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NEWS - TOP 10 Medical News Stories

 

1 – Report: Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks – Agency for Healthcare Research and Quality (free)

See also: Evidence Summary (free PDF) AND Full Report (free PDF)

 

2 – NICE Guideline: Hearing loss in adults: assessment and management – National Institute for Health and Care Excellence (free)

 

3 – Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials – Rheumatology (free)

Commentary: OA: DMARDs fail to relieve pain in meta-analysis – Univadis (free registration required)

 

4 – Presented at EULAR 2018: NSAIDs Account for Large Part of Osteoarthritis-CVD Link, Study Suggests – TCTMD (free)

 

5 – Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Sodium Thiosulfate for Cisplatin-Induced Hearing Loss (free)

Commentaries: New drug halves hearing loss in children following cancer treatment – Cancer Research UK, via ScienceDaily (free) AND Otoprotectant Guards Against Cisplatin-Induced Hearing Loss – Medscape (free registration required) AND Antioxidant Cuts Hearing Loss in Cisplatin-Treated Kids – MedPage Today (free registration required)

 

6 – Review: What’s new in severe pulmonary embolism? – Intensive Care Medicine (free for a limited period) (via @srrezaie)

 

7 – Perspective: This Mediterranean diet study was hugely impactful. The science just fell apart – VOX (free)

See Related Retraction and Republication: PREDIMED Study on Mediterranean Diet (free article and commentaries)

 

8 – Perspective: To Fight Burnout, Organize – New England Journal of Medicine (free)

The social determinants of health — and physicians’ sense of powerlessness in the face of them — seem crucially missing from the discussion of burnout”.

 

9 – Review: Acute myocardial infarction in young women: current perspectives – International Journal of Women’s Health (free)

Related Review: Young Women With Acute Myocardial Infarction: Current Perspectives – Circulation: Cardiovascular Quality and Outcomes (free)

Related Guideline: Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association – Circulation (free)

 

10 – Review: Managing patients with chronic cough: challenges and solutions – Therapeutics and Clinical Risk Management (free)

See also recently published CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Cough Due to TB and Other Chronic Infections  (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)

 


 

1 – Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group – World Journal of Emergency Surgery (free)

 

2 – NICE Guideline: Dementia: assessment, management and support for people living with dementia and their carers – National Institute for Health and Care Excellence (free)

 

3 – The association of lifetime alcohol use with mortality and cancer risk in older adults: A cohort study – PLOS Medicine (free)

Commentaries: Risks of cancer and mortality by average lifetime alcohol intake – PLOS, via ScienceDaily (free) AND Drinking Alcohol Can Raise Cancer Risk. How Much Is Too Much? – NPR (free) AND Light drinkers at a lower combined risk of earlier death or developing cancer – The Conversation (free) AND Expert reaction to the association between lifetime drinking and mortality and cancer risk – Science Media Centre (free)

Related Meta-analysis: Risk Thresholds for Alcohol Consumption (free study, editorial and commentaries)

 

4 – Association of Stress-Related Disorders With Subsequent Autoimmune Disease – JAMA (link to abstract – $ for full-text)

Commentaries: Association of Stress-Related Disorders With Subsequent Autoimmune Disease – University of Iceland (free) AND Stress disorders tied to increased risk of autoimmune diseases – Reuters (free) AND Does Psychological Stress Trigger Autoimmune Disorders? – MedPage Today (free registration required)

 

5 – Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort – Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentaries: Diabetes may be an early manifestation of pancreatic cancer – eCancer News (free) AND Recent-onset diabetes linked to pancreatic cancer for some minorities – UPI (free) AND Diabetes after 50 could be early sign of pancreatic cancer, study says – CNN (free)

 

6 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentary: Ebola outbreak in Congo ‘largely contained’, says WHO – Reuters (free)

 

7 – The venous ulcer continues to be a clinical challenge: an update – Burns & Trauma (free)

Related Cochrane Review: Dressings and topical agents for treating venous leg ulcers (free) AND Summary (free)

 

8 – Long-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction – JAMA Surgery (free for a limited period)

Invited Commentary: Autologous vs Prosthetic Breast Reconstruction: Where Do We Stand? (free for a limited period)

Author Interview: Long-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction (free audio)

Commentaries: Breast reconstruction more satisfying than implants after cancer, survey says – UPI (free) AND Flap vs Implant for Breast Reconstruction: How to Choose – MedPage Today (free registration required) AND Study explores satisfaction, quality of life after breast reconstruction – Brigham and Women’s Hospital, via MedicalXpress (free)

 

9 – Idiopathic intracranial hypertension: consensus guidelines on management – Journal of Neurology, Neurosurgery & Psychiatry (free) 

 

10 – Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study – Journal of Clinical Psychopharmacology (link to abstract – $ for full-text)

Commentaries: Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants – MPR (free) AND Antidepressants tied to Parkinson’s-like symptoms – Univadis (free registration required)

“Observational study: Incidence of EPSs with antidepressants. RRs: duloxetine, 5.68; mirtazapine, 3.78; citalopram, 3.47; escitalopram, 3.23; paroxetine, 3.07; sertraline, 2.57; venlafaxine, 2.37; bupropion, 2.31; and fluoxetine, 2.03 (all significant)” (via @psychopharmacol see Tweet)

 


 

1 – Clinical Review Podcast (28 min): A Goal Too Far: Rethinking HbA1c Targets for Diabetes Treatment – JAMA Internal Medicine (free)

Related: For Patients with Type 2 Diabetes, What’s the Best Target Hemoglobin A1C? (Free Commentary, ADA Position Statement and ACP Guideline)

 

2 – Expert consensus document on the management of hyperkalaemia in patients with cardiovascular disease treated with renin angiotensin aldosterone system inhibitors: coordinated by the Working Group on Cardiovascular Pharmacotherapy of the European Society of Cardiology – European Heart Journal Cardiovascular Pharmacology (free)

 

3 – Comparison of prostatic artery embolisation (PAE) versus transurethral resection of the prostate (TURP) for benign prostatic hyperplasia: randomised, open label, non-inferiority trial – The BMJ (free)

Commentary: Prostatic artery embolisation: time to improve collaboration – The BMJ Opinion (free)

 

4 – Prevalence and outcomes of incidental imaging findings: umbrella review – The BMJ (free)

Related: Giles Maskell: Incidental anarchy – The BMJ Opinion (free)

“Incidentalomas. If you order imaging studies, you know they are a problem. This meta-analysis quantifies incidentaloma prevalence for specific types of imaging. For MRI of the brain, the prevalence was 22% (95%CI 14 to 31) (via @RasoiniR and @eloder, see Tweet)

 

5 – The Impact of the National HPV Vaccination Program in England Using the Bivalent HPV Vaccine: Surveillance of Type-Specific HPV in Young Females, 2010–2016 – The Journal of Infectious Diseases (free)

Commentaries: HPV vaccine leads to steep drop in cancer-causing infections in England – CNN (free) AND HPV vaccine has almost wiped out infections in young women, figures show – The Telegraph (free)

Related Cochrane Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer (link to review and commentaries)

 

6 – Commentary: IOTA – Liberal vs Conservative Oxygen Therapy in the Critically Ill – The Bottom Line (free)

Original Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)

“Hyperoxia is BAD –> Aim for lowest safest inspired O2 in critically ill pts & titrate FiO2 down if SpO2 >95%” (via @srrezaie see Tweet)

 

7 – Sex-specific relevance of diabetes to occlusive vascular and other mortality: a collaborative meta-analysis of individual data from 980 793 adults from 68 prospective studies – The Lancet Diabetes & Endocrinology (free)

Commentaries: Diabetes and cardiovascular mortality: the impact of sex – The Lancet Diabetes & Endocrinology (free) AND Diabetes triples women’s risk of death from ischemic heart disease – Cardiovascular Business (free)

 

8 – Influence of Lifestyle on Incident Cardiovascular Disease and Mortality in Patients With Diabetes Mellitus – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Healthy Lifestyle Lowers CVD Risk in Diabetes Patients – American College of Cardiology (free) AND Healthy lifestyle changes after diabetes diagnosis lower CVD risk – Cardiovascular Business (free) AND Reduction in CVD Events, Even Mortality, in Patients With Diabetes Who Adopt a Healthier Lifestyle – TCTMD (free)

 

9 – Prognostic Implications of Single-Sample Confirmatory Testing for Undiagnosed Diabetes: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Diagnosing Diabetes From a Single Blood Sample – Johns Hopkins Bloomberg School of Public Health, via NewsWise (free) AND One Blood Test Might Be Enough to Diagnosis (free) AND Diabetes Dx Predicted Accurately with Single Blood Sample – MedPage Today (free registration required) AND Diabetes Diagnoses Confirmable from Single-Sample Measurements – NEJM Physician’s First Watch (free)

“The standard practice of repeat blood tests may not always be necessary, a new study suggests” (from Johns Hopkins Bloomberg School of Public Health)

 

10 – Marital status and risk of cardiovascular diseases: a systematic review and meta-analysis – Heart (free)

Commentaries: Marriage tied to lower risk of fatal heart attacks and strokes – Reuters (free) AND Expert reaction to study looking at marital status and risk of heart disease, stroke and death – Science Media Centre (free)

 


 

1 – Just Released! ICD-11: Classifying disease to map the way we live and die – World Health Organization (free)

See also: ICD-11 is Here! – World Health Organization (free)

Browse: ICD-11 for Mortality and Morbidity Statistics (ICD-11 MMS), 2018 version – World Health Organization (free)

 

2 – Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free)

Related: Gaming addiction classified as mental health disorder by WHO – Reuters (free) AND WHO classifies ‘gaming disorder’ as mental health condition – CNN (free)

 

3 – European Heart Rhythm Association (EHRA) consensus document on management of arrhythmias and cardiac electronic devices in the critically ill and post-surgery patient – EP Europace (free)

 

4 – State of The Art Review: Secondary peritonitis: principles of diagnosis and intervention – The BMJ (free)

 

5 – Editorial: Helping patients choose wisely – The BMJ (free)

Related: The Choosing Wisely initiative was launched 6 years ago, and now has over 550 recommendations from 18 countries (free)

See complete lists from: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia / Choosing Wisely Canada

“One of the main barriers to tackling the problem of overuse is that doctors are concerned patients will find it difficult to accept fewer interventions. However, informed patients often opt for less intervention, not more.” (via @bmj_latest see Tweet)

 

6 – Guideline: Diagnosis and Management of Gastroesophageal Reflux in Preterm Infants – Pediatrics (free)

Commentaries: AAP Issues Guidance on Reflux in Preterm Infants – Medscape (free registration required) AND Pediatrics Group Offers Tips for Managing GERD in Preterm Infants – NEJM Physician’s First Watch (free)

 

7 – Effect of Tamsulosin on Passage of Symptomatic Ureteral Stones: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Editorial: Medical Expulsive Therapy for Ureteral Stones—Stone Age Medicine (free for a limited period)

Commentaries: Recent Clinical Trial Finds Tamsulosin Not Effective in Kidney Stone Passage – George Washington University, via NewsWise (free) AND For Passing Smaller Ureteral Stones, Tamsulosin May Be No Better Than Placebo – NEJM Physician’s First Watch (free)

 

8 – Richard Lehman’s journal review, 18 June 2018 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Hip arthroscopy versus best conservative care for the treatment of femoroacetabular impingement syndrome (UK FASHIoN): a multicentre randomised controlled trial – The Lancet (free)

Commentaries: Hip arthroscopy: an evidence-based approach – The Lancet (free) AND New surgery for groin pain found to be more effective than physiotherapy – University of Warwick (free)

 

10 – European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children

Consensus-based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part I – Journal of the European Academy of Dermatology and Venereology (free)

Consensus‐based European guidelines for treatment of atopic eczema (atopic dermatitis) in adults and children: part II – Journal of the European Academy of Dermatology and Venereology (free)

Commentary: New European guidelines issued for atopic dermatitis – Univadis (free registration required)

 


 

1 – British Thoracic Society Guideline for the initial outpatient management of pulmonary embolism (PE) – Thorax (free)

 

2 – Benefits and harms of screening men for abdominal aortic aneurysm in Sweden: a registry-based cohort study – The Lancet (free to abstract – $ for full-text)

Commentaries: Screening Programs for Abdominal Aortic Aneurysm Need a Rethink, Swedish Study Contends – TCTMD (free) AND Screening for aortic aneurysms in older men questioned – University of Gothemburg, via EurekAlert (free) AND Screening for Abdominal Aortic Aneurysm Questioned – NEJM Physician’s First Watch (free) AND Routine Aortic Aneurysm Screening Questioned – MedPage Today (free registration required)

 

3 – Clinical Trial of Fluid Infusion Rates for Pediatric Diabetic Ketoacidosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Does Infusion Rate Affect Neurologic Outcomes in Pediatric DKA? (free)

Commentaries: PEM Practice Changing Paper: Clinical Trial of Fluid Infusion Rates for Pediatric DKA – Aliem (free) AND The Rate of Resuscitation in Pediatric DKA – Emergency Medicine Literature of Note (free) AND Infusion Type Doesn’t Affect Brain Outcomes in Pediatric DKA – Medscape (free)

 

4 – Expert Analysis: ACS Management in a Patient in Need of Noncardiac Surgery – American College of Cardiology (free)

 

5 – Coronary Computed Tomography Angiography Versus Stress Echocardiography in Acute Chest Pain: A Randomized Controlled Trial – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentary: The Patient Presenting With Chest Pain: Stress Echo Gives Coronary CTA a Run for Its Money – TCTMD (free)

 

6 – Practice guideline update summary: Efficacy and tolerability of the new antiepileptic drugs – American Academy of Neurology and the American Epilepsy Society

Part I: Treatment of new-onset epilepsy (free PDF)

Part II: Treatment-resistant epilepsy (free PDF)

Commentary: New Epilepsy Guidelines Shed Light on Explosion of New Drugs – MedPage Today (free registration required)

 

7 – Palliative Care in the Global Setting: ASCO Resource-Stratified Practice Guideline – Journal of Global Oncology (free)

Commentary: ASCO Guideline Addresses Palliative Care in the Global Setting – ASCO Daily News (free)

 

8 – Age-attuned Hospice care: An opportunity to better end of life care for older people – StCristopher’s (free PDF) (via @hospicedoctor see tweet)

“Despite the evidence that more people will die of frailty and multiple long-term conditions than of cancer, our services for those moving towards the end of their life remain focussed on the needs of the latter group”

 

9 – Caring for the caregiver: A guide for physicians – American Medical Association (free PDF)

Commentary: AMA Releases New Physician Guide on Caring for the Caregiver – The ASCO Post (free)

 

10 – Association of Perioperative Red Blood Cell Transfusions With Venous Thromboembolism in a North American Registry – JAMA Surgery (free for a limited period)

Commentary: Peri-Op RBC Transfusions Linked to Postoperative VTE – MPR (free) AND Risk for Clot Increases After Surgery With Transfusion – Medscape (free registration required) AND Post-Op VTE Risk Up After Intra-Op Blood Transfusion – MedPage Today (free registration required) AND VTE Risk Higher in Surgical Patients Who Get Transfusions – TCTMD (free)

 


 

1 – Report: Noninvasive Nonpharmacological Treatment for Chronic Pain: A Systematic Review – Agency for Healthcare Research and Quality (free)

See also: Evidence Summary (free PDF) and Full Report (free PDF)

 

2 – The WHO essential diagnostic list: a tool for the future – BMJ Global Health Blog (free)

Related: The desperate global need for medical diagnostics – The Conversation (free) AND Health care is an essential human right – and so is a proper diagnosis – The Conversation (free)

See Original WHO Report: List of Essential In Vitro Diagnostics First edition (2018) – World Health Organization (free report and news release)

 

3 – Oral Fluconazole in Pregnancy and Risk of Stillbirth and Neonatal Death – JAMA (link to abstract – $ for full-text)

Commentaries: No link found between oral antifungal drug and stillbirth – Karolinska Institutet, via ScienceDaily (free) AND Antifungal Use During Pregnancy and Risk of Stillbirth: What’s the Link? – MPR (free) AND Study Finds No Link Between Fluconazole During Pregnancy and Stillbirth or Neonatal Death – MedicalResearch.com (free) AND Oral Fluconazole for Thrush in Pregnancy Doesn’t Up Stillbirth – Medscape (free registration required)

 

4 – Controversy: Is there still a place for the Swan-Ganz catheter?

YES (free for a limited period) / NO (free for a limited period) WE ARE NOT SURE (free for a limited period)

 

5 – Draft Recommendation Statement: Unhealthy Alcohol Use in Adolescents and Adults: Screening and Behavioral Counseling Interventions – U.S. Preventive Services Task Force (free)

Commentary: USPSTF Again Recommends Screening for Unhealthy Alcohol Use in Adults – NEJM Physician’s First Watch (free)

 

6 – Flynn effect and its reversal are both environmentally caused – Proceedings of the National Academy of Sciences (link to abstract – $ for full-text)

Commentaries: Researchers find IQ scores dropping since the 1970s – MedicalXpress (free) AND IQ Scores Are Falling in “Worrying” Reversal of 20th Century Intelligence Boom – Science Alert (free) AND IQ Scores Are Falling Due to Environmental Factors, Study Finds – TIME (free)

 

7 – Diagnosis and management of primary aldosteronism: the Endocrine Society guideline 2016 revisited – European Journal of Endocrinology (free)

Related Guideline: The Management of Primary Aldosteronism: Case Detection, Diagnosis, and Treatment: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free)

 

8 – Review: Optimal duration of dual antiplatelet therapy for coronary artery disease – Netherlands Heart Journal (free)

Related Guidelines: 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free) AND 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)

 

9 – Invasive Procedures Associated With the Development of Infective Endocarditis – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Infective endocarditis risk increased after many types of medical procedures – ACP Hospitalist (free) AND Many Invasive Procedures, Including Cardiovascular, Up Risk of Infective Endocarditis – TCTMD (free) AND Invasive procedures—including cardiovascular—boost risk of endocarditis – Cardiovascular Business (free) AND Endocarditis: Any Invasive Procedure Is a Risk – MedPage Today (free registration required)

 

10 – Effect of Increased Inpatient Attending Physician Supervision on Medical Errors, Patient Safety, and Resident Education: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Effect of increased inpatient attending physician supervision on medical errors, patient safety, and resident education: a randomized clinical trial – PSNet (free) AND Increased attending supervision on rounds didn’t significantly reduce medical errors – ACP Hospitalist (free) AND Additional physician resident supervision doesn’t improve patient safety – Modern Healthcare (free) AND Closer Resident Supervision Does Not Reduce Medical Errors – Medscape (free registration required) AND Is More Supervision of Medical Residents Always Better for Patient Care? – MedicalResearch.com (free)

 


 

1 – Effect of Negative Pressure Wound Therapy vs Standard Wound Management on 12-Month Disability Among Adults With Severe Open Fracture of the Lower Limb: The WOLLF Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: High-tech treatment of open leg wounds no better than using regular dressings – University of Warwick (free) AND Negative-Pressure Therapy No Better for Open Fractures – Medscape (free registration required)

“Negative pressure wound therapy did not improve 12-month disability for patients with severe open fracture of the lower limb compared with standard wound dressing”

 

2 – Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet Supplemented with Extra-Virgin Olive Oil or Nuts – New England Journal of Medicine (free)

Correspondence: Retraction and Republication: Primary Prevention of Cardiovascular Disease with a Mediterranean Diet. N Engl J Med 2013;368:1279-90 (free)

Commentaries: That Huge Mediterranean Diet Study Was Flawed. But Was It Wrong? – New York Times (free) AND Errors Trigger Retraction Of Study On Mediterranean Diet’s Heart Benefits – NPR (free) AND Expert reaction to retraction and republication of study looking at Mediterranean diet and heart disease – Science Media Centre (free)

 

3 – Dietary and nutritional approaches for prevention and management of type 2 diabetes – The BMJ (free)

 

4 – Perspective: The Search for Cancer Treatment Beyond Mutant-Hunting – The New York Times (10 articles per month are free)

 

5 – Effect of Dengue Serostatus on Dengue Vaccine Safety and Efficacy – New England Journal of Medicine (free)

Perspective: Trolleyology and the Dengue Vaccine Dilemma – New England Journal of Medicine (free)

Commentaries: Study confirms higher risk of dengue in kids who got Sanofi vaccine – Reuters (free) AND Sanofi’s new dengue challenge: find a diagnostic that will make its vaccine safe to use – STAT (free)

 

6 – Ebola Situation Report: Ebola Virus Disease in Democratic Republic of Congo – World Health Organization (free)

Related: More suspected DRC Ebola cases amid enhanced surveillance – CIDRAP (free) AND ‘We are still at war’ with Ebola: WHO chief – Reuters (free) AND Speedy Ebola tests help contain Africa’s latest outbreak – Nature News (free)

 

7 – Thrombocytopenia in the ICU: disseminated intravascular coagulation and thrombotic microangiopathies—what intensivists need to know – Critical Care (free)

 

8 – Guideline: Cancer of the upper aerodigestive tract: assessment and management in people aged 16 and over – National Institute for Health and Care Excellence (NICE) (free)

 

9 – Integrative Therapies During and After Breast Cancer Treatment: ASCO Endorsement of the SIO Clinical Practice Guideline – Journal of Clinical Oncology (free)

Commentary: Mozart, meditation and a yoga mat: Oncologists welcome integrative therapies for breast cancer – eCancer News (free)

 

10 – Association between systolic blood pressure and dementia in the Whitehall II cohort study: role of age, duration, and threshold used to define hypertension – European Heart Journal (free)

Commentaries: Dementia risk increased in 50-year-olds with blood pressure below hypertension threshold – European Society of Cardiology, via EurekAlert (free) AND Blood pressure below treatable threshold linked to heightened dementia risk – OnMedica (free) AND Studies: Higher blood pressure increases risk for dementia – UPI (free) AND High Blood Pressure at Age 50 Tied to Dementia Risk – The New York Times (10 articles per month are free) AND Dementia risk to 50-year-olds with raised blood pressure – study – The Guardian (free)

 


 

1 – Screening for Cardiovascular Disease Risk With Electrocardiography: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: The Screening ECG and Cardiac Risks (free) AND Screening for Cardiovascular Disease Risk With Electrocardiography (free)

JAMA Patient Page: Screening for Cardiovascular Disease Risk With ECG (free)

Author Interview: USPSTF Recommendation: Screening for Cardiovascular Disease Risk With Electrocardiography (free audio)

Commentaries: Doctors Told Not To Order Electrocardiograms For Low-Risk Patients – NPR (free) AND USPSTF Finds Insufficient Evidence For Preventative ECG Screening in Asymptomatic, Low-Risk Adults – American College of Cardiology (free) AND Do Not Screen Asymptomatic Adults For CVD With ECGs, Says USPSTF – TCTMD (free)

The USPSTF recommends against screening with resting or exercise electrocardiography (ECG) to prevent cardiovascular disease (CVD) events in asymptomatic adults at low risk of CVD events”.

 

2 – Prevalence of Prescription Medications With Depression as a Potential Adverse Effect Among Adults in the United States – JAMA (link to abstract – $ for full-text)

Commentaries: One-Third of US Adults May Unknowingly Use Medications That Can Cause Depression – University of Illinois at Chicago, via EurekAlert (free) AND Many U.S. adults take medicines that can cause depression – Reuters (free) AND Rx With Depression as Potential Adverse Effect Widely Used – Medscape (free registration required)

 

3 – Clinical Update: Antithrombotic Therapy for Peripheral Artery Disease in 2018 – JAMA (free for a limited period)

 

4 – Position Paper on Overdiagnosis and Action to be Taken – WONCA (free PDF) (via @RasoiniR)

Related: Overdiagnosis across medical disciplines: a scoping review – BMJ Open (free) Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free)

 

5 – The American Cancer Society public health statement on eliminating combustible tobacco use in the United States – CA: A Cancer Journal for Clinicians (free)

 

6 – A sleep prescription for medicine – The Lancet (free registration required)

“Junior doctors working a 34 h shift will make 460% more diagnostic mistakes than when well rested. Matthew Walker asks how can we change the culture of sleep within medicine?” (via @TheLancet see Tweet)

 

7 – Shaking hands is disgusting – here’s what else you can do – The Conversation (free)

Related: Handshake-free zones to prevent infections? (link to abstract and commentaries)

 

8 – Antiepileptic drugs in critically ill patients – Critical Care (free)

 

9 – Work stress and risk of death in men and women with and without cardiometabolic disease: a multicohort study – The Lancet Diabetes & Endocrinology (free)

Commentaries: Stress at work in patients with cardiometabolic disease – The Lancet Diabetes & Endocrinology (free) AND Job strain linked to heightened risk of early death in men with heart disease/diabetes – OnMedica (free) AND Work stress raises risk of premature death in vulnerable men – study – The Guardian (free) AND Job Strain as Bad as Smoking in Men With Diabetes, Heart Disease – Medscape (free registration required)

 

10 – Association of Viral Suppression With Lower AIDS-Defining and Non–AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Long-term viral suppression may help decrease cancer rates in patients with HIV – ACP Internist (free) AND Long Term HIV Viral Suppression Reduces But Does Not Eliminate Elevated Cancer Risk – MedicalResearch.com (free) AND Viral Suppression of HIV Tied to Less Cancer Risk – NEJM Physician’s First Watch (free)

 


 

1 – Burden of Streptococcus pneumoniae and Haemophilus influenzae type b disease in children in the era of conjugate vaccines: global, regional, and national estimates for 2000–15 – The Lancet Global Health (free)

Commentaries: Pneumococcal and Haemophilus influenzae type b disease: moving numbers in the right direction – The Lancet Global Health (free) AND 1.35 million children’s lives saved by HiB and pneumococcal vaccines since 2000 – Johns Hopkins University Bloomberg School of Public Health, via MedicalXpress (free) AND Dramatic reduction in two killer childhood diseases, study finds – The Telegraph (free)

 

2 – A Placebo-Controlled Trial of Bezafibrate in Primary Biliary Cholangitis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: A Trial of Bezafibrate in Primary Biliary Cholangitis – NEJM Resident 360 (free) AND Bezafibrate Normalizes Liver Enzymes in PBC – MedPage Today (free registration required)

“In a randomized trial of patients with primary biliary cholangitis, bezafibrate and ursodeoxycholic acid resulted in a higher rate of complete biochemical response than ursodeoxycholic acid alone” (via @NEJM see Tweet with visual abstract)

 

3 – Viewpoint: Type 2 Myocardial Infarction—Diagnosis, Prognosis, and Treatment – JAMA (free for a limited period)

Related Review: Type 2 myocardial infarction due to supply–demand mismatch – Trends in Cardiovascular Medicine (free)

 

4 – Viewpoint: Progress in Prevention and Treatment of Acute Kidney Injury: Moving Beyond Kidney Attack – JAMA (free for a limited period)

 

5 – Erectile Dysfunction as an Independent Predictor of Future Cardiovascular Events: The Multi-Ethnic Study of Atherosclerosis – Circulation (free PDF)

AHA News Release: Erectile dysfunction means increased risk for heart disease, regardless of other risk factors (free)

Commentaries: Men With Erectile Dysfunction Are Twice As Likely to Have Heart Disease, Study Says – TIME (free) AND Erectile Dysfunction Linked To Higher Chances Of Heart Problems In Men – Medical Daily (free)

 

6 – pH‐neutralizing esophageal irrigations as a novel mitigation strategy for button battery injury – The Laryngoscope (free)

Commentaries: Ingesting honey after swallowing button battery reduces injury and improves outcomes – Children’s Hospital of Philadelphia, via ScienceDaily (free) AND Honey + Sucralfate May Reduce Injury After Accidental Button Battery Ingestion – MPR (free)

 

7 – Richard Lehman’s journal review, 11 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Hydroxychloroquine: An old drug with new relevance – Cleveland Clinic Journal of Medicine (free)

Source: Hospital Medicine Virtual Journal Club

 

9 – New European Hypertension Guidelines Not in Harmony With US Guidance – TCTMD (free)

 

10 – A serious new hurdle for CRISPR: Edited cells might cause cancer, find two studies – STAT (free)

Related: Genome-editing tool could increase cancer risk – eCancer News (free) AND Gene editing tool may raise cancer risk in cells, scientists warn – Reuters (free) AND Expert reaction to using CRISPR/Cas9 and potential cancer risk in cells – Science Media Centre (free)

 


 

1 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for Anal Squamous Cell Cancers (Revised 2018) – Diseases of the Colon & Rectum (free)

 

2 – Association of Long-Term Risk of Respiratory, Allergic, and Infectious Diseases With Removal of Adenoids and Tonsils in Childhood – JAMA Otolaryngology-Head & Neck Surgery (free for a limited period)

Commentaries: Tonsillectomy in childhood raises risk of respiratory diseases – OnMedica (free) AND Tonsillectomy, Adenoidectomy in Childhood Tied to Long-Term Health Risks – Physician’s First Watch (free) AND Tonsillectomy Risks May Outweigh Benefits – The New York Times (10 articles per month are free)

 

3 – Opinion: The flu vaccine is being oversold – it’s not that effective – The Conversation (free)

See Related Cochrane Systematic Reviews: Vaccines for Preventing Influenza and Its Complications (free)

The infection rate in adults drops from 2% per year to 1%. You could say that’s halved, but it effectively only drops by 1%. So this means that out of every 100 healthy adults vaccinated, 99 get no benefit against laboratory confirmed influenza”.

 

4 – Outpatient Antibiotic Prescribing for Acute Respiratory Infections During Influenza Seasons – JAMA Network Open (free)

Commentaries: CDC study: Antibiotics still widely overused for respiratory infections – CIDRAP (free) AND Antibiotics Still Widely Prescribed for Viral ARIs – MedPage Today (free)

 

5 – High-Sensitivity Troponins and Outcomes After Myocardial Infarction – Journal of the American College of Cardiology (free for a limited period)

Commentary: High-Sensitivity Troponins and Outcomes After MI – American College of Cardiology (free) AND Advent of High-Sensitivity Troponin Tests in Sweden Leads to Only Small Uptick in MI Diagnoses – TCTMD (free)

The introduction of high-sensitive troponins was associated with an increased incidence of MI, although with no impact on survival.

 

6 – Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? – Journal of Hospital Medicine (free)

Source: Hospital Medicine Virtual Journal Club

 

7 – At one-month mark in Ebola outbreak, the focus shifts to remote areas – World Health Organization (free)

Related: WHO says Ebola situation in DRC shows promise – CIDRAP (free) AND WHO chief says Ebola outbreak in Congo is stabilizing – Reuters (free) AND An Encouraging Prediction About The Ebola Outbreak – NPR (free)

 

8 – Arrhythmia-Induced Cardiomyopathy – Deutsches Ärzteblatt international (free)

 

9 – Trends in State Suicide Rates — United States, 1999–2016 and Circumstances Contributing to Suicide — 27 States, 2015 – Centers for Disease Control and Prevention (free)

Commentaries: CDC: U.S. Suicide Rates Have Climbed Dramatically – NPR (free) AND CDC: Suicide rates rose 30% across nation since 1999 – UPI (free) AND More Americans Are Dying From Suicide – The Atlantic (free)

 

10 – Incidence of Diabetes After Cancer Development: A Korean National Cohort Study – JAMA Oncology (free for a limited period)

Commentaries: Diabetes risk increased by 9 cancers – eCancer News (free) AND Cancer Increases Risk of Developing Type 2 Diabetes, Study Finds – AJMC (free) AND Nine Cancers Linked to Diabetes Risk – Medscape (free registration required)

 


 

1 – 2018 Expert Consensus on the Management of Adverse Effects of Antiplatelet Therapy for Acute Coronary Syndrome in Taiwan – Acta Cardiologica Sinica (free)

 

2 – Building a Great Scientific Abstract: A Quick Checklist – by Hilda Bastian, in Absolutely Maybe Blog (free)

 

3 – Infographic: Global Deaths Attributable to High Systolic Blood Pressure, 1990-2016 – JAMA (free)

 

4 – Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free)

Related: University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

 

5 – Doctors Scrutinize Overtreatment, As Cancer Death Rates Decline – NPR (free)

 

6 – Community-level changes in condom use and uptake of HIV pre-exposure prophylaxis by gay and bisexual men in Melbourne and Sydney, Australia: results of repeated behavioural surveillance in 2013–17 – The Lancet HIV (free registration required)

Commentaries: Uptake of PrEP coincides with less condom use – OnMedica (free) AND PrEP uptake on the rise and condom use declines in gay men – News Medical (free) AND A pill that protects people from HIV may also lead to more sex without condoms – Science (free)

Related: How PrEP to Prevent HIV May be Fueling a Rise in Other STDs (link to abstract and commentaries)

 

7 – Education and myopia: assessing the direction of causality by mendelian randomization – The BMJ (free)

Editorial: Intense schooling linked to myopia (free)

Commentaries: Education and myopia: assessing the direction of causality by mendelian randomization – The BMJ Opinion (free) AND Myopia could be linked to longer periods spent in education – OnMedica (free) AND Highly Educated, Very Nearsighted? – The New York Times (10 articles per month are free)

 

8 – Job strain and atrial fibrillation – Results from the Swedish Longitudinal Occupational Survey of Health and meta-analysis of three studies – European Journal of Preventive Cardiology (free)

News Release: Stressful jobs are associated with a higher risk of heart rhythm disorders – European Society of Cardiology (free)

 

9 – Aspirin may be a follow-on option to prevent blood clots, starting five days after hip or knee surgery – NIHR Signal (free)

See Original Article: Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty – New England Journal of Medicine (link to abstract – $ for full-text) AND Quick Take Video Summary: Preventing VTE after Hip or Knee Arthroplasty (free)

 

10 – Effectiveness of targeted enhanced terminal room disinfection on hospital-wide acquisition and infection with multidrug-resistant organisms and Clostridium difficile: a secondary analysis of a multicentre cluster randomised controlled trial with crossover design (BETR Disinfection) – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentary: UV-light cleaning shown to cut superbugs hospital-wide – CIDRAP (free)

 


 

1 – Mental Health ATLAS 2017 – World Health Organization (free PDF)

News Release: Mental health: massive scale-up of resources needed if global targets are to be met (free)

See also: WHO Campaign on Mental Health (free resources)

Every US$ 1 invested in scaling up treatment for common mental illnesses such as depression and anxiety leads to a return of US$ 4 in better health and ability to work” (via @WHO see Tweet)

 

2 – Interventions for preventing upper gastrointestinal bleeding in people admitted to intensive care units – Cochrane Library (link to abstract – $ for full-text)

Summary: Interventions for preventing upper gastrointestinal bleeding in people on intensive care units – Cochrane Library (free)

Related Observational Study: H2 blockers prevented clinically important GI bleeding better than PPIs in ICU patients – ACP Hospitalist (free)

 

3 – Nicotine replacement therapy versus control for smoking cessation – Cochrane Library (free)

Summary: Can nicotine replacement therapy (NRT) help people quit smoking? – Cochrane Library (free)

 

4 – Perspective: Richard Smith: The case for medical nihilism and “gentle medicine” – The BMJ Opinion (free)

 

5 – Review: Aspiration Pneumonia and Related Syndromes – Mayo Clinic Proceedings (free)

 

6 – Ebola virus disease: Democratic Republic of the Congo – World Health Organization (free)

Related: DRC probes 5 new possible Ebola cases; WHO details experimental drugs – CIDRAP (free) AND Ebola treatments approved for compassionate use in current outbreak – World Health Organization (free) AND Ebola virus disease – Democratic Republic of the Congo: Points of Entry – World Health Organization (free)

 

7 – Stimulants for ADHD in children: Revisited – Therapeutics Initiative (via @AllenFrancesMD see Tweet)

“There is convincing evidence that a proportion of boys and girls treated with stimulants in BC and around the world are simply the youngest in their class”

 

8 – Review: Artificial Intelligence in Cardiology – Journal of the American College of Cardiology (free for a limited period)

Commentary: Reviews Examine How Digital, Mobile Advances Will Define Future of Cardiology – American College of Cardiology (free)

 

9 – Continuous low-dose antibiotic prophylaxis to prevent urinary tract infection in adults who perform clean intermittent self-catheterisation: the AnTIC RCT – Health Technology Assessment (free)

“The results of this large randomised trial, conducted in accordance with best practice, demonstrate clear benefit for antibiotic prophylaxis in terms of reducing the frequency of UTI for people carrying out CISC”.

 

10 – Association of Surgical Left Atrial Appendage Occlusion With Subsequent Stroke and Mortality Among Patients Undergoing Cardiac Surgery – JAMA (link to abstract – $ for full-text)

Commentary: Heart surgery: To have or not to have…your left atrial appendage closed – Mayo Clinic, via ScienceDaily (free) AND LAA Closure Tied to Better Heart Surgery Outcomes – MedPage Today (free registration required)

 


 

1 – Fecal Microbiota Transplantation for Primary Clostridium difficile Infection – New England Journal of Medicine (free)

Commentary: Antibiotics Weren’t Used to Cure These Patients. Fecal Bacteria Were – The New York Times (10 articles per month are free) AND The Latest Poop On Fecal Transplants Vs. Antibiotics For C. Difficile Diarrhea – Forbes (free)

 

2 – Association of Metformin Use With Risk of Lactic Acidosis Across the Range of Kidney Function: A Community-Based Cohort Study – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Study Supports Metformin Use at eGFRs as Low as 30 – NEJM Physician’s First Watch (free) AND Metformin safe for most diabetics with kidney disease – UPI (free) AND Evidence Growing Metformin Safe in Many With Diabetes and CKD – Medscape (free registration required)

Related Studies: Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease (link to abstract and commentaries) AND Metformin is linked to reduced mortality in type 2 diabetes with comorbid CKD and CHF – ACP Diabetes Monthly (free)

 

3 – #ASCO18 – Video (35 min): ASCO 2018 conference round up, by Dr Bishal Gyawali and Will Davies (free)

 

4 – #ASCO18 – Tailoring Adjuvant Endocrine Therapy for Premenopausal Breast Cancer – New England Journal of Medicine (free)

Editorial: Endocrine Adjuvant Therapy for Localized Breast Cancer (free)

Commentary: Aromatase Inhibitor Plus Ovarian Suppression Yields Benefit in High-Risk Premenopausal Patients With Breast Cancer – The ASCO Post (free)

 

5 – Perspective: Beyond Legalization — Dilemmas Physicians Confront Regarding Aid in Dying – New England Journal of Medicine (free)

 

6 – Understanding and Improving the Health of People Who Experience Incarceration: An Overview and Synthesis – Epidemiology Reviews (free)

 

7 – Pulmonary Function Tests for the Generalist: A Brief Review – Mayo Clinic Proceedings (free)

 

8 – Catch up on new COPD guidelines – ACP Internist (free)

Original Guideline: 2018 Global Strategy for Prevention, Diagnosis and Management of COPD – Global Initiative for Chronic Obstructive Lung Disease (GOLD) (free PDF)

Pocket Guide: COPD Diagnosis, Management and Prevention (free PDF)

 

9 – Exercise for cognitive brain health in aging: A systematic review for an evaluation of dose – Neurology Clinical Practice (link to abstract – $ for full-text)

Commentary: How Much Exercise Is Needed to Help Improve Thinking Skills? – American Academy of Neurology, via NewsWise (free) AND Exercise regimen can maintain cognition in older adults, researchers say – UPI (free) AND 1-Hour Exercise, 3 Times a Week Boosts Cognition in Older Adults – MedPage Today (free registration required)

 

10 – Clinical Implications of Revised Pooled Cohort Equations for Estimating Atherosclerotic Cardiovascular Disease Risk – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: New risk calculator could change the aspirin, statins, and blood pressure medications some people take – STAT (free) AND Statin recommendations may change, especially for African-Americans – CNN (free) AND Millions could have incorrect statin, aspirin and blood pressure prescriptions – Stanford Medicine, via ScienceDaily (free)

 


 

1 – More active people for a healthier world: The global action plan on physical activity 2018 – 2030 – World Health Organization (free PDF)

News Release: More active people for a healthier world: The global action plan on physical activity 2018 – 2030 (free resources)

 

2 – Time to deliver: report of the WHO Independent High-Level Commission on Noncommunicable Diseases – World Health Organization (free PDF)

News Release: Commission calls for urgent action against chronic diseases (free)

 

3 – #ASCO18 – PREOPANC-1 Trial Compares Preoperative Chemoradiotherapy vs Immediate Surgery for Pancreatic Cancer – The ASCO Post (free)

Related Video: Pre-operative chemotherapy with radiation may help people with pancreatic cancer live longer – eCancer News (free)

 

4 – #ASCO18 – Adjuvant mFOLFIRINOX vs Gemcitabine in Resected Pancreatic Cancer – The ASCO Post (free)

Related: Pancreatic Cancer Survival Jumps With Postsurgical Chemo Combo – OncLive (free) AND Study Finds Rare Gain for Tough-To-Treat Pancreatic Cancer – Associated Press (free)

 

5 – Current Concepts in Diagnosis and Treatment of Functional Neurological Disorders – JAMA Neurology (free for a limited period)

 

6 – Cardiac and Vascular Surgery–Associated Acute Kidney Injury: The 20th International Consensus Conference of the ADQI (Acute Disease Quality Initiative) Group – Journal of the American Heart Association (free)

 

7 – The management of chronic hepatitis C: 2018 guideline update from the Canadian Association for the Study of the Liver – Canadian Medical Association Journal (free)

Commentaries: Hepatitis C guideline recommends screening for all people born 1945-1975 – CMAJ, via EurekAlert (free) AND Canadian Group Offers New Guidelines on Hepatitis C Screening, Management – NEJM Physician’s First Watch (free)

Related Guidelines: HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C – American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) (free) AND EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)

 

8 – Richard Lehman’s journal review, 4 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Optimal pharmacological therapy in ST-elevation myocardial infarction—a review – Netherlands Heart Journal (free)

Source: Critical Care Reviews Newsletter

 

10 – Eliminating Inappropriate Telemetry Monitoring: An Evidence-Based Implementation Guide – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Continuing to Improve Appropriateness of Continuous Electrocardiographic Monitoring (Telemetry) (free for a limited period)

 


 

#ASCO18 – Highlights from the American Society of Clinical Oncology Annual Meeting 2018

 

1 – #ASCO18 – Adjuvant Chemotherapy Guided by a 21-Gene Expression Assay in Breast Cancer – New England Journal of Medicine (free)

Commentaries: 2018 ASCO: TAILORx: Most Women With Early-Stage Breast Cancer Can Forgo Chemotherapy When Guided by a Diagnostic Test – The ASCO Post (free) AND Many breast cancer patients can skip chemo, big study finds – STAT (free) AND Many women with early-stage breast cancer can skip chemotherapy: study – Reuters (free) AND For Some Breast Cancer Patients, The Chemo Decision Just Got Easier – NPR (free) AND Breast cancer: Test means fewer women will need chemotherapy – BBC (free) AND Good News for Women With Breast Cancer: Many Don’t Need Chemo – The New York Times (10 articles per month are free)

 

2 – #ASCO18 – Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2016: A Systematic Analysis for the Global Burden of Disease Study – JAMA Oncology (free)

Commentary: Increase in lifestyle-related cancers over past decade spotlights critical need for prevention – Institute for Health Metrics and Evaluation (free)

 

3 – #ASCO18 – Sunitinib Alone or after Nephrectomy in Metastatic Renal-Cell Carcinoma – New England Journal of Medicine (free)

Editorial: Cytoreductive Nephrectomy — Patient Selection Is Key (free)

Commentaries: 2018 ASCO: Carmena Trial Compares Nephrectomy Plus Adjuvant Sunitinib vs Sunitinib Alone in Metastatic RCC – The ASCO Post (free) AND In Advanced Kidney Cancer, Surgery No Longer Sole Standard of Care – Medscape (free registration required)

 

4 – #ASCO18 – Pembrolizumab (pembro) versus platinum-based chemotherapy (chemo) as first-line therapy for advanced/metastatic NSCLC with a PD-L1 tumor proportion score (TPS) ≥ 1%: Open-label, phase 3 KEYNOTE-042 study (link to abstract)

Commentaries: 2018 ASCO: KEYNOTE-042 Trial Compares Pembrolizumab With Chemotherapy as First-Line Treatment of NSCLC With PD-L1 Expression of 1% or More – The ASCO Post (free) AND ‘End of an Era’ for Chemo in Non-Small Cell Lung Cancer – Medscape (free registration required)

 

5 – #ASCO18 – Phase 3 Trial of Ibrutinib plus Rituximab in Waldenström’s Macroglobulinemia – New England Journal of Medicine (free)

Commentary: Ibrutinib/Rituximab Improves PFS in Waldenström’s Macroglobulinemia – ASCO Daily News (free)

 

6 – #ASCO18 – Affordability and Price Increases of New Cancer Drugs in Clinical Guidelines, 2007–2016 – Cancer Spectrum (free) (via @oncology_bg see Tweet)

 

7 – #ASCO18 – Editorial: Marketing personalized cancer treatments requires careful language – Nature (free)

Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)

“Therapies tailored to individual tumors must not be oversold”.

 

8 – #ASCO18 – 2018 ASCO: Low-Dose Maintenance Chemotherapy in Rhabdomyosarcoma – The ASCO Post (free)

 

9 – #ASCO18 – 2018 ASCO: Blood Test Shows Potential as a Detection Tool for Early-Stage Lung Cancer – The ASCO Post (free)

Commentary: Biotech Firm Grail Takes The First Steps In Its Quest For A Blood Test For Cancer – Forbes (free)

 

10 – #ASCO18 – Antibiotics greatly reduce effectiveness of cancer treatment – study – The Guardian (free) AND Antibiotics HALVE life expectancy of cancer sufferers, NHS medics reveal in world first at US conference – Daily Maily (free)

 


 

1 – World No Tobacco Day, 31 May 2018 – World Health Organization (free resources)

Related: World No Tobacco Day: Tobacco and Heart Disease – World Health Organization (free)

Commentary: Smoking down, but tobacco use still a major cause of death, disease – WHO – Reuters (free)

 

2 – Electronic cigarette use in youths: a position statement of the Forum of International Respiratory Societies – European Respiratory Journal (free)

News Release: Respiratory societies warn about electronic cigarette use in youth: World No Tobacco Day – CHEST (free)

 

3 – National, regional, and global prevalence of smoking during pregnancy in the general population: a systematic review and meta-analysis – The Lancet Global Health (free)

Invited Commentary: A global perspective on smoking during pregnancy (free)

 

4 – Cancer screening in the United States, 2018: A review of current American Cancer Society guidelines and current issues in cancer screening – CA: A Cancer Journal for Clinicians (free)

See Also Cancer Screening Guidelines from Other Organizations: U.S. Preventive Services Task Force Recommendations (all free) AND Canadian Task Force on Preventive Health Care Published Guidelines (all free)

 

5 – Clinical practice guidelines for the management of central venous catheter for critically ill patients – Journal of Emergency and Critical Care Medicine (free)

Source: Critical Care Reviews Newsletter

 

6 – Perspective by Bill Gates: Innovation for Pandemics – New England Journal of Medicine (free)

Related: The Characteristics of Pandemic Pathogens: Improving Pandemic Preparedness by Identifying the Attributes of Microorganisms Most Likely to Cause a Global Catastrophic Biological Event – Johns Hopkins Bloomberg School of Public Health (free PDF) AND Are we prepared for the looming epidemic threat? – The Guardian (free) The World Is Not Ready for the Next Pandemic – TIME cover story AND The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) AND Seven reasons we’re at more risk than ever of a global pandemic – CNN (free) AND Video: Pandemics – a worrying global public health threat (free)

 

7 – Symptomatic Zika Virus Infection in Infants, Children, and Adolescents Living in Puerto Rico – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: New studies highlight Zika presentation in kids, veterans – CIDRAP (free) AND Postnatal Zika in Kids Marked by Mild Symptoms – MedPage Today (free registration required)

 

8 – Global mental health: five key insights which emerge from the data – Our World in Data (free)

 

9 – It’s time to rethink how much booze may be too much – VOX (free)

Related Meta-Analysis: Risk Thresholds for Alcohol Consumption (free article, editorial and commentaries)

 

10 – Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study – The BMJ (free)

 


 

1 – International Expert Consensus Document on Takotsubo Syndrome: (via @JGrapsa and @TomLuscher)

Part I: Clinical Characteristics, Diagnostic Criteria, and Pathophysiology – European Heart Journal (free)

Part II: Diagnostic Workup, Outcome, and Management – European Heart Journal (free)

 

2 – Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society – CA: A Cancer Journal for Clinicians (free)

News Release: American Cancer Society Updates Colorectal Cancer Screening Guideline (free)

Commentaries: American Cancer Society recommends earlier colorectal cancer screening – Reuters (free) AND American Cancer Society advises colorectal screens at 45, not 50 – UPI (free) AND Cancer Group Calls for Colorectal Cancer Screening Starting at Age 45 – The New York Times (10 articles per month are free) AND Get Screened Earlier For Colorectal Cancer, Urges American Cancer Society – NPR (free)

Related Guidelines (all suggest screening should begin at age 50 years in average-risk individuals): Colorectal Cancer Screening – U.S. Preventive Services Task Force (free resources) AND Recommendations on screening for colorectal cancer in primary care – Canadian Task Force on Preventive Health Care (free) AND Colorectal Cancer Screening: Recommendations for Physicians and Patients from the U.S. Multi-Society Task Force on Colorectal Cancer – The American Journal of Gastroenterology (free)

 

3 – Type 2 diabetes mellitus in older people: a brief statement of key principles of modern day management including the assessment of frailty. A national collaborative stakeholder initiative – Diabetic Medicine (free)

Commentary: New guidance on treating diabetes in elderly and frail adults – University of Exeter, via EurekAlert (free)

 

4 – Diabetes Canada Position Statement for People with Types 1 and 2 Diabetes Who Fast During Ramadan – Canadian Journal of Diabetes (free)

 

5 – For Patients With Type 2 Diabetes, What’s the Best Target Hemoglobin A1C? – JAMA (free for a limited period)

Related: A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks – Diabetes Care (free) AND Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)

 

6 – Things We Do For No Reason: Neutropenic Diet – Journal of Hospital Medicine (free) (via @guptaarjun90 and @AnilMakam)

 

7 – Sugar, tobacco, and alcohol taxes to achieve the SDGs – The Lancet (free registration required)

Commentary: Sugar, tobacco, and alcohol taxes to achieve the Sustainable Development Goals – London School of Hygiene & Tropical Medicine (free)

Related: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND To improve global health, tax the things that are killing us (free articles, commentaries and reports) AND The Lancet taskforce on NCDs and economics (free series and commentaries)

 

8 – Ebola vaccine provides protection and hope for high-risk communities in the Democratic Republic of the Congo – World Health Organization (free)

Related: Ebola cases drop as more specimens test negative – CIDRAP (free)

 

9 – Intake of Different Dietary Proteins and Risk of Heart Failure in Men – Circulation (free)

Commentaries: High protein diet associated with small increased heart failure risk in middle-aged men – AHA Newsroom (free) AND High-Protein Diets May Slightly Increase The Risk Of Heart Disease – Forbes (free)

 

10 – Lifetime Smoking History and Risk of Lung Cancer: Results From the Framingham Heart Study – Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentaries: Risk of Incident Lung Cancer Drops by 39% Five Years After Smokers Quit – AJMC (free) AND New research finds lung cancer risk drops substantially within five years of quitting – Vanderbilt University Medical Center, via eCancer News (free)

 


 

1 – Man against machine: diagnostic performance of a deep learning convolutional neural network for dermoscopic melanoma recognition in comparison to 58 dermatologists – Annals of Oncology (free)

Commentaries: AI surpasses dermatologists at diagnosing skin cancer – ESMO, via eCancer News (free) AND Computer learns to detect skin cancer more accurately than doctors – The Guardian (free) AND A.I. better at diagnosing skin cancer than humans – OnMedica (free)

 

2 – It Saves Lives. It Can Save Money. So Why Aren’t We Spending More on Public Health? – The New York Times (10 articles per month are free)

Related: Return on investment of public health interventions: a systematic review – Journal of Epidemiology & Public Health (free)

Source: Global Health NOW Newsletter

 

3 – How is the world doing in its fight against vaccine preventable diseases? – Our World in Data (free)

“Vaccines are amazing: the number of child deaths caused by diseases for which vaccines are available fell by over 2/3 in 25 years. 3.6 million(!) fewer kids under the age of 5 died from these diseases in 2015 than in 1990” (via @DinaPomeranz see Tweet)

 

4 – Viewpoint: Big Data and Predictive Analytics: Recalibrating Expectations – JAMA (free for a limited period)

 

5 – Richard Lehman’s journal review, 29 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

6 – Has suicide become an occupational hazard of practicing medicine? – CMAJ News (free)

Related: Preventing physician suicide – ACP Hospitalist (free) AND What I’ve learned from my tally of 757 doctor suicides – The Washington Post (free) AND Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT (free) AND Protecting interns and other physicians from depression and suicide – STAT (free)

“Our work environments are unhealthy and it’s supported by a culture of giving and made worse in modern times by a culture of efficiencies and bureaucracies”

 

7 – The Endless Days Of A Young Doctor Battling Ebola – NPR (free)

Other Stories on the Ebola Outbreak: Ebola outbreak response shifts to remote DRC hot spots – CIDRAP (free) AND New Ebola Outbreak in Africa Is a Major Test for the WHO – JAMA Forum (free) AND WHO’s Congo Ebola plan assumes 100-300 cases over three months – Reuters (free) AND Ebola outbreak 2018: What’s different this time? – CNN (free) AND More regions to be vaccinated, experimental drugs to be tried in Congo Ebola outbreak – CNN (free)

 

8 – Association of State Alcohol Policies With Alcohol-Related Motor Vehicle Crash Fatalities Among US Adults – JAMA Internal Medicine (free for a limited period)

Editorial: Effective Alcohol Policies—Saving Lives on US Roadways (free)

Commentary: Stricter state alcohol access rules can save 800 DUI deaths a year, study says – CNN (free) AND Stronger alcohol policies help reduce alcohol-related crash deaths in US – Boston University, via EurekAlert (free)

 

9 – Unfinished Journey: The Global Health Response to Children & Road Traffic – FIA Foundation (free PDF)

News Release: Call for urgent action as ‘fatal disconnect’ in global health policies fails child victims of road traffic (free)

Source: International Health Policies Newsletter

 

10 – Association Between Vitamin D Supplementation During Pregnancy and Offspring Growth, Morbidity, and Mortality: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free)

Editorial: Prenatal Vitamin D Supplementation to Improve Health in Offspring (free)

Commentary: Vitamin D Supplementation of Moms Linked to Better Outcomes for Newborns – Physician’s First Watch (free)

 


 

1 – Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)

See also: NEJM Tweet with visual abstract

There is something very disturbing about a trial with HR=0.76, 95% CI 0.55-1.04 for the primary endpoint being stopped early for futility”. This TWEETORIAL by @ADAlthousePhD is a huge help in interpreting the results of this important trial (see more on the rise of “Tweetorial” here).

 

2 – Review: Supplemental Vitamins and Minerals for CVD Prevention and Treatment – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Most vitamin, mineral supplements not shown to lower heart disease risk – American College of Cardiology, via ScienceDaily (free) AND Aside From Folate, Vitamins Appear Largely Ineffective For Prevention, Study Finds – Forbes (free) AND Most popular vitamin and mineral supplements provide no health benefit, study finds – St. Michael’s Hospital, via EurekAlert (free)

 

3 – Perspective: Incidental anarchy – The BMJ Opinion (free)

“Giles Maskell writes on over diagnosis and underdiagnosis, the complexities of incidental findings and urges clinicians to “Think before you scan because you can” (via @bmj_latest see Tweet)

 

4 – Review: Management of cardiogenic shock complicating myocardial infarction – Intensive Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

 

5 – Advanced heart failure: a position statement of the Heart Failure Association of the European Society of Cardiology – European Journal of Heart Failure (free PDF)

 

6 – Women’s Health Policy in the United States: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

Commentary: U.S. doctors call for health policies that support women – Reuters (free)

 

7 – Concomitant fibromyalgia complicating chronic inflammatory arthritis: a systematic review and meta-analysis – Rheumatology (free)

Commentary: Comorbid fibromyalgia common in patients with inflammatory arthritis – MedwireNews (free)

 

8 – How common is alcohol and drug dependency across the world? – Our World in Data (free)

 

9 – Online Atlas: The 2018 Atlas of Sustainable Development Goals – The World Bank (free)

Download PDF: The 2018 Atlas of Sustainable Development Goals – The World Bank (free)

News Release: The 2018 Atlas of Sustainable Development Goals: an all-new visual guide to data and development (free)

 

10 – World Health Organization-World Federation of Societies of Anaesthesiologists (WHO-WFSA) International Standards for a Safe Practice of Anesthesia – Canadian Journal of Anesthesia (free)

Commentaries: International anesthesia standards updated with WHO in global effort to improve surgical care – World Health Organization-World Federation of Societies of Anaesthesiologists, via EurekAlert (free)

 


 

1 – HCV Guidance: Recommendations for Testing, Managing, and Treating Hepatitis C – American Association for the Study of Liver Diseases (AASLD) and the Infectious Diseases Society of America (IDSA) (free)

News Release: HCV Guidance Updates Recommendations for Screening and Treating Key Populations (free)

Related Guideline: EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)

 

2 – A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks – Diabetes Care (free) (via @Abraham_RMI)

Related guideline: Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)

 “Clinicians should aim to achieve an HbA1c level between 7% and 8% in most patients with type 2 diabetes” (from ACP Guideline, prompting the Editorial)

 

3 – Latest Developments on the Ebola Outbreak in DRC:

Vaccinations set to begin in Ebola outbreak epicenter – STAT (free) AND Research during Ebola vaccine trial: It’s complicated – Science (free) AND New Ebola Tactics Raise Hope but May Sow Confusion – The New York Times (10 articles per month are free) AND Ebola outbreak in DRC on ‘epidemiological knife-edge,’ says WHO official – Devex (free) AND The success of the new Ebola vaccine will hinge on trust – VOX (free)

 

4 – Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy – Annals of Intensive Care (free) (via @Fluid_Academy)

Related Review: Expert statement for the management of hypovolemia in sepsis – Intensive Care Medicine (free)

 

5 – Perspective: QALYs in 2018—Advantages and Concerns – JAMA (free for a limited period)

 

6 – Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments: A Scientific Statement From the American Heart Association (free PDF)

Commentary: Appreciating Cardiovascular Disease Risk in South Asians: The Time is Now (free)

Top Ten Things to Know: Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments (free PDF)

AHA News: South Asians’ high risk of cardiovascular disease has been hidden by a lack of data (free)

News Release: South Asian Americans are at high risk for heart disease and stroke (free)

 

7 – Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study – JAMA Neurology (free for a limited period)

Commentaries: Vascular risk interacts with amyloid levels to increase age-related cognitive decline – Massachusetts General Hospital, via ScienceDaily (free) AND Bad Synergy—Together, Vascular Problems and Aβ Hasten Memory Slippage – AlzForum (free) AND Combo of vascular risk, brain amyloid could quicken mental decline – Cardiovascular Business (free)

 

8 – Association of Low-Fat Dietary Pattern With Breast Cancer Overall Survival: A Secondary Analysis of the Women’s Health Initiative Randomized Clinical Trial – JAMA Oncology (free)

Commentaries: Low-fat Diet May Improve Overall Survival in Newly Diagnosed Breast Cancer – Oncology Nurse Advisor (free) AND Low-fat diet reduces risk of breast cancer death – NHS Choices (free)

 

9 – Antidepressant utilisation and incidence of weight gain during 10 years’ follow-up: population based cohort study – The BMJ (free)

Editorial: Antidepressant induced weight gain (free)

Commentaries: Antidepressant therapy and risk of weight gain – The BMJ Opinion (free) AND Taking antidepressants could be linked to weight gain, according to a new study — and some drugs heighten the risk more than others – Business Insider (free) AND Antidepressants linked to risk of weight gain, study shows – OnMedica (free) AND Antidepressant use linked with weight gain – NHS Choices (free)

 

10 – Committee Opinion: Gynecologic Care for Adolescents and Young Women With Eating Disorders – American College of Obstetricians and Gynecologists (free)

News Release: Ob-Gyns Have Important Role on Care Team for Women with Eating Disorders – ACOG (free)

Commentary: OB/GYN Group Offers Advice on Caring for Teens, Young Women with Eating Disorders – Physician’s First Watch (free)

 


 

1 – Report: Diet, Nutrition, Physical Activity and Cancer: a Global Perspective – World Cancer Research Fund (free)

Commentaries: A blueprint to beat cancer – World Cancer Research Fund (free) AND 10-year study shows obesity increases risk for 12 cancers – UPI (free)

 

2 – Metastatic Pancreatic Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Related Guideline: Pancreatic cancer in adults: diagnosis and management – National Institute for Health and Care Excellence (free)

Related Systematic Review: Chemotherapy and radiotherapy for advanced pancreatic cancer – Cochrane Library (free)

 

3 – Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Suspected Acute Venous Thromboembolic Disease – American College of Emergency Physicians (free)

Summary: ACEP Clinical Policy on Acute VTE 2018 – R.E.BE.L.em (free)

Related: Should We Anticoagulate Patients with Isolated Subsegmental Pulmonary Emboli? – NEJM Journal Watch (free)

 

4 – Review: The art of cardiovascular risk assessment – Clinical Cardiology (free)

 

5 – Review: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults – European Journal of Endocrinology (free)

 

6 – Europe’s open-access drive escalates as university stand-offs spread – Nature News (free)

 

7 – Perspective: How Tech Can Turn Doctors Into Clerical Workers – The New York Times Magazine (10 articles per month are free)

“The threat that electronic health records and machine learning pose to physicians’ clinical judgment — and their well-being”.

 

8 – New Free Online Course: Introduction to Critical Care Medicine – University of Glasgow and FutureLearn (free) (via @classcentral)

 

9 – Severe and predominantly active atopic eczema in adulthood and long term risk of cardiovascular disease: population based cohort study – The BMJ (free)

Editorial: Atopic eczema and cardiovascular disease (free)

Commentaries: Severe eczema and increased risk of cardiovascular problems – The BMJ Opinion (free) AND Severe eczema linked to cardiovascular problems – OnMedica (free) AND People with severe eczema at higher risk of heart conditions – NHS Choices (free)

 

10 – Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women – Journal of the American Heart Association (free for a limited period)

Editorial: Cardiovascular Sequels of Hypertension in Pregnancy (free for a limited period)

Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries)

 


 

1 – A Pragmatic Trial of E-Cigarettes, Incentives, and Drugs for Smoking Cessation – New England Journal of Medicine (free)

Commentaries: Money a better motivator to stop smoking than free e-cigs or quit aids – Reuters (free) AND E-cigarettes aren’t better at helping smokers quit than other strategies – Journalist’s Resource (free) AND For Smoking Cessation, Money Whispers Louder than Nicotine Replacement – MedPage Today (free registration required)

“Trial finds financial incentives most effective – but nothing very effective” (from MedPage Today)

 

2 – A Randomized Trial of a Family-Support Intervention in Intensive Care Units – New England Journal of Medicine (free)

Editorial: Nurse-Led Communication in the Intensive Care Unit (free)

Commentary: Team Approach to Support Families Improves ICU Patient-Centered Care and Lowers Costs – University of Pittsburg (free)

 

3 – Practical Assessment and Management of Vulnerabilities in Older Patients Receiving Chemotherapy: ASCO Guideline for Geriatric Oncology – Journal of Clinical Oncology (free)

 

4 – Advocating for Life Support Training of Children, Parents, Caregivers, School Personnel, and the Public – Pediatrics (free)

Summary: Advocating for Life Support Training of Children, Parents, Caregivers, School Personnel, and the Public (free)

News Release: AAP policy says more people need access to life support training, AEDs (free)

Commentary: AAP: Children can be educated in assisting those in cardiac arrest – Healio (free registration required)

 

5 – Estimating the Association of the 2017 and 2014 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults: An Analysis of National Data – JAMA Cardiology (free for a limited period)

Author Interview: Association of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults (free)

Commentary: Under 2017 Guideline, More Than 105 Million Americans Have Hypertension – AJMC (free)

The researchers estimated risk reductions of CVD and all-cause mortality, as well as associated harms from therapy, assuming the entire US adult population achieved guideline-recommended systolic BP treatment goals.

 

6 – Perspective: Ten dubious beliefs in neurocritical care – PulmCrit (free)

 

7 – A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill – Critical Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

 

8 – Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial – The Lancet (link to abstract – $ for full-text)

Related Article: Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial (link to abstract – $ for full-text)

Commentaries: Two Sham-Controlled Renal Denervation Studies Offer Hope in Hypertension – TCTMD (free) AND Renal denervation linked to significant drops in blood pressure – Cardiovascular Business (free) AND Novel Renal Denervation Catheters Showing Modest BP Reductions – MedPage Today (free registration required)

 

9 – Incidence and cost of medication harm in older adults following hospital discharge: A multicentre prospective study in the UK – British Journal of Clinical Pharmacy (free PDF)

Commentaries: Medication-related harm is common in older adults after hospital discharge – OnMedica (free) AND Medication-related harm found to be common among older adults, but preventable  – News Medical (free)

 

10 – Using alternatives to the car and risk of all-cause, cardiovascular and cancer mortality – Heart (free)

Commentaries: Avoiding the car for travel could significantly lower risk of illness and death – BMJ, via EurekAlert (free) AND Ditching the car may reduce your risk of dying from heart disease and stroke by almost a third – The Conversation (free)

 


 

1 – Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis – Critical Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

“In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced”.

 

2 – Aldosterone Antagonist Therapy and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Without Heart Failure: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Mineralocorticoid Receptor Antagonists in ST-Segment Elevation Myocardial Infarction – JAMA Internal Medicine (free for a limited period)

Aldosterone antagonists are beneficial for patients with STEMI and reduced ejection fraction. This meta-analysis suggests that patients with STEMI and LVEF greater than 40% or without heart failure also have improved outcomes with aldosterone antagonists.

 

3 – Effect of More vs Less Frequent Follow-up Testing on Overall and Colorectal Cancer–Specific Mortality in Patients With Stage II or III Colorectal Cancer: The COLOFOL Randomized Clinical Trial – JAMA (free for a limited period)

Related Trial: Association Between Intensity of Posttreatment Surveillance Testing and Detection of Recurrence in Patients With Colorectal Cancer (free for a limited period)

Commentaries: Surveillance intensity not associated with earlier detection of recurrence or improved survival in colorectal cancer – MedicalXpress (free) AND CRC: No Increase in Survival with Stepped-Up Surveillance – MedPage Today (free registration required) AND CRC recurrence surveillance studies: No benefit to high-intensity strategy – Oncology Practice (free)

 

4 – Efficacy and Safety of Dupilumab in Glucocorticoid-Dependent Severe Asthma – New England Journal of Medicine (free)

Related Article: Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma – New England Journal of Medicine (free)

Editorial: New Biologics for Asthma (free)

Commentary: Dupilumab Improves Severe Asthma – NEJM Physician’s First Watch (free)

 

5 – Five-Year Outcomes with PCI Guided by Fractional Flow Reserve – New England Journal of Medicine (free)

Commentary: FFR in PCI for Stable CAD: Lasting Benefit Shown by FAME 2, SCAAR Data – TCTMD (free)

 

6 – Pro/Con Debate: CTA as the Initial Test in Stable Angina – American College of Cardiology

Pro: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)

Con: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)

 

7 – How PrEP, the pill to prevent HIV, may be fueling a rise in other STDs – Vox (free)

Original Meta-Analysis: Effects of Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection on Sexual Risk Behavior in Men Who Have Sex With Men: A Systematic Review and Meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

See also: Guidelines on HIV Pre-exposure Prophylaxis (all free)

 

8 – Associations of egg consumption with cardiovascular disease in a cohort study of 0.5 million Chinese adults – Heart (free)

Commentaries: BMJ’s scrambled message on eggs and heart disease: a recipe for rotten news coverage – Health News Review (free) AND Expert reaction to eggs and CVD – Science Media Centre (free) AND No, Eating Eggs Will NOT Protect You From Cardiovascular Death – The Methods Man (free)

 

9 – Rapid Recommendations: Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline – The BMJ (free)

“We issue a strong recommendation for use of atraumatic needles in all patients (adults and children) undergoing lumbar puncture because they decrease complications and are no less likely to work than conventional needles”

 

10 – New BMJ Series: Universal Health Coverage

The BMJ in partnership with The Harvard Global Health Institute are launching a collection of articles that will explore how to achieve effective Universal Health Coverage (UHC)”

Analysis: Rethinking assumptions about delivery of healthcare: implications for universal health coverage (free)

Opinion: Non-communicable diseases must be part of Universal Health Coverage (free)

Opinion: Ensuring effective investments in Universal Health Coverage at the national level (free)

Opinion: Paying and investing in community health workers accelerates universal health coverage (free)

 


 

1 – Procalcitonin-Guided Use of Antibiotics for Lower Respiratory Tract Infection – New England Journal of Medicine (free)

Commentaries: Procalcitonin-Guided Care Doesn’t Reduce Antibiotics for Lower Respiratory Tract Infection – NEJM Journal Watch (free) AND Infection blood test of limited value in reducing antibiotic use – MedicalXpress (free)

 

2 – Joint statement from the American College of Surgeons Committee on Trauma (ACS COT) and the American College of Emergency Physicians (ACEP) regarding the clinical use of Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) (free)

Commentary: EMCrit Guest Post – The good, the bad, and the ugly of the Joint Statement on REBOA by Zaffer Qasim (free)

Source: Critical Care Reviews Newsletter

 

3 – Committee Opinion: Postpartum Pain Management – American College of Obstetricians and Gynecologists (free)

News Release: ACOG Recommends Postpartum Pain Management Approach Tailored to Patients (free)

Commentaries: ACOG: Postpartum Pain Management Requires Individualized Approach – MedPage Today (free registration required) AND OB/GYN Group Releases Guidance on Managing Postpartum Pain – NEJM Physician’s First Watch (free)

 

4 – WHO supports Ebola vaccination of high risk populations in the Democratic Republic of the Congo – World Health Organization (free)

Commentaries: Experimental Ebola Vaccinations, Considered ‘Paradigm Shift,’ Begin In Congo – NPR (free) AND Ebola vaccine drive launches in DRC as cases rise to 49 – CIDRAP (free) AND Congo begins giving experimental Ebola vaccine to medics – Reuters (free)

See also: Frequently asked questions on Ebola virus disease vaccine – World Health Organization (free)

“Health workers operating in affected areas in the Democratic Republic of the Congo are being vaccinated today and community outreach has started to prepare for the ring vaccination” (via @WHO see Tweet)

 

5 – Health care is an essential human right – and so is a proper diagnosis – The Conversation (free)

Related Commentary: For First Time, W.H.O. Names Some Lab Tests ‘Essential’ – The New York Times (10 articles per month are free)

See Original WHO Report: List of Essential In Vitro Diagnostics First edition (2018) – World Health Organization (free report and news release)

 

6 – Review: Autism spectrum disorder: advances in diagnosis and evaluation – The BMJ (free for a limited period)

 

7 – Opinion: Don’t Put That in My Heart Until You’re Sure It Really Works – The New York Times (10 articles per month are free)

Commentary: Cardiologist wants more rigorous testing before devices, techniques are adopted – Cardiovascular Business (free)

See also: Commentaries (PRO and Con) on the CABANA Trial (all free)

 

8 – Richard Lehman’s weekly journal review, 21 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Review: Identifying and managing depression in patients with coronary artery disease – Journal of the American Academy of Pas (free)

Commentaries: Depression in Patients With CAD – American College of Cardiology (free) AND Early Depression Diagnosis is Deadly Serious for Patients with Coronary Artery Disease – Florida State University, via NewsWise (free)

 

10 – Association of Burden of Atrial Fibrillation With Risk of Ischemic Stroke in Adults With Paroxysmal Atrial Fibrillation: The KP-RHYTHM Study – JAMA Cardiology (free)

Commentaries: Atrial Fibrillation Burden and Stroke Risk – American College of Cardiology (free) AND Greater burden of atrial fibrillation linked to higher stroke risk – Kaiser Permanente, via EurekAlert (free)

 


 

1 – Outbreaks Associated with Treated Recreational Water — United States, 2000–2014 – MMWR, CDC (free)

Commentaries: Hotel pools a factor in water-related illness outbreaks – CIDRAP (free) AND Crypto, Pseudomonas and Legionella responsible for most outbreaks in swimming venues – Outbreak News Today (free) AND Sparkling Pool Water May Hold Disease-Causing Parasites – The New York Times (10 articles per month are free) AND CDC: How To Avoid Getting Sick From A Hotel Swimming Pool – Forbes (free)

 

2 – May Measurement Month 2017: an analysis of blood pressure screening results worldwide – The Lancet Global Health (free)

Commentary: One in Three Have Hypertension – AJP (free)

What do we learn from checking blood pressure in >1.2 million people of 80 countries who have not had their BP measured in a year? 34% HTN, 46% not controlled, Saturday spikes and a lot more” (via @EricTopol see Tweet)

 

3 – Perspective: Trying to Put a Value on the Doctor-Patient Relationship – The New York Times Magazine (10 articles per month are free)

“In its push for profits, the U.S. health care system has made it difficult for patients to get personal attention from doctors. But what if hands-on medicine actually saves money — and lives?”

 

4 – E-cigarettes: A win or loss for public health? – Knowable Magazine (free)

Related Perspective: The Promise of Vaping and the Rise of Juul – The New Yorker (free)

See also: related guidelines, reports and commentaries on e-cigarettes (all free)

“Arguments over whether e-cigarettes are harmful or helpful seem gridlocked as emerging research underscores both the toxicity of vaping and its possible benefits”. (via @ghn_news see Tweet)

 

5 – Dose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized, Double-Blind Trials – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)

Commentary: Depression: boosting SSRIs doesn’t work – Univadis (free registration required)

“Meta-analysis: there is evidence from RCTs against increasing the dose of SSRIs (with the possible exception of citalopram) in adult patients with major depression and antidepressant treatment failure” (via @psychopharmacol see Tweet)

 

6 – Statement on the 1st meeting of the IHR Emergency Committee regarding the Ebola outbreak in 2018 – World Health Organization (free)

Commentaries: WHO: Ebola in DRC not global emergency; ring vaccination starts in 2 days – CIDRAP (free) AND Ebola outbreak is concerning, but falls short of global emergency, WHO panel says – STAT (free)

 

7 – Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients With Difficult Airways Undergoing Emergency Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: JC: Don’t blame it on the Bougie – St Emlyn’s (free) AND EM Nerd-The Peculiar Case of the Parallel Pathways – EmNerd (free) AND The humble bougie markedly boosts first-pass intubation success – Univadis (free registration required)

 

8 – Risk of suicide following an alcohol-related emergency hospital admission: An electronic cohort study of 2.8 million people – PLOS One (free)

Commentaries: Emergency hospital admissions for alcohol a red flag for suicide risk – new study – Public Health Wales (free) AND Alcohol-Related Emergency Admissions: A Marker for Suicide Risk – NEJM Journal Watch (free for a limited period)

 

9 – Report: World Health Statistics 2018: Monitoring health for the SDGs – World Health Organization (free)

Commentary: World Health Statistics: Over Half Of World’s Population Lack Essential Healthcare – WHO – Vigil 360 (free)

 

10 – Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease: A Science Advisory From the American Heart Association – Circulation (free PDF)

News Release: Keep saying yes to fish twice a week for heart health (free)

AHA News: Eating fish twice a week reduces heart, stroke risk (free)

Commentary: Omega-3 Fatty Acids and Coronary Heart Disease: A Very Fishy Story (free)

Top Ten Things to Know: Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease (free PDF)

 


 

1 – Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Inhaled Combined Therapy as Needed in Mild Asthma (free)

Related Trial: As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: International Study Suggests Alternative Treatment for Mild Asthma – McMaster University, via NewsWise (free) AND On Demand as Effective as Maintenance Therapy for Mild Asthma – Medscape (free registration required)

 

2 – Dementia And Physical Activity (DAPA) trial of moderate to high intensity exercise training for people with dementia: randomised controlled trial – The BMJ (free)

Commentaries: Exercise Doesn’t Slow Cognitive Decline in Patients with Dementia – NEJM Physician’s First Watch (free) AND Rigorous exercise does not halt dementia decline, study concludes – The Guardian (free) AND Expert reaction to effects of exercise on dementia in old people – Science Media Centre (free) AND Exercise ‘doesn’t slow’ progression of dementia – NHS Choices (free)

 

3 – WHO concerned as one Ebola case confirmed in urban area of Democratic Republic of the Congo – World Health Organization (free)

Commentaries: As Ebola hits major DRC city, WHO convenes emergency panel – CIDRAP (free) AND WHO to weigh declaration of international emergency over Ebola outbreak – STAT (free) AND Congo and WHO race to prevent runaway Ebola outbreak – Reuters (free) AND Fears of Larger Contagion as Ebola Spreads to Major Congo City  The New York Times (10 articles per month are free)

 

4 – Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank – The Lancet Psychiatry (link to abstract – for full-text)

Commentaries: Disrupted sleep-wake cycle linked to mental health problems – new study – The Conversation (free) AND Study: Body clock disruption linked to mood disorders – UPI (free) AND Body clock disruptions linked to mood disorders – NHS Choices (free) AND Maintaining a daily rhythm is important for mental health, study suggests – CNN (free)

 

5 – Psychological therapies for treatment-resistant depression in adults – Cochrane Library (free)

Summary: Are psychological therapies effective in treating depression that did not get better with previous treatment? – Cochrane Library (free)

 

6 – Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes – JAMA Neurology (free for a limited period)

Commentaries: Peripheral Neuropathy Common in Childhood Cancer Survivors – MPR (free) AND Chemo-Induced Neuropathy Common after Childhood Cancer – MedPage Today (free registration required)

 

7 – Opinion: The ten pitfalls of lactate clearance in sepsis – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

 

8 – Executive summary of the Clinical Guidelines of Pharmacotherapy for Neuropathic Pain: second edition by the Japanese Society of Pain Clinicians – Journal of Anesthesia (free)

 

9 – Adverse effects of statin therapy: perception vs. the evidence – focus on glucose homeostasis, cognitive, renal and hepatic function, haemorrhagic stroke and cataract – European Heart Journal (free)

Commentary: EAS Consensus Document Examines Safety of Statins Beyond Muscle Symptoms – TCTMD (free)

 

10 – Summary: The Practice of Cardio-Oncology in Spain: Position Statement From Scientific Societies Involved in Cancer and Heart Disease – American College of Cardiology (free)

Original Guideline: Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)

 


 

#ESOC2018 – Highlights from the 4th European Stroke Organization Conference

 

1 – #ESOC2018 – Tranexamic acid for hyperacute primary IntraCerebral Haemorrhage (TICH-2): an international randomised, placebo-controlled, phase 3 superiority trial – The Lancet (free)

Editorial: Haemostatic treatment for intracerebral haemorrhage (free)

Commentaries: Study: Drug to treat bleeding may reduce stroke deaths – UPI (free) AND Drug to treat bleeding may benefit some stroke patients, study finds – University of Nottingham, via EurekAlert (free)

 

2 – #ESOC2018 – Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (free)

Editorial: Antiplatelet Therapy after Ischemic Stroke or TIA (free)

Commentary: Dual Antiplatelet Therapy or Aspirin Alone After TIA or Minor Stroke? – NEJM Physician’s First Watch (free)

 

3 – #ESOC2018 – MRI-Guided Thrombolysis for Stroke with Unknown Time of Onset – New England Journal of Medicine (free)

Editorial: MRI-Guided Intravenous Alteplase for Stroke — Still Stuck in Time (free)

Commentary: New treatment option for ‘wake-up’ stroke patients – University of Glasgow, via MedicalXpress (free)

 

4 – #ESOC2018 – Rivaroxaban for Stroke Prevention after Embolic Stroke of Undetermined Source – New England Journal of Medicine (free)

Commentaries: NAVIGATE ESUS: Rivaroxaban Fails to Prevent More Recurrent Cryptogenic Strokes Than Aspirin – TCTMD (free) AND Rivaroxaban Not Superior to Aspirin for Patients with Embolic Stroke of Unknown Source – NEJM Physician’s First Watch (free)

 

5 – #ESOC2018 – Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke – New England Journal of Medicine (free)

Commentaries: Elevated Stroke Risk Continues for 5 Years After TIA – NEJM Physician’s First Watch (free) AND Five Years after TIA or Minor Stroke, Second-Event Risk Persists – MedPage Today (free)

 

6 – Manual: Managing epidemics: Key facts about major deadly diseases – World Health Organization (free)

“Managing epidemics. This @WHO manual provides concise, up-to-date knowledge on 15 infectious diseases that have the potential to become international threats, and tips on how to respond to each of them”. (via @Onisillos and @claireekt see Tweet)

 

7 – Report: Saving lives, spending less: a strategic response to noncommunicable diseases – World Health Organization (free PDF)

News Release: Investing in noncommunicable disease control generates major financial and health gains – World Health Organization (free)

“For every US$1 invested in each policy area, the following returns have been documented:

US$12.82 from promoting healthy diets

US$9.13 from reducing the harmful use of alcohol

US$7.43 from lower tobacco use

US$3.29 from providing drug therapy for cardiovascular disease

US$2.80 from increasing physical activity

US$2.74 from managing cancer”

 

8 – ASCO 2018: Shortening Adjuvant Trastuzumab to 6 Months in Patients With HER2-Positive Early Breast Cancer Is Effective and Reduces Cardiac Toxicities – The ASCO Post (free)

Commentaries: Test of Herceptin Finds Briefer Treatment Can Work, With Fewer Side Effects – NPR (free) AND Shorter drug treatment OK for many breast cancer patients – Associated Press (free) AND For Women With Early Breast Cancer, Herceptin Treatment Can Be Much Shorter – The New York Times (10 articles per month are free)

““For women with early-stage breast cancer who needed the drug Herceptin, 6 months of treatment were as good as 12, a major study found. Less risk of side effects, less cost, less time “being a patient.”” (via @NYTHealth see Tweet)

 

9 – Global Burden of Multiple Myeloma: A Systematic Analysis for the Global Burden of Disease Study 2016 – JAMA Oncology (free)

“Global incident cases of multiple myeloma more than doubled from 1990-2016 w/incident cases increasing by 126%. The largest increase was in middle-SDI countries, particularly E. Asia with a 262% increase in incidence cases”. (via @IHME_UW see Tweet)

 

10 – Ibuprofen versus pivmecillinam for uncomplicated urinary tract infection in women—A double-blind, randomized non-inferiority trial – PLOS Medicine (free)

Commentary: Ibuprofen alone not an option for simple UTIs, study finds – CIDRAP (free) AND Randomized trial finds ibuprofen not a safe alternative to antibiotics for UTIs – PLOS, via ScienceDaily (free)

Related Research: Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)

 


 

1 – News Release: First-ever WHO list of essential diagnostic tests to improve diagnosis and treatment outcomes (free) (via @Onisillos)

Executive summary: List of Essential In Vitro Diagnostics, First edition (2018) – World Health Organization (free PDF)

 

2 – Report: The Characteristics of Pandemic Pathogens: Improving Pandemic Preparedness by Identifying the Attributes of Microorganisms Most Likely to Cause a Global Catastrophic Biological Event – Johns Hopkins Bloomberg School of Public Health (free PDF)

News release: Study by center for health security identifies characteristics of microorganisms most likely to cause a global pandemic (free)

Commentaries: Is this the face of Disease X? The deadly pathogens which could cause the next global pandemic – The Telegraph (free) AND The Next Deadly Pandemic Could Be Unlike Any Threats We Know, Say Experts – Science Alert (free) AND The Next Pandemic: Forget Zika Or Ebola, Airborne Viruses Like The Flu And The Common Cold Are The Real Threat – Inquisitr (free) AND Report: Next Pandemic Will Likely Be Respiratory-Based Virus – MedPage Today (free registration required)

Related: Are we prepared for the looming epidemic threat? (free commentaries and video)

 

3 – Position Paper: Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories – Obesity Reviews (free)

Commentary: Some calories more harmful than others – University of California, via EurekAlert (free)

 

4 – Review: Diagnostic workup, etiologies and management of acute right ventricle failure – Intensive Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

 

5 – Improving Prediction of Dementia in Primary Care – Annals of Family Medicine (free)

Commentaries: Screening Tool Improves Dementia Prediction – Medscape (free registration required) AND Visual Test Could Help Predict Dementia Risk in Elders – NEJM Physician’s First Watch (free)

 

6 – Use of Flutemetamol F 18–Labeled Positron Emission Tomography and Other Biomarkers to Assess Risk of Clinical Progression in Patients With Amnestic Mild Cognitive Impairment – JAMA Neurology (free)

Commentaries: Biomarkers, PET imaging may predict cognitive decline en route to Alzheimer’s – Health Imaging (free) AND Amyloid PET Scan Can Predict Progression to Alzheimer’s in Patients With Mild Cognitive Impairment – MedicalResearch.com (free)

Related Studies: Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons (link to abstract and free commentaries) AND Identifying incipient dementia individuals using machine learning and amyloid imaging (free full-text and commentaries) AND High performance plasma amyloid-β biomarkers for Alzheimer’s disease (link to abstract and free commentaries)

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: April 2018 – eCancer News (free)

 

8 – Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non–Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Intravesical Gemcitabine Therapy Cuts Bladder Cancer Recurrence – MPR (free) AND Simple post-surgery step reduces bladder cancer recurrence – SWOG, via EurekAlert (free)

 

9 – Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Outcomes similar with DES vs. BMS in saphenous vein graft lesions – Healio (free registration required)

 

10 – Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence – JAMA (free for a limited period)

Related Reviews: Optimizing post‐polypectomy surveillance: A practical guide for the endoscopist – Digestive Endoscopy (free) AND Optimal Colonoscopy Surveillance Interval after Polypectomy – Clinical Endoscopy (free)

Related Guidelines: Guidelines for Colonoscopy Surveillance After Screening and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer (free) AND Korean Guidelines for Postpolypectomy Colonoscopy Surveillance – Digestive Endoscopy (free) AND Colorectal cancer surveillance after index colonoscopy: Guidance from the Canadian Association of Gastroenterology (free) AND Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline (free)

Advanced adenomas are associated with subsequent increased risk for colorectal cancer, but nonadvanced adenomas don’t seem to be associated with increased risk.

 


 

1 – News Release: WHO plan to eliminate industrially-produced trans-fatty acids from global food supply – World Health Organization (free)

See also: REPLACE Action package: Trans Fat Free by 2023 – World Health Organization (free resources)

Commentaries: Editorial Board Opinion: The World Doesn’t Need Trans Fats – The New York Times (10 articles per month are free) AND WHO calls for trans fats to be eliminated within five years – Reuters (free) AND Industrial trans fats must be removed from food supply, WHO says – The Guardian (free) AND The new global plan to eliminate the most harmful fat in food, explained – VOX (free)

 

2 – Experimental vaccine to be used against Ebola outbreak in the DRC – STAT (free)

Related: WHO to send vaccines to fight new Ebola outbreak – NBC News (free) AND The New Ebola Outbreak Could Take ‘Three, Maybe Four’ Months to Control – The Atlantic (free)

See also: WHO News: Ebola Outbreak Declared in Democratic Republic of the Congo (free news release and commentaries)

 

3 – Complete Revascularization During Primary Percutaneous Coronary Intervention Reduces Death and Myocardial Infarction in Patients With Multivessel Disease: Meta-Analysis and Meta-Regression of Randomized Trials – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

Commentary: Complete Revascularization During PCI for Multivessel STEMI – American College of Cardiology (free)

Related: Meta-Analysis of Culprit-Only vs Multivessel PCI in Patients with STEMI and Multivessel Coronary Disease (link to abstract, commentaries and Cochrane Review on the subject)

 

4 – The Burnout Crisis in American Medicine – The Atlantic (free)

Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free) AND To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians – New England Journal of Medicine (free)

 

5 – Richard Lehman’s journal review, 14 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

6 – Perspective: Deployment of Preventive Interventions — Time for a Paradigm Shift – New England Journal of Medicine (free)

 

7 – Headline vs. study: Sometimes fishy, sometimes pulling a rabbit out of a hat – Health News Review (free)

 

8 – Guideline: Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free) (via @Deprescribing)

Related: CaDeN Deprescribing Guidelines and Algorithms (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)

 

9 – NAP6 Report: Anaesthesia, Surgery and Life-Threatening Allergic Reactions: Report and findings of the Royal College of Anaesthetists’ 6th National Audit Project (free PDF)

News Release: RCoA undertakes largest ever study of anaphylaxis in anaesthesia and surgery (free)

Infographic: Anaesthesia, Surgery and Life-Threatening Allergic Reactions (free PDF)

“The study found teicoplanin is 17-fold more likely to cause anaphylaxis than penicillin and similar drugs. As 90 per cent of patients who report penicillin allergy are in fact not allergic, better identification of true allergy would reduce risk”. (from News Release)

 

10 – Guideline: Screening for impaired vision in community-dwelling adults aged 65 years and older in primary care settings – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers (free)

Commentaries: Screening for impaired vision in older adults: New Canadian guideline – Canadian Medical Association Journal, via EurekAlert (free) AND Canadian Guideline Recommends Against Vision Screening of Older Adults in Primary Care Settings – NEJM Physician’s First Watch (free)

 


 

1 – Restrictive versus Liberal Fluid Therapy for Major Abdominal Surgery – New England Journal of Medicine (free)

Editorial: Finding the Right Balance (free)

Commentaries: Restrictive fluids tied to kidney injury after major abdominal surgery – MDedge (free) AND Restricting Fluids During Abdominal Surgery Shows No Benefit, Possible Renal Risk – Medscape (free registration required)

 

2 – Investigational Testing for Zika Virus among U.S. Blood Donors – New England Journal of Medicine (free)

Quick Take Video Summary: Testing Blood Donations for Zika Virus (free)

Sounding Board: Revisiting Blood Safety Practices Given Emerging Data about Zika Virus (free)

Commentaries: Study: Zika blood donation screening costly, finds few cases – CIDRAP (free) AND Testing for Zika virus in blood donors finds few infections — at a cost of about $5.3 million each – STAT (free)

 

3 – Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo—a Meta-analysis of Individual Data – Gastroenterology (link to abstract – $ for full-text)

Commentary: Severe alcoholic hepatitis: corticosteroids alone are best for short-term survival – Univadis (free registration required)

 

4 – Advice for Patients: Are blood pressure measurement mistakes making you chronically ill? – American Heart Association News (free text and infographic)

Commentary: BP measurement: you’re probably doing it wrong – Univadis (free registration required)

 

5 – Oral Antibiotic Exposure and Kidney Stone Disease – Journal of the American Society of Nephrology (link to abstract – $ for full-text)

Commentaries: Study suggests oral antibiotics may increase kidney stone risk – CIDRAP (free) AND Antibiotics May Raise the Risk for Kidney Stones – The New York Times (free) AND Oral Antibiotics May Raise Risk of Kidney Stones – Children’s Hospital of Philadelphia, via NewsWise (free)

 

6 – Viewpoint: Management Reasoning: Beyond the Diagnosis – JAMA (free for a limited Period)

 

7 – Association of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Resistance Exercise Might Improve Depression Symptoms – NEJM Physician’s First Watch (free) AND Resistance exercise may reduce depressive symptoms in adults – MedicalXpress (free) AND Resistance Exercise Training May Alleviate Some Depressive Symptoms – MedicalResearch.com (free)

 

8 – Global statistics on alcohol, tobacco and illicit drug use: 2017 status report – Addiction (free PDF)

Commentaries: Alcohol and tobacco are by far the biggest threat to human welfare of all addictive drugs – Society for the Study of Addiction, via ScienceDaily (free) AND Which drugs pose the biggest threat to public health? – Medical News Today (free)

 

9 – Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of adverse events in non-randomised studies – Cochrane Library (link to abstract – $ for full-text)

Summary: Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of harmful effects – Cochrane Library (free)

“Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate”.

 

10 – Cost-effectiveness of Electroconvulsive Therapy vs Pharmacotherapy/Psychotherapy for Treatment-Resistant Depression in the United States – JAMA Psychiatry (free for a limited period)

Author interview: Cost-effectiveness of Electroconvulsive Therapy for Treatment-Resistant Depression in the United States (free)

Commentaries: Study about ‘shock therapy’ for depression suggests more patients should try it sooner – Michigan Medicine – University of Michigan, via EurekAlert (free) AND Third-Line Electroconvulsive Therapy May Be Best for Patients With Treatment-Resistant Depression – Psychiatric News Alert (free) AND ECT Found Cost Effective Early in Depression Treatment – MedPage Today (free registration required)

 


 

1 – AHA/ACOG Presidential Advisory: Promoting Risk Identification and Reduction of Cardiovascular Disease in Women Through Collaboration with Obstetricians and Gynecologists – Circulation (free PDF)

News Releases: OB-GYNs, cardiologists join to fight the No. 1 killer of women (free) AND Annual well woman visit to the OB/GYN can keep your heart healthy: AHA/ACOG Presidential Advisory (free)

Top Ten Things to Know: Promoting Risk Identification and Reduction of Cardiovascular Disease in Women Through Collaboration with Obstetricians and Gynecologists (free PDF)

 

2 – Vertebroplasty versus sham procedure for painful acute osteoporotic vertebral compression fractures (VERTOS IV): randomised sham controlled clinical trial – The BMJ (free)

Editorial: No more vertebroplasty for acute vertebral compression fractures? (free)

Related Systematic Review: Percutaneous vertebroplasty for osteoporotic vertebral compression fracture – Cochrane Library (link to abstract and summary)

 

3 – CABANA: No Outcomes Benefit In First Big Trial Of AF Ablation – Cardiobrief (free)

Related Commentaries: Catheter ABlation vs ANtiarrhythmic Drug Therapy in Atrial Fibrillation – CABANA – American College of Cardiology (free) AND CABANA Misses Primary Endpoint, but Electrophysiologists See Support for Ablation – TCTMD (free)

 

4 – Guideline: Erectile Dysfunction – American Urology Association (2018) (free)

 

5 – EULAR recommendations for the health professional’s approach to pain management in inflammatory arthritis and osteoarthritis – Annals of Rheumatic Diseases (free)

Commentary: EULAR Releases Recommendations for Pain Management in OA, Inflammatory Arthritis – Rheumatology Advisor (free)

 

6 – Perspective: The Catch-22 of Mass-Prescribing Antibiotics – Wired (free)

Related Commentary: African study on pre-emptive antibiotics in kids spurs resistance debate – CIDRAP (free)

Related Study: Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa – New England Journal of Medicine (free)

 

7 – Mode of delivery after a previous cesarean birth, and associated maternal and neonatal morbidity – Canadian Medical Association Journal (free)

Commentary: Higher risks associated with vaginal birth after cesarean, although absolute risk small – CMAJ, via ScienceDaily (free)

 

8 – New Online Course: An introduction to systematic searching in PubMed – University of Nottingham (free)

“This course shows you how you can construct a comprehensive, systematic search strategy in PubMed to answer a clinical question” (via @CochraneUK see Tweet)

 

9 – Systematic Review: Induction of labour for improving birth outcomes for women at or beyond term – Cochrane Library (free)

Summary: Induction of labour in women with normal pregnancies at or beyond term – Cochrane Library (free)

 

10 – Risk of stroke and transient ischaemic attack in patients with a diagnosis of resolved atrial fibrillation: retrospective cohort studies – The BMJ (free)

Commentaries: Tom Marshall: The importance of asking the right research question – BMJ Opinion (free) AND Patients who have had an irregular heart beat can’t ever be considered ‘cured’ – University of Birmingham (free)

 


 

1 – Accelerate progress—sexual and reproductive health and rights for all: report of the Guttmacher–Lancet Commission – The Lancet (free)

News Release: Guttmacher-Lancet Commission Proposes a Bold, New Agenda for Sexual and Reproductive Health and Rights – Guttmacher Institute (free)

Executive Summary: Accelerate Progress: Sexual and Reproductive Health and Rights for All – Guttmacher Institute (free)

Invited commentaries: Sexual and reproductive health and rights for all: an urgent need to change the narrative (free) AND Addressing the unfinished agenda on sexual and reproductive health and rights in the SDG era (free) AND Defining sexual and reproductive health and rights for all (free)

Commentaries: Why it could cost less than R120 per year to save a life – Bhekisisa (free) AND Gender-based violence must be at the heart of global health agenda: expert comment – London School of Hygiene & Tropical Medicine (free)

 

2 – Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors – Cochrane Library (link to abstract and summary – $ for full-text)

News Release: Does HPV vaccination prevent the development of cervical cancer? Are there harms associated with being vaccinated? – Cochrane Library (free)

Scientific Expert Reaction: Cochrane Review on HPV vaccine for cervical cancer prevention in girls and women – Cochrane Library (free)

Commentaries: HPV vaccine ‘safe and effective’, says review – NHS Choices (free) AND Experts welcome new evidence on HPV jab efficacy and safety – OnMedica (free)

  

3 – High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD): A Randomized Superiority Trial – Circulation (free)

With a median follow-up of 3.9 years, high-dose as compared with low-dose pitavastatin significantly reduced the risk of the primary end point (4.3% vs 5.4%; NNT = 90), a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, or unstable angina requiring emergency hospitalization.

 

4 – Implications for paediatric shock management in resource-limited settings: a perspective from the FEAST trial – Critical Care (free)

Original article: Mortality after Fluid Bolus in African Children with Severe Infection – New England Journal of Medicine (free)

 

5 – Call for public comments on the draft WHO Guidelines: Saturated fatty acid and trans-fatty intake for adults and children – World Health Organization (free)

Commentaries: Eat less saturated, trans fats to curb heart disease: WHO – Reuters (free) AND Eat Less Saturated and Trans Fats, World Health Organization Says – Consumer Reports (free) AND ‘Bad’ fats targeted in new global health guidelines – UN News (free)

“Adults and children should consume a maximum of 10 percent of their daily calories in the form of saturated fat such as meat and butter and one percent from trans fats to reduce the risk of heart disease, the World Health Organization said on Friday” (from Reuters)

 

6 – Effect of post-discharge virtual wards on improving outcomes in heart failure and non-heart failure populations: A systematic review and meta-analysis – PLOS One (free)

Commentary: Hospital-to-home transitional care reduces deaths, readmissions for heart failure – Cardiovascular Business (free)

 

7 – Correction to: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association – Stroke (free PDF)

Commentaries: AHA Rescinds Large Sections of New Stroke Guidelines – Medscape (free registration required) AND AHA/ASA retracts large portion of new stroke guidelines – Cardiovascular Business (free)

 

8 – Editorial: All science should inform policy and regulation – PLOS Medicine (free) (via @RasoiniR)

 

9 – Association of Preprocedural Fasting With Outcomes of Emergency Department Sedation in Children – JAMA Pediatrics (free for a limited period)

Commentaries: Preprocedural Fasting Not Necessary for Children in ED – Medscape (free registration required) AND Pre-Sedation Guidelines for Kids May Be Too Strict – MedPage Today (free registration required)

Related: NPO for sedation? Don’t swallow the myth – First10Em (free)

 

10 – Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Author Interview: Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults (free)

Commentaries: Psychological interventions can help treat chronic pain in seniors – UPI (free) AND Not All In Your Head: Psychological Therapies Not a Panacea for Pain – MedicalResearch.com (free)

 


 

1 – Hypertension Canada’s 2018 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults and Children – Canadian Journal of Cardiology (free)

 

2 – Hypertension Canada’s 2018 Guidelines for the Management of Hypertension in Pregnancy – Canadian Journal of Cardiology (free)

 

3 – Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Prostate-Specific Antigen (PSA) Screening for Prostate Cancer: Revisiting the Evidence (free) AND USPTF Prostate Cancer Screening Recommendations—A Step in the Right Direction (free) AND Implications of the New USPSTF Prostate Cancer Screening Recommendation—Attaining Equipoise (free) AND Prostate Cancer Screening—A New Recommendation for Meaningful Physician-Patient Conversations (free)

Author Interview: USPSTF Recommendation: Screening for Prostate Cancer (free)

Video Summary: PSA Screening for Prostate Cancer: The 2018 USPSTF Recommendation Statement (free)

Infographic with key Facts: Is Prostate Cancer Screening Right for You? Understanding the Potential Benefits vs. Harms for Men 55-69 (free)

Commentary: Prostate cancer screening: the decision is up to you – Reuters (free)

 

4 – Effect of Coaching to Increase Water Intake on Kidney Function Decline in Adults With Chronic Kidney Disease: The CKD WIT Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: Drinking more water does not slow decline of kidney function for kidney disease patients – Lawson Health Research Institute, via EurekAlert (free) AND Study: Drinking more water doesn’t slow kidney disease – UPI (free)

 

5 – Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans – JAMA Neurology (free for a limited period)

Editorial: Risk of Dementia Outcomes Associated With Traumatic Brain Injury During Military Service (free)

Commentaries: Dementia Risk Doubles Following Concussion, UCSF Study Shows – University of California San Francisco (free) AND Vets with Head Injury More Likely To Develop Dementia – MedicalResearch.com (free)

See two recent cohort studies with similar results: Long-term risk of dementia among people with traumatic brain injury (link to abstract and free commentaries) AND Traumatic Brain Injury and the Risk of Dementia Diagnosis (free article and commentaries)

 

6 – New Ebola outbreak declared in Democratic Republic of the Congo – World Health Organization (free)

Commentaries: New Ebola outbreak confirmed in DR Congo: UN health agency scales up response – UN News (free) AND Seventeen deaths reported in Congo as Ebola outbreak confirmed – Reuters (free) AND DRC confirms 2 Ebola infections, probes suspected cases – CIDRAP (free)

 

7 – Guideline: Investigation and management of a raised serum ferritin – British Journal of Haematology (free)

 

8 – Richard Lehman’s journal review, 8 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Alzheimer’s? Your Paperwork May Not Be in Order – The New York Times (10 articles per month are free)

Related: New Document for Patients: Advanced Health Directive for Dementia (free document and commentaries)

 

10 – Platelet Count Affects Efficacy of Folic Acid in Preventing First Stroke – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Folic acid ‘may help reduce stroke risk in people with high blood pressure’ – NHS Choices (free) AND Folic Acid Supplements May Reduce Stroke Risk in Hypertensive Patients – American College of Cardiology (free) AND Folic Acid Cut Strokes in Hypertensive Patients on Enalapril – MedPage Today (free registration required) AND Folic acid supplementation may help prevent first stroke in high-risk patients with hypertension – ACP Internist (free)

 


 

1 – Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet – Pediatrics (free)

Commentaries: How Low Can You Go? Does Lower Carb Translate to Lower Glucose? – Pediatrics (free) AND Very-low-carb diet shows promise in type 1 diabetes – Boston Children’s Hospital, via ScienceDaily (free) AND How a Low-Carb Diet Might Aid People With Type 1 Diabetes – The New York Times (10 articles per month are free) AND Is Exceptional Control of Type 1 Diabetes Possible with a Low-Carbohydrate Diet? – Dr. David Ludwig Blog (free)

*Randomized controlled trials are warranted.

 

2 – Clinical Oncology Society of Australia position statement on exercise in cancer care – The Medical Journal of Australia (free)

Commentaries: Every cancer patient should be prescribed exercise medicine – The Conversation (free) AND Cancer: ‘If exercise was a pill it would be prescribed to every patient’ – The Guardian (free)

 

3 – Guideline: Management of stable angina – Scottish Intercollegiate Guidelines Network (free)

 

4 – Guideline: Pharmacological management of migraine – Scottish Intercollegiate Guidelines Network (free)

 

5 – The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)

Opinion Against this Guideline: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free) (via @emdocsdotnet)

 

6 – Review: Alternatives to the Swan–Ganz catheter – Intensive Care Medicine (free for a limited period) (via @f_g_zampieri)

 

7 – Perspective: Questionable Admissions – New England Journal of Medicine (free)

 

8 – Clinical Handbook: Care of girls and women living with female genital mutilation – World Health Organization (free)

 

9 – Summary: AHA Scientific Statement on Right Heart Failure – American College of Cardiology (free)

Original Guideline: Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association (free PDF)

 

10 – Type 2 diabetes mellitus and heart failure: a position statement from the Heart Failure Association of the European Society of Cardiology – European Journal of Heat Failure (free)

 


 

1 – SAVE LIVES: Clean Your Hands, 5 May 2018 – World Health Organization Campaign (free guidelines, implementation tools, infographics, videos and more)

“It’s in your hands – prevent sepsis in health care”

 

2 – Consensus statement for cancer patients requiring intensive care support – Annals of Hematology (free)

Source: Critical Care Reviews Newsletter

 

3 – Comprehensive in‐hospital monitoring in acute heart failure: applications for clinical practice and future directions for research. A statement from the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) – European Journal of Heart Failure (free)

Source: Critical Care Reviews Newsletter

 

4 – A Simple Way to Improve a Billion Lives: Eyeglasses – The New York Times (10 articles per month are free)

“It’s the biggest health crisis you’ve never heard of. Doctors, philanthropists and companies are trying to solve it”.

 

5 – Opinion: Can we say who has died because of the breast-screening appointment error? – by David Spiegelhalter (free) (via @RichardLehman1 and @d_spiegel, see Tweet with infographic)

Related opinions: Breast cancer screening scandal must prompt review of mammograms – The Guardian (free) AND Breast cancer screening programme ‘does more harm than good’ – BBC (free) AND Did Breast Cancer Screening Error Cause Major Health Harm? – Medscape (free registration required)

 

6 – Decisions, Decisions: HMS physicians review the many factors in choosing breast cancer screenings – Harvard Medical School (free commentary and video) (via @tlisboa79 and @brhospitalist)

Original article: Breast Cancer Screening in 2018: Time for Shared Decision Making – JAMA (link to abstract – $ for full-text)

 

7 – Don’t confuse “no evidence of a difference” with “evidence of no difference” – Students 4 Best Evidence (free)

 

8 – University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free)

Related: Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

 

9 – Pre-pregnancy fast food and fruit intake is associated with time to pregnancy – Human Reproduction (free)

Commentary: Women who eat fast food may take longer to get pregnant – NHS Choices (free) AND Women Who Eat Fast Food Take Longer to Become Pregnant – University of Adelaide, via NewsWise (free) AND Want to increase fertility? Try dropping fast food – CNN (free)

 

10 – Sauna bathing reduces the risk of stroke in Finnish men and women: A prospective cohort study – Neurology (link to abstract – $ for full-text)

Commentaries: Daily saunas may reduce stroke risk – NHS Choices (free) AND Can Saunas Lower Stroke Risk? – MedPage Today (free registration required) AND Could saunas reduce stroke risk? – Medical News Today (free)

 


 

1 – Manual: Core Components for Infection Prevention and Control: Implementation tools and resources – World Health Organization (free) (via @julesstorr and @Onisillos)

 

2 – Outpatient Infection Prevention: A Practical Primer – Open Forum Infectious Diseases (free) (via @IDSAInfo see Tweet)

Commentary: Pioneering Paper Shows Infection Control and Prevention in Clinics Is in Everyone’s Hands – University of Texas Health Science Center at Houston, via NewsWise (free)

 

3 – Emollient bath additives for the treatment of childhood eczema (BATHE): multicentre pragmatic parallel group randomised controlled trial of clinical and cost effectiveness – The BMJ (free)

Editorial: New evidence challenges use of bath emollients for children with eczema (free)

Commentaries: Trial finds no benefit of bath emollients beyond standard eczema care for children – The BMJ, via ScienceDaily (free) AND Bath oils for childhood eczema provide ‘no clinical benefit’ – NHS Choices (free)

 

4 – Education plus exercise versus corticosteroid injection use versus a wait and see approach on global outcome and pain from gluteal tendinopathy: prospective, single blinded, randomised clinical trial – The BMJ (free)

Commentary: The ongoing reduction in pain became the inspiration to never go back to “ground zero” – The BMJ Opinion (free)

 

5 – Plastic Surgery’s Contributions to Surgical Ethics – AMA Journal of Ethics (free)

“Important for plastic surgeons in particular to remember: just because you *can* perform an operation, which might or might not be medically indicated, does not mean you *should* perform the operation” (via @JournalofEthics see Tweet)

 

6 – Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Single-Inhaler Triple Therapy in Patients with COPD (free)

 

7 – Lecture: How Less Health Care Can (Sometimes) Be Better For You (free)

See also: CLUE Working Group Lecture Series (tweet with lecture links by @KariTikkinen)

“Editor-in-Chief of @JAMAInternalMed, professor Rita Redberg gave the 3rd CLUE Working Group lecture entitled “How Less Health Care Can (Sometimes) Be Better For You” at the Think Corner of the U of Helsinki” (via @KariTikkinen see Tweet)

 

8 – 2017 European guideline for the screening, prevention and initial management of hepatitis B and C infections in sexual health settings – International Journal of STD & AIDS (free PDF)

 

9 – Direct oral anticoagulant (DOAC) versus low-molecular-weight heparin (LMWH) for treatment of cancer associated thrombosis (CAT): A systematic review and meta-analysis – Thrombosis Research (free)

Source: EvidenceAlerts

 

10 – Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression – JAMA Psychiatry (free for a limited period)

Commentaries: With Early Intervention, Patients With Schizophrenia Experience Greater Improvements in Health, Function – Psychiatric News Alert (free) AND Early Intervention Best for Early-Phase Psychosis – MedPage Today (free registration required)

 


 

1 – 9 out of 10 people worldwide breathe polluted air, but more countries are taking action – World Health Organization (free)

Related Infographics: PHE Infographics: Air pollution (free)

Updated Fact Sheets: Ambient (outdoor) air quality and health (free) AND Household air pollution and health (free)

Commentaries: Air pollution inequality widens between rich and poor nations – The Guardian (free) AND Expert reaction to new WHO global air pollution data – Science Media Centre (free)

 

2 – 2018 ACC/HRS/NASCI/SCAI/SCCT Expert Consensus Document on Optimal Use of Ionizing Radiation in Cardiovascular Imaging: Best Practices for Safety and Effectiveness (Free)

Commentary: New Expert Consensus Document Provides Best Practices For Ionizing Radiation Safety – American College of Cardiology (free)

 

3 – Long-Term Effects of Omitting Antibiotics in Uncomplicated Acute Diverticulitis – American Journal of Gastroenterology (link to abstract – $ for full-text)

Commentary: Uncomplicated acute diverticulitis: omitting antibiotics found safe in DIABOLO – Univadis (free registration required)

 

4 – Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: Glyburide Should Not Be First-Line for Gestational Diabetes – Medscape (free registration required) AND Glyburide Compared With Insulin for First-Line Tx of Gestational Diabetes – MPR (free)

 

5 – Clinical Practice Guideline: Chronic Asthma – Toward Optimized Practice (free PDF)

See also: Summary (free PDF)

Related: see all TOP Clinical Practice Guidelines, a practical resource for Family Physicians at the point of care.

 

6 – Viewpoint: In the Era of Precision Medicine and Big Data, Who Is Normal? – JAMA (free for a limited period)

 

7 – Dietary intake and age at natural menopause: results from the UK Women’s Cohort Study – Journal of Epidemiology & Community Health (free)

Commentaries: Diet rich in fish and legumes may help to delay natural menopause – BMJ, via EurekAlert (free) AND Expert reaction to study looking at dietary intake and age at menopause – Science Media Centre (free) AND Oily fish and fresh beans may be linked to a later menopause – NHS Choices (free)

 

8 – Interventions for preventing occupational irritant hand dermatitis – Cochrane Library (link to abstract – $ for full-text)

Summary: Treatments to prevent hand skin irritation in the workplace – Cochrane Library (free)

 

9 – Indications for the Performance of Intracranial Endovascular Neurointerventional Procedures: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Key Points to Remember: Indications for Intracranial Endovascular Procedures – American College of Cardiology (free)

 

10 – Preventability of Early Versus Late Hospital Readmissions in a National Cohort of General Medicine Patients – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Hospital care quality more likely a factor in early versus late readmissions – ACP Hospitalist (free) AND Hospital readmissions occurring within 7 days post-discharge may be more preventable than later readmissions – 2 Minute Medicine (free)

 


 

1 – Pre-operative evaluation of adults undergoing elective noncardiac surgery: Updated guideline from the European Society of Anaesthesiology (free)

 

2 – Support for midlife anxiety diagnosis as an independent risk factor for dementia: a systematic review – BMJ Open (free)

Commentaries: Moderate to severe mid-life anxiety may be linked to later life dementia – BMJ Open Blog (free) AND Anxiety in middle age linked to dementia later – Reuters (free) AND Expert reaction to a review of the association between mid-life anxiety and later life dementia – Science Media Centre (free)

“The current study isn’t designed to explain how anxiety and dementia might be connected, Iadecola added. “We cannot say with confidence that anxiety is a cause (risk factor), an early manifestation of the dementia, or only coincidentally associated with it,”” (from Reuters)

 

3 – Report: Trends in Reported Vectorborne Disease Cases — United States and Territories, 2004–2016 – MMWR, CDC (free)

Commentaries: CDC reports tripling of vector-borne diseases since 2004 – CIDRAP (free) And Tick and Mosquito Infections Spreading Rapidly, C.D.C. Finds – The New York Times (10 articles per month are free) AND Tick- and mosquito-borne diseases more than triple, since 2004, in the US – CNN (free)

 

4 – Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Three-Minute Brain Stimulation Sessions Effectively Reduce Depression Symptoms, Study Finds – Forbes (free) AND Three Minute Version of Brain Stimulation Therapy Effective for Hard to Treat Depression – Neuroscience News (free)

 

5 – Nonpharmacologic and Medication Minimization Strategies for the Prevention and Treatment of ICU Delirium: A Narrative Review – Journal of Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

 

6 – Systematic Reviews & Meta-Analyses: A 5-Step Checkup – Absolutely Maybe in PLOS Blogs (free)

 

7 – Prospective study on the incidence, prevalence and 5-year pancreatic-related mortality of pancreatic cysts in a population-based study – Gut (free)

Commentary: Incidental Pancreatic Cysts: Majority Don’t Progress to Cancer – Medscape (free registration required)

 

8 – Cardiopulmonary Resuscitation in Infants and Children With Cardiac Disease: A Scientific Statement From the American Heart Association – Circulation (free PDF)

News release: New guidance issued for treating cardiac arrest in children with heart disease (free)

Top Ten Things to Know: Cardiopulmonary Resuscitation in Infants and Children with Cardiac Disease (free PDF)

 

9 – Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Commentary: ASCO Clinical Practice Guideline Update: Fertility Preservation in Patients With Cancer – The ASCO Post (free)

Related guidelines: Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines – Clinical and Experimental Reproductive Medicine (free) AND Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline – Human Fertility (free)

 

10 – USPSTF Draft Recommendation Statement: Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: Screening (free)

Commentaries: USPSTF urges abuse screening for reproductive-aged women – MedicalXpress (free) AND USPSTF Recommends Screening for Partner Violence in Reproductive-Aged Women – Clinical Advisor (free)

“The USPSTF recommends that clinicians screen for intimate partner violence (IPV) in women of reproductive age and provide or refer women who screen positive to ongoing support services.”

 


 

1 – Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population – Circulation (free PDF)

Commentaries: Five healthy habits may add more than a decade to life – Circulation Journal Report (free) AND The five habits that can add more than a decade to your life – The Guardian (free) AND Following five healthy lifestyle habits may increase life expectancy by decade or more – Harvard T.H. Chan School of Public Health, via ScienceDaily (free)

 

2 – Meta-Analysis: Radial-Artery or Saphenous-Vein Grafts in Coronary-Artery Bypass Surgery – New England Journal of Medicine (free for a limited period)

Commentaries: More Data Show Benefits of Multiple Arterial Over Saphenous-Vein Grafting in CABG: Meta-analysis – TCTMD (free) AND Radial Artery or Saphenous Vein Grafts in CABG – American College of Cardiology (free)

 

3 – Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Stroke: Which Clot Buster Drug Works Best? – MedicalResearch.com (free) AND Tenecteplase Appears Superior to Alteplase After Ischemic Stroke – Cardiology Advisor (free)

 

4 – Report: Using Technology to Advance Global Health – National Academies of Sciences, Engineering, and Medicine. 2018 (free PDF, registration required)

 

5 – Are sweet snacks more sensitive to price increases than sugar-sweetened beverages: analysis of British food purchase data – BMJ Open (free)

Commentaries: Taxing sweet snacks may bring even greater health benefits than taxing sugar-sweetened drinks – London School of Hygiene & Tropical Medicine (free) AND Soda Tax Backers Eye Cookies and Candy – MedPage Today (free)

Related: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND To improve global health, tax the things that are killing us (free articles, commentaries and reports) AND The Lancet taskforce on NCDs and economics (free series and commentaries)

 “A 10% tax would reduce the purchase of chocolates and other candy by 7.4%, of cookies by 6.9%, and of cake-type snacks by 6.6%” (via @medpagetoday see Tweet)

 

6 – Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Regular exercise may help lower your risk of depression – NHS Choices (free) AND Regular Exercise Lowers Odds of Developing Depression, Meta-Analysis Finds – Psychiatric News Alert (free)

 

7 – Report: Using dietary intake modelling to achieve population salt reduction – A guide to developing a country-specific salt reduction model (2018) – WHO Europe (free PDF)

“The Salt Reduction Model is a 5-step plan to help countries achieve a 30% reduction in population salt intake. Reducing salt consumption will help prevent and control noncommunicable diseases such as heart disease and stroke” (via @WHO_Europe see Tweet)

 

8 – Richard Lehman’s journal review, 30 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Economics of Palliative Care for Hospitalized Adults With Serious Illness: A Meta-analysis – JAMA Internal Medicine (free for a limited period)

Commentaries: Study: Palliative Care Reduces Hospital Stay, Cost of Sickest Patients – U.S. News (free) AND Prompt Palliative Care Saves Money, Especially in Sickest Patients – MedPage Today (free registration required)

 

10 – Exploring the Role of Infographics for Summarizing Medical Literature – Health Professions Education (free)

“Are #infographic / #visualabstract summaries of literature preferred to abstracts? Do they decrease cognitive load? Do they increase retention? Check out our latest!” (via @Brent_Thoma see Tweet and Visual Abstract)

 


 

1 – Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentary: Too liberal use of oxygen increases risk of death in acutely ill adult patients – McMaster University, via EurekAlert (free)

 

2 – Development and validation of a Hospital Frailty Risk Score focusing on older people in acute care settings using electronic hospital records: an observational study – The Lancet (free)

Commentaries: What proportion of older adults in hospital are frail? – The Lancet (free) AND Research helps frail older people in hospitals – University of Leicester, via EurekAlert (free)

 

3 – Universal health care, worldwide, is within reach – The Economist (a few articles per month are free)

Source: International Health Policies Newsletter

 

4 – Guide to Improving Patient Safety in Primary Care Settings by Engaging Patients and Families – Agency for Healthcare Research and Quality (free PDF)

See also: About the Guide (free) AND Infographic (free PDF) AND Quick Start Guide (free)

 

5 – Expert statement for the management of hypovolemia in sepsis – Intensive Care Medicine (free for a limited period)

Source: Critical Care Reviews Newsletter

 

6 – Asia-Pacific working group consensus on non-variceal upper gastrointestinal bleeding: an update 2018 – Gut (free)

Source: Critical Care Reviews Newsletter

 

7 – Improving Emergency Department Care for Low-Risk Chest Pain – NEJM Catalyst (free)

 

8 – Debate: Should we recommend e-cigarettes to help smokers quit? – The BMJ (free)

See also: related guidelines, reports and commentaries on e-cigarettes

“Experts debate: Should doctors recommend e-cigarettes to help smokers quit? Revelation in harm reduction or a way to keep people addicted and gateway to youth smoking?” (via @rich_hurley see Tweet)

 

9 – 28th ECCMID: The MERINO Trial: piperacillin-tazobactam versus meropenem for the definitive treatment of bloodstream infections caused by third-generation cephalosporin nonsusceptible Escherichia coli or Klebsiella spp.: an international multi-centre openlabel non-inferiority randomised controlled trial (free abstract)

Commentaries: Avoid piperacillin-tazobactam when treating BSI cause by ceftriaxone-resistant pathogens – European Society of Clinical Microbiology and Infectious Diseases, via EurekAlert (free) AND Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free)

 

10 – Predictors of post-stroke fever and infections: a systematic review and meta-analysis – BMC Neurology (free)

Commentary: Predictors of poststroke pneumonia clarified – Univadis (free)

 


 

1 – Microbial Preparations (Probiotics) for the Prevention of Clostridium difficile: Infection in Adults and Children: An Individual Patient Data Meta-analysis of 6,851 Participants – Infection Control & Hospital Epidemiology (free)

Commentary: Probiotics may be safe, low-cost prevention tool for Clostridium difficile infections – News Medical (free)

Related Articles: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use – Cochrane Library (free) AND Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free) AND Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)

 

2 – Anticholinergic drugs and risk of dementia: case-control study – The BMJ (free)

Editorial: Anticholinergic drugs and dementia in older adults (free)

Commentaries: Expert reaction to study investigating the association between different types of anticholinergic drugs and risk of dementia – Science Media Centre (free) AND Anticholinergic drugs may be linked to increased risk of dementia – OnMedica (free)

“The effect of anticholinergic therapy is relatively small (odds ratio 1.1 – 1.2) and establishing an association does not prove a causal link. Nevertheless, the paper may act as a useful guide for future research and clinical practice”. (by Prof Les Iversen, in Science Media Centre)

 

3 – Age and sex of surgeons and mortality of older surgical patients: observational study – The BMJ (free)

Editorial: Links between age and sex of surgeons and patients’ outcomes (free)

Commentary: Study Suggests Older Surgeons Produce Lower Mortality Rates in Emergency Procedures – UCLA, via NewsWise (free)

 

4 – Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis – Cochrane Library (free for a limited period)

News Release: Featured Review: Uterotonic agents for preventing postpartum haemorrhage – Cochrane Library (free)

Commentary: Review finds more effective drugs to stop bleeding after childbirth – University of Birmingham (free)

New Cochrane Review suggests ergometrine plus oxytocin; misoprostol plus oxytocin; & carbetocin on its own, are more effective drugs for reducing excessive bleeding at childbirth rather than the current standard use of oxytocin on its own” (via @CochraneUK see Tweet)

 

5 – Optimised care of elderly patients with acute coronary syndrome – European Heart Journal: Acute Cardiovascular Care (free) (via @krychtiukmd see Tweet)

 

6 – Perspective: The Mediterranean Diet’s Fight Against Frailty – JAMA (free for a limited period)

 

7 – Committee Opinion: Adolescents and Long-Acting Reversible Contraception: Implants and Intrauterine Devices – American College of Obstetrics and Gynecology (free)

Commentary: ACOG Committee Opinion: adolescents should be offered LARC – Univadis (free registration required)

 

8 – Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines. Update April 2018 – Journal of Virus Eradication (free)

Related guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)

 

9 – Being patient with EBM. “Just because we can, doesn’t mean we should” – supporting informed decision-making – Evidently Cochrane Blog (free)

 

10 – NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure – Circulation (link to abstract – $ for full-text)

Related Systematic Review: Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model – Health Technology Assessment (free) AND Commentary: Uncertain benefits of BNP blood tests to monitor heart failure treatment – NIHR Signal (free)

Related AHA Scientific Statement: Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure (free)

Source:  EvidenceAlerts

“NT Pro BNP guided heart failure treatment no better than usual care”. (via @doctorvec)

 


 

1 – World Malaria Day, 25 April 2018 – World Health Organization (free resources)

 

2 – Effect of generalised access to early diagnosis and treatment and targeted mass drug administration on Plasmodium falciparum malaria in Eastern Myanmar: an observational study of a regional elimination programme – The Lancet (free)

Commentaries: Can improving access to care help to eliminate malaria? – The Lancet (free) AND Dose entire population with anti-malaria drugs to eradicate disease – study – The Guardian (free) AND Malaria studies show benefit of mass treatment, methylene blue – CIDRAP (free)

Related: Seminar: Malaria (free registration required) AND Series: Malaria in Pregnancy (free registration required)

 

3 – Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa – New England Journal of Medicine (free)

Quick Take Video Summary: Azithromycin to Reduce Childhood Mortality (free)

Commentaries: Giving Antibiotics To Healthy Kids In Poor Countries: Good Idea Or Bad Idea? – NPR (free) AND Infant Deaths Fall Sharply in Africa With Routine Antibiotics – The New York Times (free)

 

4 – Guideline: Pharmacologic Glycemic Management of Type 2 Diabetes in Adults – Canadian Journal of Diabetes (free)

Related Guidelines: ADA 2018 Standards of Medical Care in Diabetes (free) AND ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes (free)

In this new guideline Hemoglobin A1c Targets are similar from ADA 2018 Standards.

 

5 – Polypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) (via @trishgreenhalgh)

Related Reviews: Current and future perspectives on the management of polypharmacy – BMC Family Medicine (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free)

 

6 – Incorporating medication indications into the prescribing process – American Journal of Health-System Pharmacy (free)

Source: Hospital Medicine Virtual Journal Club (free)

 

7 – Guideline Update: Depression in adults: recognition and management – National Institute for Health and Care Excellence (free)

 

8 – Things We Do For No Reason: Periprocedural Bridging Anticoagulation – Journal of Hospital Medicine (free)

 

9 – A cancer drug tailored to your tumor? Experts trade barbs over ‘precision oncology’ – Science (free)

See also: Audio and slides on the meeting webcast (free) (via @barttels2 and @AACRPres see Tweet)

 

10 – Physicians’ Compassion, Communication Skills, and Professionalism With and Without Physicians’ Use of an Examination Room Computer: A Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)

Commentaries: Patients Prefer Doctors Who Engage in Face-to-Face Visits – Physician’s Briefing (free) AND Docs Behind Screen Seen as Less Compassionate – MedPage Today (free registration required) AND Patients value eye contact from physicians: study – Univadis (free registration required)

 


 

1 – A Randomized Trial of Early Endovenous Ablation in Venous Ulceration – New England Journal of Medicine (free)

Commentary: Early treatment for leg ulcers gets patients back on their feet – Imperial College London (free)

 

2 – Committee Opinion: Optimizing Postpartum Care – American College of Obstetricians and Gynecologists (free)

Commentary: Redesigning Maternal Care: OB-GYNs Are Urged to See New Mothers Sooner and More Often – ProPublica (free)

Source: Kaiser Health News Morning Brief

 

3 – Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Sigmoidoscopy reduces colon cancer risk for men, but not women – American College of Physicians, via MedicalXpress (free) AND Sigmoidoscopy reduces colon cancer risk for men, but not women – 2 Minute Medicine (free)

 

4 – Heading Frequency Is More Strongly Related to Cognitive Performance Than Unintentional Head Impacts in Amateur Soccer Players – Frontiers in Neurology (free)

Commentary: Soccer Heading—Not Collisions—Cognitively Impairs Players – Albert Einstein College of Medicine (free)

Related Review: Effects of Soccer Heading on Brain Structure and Function – Frontiers in Neurology (free)

 

5 – Teaching Computers to “See” the Invisible in Living Cells – NIH Director’s Blog (free)

Original Study: In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images (free) AND Commentary: Scientists teach computers how to analyze brain cells – NIH News Release (free)

 

6 – Pasta Is Good For You, Say Scientists Funded By Big Pasta – BuzzFeed News (free)

 

7 – Domain Management Approach to Heart Failure in the Geriatric Patient: Present and Future – Journal of the American College of Cardiology (free for a limited period) (via @monicaAGrinberg)

 

8 – Viewpoint: David Oliver: Tube feeding and deteriorating patients—guidelines can take us only so far – The BMJ (free)

Related Guidelines: American Geriatrics Society Feeding Tubes in Advanced Dementia Position Statement (free) AND ESPEN guideline on ethical aspects of artificial nutrition and hydration (free)

Related Reviews: Artificial nutrition and hydration in advanced dementia – Canadian Family Physician (free) AND End-of-life issues in advanced dementia: Part 1: goals of care, decision-making process, and family education – Canadian Family Physician (free) AND End-of-life issues in advanced dementia: Part 2: management of poor nutritional intake, dehydration, and pneumonia – Canadian Family Physician (free) AND Advanced Dementia – New England Journal of Medicine (free)

 

9 – Prenatal Exposure to Acetaminophen and Risk for Attention Deficit Hyperactivity Disorder and Autistic Spectrum Disorder: A Systematic Review, Meta-Analysis, and Meta-Regression Analysis of Cohort Studies – American Journal of Epidemiology (free)

Commentary: Prolonged acetaminophen use during pregnancy linked to increased ASD and ADHD risk – The Hebrew University of Jerusalem, via EurekAlert (free)

 

10 – Maternal caffeine intake during pregnancy and childhood growth and overweight: results from a large Norwegian prospective observational cohort study – BMJ Open (free)

Commentaries: Fetal exposure to moderate/high caffeine levels linked to excess childhood weight gain – BMJ Open Blog (free) AND Caffeine in pregnancy linked to risk of child overweight – OnMedica (free) AND Expert reaction to study looking at caffeine in pregnancy and weight gain in children – Science Media Centre (free)

 


 

1 – World Immunization Week, 24-30 April 2018 – World Health Organization (free resources)

 

2 – The vaccine dilemma: how experts weigh benefits for many against risks for a few – STAT (free)

 

3 – Why do we need vaccines? – Welcome Trust (free) (via @greg_folkers)

 

4 – Exercise after a heart attack — it could save your life, research suggests – European Society of Cardiology, via ScienceDaily (free)

Other commentaries: Regular exercise after heart attack might halve risk of death over next few years – OnMedica (free) AND It’s not too late: Exercise after heart attack cuts mortality risk – Cardiovascular Business (free) AND Remaining Active After MI May Help Stave Off Mortality – TCTMD (free)

“Becoming more physically active after a myocardial infarction halves the risk of dying within 4 years, study finds”

 

5 – Safety and efficacy of dual vs. triple antithrombotic therapy in patients with atrial fibrillation following percutaneous coronary intervention: a systematic review and meta-analysis of randomized clinical trials – European Heart Journal (free)

“Compared with triple antithrombotic therapy, dual antithrombotic therapy shows a reduction in major or minor bleeding by 47% with comparable outcomes of major adverse cardiac events”.

 

6 – Practice guideline recommendations summary: Disease-modifying therapies for adults with multiple sclerosis – Neurology (free)

See also: Related Physician Tools and Materials (free clinician summary, slides and more)

Commentaries: New guideline: Start taking MS drugs early on – American Academy of Neurology, via EurekAlert (free) AND New MS Guideline Addresses Starting, Switching, and Stopping Disease-modifying Therapy – MD Magazine (free) AND Start MS Drugs Early, New Guideline Says – MedPage Today (free registration required)

 

7 – Guidelines for the Use of Antiretroviral Agents in Adults and Adolescents Living with HIV – AIDSInfo (free)

 

8 – Richard Lehman’s journal review, 23 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – State of the Art Review: Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications – The BMJ (free for a limited period)

 

10 – Proton‐Pump Inhibitors and Long‐Term Risk of Community‐Acquired Pneumonia in Older Adults – Journal of the American Geriatrics Society (free)

Commentary: Commonly prescribed heartburn drug linked to Pneumonia in Older Adults – University of Exeter (free)

Related: Proton Pump Inhibitors: Review of Emerging Concerns – Mayo Clinic Proceedings (free) AND Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free) AND Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)

Source: Hospital Medicine Virtual Journal Club

 


 

1 – Report: WHO Expert Consultation on Rabies – World Health Organization (free)

News release: WHO publishes new rabies guidelines and recommendations on lifesaving immunization (free)

 

2 – Simplifying the use of prognostic information in traumatic brain injury – Journal of Neurosurgery

Part 1: The GCS-Pupils score: an extended index of clinical severity (free)

Part 2: Graphical presentation of probabilities (free)

Commentaries: New Glasgow Coma Scale–Pupils Score and Multifactor Probability Outcome Charts for Use in Patients with TBI – Journal of Neurosurgery, via NewsWise (free) AND New scoring system will speed up assessment of brain injuries – OnMedica (free) AND Glasgow Coma Scale Gets an Eye-Opening Update – Medscape (free registration required)

 

3 – Revised SAGE recommendation on use of dengue vaccine – World Health Organization (free)

Commentaries: A new dengue vaccine should only be used in people who were previously infected, WHO says – Science (free) AND WHO recommends testing before use of Sanofi’s dengue vaccine – Reuters (free)

 

4 – Headache Classification Committee of the International Headache Society (IHS) The International Classification of Headache Disorders, 3rd edition – Cephalalgia (free PDF) (via @adamcifu)

News release and website: The International Classification of Headache Disorders 3rd edition (free)

Commentary: International Classification of Headache Disorders – The Lancet Neurology (free)

 

5 – Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder – Bipolar Disorders (free)

Related Guideline: Bipolar disorder: assessment and management – National Institute for Health and Care Excellence (free)

 

6 – Diagnosis and Management of Primary Aldosteronism: the Endocrine Society guideline 2016 revisited – European Journal of Endocrinology (free)

 

7 – Review: Hypokalemia: a clinical update – Endocrine Connections (free)

 

8 – Role of Immunotherapy in the Treatment of Asthma – Agency for Healthcare Research and Quality (free)

Source: EvidenceAlerts

 

9 – Effect of 5-Day Nitrofurantoin vs Single-Dose Fosfomycin on Clinical Resolution of Uncomplicated Lower Urinary Tract Infection in Women: A Randomized Clinical Trial – JAMA (free)

Editorial: Nitrofurantoin vs Fosfomycin: Rendering a Verdict in a Trial of Acute Uncomplicated Cystitis – JAMA (free)

 

10 – Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Intranasal Esketamine Found Effective in Rapid Reduction of Depression, Suicidal Thoughts – Psychiatric News Alert (free) AND Fast-acting benefits of ketamine for depression and suicidality – American Psychiatric Association, via ScienceDaily (free) AND Ketamine ‘shows promise’ in treating depression – OnMedica (free) AND Ketamine Spray Effective for Suicidality, but Abuse Concerns Linger – Medscape (free registration required)

Related: ‘Cautious Optimism’ Marks Outlook for Ketamine, Mood Disorders – Psychiatric News (free)

 


 

1 – The “Top 12” Recommendations That Are Reducing Overuse – Choosing Wisely (free) (via @kennylinafp)

Learn more on the Choosing Wisely Initiative and see other lists of low-value practices in Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

2 – Choosing Wisely Campaigns: A Work in Progress – JAMA (free for a limited period) (via @ChooseWiselyCA  see Tweet)

 

3 – Association of Repeated Measurements With Blood Pressure Control in Primary Care – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Repeat BP Measurements in the Office Are Key, Study Highlights – TCTMD (free) AND Should Blood Pressure Measurement Be Repeated During Primary Care Visit? – MedicalResearch.com (free) AND Second BP Measurement Often Brings Better News – MedPage Today (free registration required) AND Repeated BP Measures Linked to Drop in Initially Elevated BP – Physician’s Weekly (free)

 

4 – Prospective International Randomized Phase II Study of Low-Dose Abiraterone With Food Versus Standard Dose Abiraterone In Castration-Resistant Prostate Cancer – Journal of Clinical Oncology (free)

Commentaries: Taking a Standard Prostate Cancer Drug with Food Boosts Impact, Lowers Cost – University of Chicago Medical Center, via NewsWise (free) AND Low-Dose Prostate Drug Can Match Standard Dose, Cut Costs – Medscape (free registration required)

Related: Tackling the High Cost of Cancer Care (free commentaries issued when this paper was first presented at the 2017 ASCO annual meeting)

“Savings per patient could reach as high as $300,000” (from NewsWise)

 

5 – Cancer treatment in the last 6 months of life: when inaction can outperform action – eCancer Medical Science (free)

 

6 – Debate on systematic reviews and meta-analyses: (via @trished)

Viewpoint 1: Are systematic reviews and meta-analyses still useful research? We are not sure – Intensive Care Medicine (free)

Viewpoint 2: Are systematic reviews and meta-analyses still useful research? Yes (free)

 

7 – Recommended Standard Care for People with Suicide Risk: Making Health Care Suicide Safe – National Action Alliance for Suicide Prevention (free PDF)

News Release: New Recommended Standard Care for People with Suicide Risk Aims to Fundamentally Improve Suicide Care Delivered Nationwide (free PDF)

Commentary: First-Ever Suicide Prevention Recommendations Released – Medscape (free registration required)

 

8 – Report: Multimorbidity: a priority for global health research – The Academy of Medical Sciences (free) (via @equitylist)

News Release: Global burden of multiple serious illnesses must be urgently addressed (free)

Commentaries: Burden of patients with multiple diseases could sink health systems around the world, warn medical experts – Independent (free) AND People with multiple health conditions get raw deal, says report – OnMedica (free)

See also: related articles on the Caring for High-Need, High-Cost Patients (free reports, articles and commentaries)

 

9 – Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Marijuana’s effects on young brains diminish 72 hours after use, research says – CNN (free) AND ‘Poorer Cognitive Functioning’ of Marijuana Users Detailed in New Study – Inverse (free)

 

10 – British HIV Association Standards of care for people living with HIV 2018 (free)

Commentary: New care standards for HIV aim to boost quality despite funding pressures – OnMedica (free)

 


 

1 – Relationship between Clinic and Ambulatory Blood-Pressure Measurements and Mortality – New England Journal of Medicine (free)

Editorial: The Value in an Ambulatory Blood-Pressure Registry (free)

Commentaries: Value of Ambulatory BP Monitoring Bolstered by Large Study – TCTMD (free) AND 24-hour ambulatory BP measurements strongly predict mortality – The Hospitalist (free) AND Expert reaction to study looking at blood pressure measurement method and predicting risk of heart disease – Science Media Centre (free)

 

2 – Gene Therapy in Patients with Transfusion-Dependent β-Thalassemia – New England Journal of Medicine (free)

Editorial: Gene Therapy as a Curative Option for β-Thalassemia (free)

Quick Take Video Summary: LentiGlobin Gene Therapy for β-Thalassemia (free)

Commentaries: Gene therapy could free some people from a lifetime of blood transfusions – MIT Technology Review (free) AND Gene Therapy For Inherited Blood Disorder Reduced Transfusions – NPR (free) AND Expert reaction to study on gene therapy for beta-thalassaemia – Science Media Centre (free)

 

3 – A randomized trial of normothermic preservation in liver transplantation – Nature (free PDF for a limited period)

Commentaries: Room temperature liver storage technique improves transplant success – University of Oxford (free) AND Keeping livers ‘alive’ boosts transplant success, trial finds – BBC (free) AND A ‘breakthrough in organ preservation’: Study shows keeping livers warm helps preserve them for transplant – STAT (free)

 

4 – Viewpoint: Another Nail in the Coffin for Fish Oil Supplements – JAMA (free for a limited period)

 

5 – Time to challenge the spurious hierarchy of systematic over narrative reviews? – European Journal of Clinical Investigation (free) (via @kennylinafp and @Abraham_RMI)

 

6 – Artificial pancreas treatment for outpatients with type 1 diabetes: systematic review and meta-analysis – The BMJ (free)

Editorial: Closed loop systems in type 1 diabetes (free for a limited period)

 

7 – First-line drugs for hypertension – Cochrane Library (free)

Summary: Thiazides best first choice for hypertension – Cochrane Library (free)

 “First-line low-dose thiazides reduced all morbidity and mortality outcomes in adult patients with moderate to severe primary hypertension. First-line ACE inhibitors and calcium channel blockers may be similarly effective, but the evidence was of lower quality”.

 

8 – Transradial versus transfemoral approach for diagnostic coronary angiography and percutaneous coronary intervention in people with coronary artery disease – Cochrane Library (link to abstract – $ for full-text)

Summary: Radial artery versus femoral artery approach for performing coronary catheter procedures in people with coronary artery disease – Cochrane Library (free)

“Transradial approach for diagnostic coronary angiography or PCI (or both) in CAD may reduce short-term net adverse clinical events, cardiac death, all-cause mortality, bleeding, and access site complications”.

 

9 – British Thoracic Society Quality Standards for acute non-invasive ventilation in adults – BMJ Open Respiratory Research (free)

Related Guidelines: Clinical practice guidelines for the use of noninvasive positive-pressure ventilation and noninvasive continuous positive airway pressure in the acute care setting – Canadian Medical Association Journal (free) AND BTS/ICS guideline for the ventilatory management of acute hypercapnic respiratory failure in adults – Thorax (free)

Source: Critical Care Reviews Newsletter

 

10 – Association Between Baseline LDL-C Level and Total and Cardiovascular Mortality After LDL-C Lowering: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Patients With Highest LDL Levels Benefit Most From Lipid-Lowering Drugs – MedicalResearch.com (free) AND New Study Finds that Statins Prevent Cardiovascular Deaths – Science Based Medicine (free) AND Meta-Analysis: ‘Floor’ for Lipid-Lowering Mortality Benefits May Be Real – MedPage Today (free registration required)

“In meta-analyses of LDL-C lowering drug trials, we found that total and cardiovascular mortality were reduced only when the mean baseline LDL-C in the trial was >100 mg/dl” (from MedicalResearch.com)

  


 

1 – Interventions to Prevent Falls in Community-Dwelling Older Adults: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Preventing Fractures and Falls: A Limited Role for Calcium and Vitamin D Supplements? (free) AND New Prevention Guidelines for Falls and Fractures—Looking Beyond the Letters (free)

Author Interview: USPSTF Recommendation: Calcium and Vitamin D to Prevent Fractures and Interventions to Prevent Falls in Community-Dwelling Adults (free)

Commentaries: Exercise, not vitamins, urged to prevent falls in seniors – MedicalXpress (free) AND Older adults may not need vitamin D to prevent falls and fractures – Reuters (free)

“Many older adults should avoid taking vitamin D and calcium supplements to prevent falls and fractures, and focus instead on exercises to improve balance and coordination, U.S. doctors recommend” (from Reuters)

 

2 – Association Between Use of Sodium-Glucose Cotransporter 2 Inhibitors, Glucagon-like Peptide 1 Agonists, and Dipeptidyl Peptidase 4 Inhibitors With All-Cause Mortality in Patients With Type 2 Diabetes – JAMA (free)

Multimedia (2 minute video): Association Between Newer Antidiabetic Drug Classes and Mortality in Patients With Type 2 Diabetes (free)

Commentary: Diabetes drug may not reduce risk of death – Imperial College London (free)

 

3 – State of Global Air 2018 (free report and interactive website)

Commentaries: Over 7 Billion People Face Unsafe Air: State of Global Air 2018 – Institute for Health Metrics and Evaluation (free) AND More than 95% of world’s population breathe dangerous air, major study finds – The Guardian (free) AND More than 95% of world’s population breathing unhealthy air, says new report – CNN (free)

 

4 – Opinion: The Case Against Thrombolytic Therapy in Stroke – By John Mandrola, in Medscape (free registration required)

Related: For Many Strokes, There’s an Effective Treatment. Why Aren’t Some Doctors Offering It? – The New York Times (10 articles per month are free)

 

5 – Incremental Benefits and Harms of the 2017 American College of Cardiology/American Heart Association High Blood Pressure Guideline – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: New blood pressure guidelines may make millions anxious that they’re at risk of heart disease – The Conversation (free) AND New blood pressure guidelines could put lives at risk – The University of Sydney (free)

Related: AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free) AND The Hypertension Guideline War Is Not A Fake War – Cardiobrief (free) AND Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free)

 

6 – Nut consumption and incidence of seven cardiovascular diseases – Heart (free)

Commentary: Nuts May Be Good for the Heart, but Are Hardly a Miracle Food – The New York Times (10 articles per month are free)

 

7 – Clinical Guideline Synopsis: Management of Ventricular Arrhythmias and Sudden Cardiac Death Risk Related to Ischemic and Nonischemic Cardiomyopathy – JAMA (free for a limited period)

Original Guideline: 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death – Circulation (free PDF)

 

8 – Exercise interventions and patient beliefs for people with hip, knee or hip and knee osteoarthritis: a mixed methods review – Cochrane Library (free)

 

9 – Smoking even one cigarette a day raises risk for coronary heart disease – The Washington Post (a few articles per month are free) (via @DrFrieden see Tweet)

See original article: Meta-Analysis: Just One Cigarette a Day Seriously Elevates Cardiovascular Risk (free article and commentaries)

 

10 – Cardiovascular and Cerebrovascular Emergency Department Visits Associated With Wildfire Smoke Exposure in California in 2015 – Journal of the American Heart Association (free for a limited period)

Commentaries: Air quality linked to cardiac ‘events,’ heart disease patients unaware – Reuters (free) AND Wildfire smoke associated with more ER visits for heart, stroke ailments among seniors – American Heart Association, via ScienceDaily (free)

 


 

1 – Addressing Social Determinants to Improve Patient Care and Promote Health Equity: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

 

2 – Guidelines for the investigation of chronic diarrhoea in adults: British Society of Gastroenterology, 3rd edition – Gut (free)

Source: Hospital Medicine Virtual Journal Club

 

3 – Atrial Fibrillation Burden: Moving Beyond Atrial Fibrillation as a Binary Entity: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentary: Atrial Fibrillation beyond “All or None”: The Missing Piece in Understanding Atrial Fibrillation? (free)

Top Ten Things to Know: Atrial Fibrillation Burden—Moving Beyond AF as a Binary Entity (free PDF)

 

4 – Pembrolizumab plus Chemotherapy in Metastatic Non–Small-Cell Lung Cancer – New England Journal of Medicine (free)

Commentaries: AACR 2018: Combination therapy doubles survival in metastatic lung cancer – eCancer News (free) AND Lung Cancer Patients Live Longer With Immune Therapy – New York Times (10 articles per month are free)

 

5 – Associations between chronotype, morbidity and mortality in the UK Biobank cohort – Chronobiology International (free)

Commentaries: ‘Night owls’ slightly more likely to die sooner than ‘early birds’ – NHS Choices (free) AND Why being a night owl may lead to earlier death – VOX (free) AND Night Owls Could Face Higher Risk Of Premature Death, Study Suggests – Forbes (free)

 

6 – Acid‐suppressive drugs and risk of kidney disease: A systematic review and meta‐analysis – Journal of Gastroenterology and Hepatology (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club

Proton pump inhibitors were associated with higher risks of acute interstitial nephritis (HR, 2.78; 95% CI, 1.25‐6.17), acute kidney injury (HR, 1.85; 95% CI, 1.33‐2.59), chronic kidney disease (HR, 1.47; 95% CI, 1.03‐2.09), and end‐stage renal disease (HR, 1.61; 95% CI, 1.26‐2.04) than non‐PPI therapy. Similar risks were not identified for H2RA therapy.

 

7 – Global burden of mental disorders among children aged 5–14 years – Child and Adolescent Psychiatry and Mental Health (free)

Commentary: Mental disorders among leading causes of illness in children worldwide – BioMed Central, via ScienceDaily (free)

 

8 – Richard Lehman’s journal review, 16 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – New Series from The Lancet Journals: Preconception health (free registration required)

Commentaries: Obese couples could be risking health of future children, studies say – The Guardian (free) AND Parents’ Preconception Well-Being Affects Child’s Future Health – Medscape (free registration required)

 

10 – The Risk of Fatigue and Sleepiness in the Ridesharing Industry: An American Academy of Sleep Medicine Position Statement – Journal of Clinical Sleep Medicine (free)

Commentary: AASM: Ridesharing Industry Needs to Do More to Promote Safety – MPR (free)

 


 

1 – Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies – The Lancet (free)

Editorial: Thresholds for safer alcohol use might need lowering (free)

Commentaries: Drinking a pint of beer may lower your life expectancy by the same amount as smoking a cigarette – new research – The Conversation (free) AND Expert reaction to study looking at drinking alcohol, life expectancy and alcohol limits – Science Media Centre (free) AND More than six weekly glasses of wine could curb life expectancy by up to five years – OnMedica (free) AND Consuming more than five drinks a week could shorten your life – University of Cambridge, via ScienceDaily (free) AND How much alcohol is too much? A new study says it’s found the number – PBS News Hour (free)

 

2 – Short-term Elevation of Fine Particulate Matter Air Pollution and Acute Lower Respiratory Infection – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentaries: Brief SExposure to Tiny Air Pollution Particles Triggers Childhood Lung Infections – Intermountain Medical Center, via NewsWise (free) AND Spikes in air pollution can heighten risk of chest infections, research suggests – The Guardian (free) AND Air Pollution May Pose Serious Risks to Young Children – The New York Times (10 articles per month are free) AND Short-Term Pollution Spikes Trigger Lung Infections in Young Kids – MedPage Today (free registration required)

 

3 – Primary care of adults with intellectual and developmental disabilities: 2018 Canadian consensus guidelines – Canadian Family Physician (free)

Related guideline: Care and support of people growing older with learning disabilities – National Institute for Health and Care Excellence (free)

 

4 – New affordable hepatitis C combination treatment shows 97 percent cure rate – Drugs for Neglected Diseases Initiative, via EurekAlert (free)

Related: Non-profit’s $300 hepatitis C cure as effective as $84,000 alternative – The Guardian (free) AND Hepatitis C: simplified curative treatments can drive global scale-up – World Health Organization (free)

 

5 – Association of Survival With Adherence to the American Cancer Society Nutrition and Physical Activity Guidelines for Cancer Survivors After Colon Cancer Diagnosis: The CALGB 89803/Alliance Trial – JAMA Oncology (free for a limited period)

Editorial: Helping Colorectal Cancer Survivors Benefit From Changing Lifestyle Behaviors: Implementation Science and Private Industry Collaboration to the Rescue (free for a limited period)

Commentaries: Colon Cancer Patients Who Follow a Healthy Lifestyle Have Longer Survival – NEJM Physician’s First Watch (free) AND Adherence to ACS Guidelines Linked to Survival in Colon Cancer – Physician’s Briefing (free)

 

6 – Sedentary behavior associated with reduced medial temporal lobe thickness in middle-aged and older adults – PLOS One (free)

Commentaries: Sitting Is Bad for Your Brain – Not Just Your Metabolism or Heart – University of California – Los Angeles, via NewsWise (free) AND Could Too Much Sitting Possibly Make Your Brain Thinner? – Forbes (free)

 

7 – n−3 Fatty Acid Supplementation for the Treatment of Dry Eye Disease – New England Journal of Medicine (free for a limited period)

Commentaries: Omega-3s From Fish Oil Supplements No Better Than Placebo for Dry Eye – NIH, National Eye Institute (NEI), via NewsWise (free) AND Fish oil capsules don’t help dry eye symptoms, study finds – STAT (free) AND Fish oil supplements ineffective against dry eye – Reuters (free)

 

8 – The Clinical Trial Is Open. The Elderly Need Not Apply – The New York Times (10 articles per month are free)

Related: Cardiac Patients in Trials Don’t Reflect Real-World Populations (link to abstract and commentaries on the subject)

“There’s a shocking lack of data on effective treatments for older people. So what do doctors do? Make guesses”. (via @NYTHealth see Tweet)

 

9 – Gallstones: Watch and wait, or intervene? – Cleveland Clinic Journal of Medicine (free)

“Consider laparoscopic cholecystectomy for symptomatic cholelithiasis, expectant management for asymptomatic cases”.

 

10 – Effectiveness of a long-lasting piperonyl butoxide-treated insecticidal net and indoor residual spray interventions, separately and together, against malaria transmitted by pyrethroid-resistant mosquitoes: a cluster, randomised controlled, two-by-two factorial design trial – The Lancet (free)

Commentaries: Insecticide-resistant malaria vectors must be tackled – The Lancet (free) AND Advanced insecticidal nets protect against malaria, study shows – CIDRAP News Scan for Apr 12, 2018 (free) AND ‘Resistance breaking’ mosquito net provides children with greater protection against malaria – London School of Hygiene & Tropical Medicine (free)

“The novel net nearly halves malaria infection rate in Tanzanian children compared to standard long-lasting pyrethroid nets” (from London School of Hygiene & Tropical Medicine)

 


 

1 – Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentary: Taking the Good With the Bad – Assigning Value and Blame to the Right Heart in Cardiovascular Disease (free)

Top Ten Things to Know: Evaluation and Management of Right-Sided Heart Failure (free PDF)

 

2 – Protecting, promoting, and supporting breastfeeding in facilities providing maternity and newborn services: the revised Baby-friendly Hospital Initiative 2018 – World Health Organization, UNICEF (free)

News release: WHO and UNICEF issue new guidance to promote breastfeeding in health facilities globally (free)

Related guideline: Protecting, promoting and supporting breastfeeding in facilities providing maternity and newborn services – World Health Organization (free)

Commentary: Hospitals must support breastfeeding which saves lives – WHO, UNICEF – Reuters (free)

 

3 – Systemic Antibiotics for the Treatment of Skin and Soft Tissue Abscesses: A Systematic Review and Meta-Analysis – Annals of Emergency Medicine (free)

Commentary: Meta-Analysis Favors Antibiotics After Drainage of Skin Abscesses – NEJM Journal Watch (free)

See related guideline with infographic: Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline – The BMJ (free) AND Meta-Analysis: Antibiotics for uncomplicated skin abscesses: systematic review and network meta-analysis – BMJ Open (free)

 

4 – Clinical Practice Guidelines for the Antibiotic Treatment of Community-Acquired Urinary Tract Infections – The Korean Society of Infectious Diseases and Korean Society for Chemotherapy (free)

 

5 – 2018 update of the EULAR recommendations for the management of Behçet’s syndrome – Annals of Rheumatic Disease (free)

Commentary: Behcet’s Syndrome: Treatment Guidelines Updated – MedPage Today (free registration required)

 

6 – The health, poverty, and financial consequences of a cigarette price increase among 500 million male smokers in 13 middle income countries: compartmental model study – The BMJ (free)

Editorial: The benefits of taxing cigarettes in middle income countries (free)

See also: To Improve Global Health, Tax the Things that are Killing Us (free policies, articles and commentaries) AND The Lancet Taskforce on NCDs and economics (free registration required for all articles and commentaries)

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: March 2018 – eCancer News (free)

 

8 – Laboratory-confirmed respiratory infections as triggers for acute myocardial infarction and stroke: a self-controlled case series analysis of national linked datasets from Scotland – European Respiratory Journal (free)

Commentaries: Flu and pneumonia infections increase risk of having a heart attack and stroke – European Respiratory Foundation, via Eurekalert (free) AND Do Pneumococcal and Respiratory Virus Infections Trigger Cardiovascular Morbidity? – NEJM Journal Watch (free for a limited period)

See also: related study published recently showing a similar six-fold increase in myocardial infarctions in the week following a flu diagnosis (link to abstract and commentaries).

 

9 – Advanced machine learning in action: identification of intracranial hemorrhage on computed tomography scans of the head with clinical workflow integration – NPJ Digital Medicine (free) (via @EricTopol see Tweet)

 

10 – Risk of Unnatural Mortality in People With Epilepsy – JAMA Neurology (free for a limited period)

Editorial: Deaths in Epilepsy: What We Are Missing (free for a limited period)

Commentaries: Patients with epilepsy have greater risk of unnatural death – OnMedica (free) AND Epilepsy Diagnosis Tied to Suicide, Accident Risk – MedPage Today (free registration required)

 


 

1 – Zika Virus Shedding in Semen of Symptomatic Infected Men – New England Journal of Medicine (free)

Editorial: Virus in Semen and the Risk of Sexual Transmission (free)

Commentaries: New findings on Zika virus in semen may alter CDC guidance – CIDRAP (free) AND Study suggests risk of sexual transmission of Zika may dissipate quickly – STAT (free)

 

2 – American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis – Gastroenterology (free)

Source: New Clinical Practice Guidelines, April 2018 Edition – Medscape (free registration required)

Related guideline: Clinical practice guideline: management of acute pancreatitis – Canadian Journal of Surgery (free)

 

3 – Guideline: Lyme disease – National Institute for Health and Care Excellence (free)

News release: New advice will help doctors spot and treat Lyme disease early, says NICE (free)

 

4 – β-Amyloid accumulation in the human brain after one night of sleep deprivation – Proceedings of the National Academies of Sciences (free)

Commentaries: Don’t lose sleep over reports that one bad night can spark dementia – NHS Choices (free) AND One night of sleep deprivation leads to increase in Alzheimer’s protein – New Atlas (free) AND Expert reaction to study investigating sleep deprivation and amyloid build up – Science Media Centre (free)

 

5 – Long-term risk of dementia among people with traumatic brain injury in Denmark: a population-based observational cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Study confirms link between traumatic brain injury and dementia – UW Medicine, via EurekAlert (free) AND Traumatic brain injury increases risk of dementia – OnMedica (free) AND Brain injury may increase dementia risk – NHS Choices (free)

Related articles: Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study – PLOS One (free) AND Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football – JAMA (free)

 

6 – NIA-AA Research Framework: Toward a biological definition of Alzheimer’s disease – Alzheimer’s & Dementia (free)

Commentaries: Scientists Push Plan To Change How Researchers Define Alzheimer’s – NPR (free) AND Researchers Propose New Alzheimer’s Definition Based on Biomarkers – MedPage Today (free registration required) AND New biological research framework for Alzheimer’s seeks to spur discovery – NIH / National Institute on Aging, via EurekAlert (fee)

 

7 – Guideline: Evaluation and Management of Testosterone Deficiency – American Urological Association (free)

Commentary: AUA: New Guidelines for Diagnosis, Management of Testosterone Deficiency – MPR (free)

Related Guideline: Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free)

 

8 – Estimating the health and economic effects of the proposed US Food and Drug Administration voluntary sodium reformulation: Microsimulation cost-effectiveness analysis – PLOS Medicine (free)

Commentaries: FDA’s Proposed Sodium Reduction Plan Could Have a Big Impact, Analysis Suggests – TCTMD (free) AND US FDA sodium reformulation targets projected to save lives and costs – PLOS, via EurekAlert (free) AND Study highlights the health and economic benefits of a US salt reduction strategy – University of Liverpool (free)

 

9 – Investing in non-communicable disease prevention and management to advance the Sustainable Development Goals – The Lancet (free registration required)

See complete series: The Lancet Taskforce on NCDs and economics (free registration required for articles and commentaries)

“Economic case to #BeatNCDs: benefit-cost ratio of investing in prevention and treatment of #NCDs is 5.6 for economic returns – 10.9 if social returns are included” (via @TheLancet see Tweet)

 

10 – Effectiveness of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment versus their combination in prevention of depressive relapse or recurrence (DRD study): a three-group, multicentre, randomised controlled trial – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary: Preventive cognitive therapy is an effective alternative and addition to antidepressants for preventing depression relapse, study finds – ACP Internist (free) AND Preventive Cognitive Therapy Helps Limit Depression Recurrence – NEJM Physician’s First Watch (free) AND Depression: preventive cognitive therapy improves outcome in recurrent depression – Univadis (free registration required)

 


 

1 – The State of US Health, 1990-2016: Burden of Diseases, Injuries, and Risk Factors Among US States – JAMA (free)

Editorial: Toward a United States of Health: Implications of Understanding the US Burden of Disease (free)

Author interview: US Burden of Diseases, Injuries, and Disease Risk Factors, 1990-2016 (free)

Commentaries: Warning Signs: New US Health Study Reveals ‘Dangerous Disparities’ among States – Institute for Health Metrics and Evaluation (free) AND The states where disease and death are highest: A visual guide – CNN (free)

“NEW global burden of disease study on US health is most comprehensive state-by-state health assessment ever undertaken & includes estimates for all 50 states & Washington DC & the nation overall” (via @IHME_UW see Tweet)

 

2 – Associations of Fitness, Physical Activity, Strength, and Genetic Risk With Cardiovascular Disease: Longitudinal Analyses in the UK Biobank Study – Circulation (free PDF for a limited period)

Commentaries: Outrunning Your Genes: Exercise Offsets CVD Events Among High-Risk Subjects – TCTMD (free) AND When heart disease runs in the family, exercise tied to lower risk – Reuters (free)

 

3 – Honey for acute cough in children – Cochrane Library (link to abstract – $ for full-text)

Summary: Honey for acute cough in children – Cochrane Library (free)

“Honey probably relieves cough symptoms to a greater extent than no treatment, diphenhydramine, and placebo, but may make little or no difference compared to dextromethorphan.” 

 

4 – Effect of pasta in the context of low-glycaemic index dietary patterns on body weight and markers of adiposity: a systematic review and meta-analysis of randomised controlled trials in adults – BMJ Open (free)

Commentary: Pasta unlikely to cause weight gain as part of a healthy diet – NHS Choices (free)

 

5 – Weight loss as a predictor of cancer in primary care: a systematic review and meta-analysis – British Journal of General Practice (free)

Commentaries: Weight loss is an important predictor of cancer – University of Oxford (free)

 

6 – A Mini Review of the Zoonotic Threat Potential of Influenza Viruses, Coronaviruses, Adenoviruses, and Enteroviruses – Frontiers in Public Health (free)

Source: Global Health NOW Newsletter

 

7 – EASL Clinical Practice Guidelines: Management of alcohol-related liver disease – Journal of Hepatology (free)

 

8 – EASL Clinical Practice Guidelines: Management of hepatocellular carcinoma – Journal of Hepatology (free)

 

9 – EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)

 

10 – Associations Between Brain Structure and Connectivity in Infants and Exposure to Selective Serotonin Reuptake Inhibitors During Pregnancy – JAMA Pediatrics (free for a limited period)

Author interview: Associations Between SSRI Exposure During Pregnancy and MRI-Assessed Brain Structure and Connectivity in Infants (free)

Commentaries: We’re beginning to learn how moms’ antidepressants can affect fetuses – VOX (free) AND MRI study finds prenatal exposure to certain antidepressants may alter brain development – Health Imaging (free) AND SSRI use in pregnancy may affect fetal brain development – OnMedica (free) AND Antidepressants in pregnancy tied to changes in babies’ brains – Reuters (free)

 


 

1 – Clinical Practice Guideline:  Iron Deficient Anemia – Toward Optimized Practice (TOP) (free PDF)

See also: Summary and Algorithm (free PDF)

Related: see all TOP Clinical Practice Guidelines, a practical resource for Family Physicians at the point of care.

 

2 – Dialysis Initiation and Mortality Among Older Veterans With Kidney Failure Treated in Medicare vs the Department of Veterans Affairs – JAMA Internal Medicine (free for a limited period)

Invited commentary: Appropriate Time for Chronic Dialysis Initiation: A Cause for Humility (free for a limited period)

Related articles: Treatment decisions for older adults with advanced chronic kidney disease – BMC Nephrology (free) AND Timing of Dialysis Initiation – What Has Changed Since IDEAL? – Seminars in Nephrology (free)

 

3 – Childhood predictors of lung function trajectories and future COPD risk: a prospective cohort study from the first to the sixth decade of life – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Related article: Lung function trajectories from pre-school age to adulthood and their associations with early life factors: a retrospective analysis of three population-based birth cohort studies – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Commentaries: Three-quarters of COPD cases are linked to childhood risk factors that are exacerbated in adulthood – The Lancet, via ScienceDaily (free) AND Early intervention may minimise later lung problems – The Melbourne Newsroom (free) AND COPD Risk Factors Evident Early in Life – NEJM Physician’s First Watch (free)

 

4 – Seminar: Malaria – The Lancet (free registration required)

 

5 – Perspective: Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)

 

6 – The burden of online friends: the effects of giving up Facebook on stress and well-being – The Journal of Social Psychology (free)

Commentaries: Quitting Facebook can reduce stress – University of Queensland (free) AND Giving up Facebook leads to a drop in the stress-related hormone cortisol, study finds – PsyPost (free) AND Does Quitting Facebook Really Make You Less Happy? Probably Not – Forbes (free) AND Want to de-stress? Delete Facebook, study suggests – Medical News Today (free)

 

7 – Alpha-blockers as medical expulsive therapy for ureteral stones – Cochrane Library (link to abstract – $ for full-text)

Summary: Alpha-blockers for ureteral stones in adult patients with symptoms of stone disease – Cochrane Library (free)

 

8 – Consolidated principles for screening based on a systematic review and consensus process – Canadian Medical Association Journal (free)

 

9 – AHA Policy Statement: Projected Costs of Informal Caregiving for Cardiovascular Disease: 2015 to 2035 – Circulation (free)

Commentary: Skyrocketing Costs of CVD Will Be Amplified by Informal Caregiving: AHA – TCTMD (free)

 

10 – Pharmaceutical Industry Payments and Oncologists’ Selection of Targeted Cancer Therapies in Medicare Beneficiaries – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Payments to Doctors Linked to Prescription Practices for Two Cancer Types – University of North Carolina (free) AND Pharma Dollars Appear to Sway Oncologist Rx Habits – MedPage Today (free registration required)

 


 

1 – World Health Day (7 April 2018) – World Health Organization (free resources)

See also: Campaign Essentials / Key Messages / and WHO’s Universal Health Coverage Website

WHO’s theme for this year world health day is Universal Health Coverage. “Health is a human right. It’s time for Universal Health Coverage for everyone, everywhere”. (via @WHO  see Tweet)

 

2 – New Series from The Lancet Journals: The Lancet Taskforce on NCDs and economics (free registration required for all articles and commentaries)

Commentaries: Tax sugar, alcohol and tobacco to help the poor, say experts – The Guardian (free) AND Taxes on soft drinks, alcohol and tobacco are of most benefit to the poor – Imperial College London (free)

See also: To Improve Global Health, Tax the Things that are Killing Us (free policies, articles and commentaries)

 

3 – Preventing type 2 diabetes in people with ‘prediabetes’: do diet and exercise work? – Evidently Cochrane (free)

 

4 – Physiotherapy education before major abdominal surgery reduces lung complications – NIHR Signal (free)

See original article: Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial – The BMJ (free)

 

5 – Guideline summaries: 2018 ESC Guidelines for Diagnosis and Management of Syncope – American College of Cardiology (free) AND Practical Instructions for the 2018 ESC Syncope Guidelines – American College of Cardiology (free)

Original Documents: 2018 ESC Guidelines for the diagnosis and management of syncope (free) AND Practical Instructions for the 2018 ESC Guidelines for the diagnosis and management of syncope (free)

 

6 – “A Guide to Gutsy Living”: Patient-Driven Development of a Pediatric Ostomy Toolkit – Pediatrics (free)

Commentary: New guide helps kids, adolescents living with ostomies – Reuters (free)

 

7 – Percutaneous vertebroplasty for osteoporotic vertebral compression fracture – Cochrane Library (link to abstract – $ for full-text)

Summary: Featured Review: Vertebroplasty for treating spinal fractures due to osteoporosis – Cochrane Library (free)

High quality evidence shows that vertebroplasty does not provide more clinically important benefits than placebo but may cause people harm”.

 

8 – EASL Clinical Practice Guidelines on hepatitis E virus infection – Journal of Hepatology (free)

 

9 – Guideline on management of the acute asthma attack in children by Italian Society of Pediatrics – Italian Journal of Pediatrics (free)

 

10 – Outpatient Talc Administration by Indwelling Pleural Catheter for Malignant Effusion – New England Journal of Medicine (link to abstract – $ for full-text) (see Visual Abstract)

Commentary: Outpatient talc administration improves malignant effusion outcomes – Chest Physician (free)

 


 

1 – Improving the Safety of Opioid Use for Acute Noncancer Pain in Hospitalized Adults: A Consensus Statement From the Society of Hospital Medicine – Journal of Hospital Medicine (free)

Commentary: New guidance for safe opioid prescribing for hospitalized patients with acute pain – Beth Israel Deaconess Medical Center, via EurekAlert (free)

 

2 – Guideline: Regional Anesthesia in the Patient Receiving Antithrombotic or Thrombolytic Therapy: American Society of Regional Anesthesia and Pain Medicine (free)

 

3 – Guideline: Interventional Spine and Pain Procedures in Patients on Antiplatelet and Anticoagulant Medications – American Society of Regional Anesthesia and Pain Medicine (free)

 

4 – Meta-analysis: Nasal vs Oronasal CPAP for OSA Treatment – CHEST (free)

Source: EvidenceAlerts

 

5 – Management of Patients With Aortic Valve Stenosis – Mayo Clinic Proceedings (free)

 

6 – Metabolic recovery from heavy exertion following banana compared to sugar beverage or water only ingestion: A randomized, crossover trial – PLOS One (free)

Commentary: Bananas vs. Sports Drinks? Bananas Win in Study – The New York Times (10 articles per month are free)

 

7 – Sleep deficiency and motor vehicle crash risk in the general population: a prospective cohort study – BMC Medicine (free)

Commentary: Sleep deficiency increases risk of a motor vehicle crash – Brigham and Women’s Hospital, via ScienceDaily (free)

Study finds that sleep deficiency due to either sleep apnea or insufficient sleep duration is strongly associated with motor vehicle crashes, regardless of one’s self-reported sleepiness level” (from ScienceDaily)

 

8 – Breast Cancer Screening in Women at Higher-Than-Average Risk: Recommendations From the ACR – Journal of the American College of Radiology (free)

Commentaries: ACR Recommends More Aggressive Breast Cancer Screening for Higher-Than-Average-Risk Women – Imaging Technology News (free) AND New ACR/SBI Breast Cancer Screening Guidelines Call for Significant Changes to Screening Process – American College of Radiology, via NewsWise (free)

See related guideline with a more conservative approach: Breast Cancer: Screening – U.S. Preventive Services Task Force (free)

 

9 – Multisociety Consensus Quality Improvement Revised Consensus Statement for Endovascular Therapy of Acute Ischemic Stroke – Journal of Vascular and Interventional Radiology (free)

Related guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF)

 

10 – Cognitive Aging and Long-Term Maintenance of Attentional Improvements Following Meditation Training – Journal of Cognitive Enhancement (free)

Commentary: Seven-year follow-up shows lasting cognitive gains from meditation – University of California, via ScienceDaily (free)

 


 

1 – Routine Assessment and Promotion of Physical Activity in Healthcare Settings: A Scientific Statement From the American Heart Association (free PDF)

Commentary: Promoting Physical Activity in Routine Health Care: Time to Walk the Talk (free)

Top Ten Things to Know: Routine Assessment and Promotion of Physical Activity in Healthcare Settings (free PDF)

 

2 – Tax sugar, alcohol and tobacco to help the poor, say experts – The Guardian (free)

See also: To Improve Global Health, Tax the Things that are Killing Us (free policies, articles and commentaries)

 

3 – Preconception Blood Pressure Levels and Reproductive Outcomes in a Prospective Cohort of Women Attempting Pregnancy – Hypertension (link to abstract – $ for full-text)

Commentaries: Higher blood pressure before pregnancy may increase miscarriage risk – American Heart Association, via ScienceDaily (free) AND High blood pressure before pregnancy linked to heightened miscarriage risk – OnMedica (free) AND Slightly high blood pressure before pregnancy tied to miscarriage risk – Reuters (free) AND Higher Blood Pressure Before Conception Tied to Miscarriage – MedPage Today (free registration required)

 

4 – Postnatal Zika virus infection is associated with persistent abnormalities in brain structure, function, and behavior in infant macaques – Science Translational Medicine (link to abstract – $ for full-text)

Commentaries: Monkey study suggests Zika infection in infancy could cause brain damage – STAT (free) AND Zika Exposure Even after Birth May Lead to Brain Damage – Scientific American (free)

 

5 – Associations of Bariatric Surgery With Changes in Interpersonal Relationship Status: Results From 2 Swedish Cohort Studies – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Relationship changes after bariatric surgery – University of Gothenburg, via EurekAlert (free) AND Big weight loss may bring big relationship changes – UPI (free)

 

6 – Time to Endovascular Treatment and Outcome in Acute Ischemic Stroke: MR CLEAN Registry Results – Circulation (link to abstract – $ for full-text)

Commentary: Time to endovascular therapy predicted functional outcome after stroke in registry study – ACP Hospitalist (free)

“Every hour of delay from stroke onset to the start of endovascular therapy resulted in a 5.3% decreased probability of functional independence” (from ACP Hospitalist)

 

7 – Change in Overweight from Childhood to Early Adulthood and Risk of Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Heavy kids who normalize weight in childhood can avoid extra diabetes risk – Reuters (free) AND Normalizing Weight By Puberty May Drop Diabetes Risk Later – Medscape (free registration required)

 

8 – Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma – NEJM (link to abstract – $ for full-text)

Quick Take Video Summary: Sunitinib or Nivolumab plus Ipilimumab for Renal-Cell Carcinoma (free)

Overall survival and objective response rates were significantly higher with nivolumab plus ipilimumab”.

 

9 – Review: Management of Left Main Coronary Artery Disease – Journal of the American Heart Association (free for a limited period)

 

10 – Socioeconomic status, non-communicable disease risk factors, and walking speed in older adults: multi-cohort population based study – The BMJ (free)

“New work in @bmj_latest shows poverty increases ageing. Measured by walking speed. 60 y.o. men of lower social class walk like 66 y.o. men of higher social class. As important as physical inactivity, obesity or diabetes. Worse than smoking”. (via @astaines see Tweet)

 


 

1 – Association of a Negative Wealth Shock With All-Cause Mortality in Middle-aged and Older Adults in the United States – JAMA (free for a limited period)

Commentaries: Financial Ruin Can Be Hazardous To Your Health – NPR (free) AND Losing your nest egg can kill you – Northwestern University, via ScienceDaily (free)

“People have a 50 percent higher risk of death if they suffer a shocking financial loss” (via ScienceDaily)

 

2 – Characteristics of Infant Deaths during Sleep While Under Nonparental Supervision – The Journal of Pediatrics (free)

Commentaries: Babies At Risk Of Being Put In Unsafe Sleep Positions By Babysitters And Relatives, Study Suggests – HuffPost (free) AND Infant death study reveals dangerous sleep practices among babysitters, relatives, others – University of Virginia Health System, via ScienceDaily (free)

Related Guideline: SIDS and Other Sleep-Related Infant Deaths: Updated 2016 Recommendations for a Safe Infant Sleeping Environment – Task Force on Sudden Infant Death Syndrome, American Academy of Pediatrics (free)

 

3 – Hospitals are germy, noisy places. Some acutely ill patients are getting treated at home instead – The Washington Post (a few articles per month are free)

Source: STAT Newsletter

 

4 – Paying Hospitals To Keep People Out Of Hospitals? It Works In Maryland – Kaiser Health News (free)

 

5 – Serum n–6 polyunsaturated fatty acids and risk of death: the Kuopio Ischaemic Heart Disease Risk Factor Study – American Journal of Clinical Nutrition (link to abstract – $ for full-text)

Commentaries: High omega-6 levels can protect against premature death – University of Eastern Finland, via EurekAlert (free) AND Could omega-6 fatty acids help us live longer? – MedicalNewsToday (free) AND Omega-6s in Nuts, Seeds and Vegetable Oils May Aid the Heart – The New York Times (10 articles per month are free)

 

6 – ‘Faith Healing’ And Chest Pain: Heart Controversy Points Up Confounding Power Of Reassurance – CommonHealth (free)

Related: More Controversy Over Major Cardiology Clinical Trial – Cardiobrief (free) AND Cardiology World Erupts Into Controversy Over Change In Major Clinical Trial – Cardiobrief (free) AND Moving the Goalposts Into Unblinded Territory – Circulation: Cardiovascular Quality and Outcomes (free)

 

7 – Richard Lehman’s journal reviews, 3 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Acute chest pain evaluation using coronary computed tomography angiography compared with standard of care: a meta-analysis of randomised clinical trials – Heart (link to abstract – $ for full-text)

See commentary in: Articles of the month (March 2018) – First10EM (free)

Se related meta-analysis with similar results: Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials – The BMJ (free)

“Bottom line: In the RCTs we have to date, CCTA demonstrate no benefit, but leads to an increase in unnecessary invasive procedures” (from First10EM).

 

9 – Migraine and the risk of cardiovascular and cerebrovascular events: a meta-analysis of 16 cohort studies including 1 152 407 subjects – BMJ Open (free)

Commentary: Migraines tied to higher risk for stroke, MI in large meta-analysis – Univadis (free registration required)

 

10 – Effects of supplemental oxygen therapy in patients with suspected acute myocardial infarction: a meta-analysis of randomised clinical trials – Heart (link to abstract – $ for full-text)

Related guideline: BTS Guideline for oxygen use in healthcare and emergency settings – British Thoracic Society (free)

“These findings from eight RCTs support departing from the usual practice of administering oxygen in normoxaemic patients”.

 


 

1 – Guideline Summary: Cardiovascular Disease and Risk Management: Review of the American Diabetes Association Standards of Medical Care in Diabetes 2018 – Annals of Internal Medicine (free)

 

2 – Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy and Allergic Diseases in Early Childhood – JAMA Pediatrics (free for a limited period)

Author interview: Association Between Use of Acid-Suppressive Medications and Antibiotics During Infancy And Allergic Diseases in Early Childhood (free)

Commentaries: Antacids, antibiotics for infants linked to later allergies – STAT (free) AND Antacids, antibiotics for infants linked to later allergies – Associated Press (free) AND Giving Babies Antibiotics or Antacids May Increase Allergy Risk – The New York Times (10 articles per month are free)

 

3 – ‘Aggressive’ New Advance Directive Would Let Dementia Patients Refuse Food – Kaiser Health News (free)

See website: End of Life Choices

Related initiatives: This Startup Makes End-Of-Life Planning A Piece Of Cake (free) AND New Document for Patients: Advanced Health Directive for Dementia (free document and commentaries)

 

4 – Quantifying population-level health benefits and harms of e-cigarette use in the United States – PLOS One (free)

Commentaries: Study Suggests E-cigarettes Cause More Harm Than Good – AAFP News (free)

“Some Adults May Quit Smoking Traditional Cigarettes, But More Teens and Young Adults Will Start” (from AAFP)

 

5 – Mindfulness-based intervention to increase resilience to stress in university students (the Mindful Student Study): a pragmatic randomised controlled trial – The Lancet (free)

Commentaries: Mindfulness training in higher education students – The Lancet (free) AND Mindfulness may help university students reduce stress – The Mental Elf (free)

 

6 – 2018 European Thyroid Association (ETA) Guidelines for the Management of Amiodarone-Associated Thyroid Dysfunction – European Thyroid Journal (free)

 

7 – Summary: Clinician Guide to the ABCs of Primary and Secondary Prevention of Atherosclerotic Cardiovascular Disease – American College of Cardiology (free)

 

8 – Review: Diagnosis and Management of Acute Ischemic Stroke – Mayo Clinic Proceedings (free)

Related guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF) AND Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)

 

9 – Review: Mechanisms and Management of Acute Pancreatitis – Gastroenterology Research and Practice (free)

Source: Critical Care Reviews Newsletter

 

10 – Increased coronary heart disease and stroke hospitalisations from ambient temperatures in Ontario – Heart (free)

Related study: Big Swings in Daily Temperatures Linked to Spikes in MI Rates – TCTMD (free)

“Cold and hot weather associated with risk of cardiovascular disease hospitalization” (via @kamleshkhunti see Tweet)

 


 

1 – Moderate‐to‐Vigorous Physical Activity and All‐Cause Mortality: Do Bouts Matter? – Journal of the American Heart Association (free for a limited period)

Editorial: Accumulation of Moderate‐to‐Vigorous Physical Activity and All‐Cause Mortality (free)

Commentaries: Whether sustained or sporadic, exercise offers same reductions in premature death risk – Duke University Medical Center, via ScienceDaily (free) AND Get 150 minutes/week of moderate physical activity: It doesn’t matter how – National Cancer Institute (free) AND Every bit of exercise counts in reducing risk of early death: Study – CBC (free) AND Those 2-Minute Walk Breaks? They Add Up – The New York Times (10 articles per month are free) 

 

2 – Update on prevention, diagnosis, and treatment of chronic hepatitis B: AASLD 2018 hepatitis B guidance – Hepatology (free)

 

3 – Treating Subthreshold Depression in Primary Care: A Randomized Controlled Trial of Behavioral Activation With Mindfulness – Annals of Family Medicine (free)

Commentaries: Mindfulness Intervention Can Prevent Depression, Study Finds – Mad in America (free) AND Could mindfulness prevent major depression? – Medical News Today (free) AND Meditation May Reduce Depression in Primary Care – Medscape (free registration required)

 

4 – Viewpoint: Charter on Physician Well-being – JAMA (free)

 

5 – To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record – Harvard Business Review (a few articles per month are free)

Related: Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout – National Academy of Medicine (free) AND Date Night with the EHR – NEJM Catalyst (free) AND Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

 

5 – The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines – Gut (free)

 

6 – Report: Securing safe roads: the politics of change – World Resources Institute Ross Center for Sustainable Cities (free news release and PDF)

Commentary: Death Toll On World’s Roads Grows, But Not Will To Stop It, New Report Finds – Forbes (free)

Related World Bank Report: The High Toll of Traffic Injuries : Unacceptable and Preventable – The World Bank (free PDF)

Related WHO Report: Save LIVES: a road safety technical package (free)

Source: International Health Policies Newsletter (free PDF)

 

7 – Mapped: the global epidemic of ‘lifestyle’ disease in charts – The Telegraph (free) (via @kamleshkhunti see Tweet)

 

8 – Illustrative Teaching Case: Oral Contraceptives and Ischemic Stroke Risk – Stroke (free for a limited period)

Key points: Oral Contraceptives and Ischemic Stroke Risk – American College of Cardiology (free)

 

9 – Macrolide antibiotics for bronchiectasis – Cochrane Library (link to abstract – $ for full-text)

Summary: Macrolide antibiotics for bronchiectasis – Cochrane Library (free)

Long-term macrolide therapy may reduce the frequency of exacerbations and improve quality of life, although supporting evidence is derived mainly from studies of azithromycin, rather than other macrolides, and predominantly among adults rather than children. However, macrolides should be used with caution, as limited data indicate an associated increase in microbial resistance”.

 

10 – The most affected health domains after ischemic stroke – Neurology (link to abstract – $ for full-text)

Commentaries: Stroke affects more than just the physical – American Academy of Neurology, via EurekAlert (free) AND Physical, Executive Function Most Affected After Ischemic Stroke – Physician’s Weekly (free) AND Nonphysical Problems Common After Stroke – Medscape (free registration required) AND Mild Stroke Alters Far More Than the Physical – MedPage Today (free)

“Mild disability still comes with social, cognitive impact, study suggests” (from MedPage Today)

 


 

1 – Duration of Adjuvant Chemotherapy for Stage III Colon Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Duration of Chemotherapy for Colon Cancer (free)

Commentaries: Colon cancer chemo could be halved after surgery – Cancer Research UK, via MedicalXpress (free) AND Global cancer trial sets new standard for post-surgery chemotherapy – National Cancer Institute, via MedicalXpress (free)

 

2 – Long-term Thromboembolic Risk in Patients With Postoperative Atrial Fibrillation After Coronary Artery Bypass Graft Surgery and Patients With Nonvalvular Atrial Fibrillation – JAMA Cardiology (free for a limited period)

Commentaries: Postoperative A-fib Not as Bad as Nonsurgical A-fib for Thromboembolism – TCTMD (free) AND Fib after CABG linked to minimal long-term stroke risk – Cardiovascular Business (free)

 

3 – Venous Thromboembolism Prevention in Emergency General Surgery: A Review – JAMA Surgery (free for a limited period)

Commentary: VTE Risk Up in Most Emergency General Surgery Patients – Physician’s Weekly (free)

 

4 – Behavioral interventions as a treatment for epilepsy: A multicenter randomized controlled trial – Neurology (link to abstract – $ for full-text)

Commentaries: Can Learning Stress-Reducing Techniques Help Reduce Seizures? – American Academy of Neurology, via NewsWise (free) AND Stress Reduction Techniques Cut Seizure Rate in Severe Epilepsy – Medscape (free registration required) AND Stress-Reducing Techniques Lead to Fewer Seizures – MedPage Today (free registration required)

 

5 – IOC consensus statement: dietary supplements and the high-performance athlete – British Journal of Sports Medicine (free)

 

6 – What We Know (and Don’t Know) About How to Lose Weight – The New York Times (10 articles per month are free)

“One conclusion from a much-discussed study: The best diet is the one you can stick to”.

 

7 – High red and processed meat consumption is associated with non-alcoholic fatty liver disease and insulin resistance – Journal of Hepatology (link to abstract – $ for full-text) (via @kamleshkhunti see Tweet)

Commentaries: High Consumption Of Red And Processed Meat Linked to Non-Alcoholic Fatty Liver Disease And Insulin Resistance – EASL (free) AND More People Can Afford Meat Now, And Hepatologists Claim That Is Causing Liver Disease – Science 2.0 (free)

 

8 – Patent foramen ovale closure vs. medical therapy for cryptogenic stroke: a meta-analysis of randomized controlled trials – European Heart Journal (free)

“5-study EHJ meta analysis confirms value of PFO closure after cryptogenic stroke. “Number Needed to Close”: 178 pts to prevent one stroke over 1 year. Size matters (no effect for small shunts, “NNC” 96 for large shunts)” (via @Steph_Achenbach see Tweet)

 

9 – Report: Multi-drug resistant gonorrhoea in England: 2018 – Public Health England (free)

Commentaries:  In world first, UK reports high-level gonorrhea resistance – CIDRAP (free) AND First case of super-resistant gonorrhea reported – CNN (free)

Related: Scientists warn that antibiotic-resistant gonorrhoea is on the rise – World Health Organization (free) AND Untreatable Gonorrhea Is Rapidly Spreading. Here’s What You Need to Know – TIME Health (free)

 

10 – The Effect of Door-to-Diuretic Time on Clinical Outcomes in Patients With Acute Heart Failure – JACC Heart Failure (free)

Commentaries: Quicker Diuretics Not Associated With Better Outcomes in Acute Heart Failure – TCTMD (free) AND Door-to-Diuretic Time in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free) AND Door-to-diuretic time didn’t affect mortality from heart failure in Korean registry – ACP Hospitalist (free)

“Overall, there isn’t strong evidence of benefit from early use of diuretics and “the overriding consideration should remain ‘get it right’ rather than ‘do it fast,’” the editorial concluded”. (from ACP)

 


 

1 – Guideline: Otitis media (acute): antimicrobial prescribing – National Institute for Health and Care Excellence (NICE) (free)

Commentaries: Most common ear infections should not be treated with antibiotics, says NICE (free) AND Common ear infections don’t need antibiotics, health watchdog says – The Guardian (free) AND Antibiotics not recommended for acute otitis, says NICE – OnMedica (free)

Related guideline: Clinical Practice Guideline: Otitis Media with Effusion (Update) – Otolaryngol Head Neck Surg (free) AND Executive Summary – Otolaryngol Head Neck Surg (free)

 

2 – Guideline: Stop smoking interventions and services – National Institute for Health and Care Excellence (NICE) (free)

Commentaries: Help people make informed decisions when they want to quit smoking, says NICE and Public Health England – NICE News Release (free) AND Doctors should tell patients e-cigarettes ‘less harmful than smoking but not without risk’ – iNews (free)

Related guidelines and reports:  E-cigarettes and heated tobacco products: evidence review – Public Health England (free PDF) AND Public Health Consequences of E-Cigarettes – National Academies of Sciences, Engineering, and Medicine (free PDF) AND E-cigarettes: balancing risks and opportunities – British Medical Association (free PDF) AND Nicotine without smoke: Tobacco harm reduction – Royal College of Physicians (free summary and PDF) AND RCGP Position Statement on the use of electronic nicotine vapour products (E-Cigarettes) – Royal College of General Practitioners (free PDF)

 

3 – Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial – The Lancet Infectious Diseases (free registration required)

Commentaries: Ivermectin: repurposing an old drug to complement malaria vector control – The Lancet Infectious Diseases (free registration required) AND LSTM study shows drug that kills mosquitoes could be used to fight malaria – London School of Tropical Medicine (free) AND Common anti-parasitic could be new tool for malaria control – OnMedica (free)

 

4 – Psychosocial Effects of Parent-Child Book Reading Interventions: A Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentaries: Reading programs may teach parents and kids more than literacy – Reuters (free) AND Parent-child reading interventions have positive psychosocial effects – 2 Minute Medicine (free)

 

5 – Pain Management in Cancer Center Inpatients: A Cluster Randomized Trial to Evaluate a Systematic Integrated Approach—The Edinburgh Pain Assessment and Management Tool – Journal of Clinical Oncology (free)

Commentaries: Cancer patients’ pain eased by simple bedside chart – University of Edinburgh, via ScienceDaily (free) AND Bedside Assessment Tool Improves Worst Pain in Patients With Cancer – Oncology Nurse Advisor (free) AND Effect of Integrated Assessment and Management Tool on Pain Management in Cancer Center Inpatients – The ASCO Post (free)

 

6 – Last Month in Oncology with Dr. Bishal Gyawali: February 2018 – eCancer News (free)

 

7 – Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe in 2015: magnitude, temporal trends and projections – British Journal of Ophthalmology (free)

Commentary: Half of vision impairment in first world is preventable – Cambridge Network (free)

 

8 – Life After Stroke: a round up of Cochrane evidence – Evidently Cochrane (free)

 

9 – Smoking and smoking cessation in relation to risk of diabetes in Chinese men and women: a 9-year prospective study of 0·5 million people – The Lancet Public Health (free)

Commentaries: Combating diabetes in China: a long-term perspective is needed – The Lancet Public Health (free) AND Smoking linked with higher risk of type 2 diabetes – University of Oxford (free)

“Among Chinese adults, smoking associated with 18-33% increased risk of diabetes” (via @kamleshkhunti see Tweet)

 

10 – A Comparison of the Quick-SOFA and Systemic Inflammatory Response Syndrome Criteria for the Diagnosis of Sepsis and Prediction of Mortality: A Systematic Review and Meta-Analysis – Chest (free)

Related meta-analysis and commentaries: Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text) AND For mortality prediction, qSOFA has poor sensitivity, moderate specificity, review finds – ACP Hospitalist (free) AND Systemic inflammatory response syndrome criteria may be more sensitive than quick sequential organ failure assessment for predicting mortality in patients with suspected infection – 2 Minute Medicine (free)

“The SIRS was significantly superior to the qSOFA for sepsis diagnosis, and the qSOFA was slightly better than the SIRS in predicting hospital mortality. The association of both criteria could provide a better model to initiate or escalate therapy in patients with sepsis”.

 


 

1 – Special Report: The IARC Perspective on Colorectal Cancer Screening – New England Journal of Medicine (free)

Commentaries: The IARC perspective on colorectal cancer screening – eCancer News (free) AND WHO Group Says Evidence Favors Most Forms of Colorectal Cancer Screening – NEJM Physician’s First Watch (free)

 

2 – European evidence-based guidelines on pancreatic cystic neoplasms – Gut (free)

 

3 – The Assessment of Pain in Older People: UK National Guidelines – Age and Ageing (free)

 

4 – Fast and accurate view classification of echocardiograms using deep learning – npj Digital Medicine (free)

Commentaries: AI is Quicker, More Effective Than Humans in Analyzing Heart Scans – University of California San Francisco (free) AND Study: AI faster, more accurate than humans at analyzing heart scans – UPI (free) AND AI model 98% accurate in ECG classification—outperforming cardiologists – Health Imaging (free)

 

5 – Efficacy of foot orthoses for the treatment of plantar heel pain: a systematic review and meta-analysis – British Journal of Sports Medicine (link to abstract – $ for full-text)

Commentaries: Pricey orthotic insoles aren’t worth the cost – UPI (free) AND Custom-Made Foot Orthotics No Benefit for Plantar Heel Pain – Physician’s Briefing (free) AND Custom-made foot orthoses appear to be no better than over-the-counter insoles or other treatments – MedicalXpress (free) AND Foot orthotics may not be superior to conservative treatment for relieving plantar heel pain – ACP Internist (free)

 

6 – Electronic Health Record Usability Issues and Potential Contribution to Patient Harm – JAMA (link to abstract – $ for full-text)

Commentaries: EHR Usability Linked to Possible Patient Harms, Study Finds – AJMC (free) AND EHRs May Be Tied to Potential Patient Harm, Study Suggests – Medscape (free registration required)

 

7 – The human microbiome: why our microbes could be key to our health – The Guardian (free) (via @trished see Tweet)

 

8 – The Truth Wears Off: Is there something wrong with the scientific method? – The New Yorker (free)

“An excellent New Yorker article on regression to the mean. Extremely relevant to the practice of evidence-based medicine” (via @rajshekharucms see Tweet)

 

9 – Tele-Monitoring Can Reduce Medical Appointments For Low-Risk Pregnancies – Kaiser Health News (free)

Related commentary: How Mayo Clinic Is Simplifying Prenatal Care for Low-Risk Patients – Harvard Business Review (a few articles per month are free)

Related articles: Effectiveness of Telemonitoring in Obstetrics: Scoping Review – Journal of Medical Internet Research (free) AND Assessing the Effect of mHealth Interventions in Improving Maternal and Neonatal Care in Low- and Middle-Income Countries: A Systematic Review – PLOS One (free)

 

10 – Global prevalence, treatment, and prevention of hepatitis B virus infection in 2016: a modelling study – The Lancet Gastroenterology & Hepatology (free registration required)

Commentaries: Delineating the global challenges of hepatitis B virus infection – The Lancet Gastroenterology & Hepatology (free registration required) AND 1 in 20 people with hepatitis B receive care worldwide, study says – UPI (free) AND Scientists warn 90% of hepatitis B sufferers remain unaware of silent killer – The Guardian (free)

 


 

1 – Global increase and geographic convergence in antibiotic consumption between 2000 and 2015 – Proceedings of the National Academy of Sciences (free)

Commentaries: Calls to rein in antibiotic use after study shows 65% increase worldwide – The Guardian (free) AND Global antibiotic use rises, fueled by economic growth – CIDRAP (free) AND Surge In Antibiotics Is A Boon For Superbugs – NPR (free) AND As antibiotics fail, global consumption of antibiotics skyrockets, further driving drug resistance – MedicalXpress (free)

 

2 – Newly Revised: Curriculum for Educators and Residents (Version 4.0) – American College of Physicians (free)

News release: ACP introduces updated High Value Care Curriculum for educators and residents – ACP Internist (free)

“The High Value Care Curriculum (HVC) was jointly developed by ACP and the Alliance for Academic Internal Medicine (AAIM) to train physicians to be good stewards of limited health care resources”.

 

3 – Ethical Obligations Regarding Short-Term Global Health Clinical Experiences: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

Commentaries: Ethical Guidance for Volunteer Medical Trips Issued by ACP – Medscape (free registration required) AND Ethical Duties ID’d for Short-Term Global Health Experiences – Physician’s Briefing (free)

 

4 – Viewpoint: Driving Under the Influence of Cannabis: An Increasing Public Health Concern – JAMA (free for a limited period)

 

5 – Antibiotic Therapy Duration in US Adults With Sinusitis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Sinus Infections: Majority of Antibiotics Prescriptions Longer Than Recommended – MedicalResearch.com (free) AND CDC Study Says Sinus Infections Are Treated With Antibiotics Longer Than Necessary – AJMC (free) AND Most Courses of Antibiotics for Sinusitis Are Too Long – NEJM Physician’s First Watch (free)

Related Guideline: IDSA Clinical Practice Guideline for Acute Bacterial Rhinosinusitis in Children and Adults – Clinical Infectious Diseases (free)

 

6 – Clinical Updates: Palliative radiotherapy – The BMJ (free)

Clinical Update for non-specialists on the benefits, practicalities, and side effects of palliative radiotherapy.

 

7 – Richard Lehman’s journal reviews, 26 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – The dark truth about chocolate – The Guardian (free)

Related: Dark chocolate is now a health food. Here’s how that happened – VOX (free)

“Grand health claims have been made about chocolate, but while it gives us pleasure, can it really be good for us?”

 

9 – Viewpoint: Individualizing Blood Pressure Targets for People With Diabetes and Hypertension: Comparing the ADA and the ACC/AHA Recommendations – JAMA (free for a limited period)

 

10 – Association of E-Cigarette Use With Smoking Cessation Among Smokers Who Plan to Quit After a Hospitalization: A Prospective Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Some e-cigarette users may struggle to quit smoking – Reuters (free) AND Expert reaction to ecigs and smoking cessation – Science Media Centre (free) AND Could E-Cigarettes Foil Smoking Cessation Efforts After Hospital Discharge? – NEJM Physician’s First Watch (free)

“The study is consistent with the hypothesis that smokers need to use e-cigarettes regularly and daily and switch completely from cigarettes to e-cigarettes for them to have the greatest chance of help” (from Reuters)

 


 

1 – #WorldTBDay (March 24, 2018) – 1 – World TB Day, 24 March 2018 – World Health Organization (free resources)

See also: WHO publications on tuberculosis

 

2 – #WorldTBDay (March 24, 2018) – The World Health Organization standards for tuberculosis care and management – European Respiratory Journal (free)

Original Guideline: Compendium of WHO guidelines and associated standards: ensuring optimum delivery of the cascade of care for patients with tuberculosis (free PDF)

“My dream of placing all recent and still valid older WHO TB guidelines into a short compendium, to facilitate life of users, is now accomplished. With this booklet, one can access immediately all WHO standards of TB care”. (via @M_Raviglione see Tweet)

 

3 – #WorldTBDay (March 24, 2018) – The impact of social protection and poverty elimination on global tuberculosis incidence: a statistical modelling analysis of Sustainable Development Goal 1 – The Lancet Global Health (free)

Commentaries: Predicting the effect of improved socioeconomic health determinants on the tuberculosis epidemic – The Lancet Global Health (free) AND Eradicating poverty would dramatically reduce TB cases, study finds – The Guardian (free)

Ending extreme poverty and expanding social protection is estimated to reduce the incidence of tuberculosis by 84.3%.

 

4 – Guideline: Physical activity and the environment – National Institute for Health and Care Excellence (NICE) (free)

 

5 – Richard Smith: The dangers of textbooks – The BMJ Opinion (free)

Related: Authors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)

 

6 – The fraction of cancer attributable to modifiable risk factors in England, Wales, Scotland, Northern Ireland, and the United Kingdom in 2015 – British Journal of Cancer (free)

Commentaries: New calculations confirm lifestyle changes could prevent 4 in 10 cancer cases – Cancer Research UK (free) AND More than 2,500 cancer cases a week could be avoided – Cancer Research UK (free) AND Four in 10 cancer cases could be prevented by lifestyle changes – The Guardian (free)

 

7 – Vaccine waning and mumps re-emergence in the United States – Science Translational Medicine (link to abstract – $ for full-text)

Commentaries: Mumps resurgence likely due to waning vaccine-derived immunity – Harvard T.H. Chan School of Public Health (free) AND Mumps Vaccine Effectiveness Declines Over Time. But There’s A Solution – Forbes (free) AND Mumps Vaccine Protection Wanes Over Time, Study Finds – CommonHealth (free) AND Mumps Is On the Rise. A Waning Vaccine Response May Be Why – The New York Times (10 articles per month are free)

“a booster dose at age 18 should be a straight-forward solution to the problem based on models of how mumps spreads” (from Forbes)

 

8 – Facing the Shortage of IV Fluids — A Hospital-Based Oral Rehydration Strategy – New England Journal of Medicine (free)

Commentary: Boston Hospital May Have a Solution to IV Bag Shortage – Medscape (free registration required)

 

9 – Metabolic Slowing and Reduced Oxidative Damage with Sustained Caloric Restriction Support the Rate of Living and Oxidative Damage Theories of Aging – Cell Metabolism (free for a limited period)

Commentaries: Reduced-calorie diet shows signs of slowing ageing in people – Nature News (free) AND Will Cutting Calories Make You Live Longer? – Wired (free) AND Calorie restriction trial in humans suggests benefits for age-related disease – Cell Press, via ScienceDaily (free)

 

10 – Myocarditis in Patients Treated With Immune Checkpoint Inhibitors – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Myocarditis a Risk with Checkpoint Inhibitors – CRTOnline.org (free) AND Myocarditis in Patients Treated With Immune Checkpoint Inhibitors – American College of Cardiology, Latest in Cardiology (free)

Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

 


 

1 – Guideline: Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism – National Institute for Health and Care Excellence (NICE) (free)

 

2 – New Tool: Sustainable Development Goal (SDG) Tracker – Our World in Data (free)

Commentary: The U.N. Set 17 Goals To Make The World A Better Place. How’s It Doing? – NPR (free)

“The United Nations Sustainable Development Goals (SDGs) are targets for global development adopted in September 2015, set to be achieved by 2030. Here we present data across all available indicators from the Our World in Data database tracking progress towards these goals around the world”.

 

3 – When antibiotics turn toxic – Nature News (free)

“Commonly prescribed drugs called fluoroquinolones cause rare, disabling side effects. Researchers are struggling to work out why”.

 

4 – Associations of Monounsaturated Fatty Acids From Plant and Animal Sources With Total and Cardiovascular Mortality Risk – Circulation (link to abstract – presented at the American Heart Association’s Epidemiology and Prevention | Lifestyle and Cardiometabolic Health Scientific Sessions 2018)

Commentaries: Mono-unsaturated fats from plants, not animals may reduce risk of death from heart disease and other causes – AHA / ASA Newsroom (free) AND These plant-based fats could help you live longer – Medical News Today (free)

 

5 – Report: Violence and Mental Health: Opportunities for Prevention and Early Detection – National Academies Press (free PDF)

 

6 – A Randomized Trial of High-Flow Oxygen Therapy in Infants with Bronchiolitis – New England Journal of Medicine (free)

Commentaries: Efficacy of High-Flow O2 Tx Test Outside ICU for Infants With Bronchiolitis? – MPR (free) AND High-flow O2 therapy feasible for infants with bronchiolitis – MedicalXpress (free) AND High-Flow Oxygen Improves Infant Bronchiolitis Outcomes – MedPage Today (free)

 

7 – FDA In Brief: FDA updates public information about known risk of lymphoma from breast implants (free) AND Breast Implant-Associated Anaplastic Large Cell Lymphoma – FDA Update (free)

Commentaries: More Cases Are Reported of Unusual Cancer Linked to Breast Implants – The New York Times (10 articles per month are free) AND Implant-Related Lymphoma Cases Rise – More than 400 cases reported to FDA – MedPage Today (free)

Some 400 to 500 women worldwide have an unusual type of lymphoma linked to breast implants with textured surfaces. Experts say women considering implants should be told”. (via @NYTHealth see Tweet)

 

8 – Viewpoint: The Proposal to Lower P Value Thresholds to .005 – JAMA (free) (via @VinayPrasad82 see Tweet)

Related: What a nerdy debate about p-values shows about science — and how to fix it – VOX (free) AND Big names in statistics want to shake up much-maligned P value – Nature News (free) AND ‘One-size-fits-all’ threshold for P values under fire – Nature News (free) AND Statisticians issue warning over misuse of P values – Nature News (free) AND Understanding common misconceptions about p-values – The 20% Statistician (free) AND Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations – European Journal of Epidemiology(free)

 

9 – Effect of tai chi versus aerobic exercise for fibromyalgia: comparative effectiveness randomized controlled trial – The BMJ (free)

Commentaries: Time to rethink exercise for fibromyalgia care – The BMJ Opinion (free) AND The unintended consequences of tai chi for fibromyalgia – The BMJ Opinion (free) AND Tai chi may be as effective for fibromyalgia as standard exercise – NHS Choices (free) AND Tai chi at least as beneficial as aerobic exercise for fibromyalgia – OnMedica (free)

 

10 – Efficacy of a single-dose regimen of inactivated whole-cell oral cholera vaccine: results from 2 years of follow-up of a randomised trial – The Lancet Infectious Diseases (free)

Invited commentary: Cholera control: one dose at a time (free)

“Our results indicate that when such emergencies occur in populations with endemic cholera, the challenges of successfully completing a two-dose regimen should not deter deployment of OCV, because older children and adults will be protected for at least 2 years by a single dose”. (via @Onisillos see Tweet)

 


 

1 – Low Back Pain – New Series from The Lancet Journals

– Homepage and Executive Summary (free)

– Article 1: What low back pain is and why we need to pay attention (free registration required)

– Article 2: Prevention and treatment of low back pain: evidence, challenges, and promising directions (free registration required)

– Invited Commentary: Low back pain: a major global challenge (free registration required)

– Viewpoint: Low back pain: a call for action (free registration required)

Commentaries: Low Back Pain Affects 540 Million People Worldwide, but Too Many Patients Receive the Wrong Care – University of Warwick, via NewsWise (free) AND Lower back pain being treated badly on a global scale, study says – The Guardian (free)

 

2 – Education Outcomes in a Duty-Hour Flexibility Trial in Internal Medicine – New England Journal of Medicine (free)

Commentaries: Limiting shifts for medical trainees affects satisfaction, but not educational outcomes – MedicalXpress (free) AND Controversial Duty-Hours Trial Finds Difference in Intern Education – MedPage Today (free registration required) AND Limiting hours of resident shifts improves satisfaction—but not educational outcomes – Clinical Inovation + Technology (free)

 

3 – Helicobacter pylori Therapy for the Prevention of Metachronous Gastric Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: H. pylori Treatment for Gastric Cancer Prevention (free)

Commentary: H pylori Eradication Benefits Patients With Early Gastric Cancer – Medscape (free registration required)

 

4 – Behaviors, movements, and transmission of droplet-mediated respiratory diseases during transcontinental airline flights – Proceedings of the National Academy of Sciences (free)

Commentaries: Localized Risk for Infection Transmission on Planes, Study Finds – Medscape (free registration required) AND Researchers Determine Routes of Respiratory Infectious Disease Transmission on Aircraft – Georgia Tech News Center (free) AND Why you should choose your plane seat wisely – Medical News Today (free)

“Direct disease transmission outside of the one-meter area of an infected passenger is unlikely” (from Georgia Tech)

 

5 – Selected Articles from the Annual Update in Intensive Care and Emergency Medicine 2018 – BMC (free) (via @CritCareReviews)

 

6 – For hypertension and diabetes, lower treatment targets not necessarily better – American Family Physician Community Blog (free)

Related: AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline (free) AND ACC/AHA Hypertension Guideline: What Is New? What Do We Do? – American Family Physician (free) AND Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)

 

7 – Causes of death among children aged 5–14 years in the WHO European Region: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Child & Adolescent Health (free)

Invited commentary: Mortality in older children and adolescents: the forgotten ones (free)

Graphic 1: Top 25 causes of death in the WHO European Region, age 5–9 years, both sexes, 1990 and 2016 (free)

Graphic 2: Top 25 causes of death in the WHO European Region, age 10–14 years, both sexes, 1990 and 2016 (free)

 

8 – Time to Epinephrine Administration and Survival from Non-Shockable Out-of-Hospital Cardiac Arrest Among Children and Adults – Circulation (link to abstract – $ for full-text)

Commentary: Every Minute Counts with Epinephrine in Nonshockable Out-of-Hospital Cardiac Arrest – NEJM Journal Watch (free)

 

9 – Risk of maternal mortality in women with severe anaemia during pregnancy and post partum: a multilevel analysis – The Lancet Global Health (free)

Commentaries: Maternal anaemia and risk of mortality: a call for action – The Lancet Global Health (free) AND Risk of maternal death doubled in pregnant women with anemia – MedicalXpress (free)

 

10 – Socioeconomic disparities in first stroke incidence, quality of care, and survival: a nationwide registry-based cohort study of 44 million adults in England – The Lancet Public Health (free)

Invited commentary: Preventing stroke on the street where you live, work, and play (free)

Patients from the lowest socioeconomic groups had first stroke a median of 7 years earlier than those from the highest and a 26% higher adjusted risk of 1-year mortality.

 


 

1 – Screening for Skin Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Related Recommendation Statement: Behavioral Counseling to Prevent Skin Cancer: US Preventive Services Task Force (free)

JAMA Editorials:  Sun Protection and Skin Self-examination and the US Preventive Services Task Force Recommendation on Behavioral Counseling for Skin Cancer Prevention (free) AND Should Pediatricians Be More Proactive in Counseling Children About Skin Cancer Risk? Implications of the USPSTF Recommendation Statement (free) AND The Potential of Behavioral Counseling to Prevent Skin Cancer (free) AND USPSTF Recommendations for Behavioral Counseling for Skin Cancer Prevention: Throwing Shade on UV Radiation (free) AND The Value of Behavioral Counseling for Skin Cancer Prevention: Actions We Can Take Now and Guidance for the Future (free)

Author Interviews: Screening for Skin Cancer (free audio) AND USPSTF Recommendation: Behavioral Counseling to Prevent Skin Cancer (free)

Commentaries: Doctors endorse counseling of some kids, young adults to prevent skin cancer – Reuters (free) AND Evidence insufficient to make recommendation regarding visual skin examination by a clinician – The JAMA Network, via EurekAlert (free)

 

2 – Gender differences in the associations between age trends of social media interaction and well-being among 10-15 year olds in the UK – BMC Public Health (free)

Commentaries: Mental health risks to girls who spend more than an hour a day on social media – new study  – The Conversation (free) AND How much is too much? Does increasing use of social media having a damaging effect on young girls? – BMC Series Blog (free) AND Social Media May Be More Harmful To Girls Than Boys, Study Finds – Forbes (free)

See also a recent Pediatrics supplement: Children, Adolescents and Screens: What We Know and What We Need To Learn (free articles) and related texts on Social Media and Mental Health (free articles and commentaries)

 

3 – Are we prepared for the looming epidemic threat? – The Guardian (free) (via @Onisillos)

Related: The World Is Not Ready for the Next Pandemic – TIME cover story AND The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) AND Seven reasons we’re at more risk than ever of a global pandemic – CNN (free) AND Video: Pandemics – a worrying global public health threat (free)

 

4 – Cardiology World Erupts Into Controversy Over Change In Major Clinical Trial – Cardiobrief (free)

Related Article: Moving the Goalposts Into Unblinded Territory – Circulation: Cardiovascular Quality and Outcomes (free)

 

5 – Blood pressure-lowering treatment strategies based on cardiovascular risk versus blood pressure: A meta-analysis of individual participant data – PLOS Medicine (free)

Related study with similar conclusions: Impact of Cardiovascular Risk on the Relative Benefit and Harm of Intensive Treatment of Hypertension – Journal of the American College of Cardiology (link to abstract – $ for full-text)

“An intelligent approach towards blood pressure management: by the individual’s risk instead of just their measurements” (via @EricTopol see Tweet)

 

6 – Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors: data from the German CVSS-study – European Heart Journal (free)

Commentaries: Survivors of childhood cancer are at great risk of heart problems in adulthood – eCancerNews (free) AND Higher heart risk for survivors of childhood cancer – OnMedica (free)

Related study: The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE) – The Lancet (link to abstract – $ for full-text)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)

 

7 – Extensive impact of non-antibiotic drugs on human gut bacteria – Nature (link to abstract – $ for full-text)

Commentaries: The overlooked side effect of many drugs – Nature Microbiology Community (free) AND Study: Non-antibiotic drugs affect gut bacteria, could promote resistance – CIDRAP (free)

 

8 – Pulse oximetry for diagnosis of critical congenital heart defects – Cochrane Library (free)

Original article: Pulse oximetry screening for critical congenital heart defects – Cochrane Library (free)

Related study: Association of US State Implementation of Newborn Screening Policies for Critical Congenital Heart Disease With Early Infant Cardiac Deaths – JAMA (link to abstract – $ for full-text)

Related guidelines: Pulse oximetry screening for critical congenital heart defects: a European consensus statement – The Lancet Child & Adolescent Health (free) AND Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Position Statement on Pulse OximetryScreening in Newborns to Enhance Detection of Critical Congenital Heart Disease (free) AND Role of Pulse Oximetry in Examining Newborns for Congenital Heart Disease: A Scientific Statement from the AHA and AAP (free)

 

9 – European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) expert consensus on arrhythmias and cognitive function: what is the best practice? (free)

Commentary: New Expert Statement on Arrhythmias and Cognitive Function – Medscape (free registration required)

 

10 – Association of Inhaled Corticosteroids and Long-Acting β-Agonists as Controller and Quick Relief Therapy With Exacerbations and Symptom Control in Persistent Asthma: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

Related Meta-Analysis: Association of Inhaled Corticosteroids and Long-Acting Muscarinic Antagonists With Asthma Control in Patients With Uncontrolled, Persistent Asthma: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

Commentary: Reviews Reveal Benefits of LAMAs, LABAs, and SMART in Asthma – Medscape (free registration required)

 


 

1 – 2018 ESC Guidelines for the diagnosis and management of syncope – European Heart Journal (free for a limited period)

News release: European Society of Cardiology guidelines on syncope launched today at EHRA 2018 (free)

Related guideline: 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society (free)

 

2 – The 2018 European Heart Rhythm Association Practical Guide on the use of non-vitamin K antagonist oral anticoagulants in patients with atrial fibrillation – European Heart Journal (free for a limited period)

News release: New EHRA Practical Guide on non-vitamin K antagonist oral anticoagulants launched (free)

 

3 – MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis – New England Journal of Medicine (free)

Commentaries: Prostate MRI reveals more treatable cancers, reduces overdiagnosis than standard biopsy – European Urology Association, via EurekAlert (free) AND MRI Before Biopsy Better Than TRUS in Prostate Cancer – Medscape (free registration required)

 

4 – Direct-Acting Antiviral Prophylaxis in Kidney Transplantation From Hepatitis C Virus–Infected Donors to Noninfected Recipients: An Open-Label Nonrandomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: HCV Prophylaxis Could Expand Kidney Availability – Renal & Urology News (free) AND HCV-infected kidney donors could save lives – 2 Minute Medicine (free) AND One year posttransplant, recipients of hepatitis C kidneys disease-free – Johns Hopkins Medicine, ScienceDaily (free)

 

5 – Physical activity, sedentary behaviour and colorectal cancer risk in the UK Biobank – British Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Binge watching TV could increase bowel cancer risk in men – Imperial College London (free) AND Expert reaction to study on physical activity, sedentary behaviour and bowel cancer risk – Science Media Centre (free)

 

6 – Efficacy of Vaginal Estradiol or Vaginal Moisturizer vs Placebo for Treating Postmenopausal Vulvovaginal Symptoms: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Invited commentary: Rethinking the Approach to Managing Postmenopausal Vulvovaginal Symptoms (free for a limited period)

Author interview: Efficacy of Vaginal Estradiol or Moisturizer vs Placebo for Postmenopausal Vulvovaginal Symptoms (free)

Commentary: Vaginal Estradiol Offers Little Help for Postmenopausal Symptoms – Moisturizer no better than placebo gel, either – MedPage Today (free registration required)

 

7 – MMWR Report: Fatal Yellow Fever in Travelers to Brazil, 2018 – Centers for Disease Control and Prevention (CDC) (free)

Commentaries: Thinking of Going to Brazil? You Will Need a Yellow Fever Vaccination – The New York Times (free) AND Brazil’s yellow fever outbreak, explained – VOX (free)

 

8 – Richard Lehman’s journal review, 19 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Are shorter courses of systemic steroids as effective as conventional longer courses in the treatment of patients with flare-ups of COPD? – Cochrane Library (free)

“Information from a new large study has increased our confidence that five days of oral corticosteroids is likely to be sufficient for treatment of adults with acute exacerbations of COPD”.

 

10 – Suicide After Deliberate Self-Harm in Adolescents and Young Adults – Pediatrics (free)

Commentary: Young People Who Self-Harm Face Striking Increase in Suicide Risk – Physician’s First Watch (free)

Teens who self-harm are nearly 50 times more likely to commit suicide in the next year compared with their non-self-harming peers” (via @Physns1stWatch see Tweet)

 


 

1 – The impact of confounding on the associations of different adiposity measures with the incidence of cardiovascular disease: a cohort study of 296 535 adults of white European descent – European Heart Journal (free)

Commentaries: New study casts further doubt on the idea that you can be ‘fat and fit’ – NHS Choices (free) AND A ‘Sweet Spot’ for Heart Health – The New York Times (10 articles per month are free) AND A ‘sweet spot’ BMI to reduce heart disease risk? What you need to know – HealthNewsReview (free)

 

2 – Clinical Guideline Synopsis: Evaluation and Treatment of Male Hypogonadism – JAMA (free)

Original Guideline: Testosterone Therapy in Men With Hypogonadism: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free PDF)

Commentary: New Testosterone Treatment Guidelines ‘Useful but Not Gospel’ – Medscape (free registration required)

 

3 – Free Online Course (small fee if applying for certificate). Starts March 26, 2018. The Sustainable Development Goals – A global, transdisciplinary vision for the future – University of Copenhagen and Coursera

 

4 – New Series from The Lancet Journals: Pathology and laboratory medicine in low-income and middle-income countries (free registration required for all articles and commentaries)

 

5 – Preventing physician suicide – ACP Hospitalist (free)

Related: What I’ve learned from my tally of 757 doctor suicides – The Washington Post (free) AND Why are doctors killing themselves? – MJA InSight (free) AND Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT (free) AND Protecting interns and other physicians from depression and suicide – STAT (free)

 

6 – The DiPEP (Diagnosis of PE in Pregnancy) biomarker study: An observational cohort study augmented with additional cases to determine the diagnostic utility of biomarkers for suspected venous thromboembolism during pregnancy and puerperium – British Journal of Haematology (free)

Commentary: Imaging is the only way to diagnose blood clots in pregnancy – NIHR Signal (free)

No blood test can accurately tell if a pregnant or recently pregnant woman has a blood clot. All pregnant women with a suspected clot should continue to have imaging investigations” (via @NIHR_DC  see Tweet)

 

7 – Tracheotomy in the intensive care unit: guidelines from a French expert panel – Annals of Intensive Care (free)

 

8 – Older Abuse: Sometimes It’s Self-Inflicted – The New York Times (10 articles per month are free)

The house is filthy. The elderly resident is struggling. But who has the right to intervene?” (via @NYTHealth see Tweet)

 

9 – Diastolic Blood Pressure and Adverse Outcomes in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist) Trial – Journal of the American Heart Association (free for a limited period)

“DBP values ≥90 and <60 mm Hg are associated with a significant risk of adverse outcomes in patients with heart failure with preserved ejection fraction who are treated for hypertension”.

 

10 – Oral vitamin B12 compared with intramuscular vitamin B12 for vitamin B12 deficiency – Cochrane Library (free)

Commentary: Oral vs. Intramuscular Vitamin B12: Efficacy, Safety Compared – MPR (free)

 


 

1 – Mapping child growth failure in Africa between 2000 and 2015 – Nature (free)

Invited commentary, by Kofi Annan: Data can help to end malnutrition across Africa (free)

Other commentaries: Africa ‘very, very far away’ from meeting global target to end child malnutrition – The Guardian (free) Local Burden of Disease – Child Growth Failure – IHME (free) AND Zooming in on advances and opportunities – IHME (free)

 

2 – Guideline: Attention deficit hyperactivity disorder: diagnosis and management – National Institute for Health and Care Excellence (NICE) (free)

 

3 – State of The Art Review: Pulmonary arterial hypertension: pathogenesis and clinical management – The BMJ (free for a limited period)

Related Guidelines: Pharmacologic Therapy for Pulmonary Arterial Hypertension in Adults – CHEST Guideline and Expert Panel Report (free) AND 2015 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension (free)

 

4 – Very interesting resource: A Visual introduction to the basic concepts of probability theory – Seeing Theory (free) (via @CochraneUK see Tweet)

 

5 – Midlife cardiovascular fitness and dementia: A 44-year longitudinal population study in women – Neurology (free)

Commentaries: High Cardiovascular Fitness in Midlife Tied to Lower Dementia Risk Later – NEJM Physician’s First Watch (free) AND Physically fit women nearly 90 percent less likely to develop dementia – American Academy of Neurology, via ScienceDaily (free)

 

6 – Like It Or Not, Personal Health Technology Is Getting Smarter – NPR (free)

“Nice article about wearables related issues, such as medicalization of the healthy, privacy loss, low adherence, uncertain reliability of measurements and uncertain health benefits”. (via @RasoiniR see Tweet)

 

7 – Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? – HealthNewsReview (free)

Related: Get Ready For A Tsunami Of ECGs – Cardiobrief (free) AND: Thoughts on the Apple Watch and Mobile ECG, by Dr John Mandrola (free) AND Overdiagnosis Only a Matter of Time With ECG Watches – Medscape (free registration required)

 

8 – Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free)

 

9 – Statement: American Diabetes Association® Deeply Concerned About New Guidance from American College of Physicians Regarding Blood Glucose Targets for People with Type 2 Diabetes (free)

See original guideline and commentary: ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes

 

10 – Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial – Gut (link to abstract – $ for full-text)

Commentaries: Calcium and vitamin D supplements may raise risk of polyps – MedicalNewsToday (free) AND Calcium Supplements Up Risk for Precancerous Serrated Polyps – Medscape (free registration required)

See related meta-analysis of RCT showing calcium and vitamin D don’t prevent bone fractures

 


 

1 – Pregnancy Outcomes after ZIKV Infection in French Territories in the Americas – New England Journal of Medicine (free)

Editorial: Recognizing the Global Impact of Zika Virus Infection during Pregnancy (free)

Quick Take Video Summary: Pregnancy Outcomes after Zika (free)

Commentaries: Study: 7% risk of birth defects in Zika pregnancies – CIDRAP (free) AND Birth defect rate pegged at 7 percent for babies born to Zika-infected women – Reuters (free)

 

2 – Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa – New England Journal of Medicine (free)

Commentary: Combo Tx Offers New Hope for Cryptococcal Meningitis – MedPage Today (free registration required)

 

3 – Management of Multi-Casualty Incidents in Mountain Rescue: Evidence-Based Guidelines of the International Commission for Mountain Emergency Medicine (ICAR MEDCOM) (free)

Source: Critical Care Reviews Newsletter

 

4 – Grader Variability and the Importance of Reference Standards for Evaluating Machine Learning Models for Diabetic Retinopathy – Ophthalmology (link to abstract – $ for full-text)

Commentary: Google’s AI program: Building better algorithms for detecting eye disease – ScienceDaily (free)

 

5 – Editorial: AI diagnostics need attention – Nature (free) (via @RasoiniR see Tweet)

 

6 – #ACC18 – More Deaths, Strokes Seen with Perioperative Beta Blocker One Year After Surgery – American College of Cardiology (free)

Related systematic review (just published): Perioperative beta-blockers for preventing surgery-related mortality and morbidity – Cochrane Library (free)

 

7 – #ACC18 – Cardiovascular Safety of Febuxostat or Allopurinol in Patients with Gout – New England Journal of Medicine (free)

Commentaries: Gout Drug Febuxostat Linked to More CV Deaths Without Uptick in CV Events: CARES Trial – TCTMD (free) AND CARES: Increased Risk of Death With Febuxostat in Patients With Gout and CV Disease – American College of Cardiology (free)

 

8 – Colonoscopy and Colorectal Cancer Mortality in the Veterans Affairs Health Care System: A Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Colonoscopy significantly reduces mortality from colorectal cancer in Veterans Affairs study – 2 Minute Medicine (free) AND Colonoscopy Significantly Reduces CRC Deaths – Medscape (free registration required)

 

9 – N-Terminal Pro–B-Type Natriuretic Peptide in the Emergency Department – Journal of the Americana College of Cardiology (link to abstract – $ for full-text)

Commentary: NT-proBNP cutpoints validated for diagnosing and ruling out heart failure in the ED – ACP Hospitalist (free)

Related review: BNP in the emergency department: The evidence – First10EM (free)

“In acutely dyspneic patients seen in the ED setting, age-stratified NT-proBNP cutpoints may aid in the diagnosis of acute HF. An NT-proBNP <300 pg/ml strongly excludes the presence of acute HF”.

 

10 – Sustained Physical Activity, Not Weight Loss, Associated With Improved Survival in Coronary Heart Disease – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: For CHD Patients, Physical Activity More Meaningful Than Weight Changes Over Time – TCTMD (free)

 


 

1 – Endovascular treatment for acute ischaemic stroke in routine clinical practice: prospective, observational cohort study (MR CLEAN Registry) – The BMJ (free)

Related guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association / American Stroke Association (free PDF) AND Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)

“In routine clinical practice, endovascular treatment for patients with acute ischemic stroke is at least as effective and safe as in the setting of a randomized controlled trial”.

 

2 – Editorial: Dialysis Modality Survival Comparison: Time to End the Debate, It’s a Tie – American Journal of Kidney Diseases (free)

Related commentary: PD or HD: Which Road Do We Take? – AJKD Blog (free)

Original article: Comparison of Patient Survival Between Hemodialysis and Peritoneal Dialysis Among Patients Eligible for Both Modalities – American Journal of Kidney Diseases (link to abstract – $ for full-text)

Source: Hemodialysis vs. Peritoneal Dialysis for End-Stage Renal Disease – NEJM Journal Watch ($)

 

3 – Low-level lead exposure and mortality in US adults: a population-based cohort study – The Lancet Public Health (free)

Commentaries: Lead and the heart: an ancient metal’s contribution to modern disease – The Lancet Public Health (free) AND Lead exposure may be linked to 412,000 premature US deaths yearly, study says – The Guardian (free) AND Lead and CDV deaths in US adults – Science Media Centre (free) AND Expert reaction to lead and CVD deaths in the US – Science Media Centre (free)

 

4 – Health Care Spending in the United States and Other High-Income Countries – JAMA (free article, editorials, author interview and video summary)

Commentaries: Why Is U.S. Health Care So Expensive? Some of the Reasons You’ve Heard Turn Out to Be Myths – The New York Times (10 articles per month are free) AND Huge cost of US healthcare driven by drug prices and salaries – The Guardian (free) AND Healthcare: It’s The Prices, Stupid. Isn’t It? – Forbes (free) AND Physician Salaries, Drug Prices Drive High US Health Costs – Medscape (free registration required)

 

5 – Digital Rectal Examination for Prostate Cancer Screening in Primary Care: A Systematic Review and Meta-Analysis – Annals of Family Medicine (free)

Commentaries: New analysis recommends against using digital rectal exam in primary care – American Academy of Family Physicians, vie EurekAlert (free) AND Little Evidence Supports Use of Digital Rectal Exam – Medscape (free registration required) AND Digital Rectal Exams for Routine Prostate Screening Discouraged – NEJM Physician’s First Watch (free)

 

6 – Korean Clinical Practice Guidelines for Aneurysmal Subarachnoid Hemorrhage – Journal of Korean Neurosurgical Society (free)

 

7 – Did a pricey cholesterol-lowering drug really reduce deaths, as headlines claim? – Health News Review (free)

See original article and commentaries in our March 12th issue (see #2)

 

8 – Effects of stress on the development and progression of cardiovascular disease – Nature Reviews Cardiology (free PDF for a limited period) (via @Abraham_RMI)

  

9 – Chronic kidney disease and arrhythmias: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference – European Heart Journal (free)

 

10 – The 2017 ESC Guidelines on PADs: what’s new? – European Heart Journal (free) AND The ‘Ten Commandments’ of 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases – European Heart Journal (free)

Original Guideline: 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS) (free)

 


 

1 – Evaluation and Treatment of Hirsutism in Premenopausal Women: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free)

Key Points: Evaluation and Treatment of Hirsutism in Premenopausal Women – JAMA Clinical Guidelines Synopsis (free for a limited period)

 

2 – #ACC18 – Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops – New England Journal of Medicine (free for a limited period)

Commentaries: Barbershop-Based Intervention Leads to Blood Pressure Reductions in African-American Men – American College of Cardiology (free) AND Mixing Haircuts and Hypertension Rx a ‘Home Run’ for Blood Pressure Control – TCTMD (free)

Among black male barbershop patrons with uncontrolled hypertension, health promotion by barbers resulted in larger blood-pressure reduction when coupled with medication management in barbershops by specialty-trained pharmacists”.

 

3 – #ACC18 – 6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (SMART-DATE): a randomised, open-label, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentaries: SMART-DATE: Myocardial Infarction Risk Higher with Six-Month Versus Twelve-Month DAPT – American College of Cardiology (free) AND Too Soon for 6-Month DAPT, Say SMART-DATE Investigators, Despite Positive Trial – TCTMD (free)

Related Guidelines: 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free) AND 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)

 

4 – #ACC18 – Low-Dose ‘Triple Pill’ Lowers Blood Pressure More Than Usual Care – American College of Cardiology (free) AND Low-Dose, Three-Drug Polypill TRIUMPHs for Blood Pressure – TCTMD (free)

 

5 – Viewpoint: Big Data and Machine Learning in Health Care – JAMA (free for a limited period)

 

6 – Aromatherapy Versus Oral Ondansetron for Antiemetic Therapy Among Adult Emergency Department Patients: A Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentaries: Practice Changing: Inhaled Isopropyl Alcohol Superior to Oral Ondansetron as an Antiemetic – NEJM Journal Watch (free) AND Wake Up And Smell the Isopropyl – Emergency Medicine Literature of Note (free)

 

7 – Do Antidepressants Work? – The New York Times (10 articles per month are free)

“The most comprehensive study on them has recently been published, showing mostly modest effects”.

See related meta-analysis and commentaries in our February 23rd issue (see #3)

 

8 – Richard Lehman’s journal reviews, 12 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Plasma 25-hydroxyvitamin D concentration and subsequent risk of total and site specific cancers in Japanese population: large case-cohort study within Japan Public Health Center-based Prospective Study cohort – The BMJ (free)

“Wake me up when there is a positive randomized trial of vitamin D pills for anything” (from Richard Lehman’s review, see above).

 

10 – Risk of stroke in patients with dengue fever: a population-based cohort study – Canadian Medical Association Journal (free)

Commentary: Dengue fever linked to increased risk of stroke – CMAJ, via ScienceDaily (free)

 


 

#ACC18 – Highlights from the American College of Cardiology’s 67th Annual Scientific Session

 

1 – Acute Myocardial Infarction Mortality During Dates of National Interventional Cardiology Meetings – Journal of the American Heart Association (free)

Commentaries: Survival benefit seen for some patients when cardiologists are away at academic conferences – Harvard Medical School, via ScienceDaily (free) AND TCT paradox: Patients more likely to survive MI during interventional cardiology conference – Cardiovascular Business (free)

Related study: Mortality and Treatment Patterns Among Patients Hospitalized With Acute Cardiovascular Conditions During Dates of National Cardiology Meetings – JAMA Internal Medicine (free)

“The study’s release date is particularly timely considering another major conference—the American College of Cardiology’s Scientific Session—kicks off this weekend”. (from Cardiovascular Business)

 

2 – #ACC18 – The ODYSSEY Trial Ends Well— But Will It Be Enough? – Cardiobrief (free) AND Ten Quick Thoughts on ODYSSEY – John Mandrola, via Medscape (free registration required)

“An absolute risk reduction of 1.6% in the primary endpoint translates to a number needed to treat of 64. Using the current price of $14,500 per year, Kaul calculated that preventing one event over the trial period of almost 3 years would cost about $2.6 million” (via John Mandrola). This study was presented at #ACC18 and has not been published yet. Among the many commentaries, these two were selected for a balanced point of view.

 

3 – #ACC18 – Carvedilol for Prevention of Chemotherapy Related Cardiotoxicity – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Beta Blocker Shows Mixed Results in Protecting Against Chemo-Induced Heart Damage – American College of Cardiology (free) AND Carvedilol Effect in Preventing Chemotherapy Induced CardiotoxicitY – CECCY – American College of Cardiology (free)

Related study from #ACC18: Heart Drugs Prevented Cardiotoxicity in Breast Cancer Treated With Anthracycline and Trastuzumab – American College of Cardiology (free)

“According to the CECCY trial, carvedilol had no effect on left ventricular function in breast cancer patients treated w/ doxorubicin, but did result in a reduction in troponin I levels & diastolic dysfunction”. (via @ACCinTouch see Tweet)

 

4 – #ACC18 – Effect of Loading Dose of Atorvastatin Prior to Planned Percutaneous Coronary Intervention on Major Adverse Cardiovascular Events in Acute Coronary Syndrome: The SECURE-PCI Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Lipid Lowering in Acute Coronary Syndrome: Is Treatment Early Enough? (free for a limited period)

Commentaries: Statins Evaluation in Coronary Procedures and Revascularization – SECURE-PCI – American College of Cardiology (free) AND No Benefits Likely with Very Early Statins in ACS Patients – MedPage Today (free registration required) AND SECURE-PCI Comes Up Short for Statin Preloading in ACS Patients – TCTMD (free)

 

5 – #ACC18 – Hospital Readmission After Perioperative Acute Myocardial Infarction Associated With Noncardiac Surgery – Circulation (free PDF for a limited period)

Commentaries: Hospital Readmissions After Perioperative AMI – American College of Cardiology, Latest in Cardiology (free) AND Perioperative MIs Bring Too Many Patients Back to the Hospital After Noncardiac Surgery – TCTMD (free)

 

6 – #ACC18 – Big Swings in Daily Temperatures Linked to Spikes in MI Rates – TCTMD (free) AND Heart Attacks Often Follow Extreme Temperature Changes – Cardiosmart (free) AND Outdoor Temperature Swings Tied to STEMI Uptick – Medscape (free registration required) AND Dramatic swings in temperature linked to significantly more heart attacks – News Medical (free)

 

7 – #ACC18 – Inflammatory Bowel Disease Increases Likelihood of a Heart Attack – American College of Cardiology (free) AND Inflammatory bowel disease may raise heart attack risk – Medical News Today (free) AND Those with IBD twice as likely to have heart attack – Cardiovascular Business (free) AND Inflammatory Bowel Disease Makes Heart Attack Twice as Likely – Cardiosmart (free)

 

8 – #ACC18 – Getting flu shot halves death risk for heart failure patients – Cardiovascular Business (free) AND Flu Vaccine Reduces Mortality, Hospitalization in HF Patients: Meta-analysis – TCTMD (free) AND Flu Shot Cuts Risk for Death by Half in Heart Failure – Medscape (free registration required) AND Getting Flu Vaccine Cuts Risk of Death by Half in People with Heart Failure – American College of Cardiology (free)

This meta-analysis of observational studies suggests a possible benefit.

 

9 – #ACC18 – Aspirin Lowers Risk of Death for Patients with Diabetes, Heart Failure – American College of Cardiology (free) AND Aspirin Linked to Lower Mortality in Diabetes With Heart Failure – Medscape (free registration required) AND ACC 2018: Aspirin Lowers Risk of Death in Patients With Diabetes and Heart Failure – PracticeUpdate (free registration required)

 

10 – #ACC18 – MANAGE: Reduced Mortality and Cardiovascular Events in MINS Patients Receiving Dabigatran – American College of Cardiology (free) AND MANAGE Suggests Dabigatran Could Be Useful for Treating Myocardial Injury After Noncardiac Surgery – TCTMD (free)

“One expert called the trial results “provocative” but said its methods were “muddy,” making the findings difficult to interpret” (from TCTMD)

 


 

1 – The Tobacco Atlas, Sixth Edition (free PDF)

News Release: Big tobacco is targeting the world’s most vulnerable to increase profits – American Cancer Society (free)

See companion website: TobaccoAtlas.org

Related: Explore the GBD tool to compare tobacco risks globally – IHME (free interactive tool)

 

2 – European Society of Cardiology, acute cardiovascular care association, SCAD study group: a position paper on spontaneous coronary artery dissection – European Journal of Cardiology (free)

Commentary with key points to remember: European Position Paper on Spontaneous Coronary Artery Dissection – American College of Cardiology, Latest in Cardiology (free)

Related position statement: Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association – Circulation (free)

 

3 – Fluoroquinolone use and risk of aortic aneurysm and dissection: nationwide cohort study – The BMJ (free)

Related: Aortic Dissection and Aortic Aneurysms Associated with Fluoroquinolones: A Systematic Review and Meta-Analysis – American Journal of Medicine (free) AND Fluoroquinolones and collagen associated severe adverse events: a longitudinal cohort study – BMJ Open (free) AND Risk of Aortic Dissection and Aortic Aneurysm in Patients Taking Oral Fluoroquinolone – JAMA Internal Medicine (free)

 

4 – Graduate students need more mental health support, new study highlights – Science (free) AND Mental Health Crisis for Grad Students – Inside Higher Ed (free) AND Depression, anxiety high in graduate students, survey shows – University of Texas Health Science Center, via ScienceDaily (free)

 

5 – Case report: Self-Management of an Inferior ST-Segment Elevation Myocardial Infarction – New England Journal of Medicine (free)

 

6 – Maintenance proton pump inhibition therapy and risk of oesophageal cancer – Cancer Epidemiology (link to abstract – $ for full-text)

Commentary: Long-term PPI Use and Increased Esophageal CA Risk – Medscape (free registration required)

Related studies suggesting a link with gastric cancer: Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study – Gut (link to abstract – $ for full-text) AND Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden – BMJ Open (free)

This observational study suggests a possible link.

 

7 – Metformin use in PCOS pregnancies increases the risk of offspring overweight at 4 years of age; follow-up of two RCTs – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)

Commentaries: Diabetes drug use during pregnancy linked to child’s weight – The Endocrine Society, via ScienceDaily (free) AND Diabetes drug use during pregnancy affects child’s weight – OnMedica (free) AND Metformin in Pregnancy May Increase Childhood Obesity Risk – Medscape (free registration required)

 

8 – EVOLVE: The Australian Rheumatology Association’s ‘top five’ list of investigations and interventions doctors and patients should question – Internal Medicine Journal (free) (via @RSiemieniuk)

See other lists of low-value practices in Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

Another interesting list of commonly used low-value practices that should be questioned.

 

9 – Inflammatory Bowel Disease Increases Likelihood of a Heart Attack – American College of Cardiology (free) AND Inflammatory bowel disease may raise heart attack risk – Medical News Today (free) AND Those with IBD twice as likely to have heart attack – Cardiovascular Business (free)

 

10 – Diet during pregnancy and infancy and risk of allergic or autoimmune disease: A systematic review and meta-analysis – PLOS Medicine (free)

Commentary: Probiotics and fish oil in pregnancy may reduce allergies in children – NHS Choices (free) AND Diet During Pregnancy May Cut Offspring Allergy Risk – MedPage Today (free registration required) AND Probiotics and Fish Oil During Pregnancy May Curb Allergies in Kids – The New York Times (10 articles per month are free)

 


 

1 – Association Between Estimated Cumulative Vaccine Antigen Exposure Through the First 23 Months of Life and Non–Vaccine-Targeted Infections From 24 Through 47 Months of Age – JAMA (link to abstract – $ for full-text)

Commentaries: Vaccines won’t overload your child’s immune system—or increase their risk of other infections – Science (free) AND Too Many Too Soon? No! – Science-Based Medicine (free) AND Study finds no immune overload for US kids’ vaccine schedule – CIDRAP (free)

 

2 – Frequency and level of evidence used in recommendations by the National Comprehensive Cancer Network guidelines beyond approvals of the US Food and Drug Administration: retrospective observational study – The BMJ (free)

Commentaries: Vinay Prasad on the NCCN’s cancer treatment guidelines: The US system needs an audit – The BMJ Opinion (free) AND US cancer network recommending expensive drugs based on weak evidence, study finds – The Guardian (free) AND New Study Questions Evidence for NCCN Recommendations – Medscape (free registration required)

 

3 – Digoxin and Mortality in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Digoxin and Mortality in Patients With Atrial Fibrillation – American College of Cardiology, Latest in Cardiology (free) AND Digoxin Associated with Higher Mortality in Patients with Atrial Fibrillation – NEJM Physician’s First Watch (free)

 

4 – Effect of β‐Blockers Beyond 3 Years After Acute Myocardial Infarction – Journal of the American Heart Association (free for a limited period)

Related article: B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)

 

5 – Cancer screening recommendations: an international comparison of high income countries – Public Health Reviews (free) (via @hildabast see Tweet)

 

6 – Fluid therapy in neurointensive care patients: ESICM consensus and clinical practice recommendations – Intensive Care Medicine (free for a limited period) (via @luiscamacho02)

 

7 – Factor Xa inhibitors versus vitamin K antagonists for preventing cerebral or systemic embolism in patients with atrial fibrillation – Cochrane Library (free)

Summary: Comparing two types of blood-thinning drugs, factor Xa inhibitors and vitamin K antagonists, to prevent blood clots in people with atrial fibrillation – Cochrane Library (free)

When available, Factor Xa inhibitors seem to be a better choice for treating these patients.

 

8 – The Science of Obesity Management: An Endocrine Society Scientific Statement – Endocrine Reviews (free)

Commentary: Research Finds Little Difference Among Diet Plans’ Long-Term Effectiveness – Endocrine Society, via NewWise (free)

  

9 – Cough Due to TB and Other Chronic Infections – CHEST Guideline and Expert Panel Report (free)

See also other recent CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)

 

10 – Effect of Offering Same-Day ART vs Usual Health Facility Referral During Home-Based HIV Testing on Linkage to Care and Viral Suppression Among Adults With HIV in Lesotho: The CASCADE Randomized Clinical Trial – JAMA (free)

Editorial: The Global HIV Epidemic: What Will It Take to Get to the Finish Line? (free)

Commentary: HIV in sub-Sahara Africa: Testing and treatment start at home improves therapy – Swiss Tropical and Public Health Institute, via EurekAlert (free)

Related: Starting antiretroviral therapy immediately after HIV diagnosis reduces transmission of the virus – NIHR Signal (free)

 


 

1 – Effect of Opioid vs Nonopioid Medications on Pain-Related Function in Patients With Chronic Back Pain or Hip or Knee Osteoarthritis Pain: The SPACE Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Opioids Don’t Beat Other Medications For Chronic Pain – NPR (free) AND More Data Opioids No Better for Chronic Back, Arthritis Pain – Medscape (free registration required) AND Opioids no better than NSAIDs for chronic back or arthritis pain – Reuters (free)

Related: Opioid Wisely – Choosing Wisely Canada (free) AND Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free) 

 

2 – Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: One-off PSA screening for prostate cancer does not save lives – eCancer News (free)

“Largest ever prostate cancer trial – CAP – published in the JAMA. No effect from low intensity PSA screening on prostate cancer mortality at 10 years”. (via @KariTikkinen see Tweet)

 

3 – Authors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)

‘The most recognized book in all of medicine’ is also rife with hidden financial conflicts. Should Harrison’s authors be disclosing $11 million in payments from drug and device makers?” (via @caseymross see Tweet)

 

4 – One-Month Tuberculosis Prophylaxis as Effective as Nine-Month Regimen for People Living with HIV – National Institute of Allergy and Infectious Diseases (free) (via @iasociety see Tweet)

Related: New ways to fight HIV and tuberculosis emerge at AIDS conference – Science (free)

 

5 – Scandinavian SSAI clinical practice guideline on choice of inotropic agent for patients with acute circulatory failure – Anaesthesiologica Scandinavica (free)

Source: Critical Care Reviews Newsletter

 

6 – Why Apple, Amazon, and Google are making big health care moves – VOX (free)

 

7 – Opinion: Are Hospitals Becoming Obsolete? – The New York Times (10 articles per month are free)

 

8 – Big Swings in Daily Temperatures Linked to Spikes in MI Rates – TCTMD (free)

 

9 – Frailty and the management of patients with acute cardiovascular disease: A position paper from the Acute Cardiovascular Care Association – European Heart Journal: Acute Cardiovascular Care (free)

 

10 – Antithrombotic therapy and body mass: an expert position paper of the ESC Working Group on Thrombosis – European Heart Journal (free)

 


 

1 – Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)

Commentary: Major Medical Associations Feud Over Diabetes Guidelines – NPR (free)

“Clinicians should aim to achieve an HbA1c level between 7% and 8% in most patients with type 2 diabetes”

 

2 – Treatment of infections caused by multidrug-resistant Gram-negative bacteria: report of the British Society for Antimicrobial Chemotherapy/Healthcare Infection Society/British Infection Association Joint Working Party – Journal of Antimicrobial Chemotherapy (free) (via @ABsteward)

 

3 – Highlights of the 2017 European AIDS Clinical Society (EACS) Guidelines for the treatment of adult HIV-positive persons version 9.0 (free)

See original EACS Guidelines in 7 languages (all free)

 

4 – Management of opioid use disorders: a national clinical practice guideline – Canadian Medical Association Journal (free) (via @DavidJuurlink see Tweet)

 

5 – Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)

Editorial: Pharmacological strategies in heart failure with preserved ejection fraction: time for an individualised treatment strategy? (free)

Commentary: Heartbeat: Is there any effective therapy for heart failure with preserved ejection fraction? (free)

In this meta-analysis of RCT testing treatments for patients with heart failure with preserved ejection fraction, only beta-blockers demonstrated reductions in all-cause and cardiovascular mortality.

 

6 – Relation of Dietary Sodium (Salt) to Blood Pressure and Its Possible Modulation by Other Dietary Factors: The INTERMAP Study – Hypertension (link to abstract – $ for full-text)

Commentaries: Healthy diet may not offset high salt intake – Imperial College London (free) AND Dietary sodium’s impact may not be offset by other aspects of a diet – AHA / ASA Newsroom (free)

 

7 – Richard Lehman’s journal review, 5 March 2018 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Too Late To Operate? Surgery Near End Of Life Is Common, Costly – NPR (free)

 

9 – Summary for ED-relevant care: 2018 AHA/ASA Ischemic Stroke Updates – emDocs (free)

Original guideline: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association (free PDF)

 

10 – Outcomes, experiences and palliative care in major stroke: a multicentre, mixed-method, longitudinal study – Canadian Medical Association Journal (free)

““Palliative care” had connotations of treatment withdrawal and imminent death… practicing the principles of palliative care is needed, but the term “palliative care” should be avoided or reframed”.

See related articles on this subject: Palliative care: renaming as supportive care and integration into comprehensive cancer care – CMAJ (free) AND Perceptions of palliative care among patients with advanced cancer and their caregivers (free)

 


 

1 – Guidelines for the diagnosis, prevention and management of cryptococcal disease in HIV-infected adults, adolescents and children – World Health Organization (free)

See also: Key Messages AND Policy Brief (free PDF)

 

2 – Novel subgroups of adult-onset diabetes and their association with outcomes: a data-driven cluster analysis of six variables – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: 5 Classifications of Diabetes Proposed – Physician’s First Watch (free) AND Should diabetes be divided into 5 categories to improve treatment? – Cardiovascular Business (free) AND Diabetes Consists of Five Types, Not Two, Say Researchers – Medscape (free registration required)

 

3 – New Guide to Infection Control in The Hospital – International Society for Infectious Diseases (free)

A free, online resource on the principles and interventions needed to reduce healthcare associated infections, with suggested control measures across different resource levels.

 

4 – Clinical Practice Guideline: Hoarseness (Dysphonia) – American Academy of Otolaryngology—Head and Neck Surgery (free)

See also: Executive Summary

 

5 – Opioid Wisely – Choosing Wisely Canada (free)

Related Guideline: Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free) 

See complete lists from Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

This campaign encourages thoughtful conversation between clinicians and patients to reduce harms associated with opioid prescribing, with recommendations relevant to different specialties.

 

6 – New campaign: Nursing Now campaign: empowering nurses to improve global health – World Health Organization (free)

Related: Global nursing movement launches – Devex (free) AND Nursing Now campaign: raising the status of nurses – The Lancet (free registration required)

See also: Nursing Now Website

Source: International Health Policies Newsletter

 

7 – Effectiveness of brief alcohol interventions in primary care populations – Cochrane Library (free)

In general practice or emergency care settings, brief alcohol interventions can reduce alcohol consumption and related harm.

 

8 – The Challenge of Doctor-Patient Relations in the Internet Age – The New York Times (10 articles per month are free)

Related: E-patients hold key to the future of healthcare – The BMJ Opinion (free)

 

9 – Editorial: Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations (free)

Trial 1: Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations – The New England Journal of Medicine (free)

Trial 2: Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations – The New England Journal of Medicine (free)

 

10 – Nut Consumption and Survival in Patients With Stage III Colon Cancer: Results From CALGB 89803 (Alliance) – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentaries: Nut Consumption May Aid Colon Cancer Survival – Yale Cancer Center, via NewsWise (free) AND Nuts, Especially Tree Nuts, and Improved CRC Survival – Medscape (free registration required

A survival benefit was suggested by this observational trial.

 


 

1 – Hydrocortisone plus Fludrocortisone for Adults with Septic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Hydrocortisone-fludrocortisone cuts deaths in septic shock – The Hospitalist (free)

See related research and commentaries on adjunctive glucocorticoid therapy in patients with septic shock

 

2 – Policy Statement: Pediatric Medication Safety in the Emergency Department – American Academy of Pediatrics (free)

Commentaries: Recommendations Issued on Reducing Pediatric Medication Errors in the ED – NEJM Physician’s First Watch (free) AND Policy statement outlines ways to improve pediatric medication safety – 2 Minute Medicine (free)

 

3 – Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data – The Lancet (link to abstract – $ for full-text)

This meta-analysis of randomized trials showed CABG had a mortality benefit over PCI in patients with multivessel disease, particularly those with diabetes and higher coronary complexity. There was no mortality benefit in patients with left main disease.

 

4 – Meta-analysis: Long-Term Outcomes of On- Versus Off-Pump Coronary Artery Bypass Grafting – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Long-Term Outcomes of On- vs. Off-Pump CABG – American College of Cardiology, Latest in Cardiology (free) AND Long-term survival benefit seen in on-pump vs off-pump CABG – Cardiovascular Business (free)

“Off pump CABG. probably best used in a limited set of patients…” (via @keaglemd see Tweet)

 

5 – Public Health: Tackling multiple unhealthy risk factors: Emerging lessons from practice – The King’s Fund (free PDF)

Commentary: Multiple unhealthy risk factors: why they matter and how practice is changing (free)

See also: Summary (free PDF) AND  Overview (free)

 

6 – TV viewing and incident venous thromboembolism: the Atherosclerotic Risk in Communities Study – Journal of Thrombosis and Thrombolysis (free)

Commentaries: Turn it off: Binge watching TV can cause venous thromboembolism—even if you’re fit – Cardiovascular Business (free) AND How too much TV could kill you – MedicalNewsToday (free)

Related article: Watching Television and Risk of Mortality From Pulmonary Embolism Among Japanese Men and Women – Circulation (free)

 

7 – Cancer diagnosis in patients with heart failure: epidemiology, clinical implications and gaps in knowledge – European Journal of Heart Failure (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)

 

8 – Robot-assisted laparoscopic surgery versus conventional laparoscopic surgery in randomized controlled trials: A systematic review and meta-analysis – PLOS One (free)

“Despite higher operative cost, robot-assisted laparoscopic surgery does not result in statistically better treatment outcomes, with the exception of lower estimated blood loss. Operative time and total complication rate are significantly more favorable with conventional laparoscopic surgery”.

 

9 – Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease: Systematic Review and Network Meta-analysis – Journal of the American Geriatrics Society (free)

Source: Medscape (free registration required)

“Cognitive enhancers in general have minimal effects on cognition according to minimal clinically important difference and global ratings. The drugs appear safe, but this must be interpreted cautiously because trial participants may have less comorbidity and fewer adverse effects than those treated with these drugs in clinical practice”.

 

10 – A Time-Motion Study of Primary Care Physicians’ Work in the Electronic Health Record Era – Family Medicine (free)

Commentary: EHR Time Exceeds Patient Face Time in Family Practice Visits – Medscape (free registration required)

Related: Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout – National Academy of Medicine (free) AND Date Night with the EHR – NEJM Catalyst (free) AND Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians(free)

 


 

1 – Efficacy of self-monitored blood pressure, with or without telemonitoring, for titration of antihypertensive medication (TASMINH4): an unmasked randomised controlled trial – The Lancet (free)

Commentaries: Hypertension: time for doctors to switch the driver’s seat? (free) AND Should home-based blood pressure monitoring be commonplace in NHS? – University of Oxford News & Events (free)

“Self-monitoring, with or without telemonitoring, when used by general practitioners to titrate antihypertensive medication in individuals with poorly controlled blood pressure, leads to significantly lower blood pressure than titration guided by clinic readings”.

 

2 – Clinical course of untreated cervical intraepithelial neoplasia grade 2 under active surveillance: systematic review and meta-analysis – The BMJ (free)

Editorial: Treatment or surveillance for CIN2? (free)

Commentaries: Treatment or surveillance for CIN2: when less is more – The BMJ Opinion (free) AND Some irregular cervical lesions could be monitored rather that treated immediately – OnMedica (free) AND Regular monitoring rather than immediate treatment justified for some cervical lesions – EurekAlert (free)

 

3 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Hemorrhoids – Diseases of the Colon & Rectum (free)

Related guideline: ACG Clinical Guideline: Management of Benign Anorectal Disorders – The American Journal of Gastroenterology (free)

 

4 – Association of Varicose Veins With Incident Venous Thromboembolism and Peripheral Artery Disease – JAMA (link to abstract – $ for full-text)

Commentaries: Patients with varicose veins at greater risk for thrombosis, other vascular diseases – Cardiovascular Business (free) AND Varicose Veins Linked to Greater Risk for VTE, PAD – NEJM Physician’s First Watch (free) AND Varicose Veins May Increase Likelihood of Blood Clots – Physician’s Weekly (free)

 

5 – Sex Differences in the Association Between Measures of General and Central Adiposity and the Risk of Myocardial Infarction: Results From the UK Biobank – Journal of the American Heart Association (free for a limited period)

Commentaries: Wait and hip measurement better indicator of heart attack risk than obesity – OnMedica (free) AND Larger waist, hips may raise women’s heart attack risk – MedicalNewsToday (free)

 

6 – Impact of frailty on outcomes after discharge in older surgical patients: a prospective cohort study – Canadian Medical Association Journal (free)

Commentary: Frailty associated with readmission risk and postdischarge mortality in older surgical patients – ACP Hospitalist (free)

Related Systematic Review: Identifying older adults at risk of harm following elective surgery: a systematic review and meta-analysis – BMC Medicine (free) AND Commentary: Age itself is not a risk factor for complications after surgery among older patients – OnMedica (free)

 

7 – Korean Guidelines for the Pharmacological Treatment of Social Anxiety Disorder: Initial Treatment Strategies – Psychiatric Investigation (free)

Related guideline: Social anxiety disorder: recognition, assessment and treatment – NICE (free) AND Summary: Recognition, assessment and treatment of social anxiety disorder: summary of NICE guidance – The BMJ (free)

 

8 – Patterns and Predictors of Short-Term Peripherally Inserted Central Catheter Use: A Multicenter Prospective Cohort Study – Journal of Hospital Medicine (free PDF)

Commentary: Short-term use of IV devices is common — and risky — study shows – University of Michigan, via ScienceDaily (free)

“Intravenous devices known as PICCs should be reserved for long-term use, but a new study shows 1 in 4 are used for 5 days or less” (from ScienceDaily)

 

9 – Real-World Effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients With Bipolar Disorder – JAMA Psychiatry (link to abstract – $ for full-text)

Editorial: Enthusiasm and Skepticism About Using National Registers to Analyze Psychotropic Drug Outcomes (free for a limited period)

Commentaries: Lithium treatment for bipolar disorder linked to lowest risk of rehospitalization – Karolinska Institutet, via EurekAlert (free) AND Lithium Top Choice for Preventing Bipolar Rehospitalization – MedPage Today (free registration required)

Related study: Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: a systematic review of evidence from observational studies – Bipolar Disorders (free)

These observational studies suggest Lithium may be a better choice for treating these patients, but long-term randomized controlled trials are needed to clarify this issue (see editorial).

 

10 – Beta-blocker Therapy and Clinical Outcomes in Patients with Moderate COPD and Heightened Cardiovascular Risk: An Observational Sub-study of SUMMIT – Annals of the American Thoracic Society (link to abstract – $ for full-text)

Commentary: Beta-blockers may not change COPD lung function – Univadis (free registration required)

Related review and meta-analysis: Beta-blockers in patients with chronic obstructive disease and coexistent cardiac illnesses – COPD Research and Practice (free) AND Beta-blocker use and COPD mortality: a systematic review and meta-analysis – BMC Pulmonary Medicine (free)

Related observational studies: β-Blockers in COPD: A Cohort Study From the TONADO Research Program – CHEST (free) AND Effect of β blockers in treatment of chronic obstructive pulmonary disease: a retrospective cohort study – The BMJ (free)

 


 

1 – Balanced Crystalloids versus Saline in Critically Ill Adults – New England Journal of Medicine (free)

Related article: Balanced Crystalloids versus Saline in Noncritically Ill Adults – New England Journal of Medicine (free)

Commentary: Balanced Crystalloids May Be Better Than Saline for Critically Ill Patients – NEJM Physician’s First Watch (free)

Balanced crystalloids may be superior to saline in critically ill patients — but not in patients hospitalized outside an ICU” (from Physician’s First Watch)

 

2 – Impact of Bystander Automated External Defibrillator Use on Survival and Functional Outcomes in Shockable Observed Public Cardiac Arrests – Circulation (free PDF for a limited period)

Commentary: Bystander defibrillator use tied to better cardiac arrest outcomes – Reuters (free)

Related articles: The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text) AND Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (Link to abstract – $ for full-text)

 

3 – Medical Education: Hidden Curricula, Ethics, and Professionalism: Optimizing Clinical Learning Environments in Becoming and Being a Physician: A Position Paper of the American College of Physicians – Annals of Internal Medicine (free)

News Release: ACP calls on medicine to optimize learning environments by aligning positive ’hidden’ curriculum with formal curriculum of medical education (free)

 

4 – 2018 consensus of the Taiwan Society of Cardiology and the Diabetes Association of Republic of China (Taiwan) on the pharmacological management of patients with type 2 diabetes and cardiovascular diseases – Journal of the Chinese Medical Association (free)

Related guideline: Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes, 2018 – American Diabetes Association (free)

 

5 – Management of anaemia and iron deficiency in patients with cancer: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

6 – Nutritional labelling for healthier food or non-alcoholic drink purchasing and consumption – Cochrane Library (free)

News release: New Cochrane Review evidence suggests that nutritional labelling on menus in restaurants and cafes may reduce our calorie intake (free)

Video: Nutritional labelling for healthier food or non alcoholic purchasing and consumption (free)

Commentary: Expert reaction to Cochrane review on nutrition labelling and calorie intake – Science Media Centre (free)

For a typical lunch with an intake of 600 calories, such as a slice of pizza and a soft drink, labelling may reduce the energy content of food purchased by about 8% (48 calories)”

 

7 – Association Between Bariatric Surgery and Rates of Continuation, Discontinuation, or Initiation of Antidiabetes Treatment 6 Years Later – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Bariatric Surgery Associated With Reduced Need For Diabetes Medications at Six Years – MedicalResearch (free) AND Roughly Half of Obese Patients Who Have Bariatric Surgery Are Off Type 2 Diabetes Meds at 6 Years – TCTMD (free)

See related studies on the long-term effects of Bariatric Surgery in our January 17th issue (see #1, #2 and #3)

 

8 – Pediatric Palliative Care for Children with Progressive Non-Malignant Diseases – Children (free)

 

9 – Plastic Additive BPA Not Much Of A Threat, Government Study Finds – NPR (free)

See original FDA statement on National Toxicology Program draft report on Bisphenol A (free) AND Endocrine Society Experts Express Concern with FDA Statement on BPA Safety – Endocrine Society, via NewsWise (free)

 

10 – Cardiac Arrest in the Operating Room: Resuscitation and Management for the Anesthesiologist Part 1 – Anesthesia & Analgesia (free)

See also: Cardiac Arrest in the Operating Room: Part 2—Special Situations in the Perioperative Period (free)

Source: Critical Care Reviews Newsletter

 


 

1 – 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free)

Related guidelines: 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease (free)

 

2 – Guidelines for Adolescent Depression in Primary Care – American Academy of Pediatrics

Part I. Practice Preparation, Identification, Assessment, and Initial Management (free)

 Part II. Treatment and Ongoing Management (free)

Commentary: Pediatricians Call For Universal Depression Screening For Teens – NPR (free)

 

3 – Guidelines for Burn Care Under Austere Conditions: Surgical and Nonsurgical Wound Management – Journal of Burn Care & Research (free)

See also: Guideline for Burn Care Under Austere Conditions: Special Care Topics (free)

Source: Critical Care Reviews Newsletter

 

4 – “Is there a doctor on board?”: Practical recommendations for managing in-flight medical emergencies – Canadian Medical Association Journal (free)

News release: Responding to inflight medical emergencies can be stressful for doctors – CMAJ News (free)

Related video: Managing medical emergencies at 36,000 ft: A guide to Air Canada’s in-flight emergency medical kit (free)

 

5 – Impact of treatment delay on mortality in ST-segment elevation myocardial infarction (STEMI) patients presenting with and without haemodynamic instability: results from the German prospective, multicentre FITT-STEMI trial – European Heart Journal (free)

Commentaries: 3% rise in deaths for every 10 min delay in restoring blood flow after heart attack – OnMedica (free) AND Treatment Delay and Mortality in STEMI With Shock – American College of Cardiology, Latest in Cardiology (free)

 

6 – Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (free)

Original article: Interventions for paracetamol (acetaminophen) overdose – Cochrane Library (link to abstract – $ for full-text)

 

7 – Richard Lehman’s journal review, 26 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – FDA Safety Alert: Clarithromycin (Biaxin): Drug Safety Communication – Potential Increased Risk of Heart Problems or Death in Patients With Heart Disease (free)

Commentaries: FDA: Antibiotic Linked to Increased Risk of Death in Heart Disease Patients – MPR (free) AND FDA: Clarithromycin Risks Persist in Patients With CAD – TCTMD (free) FDA Alert: Clarithromycin Risky in Patients With Heart Disease – Medscape (free registration required)

 

9 – Idiopathic pulmonary fibrosis: pathogenesis and management – Respiratory Research (free)

Related guidelines: An Official ATS/ERS/JRS/ALAT Clinical Practice Guideline: Treatment of Idiopathic Pulmonary Fibrosis (free) AND German Guideline for Idiopathic Pulmonary Fibrosis – Update on Pharmacological Therapies 2017 – Pneumologie (free) AND Diagnosis and management of idiopathic pulmonary fibrosis: French practical guidelines – European Respiratory Review (free) AND Idiopathic pulmonary fibrosis in adults: diagnosis and management – NICE (free)

 

10 – Effect of the Pulmonary Embolism Rule-Out Criteria on Subsequent Thromboembolic Events Among Low-Risk Emergency Department Patients: The PROPER Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Pulmonary Embolism Rule-out Criteria non-inferior to usual care for patients at low-risk for pulmonary embolism – 2 Minute Medicine (free) AND EM Nerd-The Case of the Diagnostic Absurdity (free) AND Using PERC & Sending Home Pulmonary Emboli For Fun and Profit – Emergency Literature of Note (free)

 


 

1 – Latent TB Infection: Updated and consolidated guidelines for programmatic management – World Health Organization (free)

News release: WHO issues new recommendations calling for accelerated uptake of testing and treatment for TB prevention (free)

 

2 – ACG Clinical Guideline: Alcoholic Liver Disease – The American Journal of Gastroenterology (free)

Commentary and summary: New Guideline for Management of Alcoholic Liver Disease – NEJM Journal Watch (free for a limited period)

 

3 – Prediction of cardiovascular risk factors from retinal fundus photographs via deep learning – Nature Biomedical Engineering (link to abstract – $ for full-text) (via @EricTopol see Very interesting Tweet)

Commentaries: Assessing Cardiovascular Risk Factors with Computer Vision – Google Research Blog (free) AND Google’s new AI algorithm predicts heart disease by looking at your eyes – TheVerge (free) AND Combination of AI, eye images could predict cardiovascular disease – Cardiovascular Business (free) AND It’s All in the Eyes: Google AI Calculates Cardiovascular Risk From Retinal Images – Medium (free)

 

4 – Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Related guidelines: Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) (free) AND Management of febrile neutropaenia: ESMO Clinical Practice Guidelines (free) AND Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)

 

5 – Opinion: Doctors, Revolt! – The New York Times (free)

“Healing is replaced with treating, caring is supplanted by managing, and the art of listening is taken over by technological procedures. Bernard Lown” (via @lucadf see Tweet)

 

6 – The global crackdown on parents who refuse vaccines for their kids has begun – VOX (free)

“Countries like Italy and Australia are tired of measles outbreaks — so they’re moving to fine anti-vaccine parents”.

 

7 – Scientists Aim to Pull Peer Review Out Of The 17th Century – NPR (free)

Related: The Future of Peer Review – Scientific American (free) AND Peer review is a black box. Let’s open it up – STAT News (free) AND Exposing peer review – Research Information (free) AND Researchers debate whether journals should publish signed peer reviews – Science (free) AND The peer-review system for academic papers is badly in need of repair – The Conversation (free)

 

8 – Antifibrinolytic drugs for treating primary postpartum haemorrhage – Cochrane Library (free)

Related: Updated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free PDF) AND Early use of tranexamic acid reduces bleeding more effectively – NIHR Signal (free) AND Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free)

 

9 – Spironolactone Versus Clonidine as a Fourth-Drug Therapy for Resistant Hypertension: The ReHOT Randomized Study (Resistant Hypertension Optimal Treatment) – Hypertension (free)

Commentary: Spironolactone bests clonidine as fourth drug for resistant hypertension – Univadis (free registration required)

 

10 – Infant Hospitalizations and Mortality After Maternal Vaccination – Pediatrics (free)

Commentaries: Maternal vaccination during pregnancy not associated with infant hospitalization, mortality – 2 Minute Medicine (free) AND Getting Recommended Vaccines During Pregnancy Doesn’t Lead to Harm in Infants – Physician’s First Watch (free)

 


 

1 – Spontaneous Coronary Artery Dissection: Current State of the Science: A Scientific Statement From the American Heart Association – Circulation (free PDF)

See also: Commentary: Spontaneous Coronary Artery Dissection: Making strides, long journey ahead! (free) AND Top Ten Things to Know (free PDF)

 

2 – Diagnosis and Treatment of Neurocysticercosis: 2017 Clinical Practice Guidelines by the Infectious Diseases Society of America (IDSA) and the American Society of Tropical Medicine and Hygiene (ASTMH) – Clinical Infectious Diseases (free)

 

3 – Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis – The Lancet (free)

Commentaries: More data, more answers: picking the optimal antidepressant – The Lancet (free) AND All antidepressants are more efficacious than placebo – OnMedica (free) AND Expert reaction to largest review of antidepressants – Science Media Centre (free) AND Antidepressants can help adults with major depression – The Mental Elf (free)

 

4 – Human Neonatal Rotavirus Vaccine (RV3-BB) to Target Rotavirus from Birth – New England Journal of Medicine (free)

Commentaries: New rotavirus vaccine to curb child deaths in developing countries – New Zealand Doctor (free) AND Researchers successfully develop a rotavirus vaccine which could benefit millions of children – MedicalXpress (free)

 

5 – Potential workload in applying clinical practice guidelines for patients with chronic conditions and multimorbidity: a systematic analysis – BMJ Open (free) (via @acpatient and @MaryDixonWoods)

 

6 – The Origin of Spousal Resemblance for Alcohol Use Disorder – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: For Better or Worse: Risk of Alcohol Use Disorder Rises When Spouse is Diagnosed – Psychiatric News Alert (free) AND Spouses have strong influence on risk for alcohol abuse – Reuters (free)

 

7 – Cleaning at Home and at Work in Relation to Lung Function Decline and Airway Obstruction – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentaries: Women Who Clean at Home or Work Face Increased Lung Function Decline – American Thoracic Society, via NewsWise (free) AND Cleaning Chemicals ‘Likely Cause Substantial Damage To Women’s Lungs’, Study Finds – Huffpost (free) AND Cleaning at home or work linked to faster lung function decline in women – Univadis (free registration required)

 

8 – Perspective: Our Other Prescription Drug Problem – New England Journal of Medicine (free)

Related opinion: Benzodiazepines: our other prescription drug epidemic – STAT (free)

 

9 – Perspective: The Psychology of Clinical Decision Making — Implications for Medication Use – New England Journal of Medicine (free)

 

10 – Robot-assisted radical prostatectomy vs laparoscopic and open retropubic radical prostatectomy: functional outcomes 18 months after diagnosis from a national cohort study in England – British Journal of Cancer (free)

Commentary: After-effects not necessarily reduced with robotic prostate surgery – Reuters (free)

Related Cochrane Review with similar results: Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (free)

 


 

1 – Aspirin or Rivaroxaban for VTE Prophylaxis after Hip or Knee Arthroplasty – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Preventing VTE after Hip or Knee Arthroplasty (free)

Among patients who received 5 days of rivaroxaban prophylaxis after total hip or total knee arthroplasty, extended prophylaxis with aspirin was not significantly different from rivaroxaban in the prevention of symptomatic venous thromboembolism”.

 

2 – Guideline: Peripheral arterial disease: diagnosis and management – National Institute for Health and Care Excellence (NICE) (free)

 

3 – Guideline: Heavy menstrual bleeding: assessment and management – National Institute for Health and Care Excellence (NICE) (free)

 

4 – Sex Differences in Ischemic Heart Disease: Advances, Obstacles, and Next Steps – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)

Related AHA Scientific Statement: Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science (free)

 

5 – Are you ready for the ATLS 10th Edition Updates? – emDocs (free)

Related: Infographic: ATLS Trauma Update 2018

 

6 – Ischaemic stroke, haemorrhage, and mortality in older patients with chronic kidney disease newly started on anticoagulation for atrial fibrillation: a population based study from UK primary care – The BMJ (free)

Commentaries: Anticoagulants Tied With Stroke, Hemorrhage in CKD – Renal & Urology News (free) AND Could a Blood Thinner Actually Raise Stroke Risk for Some? – HealthDay (free) AND Anticoagulants for Patients with Afib and Kidney Disease? Study Yields Mixed Findings – Physician’s First Watch (free) AND Blood-thinning drugs designed to cut stroke risk may actually increase it – The Guardian (free)

“Given the lack of guidelines, the decision to start anticoagulant treatment in patients with chronic kidney disease and new onset atrial fibrillation should be made on an individual basis, concludes research” (via @bmj_latest see Tweet)

 

6 – Current concepts of fluid management in enhanced recovery pathways – British Journal of Anaesthesia (free)

See other Enhanced Recovery After Surgery Guidelines and Reviews

 

7 – Association of Cigarette, Cigar, and Pipe Use With Mortality Risk in the US Population – JAMA Internal Medicine (free for a limited period)

Commentaries: Cigars and pipes tied to same risks as cigarettes – Reuters (free) AND Cigars and pipes raise mortality risk independent of cigarettes – OnMedica (free)

 

8 – It’s poverty, not individual choice, that is driving extraordinary obesity level – The Conversation (free)

“Statistics point remorselessly towards obesity being a symptom with an underlying social cause”.

 

9 – Outcomes of non-invasive diagnostic modalities for the detection of coronary artery disease: network meta-analysis of diagnostic randomised controlled trials – The BMJ (free)

Among patients with low risk acute coronary syndrome, stress echocardiography, cardiovascular magnetic resonance, and exercise electrocardiograms resulted in fewer invasive referrals for coronary angiography than coronary computed tomographic angiography, without apparent impact on the future risk of myocardial infarction. Similarly, for outpatients with suspected stable angina, an initial strategy based on functional testing might be preferable, resulting in fewer referrals for invasive coronary angiography and revascularization, without a statistically significant difference in the future risk of MI.

 

10 – Maternal thyroid function and child educational attainment: prospective cohort study – The BMJ (free)

Related study and commentary: Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy – New England Journal of Medicine (free) AND Treating subclinical thyroid dysfunction in pregnancy probably has no benefit – NIHR Signal (free)

Maternal thyroid dysfunction in the first trimester had no impact on child performance at school or educational achievement.

 


 

1 – Clinical Guidelines Synopsis: Management of ARDS in Adults – JAMA (free)

Related Review: Acute Respiratory Distress Syndrome: Advances in Diagnosis and Treatment – JAMA (free)

 

2 – Clinical recommendations for high altitude exposure of individuals with pre-existing cardiovascular conditions – European Heart Journal (free)

Commentaries: European experts release guidelines about high-altitude exposure for cardiovascular patients – Cardiovascular Business (free) AND A trip to the mountains despite a heart condition? – Eurac Research, via ScienceDaily (free)

 

3 – Contribution of alcohol use disorders to the burden of dementia in France 2008–13: a nationwide retrospective cohort study – The Lancet Public Health (free)

Commentaries: Alcohol and dementia: a complex relationship with potential for dementia prevention – The Lancet Public Health (free) AND Expert reaction to study looking at alcohol use disorders and dementia risk – Science Media Centre (free) AND Heavy Drinking Tied to Early-Onset Dementia in French Study – MedPage Today (free registration required)

“Of 57,000 people diagnosed before age 65 with early-onset dementia, 39% had alcohol-related dementia by definition, and 18% had an additional diagnosis of alcohol use disorders” (via @medpagetoday see Tweet)

 

4 – Effect of Low-Fat vs Low-Carbohydrate Diet on 12-Month Weight Loss in Overweight Adults and the Association With Genotype Pattern or Insulin Secretion: The DIETFITS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Low-Carb And Low-Fat Diets Battle To A Draw – Cardiobrief (free) AND Matching DNA to a diet doesn’t work: ‘We didn’t even come close,’ researcher says – STAT (free) AND Counting Calories Is Not the Key to Weight Loss, New Study Finds – The New York Times (10 articles per month are free) AND Debating low-fat vs low-carb diets? New study found a draw – Scope (free)

 

5 – Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium: The REDUCE Randomized Clinical Trial – JAMA (free)

Prophylactic haloperidol in this population with elevated risk of delirium did not reduce mortality or any of the 15 prespecified secondary outcomes, including delirium incidence, 28-day delirium-free and coma-free days, duration of mechanical ventilation, and ICU and hospital length of stay.

 

6 – Review: Adverse pregnancy outcomes and future maternal cardiovascular disease – Clinical Cardiology (free)

 

7 – Update on Diabetic Nephropathy: Core Curriculum 2018 – American Journal of Kidney Diseases (free)

 

8 – Avoid common mistakes when treating hyponatremia – ACP Hospitalist (free)

 

9 – Analysis: How many lives are at stake? Assessing 2030 sustainable development goal trajectories for maternal and child health – The BMJ (free)

Related review: Countdown to 2030: tracking progress towards universal coverage for reproductive, maternal, newborn, and child health – The Lancet (free registration required)

 

10 – Real-time continuous glucose monitoring in adults with type 1 diabetes and impaired hypoglycaemia awareness or severe hypoglycaemia treated with multiple daily insulin injections (HypoDE): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

The mean number of hypoglycemic events per 28 days was reduced from 10.8 to 3.5 among patients in the continuous glucose monitoring group and from 14.4 to 13.7 among control group participants.

 


 

1 – Haemodynamic assessment and support in sepsis and septic shock in resource-limited settings – Transactions of The Royal Society of Tropical Medicine and Hygiene (free)

Source: Critical Care Reviews Newsletter

 

2 – Simplified guideline for prescribing medical cannabinoids in primary care – Canadian Family Physician (free)

Commentary: New guideline warns pain benefits of medical cannabis overstated – University of Alberta Faculty of Medicine & Dentistry, via ScienceDaily (free)

 

3 – Systolic Blood Pressure and Outcomes in Patients With Heart Failure With Preserved Ejection Fraction – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: Aggressive Systolic Blood Pressure Control In Older Patients With HFpEF Should Be Avoided – MedicalResearch.com (free) AND Low blood pressure linked to worse outcomes in HFpEF patients – Cardiovascular Business (free)

“A systolic blood pressure level of less than 120 mm Hg identifies patients with heart failure with preserved ejection fraction at higher risk for short- and long-term mortality and emphasizes the need for future prospective studies to evaluate optimal systolic blood pressure treatment goals in this patient population”.

 

4 – Editorial: Vitamin D Screening and Supplementation in Primary Care: Time to Curb Our Enthusiasm – American Family Physician (free)

Related: Your vitamin D tests and supplements are probably a waste of money – VOX (free) AND Why Are So Many People Popping Vitamin D? – The New York Times (free)

 

5 – Interim Estimates of 2017–18 Seasonal Influenza Vaccine Effectiveness — United States, February 2018 – MMWR, Centers for Disease Control and Prevention (free)

Commentaries: US study finds 36% flu vaccine protection, 25% against H3N2 – CIDRAP (free) AND Three-quarters of people who got flu shot this year weren’t protected against most common strain – STAT (free)

 

6 – Review: Delirium in the Cardiac Intensive Care Unit – Journal of the American Heart Association (free for a limited period)

Source: Critical Care Reviews Newsletter

 

7 – New Choosing Wisely Lists in Pediatrics: Four Things Physicians and Patients Should Question in Pediatric Infectious Diseases and Medical Microbiology – Choosing Wisely Canada (free) AND Five Things Physicians and Patients Should Question in Pediatric Orthopedics – Choosing Wisely U.S. (free)

Related: The Choosing Wisely initiative was launched 5 years ago, and now has over 490 recommendations from 18 countries (free)

See complete lists from Choosing Wisely U.S., Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

8 – Expert opinion: ‘UTI’ an overused diagnosis in the era of the microbiome – ACP Hospitalist (free)

 

9- Technology: Wanted: a WhatsApp alternative for clinicians – The BMJ Opinion (free)

 

10 – Breast Biopsy Intensity and Findings Following Breast Cancer Screening in Women With and Without a Personal History of Breast Cancer – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Breast MRIs may lead to more biopsies that catch fewer cancers – Reuters (free) AND MRI-Based Breast Screening Leads to More Biopsies, Lower Cancer Yields – Physician’s First Watch (free)

 


 

1 – Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder: Synopsis of the Kidney Disease: Improving Global Outcomes 2017 Clinical Practice Guideline Update – Annals of Internal Medicine (free)

 

2 – Hydroxychloroquine Effectiveness in Reducing Symptoms of Hand Osteoarthritis: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Hydroxychloroquine no more effective than placebo for relieving osteoarthritis hand pain – American College of Physicians, via EurekAlert (free)

 

3 – Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation – British Journal of Anaesthesia (free)

 

4 – Short-Term Versus Long-Term Dual Antiplatelet Therapy After Drug-Eluting Stent Implantation in Elderly Patients: A Meta-Analysis of Individual Participant Data From 6 Randomized Trials – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

Commentary: Dual Antiplatelet Therapy Duration in Elderly Patients – American College of Cardiology, Latest in Cardiology (free)

Short-term Dual Antiplatelet Therapy was not associated with increased risk of ischemic events in elderly patients and was associated with a significant reduction in major bleeding.

 

5 – British Thoracic Society Guideline for the investigation and management of malignant pleural mesothelioma – Thorax (free)

Related guideline: Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline – Journal of Clinical Oncology (free)

 

6 – Opinion: Stories about tragic flu deaths wrongly portray Tamiflu as a panacea – HealthNewsReview (free)

Related: Tamiflu and Relenza: getting the full evidence picture – Cochrane Library (free)

“The review confirms small benefits on symptom relief, namely shortening duration of symptoms by half a day on average. However, there is little evidence to support any belief that use of NIs reduces hospital admission or the risk of developing confirmed pneumonia”. (from Cochrane)

 

7 – Risk of Recurrent Disease and Surgery Following an Admission for Acute Diverticulitis – Diseases of the Colon and Rectum (link to abstract – $ for full-text)

Commentary: Which Patients with Diverticulitis Require Surgery? – Diseases of the Colon & Rectum, via NewsWise (free)

In this large cohort of 65,162 patients identified with a first episode of acute diverticulitis, younger patients, women, smokers, obese individuals, and those who had diverticulitis with perforation and/or abscess were more likely to develop recurrent diverticulitis.

 

8 – Richard Lehman’s journal reviews, 19 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Review: Anaphylaxis – Chest (free)

Source: Critical Care Reviews Newsletter

 

10 – Incidence, Etiology, and Outcomes of Community-Acquired Pneumonia: A Population-Based Study – Open Forum Infectious Diseases (free)

“Aside from the rare extra-pulmonary manifestations of mycoplasma (e.g., rashes, hemolysis, neurologic complications), do any of the many causes of pneumonia have distinctive clinical presentations? Probably not”. (via @PaulSaxMD see Tweet)

 


 

1 – WHO recommendations: intrapartum care for a positive childbirth experience – World Health Organization (free)

News release: Individualized, supportive care key to positive childbirth experience, says WHO (free)

Commentary: Give women more time to give birth, make choices – WHO – Reuters (free)

 

2 – Clinical Practice Guidelines for Clostridium difficile Infection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) (free)

Commentary: Fecal transplants move into the mainstream to treat difficult infection – STAT (free)

 

3 – Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: No benefit of sodium bicarbonate or acetylcysteine for prevention of complications after angiography: The PRESERVE trial – 2 Minute Medicine (free) AND Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine – NEJM Resident 360 (free)

“Among patients at high risk for renal complications who were undergoing angiography, there was no benefit of intravenous sodium bicarbonate over intravenous sodium chloride or of oral acetylcysteine over placebo for the prevention of death, need for dialysis, or persistent decline in kidney function at 90 days or for the prevention of contrast-associated acute kidney injury”.

 

4 – Review: Physical Activity in the Prevention and Treatment of Coronary Artery Disease – Journal of the American Heart Association (free for a limited period)

 

5 – Consumption of ultra-processed foods and cancer risk: results from NutriNet-Santé prospective cohort – The BMJ (free)

Editorial: Ultra-processed foods and cancer (free)

Commentaries: ‘Ultra-processed’ foods and cancer: Headlines show the right way, and the wrong way, to frame results from an observational study – HealthNewsReview (free) AND Expert reaction to study looking at highly processed foods and cancer – Science Media Centre (free)

 

6 – Edoxaban for the Treatment of Cancer-Associated Venous Thromboembolism – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Edoxaban for Cancer-Associated Venous Thromboembolism (free)

Commentaries: Edoxaban Noninferior to Dalteparin for Cancer-Associated VTE – Physician’s First Watch (free) AND Oral Edoxaban Noninferior to Dalteparin for Cancer-Related Venous Thromboembolism – Cardiology Advisor (free)

 

7 – Mortality in single fathers compared with single mothers and partnered parents: a population-based cohort study – The Lancet Public Health (free)

Commentaries: Premature mortality in single fathers – The Lancet Public Health (free) AND Single fathers have highest risk of early death – OnMedica (free) AND Single Fathers Are More Likely to Die Early, Study Says – TIME (free)

 

8 – Risk of Dementia in Adults With Congenital Heart Disease: Population-Based Cohort Study – Circulation (free PDF)

Commentaries: Congenital heart defects linked to increased risk of dementia – American Heart Association News (free) AND Adult Survivors of Congenital Heart Disease at Increased Risk of Dementia – TCTMD (free)

 

9 – Polygenic Contribution in Individuals With Early-Onset Coronary Artery Disease – Circulation: Genomic and Precision Medicine (free)

Commentary: Genetic Risk Score May Best FH Variant for Predicting Early-Onset CAD – Medscape (free registration required)

“Another study suggests CAD will soon be predicted not by 1 gene (like FH) but groups of genes that can be combined into risk scores” (via @drjohnm see Tweet)

 

10 – Direct Oral Anticoagulants in Addition to Antiplatelet Therapy for Secondary Prevention After Acute Coronary Syndromes: A Systematic Review and Meta-analysis – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: Could NOACs Have a Role for Secondary Prevention After STEMI? – TCTMD (free) AND Meta-Analysis: ACS Type Matters for DOAC Use in Secondary Prevention – MedPage Today (free registration required) AND Adding DOACs Beneficial for STEMI — Not Non-STEMI — But with Bleeding Risk – Physician’s First Watch (free)

63 STEMI patients would need to receive a DOAC to prevent one cardiovascular event, while 96 would need to be treated to cause one major bleeding event”. (from Physician’s First Watch)

 


 

1 – Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Preliminary Report – The New England Journal of Medicine (free)

A fractional dose containing one fifth of the standard dose was effective at inducing seroconversion, supporting the use of fractional-dose vaccination for outbreak control.

 

2 – Evidence-based clinical practice guidelines for inflammatory bowel disease – Journal of Gastroenterology (free)

 

3 – Medical News & Perspectives: Do All Patients Need β-Blockers After a Heart Attack? – JAMA (free for a limited period)

 

4 – The state of OA: a large-scale analysis of the prevalence and impact of Open Access articles – PeerJ (free)

 

5 – Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free)

Commentary: New Guidelines for Treating Checkpoint Inhibitor Toxicities – Medscape (free registration required)

Relate guideline: Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free) AND Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 

6 – Uterine Neoplasms, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology (free)

 

7 – New Dutch law to make all adults organ donors unless they opt out – CNN (free) AND Every Adult in This Country Is Now an Organ Donor Unless They Opt Out – TIME (free) AND Dutch law to make everyone organ donors unless they opt out – ABC News (free)

 

8 – Benefits and Harms of Cranial Electrical Stimulation for Chronic Painful Conditions, Depression, Anxiety, and Insomnia: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Mild shock therapy may ease anxiety and depression, but not chronic pain – Reuters (free) AND Jury Still Out on CES for Depression, Anxiety, Pain, Insomnia – Medscape (free registration required)

 

9 – Opioid Analgesic Use and Risk for Invasive Pneumococcal Diseases: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Opioids may be associated with increased risk for serious invasive pneumococcal infections – ACP Internist (free) AND Opioids For Pain Can Exacerbate Pneumococcal Infections – MedicalResearch.com (free) AND Prescription Opioid Use Tied to Higher Pneumonia Risk – MedPage Today (free registration required)

 

10 – Surgical site infection after gastrointestinal surgery in high-income, middle-income, and low-income countries: a prospective, international, multicentre cohort study – The Lancet Infectious Diseases (free)

Commentaries: Surgical site infection—the next frontier in global surgery – The Lancet Infectious Diseases (free) AND Poor nations have higher risk of surgical infections, including resistant ones – CIDRAP (free)

 


 

1 – Family Planning – A global handbook for providers: 2018 edition – World Health Organization (free)

News release: Updated and expanded guidance for family planning providers worldwide (free)

 

2 – Guideline: Antiarrhythmic drugs–clinical use and clinical decision making: a consensus document from EHRA, ESC, HRS, APHRS and ISCP (free)

Source: Antiarrhythmics: multinational consensus recommendations – Univadis (free registration required)

 

3 – Screening for Ovarian Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Ovarian Cancer in Asymptomatic Women (free) AND The Yet Unrealized Promise of Ovarian Cancer Screening (free) AND Is There a Future for Ovarian Cancer Screening? (free)

Author interview: USPSTF Recommendation: Screening for Ovarian Cancer (free audio)

“The USPSTF recommends against screening for ovarian cancer in asymptomatic women. (D recommendation) This recommendation applies to asymptomatic women who are not known to have a high-risk hereditary cancer syndrome”.

 

4 – Association of Combined Patterns of Tobacco and Cannabis Use in Adolescence With Psychotic Experiences – JAMA Psychiatry (free)

Commentaries: Risk of Psychotic Experiences Up With Teen Cannabis Use – Physician’s Briefing (free) AND Teen Pot Use Linked to Increased Risk for Psychotic Episodes – MedPage Today (free registration required)

 

5 – Randomized Trial of Dexamethasone Versus Prednisone for Children with Acute Asthma Exacerbations – The Journal of Pediatrics (link to abstract – $ for full-text)

Commentary: Asthma Exacerbation in Kids: A Trial of Two Steroids – Medscape (free registration required)

Related meta-analysis: Dexamethasone for Acute Asthma Exacerbations in Children: A Meta-analysis – Pediatrics (free PDF)

Related study in adults: A Randomized Controlled Noninferiority Trial of Single Dose of Oral Dexamethasone Versus 5 Days of Oral Prednisone in Acute Adult Asthma – Annals of Emergency Medicine (link to abstract – $ for full-text) AND Commentary: Single Dose Dexamethasone or 5 Days of Prednisone in Adult Asthmatics? – R.E.B.E.L.EM commentary (free full-text)

 

6 – Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer – New England Journal of Medicine (free)

Apalutamide improves castration resistant prostate CA survival compared with… placebo. Why wasn’t it compared w bicalutamide?” (via @RichardLehman1 see Tweet). See Richard Lehman’s point of view

 

7 – In Sweeping War on Obesity, Chile Slays Tony the Tiger – The New York Times (10 articles per month are free)

 

8 – One Health Approach is Critical to De-risk Human, Animal and Environmental Health – The World Bank (free)

See report: Operational Framework for Strengthening Human, Animal And Environmental Public Health Systems At Their Interface – The World Bank (free PDF)

Related review: The science behind One Health: at the interface of humans, animals, and the environment – Annals of the New York Academy of Sciences (free)

 

9 – Comprehensive geriatric assessment for older people admitted to a surgical service – Cochrane Library (free)

Summary: Does special assessment of older people getting surgery improve their recovery after surgery? – Cochrane Library (free)

 

10 – Cancer risk associated with chronic diseases and disease markers: prospective cohort study – The BMJ (free)

Commentaries: Study reveals substantial impact of chronic diseases on cancer risk – eCancer News (free) AND Chronic Disease Linked To Increased Risk of Cancer and Cancer Death – MedicalResearch.com (free) AND Double Trouble: These Diseases Could Raise Your Risk for Cancer – Live Science (free) AND Higher cancer risk from chronic diseases – OnMedica (free)

 


 

1 – Delayed umbilical cord clamping reduces hospital mortality for preterm infants – NIHR Signal (free)

Original article: Delayed vs early umbilical cord clamping for preterm infants: a systematic review and meta-analysis – American Journal of Obstetrics & Gynecology (free)

 

2 – Effect of early and systematic integration of palliative care in patients with advanced cancer: a randomised controlled trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Early Integration of Palliative Care Improves Quality of Life in Advanced Cancer – Oncology Nurse Advisor (free)

Related Guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free) AND Commentary: Concurrent Palliative Care: Recommendations From the ASCO Clinical Practice Guideline – The ASCO Post (free)

 

3 – Infographic: ATLS Trauma Update 2018 (free) (via @CritCareReviews)

 

4 – The Hypertension Guideline War Is Not A Fake War – Cardiobrief (free)

Related: The Fake Hypertension War: Medical politics and mud fights – MedPage Today (free registration required)

 

5 – Overtesting and undertesting in primary care: a systematic review and meta-analysis – BMJ Open (free) (via @JackOSullivan3 and @KariTikkinen)

 

6 – Opinion: Heart Stents Are Useless for Most Stable Patients. They’re Still Widely Used – The New York Times (10 articles per month are free)

 

7 – State of The Art Review: The role of robotics in colorectal surgery – The BMJ (free for a limited period)

 

8 – Richard Lehman’s journal reviews, 12 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Trimethoprim use for urinary tract infection and risk of adverse outcomes in older patients: cohort study – The BMJ (free)

“Trimethoprim is associated with a greater risk of acute kidney injury and hyperkalaemia compared with other antibiotics used to treat UTIs, but not a greater risk of death”

 

10 – FIGO consensus guidelines on placenta accreta spectrum disorders – International Journal of Gynecology & Obstetrics

– Introduction (free)

– Epidemiology (free)

– Prenatal Diagnosis and Screening (free)

– Nonconservative surgical management (free)

 


 

1 – 10 threats to global health in 2018 – The World Health Organization (free)

 

2 – Environmental Noise and the Cardiovascular System – Journal of the American College of Cardiology (free for a limited period)

Commentaries: Everyday noises may cause increased risk of heart disease, experts say – ABC News (free) AND How Loud Noise Exposure Is Linked to Heart Disease – TIME (free) AND Traffic Noise Linked to Increased CVD Risk – Medscape (free registration required) AND Heart & hearing: Noise pollution tied to higher risk of stroke, MI – Cardiovascular Business (free)

 

3 – Energy Drinks: A Contemporary Issues Paper – American College of Sports Medicine (free)

Commentary: ACSM Announces New Recommendations and Warnings Regarding Safety of Energy Drinks – NewsWise (free)

Related: Energy and sports drinks in children and adolescents – Canadian Paediatric Society (free) AND Health Effects and Public Health Concerns of Energy Drink Consumption in the United States: A Mini-Review – Frontiers in Public Health (free)

 

4 – New Cochrane Systematic Reviews – Vaccines for Preventing Influenza and Its Complications

– In Healthy Children (free) / Summary (free)

– In The Elderly (free) / Summary (free)

– In Immunosuppressed Adults With Cancer (free) / Summary (free)

– In Healthy Adults (free) / Summary (free)

 

5 – Report: Weekly U.S. Influenza Surveillance – Centers for Disease Control and Prevention (free)

Commentaries: Flu-like illness in US reaches 2009 pandemic levels – CIDRAP (free) AND Flu Is Causing 1 in 10 American Deaths and Climbing – Bloomberg (free) AND This Flu Season Is the Worst in Nearly a Decade – The New York Times (10 articles per month are free)

 

6 – The Equity Impact Vaccines May Have On Averting Deaths And Medical Impoverishment In Developing Countries – Health Affairs (free)

Commentaries: Study: vaccines prevent not just disease, but also poverty – The Vaccine Alliance (free) AND For world’s poorest, vaccines prevent deaths, medical impoverishment – Harvard T.H. Chan School of Public Health (free)

 

7 – Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

Commentary: New Guidelines Outline Management of Immunotherapy Side Effects – MedPage Today (free registration required) AND SITC Spearheads Initiative for Management of Immunotherapy-Related Side Effects – The ASCO Post (free)

Related review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 

8 – The open abdomen in trauma and non-trauma patients: WSES guidelines – World Journal of Emergency Surgery (free)

 

9 – Review compares effectiveness, cost, and safety of second-line drugs for diabetes – ACP Diabetes Monthly (free)

Original Report: New Drugs for Type 2 Diabetes: Second-Line Therapy – Canadian Agency for Drugs and Technologies in Health (free)

 

10 – Draft Recommendation Statement: Screening Syphilis Infection in Pregnant Women – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Recommends Screening Pregnant Women for Syphilis – American Academy of Family Physicians (free) AND USPSTF: Screening for Syphilis in Pregnant Women Beneficial – MPR (free) AND Syphilis Rising In Newborns, Pregnant Moms: USPSTF Reaffirms Mandatory Testing – American Council on Science and Health (free)

 


 

1 – 2018 annual review of the Blueprint list of priority diseases – World Health Organization (free) (via @equitylist)

Key actions: Diseases for which R&D preparedness activities are already in development – World Health Organization (free)

 

2 – Free online course. Starts 12 February 2018. The Lancet Maternal Health Series: Global Research and Evidence – London School of Hygiene & Tropical Medicine, via Future Learn

“Hear the latest expert evidence from The Lancet Maternal Health Series and learn what you can do to improve maternal healthcare”.

 

3 – Effectiveness of a childhood obesity prevention programme delivered through schools, targeting 6 and 7 year olds: cluster randomised controlled trial (WAVES study) – The BMJ (free)

Editorial: The failure of anti-obesity programmes in schools (free)

Commentary: Obesity crisis can’t be solved by schools – major new study – The Conversation (free) AND Schools are not the answer to childhood obesity epidemic, study shows – The Guardian (free)

“In the words of Winston Churchill, “However beautiful the strategy, you should occasionally look at the results.”” (from editorial)

 

4 – Review: The Management of Multi-vessel disease (MVD) in STEMI: The Science and Art of Decision-Making in STEMI – American College of Cardiology, Latest in Cardiology (free)

 

5 – Update: Stroke in Women: Recognizing Opportunities for Prevention and Treatment – Stroke (free PDF for a limited period)

 

6 – Update: Impact of Conventional Stroke Risk Factors on Stroke in Women – Stroke (free PDF for a limited period)

 

7 – Update: Stroke Risk Factors Unique to Women – Stroke (free PDF for a limited period)

 

8 – Five and 10 minute Apgar scores and risks of cerebral palsy and epilepsy: population based cohort study in Sweden – The BMJ (free)

Infographic: The vital ­first 10 minutes (free PDF)

Even slight changes within the normal Apgar score range (7-10) from five to 10 minutes have a major influence in the risks of cerebral palsy and epilepsy.

 

9 – Management of patients on antithrombotic agents undergoing emergency and elective endoscopy: joint Asian Pacific Association of Gastroenterology (APAGE) and Asian Pacific Society for Digestive Endoscopy (APSDE) practice guidelines – Gut (free)

 

10 – Effectiveness of Family Integrated Care in neonatal intensive care units on infant and parent outcomes: a multicentre, multinational, cluster-randomised controlled trial – The Lancet child & Adolescent Health (link to abstract – $ for full-text)

Commentaries: Premature babies healthier when parents help with hospital care, study shows – The Guardian (free) AND Preemies Fared Better When Parents Helped with NICU Care – MedPage Today (free registration required) AND Parents’ care can help premature babies in hospital, says study – BBC News (free)

 


 

1 – Guideline: Pancreatic cancer in adults: diagnosis and management – National Institute for Health and Care Excellence (free)

News release: Pancreatic cancer patients should be offered early scans to avoid unnecessary surgery, says NICE (free)

 

2 – Intraoperative interventions for preventing surgical site infection: an overview of Cochrane Reviews – Cochrane Library (free)

Summary: Overview of Cochrane Reviews of interventions used during surgery for preventing surgical site infection (free)

 

3 – Prognostic Accuracy of the Quick Sequential Organ Failure Assessment for Mortality in Patients With Suspected Infection: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: For mortality prediction, qSOFA has poor sensitivity, moderate specificity, review finds – ACP Hospitalist (free) AND Systemic inflammatory response syndrome criteria may be more sensitive than quick sequential organ failure assessment for predicting mortality in patients with suspected infection – 2 Minute Medicine (free)

 

4 – Opinion: This flu season, physicians need to scrap the ‘martyr culture’ of working while sick – STAT (free) (via @CMichaelGibson)

Related study: Working with influenza-like illness: Presenteeism among US health care personnel during the 2014-2015 influenza season – American Journal of Infection Control (link to abstract – $ for full-text) AND Commentaries: Working while sick – ACP Internist (free) AND Health worker survey reveals many work during flu illness – CIDRAP (free)

 

5 – New cellphone and health studies don’t eliminate uncertainty – Science (free)

Other commentaries: Largest Animal Study of Cell Phone Radiation and Cancer Risk – Medscape (free registration required) AND High doses of cellphone radiation linked to some cancers in rats – STAT (free) AND Cell phone radiation: Could high exposure cause tumors? – Medical News Today (free)

 

6 – Care-Centered Clinical Documentation in the Digital Environment: Solutions to Alleviate Burnout – National Academy of Medicine (free)

Related Infographic: Date Night with the EHR – NEJM Catalyst (free)

Related Commentary: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free)

Related Guideline: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians(free)

 

7 – ISPOR 2018 – Top 10 Health Economics and Outcomes Research Trends (free PDF)

Commentary: Top 10 Trends Driving Healthcare in 2018 – NewsWise (free)

 

8 – Report: Global Monitoring of Disease Outbreak Preparedness: Preventing the Next Pandemics – Harvard Global Health Institute (free PDF)

See also: News Release (free) AND Summary report (free PDF)

 

9 – Preoperative exercise halves the postoperative complication rate in patients with lung cancer: a systematic review of the effect of exercise on complications, length of stay and quality of life in patients with cancer – British Journal of Sports Medicine (link to abstract – $ for full-text)

Commentaries: Regular exercise halves complication rate after lung cancer surgery – eCancer News (free) AND Lung Cancer Postoperative Complications Reduced With Preoperative Exercise – Pulmonology Advisor (free)

 

10 – Association of Preoperatively Diagnosed Patent Foramen Ovale With Perioperative Ischemic Stroke – JAMA (free for a period)

Commentaries: PFO Diagnosis Linked With Increased Risk of Perioperative Ischemic Stroke After Noncardiac Surgery – TCTMD (free) AND Preoperatively Diagnosed PFO and Perioperative Stroke – American College of Cardiology, Latest in Cardiology (free)

 


 

1 – Policy Statement: Recommended Childhood and Adolescent Immunization Schedules: United States, 2018 – American Academy of Pediatrics (free)

The Immunization Schedules for 2018 are available in the Red Book Online (free) and in the Centers for Disease Control and Prevention Website (free)

 

2 – Rapid Recommendations: Antibiotics after incision and drainage for uncomplicated skin abscesses: a clinical practice guideline – The BMJ (free text and infographics)

 

3 – Report: E-cigarettes and heated tobacco products: evidence review – Public Health England (free PDF)

News release: PHE publishes independent expert e-cigarettes evidence review (free)

Commentaries: UK experts urge smokers to switch to e-cigs for big health gains – Reuters (free) AND E-cigarettes ‘should be on prescription’ – BBC News (free) AND Doctors should encourage smokers to switch to vaping – OnMedica (free)

See related report recently released by the National Academies of Sciences, Engineering, and Medicine (free report and commentaries)

 

4 – Effect of an In-Hospital Multifaceted Clinical Pharmacist Intervention on the Risk of Readmission: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Clinical Pharmacist Intervention Can Reduce ED Visits and Hospital Readmissions – MedicalResearch.com (free) AND Pharmacist-led extended medication review and follow-up on discharge may decrease risk of readmission – 2 Minute Medicine (free)

 

5 – EAU Guidelines on Assessment and Nonsurgical Management of Urinary Incontinence – European Urology (free)

 

6 – AASLD guidelines for the treatment of hepatocellular carcinoma – Hepatology (free)

 

7 – Richard Lehman’s journal review, 5 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – How Fake Surgery Exposes Useless Treatments – Scientific American (free)

Related: Sham surgeries: A tale of medical reversals & the role of the media – HealthNewsReview (free)

 

9 – To eat or to breathe? The answer is both! Nutritional management during noninvasive ventilation – Critical Care (free)

 

10 – Origins of the current outbreak of multidrug-resistant malaria in southeast Asia: a retrospective genetic study – The Lancet Infectious Diseases (free)

Commentaries: Drug-resistant malaria spreading fast in Southeast Asia – CIDRAP (free) AND Drug-resistant malaria will spread without urgent action, experts warn – The Guardian (free) AND Multidrug resistant malaria spread under the radar for years in Cambodia – Wellcome Sanger Institute (free)

 


 

1 – Recommended Immunization Schedule for Adults Aged 19 Years or Older, United States, 2018 – Annals of Internal Medicine (free)

 

2 – Viewpoint: Vitamin and Mineral Supplements: What Clinicians Need to Know – JAMA Internal Medicine (free for a period)

 

3 – Effect of Hot Tea Consumption and Its Interactions With Alcohol and Tobacco Use on the Risk for Esophageal Cancer: A Population-Based Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Hot tea tied to higher cancer risk for smokers and drinkers – Reuters (free) AND Very hot tea can raise risk of oesophageal cancer, suggests study – The Guardian (free) AND Hot Tea and Increased Risk for Esophageal Cancer – Medscape (free registration required)

 

4 – Social exclusion heightens risk of death across many health conditions – NIHR Signal (free)

Original Article: Morbidity and mortality in homeless individuals, prisoners, sex workers, and individuals with substance use disorders in high-income countries: a systematic review and meta-analysis – The Lancet (free) AND Commentary: Inclusion health: addressing the causes of the causes (free) AND Review: What works in inclusion health: overview of effective interventions for marginalised and excluded populations (free registration required)

 

5 – Risk of pre-eclampsia in women taking metformin: a systematic review and meta-analysis – Diabetic Medicine (link to abstract – $ for full-text)

Source: ACP Journal Wise ($)

“Metformin was associated with lower gestational weight gain and a lower risk of pre-eclampsia compared with insulin”

 

6 – Heparin-Induced Thrombocytopenia in the Patient Who Is Critically Ill – Chest (free)

Source: Critical Care Reviews Newsletter

 

7 – Richard Smith: Doctors and patients heading in opposite directions – The BMJ Opinion (free)

“Patients increasingly have multiple conditions, while doctors continue remorseless specialisation and subspecialisation. What are the consequences of this divergence?” (via @bmj_latest see Tweet)

 

8 – Hydroxyethyl-starch solutions (HES) should no longer be used in patients with sepsis or burn injuries or in critically ill patients – European Medicines Agency (free)

Press release: Hydroxyethyl-starch solutions for infusion to be suspended (free)

Source: EMA calls for hydroxyethyl starch solutions to be taken off market – The BMJ News ($)

 

9 – 5 ways poorly thought out health IT can worsen patient safety – KevinMD.com (free)

 

10 – Use of social media is associated with short sleep duration in a dose–response manner in students aged 11 to 20 years – Acta Paediatrica (link to abstract – $ for full-text)

Commentary: Social media use linked to lack of sleep in students – Wiley, via EurekAlert (free)

See also a recent Pediatrics supplement: Children, Adolescents and Screens: What We Know and What We Need To Learn (series of free articles) and related articles on Social Media and Mental Health

 


 

1 – World Cancer Day (4 February 2018) – World Health Organization (free)

New Document: Guide to cancer early diagnosis – World Health Organization (free)

News Release: Guide to Cancer Early Diagnosis (free)

See other key cancer documents by WHO

 

2 – Intrauterine Growth Restriction. Guideline of the German Society of Gynecology and Obstetrics – Geburtshilfe und Frauenheilkunde (free)

 

3 – BSH Guideline: management of thrombotic and haemostatic issues in paediatric malignancy – British Journal of Haematology (free)

 

4 – D-dimer Predicts Long-Term Cause-Specific Mortality, Cardiovascular Events and Cancer in Stable Coronary Heart Disease Patients: The LIPID Study – Circulation (link to abstract – $ for full-text)

Commentary: D-dimer Predicts Long-Term Mortality, Vascular Events, Cancer – American College of Cardiology, Latest in Cardiology (free) AND D-Dimer Predicts CV, Cancer Mortality Over 16 Years in Patients With Stable CHD – Medscape (free registration required)

 

5 – Proton Pump Inhibitors: Review of Emerging Concerns – Mayo Clinic Proceedings (free)

Related reviews: Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free) AND Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free)

Related guideline: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)

 

6 – Pediatrics Supplement – Congenital Zika Syndrome (via @greg_folkers)

– Public Health Approach to Addressing the Needs of Children Affected by Congenital Zika Syndrome (free)

– Zika and Public Health: Understanding the Epidemiology and Information Environment (free)

– Development of Infants With Congenital Zika Syndrome: What Do We Know and What Can We Expect? (free)

– Ophthalmologic Manifestations Associated With Zika Virus Infection (free)

– Motor Abnormalities and Epilepsy in Infants and Children With Evidence of Congenital Zika Virus Infection (free)

– The Likely Impact of Congenital Zika Syndrome on Families: Considerations for Family Supports and Services (free)

 

7 – One Day Your Mind May Fade. At Least You’ll Have a Plan – The New York Times (10 articles per month are free)

Free download: Health Directive for Dementia (free PDF) from Advanced Directive for Dementia

Source: New document allows advance planning for dementia – Univadis (free registration required)

“A Simple Way to Document the Medical Care You Would Want If You Had Dementia”

 

8 – A revolution in health care is coming – The Economist (a few articles per month are free) (via @equitylist)

“Welcome to Doctor You”

 

9 – A Multicomponent, Preschool to Third Grade Preventive Intervention and Educational Attainment at 35 Years of Age – JAMA Pediatrics (free)

Commentaries: Longer Early Childhood Intervention Linked To Greater Post-Secondary Attainment – MedicalResearch.com (free) AND Does Preschool Make a Long-Term Difference? – MedPage Today (free) AND Graduates of early childhood program show greater educational gains as adults – EurekAlert (free)

 

10 – Prevalence of Pulmonary Embolism in Patients With Syncope – JAMA Internal Medicine (free for a period)

Author Interview: Prevalence of Pulmonary Embolism in Patients With Syncope (free)

Commentaries: Prevalence of PE Low for Patients Presenting to ER With Syncope – Physician’s Weekly (free) AND Study Finds Pulmonary Embolus Rarely the Cause of Syncope – MedicalResearch.com (free)

 


 

1 – Migraine and risk of cardiovascular diseases: Danish population based matched cohort study – The BMJ (free)

Editorial: Migraine and risk of cardiovascular disease (free)

Commentaries: Migraine Associated With Broad Range of CVD Diagnoses in Nationwide Study – TCTMD (free) AND Migraine Linked To Increased Risk of Stroke, AFib, PE and Cardiovascular Disease – MedicalResearch.com (free)

 

2 – High performance plasma amyloid-β biomarkers for Alzheimer’s disease – Nature (link to abstract – $ for full-text)

Commentaries: Expert reaction to biomarkers for amyloid-beta in Alzheimer’s disease – Science Media Centre (free) AND A Big Step toward a Blood Test for Alzheimer’s – Scientific American (free) AND Simple blood test spots dementia protein – Nature News (free) AND Alzheimer’s hope as scientists unveil blood test for early signs – The Guardian (free)

 

3 – Cardiovascular Disease and Breast Cancer: Where These Entities Intersect: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentaries: Breast cancer treatments may increase the risk of heart disease – AHA / ASA Newsroom (free) AND Heart group warns of cardiovascular risks after treatment for breast cancer – STAT (free)

 

4 – Intravenous antibiotics, administered over 3 hours, are linked to lower death rates in sepsis – NIHR Signal (free)

Original article: Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

5 – Early use of tranexamic acid reduces bleeding more effectively – NIHR Signal (free)

Original article: Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free) AND Invited Commentary: Tranexamic acid: is it about time? (free)

“It is now clearer that every 15-minute delay after the first hour can reduce survival by about 10%”.

 

6 – Metformin Treatment in Patients With Type 2 Diabetes and Chronic Kidney Disease Stages 3A, 3B, or 4 – Diabetes Care (link to abstract – $ for full-text)

Commentaries: How I learned to stop worrying and love metformin – NephJC (free) AND Adjusted-Dose Metformin Appears Safe in Patients With Type 2 Diabetes and Chronic Kidney Disease Stage 3 or 4 – PracticeUpdate (free registration required)

 

7 – Unnecessary Medical Care: More Common Than You Might Imagine – NPR Shots (free)

Original report: First, Do No Harm Calculating Health Care Waste in Washington State (free PDF)

Related commentary: When Evidence Says No, but Doctors Say Yes – The Atlantic (free)

 

8 – Technology: Amazon Wants to Disrupt Health Care in America. In China, Tech Giants Already Have – The New York Times (10 articles per month are free)

 

9 – Medical Education: Bringing medicine back to the bedside – ACP Internist (free)

 

10 – History of Childhood Kidney Disease and Risk of Adult End-Stage Renal Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Childhood Kidney Disease and Adult ESRD (free)

Commentaries: History of Childhood Kidney Disease Linked to Risk of ESRD – Physician’s Weekly (free) AND Childhood Kidney Disease Predicts Adult ESRD – MedPage Today (free registration required)

 


 

1 – Catheter Ablation for Atrial Fibrillation with Heart Failure – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Catheter ablation better than pharmacological atrial fibrillation therapies – University of Utah Health, via EurekAlert (free)

“In patients w/heart failure & atrial fibrillation, catheter ablation lowers rate of death and hospitalization for worsening HF vs. medical therapy”. (via @NEJM see Tweet)

 

2 – Guideline: Diagnosis and management of gastrointestinal complications in adult cancer patients – German Society of Hematology and Medical Oncology (free)

 

3 – Associations of Omega-3 Fatty Acid Supplement Use With Cardiovascular Disease Risks: Meta-analysis of 10 Trials Involving 77 917 Individuals – JAMA Cardiology (free)

Commentary: Omega-3 Supplements Don’t Protect Against Heart Disease – The New York Times (10 articles per month are free)

Omega-3 fatty acids did not prevent fatal or nonfatal coronary heart disease or any major vascular events.

 

4 – New Series on malaria in pregnancy – The Lancet Infectious Diseases (via @Onisillos)

Homepage

Comment: Putting malaria in pregnancy back in the spotlight (free registration required)

Article 1: Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem (free registration required)

Article 2: Prevention of malaria in pregnancy (free registration required)

Article 3: Treatment of uncomplicated and severe malaria during pregnancy (free registration required)

 

5 – Traumatic brain injury and the risk of dementia diagnosis: A nationwide cohort study – PLOS One (free)

Commentaries: TBI is associated with increased dementia risk for decades after injury – PLOS, via ScienceDaily (free) AND More evidence traumatic brain injuries raise later dementia risk – Reuters (free)

“Using longitudinal, case-control, and sibling-matched analyses of nationwide data from Sweden, Peter Nordström & Anna Nordström describe the association between TBI and dementia, its time course, and the influence of familial factors”. (via @PLOSMedicine see Tweet)

 

6 – Pro/Con Debate – two doctors with opposite views on physician-assisted death:

Pro: I’m a doctor with end-stage cancer. I support medical aid in dying – STAT (free)

Con: Physician-assisted suicide won’t atone for medicine’s ‘original sin’ – STAT (free)

 

7 – Clinical Cancer Advances 2018: Annual Report on Progress Against Cancer from the American Society of Clinical Oncology (free)

Commentary: CAR T-Cell Immunotherapy Named Advance of the Year in ASCO’s Clinical Cancer Advances 2018 – The ASCO Post (free)

 

8 – CAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free)

Related reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 

9 – Treatment of Malignant Pleural Mesothelioma: American Society of Clinical Oncology Clinical Practice Guideline – Journal of Clinical Oncology (free)

Commentaries: ASCO Guideline Offers Recommendations for Management of Mesothelioma – Cancer Network (free) AND ASCO Releases First Mesothelioma Guideline – MedPage Today (free registration required)

 

10 – CDC Offers Refresher on Safe-sleep Practices for Infants – American Academy of Family Physicians (free)

Report: Vital Signs: Trends and Disparities in Infant Safe Sleep Practices, United States, 2009–2015 – Morbidity and Mortality Weekly Report (MMWR), CDC (free)

Related Guideline: SIDS and Other Sleep-Related Infant Deaths: Updated 2016 Recommendations for a Safe Infant Sleeping Environment – Task Force on Sudden Infant Death Syndrome, American Academy of Pediatrics (free)

 


 

1 – Screening for Lung Cancer: CHEST Guideline and Expert Panel Report (free PDF)

Summary and commentary: New guideline released on lung cancer screening – ACP Internist (free)

 

2 – HbA1c, diabetes and cognitive decline: the English Longitudinal Study of Ageing – Diabetologia (free)

Commentaries: The Startling Link Between Sugar and Alzheimer’s – The Atlantic (free) And Study Shows Long-Term Effects Of Diabetes And Prediabetes On The Brain – Forbes (free) AND New research shows diabetes and worse blood sugar control are associated with long-term cognitive decline – MedicalXpress (free) AND HbA1c Levels in Diabetes Linked to Cognitive Decline – Medscape (free registration required)

 

3 – Viewpoint: Does Medicine Overemphasize IQ? – JAMA (free)

 

4 – Global surveillance of trends in cancer survival 2000–14 (CONCORD-3): analysis of individual records for 37 513 025 patients diagnosed with one of 18 cancers from 322 population-based registries in 71 countries – The Lancet (link to abstract – $ for full-text)

Commentaries: What’s the 5-Year-Survival Rate For Cancer Patients Around The World? – NPR (free) AND Global improvement in cancer survival but international differences are still very wide – eCancer News (free)

 

5 – Periodontal Disease Assessed Using Clinical Dental Measurements and Cancer Risk in the ARIC Study – JNCI: Journal of the National Cancer Institute (free)

Commentaries: More evidence of link between severe gum disease and cancer risk – eCancer News (free) AND Evidence mounts of link between severe gum disease and various cancers – eCancer News (free) AND Severe Gum Disease Increases Both Cancer Risk and Mortality – Medscape (free registration required)

 

6 – Mid- and Long-Term Health Risks in Living Kidney Donors: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Analysis looks at long-term risks of living kidney donation – American College of Physicians, via EurekAlert (free) AND What Are The Health Risks To Living Kidney Donors? – MedicalResearch.com (free) AND Living kidney donors have low but elevated risk of renal failure – Reuters (free)

 

7 – Opinion: Pay for performance: a dangerous health policy fad that won’t die – STAT (free)

See related articles and commentaries on recent studies with disappointing results of P4P Programs

 

8 – Ministry of Health Clinical Practice Guidelines: Hypertension – Singapore Medical Journal (free PDF)

 

9 – Recommendations on the Use of Ultrasound Guidance for Adult Thoracentesis: A Position Statement of the Society of Hospital Medicine – Journal of Hospital Medicine (free)

 

10 – Safety of hydroxyanthracene derivatives for use in food – EFSA Journal (free)

Press release: EFSA confirms health concerns for hydroxyanthracene derivatives in food – European Food Safety Agency (free)

Commentary: Europe’s safety watchdog says laxatives may increase cancer risk – Reuters (free)

“This group of substances naturally occurs in plants such as aloe or senna species. Extracts containing them are used in food supplements for their laxative effect”. (from Press Release)

 


 

1 – Report: Global Antimicrobial Resistance Surveillance System (GLASS) – World Health Organization (free PDF)

News Release: High levels of antibiotic resistance found worldwide, new data shows (free)

Commentaries: WHO releases its first report on global antibiotic resistance – CIDRAP (free) AND UN health agency finds high levels of antibiotic resistance to world’s most common infections – UN News Centre (free)

 

2 – Editorial: Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) (via @MaryDixonWoods)

“Broadly, overdiagnosis means making people patients unnecessarily, by identifying problems that were never going to cause harm or by medicalising ordinary life experiences through expanded definitions of diseases”.

 

3 – Diagnosis and management of congenital diaphragmatic hernia: a clinical practice guideline – Canadian Medical Association Journal (free)

 

4 – Shorter Versus Longer Courses of Antibiotics for Infection in Hospitalized Patients: A Systematic Review and Meta-Analysis – Journal of Hospital Medicine (free PDF)

Source:  Hospital Medicine Virtual Journal Club

 

5 – Birth Defects Potentially Related to Zika Virus Infection During Pregnancy in the United States – JAMA (free for a period)

Commentaries: Birth defects climb in US areas with local Zika – CIDRAP (free) AND More birth defects in U.S. areas with Zika: U.S. health officials – Reuters (free)

 

6 – Increased risk of ischemic heart disease, hypertension, and type 2 diabetes in women with previous gestational diabetes mellitus, a target group in general practice for preventive interventions: A population-based cohort study – PLOS One (free)

Commentaries: Women who have gestational diabetes in pregnancy are at higher risk of future health issues – University of Birmingham, via ScienceDaily (free) AND Target Patients With Gestational Diabetes After Birth to Reduce Risks – Medscape (free registration required)

Related article and commentaries: Association of History of Gestational Diabetes With Long-term Cardiovascular Disease Risk

 

7 – Association of Exposure to Communities With Higher Ratios of Obesity with Increased Body Mass Index and Risk of Overweight and Obesity Among Parents and Children – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Your Neighbors, Your Waistline – New York Times (10 articles per month are free) AND Is ‘Social Contagion’ at Play When It Comes to Obesity Risk? – MedPage Today (free registration required) AND Location of military assignment tied to obesity risk for families – Cardiovascular Business (free)

 

8 – Richard Lehman’s journal review, 29 January 2018 – The BMJ Opinion (free)

 

9 – WSES guidelines for the management of iatrogenic colonoscopy perforation – World Journal of Emergency Surgery (free)

 

10 – EULAR recommendations for the use of imaging in large vessel vasculitis in clinical practice – Annals of Rheumatic Diseases (free)

 


 

1 – Guideline: Sore throat (acute): antimicrobial prescribing – National Institute for Health and Care Excellence (NICE) (free)

News release: Use paracetamol to relieve a sore throat rather than antibiotics (free)

Commentaries: GPs should cut back on antibiotic prescriptions for sore throats, NICE says – GP (free) AND ‘Painkillers best option for sore throats’ say new NHS guidelines – NHS Choices (free)

Related guideline: Corticosteroids for sore throat – The BMJ (free)

 

2 – British Association of Dermatologists’ guidelines for the investigation and management of generalized pruritus in adults without an underlying dermatosis, 2018 – British Journal of Dermatology (free)

 

3 – Association of parental supply of alcohol with adolescent drinking, alcohol-related harms, and alcohol use disorder symptoms: a prospective cohort study – The Lancet Public Health (free)

Commentaries: Parental supply and alcohol-related harm in adolescence: emerging but incomplete evidence – The Lancet Public Health (free) AND Expert reaction to study looking at parents giving alcohol to their teenage children, and alcohol-related risks – Science Media Centre (free) AND Parental provision of alcohol to teenagers does not reduce risks, compared to no supply, Australian study finds – ScienceDaily (free)

 

4 – Association Between Fluid Balance and Outcomes in Critically Ill Children: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a period)

Commentaries: Fluid Overload Boosts Mortality in Critically Ill Children – Medscape (free registration required)

 

5 – New series published to support the use of qualitative research in decision-making – World Health Organization (free) (via @olibiermann and @trishgreenhalgh)

The Series: Applying GRADE-CERQual to Qualitative Evidence Synthesis Findings – Implementation Science (free)

WHO Media Centre: Why is this new qualitative research tool (GRADE-CERQual) important? (free)

 

6 – Key Concepts for Informed Health Choices: a framework for helping people learn how to assess treatment claims and make informed choices – BMJ Evidence-Based Medicine (free) (via @Students4BE)

Related free resources: Testing Treatments Interactive AND Students 4 Best Evidence – Key Concepts

 

7 – Review: The incidental thyroid nodule – CA: A Cancer Journal for Clinicians (free)

 

8 – Current Approaches to Epistaxis Treatment in Primary and Secondary Care – Deutsches Ärzteblatt international (free)

 

9 – In the Land of the Skinny, People are Getting Fat – The New York Times (10 articles per month are free)

Related report: Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free) AND Editorial: Global Health Effects of Overweight and Obesity (free)

Related commentaries: Obesity now kills more people worldwide than car crashes, terror attacks, and Alzheimer’s combined – VOX (free) AND Global cost of obesity-related illness to hit $1.2tn a year from 2025 – The Guardian (free)

 

10 – A surgical procedure for shoulder pain is less effective than previously thought – NIHR Signal (free)

Original article: Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial – The Lancet (free) AND Editorial: No benefit of arthroscopy in subacromial shoulder pain (free)

 


 

1 – Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Myocardial Infarction after Influenza Infection (free)

Commentaries: Flu infection raises risk of heart attack in week after diagnosis – STAT (free) AND Flu Virus Can Trigger A Heart Attack – NPR (free) AND Flu increases the risk of heart attack – Reuters (free)

The researchers identified a six-fold increased risk of heart attack in the 7 days after a flu diagnosis.

 

2 – Low cigarette consumption and risk of coronary heart disease and stroke: meta-analysis of 141 cohort studies in 55 study reports – The BMJ (free)

Editorial: Just one cigarette a day seriously elevates cardiovascular risk (free)

Commentaries: CHD and stroke risk seriously elevated with just one daily cigarette – OnMedica (free) AND Smoking Even One Cigarette a Day Raises Cardiovascular Risk – Medscape (free registration required) AND Smoking Just One Cigarette a Day Carries Substantial Risks – Physician’s First Watch (free)

 

3 – Guideline: Duration of Contact Precautions for Acute-Care Settings – Society for Healthcare Epidemiology of America (SHEA) (free)

Summary and commentary: New guidelines issued on contact precautions for C. diff, resistant infections – ACP Hospitalist (free)

 

4 – Guideline: International technical guidance on sexuality education: An evidence-informed approach – UNESCO (free PDF)

News release: UN urges Comprehensive Approach to Sexuality Education – UNESCO (free)

Commentary: UN issues more progressive guidelines on sex education – Devex (free)

 

5 – Association of Resting Heart Rate and Temporal Changes in Heart Rate With Outcomes in Participants of the Atherosclerosis Risk in Communities Study – JAMA Cardiology (free)

Commentaries: Heart Rate Changes Over Time Hint at Higher Cardiovascular Risk – TCTMD (free) AND Increasing Heart Rate Over Time May Predict CV Events – MedPage Today (free registration required)

 

6 – Existing and potential infection risk zones of yellow fever worldwide: a modelling analysis – The Lancet Global Health (free)

 

7 – Long-term risks and benefits associated with cesarean delivery for mother, baby, and subsequent pregnancies: Systematic review and meta-analysis – PLOS Medicine (free)

Commentaries: Caesarean section versus natural birth – an obstetrician examines a new review  – The Conversation (free) AND Expert reaction to review paper looking at long-term risks and benefits of caesarean sections – Science Media Centre (free) AND C-sections linked to long-term risks and benefits – PLOS, via EurekAlert (free) AND Long-term risks and benefits of C-section revealed – Medical News Today (free)

As a scientist, I can appreciate the effort made in conducting a systematic review on the topic, but as an obstetrician I worry that the results can be over-interpreted by patients – not to mention obstetricians and midwives – and caesarean section “marketed” as a safe way to avoid pelvic floor problems”. (from The Conversation)

 

8 – Preoperative physiotherapy for the prevention of respiratory complications after upper abdominal surgery: pragmatic, double blinded, multicentre randomised controlled trial – The BMJ (free)

Commentaries: Pre-surgery breathing physio halves risk of complications – OnMedica (free) AND Respiratory Training Before Surgery Significantly Reduces Risk of Postoperative Lung Complications – Medindia (free) AND Breath Training Before Surgery Halves Postoperative Pneumonia Risk – Medscape (free registration required)

 

9 – Cloning of Macaque Monkeys by Somatic Cell Nuclear Transfer – Cell (free)

Commentaries: These monkey twins are the first primate clones made by the method that developed Dolly – Science (free) AND First monkeys cloned with technique that made Dolly the sheep – Nature (free) AND How afraid of human cloning should we be? – The Guardian (free)

 

10 – Projections of multi-morbidity in the older population in England to 2035: estimates from the Population Ageing and Care Simulation (PACSim) model – Age and Ageing (free)

Commentaries: Number of older people with four or more diseases will double by 2035 – OnMedica (free) AND Number of older people with four or more diseases will double by 2035 – Newcastle University (free) AND We’ll live longer but suffer more ill-health by 2035, says study – The Guardian (free)

See related articles and commentaries on Designing Health Care Systems for Patients with Complex Needs (free)

 


 

1 – 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association (free PDF)

Commentaries: More stroke patients eligible for crucial treatments under new guidelines – American Heart Association News (free) AND More stroke patients may receive crucial treatments under new guideline – AHA/ASA Newsroom (free)

A new guideline for treating acute ischemic stroke recommends an increased treatment window for mechanical clot removal from six hours to up to 24 hours in certain patients with clots in large vessels”. (from AHA/ASA Newsroom)

 

2 – Thrombectomy for Stroke at 6 to 16 Hours with Selection by Perfusion Imaging – New England Journal of Medicine (free)

Commentaries: Brain-scan guided emergency stroke treatment can save more lives – NIH News Releases (free) AND Study confirms late clot extraction can save brain cells of stroke victims – Reuters (free) AND New Findings Could Save Lives of More Stroke Patients – The New York Times (10 articles per month are free)

Related article: Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct – New England Journal of Medicine (link to abstract – $ for full-text)

 

3 – Perspectives: To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians (free)

Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free)

 

4 – Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus – JAMA Neurology (free for a period)

Editorial: Time May Be of the Essence in the Treatment of Pediatric Patients With Refractory Convulsive Status Epilepticus (free)

Commentary: Delays Raise Death Risk in Kids with Status Epilepticus – MedPage Today (free registration required)

“These findings may change the perception of acute seizure and status epilepticus treatment, tentatively converting it into an extremely time-sensitive emergency that is similar to stroke or other cardiovascular events”.

 

5 – Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline – Canadian Family Physician (free)

Related: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)

 

6 – ECTRIMS/EAN guideline on the pharmacological treatment of people with multiple sclerosis – European Journal of Neurology (free)

 

7 – Guideline: Oesophago-gastric cancer: assessment and management in adults – National Institute for Health and Care Excellence (NICE) (free)

 

8 – Guideline: Age-related macular degeneration – National Institute for Health and Care Excellence (NICE) (free)

 

9 – Association Between Left Atrial Appendage Occlusion and Readmission for Thromboembolism Among Patients With Atrial Fibrillation Undergoing Concomitant Cardiac Surgery – JAMA (free)

Commentaries: Largest Study to Date Supports Surgical LAA Closure in A-fib Patients – TCTMD (free) AND Thromboembolism Less Likely With LAA Closure Added to Cardiac Surgery – MedPage Today (free registration required)

Randomized trials are needed to confirm these interesting findings. 

 

10 – Trends in Survival After In-Hospital Cardiac Arrest During Nights and Weekends – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Survival From In-Hospital Cardiac Arrest Improves But Still Worse on Nights and Weekends – MedicalResearch.com (free)

AND Hospital patients less likely to survive ‘off-hours’ cardiac arrest – Reuters (free) AND You are still more likely to die in a hospital on the weekend – CNN (free)

See also a recent meta-analysis showing the “weekend effect” in surgical patients

 


 

1 – Report: Public Health Consequences of E-Cigarettes – National Academies of Sciences, Engineering, and Medicine (free PDF)

Press release: New Report One of the Most Comprehensive Studies on Health Effects of E-Cigarettes; Finds That Using E-Cigarettes May Lead Youth to Start Smoking, Adults to Stop Smoking (free)

Commentaries: E-Cigarettes Likely Encourage Kids To Try Tobacco But May Help Adults Quit – NPR (free) AND 4 big takeaways from the most comprehensive report on e-cigarettes yet – VOX (free) AND Vaping Can Be Addictive and May Lure Teenagers to Smoking, Science Panel Concludes – The New York Times (10 articles per month are free)

  

2 – Development and validation of outcome prediction models for aneurysmal subarachnoid haemorrhage: the SAHIT multinational cohort study – The BMJ (free)

See prognostic calculator: Prediction models for 3 month outcome after aSAH

 

3 – Antithyroid Drugs and Congenital Malformations: A Nationwide Korean Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: First trimester exposure to antithyroid drugs associated with increased risk of birth defects – 2 Minute Medicine (free) AND Use of Antithyroid Drugs Early in Pregnancy Tied to Birth Defect Risk – Physician’s First Watch (free) AND First trimester exposure to antithyroid drugs linked with birth defects – OnMedica (free)

 

4 – Advocacy for Improving Nutrition in the First 1000 Days To Support Childhood Development and Adult Health – Pediatrics (free)

Commentary: AAP Issues Recommendations for Improving Early-Childhood Nutrition – Physician’s First Watch (free) AND These Are the Best Foods for a Baby’s Brain – TIME (free)

 

5 – Robust research needs many lines of evidence – Nature (free)

 

6 – Parkinson’s disease in the ED: a potpourri of hyperpyrexia, dyskinesias, psychosis, and autonomic dysfunction – emDocs (free)

 

7 – Management of severe community acquired pneumonia in the emergency department – Journal of Emergency Medicine and Critical Care (free)

Source: Critical Care Reviews Newsletter

 

8 – Choosing Wisely Campaign: American Society of Breast Surgeons – Benign Breast Disease: Five Things Physicians and Patients Should Question (free)

Commentary: Choosing Wisely: 5 Procedures to Avoid in Benign Breast Disease – Physician’s First Watch (free)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

 

9 – Reduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy: A Randomized Controlled Trial – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Propranolol May Help Patients With PTSD – Psychiatric News Alert (free) AND Propranolol May Fill ‘Dire’ Treatment Need for PTSD – Medscape (free registration required)

 

10 – Starting antiretroviral therapy immediately after HIV diagnosis reduces transmission of the virus – NIHR Signal (free)

Original article: Implications for a policy of initiating antiretroviral therapy in people diagnosed with human immunodeficiency virus: the CAPRA research programme – Programme Grants for Applied Research (free)

 


 

1 – Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Hyperthermic intraperitoneal chemotherapy with surgery increases survival for epithelial ovarian cancer patients – 2 Minute Medicine (free) AND Add-On Hyperthermic Intraperitoneal Chemotherapy Assessed in Ovarian CA – MPR (free)

Patients treated with hyperthermic intraperitoneal chemotherapy associated with surgery had increased median overall survival compared to patients treated with surgery alone (45,7 months vs 33,9 months).

 

2 – Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults: Synopsis of the 2017 American College of Cardiology/American Heart Association Hypertension Guideline – Annals of Internal Medicine (free)

Related: Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free) AND AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free)

 

3 – Clinical guideline and recommendations on pre-operative exercise training in patients awaiting major non-cardiac surgery – Anaesthesia (free)

 

4 – Review: Treatment of anxiety disorders – Dialogues in Clinical Neuroscience (free)

 

5 – Review: Update on the management of venous thromboembolism – Cleveland Clinic Journal of Medicine (free)

 

6 – Tracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials – Critical Care (free) (via @fpereirapa)

 

7 – Non-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy? – Journal of General Internal Medicine (free for a period)

Related: Challenges in the Design and Interpretation of Noninferiority Trials – New England Journal of Medicine (free) AND Users’ guide to the surgical literature: how to assess a noninferiority trial – Canadian Journal of Surgery (free)

 

8 – Richard Lehman’s journal review, 22 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – The Right Place at the Right Time: Medical Oncology Outpatients’ Perceptions of Location of End-of-Life Care – JNCCN (free)

Commentary: Let’s Talk About End-of-Life Care – National Comprehensive Cancer Network, via NewsWise (free)

“…majority of people with cancer would like their physicians to ask them where they would prefer to receive end-of-life care” (from NewsWise).

 

10 – Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services – Prehospital Emergency Care (free)

Commentaries in the same issue: Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services: A Significant Step Forward and a Model for Other High-Risk Industries (free) AND What an Evidence-based Guideline for Fatigue Risk Management Means for Us: Statements From Stakeholders (free) AND Proposed Performance Measures and Strategies for Implementation of the Fatigue Risk Management Guidelines for Emergency Medical Services (free) AND Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services: A Step in the Right Direction Toward Better Sleep Health (free)

 


 

1 – Adjunctive Glucocorticoid Therapy in Patients with Septic Shock – New England Journal of Medicine (free)

Commentaries: The Definitive Word on Steroids in Septic Shock – Emergency Medicine Literature of Note (free) AND Adrenal – The Bottom Line (free)

“For the primary outcome, there was no statistically significance difference in mortality at 90 days – 27.9% in the hydrocortisone cohort, and 28.8% with placebo. Looking at secondary outcomes, the results here tended to favor hydrocortisone – a slightly faster resolution of shock, shorter ICU stays, and, oddly, decreased transfusion requirements”. (from Emergency Medicine Literature of Note Blog)

 

2 – Critical Care Reviews Book 2018 (free PDF)

“The Critical Care Reviews Book summarizes, critiques and puts in context the biggest trials of the year”.

 

3 – Weekend Surgical Care and Postoperative Mortality: A Systematic Review and Meta-Analysis of Cohort Studies (free)

Commentary: Evidence Supports ‘Weekend Effect’ for Mortality after Surgery – Wolters Kluwer, via NewsWise (free)

“The odds of postoperative mortality were 27 percent higher for patients admitted to the hospital on Saturday or Sunday, compared to those hospitalized on a weekday” (from NewsWise).

  

4 – Women’s reproductive factors and incident cardiovascular disease in the UK Biobank – Heart (link to abstract – $ for full-text)

Commentaries: Starting periods before age of 12 linked to heightened risk of heart disease and stroke – The BMJ, via EurekAlert (free) AND Early periods linked to heightened cardiovascular risk – OnMedica (free) AND Starting periods early linked to health risks later in life – Medical News Today (free) AND Early menarche and menopause linked to cardiovascular disease risk – The Guardian (free)

 

5 – To improve global health, tax the things that are killing us – Financial Times (free)

Related: The Case for the Health Taxes – The New York Times (10 articles per month are free) AND Mexico and Hungary tried junk food taxes — and they seem to be working – VOX (free) AND Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian (free)

Related Policies, Guidelines and Commentaries (all free): Beverage consumption taxes on sugar-sweetened beverages AND The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities AND Fiscal policies for the prevention of diseases AND Reducing cardiovascular disease burden through targeted dietary policies

 

6 – Integrating new approaches to atrial fibrillation management: the 6th AFNET/EHRA Consensus Conference – EP Europace (free)

 

7 – Italian guidelines on the assessment and management of pediatric head injury in the emergency department – Italian Journal of Pediatrics (free)

 

8 – Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study – The BMJ (free)

“The duration of treatment rather than dose is more strongly associated with opioid misuse after surgery, concludes this study” (via @bmj_latest see Tweet)

 

9 – Infectious virus in exhaled breath of symptomatic seasonal influenza cases from a college community – Proceedings of the National Academy of Sciences (free)

Commentaries: Study confirms flu spreads by aerosols, not just coughs, sneezes – CIDRAP (free) AND Flu may be spread just by breathing, new UMD-led study shows – University of Maryland, via EurekAlert (free)

 

10 – Staying on antidepressants may prevent a relapse of anxiety – NIHR Signals (free)

Original article: Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)

 


 

1 – The 2017 Update of the German Clinical Guideline on Epidemiology, Diagnostics, Therapy, Prevention, and Management of Uncomplicated Urinary Tract Infections in Adult Patients: Part 1 – Karger, Urologia Internationalis (free) (via @CIDRAP_ASP see Tweet)

 

2 – Detection and localization of surgically resectable cancers with a multi-analyte blood test – Science (link to abstract – $ for full-text)

Commentaries: Simple blood test detects eight different kinds of cancer – Nature News (free) A new blood test can detect eight different cancers in their early stages – The Conversation (free) AND CancerSEEK: Blood Test That Detects Eight Common Cancers – Medscape (free registration required) AND Scientists Edge Closer To A Blood Test To Detect Cancers – NPR (free) And Blood test could use DNA to spot early-stage cancers, study shows – The Guardian (free)

 

3 – Perspective: Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free)

Related: AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free)

 

4 – Video: Pandemics – a worrying global public health threat (free) (via @RSTMH see Tweet)

Related: The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) AND Is It Possible to Predict the Next Pandemic? – The Atlantic (free) AND Stopping Pandemics Before They Start – The New York Times (10 articles per month are free)

 

5 – Single dose moxidectin versus ivermectin for Onchocerca volvulus infection in Ghana, Liberia, and the Democratic Republic of the Congo: a randomised, controlled, double-blind phase 3 trial – The Lancet (free)

Editorial: A new powerful drug to combat river blindness (free)

 

6 – Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women – JAMA Oncology (free)

Author interview: Dietary Inflammatory Potential and Risk of Colorectal Cancer in Men and Women (free)

Commentary: Why certain diets may increase your cancer risk – VOX (free)

 

7 – The Best Response to Medical Errors? Transparency – AAMC News (free)

Related: The Michigan Model: Medical Malpractice and Patient Safety at UMHS (free)

 

8 – Patient reminder and recall interventions to improve immunization rates – Cochrane Library (link to abstract – $ for full-text)

Commentaries: Boosting vaccination rates with reminders: new Cochrane evidence – Evidently Cochrane (free) AND Sending out reminders/recalls can drive up immunisation rates – OnMedica (free) AND Patient Reminders Improve Vaccination Rates in Primary Care – Physician’s First Watch (free)

 

9 – Video: Early Palliative Care: a video for health and care professionals – University of Edinburgh (free) (via @OUPMedicine see Tweet)

Related: Early palliative care for adults with advanced cancer – Cochrane Library (free summary and original article) AND How Early Palliative Care May Benefit Patients With Incurable Cancer – ASCO Post (free)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

10 – Prescribing Cascade in a Cardiology Practice – American College of Cardiology, Latest in Cardiology (free)

“Before starting a medication to treat a new medical condition, consider whether this condition could be a drug-related adverse event. Specifically, consider whether this could represent a prescribing cascade”.

 


 

1 – Household-Contact Investigation for Detection of Tuberculosis in Vietnam – The New England Journal of Medicine (free)

Quick Take Video Summary: Contact Investigation for Tuberculosis (free)

 

2 – Interventions to increase tuberculosis case detection at primary healthcare or community-level services – Cochrane Library (free)

Summary: Interventions to increase the number of tuberculosis cases being diagnosed – Evidently Cochrane (free)

Commentary: Cochrane review of effectiveness of strategies to improve access to treatment for TB – Liverpool School of Tropical Medicine, via EurekAlert (free)

 

3 – Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Monoclonal Gammopathy of Undetermined Significance: Risk for Progression to Cancer, Other Disorders Examined – Physician’s First Watch (free) AND Patients with blood cancer precursor at risk of developing cancer even after 30 years – Mayo Clinic, via EurekAlert (free)

 

4 – Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

“25 biases affecting evidence on health kick off the new @CebmOxford Catalog of Bias” (via @hildabast see Tweet)

 

5 – Identifying older adults at risk of harm following elective surgery: a systematic review and meta-analysis – BMC Medicine (free)

Commentary: Age itself is not a risk factor for complications after surgery among older patients – OnMedica (free)

“Q: What predicts poor outcome after elective surgery in older people?

A: Frailty, cognitive impairment, depression, smoking but NOT age per se”. (via @trishgreenhalgh see Tweet)

 

6 – Richard Smith: The corruption of medical language – The BMJ Opinion (free)

Related: It’s not just you: science papers are getting harder to read – Nature (free) ‘It’s time to make sure research is understandable to all’ – The Telegraph (free) AND Scientific language is becoming more informal – Nature (free)

“Too often, academic journals are filled with complex language and turgid prose, which is intended not to inform the reader but to ennoble the writer”. (via @bmj_latest see Tweet)

 

7 – Red and processed meat consumption and breast cancer: UK Biobank cohort study and meta-analysis – European Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Processed meat ‘cancer risk’ in older women – OnMedica (free) AND Consumption of processed meat may increase the risk of breast cancer, according to a new study – MedicalXpress (free)

 

8 – Review: What works in inclusion health: overview of effective interventions for marginalised and excluded populations – The Lancet (free registration required)

Related Article: Morbidity and mortality in homeless individuals, prisoners, sex workers, and individuals with substance use disorders in high-income countries: a systematic review and meta-analysis – The Lancet (free) AND Commentary: Inclusion health: addressing the causes of the causes (free)

 

9 – Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial – The Lancet (free)

Commentaries: Learning from TARDIS: time for more focused trials in stroke prevention – The Lancet (free) AND Triple Antiplatelets for Reducing Dependency After Ischaemic Stroke – TARDIS – American College of Cardiology, Latest in Cardiology (free)

“Among patients with recent cerebral ischaemia, intensive antiplatelet therapy did not reduce the incidence and severity of recurrent stroke or TIA, but did significantly increase the risk of major bleeding. Triple antiplatelet therapy should not be used in routine clinical practice”.

 

10 – Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non–Vitamin‐K Oral Anticoagulants (RAF‐NOACs) Study – Journal of the American Heart Association (free)

“Composite rates of recurrence and major bleeding were 12.4% in patients who initiated NOACs within 2 days after acute stroke, 2.1% in those who initiated NOACs between 3 and 14 days, and 9.1% in patients who initiated NOACs >14 days after acute stroke. Future randomized studies to assess timing of initiation and choice of agent in patients with acute stroke and AF are warranted”.

 


 

1 – Association of Bariatric Surgery Using Laparoscopic Banding, Roux-en-Y Gastric Bypass, or Laparoscopic Sleeve Gastrectomy vs Usual Care Obesity Management With All-Cause Mortality – JAMA (link to abstract – $ for full-text)

Commentaries: Bariatric Surgery Prolongs Lifespan in Obese – Northwestern University, via NewsWise (free) AND Obesity surgery ‘halves risk of death’ compared with lifestyle changes – The Guardian (free) AND Bariatric Tx Bests Usual Care for Long-Term Health – MedPage Today (free registration required)

 

2 – Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss at 5 Years Among Patients With Morbid Obesity: The SLEEVEPASS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Related article: Effect of Laparoscopic Sleeve Gastrectomy vs Laparoscopic Roux-en-Y Gastric Bypass on Weight Loss in Patients With Morbid ObesityThe SM-BOSS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Laparoscopic Gastric Sleeve Compared to Bypass Bariatric Surgery – RheumNow (free) AND No Clinical Significance in Weight Loss Among Sleeve Gastrectomy and Gastric Bypass Patients – AJMC (free) AND Weight-Loss Surgery Approaches Offer Similar Results – MedPage Today (free registration required) AND Rise of Sleeve Gastrectomy Is No Therapeutic Misadventure – Medscape (free registration required) AND Newer weight-reduction surgery effective, but may worsen acid reflux – Reuters (free)

 

3 – Association of Bariatric Surgery vs Medical Obesity Treatment With Long-term Medical Complications and Obesity-Related Comorbidities – JAMA (link to abstract – $ for full-text)

Commentaries: Bariatric Surgery for Obesity Reduces Some Risks, Raises Others – Medscape (free registration required)

 

4 – USPSTF Not Backing Ankle-Brachial Index, CRP, or Coronary Calcium – MedPage Today (free registration required) AND No Change in USPSTF’s Stance on Using Nontraditional Risk Factors to Assess CV Risk – Physician’s First Watch (free)

Draft Recommendation Statement 1: Cardiovascular Disease: Risk Assessment With Nontraditional Risk Factors – USPSTF (free)

Draft Recommendation Statement 2: Peripheral Artery Disease and Cardiovascular Disease: Screening and Risk Assessment With the Ankle-Brachial Index (free)

The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP), or coronary artery calcification (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.

 

5 – Adverse effects of caffeinated energy drinks among youth and young adults in Canada: a Web-based survey – CMAJ Open (free)

Commentaries: Over half of 12-24 year olds have side effects from energy drinks, survey reports – NHS Choices (free) AND Energy drinks can negatively impact health of youth – University of Waterloo, via ScienceDaily (free)

Related Position Statement: Energy and sports drinks in children and adolescents – Canadian Pediatric Society (free)

 

6 – Medical News & Perspectives: Interest in the Ketogenic Diet Grows for Weight Loss and Type 2 Diabetes – JAMA (free)

 

7 – Case Report: Snap, crackle and pop: when sneezing leads to crackling in the neck – BMJ Case Reports (free)

Commentaries: Man Ruptures His Throat By Stifling A Big Sneeze, Prompting Doctors’ Warning – NPR (free) AND Here Is What Can Happen If You Hold In A Sneeze – Forbes (free)

 

8 – Trial of Contralateral Seventh Cervical Nerve Transfer for Spastic Arm Paralysis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Swapping cervical nerves – Richard Lehman’s journal reviews (free) AND Nerve Transfer May Restore Function in Stroke Victims – MedPage Today (free registration required)

 

9 – FDA News Release: FDA acts to protect kids from serious risks of opioid ingredients contained in some prescription cough and cold products by revising labeling to limit pediatric use (free)

Commentaries: FDA strengthens warning on opioid cold medicine – CNN (free) AND FDA: Children should not take cough medicine with codeine – AAP News (free) AND FDA Updates Labeling for Opioid-Containing Medications to Limit Use in Children – Pharmacy Times (free) AND No Opioid Cough Meds in Children Under 18, FDA Says – Medscape (free registration required)

 

10 – Prevention of Hepatitis B Virus Infection in the United States: Recommendations of the Advisory Committee on Immunization Practices – Morbidity and Mortality Weekly Report (MMWR), CDC (free)

Commentary: ACIP: Updated Recommendations for Hepatitis B Virus Infection Prevention – MPR (free)

Related guideline and commentaries: Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice From the American College of Physicians and the Centers for Disease Control and Prevention

 


 

1 – European Resuscitation Council Guidelines for Resuscitation: 2017 update (free)

Source: Critical Care Reviews Newsletter

Related guidelines: 2017 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary – Resuscitation (free) 2017 American Heart Association Focused Update on Adult Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF) AND 2017 American Heart Association Focused Update on Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF)

 

2 – Editorial: The natural environment and emergence of antibiotic resistance – The Lancet Planetary Health (free)

Related reports: Combating Antimicrobial Resistance: A One Health Approach to a Global Threat – The National Academies Press (free PDF) AND Antimicrobial Resistance: Investigating the Environmental Dimension (free PDF) AND Tackling Drug-Resistant Infections Globally: final report and recommendations (free PDF)

 

3 – Effect of Changing Work Stressors and Coping Resources on the Risk of Type 2 Diabetes: The OHSPIW Cohort Study – Diabetes Care (link to abstract – $ for full-text)

Commentary: Increased stress at work linked to higher risk of diabetes – Reuters (free)

 

4 – Transfer of Fresh versus Frozen Embryos in Ovulatory Women – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Frozen vs. fresh embryos for IVF? Study finds little impact on fertility – Yale News (free) AND Frozen just as good as fresh embryo when it comes to success in IVF, study shows – The Sydney Morning Herald (free) AND Live-birth rates similar among ovulating women undergoing fresh- or frozen-embryo transfer – 2 Minute Medicine (free) AND Fresh Embryos as Good as Frozen Ones for In Vitro Fertilization – The New York Times (10 articles per month are free)

 

5 – Childhood trajectories of peer victimization and prediction of mental health outcomes in midadolescence: a longitudinal population-based study – Canadian Medical Association Journal (free)

Commentary: Teens who were severely bullied as children at higher risk of suicidal thoughts, mental health issue – CMAJ, via EurekAlert (free)

 

6 – Effect of the School-Based Telemedicine Enhanced Asthma Management (SB-TEAM) Program on Asthma Morbidity: A Randomized Clinical Trial – JAMA Pediatrics (free)

Commentaries: School-based telemedicine enhances asthma management in children – 2 Minute Medicine (free) AND For City Kids with Asthma, Telemedicine and In-School Care Cut ER Visits in Half – University of Rochester (free)

 

7 – Can Your Hip Replacement Kill You? – The New York Times (10 articles per month are free)

“Lawsuits are pulling back the curtain on what some doctors call the Wild West of medicine: the untested and largely unregulated medical device industry” (via @NYTHealth see Tweet)

 

8 – Amyotrophic lateral sclerosis – Nature Reviews Disease Primers (free)

 

9 – Richard Lehman’s journal review, 15 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

10 – Primary prophylaxis of invasive fungal infections in patients with haematological malignancies: 2017 update of the recommendations of the Infectious Diseases Working Party (AGIHO) of the German Society for Haematology and Medical Oncology (DGHO) (free)

 


 

1 – International guidelines for groin hernia management – HerniaSurge Group (free)

 

2 – Excerpt from the Canadian Ophthalmological Society evidence-based clinical practice guidelines for the management of diabetic retinopathy – Canadian Journal of Ophthalmology (free)

Commentary in: Clinical Practice Guidelines, December 2017 – Medscape (free registration required)

 

3 – Breast Implants and the Risk of Anaplastic Large-Cell Lymphoma in the Breast – JAMA Oncology (link to abstract – $ for full-text)

Commentaries: Breast Implants Associated With Increased Risk of Breast Anaplastic Large-cell Lymphoma – Oncology Nurse Advisor (free) AND Dutch Study Links Implants to Increased Breast-ALCL Risk – MedPage Today (free registration required)

 

4 – Editorial: Children and social media – The Lancet (free)

Original report: Life in ‘likes’ – Children’s Commissioner (free)

See also a recent Pediatrics supplement on Children, Adolescents and Screens (free articles) and other commentaries on Social Media and Mental Health (free articles)

 

5 – Reversing the Cardiac Effects of Sedentary Aging in Middle Age—A Randomized Controlled Trial: Implications For Heart Failure Prevention – Circulation (free PDF)

Commentaries: Exercise Study Hints at Volume, Intensity Levels Needed to Improve Cardiac Fitness in Middle Age – TCTMD (free) AND Exercise in middle age can reverse heart effects of sedentary lifestyle – Cardiovascular Business (free) AND Exercise May Reverse Negative Cardiac Effects of Sedentary Life – Medscape (free registration required) AND Exercise is good for you, but did this study actually show it can ‘reverse damage from heart aging’? – HealthNewsReview (free)

 

6 – How to Counter the Circus of Pseudoscience – The New York Times (10 articles per month are free)

Related: In 2018 we need less nonsense and more science – The Globe and Mail (free)

 

7 – What I’ve learned from my tally of 757 doctor suicides – The Washington Post (free)

Related: Why are doctors killing themselves? – MJA InSight (free) AND Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT (free) AND Protecting interns and other physicians from depression and suicide – STAT (free)

 

8 – Supporting Patients Through Serious Illness and the End of Life: Sutter Health’s AIM Model – The Commonwealth Fund (free)

“By proactively managing care for the terminally ill, the Advanced Illness Management program has produced savings of $8,000–$9,000 per patient” (via @commonwealthfnd see Tweet)

 

9 – Supported employment helps people with severe mental illness to obtain work – NIHR Signal (free)

Original article: Interventions for obtaining and maintaining employment in adults with severe mental illness, a network meta-analysis – Cochrane Library (link to abstract – $ for full-text)

 

10 – Antipsychotics and the Risk of Aspiration Pneumonia in Individuals Hospitalized for Nonpsychiatric Conditions – Journal of the American Geriatrics Society, via Medscape (free registration required)

Commentary: Antipsychotics May Increase Risk of Aspiration Pneumonia in Older Adults – Psychiatric News Alert (free)

Related: Antipsychotic use in elderly patients and the risk of pneumonia – Expert Opinion on Drug Safety (free) AND Antipsychotic drug exposure and risk of pneumonia: a systematic review and meta-analysis of observational studies – Pharmacoepidemiology & Drug Safety (free)

 


 

1 – Bioethics: 200th anniversary of Mary Shelley’s Frankenstein (selected free texts)

‘Frankenstein’ Reflects The Hopes And Fears Of Every Scientific Era – The Atlantic (Free) AND The Horror Story That Haunts Science: Two Hundred Years Later, Frankenstein still Shocks And Inspires – Science (free) AND Infographic: Creating a modern monster – Science (free) AND Taming the Monsters of Tomorrow – Science (free) AND Dr Frankenstein’s Bioethical Experiment – The Lancet (Free Registration Required)

 

2 – Subclinical device-detected atrial fibrillation and stroke risk: a systematic review and meta-analysis – European Heart Journal (free)

See related opinion and commentaries in Get Ready For A Tsunami Of ECGs

 

3 – Which stent is best for heart attacks? – Evidently Cochrane (free)

Original article: Drug-eluting stents versus bare-metal stents for acute coronary syndrome – Cochrane Library (free)

“The current review suggests that using DES rather than BMS may reduce the need for future coronary procedures but there is no evidence that it saves lives or reduces major cardiovascular events”.

 

4 – Attention-Deficit/Hyperactivity Disorder and Very Preterm/Very Low Birth Weight: A Meta-analysis – Pediatrics (free)

Commentaries: Premature Infants Particularly Vulnerable to ADHD – Psychiatric Times (free) AND ADHD and Early Experience: Revisiting the Case of Low Birth Weight – Pediatrics (free)

 

5 – Acid-Suppressive Drug Use During Pregnancy and the Risk of Childhood Asthma: A Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentaries: Antacids During Pregnancy Tied to Asthma in Children – The New York Times (10 articles per month are free) AND Is antacid use during pregnancy tied to childhood asthma? – Reuters (free)

 

6 – Prenatal exposure to acetaminophen and children’s language development at 30 months – European Psychiatry (link to abstract – $ for full-text)

Commentaries: Is acetaminophen really safe in pregnancy? – Medical News Today (free) AND Acetaminophen Use During Pregnancy Associated With Elevated Rate of Language Delay in Girls, Mount Sinai Researchers Find – Mount Sinai Health System, via NewsWise (free)

 

7 – Adherence to Mediterranean Diet Reduces Incident Frailty Risk: Systematic Review and Meta-Analysis – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Commentaries: Mediterranean diet may help protect older adults from becoming frail – Wiley, via ScienceDaily (free) AND Mediterranean Diet May Lessen Frailty Risk in Older Adults – Medscape (free registration required)

 

8 – A Mediterranean-style dietary intervention supplemented with fish oil improves diet quality and mental health in people with depression: A randomized controlled trial (HELFIMED) – Nutritional Neuroscience (free)

Commentaries: Mediterranean Diet Improves Mental Health, Study Finds – Mad in America (free) AND Mediterranean Diet Improves Depression – Mescape (free registration required)

 

9 – Cardiovascular Risk Factors After Adolescent Bariatric Surgery – Pediatrics (free)

Commentary: Bariatric Surgery Helps Teens With Severe Obesity Reduce Heart Disease Risk – NPR (free) AND Teens show decreased risk for heart disease later in life after bariatric surgery – Nationwide Children’s Hospital, via ScienceDaily (free)

 

10 – Risk of suicide and non-fatal self-harm after bariatric surgery: results from two matched cohort studies – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentary: Bariatric Surgery Associated with Higher Suicide Risk – Physician’s First Watch (free)

 


 

1 – The American Psychiatric Association Practice Guideline for the Pharmacological Treatment of Patients With Alcohol Use Disorder (free)

News release: APA Releases New Practice Guideline on Treatment of Alcohol Use Disorder – American Psychiatry Association (free)

Commentary: New Alcohol Use Disorder Guideline Emphasizes Medication – Medscape (free registration required)

 

2 – News Release: AAOS approves diagnostic and treatment criteria for osteoarthritis of the hip – American Academy of Orthopedic Surgeons (free)

See Apropriate Use Criteria: Management of Osteoarthritis of the Hip (free)

Related AAOS Guideline: Management of Osteoarthritis of the Hip (free PDF)

Commentary: AAOS: Non-Surgical Tx Best for Hip OA – MedPage Today (free registration required)

 

3 – Too much screening has misled us about real cancer risk factors, experts say – STAT (free) AND Overscreening for Cancer Yields Misleading Results – MedPage Today (free) AND Could finding more cancer lead us to understand risk factors less? – HealthNewsReview (free)

Original article: Scrutiny-Dependent Cancer and Self-fulfilling Risk Factors – Annals of Internal Medicine (link to abstract – $ for full-text)

 

4 – Opinion: The Less-Is-More Crusade — Are We Overmedicalizing or Oversimplifying? (free)

Commentaries rebutting the opinion: In Defense of Less-Is-More – Medscape (free registration required) AND Has “Less is More” gone too far? The New England Journal says it has – Lown Institute (free) AND Ms. Inappropriate Defends The Status Quo – Cardiobrief (free) AND Nuance And The Healthcare Apocalypse – Cardiobrief (free)

 

5 – Pharmacotherapy for obesity: What you need to know – Cleveland Clinic Journal of Medicine (free)

 

6 – How Big Tech is Going After Your Health Care – The New York Times (10 articles per month are free)

 

7 – Perspective: Evidence-Based Health Policy – New England Journal of Medicine (free)

 

8 – Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian (free)

Related: Beverage consumption taxes on sugar-sweetened beverages AND The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities AND Fiscal policies for the prevention of diseases AND Reducing cardiovascular disease burden through targeted dietary policies

 

9 – Association of Maternal Use of Folic Acid and Multivitamin Supplements in the Periods Before and During Pregnancy With the Risk of Autism Spectrum Disorder in Offspring – JAMA Psychiatry (free)

Commentaries: Use of Folic Acid and Multivitamins During Pregnancy May Lower Autism Risk – Psychiatry News Alert (free) AND Folic Acid, Multivitamins During Pregnancy May Cut ASD Risk – MedPage Today (free registration required) AND Are Vitamin Supplements Used Before or During Pregnancy Associated with Risk of Autism Spectrum Disorder? – The JAMA Network (free)

 

10 – Association of Folic Acid Supplementation During Pregnancy With the Risk of Autistic Traits in Children Exposed to Antiepileptic Drugs In Utero – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Lack of Folic Acid Supplements During Pregnancy Linked With Increased Autism Risk in Children Exposed to Seizure Drugs In Utero – Medical Research (free) AND Folic Acid in Pregnant Women on Antiepileptic Drugs Linked to Lower Autism Risk – Medscape (free registration required) AND Folic Acid May Limit Autism Traits in Children of Epileptic Women – MedPage Today (free registration required) AND Folic acid lessens autism risk for fetal anti-epileptic exposure – MedicalXpress (free)