see Tweet)

 

7 – Report: Saving lives, spending less: a strategic response to noncommunicable diseases – World Health Organization (free PDF)

News Release: Investing in noncommunicable disease control generates major financial and health gains – World Health Organization (free)

“For every US$1 invested in each policy area, the following returns have been documented:

US$12.82 from promoting healthy diets

US$9.13 from reducing the harmful use of alcohol

US$7.43 from lower tobacco use

US$3.29 from providing drug therapy for cardiovascular disease

US$2.80 from increasing physical activity

US$2.74 from managing cancer”

 

8 – ASCO 2018: Shortening Adjuvant Trastuzumab to 6 Months in Patients With HER2-Positive Early Breast Cancer Is Effective and Reduces Cardiac Toxicities – The ASCO Post (free)

Commentaries: Test of Herceptin Finds Briefer Treatment Can Work, With Fewer Side Effects – NPR (free) AND Shorter drug treatment OK for many breast cancer patients – Associated Press (free) AND For Women With Early Breast Cancer, Herceptin Treatment Can Be Much Shorter – The New York Times (10 articles per month are free)

““For women with early-stage breast cancer who needed the drug Herceptin, 6 months of treatment were as good as 12, a major study found. Less risk of side effects, less cost, less time “being a patient.”” (via @NYTHealth see Tweet)

 

9 – Global Burden of Multiple Myeloma: A Systematic Analysis for the Global Burden of Disease Study 2016 – JAMA Oncology (free)

“Global incident cases of multiple myeloma more than doubled from 1990-2016 w/incident cases increasing by 126%. The largest increase was in middle-SDI countries, particularly E. Asia with a 262% increase in incidence cases”. (via @IHME_UW see Tweet)

 

10 – Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women—A double-blind, randomized non-inferiority trial – PLOS Medicine (free)

Commentary: Ibuprofen alone not an option for simple UTIs, study finds – CIDRAP (free) AND Randomized trial finds ibuprofen not a safe alternative to antibiotics for UTIs – PLOS, via ScienceDaily (free)

Related Research: Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)

 


 

1 – News Release: First-ever WHO list of essential diagnostic tests to improve diagnosis and treatment outcomes (free) (via @Onisillos)

Executive summary: List of Essential In Vitro Diagnostics, First edition (2018) – World Health Organization (free PDF)

 

2 – Report: The Characteristics of Pandemic Pathogens: Improving Pandemic Preparedness by Identifying the Attributes of Microorganisms Most Likely to Cause a Global Catastrophic Biological Event – Johns Hopkins Bloomberg School of Public Health (free PDF)

News release: Study by center for health security identifies characteristics of microorganisms most likely to cause a global pandemic (free)

Commentaries: Is this the face of Disease X? The deadly pathogens which could cause the next global pandemic – The Telegraph (free) AND The Next Deadly Pandemic Could Be Unlike Any Threats We Know, Say Experts – Science Alert (free) AND The Next Pandemic: Forget Zika Or Ebola, Airborne Viruses Like The Flu And The Common Cold Are The Real Threat – Inquisitr (free) AND Report: Next Pandemic Will Likely Be Respiratory-Based Virus – MedPage Today (free registration required)

Related: Are we prepared for the looming epidemic threat? (free commentaries and video)

 

3 – Position Paper: Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories – Obesity Reviews (free)

Commentary: Some calories more harmful than others – University of California, via EurekAlert (free)

 

4 – Review: Diagnostic workup, etiologies and management of acute right ventricle failure – Intensive Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

 

5 – Improving Prediction of Dementia in Primary Care – Annals of Family Medicine (free)

Commentaries: Screening Tool Improves Dementia Prediction – Medscape (free registration required) AND Visual Test Could Help Predict Dementia Risk in Elders – NEJM Physician’s First Watch (free)

 

6 – Use of Flutemetamol F 18–Labeled Positron Emission Tomography and Other Biomarkers to Assess Risk of Clinical Progression in Patients With Amnestic Mild Cognitive Impairment – JAMA Neurology (free)

Commentaries: Biomarkers, PET imaging may predict cognitive decline en route to Alzheimer’s – Health Imaging (free) AND Amyloid PET Scan Can Predict Progression to Alzheimer’s in Patients With Mild Cognitive Impairment – MedicalResearch.com (free)

Related Studies: Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons (link to abstract and free commentaries) AND Identifying incipient dementia individuals using machine learning and amyloid imaging (free full-text and commentaries) AND High performance plasma amyloid-β biomarkers for Alzheimer’s disease (link to abstract and free commentaries)

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: April 2018 – eCancer News (free)

 

8 – Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non–Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Intravesical Gemcitabine Therapy Cuts Bladder Cancer Recurrence – MPR (free) AND Simple post-surgery step reduces bladder cancer recurrence – SWOG, via EurekAlert (free)

 

9 – Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Outcomes similar with DES vs. BMS in saphenous vein graft lesions – Healio (free registration required)

 

10 – Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence – JAMA (free for a limited period)

Related Reviews: Optimizing post‐polypectomy surveillance: A practical guide for the endoscopist – Digestive Endoscopy (free) AND Optimal Colonoscopy Surveillance Interval after Polypectomy – Clinical Endoscopy (free)

Related Guidelines: Guidelines for Colonoscopy Surveillance After Screening and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer (free) AND Korean Guidelines for Postpolypectomy Colonoscopy Surveillance – Digestive Endoscopy (free) AND Colorectal cancer surveillance after index colonoscopy: Guidance from the Canadian Association of Gastroenterology (free) AND Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline (free)

Advanced adenomas are associated with subsequent increased risk for colorectal cancer, but nonadvanced adenomas don’t seem to be associated with increased risk.

 


 

1 – News Release: WHO plan to eliminate industrially-produced trans-fatty acids from global food supply – World Health Organization (free)

See also: REPLACE Action package: Trans Fat Free by 2023 – World Health Organization (free resources)

Commentaries: Editorial Board Opinion: The World Doesn’t Need Trans Fats – The New York Times (10 articles per month are free) AND WHO calls for trans fats to be eliminated within five years – Reuters (free) AND Industrial trans fats must be removed from food supply, WHO says – The Guardian (free) AND The new global plan to eliminate the most harmful fat in food, explained – VOX (free)

 

2 – Experimental vaccine to be used against Ebola outbreak in the DRC – STAT (free)

Related: WHO to send vaccines to fight new Ebola outbreak – NBC News (free) AND The New Ebola Outbreak Could Take ‘Three, Maybe Four’ Months to Control – The Atlantic (free)

See also: WHO News: Ebola Outbreak Declared in Democratic Republic of the Congo (free news release and commentaries)

 

3 – Complete Revascularization During Primary Percutaneous Coronary Intervention Reduces Death and Myocardial Infarction in Patients With Multivessel Disease: Meta-Analysis and Meta-Regression of Randomized Trials – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

Commentary: Complete Revascularization During PCI for Multivessel STEMI – American College of Cardiology (free)

Related: Meta-Analysis of Culprit-Only vs Multivessel PCI in Patients with STEMI and Multivessel Coronary Disease (link to abstract, commentaries and Cochrane Review on the subject)

 

4 – The Burnout Crisis in American Medicine – The Atlantic (free)

Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free) AND To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians – New England Journal of Medicine (free)

 

5 – Richard Lehman’s journal review, 14 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

6 – Perspective: Deployment of Preventive Interventions — Time for a Paradigm Shift – New England Journal of Medicine (free)

 

7 – Headline vs. study: Sometimes fishy, sometimes pulling a rabbit out of a hat – Health News Review (free)

 

8 – Guideline: Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free) (via @Deprescribing)

Related: CaDeN Deprescribing Guidelines and Algorithms (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)

 

9 – NAP6 Report: Anaesthesia, Surgery and Life-Threatening Allergic Reactions: Report and findings of the Royal College of Anaesthetists’ 6th National Audit Project (free PDF)

News Release: RCoA undertakes largest ever study of anaphylaxis in anaesthesia and surgery (free)

Infographic: Anaesthesia, Surgery and Life-Threatening Allergic Reactions (free PDF)

“The study found teicoplanin is 17-fold more likely to cause anaphylaxis than penicillin and similar drugs. As 90 per cent of patients who report penicillin allergy are in fact not allergic, better identification of true allergy would reduce risk”. (from News Release)

 

10 – Guideline: Screening for impaired vision in community-dwelling adults aged 65 years and older in primary care settings – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers (free)

Commentaries: Screening for impaired vision in older adults: New Canadian guideline – Canadian Medical Association Journal, via EurekAlert (free) AND Canadian Guideline Recommends Against Vision Screening of Older Adults in Primary Care Settings – NEJM Physician’s First Watch (free)

 


 

1 – Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery – New England Journal of Medicine (free)

Editorial: Finding the Right Balance (free)

Commentaries: Restrictive fluids tied to kidney injury after major abdominal surgery – MDedge (free) AND Restricting Fluids During Abdominal Surgery Shows No Benefit, Possible Renal Risk – Medscape (free registration required)

 

2 – Investigational Testing for Zika Virus among U.S. Blood Donors – New England Journal of Medicine (free)

Quick Take Video Summary: Testing Blood Donations for Zika Virus (free)

Sounding Board: Revisiting Blood Safety Practices Given Emerging Data about Zika Virus (free)

Commentaries: Study: Zika blood donation screening costly, finds few cases – CIDRAP (free) AND Testing for Zika virus in blood donors finds few infections — at a cost of about $5.3 million each – STAT (free)

 

3 – Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo—a Meta-analysis of Individual Data – Gastroenterology (link to abstract – $ for full-text)

Commentary: Severe alcoholic hepatitis: corticosteroids alone are best for short-term survival – Univadis (free registration required)

 

4 – Advice for Patients: Are blood pressure measurement mistakes making you chronically ill? – American Heart Association News (free text and infographic)

Commentary: BP measurement: you’re probably doing it wrong – Univadis (free registration required)

 

5 – Oral Antibiotic Exposure and Kidney Stone Disease – Journal of the American Society of Nephrology (link to abstract – $ for full-text)

Commentaries: Study suggests oral antibiotics may increase kidney stone risk – CIDRAP (free) AND Antibiotics May Raise the Risk for Kidney Stones – The New York Times (free) AND Oral Antibiotics May Raise Risk of Kidney Stones – Children’s Hospital of Philadelphia, via NewsWise (free)

 

6 – Viewpoint: Management Reasoning: Beyond the Diagnosis – JAMA (free for a limited Period)

 

7 – Association of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Resistance Exercise Might Improve Depression Symptoms – NEJM Physician’s First Watch (free) AND Resistance exercise may reduce depressive symptoms in adults – MedicalXpress (free) AND Resistance Exercise Training May Alleviate Some Depressive Symptoms – MedicalResearch.com (free)

 

8 – Global statistics on alcohol, tobacco and illicit drug use: 2017 status report – Addiction (free PDF)

Commentaries: Alcohol and tobacco are by far the biggest threat to human welfare of all addictive drugs – Society for the Study of Addiction, via ScienceDaily (free) AND Which drugs pose the biggest threat to public health? – Medical News Today (free)

 

9 – Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of adverse events in non-randomised studies – Cochrane Library (link to abstract – $ for full-text)

Summary: Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of harmful effects – Cochrane Library (free)

“Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate”.

 

10 – Cost-effectiveness of Electroconvulsive Therapy vs Pharmacotherapy/Psychotherapy for Treatment-Resistant Depression in the United States – JAMA Psychiatry (free for a limited period)

Author interview: Cost-effectiveness of Electroconvulsive Therapy for Treatment-Resistant Depression in the United States (free)

Commentaries: Study about ‘shock therapy’ for depression suggests more patients should try it sooner – Michigan Medicine – University of Michigan, via EurekAlert (free) AND Third-Line Electroconvulsive Therapy May Be Best for Patients With Treatment-Resistant Depression – Psychiatric News Alert (free) AND ECT Found Cost Effective Early in Depression Treatment – MedPage Today (free registration required)

 


 

1 – AHA/ACOG Presidential Advisory: Promoting Risk Identification and Reduction of Cardiovascular Disease in Women Through Collaboration with Obstetricians and Gynecologists – Circulation (free PDF)

News Releases: OB-GYNs, cardiologists join to fight the No. 1 killer of women (free) AND Annual well woman visit to the OB/GYN can keep your heart healthy: AHA/ACOG Presidential Advisory (free)

Top Ten Things to Know: Promoting Risk Identification and Reduction of Cardiovascular Disease in Women Through Collaboration with Obstetricians and Gynecologists (free PDF)

 

2 – Vertebroplasty versus sham procedure for painful acute osteoporotic vertebral compression fractures (VERTOS IV): randomised sham controlled clinical trial – The BMJ (free)

Editorial: No more vertebroplasty for acute vertebral compression fractures? (free)

Related Systematic Review: Percutaneous vertebroplasty for osteoporotic vertebral compression fracture – Cochrane Library (link to abstract and summary)

 

3 – CABANA: No Outcomes Benefit In First Big Trial Of AF Ablation – Cardiobrief (free)

Related Commentaries: Catheter ABlation vs ANtiarrhythmic Drug Therapy in Atrial Fibrillation – CABANA – American College of Cardiology (free) AND CABANA Misses Primary Endpoint, but Electrophysiologists See Support for Ablation – TCTMD (free)

 

4 – Guideline: Erectile Dysfunction – American Urology Association (2018) (free)

 

5 – EULAR recommendations for the health professional’s approach to pain management in inflammatory arthritis and osteoarthritis – Annals of Rheumatic Diseases (free)

Commentary: EULAR Releases Recommendations for Pain Management in OA, Inflammatory Arthritis – Rheumatology Advisor (free)

 

6 – Perspective: The Catch-22 of Mass-Prescribing Antibiotics – Wired (free)

Related Commentary: African study on pre-emptive antibiotics in kids spurs resistance debate – CIDRAP (free)

Related Study: Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa – New England Journal of Medicine (free)

 

7 – Mode of delivery after a previous cesarean birth, and associated maternal and neonatal morbidity – Canadian Medical Association Journal (free)

Commentary: Higher risks associated with vaginal birth after cesarean, although absolute risk small – CMAJ, via ScienceDaily (free)

 

8 – New Online Course: An introduction to systematic searching in PubMed – University of Nottingham (free)

“This course shows you how you can construct a comprehensive, systematic search strategy in PubMed to answer a clinical question” (via @CochraneUK see Tweet)

 

9 – Systematic Review: Induction of labour for improving birth outcomes for women at or beyond term – Cochrane Library (free)

Summary: Induction of labour in women with normal pregnancies at or beyond term – Cochrane Library (free)

 

10 – Risk of stroke and transient ischaemic attack in patients with a diagnosis of resolved atrial fibrillation: retrospective cohort studies – The BMJ (free)

Commentaries: Tom Marshall: The importance of asking the right research question – BMJ Opinion (free) AND Patients who have had an irregular heart beat can’t ever be considered ‘cured’ – University of Birmingham (free)

 


 

1 – Accelerate progress—sexual and reproductive health and rights for all: report of the Guttmacher–Lancet Commission – The Lancet (free)

News Release: Guttmacher-Lancet Commission Proposes a Bold, New Agenda for Sexual and Reproductive Health and Rights – Guttmacher Institute (free)

Executive Summary: Accelerate Progress: Sexual and Reproductive Health and Rights for All – Guttmacher Institute (free)

Invited commentaries: Sexual and reproductive health and rights for all: an urgent need to change the narrative (free) AND Addressing the unfinished agenda on sexual and reproductive health and rights in the SDG era (free) AND Defining sexual and reproductive health and rights for all (free)

Commentaries: Why it could cost less than R120 per year to save a life – Bhekisisa (free) AND Gender-based violence must be at the heart of global health agenda: expert comment – London School of Hygiene & Tropical Medicine (free)

 

2 – Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors – Cochrane Library (link to abstract and summary – $ for full-text)

News Release: Does HPV vaccination prevent the development of cervical cancer? Are there harms associated with being vaccinated? – Cochrane Library (free)

Scientific Expert Reaction: Cochrane Review on HPV vaccine for cervical cancer prevention in girls and women – Cochrane Library (free)

Commentaries: HPV vaccine ‘safe and effective’, says review – NHS Choices (free) AND Experts welcome new evidence on HPV jab efficacy and safety – OnMedica (free)

  

3 – High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial – Circulation (free)

With a median follow-up of 3.9 years, high-dose as compared with low-dose pitavastatin significantly reduced the risk of the primary end point (4.3% vs 5.4%; NNT = 90), a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, or unstable angina requiring emergency hospitalization.

 

4 – Implications for paediatric shock management in resource-limited settings: a perspective from the FEAST trial – Critical Care (free)

Original article: Mortality after Fluid Bolus in African Children with Severe Infection – New England Journal of Medicine (free)

 

5 – Call for public comments on the draft WHO Guidelines: Saturated fatty acid and trans-fatty intake for adults and children – World Health Organization (free)

Commentaries: Eat less saturated, trans fats to curb heart disease: WHO – Reuters (free) AND Eat Less Saturated and Trans Fats, World Health Organization Says – Consumer Reports (free) AND ‘Bad’ fats targeted in new global health guidelines – UN News (free)

“Adults and children should consume a maximum of 10 percent of their daily calories in the form of saturated fat such as meat and butter and one percent from trans fats to reduce the risk of heart disease, the World Health Organization said on Friday” (from Reuters)

 

6 – Effect of post-discharge virtual wards on improving outcomes in heart failure and non-heart failure populations: A systematic review and meta-analysis – PLOS One (free)

Commentary: Hospital-to-home transitional care reduces deaths, readmissions for heart failure – Cardiovascular Business (free)

 

7 – Correction to: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association – Stroke (free PDF)

Commentaries: AHA Rescinds Large Sections of New Stroke Guidelines – Medscape (free registration required) AND AHA/ASA retracts large portion of new stroke guidelines – Cardiovascular Business (free)

 

8 – Editorial: All science should inform policy and regulation – PLOS Medicine (free) (via @RasoiniR)

 

9 – Association of Preprocedural Fasting With Outcomes of Emergency Department Sedation in Children – JAMA Pediatrics (free for a limited period)

Commentaries: Preprocedural Fasting Not Necessary for Children in ED – Medscape (free registration required) AND Pre-Sedation Guidelines for Kids May Be Too Strict – MedPage Today (free registration required)

Related: NPO for sedation? Don’t swallow the myth – First10Em (free)

 

10 – Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Author Interview: Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults (free)

Commentaries: Psychological interventions can help treat chronic pain in seniors – UPI (free) AND Not All In Your Head: Psychological Therapies Not a Panacea for Pain – MedicalResearch.com (free)

 


 

1 – Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children – Canadian Journal of Cardiology (free)

 

2 – Hypertension Canada’s 2018 Guidelines for the Management of Hypertension in Pregnancy – Canadian Journal of Cardiology (free)

 

3 – Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Prostate-Specific Antigen (PSA) Screening for Prostate Cancer: Revisiting the Evidence (free) AND USPTF Prostate Cancer Screening Recommendations—A Step in the Right Direction (free) AND Implications of the New USPSTF Prostate Cancer Screening Recommendation—Attaining Equipoise (free) AND Prostate Cancer Screening—A New Recommendation for Meaningful Physician-Patient Conversations (free)

Author Interview: USPSTF Recommendation: Screening for Prostate Cancer (free)

Video Summary: PSA Screening for Prostate Cancer: The 2018 USPSTF Recommendation Statement (free)

Infographic with key Facts: Is Prostate Cancer Screening Right for You? Understanding the Potential Benefits vs. Harms for Men 55-69 (free)

Commentary: Prostate cancer screening: the decision is up to you – Reuters (free)

 

4 – Effect of Coaching to Increase Water Intake on Kidney Function Decline in Adults With Chronic Kidney Disease: The CKD WIT Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: Drinking more water does not slow decline of kidney function for kidney disease patients – Lawson Health Research Institute, via EurekAlert (free) AND Study: Drinking more water doesn’t slow kidney disease – UPI (free)

 

5 – Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans – JAMA Neurology (free for a limited period)

Editorial: Risk of Dementia Outcomes Associated With Traumatic Brain Injury During Military Service (free)

Commentaries: Dementia Risk Doubles Following Concussion, UCSF Study Shows – University of California San Francisco (free) AND Vets with Head Injury More Likely To Develop Dementia – MedicalResearch.com (free)

See two recent cohort studies with similar results: Long-term risk of dementia among people with traumatic brain injury (link to abstract and free commentaries) AND Traumatic Brain Injury and the Risk of Dementia Diagnosis (free article and commentaries)

 

6 – New Ebola outbreak declared in Democratic Republic of the Congo – World Health Organization (free)

Commentaries: New Ebola outbreak confirmed in DR Congo: UN health agency scales up response – UN News (free) AND Seventeen deaths reported in Congo as Ebola outbreak confirmed – Reuters (free) AND DRC confirms 2 Ebola infections, probes suspected cases – CIDRAP (free)

 

7 – Guideline: Investigation and management of a raised serum ferritin – British Journal of Haematology (free)

 

8 – Richard Lehman’s journal review, 8 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Alzheimer’s? Your Paperwork May Not Be in Order – The New York Times (10 articles per month are free)

Related: New Document for Patients: Advanced Health Directive for Dementia (free document and commentaries)

 

10 – Platelet Count Affects Efficacy of Folic Acid in Preventing First Stroke – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Folic acid ‘may help reduce stroke risk in people with high blood pressure’ – NHS Choices (free) AND Folic Acid Supplements May Reduce Stroke Risk in Hypertensive Patients – American College of Cardiology (free) AND Folic Acid Cut Strokes in Hypertensive Patients on Enalapril – MedPage Today (free registration required) AND Folic acid supplementation may help prevent first stroke in high-risk patients with hypertension – ACP Internist (free)

 


 

1 – Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet – Pediatrics (free)

Commentaries: How Low Can You Go? Does Lower Carb Translate to Lower Glucose? – Pediatrics (free) AND Very-low-carb diet shows promise in type 1 diabetes – Boston Children’s Hospital, via ScienceDaily (free) AND How a Low-Carb Diet Might Aid People With Type 1 Diabetes – The New York Times (10 articles per month are free) AND Is Exceptional Control of Type 1 Diabetes Possible with a Low-Carbohydrate Diet? – Dr. David Ludwig Blog (free)

*Randomized controlled trials are warranted.

 

2 – Clinical Oncology Society of Australia position statement on exercise in cancer care – The Medical Journal of Australia (free)

Commentaries: Every cancer patient should be prescribed exercise medicine – The Conversation (free) AND Cancer: ‘If exercise was a pill it would be prescribed to every patient’ – The Guardian (free)

 

3 – Guideline: Management of stable angina – Scottish Intercollegiate Guidelines Network (free)

 

4 – Guideline: Pharmacological management of migraine – Scottish Intercollegiate Guidelines Network (free)

 

5 – The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)

Opinion Against this Guideline: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free) (via @emdocsdotnet)

 

6 – Review: Alternatives to the Swan–Ganz catheter – Intensive Care Medicine (free for a limited period) (via @f_g_zampieri)

 

7 – Perspective: Questionable Admissions – New England Journal of Medicine (free)

 

8 – Clinical Handbook: Care of girls and women living with female genital mutilation – World Health Organization (free)

 

9 – Summary: AHA Scientific Statement on Right Heart Failure – American College of Cardiology (free)

Original Guideline: Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association (free PDF)

 

10 – Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology – European Journal of Heat Failure (free)

 


 

1 – SAVE LIVES: Clean Your Hands, 5 May 2018 – World Health Organization Campaign (free guidelines, implementation tools, infographics, videos and more)

“It’s in your hands – prevent sepsis in health care”

 

2 – Consensus statement for cancer patients requiring intensive care support – Annals of Hematology (free)

Source: Critical Care Reviews Newsletter

 

3 – Comprehensive in‐hospital monitoring in acute heart failure: applications for clinical practice and future directions for research. A statement from the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) – European Journal of Heart Failure (free)

Source: Critical Care Reviews Newsletter

 

4 – A Simple Way to Improve a Billion Lives: Eyeglasses – The New York Times (10 articles per month are free)

“It’s the biggest health crisis you’ve never heard of. Doctors, philanthropists and companies are trying to solve it”.

 

5 – Opinion: Can we say who has died because of the breast-screening appointment error? – by David Spiegelhalter (free) (via @RichardLehman1 and @d_spiegel, see Tweet with infographic)

Related opinions: Breast cancer screening scandal must prompt review of mammograms – The Guardian (free) AND Breast cancer screening programme ‘does more harm than good’ – BBC (free) AND Did Breast Cancer Screening Error Cause Major Health Harm? – Medscape (free registration required)

 

6 – Decisions, Decisions: HMS physicians review the many factors in choosing breast cancer screenings – Harvard Medical School (free commentary and video) (via @tlisboa79 and @brhospitalist)

Original article: Breast Cancer Screening in 2018: Time for Shared Decision Making – JAMA (link to abstract – $ for full-text)

 

7 – Don’t confuse “no evidence of a difference” with “evidence of no difference” – Students 4 Best Evidence (free)

 

8 – University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free)

Related: Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

 

9 – Pre-pregnancy fast food and fruit intake is associated with time to pregnancy – Human Reproduction (free)

Commentary: Women who eat fast food may take longer to get pregnant – NHS Choices (free) AND Women Who Eat Fast Food Take Longer to Become Pregnant – University of Adelaide, via NewsWise (free) AND Want to increase fertility? Try dropping fast food – CNN (free)

 

10 – Sauna bathing reduces the risk of stroke in Finnish men and women: A prospective cohort study – Neurology (link to abstract – $ for full-text)

Commentaries: Daily saunas may reduce stroke risk – NHS Choices (free) AND Can Saunas Lower Stroke Risk? – MedPage Today (free registration required) AND Could saunas reduce stroke risk? – Medical News Today (free)

 


 

1 – Manual: Core Components for Infection Prevention and Control: Implementation tools and resources – World Health Organization (free) (via @julesstorr and @Onisillos)

 

2 – Outpatient Infection Prevention: A Practical Primer – Open Forum Infectious Diseases (free) (via @IDSAInfo see Tweet)

Commentary: Pioneering Paper Shows Infection Control and Prevention in Clinics Is in Everyone’s Hands – University of Texas Health Science Center at Houston, via NewsWise (free)

 

3 – Emollient bath additives for the treatment of childhood eczema (BATHE): multicentre pragmatic parallel group randomised controlled trial of clinical and cost effectiveness – The BMJ (free)

Editorial: New evidence challenges use of bath emollients for children with eczema (free)

Commentaries: Trial finds no benefit of bath emollients beyond standard eczema care for children – The BMJ, via ScienceDaily (free) AND Bath oils for childhood eczema provide ‘no clinical benefit’ – NHS Choices (free)

 

4 – Education plus exercise versus corticosteroid injection use versus a wait and see approach on global outcome and pain from gluteal tendinopathy: prospective, single blinded, randomised clinical trial – The BMJ (free)

Commentary: The ongoing reduction in pain became the inspiration to never go back to “ground zero” – The BMJ Opinion (free)

 

5 – Plastic Surgery’s Contributions to Surgical Ethics – AMA Journal of Ethics (free)

“Important for plastic surgeons in particular to remember: just because you *can* perform an operation, which might or might not be medically indicated, does not mean you *should* perform the operation” (via @JournalofEthics see Tweet)

 

6 – Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Single-Inhaler Triple Therapy in Patients with COPD (free)

 

7 – Lecture: How Less Health Care Can (Sometimes) Be Better For You (free)

See also: CLUE Working Group Lecture Series (tweet with lecture links by @KariTikkinen)

“Editor-in-Chief of @JAMAInternalMed, professor Rita Redberg gave the 3rd CLUE Working Group lecture entitled “How Less Health Care Can (Sometimes) Be Better For You” at the Think Corner of the U of Helsinki” (via @KariTikkinen see Tweet)

 

8 – 2017 European guideline for the screening, prevention and initial management of hepatitis B and C infections in sexual health settings – International Journal of STD & AIDS (free PDF)

 

9 – Direct oral anticoagulant (DOAC) versus low-molecular-weight heparin (LMWH) for treatment of cancer associated thrombosis (CAT): A systematic review and meta-analysis – Thrombosis Research (free)

Source: EvidenceAlerts

 

10 – Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression – JAMA Psychiatry (free for a limited period)

Commentaries: With Early Intervention, Patients With Schizophrenia Experience Greater Improvements in Health, Function – Psychiatric News Alert (free) AND Early Intervention Best for Early-Phase Psychosis – MedPage Today (free registration required)

 


 

1 – Pre-operative evaluation of adults undergoing elective noncardiac surgery: Updated guideline from the European Society of Anaesthesiology (free)

 

2 – Support for midlife anxiety diagnosis as an independent risk factor for dementia: a systematic review – BMJ Open (free)

Commentaries: Moderate to severe mid-life anxiety may be linked to later life dementia – BMJ Open Blog (free) AND Anxiety in middle age linked to dementia later – Reuters (free) AND Expert reaction to a review of the association between mid-life anxiety and later life dementia – Science Media Centre (free)

“The current study isn’t designed to explain how anxiety and dementia might be connected, Iadecola added. “We cannot say with confidence that anxiety is a cause (risk factor), an early manifestation of the dementia, or only coincidentally associated with it,”” (from Reuters)

 

3 – Report: Trends in Reported Vectorborne Disease Cases — United States and Territories, 2004–2016 – MMWR, CDC (free)

Commentaries: CDC reports tripling of vector-borne diseases since 2004 – CIDRAP (free) And Tick and Mosquito Infections Spreading Rapidly, C.D.C. Finds – The New York Times (10 articles per month are free) AND Tick- and mosquito-borne diseases more than triple, since 2004, in the US – CNN (free)

 

4 – Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Three-Minute Brain Stimulation Sessions Effectively Reduce Depression Symptoms, Study Finds – Forbes (free) AND Three Minute Version of Brain Stimulation Therapy Effective for Hard to Treat Depression – Neuroscience News (free)

 

5 – Nonpharmacologic and Medication Minimization Strategies for the Prevention and Treatment of ICU Delirium: A Narrative Review – Journal of Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

 

6 – Systematic Reviews & Meta-Analyses: A 5-Step Checkup – Absolutely Maybe in PLOS Blogs (free)

 

7 – Prospective study on the incidence, prevalence and 5-year pancreatic-related mortality of pancreatic cysts in a population-based study – Gut (free)

Commentary: Incidental Pancreatic Cysts: Majority Don’t Progress to Cancer – Medscape (free registration required)

 

8 – Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease: A Scientific Statement From the American Heart Association – Circulation (free PDF)

News release: New guidance issued for treating cardiac arrest in children with heart disease (free)

Top Ten Things to Know: Cardiopulmonary Resuscitation in Infants and Children with Cardiac Disease (free PDF)

 

9 – Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Commentary: ASCO Clinical Practice Guideline Update: Fertility Preservation in Patients With Cancer – The ASCO Post (free)

Related guidelines: Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines – Clinical and Experimental Reproductive Medicine (free) AND Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline – Human Fertility (free)

 

10 – USPSTF Draft Recommendation Statement: Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: Screening (free)

Commentaries: USPSTF urges abuse screening for reproductive-aged women – MedicalXpress (free) AND USPSTF Recommends Screening for Partner Violence in Reproductive-Aged Women – Clinical Advisor (free)

“The USPSTF recommends that clinicians screen for intimate partner violence (IPV) in women of reproductive age and provide or refer women who screen positive to ongoing support services.”

 


 

1 – 9 out of 10 people worldwide breathe polluted air, but more countries are taking action – World Health Organization (free)

Related Infographics: PHE Infographics: Air pollution (free)

Updated Fact Sheets: Ambient (outdoor) air quality and health (free) AND Household air pollution and health (free)

Commentaries: Air pollution inequality widens between rich and poor nations – The Guardian (free) AND Expert reaction to new WHO global air pollution data – Science Media Centre (free)

 

2 – 2018 ACC/HRS/NASCI/SCAI/SCCT Expert Consensus Document on Optimal Use of Ionizing Radiation in Cardiovascular Imaging: Best Practices for Safety and Effectiveness (Free)

Commentary: New Expert Consensus Document Provides Best Practices For Ionizing Radiation Safety – American College of Cardiology (free)

 

3 – Long-Term Effects of Omitting Antibiotics in Uncomplicated Acute Diverticulitis – American Journal of Gastroenterology (link to abstract – $ for full-text)

Commentary: Uncomplicated acute diverticulitis: omitting antibiotics found safe in DIABOLO – Univadis (free registration required)

 

4 – Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: Glyburide Should Not Be First-Line for Gestational Diabetes – Medscape (free registration required) AND Glyburide Compared With Insulin for First-Line Tx of Gestational Diabetes – MPR (free)

 

5 – Clinical Practice Guideline: Chronic Asthma – Toward Optimized Practice (free PDF)

See also: Summary (free PDF)

Related: see all TOP Clinical Practice Guidelines, a practical resource for Family Physicians at the point of care.

 

6 – Viewpoint: In the Era of Precision Medicine and Big Data, Who Is Normal? – JAMA (free for a limited period)

 

7 – Dietary intake and age at natural menopause: results from the UK Women’s Cohort Study – Journal of Epidemiology & Community Health (free)

Commentaries: Diet rich in fish and legumes may help to delay natural menopause – BMJ, via EurekAlert (free) AND Expert reaction to study looking at dietary intake and age at menopause – Science Media Centre (free) AND Oily fish and fresh beans may be linked to a later menopause – NHS Choices (free)

 

8 – Interventions for preventing occupational irritant hand dermatitis – Cochrane Library (link to abstract – $ for full-text)

Summary: Treatments to prevent hand skin irritation in the workplace – Cochrane Library (free)

 

9 – Indications for the Performance of Intracranial Endovascular Neurointerventional Procedures: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Key Points to Remember: Indications for Intracranial Endovascular Procedures – American College of Cardiology (free)

 

10 – Preventability of Early Versus Late Hospital Readmissions in a National Cohort of General Medicine Patients – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Hospital care quality more likely a factor in early versus late readmissions – ACP Hospitalist (free) AND Hospital readmissions occurring within 7 days post-discharge may be more preventable than later readmissions – 2 Minute Medicine (free)

 


 

1 – Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentary: Too liberal use of oxygen increases risk of death in acutely ill adult patients – McMaster University, via EurekAlert (free)

 

2 – Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital records: an observational study – The Lancet (free)

Commentaries: What proportion of older adults in hospital are frail? – The Lancet (free) AND Research helps frail older people in hospitals – University of Leicester, via EurekAlert (free)

 

3 – Universal health care, worldwide, is within reach – The Economist (a few articles per month are free)

Source: International Health Policies Newsletter

 

4 – Guide to Improving Patient Safety in Primary Care Settings by Engaging Patients and Families – Agency for Healthcare Research and Quality (free PDF)

See also: About the Guide (free) AND Infographic (free PDF) AND Quick Start Guide (free)

 

5 – Expert statement for the management of hypovolemia in sepsis – Intensive Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

 

6 – Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018 – Gut (free)

Source: Critical Care Reviews Newsletter

 

7 – Improving Emergency Department Care for Low-Risk Chest Pain – NEJM Catalyst (free)

 

8 – Debate: Should we recommend e-cigarettes to help smokers quit? – The BMJ (free)

See also: related guidelines, reports and commentaries on e-cigarettes

“Experts debate: Should doctors recommend e-cigarettes to help smokers quit? Revelation in harm reduction or a way to keep people addicted and gateway to youth smoking?” (via @rich_hurley see Tweet)

 

9 – 28th ECCMID: The MERINO Trial: piperacillin-tazobactam versus meropenem for the definitive treatment of bloodstream infections caused by third-generation cephalosporin nonsusceptible Escherichia coli or Klebsiella spp.: an international multi-centre openlabel non-inferiority randomised controlled trial (free abstract)

Commentaries: Avoid piperacillin-tazobactam when treating BSI cause by ceftriaxone-resistant pathogens – European Society of Clinical Microbiology and Infectious Diseases, via EurekAlert (free) AND Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free)

 

10 – Predictors of post-stroke fever and infections: a systematic review and meta-analysis – BMC Neurology (free)

Commentary: Predictors of poststroke pneumonia clarified – Univadis (free)

 


 

1 – Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population – Circulation (free PDF)

Commentaries: Five healthy habits may add more than a decade to life – Circulation Journal Report (free) AND The five habits that can add more than a decade to your life – The Guardian (free) AND Following five healthy lifestyle habits may increase life expectancy by decade or more – Harvard T.H. Chan School of Public Health, via ScienceDaily (free)

 

2 – Meta-Analysis: Radial-Artery or Saphenous-Vein Grafts in Coronary-Artery Bypass Surgery – New England Journal of Medicine (free for a limited period)

Commentaries: More Data Show Benefits of Multiple Arterial Over Saphenous-Vein Grafting in CABG: Meta-analysis – TCTMD (free) AND Radial Artery or Saphenous Vein Grafts in CABG – American College of Cardiology (free)

 

3 – Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Stroke: Which Clot Buster Drug Works Best? – MedicalResearch.com (free) AND Tenecteplase Appears Superior to Alteplase After Ischemic Stroke – Cardiology Advisor (free)

 

4 – Report: Using Technology to Advance Global Health – National Academies of Sciences, Engineering, and Medicine. 2018 (free PDF, registration required)

 

5 – Are sweet snacks more sensitive to price increases than sugar-sweetened beverages: analysis of British food purchase data – BMJ Open (free)

Commentaries: Taxing sweet snacks may bring even greater health benefits than taxing sugar-sweetened drinks – London School of Hygiene & Tropical Medicine (free) AND Soda Tax Backers Eye Cookies and Candy – MedPage Today (free)

Related: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND To improve global health, tax the things that are killing us (free articles, commentaries and reports) AND The Lancet taskforce on NCDs and economics (free series and commentaries)

 “A 10% tax would reduce the purchase of chocolates and other candy by 7.4%, of cookies by 6.9%, and of cake-type snacks by 6.6%” (via @medpagetoday see Tweet)

 

6 – Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Regular exercise may help lower your risk of depression – NHS Choices (free) AND Regular Exercise Lowers Odds of Developing Depression, Meta-Analysis Finds – Psychiatric News Alert (free)

 

7 – Report: Using dietary intake modelling to achieve population salt reduction – A guide to developing a country-specific salt reduction model (2018) – WHO Europe (free PDF)

“The Salt Reduction Model is a 5-step plan to help countries achieve a 30% reduction in population salt intake. Reducing salt consumption will help prevent and control noncommunicable diseases such as heart disease and stroke” (via @WHO_Europe see Tweet)

 

8 – Richard Lehman’s journal review, 30 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Economics of Palliative Care for Hospitalized Adults With Serious Illness: A Meta-analysis – JAMA Internal Medicine (free for a limited period)

Commentaries: Study: Palliative Care Reduces Hospital Stay, Cost of Sickest Patients – U.S. News (free) AND Prompt Palliative Care Saves Money, Especially in Sickest Patients – MedPage Today (free registration required)

 

10 – Exploring the Role of Infographics for Summarizing Medical Literature – Health Professions Education (free)

“Are #infographic / #visualabstract summaries of literature preferred to abstracts? Do they decrease cognitive load? Do they increase retention? Check out our latest!” (via @Brent_Thoma see Tweet and Visual Abstract)

 


 

1 – Microbial Preparations (Probiotics) for the Prevention of Clostridium difficile: Infection in Adults and Children: An Individual Patient Data Meta-analysis of 6,851 Participants – Infection Control & Hospital Epidemiology (free)

Commentary: Probiotics may be safe, low-cost prevention tool for Clostridium difficile infections – News Medical (free)

Related Articles: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use – Cochrane Library (free) AND Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free) AND Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)

 

2 – Anticholinergic drugs and risk of dementia: case-control study – The BMJ (free)

Editorial: Anticholinergic drugs and dementia in older adults (free)

Commentaries: Expert reaction to study investigating the association between different types of anticholinergic drugs and risk of dementia – Science Media Centre (free) AND Anticholinergic drugs may be linked to increased risk of dementia – OnMedica (free)

“The effect of anticholinergic therapy is relatively small (odds ratio 1.1 – 1.2) and establishing an association does not prove a causal link. Nevertheless, the paper may act as a useful guide for future research and clinical practice”. (by Prof Les Iversen, in Science Media Centre)

 

3 – Age and sex of surgeons and mortality of older surgical patients: observational study – The BMJ (free)

Editorial: Links between age and sex of surgeons and patients’ outcomes (free)

Commentary: Study Suggests Older Surgeons Produce Lower Mortality Rates in Emergency Procedures – UCLA, via NewsWise (free)

 

4 – Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis – Cochrane Library (free for a limited period)

News Release: Featured Review: Uterotonic agents for preventing postpartum haemorrhage – Cochrane Library (free)

Commentary: Review finds more effective drugs to stop bleeding after childbirth – University of Birmingham (free)

New Cochrane Review suggests ergometrine plus oxytocin; misoprostol plus oxytocin; & carbetocin on its own, are more effective drugs for reducing excessive bleeding at childbirth rather than the current standard use of oxytocin on its own” (via @CochraneUK see Tweet)

 

5 – Optimised care of elderly patients with acute coronary syndrome – European Heart Journal: Acute Cardiovascular Care (free) (via @krychtiukmd see Tweet)

 

6 – Perspective: The Mediterranean Diet’s Fight Against Frailty – JAMA (free for a limited period)

 

7 – Committee Opinion: Adolescents and Long-Acting Reversible Contraception: Implants and Intrauterine Devices – American College of Obstetrics and Gynecology (free)

Commentary: ACOG Committee Opinion: adolescents should be offered LARC – Univadis (free registration required)

 

8 – Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines. Update April 2018 – Journal of Virus Eradication (free)

Related guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)

 

9 – Being patient with EBM. “Just because we can, doesn’t mean we should” – supporting informed decision-making – Evidently Cochrane Blog (free)

 

10 – NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure – Circulation (link to abstract – $ for full-text)

Related Systematic Review: Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model – Health Technology Assessment (free) AND Commentary: Uncertain benefits of BNP blood tests to monitor heart failure treatment – NIHR Signal (free)

Related AHA Scientific Statement: Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure (free)

Source:  EvidenceAlerts

“NT Pro BNP guided heart failure treatment no better than usual care”. (via @doctorvec)

 


 

1 – World Malaria Day, 25 April 2018 – World Health Organization (free resources)

 

2 – Effect of generalised access to early diagnosis and treatment and targeted mass drug administration on Plasmodium falciparum malaria in Eastern Myanmar: an observational study of a regional elimination programme – The Lancet (free)

Commentaries: Can improving access to care help to eliminate malaria? – The Lancet (free) AND Dose entire population with anti-malaria drugs to eradicate disease – study – The Guardian (free) AND Malaria studies show benefit of mass treatment, methylene blue – CIDRAP (free)

Related: Seminar: Malaria (free registration required) AND Series: Malaria in Pregnancy (free registration required)

 

3 – Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa – New England Journal of Medicine (free)

Quick Take Video Summary: Azithromycin to Reduce Childhood Mortality (free)

Commentaries: Giving Antibiotics To Healthy Kids In Poor Countries: Good Idea Or Bad Idea? – NPR (free) AND Infant Deaths Fall Sharply in Africa With Routine Antibiotics – The New York Times (free)

 

4 – Guideline: Pharmacologic Glycemic Management of Type 2 Diabetes in Adults – Canadian Journal of Diabetes (free)

Related Guidelines: ADA 2018 Standards of Medical Care in Diabetes (free) AND ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes (free)

In this new guideline Hemoglobin A1c Targets are similar from ADA 2018 Standards.

 

5 – Polypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) (via @trishgreenhalgh)

Related Reviews: Current and future perspectives on the management of polypharmacy – BMC Family Medicine (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free)

 

6 – Incorporating medication indications into the prescribing process – American Journal of Health-System Pharmacy (free)

Source: Hospital Medicine Virtual Journal Club (free)

 

7 – Guideline Update: Depression in adults: recognition and management – National Institute for Health and Care Excellence (free)

 

8 – Things We Do For No Reason: Periprocedural Bridging Anticoagulation – Journal of Hospital Medicine (free)

 

9 – A cancer drug tailored to your tumor? Experts trade barbs over ‘precision oncology’ – Science (free)

See also: Audio and slides on the meeting webcast (free) (via @barttels2 and @AACRPres see Tweet)

 

10 – Physicians’ Compassion, Communication Skills, and Professionalism With and Without Physicians’ Use of an Examination Room Computer: A Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)

Commentaries: Patients Prefer Doctors Who Engage in Face-to-Face Visits – Physician’s Briefing (free) AND Docs Behind Screen Seen as Less Compassionate – MedPage Today (free registration required) AND Patients value eye contact from physicians: study – Univadis (free registration required)

 


 

1 – A Randomized Trial of Early Endovenous Ablation in Venous Ulceration – New England Journal of Medicine (free)

Commentary: Early treatment for leg ulcers gets patients back on their feet – Imperial College London (free)

 

2 – Committee Opinion: Optimizing Postpartum Care – American College of Obstetricians and Gynecologists (free)

Commentary: Redesigning Maternal Care: OB-GYNs Are Urged to See New Mothers Sooner and More Often – ProPublica (free)

Source: Kaiser Health News Morning Brief

 

3 – Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Sigmoidoscopy reduces colon cancer risk for men, but not women – American College of Physicians, via MedicalXpress (free) AND Sigmoidoscopy reduces colon cancer risk for men, but not women – 2 Minute Medicine (free)

 

4 – Heading Frequency Is More Strongly Related to Cognitive Performance Than Unintentional Head Impacts in Amateur Soccer Players – Frontiers in Neurology (free)

Commentary: Soccer Heading—Not Collisions—Cognitively Impairs Players – Albert Einstein College of Medicine (free)

Related Review: Effects of Soccer Heading on Brain Structure and Function – Frontiers in Neurology (free)

 

5 – Teaching Computers to “See” the Invisible in Living Cells – NIH Director’s Blog (free)

Original Study: In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images (free) AND Commentary: Scientists teach computers how to analyze brain cells – NIH News Release (free)

 

6 – Pasta Is Good For You, Say Scientists Funded By Big Pasta – BuzzFeed News (free)

 

7 – Domain Management Approach to Heart Failure in the Geriatric Patient: Present and Future – Journal of the American College of Cardiology (free for a limited period) (via @monicaAGrinberg)

 

8 – Viewpoint: David Oliver: Tube feeding and deteriorating patients—guidelines can take us only so far – The BMJ (free)

Related Guidelines: American Geriatrics Society Feeding Tubes in Advanced Dementia Position Statement (free) AND ESPEN guideline on ethical aspects of artificial nutrition and hydration (free)

Related Reviews: Artificial nutrition and hydration in advanced dementia – Canadian Family Physician (free) AND End-of-life issues in advanced dementia: Part 1: goals of care, decision-making process, and family education – Canadian Family Physician (free) AND End-of-life issues in advanced dementia: Part 2: management of poor nutritional intake, dehydration, and pneumonia – Canadian Family Physician (free) AND Advanced Dementia – New England Journal of Medicine (free)

 

9 – Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies – American Journal of Epidemiology (free)

Commentary: Prolonged acetaminophen use during pregnancy linked to increased ASD and ADHD risk – The Hebrew University of Jerusalem, via EurekAlert (free)

 

10 – Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study – BMJ Open (free)

Commentaries: Fetal exposure to moderate/high caffeine levels linked to excess childhood weight gain – BMJ Open Blog (free) AND Caffeine in pregnancy linked to risk of child overweight – OnMedica (free) AND Expert reaction to study looking at caffeine in pregnancy and weight gain in children – Science Media Centre (free)

 


 

1 – World Immunization Week, 24-30 April 2018 – World Health Organization (free resources)

 

2 – The vaccine dilemma: how experts weigh benefits for many against risks for a few – STAT (free)

 

3 – Why do we need vaccines? – Welcome Trust (free) (via @greg_folkers)

 

4 – Exercise after a heart attack — it could save your life, research suggests – European Society of Cardiology, via ScienceDaily (free)

Other commentaries: Regular exercise after heart attack might halve risk of death over next few years – OnMedica (free) AND It’s not too late: Exercise after heart attack cuts mortality risk – Cardiovascular Business (free) AND Remaining Active After MI May Help Stave Off Mortality – TCTMD (free)

“Becoming more physically active after a myocardial infarction halves the risk of dying within 4 years, study finds”

 

5 – Safety and efficacy of dual vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: a systematic review and meta-analysis of randomized clinical trials – European Heart Journal (free)

“Compared with triple antithrombotic therapy, dual antithrombotic therapy shows a reduction in major or minor bleeding by 47% with comparable outcomes of major adverse cardiac events”.

 

6 – Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis – Neurology (free)

See also: Related Physician Tools and Materials (free clinician summary, slides and more)

Commentaries: New guideline: Start taking MS drugs early on – American Academy of Neurology, via EurekAlert (free) AND New MS Guideline Addresses Starting, Switching, and Stopping Disease-modifying Therapy – MD Magazine (free) AND Start MS Drugs Early, New Guideline Says – MedPage Today (free registration required)

 

7 – Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV – AIDSInfo (free)

 

8 – Richard Lehman’s journal review, 23 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – State of the Art Review: Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications – The BMJ (free for a limited period)

 

10 – Proton‐Pump Inhibitors and Long‐Term Risk of Community‐Acquired Pneumonia in Older Adults – Journal of the American Geriatrics Society (free)

Commentary: Commonly prescribed heartburn drug linked to Pneumonia in Older Adults – University of Exeter (free)

Related: Proton Pump Inhibitors: Review of Emerging Concerns – Mayo Clinic Proceedings (free) AND Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free) AND Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)

Source: Hospital Medicine Virtual Journal Club

 


 

1 – Report: WHO Expert Consultation on Rabies – World Health Organization (free)

News release: WHO publishes new rabies guidelines and recommendations on lifesaving immunization (free)

 

2 – Simplifying the use of prognostic information in traumatic brain injury – Journal of Neurosurgery

Part 1: The GCS-Pupils score: an extended index of clinical severity (free)

Part 2: Graphical presentation of probabilities (free)

Commentaries: New Glasgow Coma Scale–Pupils Score and Multifactor Probability Outcome Charts for Use in Patients with TBI – Journal of Neurosurgery, via NewsWise (free) AND New scoring system will speed up assessment of brain injuries – OnMedica (free) AND Glasgow Coma Scale Gets an Eye-Opening Update – Medscape (free registration required)

 

3 – Revised SAGE recommendation on use of dengue vaccine – World Health Organization (free)

Commentaries: A new dengue vaccine should only be used in people who were previously infected, WHO says – Science (free) AND WHO recommends testing before use of Sanofi’s dengue vaccine – Reuters (free)

 

4 – Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition – Cephalalgia (free PDF) (via @adamcifu)

News release and website: The International Classification of Headache Disorders 3rd edition (free)

Commentary: International Classification of Headache Disorders – The Lancet Neurology (free)

 

5 – Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder – Bipolar Disorders (free)

Related Guideline: Bipolar disorder: assessment and management – National Institute for Health and Care Excellence (free)

 

6 – Diagnosis and Management of Primary Aldosteronism: the Endocrine Society guideline 2016 revisited – European Journal of Endocrinology (free)

 

7 – Review: Hypokalemia: a clinical update – Endocrine Connections (free)

 

8 – Role of Immunotherapy in the Treatment of Asthma – Agency for Healthcare Research and Quality (free)

Source: EvidenceAlerts

 

9 – Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women: A Randomized Clinical Trial – JAMA (free)

Editorial: Nitrofurantoin vs Fosfomycin: Rendering a Verdict in a Trial of Acute Uncomplicated Cystitis – JAMA (free)

 

10 – Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Intranasal Esketamine Found Effective in Rapid Reduction of Depression, Suicidal Thoughts – Psychiatric News Alert (free) AND Fast-acting benefits of ketamine for depression and suicidality – American Psychiatric Association, via ScienceDaily (free) AND Ketamine ‘shows promise’ in treating depression – OnMedica (free) AND Ketamine Spray Effective for Suicidality, but Abuse Concerns Linger – Medscape (free registration required)

Related: ‘Cautious Optimism’ Marks Outlook for Ketamine, Mood Disorders – Psychiatric News (free)

 


 

1 – The “Top 12” Recommendations That Are Reducing Overuse – Choosing Wisely (free) (via @kennylinafp)

Learn more on the Choosing Wisely Initiative and see other lists of low-value practices in Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

2 – Choosing Wisely Campaigns: A Work in Progress – JAMA (free for a limited period) (via @ChooseWiselyCA  see Tweet)

 

3 – Association of Repeated Measurements With Blood Pressure Control in Primary Care – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Repeat BP Measurements in the Office Are Key, Study Highlights – TCTMD (free) AND Should Blood Pressure Measurement Be Repeated During Primary Care Visit? – MedicalResearch.com (free) AND Second BP Measurement Often Brings Better News – MedPage Today (free registration required) AND Repeated BP Measures Linked to Drop in Initially Elevated BP – Physician’s Weekly (free)

 

4 – Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer – Journal of Clinical Oncology (free)

Commentaries: Taking a Standard Prostate Cancer Drug with Food Boosts Impact, Lowers Cost – University of Chicago Medical Center, via NewsWise (free) AND Low-Dose Prostate Drug Can Match Standard Dose, Cut Costs – Medscape (free registration required)

Related: Tackling the High Cost of Cancer Care (free commentaries issued when this paper was first presented at the 2017 ASCO annual meeting)

“Savings per patient could reach as high as $300,000” (from NewsWise)

 

5 – Cancer treatment in the last 6 months of life: when inaction can outperform action – eCancer Medical Science (free)

 

6 – Debate on systematic reviews and meta-analyses: (via @trished)

Viewpoint 1: Are systematic reviews and meta-analyses still useful research? We are not sure – Intensive Care Medicine (free)

Viewpoint 2: Are systematic reviews and meta-analyses still useful research? Yes (free)

 

7 – Recommended Standard Care for People with Suicide Risk: Making Health Care Suicide Safe – National Action Alliance for Suicide Prevention (free PDF)

News Release: New Recommended Standard Care for People with Suicide Risk Aims to Fundamentally Improve Suicide Care Delivered Nationwide (free PDF)

Commentary: First-Ever Suicide Prevention Recommendations Released – Medscape (free registration required)

 

8 – Report: Multimorbidity: a priority for global health research – The Academy of Medical Sciences (free) (via @equitylist)

News Release: Global burden of multiple serious illnesses must be urgently addressed (free)

Commentaries: Burden of patients with multiple diseases could sink health systems around the world, warn medical experts – Independent (free) AND People with multiple health conditions get raw deal, says report – OnMedica (free)

See also: related articles on the Caring for High-Need, High-Cost Patients (free reports, articles and commentaries)

 

9 – Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Marijuana’s effects on young brains diminish 72 hours after use, research says – CNN (free) AND ‘Poorer Cognitive Functioning’ of Marijuana Users Detailed in New Study – Inverse (free)

 

10 – British HIV Association Standards of care for people living with HIV 2018 (free)

Commentary: New care standards for HIV aim to boost quality despite funding pressures – OnMedica (free)

 


 

1 – Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality – New England Journal of Medicine (free)

Editorial: The Value in an Ambulatory Blood-Pressure Registry (free)

Commentaries: Value of Ambulatory BP Monitoring Bolstered by Large Study – TCTMD (free) AND 24-hour ambulatory BP measurements strongly predict mortality – The Hospitalist (free) AND Expert reaction to study looking at blood pressure measurement method and predicting risk of heart disease – Science Media Centre (free)

 

2 – Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia – New England Journal of Medicine (free)

Editorial: Gene Therapy as a Curative Option for β-Thalassemia (free)

Quick Take Video Summary: LentiGlobin Gene Therapy for β-Thalassemia (free)

Commentaries: Gene therapy could free some people from a lifetime of blood transfusions – MIT Technology Review (free) AND Gene Therapy For Inherited Blood Disorder Reduced Transfusions – NPR (free) AND Expert reaction to study on gene therapy for beta-thalassaemia – Science Media Centre (free)

 

3 – A randomized trial of normothermic preservation in liver transplantation – Nature (free PDF for a limited period)

Commentaries: Room temperature liver storage technique improves transplant success – University of Oxford (free) AND Keeping livers ‘alive’ boosts transplant success, trial finds – BBC (free) AND A ‘breakthrough in organ preservation’: Study shows keeping livers warm helps preserve them for transplant – STAT (free)

 

4 – Viewpoint: Another Nail in the Coffin for Fish Oil Supplements – JAMA (free for a limited period)

 

5 – Time to challenge the spurious hierarchy of systematic over narrative reviews? – European Journal of Clinical Investigation (free) (via @kennylinafp and @Abraham_RMI)

 

6 – Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis – The BMJ (free)

Editorial: Closed loop systems in type 1 diabetes (free for a limited period)

 

7 – First-line drugs for hypertension – Cochrane Library (free)

Summary: Thiazides best first choice for hypertension – Cochrane Library (free)

 “First-line low-dose thiazides reduced all morbidity and mortality outcomes in adult patients with moderate to severe primary hypertension. First-line ACE inhibitors and calcium channel blockers may be similarly effective, but the evidence was of lower quality”.

 

8 – Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in people with coronary artery disease – Cochrane Library (link to abstract – $ for full-text)

Summary: Radial artery versus femoral artery approach for performing coronary catheter procedures in people with coronary artery disease – Cochrane Library (free)

“Transradial approach for diagnostic coronary angiography or PCI (or both) in CAD may reduce short-term net adverse clinical events, cardiac death, all-cause mortality, bleeding, and access site complications”.

 

9 – British Thoracic Society Quality Standards for acute non-invasive ventilation in adults – BMJ Open Respiratory Research (free)

Related Guidelines: Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting – Canadian Medical Association Journal (free) AND BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults – Thorax (free)

Source: Critical Care Reviews Newsletter

 

10 – Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Patients With Highest LDL Levels Benefit Most From Lipid-Lowering Drugs – MedicalResearch.com (free) AND New Study Finds that Statins Prevent Cardiovascular Deaths – Science Based Medicine (free) AND Meta-Analysis: ‘Floor’ for Lipid-Lowering Mortality Benefits May Be Real – MedPage Today (free registration required)

“In meta-analyses of LDL-C lowering drug trials, we found that total and cardiovascular mortality were reduced only when the mean baseline LDL-C in the trial was >100 mg/dl” (from MedicalResearch.com)

  


 

1 – Interventions to Prevent Falls in Community-Dwelling Older Adults: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Preventing Fractures and Falls: A Limited Role for Calcium and Vitamin D Supplements? (free) AND New Prevention Guidelines for Falls and Fractures—Looking Beyond the Letters (free)

Author Interview: USPSTF Recommendation: Calcium and Vitamin D to Prevent Fractures and Interventions to Prevent Falls in Community-Dwelling Adults (free)

Commentaries: Exercise, not vitamins, urged to prevent falls in seniors – MedicalXpress (free) AND Older adults may not need vitamin D to prevent falls and fractures – Reuters (free)

“Many older adults should avoid taking vitamin D and calcium supplements to prevent falls and fractures, and focus instead on exercises to improve balance and coordination, U.S. doctors recommend” (from Reuters)

 

2 – Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors With All-Cause Mortality in Patients With Type 2 Diabetes – JAMA (free)

Multimedia (2 minute video): Association Between Newer Antidiabetic Drug Classes and Mortality in Patients With Type 2 Diabetes (free)

Commentary: Diabetes drug may not reduce risk of death – Imperial College London (free)

 

3 – State of Global Air 2018 (free report and interactive website)

Commentaries: Over 7 Billion People Face Unsafe Air: State of Global Air 2018 – Institute for Health Metrics and Evaluation (free) AND More than 95% of world’s population breathe dangerous air, major study finds – The Guardian (free) AND More than 95% of world’s population breathing unhealthy air, says new report – CNN (free)

 

4 – Opinion: The Case Against Thrombolytic Therapy in Stroke – By John Mandrola, in Medscape (free registration required)

Related: For Many Strokes, There’s an Effective Treatment. Why Aren’t Some Doctors Offering It? – The New York Times (10 articles per month are free)

 

5 – Incremental Benefits and Harms of the 2017 American College of Cardiology/American Heart Association High Blood Pressure Guideline – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: New blood pressure guidelines may make millions anxious that they’re at risk of heart disease – The Conversation (free) AND New blood pressure guidelines could put lives at risk – The University of Sydney (free)

Related: AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free) AND The Hypertension Guideline War Is Not A Fake War – Cardiobrief (free) AND Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free)

 

6 – Nut consumption and incidence of seven cardiovascular diseases – Heart (free)

Commentary: Nuts May Be Good for the Heart, but Are Hardly a Miracle Food – The New York Times (10 articles per month are free)

 

7 – Clinical Guideline Synopsis: Management of Ventricular Arrhythmias and Sudden Cardiac Death Risk Related to Ischemic and Nonischemic Cardiomyopathy – JAMA (free for a limited period)

Original Guideline: 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death – Circulation (free PDF)

 

8 – Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review – Cochrane Library (free)

 

9 – Smoking even one cigarette a day raises risk for coronary heart disease – The Washington Post (a few articles per month are free) (via @DrFrieden see Tweet)

See original article: Meta-Analysis: Just One Cigarette a Day Seriously Elevates Cardiovascular Risk (free article and commentaries)

 

10 – Cardiovascular and Cerebrovascular Emergency Department Visits Associated With Wildfire Smoke Exposure in California in 2015 – Journal of the American Heart Association (free for a limited period)

Commentaries: Air quality linked to cardiac ‘events,’ heart disease patients unaware – Reuters (free) AND Wildfire smoke associated with more ER visits for heart, stroke ailments among seniors – American Heart Association, via ScienceDaily (free)

 


 

1 – Addressing Social Determinants to Improve Patient Care and Promote Health Equity: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

 

2 – Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology, 3rd edition – Gut (free)

Source: Hospital Medicine Virtual Journal Club

 

3 – Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentary: Atrial Fibrillation beyond “All or None”: The Missing Piece in Understanding Atrial Fibrillation? (free)

Top Ten Things to Know: Atrial Fibrillation Burden—Moving Beyond AF as a Binary Entity (free PDF)

 

4 – Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer – New England Journal of Medicine (free)

Commentaries: AACR 2018: Combination therapy doubles survival in metastatic lung cancer – eCancer News (free) AND Lung Cancer Patients Live Longer With Immune Therapy – New York Times (10 articles per month are free)

 

5 – Associations between chronotype, morbidity and mortality in the UK Biobank cohort – Chronobiology International (free)

Commentaries: ‘Night owls’ slightly more likely to die sooner than ‘early birds’ – NHS Choices (free) AND Why being a night owl may lead to earlier death – VOX (free) AND Night Owls Could Face Higher Risk Of Premature Death, Study Suggests – Forbes (free)

 

6 – Acid‐suppressive drugs and risk of kidney disease: A systematic review and meta‐analysis – Journal of Gastroenterology and Hepatology (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club

Proton pump inhibitors were associated with higher risks of acute interstitial nephritis (HR, 2.78; 95% CI, 1.25‐6.17), acute kidney injury (HR, 1.85; 95% CI, 1.33‐2.59), chronic kidney disease (HR, 1.47; 95% CI, 1.03‐2.09), and end‐stage renal disease (HR, 1.61; 95% CI, 1.26‐2.04) than non‐PPI therapy. Similar risks were not identified for H2RA therapy.

 

7 – Global burden of mental disorders among children aged 5–14 years – Child and Adolescent Psychiatry and Mental Health (free)

Commentary: Mental disorders among leading causes of illness in children worldwide – BioMed Central, via ScienceDaily (free)

 

8 – Richard Lehman’s journal review, 16 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – New Series from The Lancet Journals: Preconception health (free registration required)

Commentaries: Obese couples could be risking health of future children, studies say – The Guardian (free) AND Parents’ Preconception Well-Being Affects Child’s Future Health – Medscape (free registration required)

 

10 – The Risk of Fatigue and Sleepiness in the Ridesharing Industry: An American Academy of Sleep Medicine Position Statement – Journal of Clinical Sleep Medicine (free)

Commentary: AASM: Ridesharing Industry Needs to Do More to Promote Safety – MPR (free)

 


 

1 – Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies – The Lancet (free)

Editorial: Thresholds for safer alcohol use might need lowering (free)

Commentaries: Drinking a pint of beer may lower your life expectancy by the same amount as smoking a cigarette – new research – The Conversation (free) AND Expert reaction to study looking at drinking alcohol, life expectancy and alcohol limits – Science Media Centre (free) AND More than six weekly glasses of wine could curb life expectancy by up to five years – OnMedica (free) AND Consuming more than five drinks a week could shorten your life – University of Cambridge, via ScienceDaily (free) AND How much alcohol is too much? A new study says it’s found the number – PBS News Hour (free)

 

2 – Short-term Elevation of Fine Particulate Matter Air Pollution and Acute Lower Respiratory Infection – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentaries: Brief SExposure to Tiny Air Pollution Particles Triggers Childhood Lung Infections – Intermountain Medical Center, via NewsWise (free) AND Spikes in air pollution can heighten risk of chest infections, research suggests – The Guardian (free) AND Air Pollution May Pose Serious Risks to Young Children – The New York Times (10 articles per month are free) AND Short-Term Pollution Spikes Trigger Lung Infections in Young Kids – MedPage Today (free registration required)

 

3 – Primary care of adults with intellectual and developmental disabilities: 2018 Canadian consensus guidelines – Canadian Family Physician (free)

Related guideline: Care and support of people growing older with learning disabilities – National Institute for Health and Care Excellence (free)

 

4 – New affordable hepatitis C combination treatment shows 97 percent cure rate – Drugs for Neglected Diseases Initiative, via EurekAlert (free)

Related: Non-profit’s $300 hepatitis C cure as effective as $84,000 alternative – The Guardian (free) AND Hepatitis C: simplified curative treatments can drive global scale-up – World Health Organization (free)

 

5 – Association of Survival With Adherence to the American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors After Colon Cancer Diagnosis: The CALGB 89803/Alliance Trial – JAMA Oncology (free for a limited period)

Editorial: Helping Colorectal Cancer Survivors Benefit From Changing Lifestyle Behaviors: Implementation Science and Private Industry Collaboration to the Rescue (free for a limited period)

Commentaries: Colon Cancer Patients Who Follow a Healthy Lifestyle Have Longer Survival – NEJM Physician’s First Watch (free) AND Adherence to ACS Guidelines Linked to Survival in Colon Cancer – Physician’s Briefing (free)

 

6 – Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults – PLOS One (free)

Commentaries: Sitting Is Bad for Your Brain – Not Just Your Metabolism or Heart – University of California – Los Angeles, via NewsWise (free) AND Could Too Much Sitting Possibly Make Your Brain Thinner? – Forbes (free)

 

7 – n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease – New England Journal of Medicine (free for a limited period)

Commentaries: Omega-3s From Fish Oil Supplements No Better Than Placebo for Dry Eye – NIH, National Eye Institute (NEI), via NewsWise (free) AND Fish oil capsules don’t help dry eye symptoms, study finds – STAT (free) AND Fish oil supplements ineffective against dry eye – Reuters (free)

 

8 – The Clinical Trial Is Open. The Elderly Need Not Apply – The New York Times (10 articles per month are free)

Related: Cardiac Patients in Trials Don’t Reflect Real-World Populations (link to abstract and commentaries on the subject)

“There’s a shocking lack of data on effective treatments for older people. So what do doctors do? Make guesses”. (via @NYTHealth see Tweet)

 

9 – Gallstones: Watch and wait, or intervene? – Cleveland Clinic Journal of Medicine (free)

“Consider laparoscopic cholecystectomy for symptomatic cholelithiasis, expectant management for asymptomatic cases”.

 

10 – Effectiveness of a long-lasting piperonyl butoxide-treated insecticidal net and indoor residual spray interventions, separately and together, against malaria transmitted by pyrethroid-resistant mosquitoes: a cluster, randomised controlled, two-by-two factorial design trial – The Lancet (free)

Commentaries: Insecticide-resistant malaria vectors must be tackled – The Lancet (free) AND Advanced insecticidal nets protect against malaria, study shows – CIDRAP News Scan for Apr 12, 2018 (free) AND ‘Resistance breaking’ mosquito net provides children with greater protection against malaria – London School of Hygiene & Tropical Medicine (free)

“The novel net nearly halves malaria infection rate in Tanzanian children compared to standard long-lasting pyrethroid nets” (from London School of Hygiene & Tropical Medicine)

 


 

1 – Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentary: Taking the Good With the Bad – Assigning Value and Blame to the Right Heart in Cardiovascular Disease (free)

Top Ten Things to Know: Evaluation and Management of Right-Sided Heart Failure (free PDF)

 

2 – Protecting, promoting, and supporting breastfeeding in facilities providing maternity and newborn services: the revised Baby-friendly Hospital Initiative 2018 – World Health Organization, UNICEF (free)

News release: WHO and UNICEF issue new guidance to promote breastfeeding in health facilities globally (free)

Related guideline: Protecting, promoting and supporting breastfeeding in facilities providing maternity and newborn services – World Health Organization (free)

Commentary: Hospitals must support breastfeeding which saves lives – WHO, UNICEF – Reuters (free)

 

3 – Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis – Annals of Emergency Medicine (free)

Commentary: Meta-Analysis Favors Antibiotics After Drainage of Skin Abscesses – NEJM Journal Watch (free)

See related guideline with infographic: Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline – The BMJ (free) AND Meta-Analysis: Antibiotics for uncomplicated skin abscesses: systematic review and network meta-analysis – BMJ Open (free)

 

4 – Clinical Practice Guidelines for the Antibiotic Treatment of Community-Acquired Urinary Tract Infections – The Korean Society of Infectious Diseases and Korean Society for Chemotherapy (free)

 

5 – 2018 update of the EULAR recommendations for the management of Behçet’s syndrome – Annals of Rheumatic Disease (free)

Commentary: Behcet’s Syndrome: Treatment Guidelines Updated – MedPage Today (free registration required)

 

6 – The health, poverty, and financial consequences of a cigarette price increase among 500 million male smokers in 13 middle income countries: compartmental model study – The BMJ (free)

Editorial: The benefits of taxing cigarettes in middle income countries (free)

See also: To Improve Global Health, Tax the Things that are Killing Us (free policies, articles and commentaries) AND The Lancet Taskforce on NCDs and economics (free registration required for all articles and commentaries)

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: March 2018 – eCancer News (free)

 

8 – Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland – European Respiratory Journal (free)

Commentaries: Flu and pneumonia infections increase risk of having a heart attack and stroke – European Respiratory Foundation, via Eurekalert (free) AND Do Pneumococcal and Respiratory Virus Infections Trigger Cardiovascular Morbidity? – NEJM Journal Watch (free for a limited period)

See also: related study published recently showing a similar six-fold increase in myocardial infarctions in the week following a flu diagnosis (link to abstract and commentaries).

 

9 – Advanced machine learning in action: identification of intracranial hemorrhage on computed tomography scans of the head with clinical workflow integration – NPJ Digital Medicine (free) (via @EricTopol see Tweet)

 

10 – Risk of Unnatural Mortality in People With Epilepsy – JAMA Neurology (free for a limited period)

Editorial: Deaths in Epilepsy: What We Are Missing (free for a limited period)

Commentaries: Patients with epilepsy have greater risk of unnatural death – OnMedica (free) AND Epilepsy Diagnosis Tied to Suicide, Accident Risk – MedPage Today (free registration required)

 


 

1 – Zika Virus Shedding in Semen of Symptomatic Infected Men – New England Journal of Medicine (free)

Editorial: Virus in Semen and the Risk of Sexual Transmission (free)

Commentaries: New findings on Zika virus in semen may alter CDC guidance – CIDRAP (free) AND Study suggests risk of sexual transmission of Zika may dissipate quickly – STAT (free)

 

2 – American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis – Gastroenterology (free)

Source: New Clinical Practice Guidelines, April 2018 Edition – Medscape (free registration required)

Related guideline: Clinical practice guideline: management of acute pancreatitis – Canadian Journal of Surgery (free)

 

3 – Guideline: Lyme disease – National Institute for Health and Care Excellence (free)

News release: New advice will help doctors spot and treat Lyme disease early, says NICE (free)

 

4 – β-Amyloid accumulation in the human brain after one night of sleep deprivation – Proceedings of the National Academies of Sciences (free)

Commentaries: Don’t lose sleep over reports that one bad night can spark dementia – NHS Choices (free) AND One night of sleep deprivation leads to increase in Alzheimer’s protein – New Atlas (free) AND Expert reaction to study investigating sleep deprivation and amyloid build up – Science Media Centre (free)

 

5 – Long-term risk of dementia among people with traumatic brain injury in Denmark: a population-based observational cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Study confirms link between traumatic brain injury and dementia – UW Medicine, via EurekAlert (free) AND Traumatic brain injury increases risk of dementia – OnMedica (free) AND Brain injury may increase dementia risk – NHS Choices (free)

Related articles: Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study – PLOS One (free) AND Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football – JAMA (free)

 

6 – NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease – Alzheimer’s & Dementia (free)

Commentaries: Scientists Push Plan To Change How Researchers Define Alzheimer’s – NPR (free) AND Researchers Propose New Alzheimer’s Definition Based on Biomarkers – MedPage Today (free registration required) AND New biological research framework for Alzheimer’s seeks to spur discovery – NIH / National Institute on Aging, via EurekAlert (fee)

 

7 – Guideline: Evaluation and Management of Testosterone Deficiency – American Urological Association (free)

Commentary: AUA: New Guidelines for Diagnosis, Management of Testosterone Deficiency – MPR (free)

Related Guideline: Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free)

 

8 – Estimating the health and economic effects of the proposed US Food and Drug Administration voluntary sodium reformulation: Microsimulation cost-effectiveness analysis – PLOS Medicine (free)

Commentaries: FDA’s Proposed Sodium Reduction Plan Could Have a Big Impact, Analysis Suggests – TCTMD (free) AND US FDA sodium reformulation targets projected to save lives and costs – PLOS, via EurekAlert (free) AND Study highlights the health and economic benefits of a US salt reduction strategy – University of Liverpool (free)

 

9 – Investing in non-communicable disease prevention and management to advance the Sustainable Development Goals – The Lancet (free registration required)

See complete series: The Lancet Taskforce on NCDs and economics (free registration required for articles and commentaries)

“Economic case to #BeatNCDs: benefit-cost ratio of investing in prevention and treatment of #NCDs is 5.6 for economic returns – 10.9 if social returns are included” (via @TheLancet see Tweet)

 

10 – Effectiveness of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment versus their combination in prevention of depressive relapse or recurrence (DRD study): a three-group, multicentre, randomised controlled trial – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary: Preventive cognitive therapy is an effective alternative and addition to antidepressants for preventing depression relapse, study finds – ACP Internist (free) AND Preventive Cognitive Therapy Helps Limit Depression Recurrence – NEJM Physician’s First Watch (free) AND Depression: preventive cognitive therapy improves outcome in recurrent depression – Univadis (free registration required)

 


 

1 – Clinical Practice Guideline:  Iron Deficient Anemia – Toward Optimized Practice (TOP) (free PDF)

See also: Summary and Algorithm (free PDF)

Related: see all TOP Clinical Practice Guidelines, a practical resource for Family Physicians at the point of care.

 

2 – Dialysis Initiation and Mortality Among Older Veterans With Kidney Failure Treated in Medicare vs the Department of Veterans Affairs – JAMA Internal Medicine (free for a limited period)

Invited commentary: Appropriate Time for Chronic Dialysis Initiation: A Cause for Humility (free for a limited period)

Related articles: Treatment decisions for older adults with advanced chronic kidney disease – BMC Nephrology (free) AND Timing of Dialysis Initiation – What Has Changed Since IDEAL? – Seminars in Nephrology (free)

 

3 – Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Related article: Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Commentaries: Three-quarters of COPD cases are linked to childhood risk factors that are exacerbated in adulthood – The Lancet, via ScienceDaily (free) AND Early intervention may minimise later lung problems – The Melbourne Newsroom (free) AND COPD Risk Factors Evident Early in Life – NEJM Physician’s First Watch (free)

 

4 – Seminar: Malaria – The Lancet (free registration required)

 

5 – Perspective: Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)

 

6 – The burden of online friends: the effects of giving up Facebook on stress and well-being – The Journal of Social Psychology (free)

Commentaries: Quitting Facebook can reduce stress – University of Queensland (free) AND Giving up Facebook leads to a drop in the stress-related hormone cortisol, study finds – PsyPost (free) AND Does Quitting Facebook Really Make You Less Happy? Probably Not – Forbes (free) AND Want to de-stress? Delete Facebook, study suggests – Medical News Today (free)

 

7 – Alpha-blockers as medical expulsive therapy for ureteral stones – Cochrane Library (link to abstract – $ for full-text)

Summary: Alpha-blockers for ureteral stones in adult patients with symptoms of stone disease – Cochrane Library (free)

 

8 – Consolidated principles for screening based on a systematic review and consensus process – Canadian Medical Association Journal (free)

 

9 – AHA Policy Statement: Projected Costs of Informal Caregiving for Cardiovascular Disease: 2015 to 2035 – Circulation (free)

Commentary: Skyrocketing Costs of CVD Will Be Amplified by Informal Caregiving: AHA – TCTMD (free)

 

10 – Pharmaceutical Industry Payments and Oncologists’ Selection of Targeted Cancer Therapies in Medicare Beneficiaries – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Payments to Doctors Linked to Prescription Practices for Two Cancer Types – University of North Carolina (free) AND Pharma Dollars Appear to Sway Oncologist Rx Habits – MedPage Today (free registration required)