Or

Open access

TOP 10 Medical News Stories

 

1 – Tracking Universal Health Coverage: 2017 Global Monitoring Report – Joint Report from the World Bank and the World Health Organization (free PDF)

Press Release: World Bank and WHO: Half the world lacks access to essential health services, 100 million still pushed into extreme poverty because of health expenses (free)

Infographic: Tracking Universal Health Coverage: 2017 Global Monitoring Report (free)

Commentaries: Healthcare costs are pushing millions into extreme poverty. This outrage must end – World Economic Forum (free) AND Almost 100 million people a year ‘forced to choose between food and healthcare’ – The Guardian (free)

 

2 – Is treatment with corticosteroids beneficial and safe for people with pneumonia? – The Cochrane Library (free)

Related: Corticosteroids for Pneumonia: Ready for Primetime? – emDocs (free)

“Corticosteroid therapy reduced mortality and morbidity in adults with severe CAP; the number needed to treat for an additional beneficial outcome was 18 patients (95% CI 12 to 49) to prevent one death. Corticosteroid therapy reduced morbidity, but not mortality, for adults and children with non-severe CAP”

 

3 – Estimates of global seasonal influenza-associated respiratory mortality: a modelling study – The Lancet (link to abstract – $ for full-text)

Commentaries: Respiratory diseases linked to seasonal flu claim thousands of lives every year – UN health agency (free) AND Up to 650 000 people die of respiratory diseases linked to seasonal flu each year – World Health Organization (free) AND CDC says more people die of influenza worldwide than some experts have estimated – PBS NewsHour (free)

 

4 – Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Exercise May Aid Parkinson’s Disease, but Make It Intense – The New York Times (10 articles per month are free) AND High-Intensity Exercise May Cut Parkinson’s Motor Symptoms – Medscape (free registration required) AND Vigorous Exercise May Hold Benefit in Early Parkinson’s – MedPage Today (free registration required) High-intensity exercise delays Parkinson’s progression – Northwestern University, via ScienceDaily (free)

 

5 – Associations between fast food and physical activity environments and adiposity in mid-life: cross-sectional, observational evidence from UK Biobank – The Lancet Public Health (free)

Commentaries: The built environment and obesity in UK Biobank: right project, wrong data? – The Lancet Public Health (free) AND Living near exercise facilities linked to lower BMI and smaller waists – OnMedica (free) Living near physical activity facilities linked to smaller waistline, lower BMI and lower body fat percentage – London School of Hygiene & Tropical Medicine (free)

 

6 – Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study – The Lancet Infectious Diseases (link to abstract – $ for full-text) (via @Onisillos)

Commentaries: Zika virus, not vaccine or insecticide, linked to birth defects in Brazil – STAT (free) AND Study bolsters Zika-microcephaly link, rules out others – CIDRAP (free)

 

7 – Healthcare-acquired infections: prevention strategies – Internal Medicine Journal (free)

Source: Hospital Medicine Virtual Journal Club

 

8 – Association Between Methylphenidate and Amphetamine Use in Pregnancy and Risk of Congenital Malformations: A Cohort Study From the International Pregnancy Safety Study Consortium – JAMA Psychiatry (free)

Editorial: Shedding Light on the Risks of Methylphenidate and Amphetamine in Pregnancy (free)

Commentary: ADHD med use during pregnancy and risk of birth defects – Brigham and Women’s Hospital, via ScienceDaily (free) AND Class of ADHD medication linked to increased risk of congenital heart defects – Cardiovascular Business (free)

“Researchers find small increase in the risk of heart defects following first-trimester exposure to methylphenidate but not to amphetamines” (from ScienceDaily)

 

9 – The Surprising Effects of Loneliness on Health – The New York Times (10 articles per month are free)

 

10 – Individualized Glycemic Control for U.S. Adults With Type 2 Diabetes: A Cost-Effectiveness Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Individualized Glycemic Control Could Safely Cut Costs in Type 2 Diabetes – Physician’s First Watch (free) AND Individualized HbA1c Targets for Diabetes Drop Cost, Improve QoL – Medscape (free registration required) AND Personalized Blood Sugar Goals Can Save Diabetes Patients Thousands – University of Chicago Medical Center, via NewsWise (free)

 


 

1 – The BMJ Christmas Issue – “The soul of the Christmas issue is originality. We don’t want to publish anything that resembles anything we’ve published before” (see details).

 

Original Article 1: Does Peppa Pig encourage inappropriate use of primary care resources? (free) AND Commentary: Peppa Pig might inspire unrealistic expectations of GPs – OnMedica (free)

Original Article 2 The science behind “man flu” (free) AND Commentary: Of mice and “man flu” – HealthNewsReview (free)

See also: The top six BMJ Christmas papers – Medical News Today (free) AND The BMJ Holiday Issue: Rain Doesn’t Mean More Joint Pain; Wine Glasses Getting Bigger – Physician’s First Watch (free)

 

2 – The Less-Is-More Crusade — Are We Overmedicalizing or Oversimplifying? – New England Journal of Medicine (free)

 

3 – Noninvasive Cardiac Radiation for Ablation of Ventricular Tachycardia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: A ‘Game Changer’ for Patients With Irregular Heart Rhythm – The New York Times (10 articles per month are free)

“The use of stereotactic radiotherapy in five patients with refractory ventricular tachycardia (VT) showed a 99.9% reduction in VT burden”. (via @NEJM see Tweet with infographic)

 

4 – The American Society of Colon and Rectal Surgeons Clinical Practice Guideline for the Prevention of Venous Thromboembolic Disease in Colorectal Surgery – Diseases of The Colon & Rectum (free)

 

5 – AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free) (via @kennylinafp see Tweet)

Commentary: New Hypertension Guideline: A Case of Guideline Creep? – Medscape (free registration required)

 

6 – Artificial Intelligence Promising for CA, Retinopathy Diagnoses – Physician’s Weekly (free)

Original Article 1: Diagnostic Assessment of Deep Learning Algorithms for Detection of Lymph Node Metastases in Women With Breast Cancer – JAMA (link to abstract – $ for full-text) AND Commentary: Findings Show Potential Use of Artificial Intelligence in Detecting Spread of Breast Cancer – The JAMA Network (free)

Original Article 2: Development and Validation of a Deep Learning System for Diabetic Retinopathy and Related Eye Diseases Using Retinal Images From Multiethnic Populations With Diabetes – JAMA (link to abstract – $ for full-text) AND Commentary: Artificial Intelligence Detects Diabetic Retinopathy and Related Eye Diseases among Patients with Diabetes – The JAMA Network (free)

 

7 – People Don’t Take Their Pills. Only One Thing Seems to Help. – The New York Times (10 articles per month are free)

“High-tech approaches and “reminder” packaging don’t work well. Reducing prices does”.

 

8 – Supplement: The Economics of Hypertension and Cardiovascular Disease – American Journal of Preventive Medicine (free editorials, reviews and research articles)

Source: EvidenceAlerts

 

9 – Phone Addiction Is Real — And So Are Its Mental Health Risks – Forbes (free)

Related commentaries: We Need to Talk About Kids and Smartphones – TIME (free) AND Have Smartphones Destroyed a Generation? – The Atlantic (free) How Smartphones Hijack Our Minds – The Wall Street Journal (a few articles per month are free)

 

10 – Atraumatic versus conventional lumbar puncture needles: a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentaries: Atraumatic needles associated with fewer side effects for lumbar puncture – ACP Hospitalist Weekly (free) AND Atraumatic Lumbar Puncture Needles Show Major Benefit in Meta-Analysis – Physician’s First Watch (free)

 


 

1 – The Altmetric TOP 100 Articles. What academic research caught the public imagination in 2017? (free)

 

2 – Universal Health Coverage Day, 12 December 2017 – World Health Organization (free resources)

Fact Sheet: Universal Health Coverage (UHC) – World Health Organization (free)

Related: Opinion: 5 ways to make progress towards universal health coverage – Devex (free)

 

3 – Hormone Therapy for the Primary Prevention of Chronic Conditions in Postmenopausal Women: US Preventive Services Task Force Recommendation Statement – JAMA (free)

JAMA Editorials: Menopausal Hormone Therapy for Primary Prevention of Chronic Disease (free) AND Evidence for Postmenopausal Hormone Therapy to Prevent Chronic Conditions: Success, Failure, and Lessons Learned (free) AND Menopausal Hormone Therapy for the Primary Prevention of Chronic Conditions: Unfulfilled Expectations (free)

Audio Interview: USPSTF Recommendation Statement: Hormone Therapy After Menopause (free)

Summary: Hormone Therapy Not Recommended for Prevention of Chronic Conditions in Postmenopausal Women – The JAMA Network (free)

“The U.S. Preventive Services Task Force (USPSTF) recommends against the use of combined estrogen and progestin in postmenopausal women, or estrogen alone in postmenopausal women who have had a hysterectomy, to prevent chronic conditions such as heart disease, dementia and stroke”.

 

4 – CAR T-Cell Therapies Drive Outcomes in Lymphoma, Myeloma: Treatments Hold Promise for People with Hard-to-Treat Blood Cancers – 2017 American Society of Hematology Annual Meeting (free)

Related commentary: CAR T-Cell Therapy Makes Further Inroads in Lymphoma and Myeloma – ASCO Post (free)

Related Study: Chimeric Antigen Receptor T Cells in Refractory B-Cell Lymphomas – New England Journal of Medicine (free), Editorial: A Milestone for CAR T Cells (free) AND Visual Abstract (free)

 

5 – Topical Tranexamic Acid Compared With Anterior Nasal Packing for Treatment of Epistaxis in Patients Taking Antiplatelet Drugs: Randomized Controlled Trial – Academic Emergency Medicine (link to abstract – $ for full-text)

Commentary: Topical TXA in Epistaxis – R.E.B.E.L.em (free)

 

6 – Get Ready For A Tsunami Of ECGs – Cardiobrief (free)

Related: Thoughts on the Apple Watch and Mobile ECG, by Dr John Mandrola (free) AND Overdiagnosis Only a Matter of Time With ECG Watches – Medscape (free registration required)

 

7 – State of The Art Review: Recent advances in pre-exposure prophylaxis for HIV – The BMJ (free fo 2 weeks)

Related Guidelines: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection – World Health Organization (free) AND Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free PDF)

Related Commentary: Why PrEP takers should still use condoms with HIV+ partners – The Conversation (free)

 

8 – All-cause mortality and major cardiovascular outcomes comparing percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: a meta-analysis of short-term and long-term randomised trials – OpenHeart (free)

“PCI is associated with a reduction in the risk of major cardiovascular outcomes at short-term follow-up in patients with LMCA stenosis; but at long term, MACCE rate is increased for PCI”

 

9 – Pediatric Injuries Related to Window Blinds, Shades, and Cords – Pediatrics (free)

Commentaries: Researchers: Window Blind Cords as Dangerous to Young Children as Bodies of Water – Physician’s First Watch (free) AND Kids continue to die in window-blind accidents, despite safety warnings – Reuters (free)

 

10 – Severe COPD and the transition to a palliative approach – Breathe (free)

See more on palliative care in chronic respiratory disorders in our Decembe 6th issue (see #10)

 


 

1 – The other big drug problem: Older people taking too many pills – The Washington Post (free)

Related Articles and Commentaries: Current and future perspectives on the management of polypharmacy – BMC Family Medicine (free) 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND Common ED Medication Errors: Polypharmacy – emDocs (free)

Related Website and Guidelines: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free)

 

2 – Treated Incidence of Psychotic Disorders in the Multinational EU-GEI Study – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Environment May Play Major Role in Psychosis – PsychCentral (free) AND Psychosis incidence highly variable internationally – University College London, via EurekAlert (free)

 

3 – Mortality Associated with Metformin Versus Sulfonylurea Initiation: A Cohort Study of Veterans with Diabetes and Chronic Kidney Disease – Journal of General Internal Medicine (link to abstract – $ for full-text)

Commentaries: Metformin appears better than sulfonylureas as first-line therapy for patients with CKD – ACP Diabetes (free) AND Metformin May Up Survival in Older Men With Moderate CKD – Medscape (free registration required)

 

4 – Diet quality is associated with disability and symptom severity in multiple sclerosis – Neurology (link to abstract – $ for full-text)

Commentaries: Healthy diet may be linked to less disability, fewer symptoms for people with MS – News Medical (free) AND High-quality Diet, Healthy Lifestyle May Reduce MS Disability – Medscape (free registration required) AND Healthy Diet Tied to Less MS Disability – MedPage Today (free registration required)

 

5 – Review: Lung Manifestations in the Rheumatic Diseases – Chest (free)

Source: Critical Care Reviews Newsletter

 

6 – Review: Diagnosis and treatment of hyperkalemia – Cleveland Clinic Journal of Medicine (free)

Source: Critical Care Reviews Newsletter

 

7 – Viewpoint: Disclosures in Nutrition Research: Why It Is Different – JAMA (free)

“Medical researchers must disclose financial conflicts of interest. An article in @JAMA_current says nutrition researchers should also be obliged to disclose their food-related religious beliefs, comments to the public and personal diet”. (via @davidludwigmd see Tweet)

 

Expert consensus document: Advances in the physiological assessment and diagnosis of GERD – Nature Reviews Gastroenterology & Hepatology (free)

Commentary: Expert Consensus on the Assessment and Diagnosis of GERD – PracticeUpdate (free registration required)

 

9 – Intrauterine insemination with ovarian stimulation versus expectant management for unexplained infertility (TUI): a pragmatic, open-label, randomised, controlled, two-centre trial – The Lancet (link to abstract – $ for full-text)

Commentary: Fertility study shows cheaper treatment is effective – MedicalXpress (free)

 

10 – Caesarean section is better for extremely premature breech babies but not necessarily for their mothers – NIHR Signal (free)

“Delivering extremely preterm breech babies (23 to 27 weeks) by caesarean reduced the risk of infant death or brain bleeds by around 40%, compared with vaginal delivery”. (RT @NIHR_DC see Tweet)

 


 

1 – ADA 2018 Standards of Medical Care in Diabetes – Diabetes Care (Free Supplement)

News Release: American Diabetes Association Releases 2018 Standards of Medical Care in Diabetes, with Notable New Recommendations for People with Cardiovascular Disease and Diabetes (free)

Summary of Revisions: Standards of Medical Care in Diabetes—2018 (free)

Commentaries: ADA 2018 Standards Address Diabetes Drugs With CV Benefit – Medscape (free registration required)

 

2 – Standards of Medical Care in Diabetes—2018 Abridged for Primary Care Providers – Diabetes Care (free PDF)

Commentary: ADA 2018 Abridged Standards of Medical Care in Diabetes: Update for Primary Care – Medscape (free registration required

 

3 – Pharmacomechanical Catheter-Directed Thrombolysis for Deep-Vein Thrombosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Pharmacomechanical Thrombolysis for Deep-Vein Thrombosis – NEJM Resident 360 (free) AND Pharmacomechanical Thrombolysis for DVT – American College of Cardiology, Latest in Cardiology (free)

Pharmacomechanical thrombolysis did not result in lower risk of post-thrombotic syndrome and was associated with higher risk of major bleeding.

 

4 – Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials – Intensive Care Medicine (free)

PPIs are the most effective agents in preventing CIB, but they may increase the risk of pneumonia”.

 

5 – Seven-Year Weight Trajectories and Health Outcomes in the Longitudinal Assessment of Bariatric Surgery (LABS) Study – JAMA Surgery (free)

Commentaries: We’re barely using the best tool we have to fight obesity – VOX (free) AND Gastric bypass patients sustain long-term weight loss, comorbidity reduction – Cardiovascular Business (free) AND Weight Loss After Bariatric Procedures Mostly Sustained Over Time – Medical Research (free)

 

6 – Bedtime Use of Technology and Associated Sleep Problems in Children – Global Pediatric Health (free)

Commentary: Screen time before bed linked with less sleep, higher BMIs in kids – Penn State, via ScienceDaily (free)

 

7 – Opinion: Does Cancer Screening Save More Lives Overall? Not Necessarily – WBUR (free) (via @HealthNewsRevu see Tweet)

Related systematic review: Does screening for disease save lives in asymptomatic adults? Systematic review of meta-analyses and randomized trials – International Journal of Epidemiology (free)

“We are not suggesting that cancer screening is useless. Our critique aims to show that screening tests are like any other medical intervention: there are benefits and harms.  And it’s why we support informed decision-making”.

 

8 – Themed Review: Comprehensive Care: Older People Living With Frailty in Hospitals  – NIHR Dissemination Centre (free download)

 

9 – Non-invasive cardiovascular imaging for evaluating subclinical target organ damage in hypertensive patients: A consensus paper from the European Association of Cardiovascular Imaging (EACVI), the European Society of Cardiology Council on Hypertension, and the European Society of Hypertension (ESH) – European Heart Journal Cardiovascular Imaging (free)

 

10 – The best and worst analogies for CRISPR, ranked – STAT (free)

Related: Simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free)

 


 

1 – First Dementia Global Monitoring System Launched: Global Dementia Observatory (free resources)

News release: Dementia: number of people affected to triple in next 30 years – World Health Organization (free)

 

2 – The global burden of tuberculosis: results from the Global Burden of Disease Study 2015 – The Lancet Infectious Diseases (free)

Invited Commentary: Tuberculosis eradication: renewed commitment and global investment required (free)

 

3 – Practical Recommendations of the Obesity Management Task Force of the European Association for the Study of Obesity for the Post-Bariatric Surgery Medical Management (free)

 

4 – Systematic review of dietary trans-fat reduction interventions – Bulletin of The World Health Organization (free)

Related: Banning trans fats in New York prevented thousands of heart attacks, study finds – STAT News (free) AND The Worst Fat in the Food Supply – The New York Times (10 articles per month are free)

 

5 – Perioperative Myocardial Injury After Noncardiac Surgery: Incidence, Mortality, and Characterization – Circulation (free PDF)

Commentaries: Myocardial Injury After Noncardiac Surgery Linked With Higher 1-Year Mortality – TCTMD (free) AND Perioperative Myocardial Injury After Noncardiac Surgery – American College of Cardiology, Latest in Cardiology (free)

 

6 – Analysis: Transvaginal mesh failure: lessons for regulation of implantable devices – The BMJ (free)

Related commentaries: Women harmed because vaginal mesh regulation ‘not fit for purpose’ – The Guardian (free) AND Vaginal mesh operations for prolapse should be banned, watchdog to say – The Guardian (free)

 

7 – Case-control and Cohort studies: A brief overview – Students 4 Best Evidence (free)

 

8 – Blood Pressure Trajectories in the 20 Years Before Death – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Blood pressure declines 14 to 18 years before death – University of Connecticut, via ScienceDaily (free) AND Long, Slow Decline in BP Often Precedes Seniors’ Death – MedPage Today (free registration required)

 

9 – Understanding common misconceptions about p-values – The 20% Statistician (free)

Related review: Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations – European Journal of Epidemiology (free)

Source: Nature Briefing Newsletter

 

10 – Low FODMAP diet may improve irritable bowel symptoms more than other diets – NIHR Signal (free)

Original article: Low fermentable oligosaccharides, disaccharides, monosaccharides and polyols (FODMAP) diet improves symptoms in adults suffering from irritable bowel syndrome (IBS) compared to standard IBS diet: A meta-analysis of clinical studies – PLOS One (free)

 

 


 

1 – Book: Child and Adolescent Health and Development – Disease Control Priorities, 3rd Edition (free)

Press Release: DCP3 Publishes Latest Volume: Child and Adolescent Health and Development (free)

Key Messages from the Series: Disease Control Priorities 3rd edition – The Lancet (7 reviews – free registration required)

Other books in the series: Essential Surgery / Reproductive, Maternal, Newborn, and Child Health / Cancer / Mental, Neurological, and Substance Use Disorders / Injury Prevention and Environmental Health / Major Infectious DiseasesCardiovascular, respiratory, and related disorders / Disease Control Priorities (all free)

“Third edition of Disease Control Priorities launches today. A vast resource evaluating policy choices affecting the access, uptake & quality of interventions & delivery platforms to improve health in LMICs”. (RT @MRCTEG_LSHTM see Tweet)

 

2 – Contemporary Hormonal Contraception and the Risk of Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Even Low-Dose Contraceptives Slightly Increase Breast Cancer Risk – NPR (free) AND Study confirms higher breast cancer risk with hormone-based contraception – Reuters (free) AND Small risk of breast cancer seen with hormone contraceptives – Associated Press (free) All forms of hormonal contraception carry breast cancer risk, study finds – the Guardian (free) AND Birth Control Pills Still Linked to Breast Cancer, Study Finds – The New York Times (10 articles per month are free)

 

3 – Effectiveness of and overdiagnosis from mammography screening in the Netherlands: population based study – The BMJ (free)

Editorial: Breast cancer screening (free)

Commentaries: Breast cancer screening has ‘little impact’ on cancer deaths – OnMedica AND It’s Time to End Mammograms, Some Experts Say – TIME (free)

See more on the arguments for and against screening for breast cancer with mammography in our November 7th issue (see #4)

 

4 – Hemophilia B Gene Therapy with a High-Specific-Activity Factor IX Variant – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Gene Therapy for Factor IX Deficiency (free)

Commentary: One-dose gene therapy produces clotting factor, safely stops bleeding in hemophilia B patients – MedicalXpress (free)

 

5 – Recovery after critical illness: putting the puzzle together—a consensus of 29 – Critical Care (free)

 

6 – Moral Choices for Today’s Physician – JAMA (free)

 

7 – Two nerve drugs are not suitable for treating long-term low back pain – NIHR Signal (free)

Original Article: Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials – PLOS One (free)

“Evidence supports NICE guidance not to use two nerve drugs (gabapentin and pregabalin) to treat long-term lower back pain”. (RT @NIHR_DC see Tweet)

 

8 – Oral Sex and Condom Use in a U.S. National Sample of Adolescents and Young Adults – Journal of Adolescent Health (link to abstract – $ for full-text)

Commentary: Kids aren’t protecting themselves against STDs during oral sex – Reuters (free)

 

9 – Respiratory and cardiovascular responses to walking down a traffic-polluted road compared with walking in a traffic-free area in participants aged 60 years and older with chronic lung or heart disease and age-matched healthy controls: a randomised, crossover study – The Lancet (free)

Commentaries: Walking to a pathway for cardiovascular effects of air pollution – The Lancet (free) AND Traffic fumes in city streets ‘largely wipe out exercise benefits for over-60s’ – The Guardian (free)

 

10 – Impact of London’s road traffic air and noise pollution on birth weight: retrospective population based cohort study – The BMJ (free)

Editorial: Traffic pollution is linked to poor pregnancy outcomes (free)

Commentary: Air pollution from London traffic is affecting the health of unborn babies – Imperial College London (free) AND Traffic pollution linked to low birth weight of unborn babies, study reveals – Medical News (free)

 


 

1 – Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Intensive weight loss can ‘reverse’ type 2 diabetes – OnMedica (free) AND Weight Management May Reverse T2D – MedPage Today (free registration required) AND Radical diet can reverse type 2 diabetes, new study shows – The Guardian (free)

 

2 – Modern contraceptive use, unmet need, and demand satisfied among women of reproductive age who are married or in a union in the focus countries of the Family Planning 2020 initiative: a systematic analysis using the Family Planning Estimation Tool – The Lancet (free)

Related Report: FP2020 – The Way Ahead (free)

Commentaries: Contraceptive use gaining momentum in world’s poorest countries – Reuters (free) AND FP2020 reports progress on family planning, but faces an uphill battle – Devex (free)

 

3 – Validation and diagnostic accuracy of predictive curves for age-associated longitudinal cognitive decline in older adults – Canadian Medical Association Journal (free)

Commentaries: New easy-to-use tool can help determine Alzheimer’s risk, similar to pediatric growth curves – CMAJ, via EurekAlert (free) AND Cognitive Decline Charts Could Help Flag Whether Patient Has Dementia – Physician’s First Watch (free)

 

4 – Readmissions After Revascularization Procedures for Peripheral Arterial Disease: A Nationwide Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Burden of Readmission High in PAD Patients Following Revascularization – TCTMD (free) AND 1 in 6 Patients Undergoing Peripheral Arterial Revascularization Readmitted Within 30 Days – Physician’s First Watch (free) AND 1 in 6 Readmitted After Peripheral Revascularization – MedPage Today (free registration required)

 

5 – It’s Gonna Get a Lot Easier to Break Science Journal Paywalls – Wired (Free) (via @EricTopol)

 

6 – Cherry-picking by trialists and meta-analysts can drive conclusions about intervention efficacy – Journal of Clinical Epidemiology (free)

 

7 – A Failure to Heal – The New York Times Magazine (10 articles per month are free) (RT @camialderighi see Tweet)

 

8 – Association of Clinician Denial of Patient Requests With Patient Satisfaction – JAMA Internal Medicine (free)

Commentaries: Clinician denial of certain patient requests linked with decreased satisfaction – 2 Minute Medicine (free) AND Denial of some patient requests, but not others, associated with decreased patient satisfaction, study finds – ACP Internist (free) AND Patient satisfaction surveys are worthless – Physician’s Weekly (free)

 

9 – Association of US State Implementation of Newborn Screening Policies for Critical Congenital Heart Disease With Early Infant Cardiac Deaths – JAMA (free)

Commentaries: Newborn Screening Policies For CHD Associated With Lower Infant Deaths – American College of Cardiology, Latest in Cardiology (free) AND Infant CCHD deaths cut by 33% after mandatory pulse oximetry testing – Cardiovascular Business (free) AND Screening for Critical Congenital Heart Disease at Birth Saves Lives – CDC (free)

Related guideline: Canadian Cardiovascular Society/Canadian Pediatric Cardiology Association Position Statement on Pulse Oximetry Screening in Newborns to Enhance Detection of Critical Congenital Heart Disease (free)

 

10 – Advance care planning for patients with chronic respiratory diseases: a systematic review of preferences and practices – Thorax (link to abstract – $ for full-text)

Commentary: Doctors rarely discuss end-of-life care for chronic lung conditions – Reuters (free)

Related guideline: An Official American Thoracic Society Clinical Policy Statement: Palliative Care for Patients with Respiratory Diseases and Critical Illnesses (free)

 


 

1 – Association of Overlapping Surgery With Increased Risk for Complications Following Hip Surgery: A Population-Based, Matched Cohort Study – JAMA Internal Medicine (free)

Editorial: Overlapping Surgery – Perspectives From the Other Side of the Table (free)

Commentaries: Study: Overlapping surgeries boost complication risks – Becker’s Hospital Review (free) AND Does Overlapping Surgery Increase Complication Risk After Hip Surgery? – The JAMA Network (free)

 

2 – Cheese consumption and risk of cardiovascular disease: a meta-analysis of prospective studies – European Journal of Nutrition (link to abstract – $ for full-text)

Commentary: Eating 40g of cheese a day may reduce heart attack and stroke risk – NHS Choices (free)

Related meta-analysis: Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies – European Journal of Epidemiology (free)

 

3 – WHO reviewing data on Sanofi dengue vaccine, urges limited use – Reuters (free)

Related: Brazil recommends restrictions on Sanofi dengue vaccine – Reuters (free) AND Sanofi restricts dengue vaccine but downplays antibody enhancement – CIDRAP (free) AND New dengue vaccine could worsen disease in some people – STAT (free)

 

4 – 2017 Update in perioperative medicine: 6 questions answered – Cleveland Clinic Journal of Medicine (free)

 

5 – Pulmonary embolus in the ED – Which patients require systemic thrombolytics? – emDocs (free)

 

6 – An Unconscious Patient with a DNR Tattoo – New England Journal of Medicine (free)

Commentary: His tattoo said “do not resuscitate.” Doctors wanted another opinion – The New York Times (free)

 

7 – Headline vs. study: The unbearable heaviness of false hope – HealthNews Review (free)

 

8 – Our Review Criteria – HealthNewsReview (free)

“Such a great list! Ten Criteria for Reviewing a News Article on Health. Cost, harms, quality of evidence, disease-mongering, conflict of interest, etc.” (RT @CaulfieldTim see Tweet)

 

9 – Richard Lehman’s journal review, 4 December 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

10 – Cognitive trajectories from infancy to early adulthood following birth before 26 weeks of gestation: a prospective, population-based cohort study – Archives of Disease in Childhood (free)

Commentary: Does Cognition in Children Born Extremely Preterm Catch Up by Early Adulthood? – Journal Watch (free)

 


 

1 – SIGN Guidelines on Pharmacological management of glycaemic control in people with type 2 diabetes & Management of diabetes – Scottish Intercollegiate Guidelines Network (free guidelines and resources) (via @kamleshkhunti)

 

2 – HIV Prevention Efforts and Incidence of HIV in Uganda – New England Journal of Medicine (free)

Commentaries: Combination HIV prevention reduces new infections by 42 percent in Ugandan district – National Institutes of Health (free) AND Combination HIV Prevention Reduces Infections – MD Magazine (free)

 

3 – 2017 ACC Expert Consensus Decision Pathway on Management of Bleeding in Patients on Oral Anticoagulants – Journal of The American College of Cardiology (free)

Commentary and Summary: Consensus for Management of Bleeding on Oral Anticoagulants – American College of Cardiology, Latest in Cardiology (free)

 

4 – Clinical Guidelines Synopsis: Diagnostic Testing for Obstructive Sleep Apnea in Adults – JAMA (free)

 

5 – Vitamin D supplementation during pregnancy: state of the evidence from a systematic review of randomised trials – The BMJ (free)

Commentaries: Evidence Insufficient to Recommend Prenatal Vitamin D Supplementation, Researchers Say – Physician’s First Watch (free) AND Jury Still Out on Vitamin D Supplements in Pregnancy – MedPage Today (free registration required)

 

6 – Risk of death associated with new benzodiazepine use among persons with Alzheimer disease: A matched cohort study – International Journal of Geriatric Psychiatry (link to abstract – $ for full-text) (RT @Deprescribing see Tweet)

Commentaries: Benzodiazepines linked to increased risk of death among Alzheimer’s disease patients – News Medical (free) AND Benzodiazepines Tied to a 41% Increased Mortality Risk in AD – Medscape (free registration required)

 

7 – Rational decision making in medicine: Implications for overuse and underuse – Journal of Evaluation in Clinical Practice (free) (via @AllenFrancesMD)

 

8 – Cardiovascular and type 2 diabetes morbidity and all-cause mortality among diverse chronic inflammatory disorders – Heart (free)

 

9 – Disparities in the Quality of Cardiovascular Care Between HIV‐Infected Versus HIV‐Uninfected Adults in the United States: A Cross‐Sectional Study – Journal of The American Heart Association (free)

Commentaries: HIV-positive adults are under-treated for cardiovascular problems compared to those without HIV – UCLA Research Alert (free) AND HIV patients less likely to be prescribed aspirin, statins despite increased cardiovascular risk – Cardiovascular Research (free)

Related: Cardiovascular risk and dyslipidemia among persons living with HIV: a review – BMC Infectious Diseases (free)

 

10 – European Thyroid Association Guidelines for Ultrasound Malignancy Risk Stratification of Thyroid Nodules in Adults: The EU-TIRADS – European Tyroid Journal (free)

Related guideline: ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee – Journal of the American College of Radiology (free PDF)

 


 

1 – World AIDS Day, 1 December 2017 – World Health Organization (free)

 

2 – Book: Cardiovascular, respiratory, and related disorders – Disease Control Priorities, 3rd Edition (free)

Press Release: Disease Control Priorities, 3rd Edition Launches Volume on Cardiovascular, Respiratory, and Related Disorders (free)

Summary: Cardiovascular, respiratory, and related disorders: key messages from Disease Control Priorities, 3rd edition – The Lancet (free registration required)

Previous volumes: 1 – Essential Surgery / 2 – Reproductive, Maternal, Newborn, and Child Health / 3 – Cancer / 4 – Mental, Neurological, and Substance Use Disorders / 5 – Injury Prevention and Environmental Health / 6 – Major Infectious Diseases (all free)

 

3 – Guideline: Protecting, promoting and supporting breastfeeding in facilities providing maternity and newborn services – World Health Organization (free)

 

4 – Guideline: Outbreak Response and Incident Management: SHEA Guidance and Resources for Healthcare Epidemiologists in United States Acute-Care Hospitals – Infection Control and Hospital Epidemiology (free)

Commentary: New document guides hospitals in responding to infectious disease outbreaks – Society for Healthcare Epidemiology of America (free)

 

5 – Marriage and risk of dementia: systematic review and meta-analysis of observational studies – Journal of Neurology Neurosurgery and Psychiatry (free)

Commentaries: Single people have a higher risk of dementia – OnMedica (free) AND Marriage linked to lower dementia risk – Reuters (free)

 

6 – Worldwide burden of cancer attributable to diabetes and high body-mass index: a comparative risk assessment – The Lancet Diabetes & Endocrinology (free)

Editorial: Diabetes and adiposity: a heavy load for cancer (free)

Commentaries: Diabetes and obesity together responsible for nearly 800,000 cancers worldwide – Imperial College London (free) AND ‘Alarming’ rise in cancer rates driven by diabetes, obesity – Medical News Today (free) AND Nearly 6% of cancers worldwide are attributable to diabetes and obesity – eCancer News (free)

 

7 – Conventional Polysomnography Is Not Necessary for the Management of Most Patients with Suspected Obstructive Sleep Apnea. Noninferiority, Randomized Controlled Trial – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Conventional Polysomnography vs. Home Testing for Obstructive Sleep Apnea – Journal Watch (free) AND Home Sleep Testing OK for Evaluating Suspected Sleep Apnea – MedPage Today (free registration required)

Related: Clinical Practice Guideline for Diagnostic Testing for Adult Obstructive Sleep Apnea: An American Academy of Sleep Medicine Clinical Practice Guideline (free)

 

8 – Unnecessary Tests and Treatment Explain Why Health Care Costs So Much – Scientific American (free)

 

9 – Big data often yields small returns. Here’s how to fix that – STAT (free)

 

10 – Diagnostic Accuracy of Pediatric Teledermatology Using Parent-Submitted Photographs: A Randomized Clinical Trial – JAMA Dermatology (link to abstract – $ for full-text)

Commentaries: Parent-Supplied Photos Allow Pediatric Dermatology Diagnoses without an Office Visit in Most Instances – Children’s Hospital of Philadelphia (free) AND Smartphone pics may be sharp enough for dermatology diagnosis – Reuters (free)

 


 

1 – Guideline: Asthma: diagnosis, monitoring and chronic asthma management – National Institute for Health and Care Excellence (free)

News release: New ways to diagnose and manage asthma can improve care, says NICE (free)

Commentaries: NICE changes guidelines on asthma – PharmaTimes (free) AND NICE releases the latest asthma management standards – News Medical (free)

 

2 – The potential impact of food taxes and subsidies on cardiovascular disease and diabetes burden and disparities in the United States – BMC Medicine (free) (via @ArsenaultBenoit)

Related Guideline: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free)

Related articles: Reducing US cardiovascular disease burden and disparities through national and targeted dietary policies: A modelling study – PLOS Medicine (free) AND Taxes and Subsidies for Improving Diet and Population Health in Australia: A Cost-Effectiveness Modelling Study – PLOS Medicine (free) AND Policy lessons from health taxes: a systematic review of empirical studies – BMC Public Health (free)

 

3 – Association Between Wait Time and 30-Day Mortality in Adults Undergoing Hip Fracture Surgery – JAMA (link to abstract – $ for full-text)

Commentaries: Delaying Surgery for Hip Fracture for More Than One Day Associated with Small Increased Risk of Death – The JAMA Network (free) AND Delaying Hip Fracture Surgery for 1 Day Tied to Higher Mortality Risk – Physician’s First Watch (free) AND Emergency Hip Surgery Best Done Within 24 Hours – Medscape (free registration required)

 

4 – Gene Therapy Shows Promise For A Growing List Of Diseases – NPR (free)

 

5 – A three-talk model for shared decision making: multistage consultation process – The BMJ (free)

 

6 – Treatment eligibility and retention in clinical HIV care: A regression discontinuity study in South Africa – PLOS Medicine (free)

Commentary: Immediate ART treatment improves retention rates – Boston University School of Medicine (free)

 

7 – Platelet Transfusion for Patients With Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

8 – European Society of Cardiology: Cardiovascular Disease Statistics 2017 – European Journal of Cardiology (free)

“The European Atlas of Cardiology brings together data from 56 countries to demonstrate the prevalence and cost of cardiovascular disease, and the need to utilise resources more effectively” (RT @OUPMedicine see Tweet)

 

9 – Computerised decision support can improve antibiotic prescribing in hospitals – NIHR Signal (free)

Original Article: The effectiveness of computerised decision support on antibiotic use in hospitals: A systematic review – PLOS One (free)

 

10 – Palliative Care Eligibility, Symptom Burden, and Quality-of-Life Ratings in Nursing Home Residents – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Nursing home residents eligible for palliative care often don’t get it – Reuters (free) AND Most nursing home residents eligible for palliative care but lack access – MedicalXpress (free)

 


 

1 – World Malaria Report 2017 – World Health Organization (free)

News release: Global response to malaria at crossroads (free)

“After unprecedented global success in malaria control, progress has stalled”

 

2 – Effect of Oral Capsule– vs Colonoscopy-Delivered Fecal Microbiota Transplantation on Recurrent Clostridium difficile Infection: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Comparison of Fecal Transplant Using Capsule vs Colonoscopy to Prevent Clostridium Difficile Infection – The JAMA Network (free) AND New evidence suggests there’s a much easier way to get a fecal transplant – Quartz (free) AND Fecal transplant by capsule may match colonoscopy for C diff – CIDRAP (free)

Related: Faecal transplant effectively treats recurrent or unresponsive Clostridium difficile – NIHR Signal (free)

 

3 – Oral anticoagulants for prevention of stroke in atrial fibrillation: systematic review, network meta-analysis, and cost effectiveness analysis – The BMJ (free)

Commentary: Comparison of Oral Anticoagulants for Preventing Stroke in AF – MPR (free)

 

4 – The Value-Based Payment Modifier: Program Outcomes and Implications for Disparities – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Pay-for-performance fails to perform – Harvard Medical School, via ScienceDaily (free)

Related: The Effects of Pay-for-Performance Programs on Health, Health Care Use, and Processes of Care: A Systematic Review – Annals of Internal Medicine (free) AND Value-Based Purchasing: Time for Reboot or Time to Move On? by Ashish K. Jha, MD – The JAMA Forum (free)

 

5 – Tens of thousands dying from $30 billion fake drugs trade, WHO says – Reuters Health (free)

Related: About 11 percent of drugs in poor countries are fake, U.N. says – Associated Press (free)

 

6 – Five ways to fix statistics – Nature (free)

“As debate rumbles on about how and how much poor statistics is to blame for poor reproducibility, Nature asked influential statisticians to recommend one change to improve science. The common theme? The problem is not our maths, but ourselves”.

 

7 – Richard Lehman’s journal review, 27 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Indications and practical approach to non-invasive ventilation in acute heart failure – European Heart Journal (free)

 

9 – Long-term effects of glucocorticoids on function, quality of life, and survival in patients with Duchenne muscular dystrophy: a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Glucocorticoids offer long-term benefits for patients with Duchenne muscular dystrophy – Children’s National Health System, via ScienceDaily (free)

 

10 – Aerobic exercise moderately reduces depressive symptoms in new mothers – NIHR Signal (free)

Original article: Does aerobic exercise reduce postpartum depressive symptoms? a systematic review and meta-analysis – British Journal of General Practice (free)

“Involving new mothers in group exercise programmes, or advising them on an exercise of their choice, reduced depressive symptoms compared with usual care” (RT @NIHR_DC see Tweet)

 


 

1 – Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free)

Commentaries: New HIV guideline outlines cost-effective prevention strategies for high-risk people – ScienceDaily (free)

Related Free Online Course (Starts Dec 04): PrEParing: PrEP for Providers and Patients – Johns Hopkins University and Coursera

Related guidance: WHO implementation tool for pre-exposure prophylaxis of HIV infection (free) AND Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free)

 

2 – Pharmacologic Treatment of Seasonal Allergic Rhinitis: Synopsis of Guidance From the 2017 Joint Task Force on Practice Parameters – Annals of Internal Medicine (free)

 

3 – 2017 Roadmap for Innovation—ACC Health Policy Statement on Healthcare Transformation in the Era of Digital Health, Big Data, and Precision Health – Journal of The American College of Cardiology (free)

News Release: ACC’s Innovation Roadmap Provides Framework for Future of Care Delivery (free)

Summary with key points to remember: ACC Statement on Transforming Cardiovascular Care Through Innovation (free)

 

4 – Prevalence of Prior Cancer Among Persons Newly Diagnosed With Cancer: An Initial Report From the Surveillance, Epidemiology, and End Results Program – JAMA Oncology (free)

Commentary: How Common Are New Cancers in Cancer Survivors? – The JAMA Network (free) AND New cancers common in cancer survivors – OnMedica (free)

 

5 – The Motivational Impact of Wearable Healthy Lifestyle Technologies: A Self-determination Perspective on Fitbits With Adolescents – American Journal of Health Education (free)

Commentaries: Young people oppose Fitbits in schools – The Conversation (free) AND Activity Trackers Don’t Always Work the Way We Want Them To – The New York Times (10 articles per month are free) AND Fashionable FitBits discourage young teens from exercising, study finds – MedicalXpress (free)

 

6 – Sinusitis Mimics: ED-relevant pearls and pitfalls – emDocs (free)

 

7 – Adherence to a Healthy Lifestyle is Associated With a Lower Risk of Diverticulitis among Men – American Journal of Gastroenterology (link to abstract – $ for full-text)

Commentary: Unhealthy lifestyle may cause half of diverticulitis cases – Reuters (free)

 

8 – Does contrast cause kidney injury? The evidence – First10EM (free)

 

9 – SACN-COT statements on potassium-based sodium replacers – Public Health England (free)

Commentary: Experts urge use of salt alternative in food products – The Guardian (free)

 

10 – Faecal transplant effectively treats recurrent or unresponsive Clostridium difficile – NIHR Signal (free)

Original article: Systematic review with meta-analysis: the efficacy of faecal microbiota transplantation for the treatment of recurrent and refractory Clostridium difficile infection – Alimentary Pharmacology and Therapeutics (link to abstract – $ for full-text)

 


 

1 – Management of tricuspid valve regurgitation: Position statement of the European Society of Cardiology Working Groups of Cardiovascular Surgery and Valvular Heart Disease – European Journal of Cardio-Thoracic Surgery (free) (via @rafavidalperez)

 

2 – A Test-and-Not-Treat Strategy for Onchocerciasis in Loa loa–Endemic Areas – New England Journal of Medicine (free)

Editorial: Mass Administration of Ivermectin in Areas Where Loa loa Is Endemic (free)

Quick Take Video Summary: Point-of-Care Loa loa Testing for Onchocerciasis Control (free)

 

3 – Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU) – The BMJ (free)

“Low dose aspirin does not increase time to healing of venous leg ulcers, percentage healed, estimated change in venous leg ulcer area, or change in health related quality of life”.

 

4 – AVATAR therapy for auditory verbal hallucinations in people with psychosis: a single-blind, randomised controlled trial – The Lancet Psychiatry (free)

Commentaries: Understanding AVATAR therapy: who, or what, is changing? – The Lancet Psychiatry (free) AND Avatars can help schizophrenia patients control threatening voices – Reuters (free) Avatar therapy ‘reduces power of schizophrenia voices’ – BBC (free)

 

5 – Cause-specific mortality for 249 causes in Brazil and states during 1990–2015: a systematic analysis for the global burden of disease study 2015 – Population Health Metrics (free) (via @PauloLotufo)

 

6 – Medical News & Perspectives: Loneliness Might Be a Killer, but What’s the Best Way to Protect Against It? – JAMA (free)

Commentary: How Do We Prevent Loneliness? – Made in America (free)

 

7 – Blood pressure self-monitoring works best when people are well-supported – NIHR Signal (free)

Original article: Self-monitoring of blood pressure in hypertension: a meta-analysis – PLOS Medicine (free)

 

8 – Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

Source: ACP Journal Wise ($)

“Receipt of prolonged infusion of piperacillin-tazobactam was associated with reduced mortality and improved clinical cure rates across diverse cohorts of severely ill patients”.

 

9 – Seven-year tolerability profile of glucocorticoids use in early rheumatoid arthritis: data from the ESPOIR cohort – Annals of Rheumatic Diseases (free)

Commentaries: Long-Term Safety of Glucocorticoids in Patients with Early Rheumatoid Arthritis – Journal Watch (free) AND Long-term Low-dose Steroids OK in Early RA – MedPage Today (free registration required)

“Long-Term Safety of Glucocorticoids in Early Rheumatoid Arthritis. Stopping steroids completely is difficult in patients whose disease flares with tapering, but low-dose levels are relatively safe” (RT @JWatch see Tweet)

 

10 – Blood Pressure Status in Adult Survivors of Childhood Cancer: A Report from the St. Jude Lifetime Cohort Study – Cancer Epidemiology, Biomarkers & Prevention (link to abstract – $ for full-text)

Commentaries: Adult Survivors of Childhood Cancer Are More Likely to Develop High Blood Pressure – American Association for Cancer Research (free) AND Childhood cancer survivors 70% likely to develop hypertension as adults – Cardiovascular Business (free)

Related Guideline: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free)

 


 

1 – Living systematic review series published in Journal of Clinical Epidemiology (free articles)

– News Release – Cochrane Community (free)

– Living systematic review: 1. Introduction—the why, what, when, and how (free)

– Living systematic reviews: 2. Combining human and machine effort (free)

– Living systematic reviews: 3. Statistical methods for updating meta-analyses (free)

– Living systematic reviews: 4. Living guideline recommendations (free)

See also Cochrane Community Page on Living Systematic Reviews with updates and resources

“Living Systematic Reviews are future of all Reviews” (RT @PaulGlasziou see Tweet)

 

2 – Thyroid Function and the Risk of Atherosclerotic Cardiovascular Morbidity and Mortality: The Rotterdam Study – Circulation Research (free PDF)

Commentaries: Higher thyroid hormone levels associated with artery disease and death – AHA/ASA Newsroom (free) AND High Thyroid-Hormone Levels Linked to Increased CVD Mortality – Medscape (free registration required)

 

3 – 2017 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary – Resuscitation (free)

Commentary: Updated International Guidelines for Ventilation During CPR – Journal Watch (free)

 

4 – Inappropriate Management of Asymptomatic Patients With Positive Urine Cultures: A Systematic Review and Meta-analysis – Open Forum Infectious Diseases (free)

“OFID: Despite guidelines, continued overtreatment of patients with positive urine cultures but no symptoms” (RT @IDSAInfo see Tweet)

 

5 – Predictors of pneumonia in lower respiratory tract infections: 3C prospective cough complication cohort study – European Respiratory Journal (free)

Commentaries: Four clinical signs can improve GP pneumonia diagnosis, finds study – Pulse (free) AND Four simple tests could help GPs spot pneumonia and reduce unnecessary antibiotics – European Lung Fundation, via EurekAlert (free)

 

6 – Systematic Review and Meta-analysis Comparing the Efficacy of Nonsteroidal Anti-inflammatory Drugs, Opioids, and Paracetamol in the Treatment of Acute Renal Colic – European Urology (free) (via @KariTikkinen and @EUplatinum)

In kidney stone–related acute pain episodes in patients with adequate renal function, treatment with nonsteroidal anti-inflammatory drugs offers effective and most sustained pain relief, with fewer side effects, when compared with opioids or paracetamol”.

 

7 – Multidrug resistant (or antimicrobial-resistant) pathogens – alternatives to new antibiotics? – Swiss Medical Weekly (free)

 

8 – Point-of-use fortification of foods with micronutrient powders containing iron in children of preschool and school-age – Cochrane Library (link to summary – $ for full-text)

Powdered vitamins and minerals added to foods at the point-of-use reduces anaemia and iron deficiency in preschool- and school-age children”.

 

9 – High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis – Critical Care (free)

 

10 – Comprehensive assessment when older people are in hospital improves their chances of getting home and living independently – NIHR Signal (free)

Original article: Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (free summary – $ for full-text) AND News Release: Comprehensive geriatric assessment for older adults admitted to hospital (free)

“Comprehensive assessment when older people are in hospital improves their chances of getting home and living independently” (RT @NIHR_DC see Tweet)

 


 

1 – Children, Adolescents and Screens: What We Know and What We Need To Learn – Pediatrics Supplement (free articles)

– Table of contents

– Introduction

– Digital Screen Media and Cognitive Development

– Media Multitasking and Cognitive, Psychological, Neural, and Learning Differences

– Benefits and Costs of Social Media in Adolescence

– Digital Life and Youth Well-being, Social Connectedness, Empathy, and Narcissism

– Digital Media, Anxiety, and Depression in Children

– Internet Gaming Disorder in Children and Adolescents

– Virtual Reality in Pediatric Psychology

– Digital Media and Sleep in Childhood and Adolescence

– Screen Media Exposure and Obesity in Children and Adolescents

– Digital Media and Risks for Adolescent Substance Abuse and Problematic Gambling

– Small Screen Use and Driving Safety

– Parenting and Digital Media

– Children’s Privacy in the Big Data Era: Research Opportunities

– Developing Digital and Media Literacies in Children and Adolescents

– Digital Media, Participatory Politics, and Positive Youth Development

– Digital Inequality and Developmental Trajectories of Low-income, Immigrant, and Minority Children

– Global Perspectives on Children’s Digital Opportunities: An Emerging Research and Policy Agenda

– Screen Violence and Youth Behavior

– Defining Cyberbullying

The Effect of Advertising on Children and Adolescents

– Social Group Stories in the Media and Child Development

– Sexual Media and Childhood Well-being and Health

 

2 – Combination Therapy Is Superior to Sequential Monotherapy for the Initial Treatment of Hypertension: A Double‐Blind Randomized Controlled Trial – Journal of The American Heart Association (free)

“Initial combination therapy can be recommended for patients with BP >150/95 mm Hg”

 

3 – Coffee consumption and health: umbrella review of meta-analyses of multiple health outcomes – The BMJ (free)

Editorial: Coffee gets a clean bill of health (free)

Commentaries: Moderate coffee drinking ‘more likely to benefit health than to harm it’ say experts – The BMJ, via EurekAlert (free) AND Coffee: No Harm, No Foul If Only 4 Cups Daily – MedPage Today (free registration required)

 

4 – Oxygen therapy for acute myocardial infarction: A systematic review and meta-analysis – International Journal of Nursing Studies (link to abstract – $ for full-text)

Source: Supplemental Oxygen Is Associated with Excess Risk for Recurrent Myocardial Infarction – Journal Watch ($)

See related article – “Oxygen Therapy in Suspected Acute Myocardial Infarction” – and commentaries in our August 29th issue (see #1)

“Supplemental Oxygen Associated w/ Excess Risk for Recurrent Myocardial Infarction. It’s time to stop the free flow of oxygen when not absolutely needed” (RT @JWatch see Tweet)

 

5 – An International Consortium Update: Pathophysiology, Diagnosis, and Treatment of Polycystic Ovarian Syndrome in Adolescence – Hormone Research in Paediactrics (free)

 

6 – Richard Smith: How might artificial intelligence improve healthcare? – The BMJ Opinion (free)

 

7 – Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free)

 

8 – Sugar industry sponsorship of germ-free rodent studies linking sucrose to hyperlipidemia and cancer: An historical analysis of internal documents – PLOS Biology (free)

Commentaries: What The Industry Knew About Sugar’s Health Effects, But Didn’t Tell Us – NPR (free) AND Sugar Industry Long Downplayed Potential Harms – The New York Times (10 articles per month are free) AND Big Sugar Buried These Concerning Health Studies 50 Years Ago – ScienceAlerts (free) AND Sugar Industry Suppressed Evidence of Health Risks of Sucrose – UC San Francisco (free)

 

9 – As Malaria Resists Treatment, Experts Warn of Global Crisis – The New York Times (10 articles per month are free)

 

10 – Effects of Sodium Reduction and the DASH Diet in Relation to Baseline Blood Pressure – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: DASH Diet, Sodium, and Baseline Blood Pressure – Latest in Cardiology, American College of Cardiology (free) AND Big BP Reductions When DASH Diet Combined With Low Sodium Intake – TCTMD (free)

 


 

1 – Arthroscopic subacromial decompression for subacromial shoulder pain (CSAW): a multicentre, pragmatic, parallel group, placebo-controlled, three-group, randomised surgical trial – The Lancet (free)

Editorial: No benefit of arthroscopy in subacromial shoulder pain (free)

Commentaries: Common shoulder surgery may offer little pain relief – OnMedica (free) AND Is a common shoulder surgery useless? – MedicalXpress (free) AND Popular Surgery To Ease Chronic Shoulder Pain Called Into Question – NPR (free)

 

2 – Hepatitis B Vaccination, Screening, and Linkage to Care: Best Practice Advice From the American College of Physicians and the Centers for Disease Control and Prevention – Annals of Internal Medicine (free)

Commentaries: ACP, CDC issue best practice advice on HBV – ACP Internist (free) AND CDC, ACP Offer Joint Guidance on Hepatitis B Vaccination and Screening – Physician’s First Watch (free)

 

3 – Management of Tiny Unruptured Intracranial Aneurysms: A Comparative Effectiveness Analysis – JAMA Neurology (free)

Editorial: Leaving Tiny, Unruptured Intracranial Aneurysms Untreated: Why Is It So Hard? (free)

 

4 – Association of Hormonal Contraception With Suicide Attempts and Suicides – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Hormonal Contraception May Increase Risk of Suicide, Study Suggests – Psychiatric News Alert (free) AND Oral Contraceptives Linked to Suicide – Medscape (free registration required)

 

5 – 2017 SEOM clinical guideline for treatment of cancer pain – Clinical and Translational Oncology (free)

 

6 – Proportion and number of cancer cases and deaths attributable to potentially modifiable risk factors in the United States – CA: A Cancer Journal for Clincians (free)

Commentaries: Cancer: 42 percent of cases down to risk factors you can change – Medical News Today (free) AND Preventable Cancer Estimate Reaches 40% – MedPage Today (free registration required)

 

7 – New Choosing Wisely Canada list: Six Things Pharmacists and Patients Should Question (RT @CPhAAPhC see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

 

8 – Deprescribing antihyperglycemic agents in older persons: Evidence-based clinical practice guideline – Canadian Family Physician (free)

Related algorithm: Antihyperglycemic deprescribing algorithm (free PDF)

See also other Deprescribing Guidelines and Algorithms (free resources)

 

9 – Detecting hip fractures with radiologist-level performance using deep neural networks – Cornell University Library (free)

Related: CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning – Stanford ML Group (free)

 

10 – Conjoint Associations of Gestational Diabetes and Hypertension With Diabetes, Hypertension, and Cardiovascular Disease in Parents: A Retrospective Cohort Study – American Journal of Epidemiology (free)

Invited Commentary: Gestational Hypertension and Diabetes—A Major Public Health Concern (free)

Commentaries: Pregnancy-related conditions taken together leave moms — and dads — at risk – McGill University Health Centre, via EurekAlert (free) AND Gestational Diabetes and Hypertension = Huge Risk for Later Disease – Medscape (free registration required)

 


 

1 – Development and validation of QDiabetes-2018 risk prediction algorithm to estimate future risk of type 2 diabetes: cohort study – The BMJ (free) (RT @JuliaHCox see Tweet)

See QDiabetes 2018 risk calculator (free)

 

2 – Clinical Guidelines Synopsis: Prevention, Detection, Evaluation, and Management of High Blood Pressure in Adults – JAMA (free)

Editorial: The New 2017 ACC/AHA Guidelines “Up the Pressure” on Diagnosis and Treatment of Hypertension (free)

Related Viewpoint: The 2017 Clinical Practice Guideline for High Blood Pressure (free)

See original AHA/ACC Hypertension Guidelines and related resources in our November 13th issue (see #1)

 

3 – Policy Statement: Stigma Experienced by Children and Adolescents With Obesity – American Academy of Pediatrics (free)

News release: The AAP and the Obesity Society Address the Social and Emotional Impact of Weight Stigma on Children and Teens (free)

Commentaries: Help obese kids avoid weight stigma, doctors advise – Reuters (free) AND How Not to Talk to a Child Who Is Overweight – The New York Times (10 articles per month are free)

 

4 – Association between maternal sleep practices and late stillbirth – findings from a stillbirth case-control study – British Journal of Obstetrics and Gynaecology (free)

Commentary: Stillbirth risk doubled in women sleeping on their back – OnMedica (free) AND Women advised to sleep on side to help prevent stillbirth – BBC (free)

 

5 – Direct medical costs of motorcycle crashes in Ontario – Canadian Medical Association Journal (free)

Commentaries: Motorcycle crashes cause 5 times as many deaths as car accidents, 6 times the health costs – CMAJ, via EurekAlert (free) AND Motorcycle crashes are alarmingly common — and incredibly costly – STAT (free)

 

6 – Elimination of schistosomiasis: the tools required – Infectious Diseases of Poverty (free)

 

7 – Current and new challenges in occupational lung diseases – European Respiratory Review (free)

 

8 – Richard Lehman’s journal review, 20 November 2017 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Practical Considerations for the Diagnosis and Management of Asthma in Older Adults – Mayo Clinic Proceedings (free)

 

10 – Pharmacologic management of chronic neuropathic pain: Review of the Canadian Pain Society consensus statement – Canadian Family Physician (free)

Related article: Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free)

 


 

1 – News release: New global commitment to end tuberculosis – World Health Organization (free)

Commentary: Global health ministers commit to end TB – CIDRAP (free)

Related report: Global tuberculosis report 2017 – World Health Organization (free) AND News Release: WHO report signals urgent need for greater political commitment to end tuberculosis (free)

 

2 – Infection prevention and control measures and tools for the prevention of entry of carbapenem-resistant Enterobacteriaceae into healthcare settings: guidance from the European Centre for Disease Prevention and Control – Antimicrobial Resistance & Infection Control (free)

Related document: Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosain health care facilities – World Health Organization (free)

 

3 – The association between paternal and adolescent depressive symptoms: evidence from two population-based cohorts – The Lancet (free)

Editorial: The effect of paternal depression on depressive symptoms in adolescent offspring (free)

Commentaries: Dads’ Depression Tied to Increased Depression Risk in Teenage Children – Physician’s First Watch (free) AND Teenage depression linked to father’s depression – University College London, via ScienceDaily (free)

 

4 – The High Costs of Unnecessary Care – JAMA (free)

 

5 – “Maybe I Will Just Send a Quick Text…” – An Examination of Drivers’ Distractions, Causes, and Potential Interventions – Frontiers in Psycology (free)

Commentaries: Young Men, Frequent Drivers Most Likely To Get Distracted While Driving – NPR (free) AND Risk of distracted driving predicted by age, gender, personality and driving frequency – MedicalXpress (free)

 

6 – Dog ownership and the risk of cardiovascular disease and death – a nationwide cohort study – Scientific Reports (free)

Commentaries: Dog ownership linked to lower mortality – Uppsala University, via ScienceDaily (free) AND Owning A Dog May Help Your Heart, Study Shows – Forbes (free)

 

7 – Bird Flu Is Spreading in Asia, Experts (Quietly) Warn – The New York Times (10 articles per month are free)

 

8 – Taking Care of the Physician – The New York Times (10 articles per month are free)

 

9 – Pearls and pitfalls in comprehensive critical care echocardiography – Critical Care (free)

 

10 – Validation of the Ottawa Subarachnoid Hemorrhage Rule in patients with acute headache – Canadian Medical Association Journal (free)

Commentaries: Thunderclap Headache: Ottawa Rule To Exclude Subarachnoid Bleeding – Medical Research (free) AND New tool identifies headache patients at risk of aneurysms in emergency department – CMAJ, via EurekAlert (free)

 


 

1 – Exploring Attributes of High-Value Primary Care – Annals of Family Medicine (free)

Commentaries: Lower cost, higher quality primary care practices are distinguished by six attributes – American Academy of Family Physicians, via ScienceDaily (free) AND Identifying ‘high-value’ practices in primary care; a Stanford study pinpoints key attributes – Stanford Medicine (free)

 

2 – Critical Lessons From High-Value Oncology Practices – JAMA Oncology (free)

Editorial: Strategies to Achieve High-Value Oncology Care: A Beginning (free)

Audio interview: Critical Lessons From High-Value Oncology Practices (free)

Commentary: High-Value Cancer Care Keeps Costs Down? Yes, It’s Possible! – Medscape (free registration required) AND High-value oncology practices include “support for the patient journey” – Stanford Medicine (free)

 

3 – Changing Health Care Compensation by Rewarding Value-Based Outcomes – NEJM Catalyst (free)

 

4 – Speed of processing training results in lower risk of dementia – Alzheimer’s & Dementia: Translational Research & Clinical Interventions (free)

Commentaries: Can brain training reduce dementia risk? Despite new research, the jury is still out – The Guardian (free) AND Nonpharma Intervention Cuts Dementia Risk by a Third – Medscape (free registration required) AND Dementia breakthrough? Brain-training game ‘significantly reduces risk’ – Medical News Today (free)

“There are good reasons to be cautious about a new study claiming computer-based training can reduce the risk of dementia. But what does work?” (from The Guardian).

 

5 – Timing of Angiography and Outcomes in High-Risk Patients With Non–ST-Segment–Elevation Myocardial Infarction Managed Invasively – Circulation (free)

“High risk NSTEMI undergoing cath within 12 hours had lower risk of death and MI at 180 days” (RT @CircAHA see Tweet)

 

6 – Why we should care that many editors of top medical journals get healthcare industry payments – Health News Reviews (free)

Original article: Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study – The BMJ (free)

 

7 – Review: Undernutrition and severe acute malnutrition in children – The BMJ (free)

Infographic: Screening and referring children under 5 years old with acute undernutrition (free PDF)

 

8 – Review: Diabetic foot – The BMJ (free)

Infographic: A visual overview of the primary care assessment and monitoring of a diabetic foot (free PDF)

 

9 – Review of Strategies to Reduce Central Line-Associated Bloodstream Infection (CLABSI) and Catheter-Associated Urinary Tract Infection (CAUTI) in Adult ICUs – Journal of Hospital Medicine (free) (via @brhospitalist)

 

10 – Simple steps help prevent ICU delirium – ACP Hospitalist (free)

 


 

1 – Periodic preventive health visits: a more appropriate approach to delivering preventive services – Canadian Task Force on Preventive Health Care (free)

Summary: Periodic preventive health visits: A more appropriate approach to delivering preventive services (free)

News release: Annual checkups do not result in better health outcomes, national task force reaffirms (free)

 

2 – Sudden Cardiac Arrest during Participation in Competitive Sports – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Sudden Cardiac Arrest Rare During Competitive Sports – Physician’s First Watch (free) AND Cardiac arrest study in young athletes raises heart screening questions – Reuters (free) AND Cardiac Arrest Rare in Young Athletes But Tough to Predict – Health (free) AND Screening programs unlikely to prevent sudden cardiac arrest in competitive athletes – St. Michael’s Hospital, via EurekAlert (free)

 

3 – Guidelines for the prevention and control of carbapenem-resistant Enterobacteriaceae, Acinetobacter baumannii and Pseudomonas aeruginosain health care facilities – World Health Organization (free)

Commentary: WHO offers guidance on carbapenem-resistant bacteria – CIDRAP (free)

 

4 – CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning – Stanford ML Group (free)

We develop an algorithm that can detect pneumonia from chest X-rays at a level exceeding practicing radiologists

 

5 – The Patients vs. Paperwork Problem for Doctors – The New York Times (10 articles per month are free)

Related guideline: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

 

6 – World Chronic Obstructive Pulmonary Disease Day, 15 November 2017: A round up of Cochrane evidence – Evidently Cochrane (free)

 

7 – Comparative clinical effectiveness and cost effectiveness of endovascular strategy vopen repair for ruptured abdominal aortic aneurysm: three year results of the IMPROVE randomised trial – The BMJ (free)

Editorial: Endovascular or open repair for ruptured abdominal aortic aneurysm? (free)

Commentary: Keyhole surgery more effective than open surgery for ruptured aneurysm – MedicalXpress (free)

 

8 – Health Effects and Public Health Concerns of Energy Drink Consumption in the United States: A Mini-Review – Frontiers in Public Health (free)

Commentaries: Serious health risks associated with energy drinks – ScienceDaily (free)

“To curb this growing public health issue, policy makers should regulate sales and marketing towards children and adolescents and set upper limits on caffeine” (from ScienceDaily)

 

9 – Effects of Bariatric Surgery in Obese Patients With Hypertension: The GATEWAY Randomized Trial (Gastric Bypass to Treat Obese Patients With Steady Hypertension) – Circulation (free)

Commentary: Bariatric Surgery Can Lead to HTN ‘Remission’ in Obese: GATEWAY – Medscape (free registration required) AND Gastric Bypass to Treat Obese Patients With Steady Hypertension – GATEWAY – American College of Cardiology, Latest in Cardiology (free)

 

10 – Effects of weight loss interventions for adults who are obese on mortality, cardiovascular disease, and cancer: systematic review and meta-analysis – The BMJ (free)

 


 

1 – Association of Blood Pressure Lowering With Mortality and Cardiovascular Disease Across Blood Pressure Levels: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Treating modestly high blood pressure may not boost survival odds – Reuters (free) AND No cardiovascular disease reduction with intensive blood pressure lowering treatment – Umea University, via EurekAlert (free)

See also new AHA/ACC Hypertension Guidelines and related resources in our November 13th issue (see #1)

“”Primary preventive BP lowering is associated with reduced risk for death and CVD if baseline SBP is 140 mm Hg or higher.” published same day as @ACCinTouch guideline w/SBP goals <130 mm Hg. Cognitive dissonance?” (RT @kennylinafp see Tweet)

 

2 – Noninvasive Cardiac Testing vs Clinical Evaluation Alone in Acute Chest Pain: A Secondary Analysis of the ROMICAT-II Randomized Clinical Trial – JAMA Internal Medicine (free)

Editorial: Acute Chest Pain in the Emergency Department (free)

Commentaries: Does Clinical Evaluation Plus Noninvasive Cardiac Testing Improve Outcomes in Emergency Department Patients with Chest Pain? – The JAMA Network (free) AND Noninvasive Cardiac Testing No Better Than Clinical Eval for Low-Risk Acute Chest Pain – Physician’s First Watch (free)

“Non-invasive testing of chest pain patients in the ED – longer stay; more testing, radiation and cost; no benefit”. (RT @JAMA_current see Tweet)

 

3 – World Antibiotic Awareness Week, 13-19 November 2017: A round up of Cochrane evidence – Evidently Cochrane (free)

 

4 – Guidelines on the management of abnormal liver blood tests – Gut (free)

 

5 – Increases in Depressive Symptoms, Suicide-Related Outcomes, and Suicide Rates Among U.S. Adolescents After 2010 and Links to Increased New Media Screen Time – Clinical Psychological Science (free)

Commentaries: Increased Hours Online Correlate With An Uptick In Teen Depression, Suicidal Thoughts – NPR (free) AND Smartphones a likely culprit in the recent decline in teen mental health – STAT (free)

 

6 – Tinder and Grindr don’t want to talk about their role in rising STDs – VOX (free)

 

7 – Review: The Diagnosis of Chronic Coronary Heart Disease – Deutsches Ärzteblatt international (free)

 

8 – Aspirin in Patients With Previous Percutaneous Coronary Intervention Undergoing Noncardiac Surgery – Annals of Internal Medicine (free)

Commentaries: Perioperative aspirin may improve short-term outcomes after noncardiac surgery in patients with prior PCI – ACP Internist (free) AND Aspirin can prevent heart attacks after noncardiac surgery in patients with prior PCI – University of Alberta Faculty of Medicine & Dentistry, via ScienceDaily (free) AND Aspirin Protective Against Early Death/MI in Prior PCI Patients Undergoing Noncardiac Surgery – TCTMD (free)

 

9 – Perinatal mortality associated with induction of labour versus expectant management in nulliparous women aged 35 years or over: An English national cohort study – PLOS Medicine (free)

Commentaries: Labor induction at 40 weeks associated with lower risk of perinatal mortality – PLOS, via ScienceDaily (free) AND Induction at Term Cuts Rates of Infant Death in Older First-Time Moms – MedPage Today (free registration required) Inducing Older Moms at 40 Weeks May Lower Stillbirth Risk – Medscape (free registration required)

 

10 – Effect of an Intervention to Promote Breastfeeding on Asthma, Lung Function, and Atopic Eczema at Age 16 Years: Follow-up of the PROBIT Randomized Trial – JAMA Pediatrics (free)

Commentary: Prolonged breastfeeding linked to halving of later eczema risk – OnMedica (free)

 


 

1 – 2017 ACC/AHA Guideline for the Prevention, Detection, Evaluation and Management of High Blood Pressure in Adults (free PDF)

See also: High Blood Pressure Guidelines Hub / Executive Summary / ACC/AHA Slide Set / ACC Key Points to Remember (free resources)

 

2 – Outcomes after Angiography with Sodium Bicarbonate and Acetylcysteine – New England Journal of Medicine (free)

Commentaries: Neither Sodium Bicarbonate nor Oral Acetylcysteine Prevents Contrast-Induced Kidney Injury – Physician’s First Watch (free) AND PRESERVE: No Benefit from Sodium Bicarbonate, Acetylcysteine After Angiography – Medscape (free registration required)

 

3 – Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery – New England Journal of Medicine (free)

Commentaries: TRICS III: Restrictive Red-Cell Transfusion Noninferior to Liberal Use in Cardiac Surgery – TCTMD (free) AHA: Restrictive Blood Transfusion OK for Select Patients – MedPage Today (free registration required)

Related article: Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA (free)

 

4 – Sexual Activity as a Trigger for Sudden Cardiac Arrest – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Sex poses little risk of triggering sudden cardiac arrest – Cedars-Sinai Heart Institute, via EurekAlert (free) AND Instances of cardiac arrest after sex are low, but so are the survival rates – Cardiovascular Business (free)

 

5 – Comparison of Hospital Resource Use and Outcomes Among Hospitalists, Primary Care Physicians, and Other Generalists – JAMA Internal Medicine (free)

Editorial: The Costs and Benefits of Hospital Care by Primary Physicians: Continuity Counts (free)

Audio interview: Hospital Resource Use and Outcomes Among Generalist Physicians (free)

Commentaries: Study: For Inpatients, Primary Care Docs Outperform Hospitalists – MedPage Today (free registration required) AND Mortality Lower When Inpatients See Their Own PCP in Hospital – Medscape (free registration required)

 

6 – Review: Eosinophilic esophagitis: update on management and controversies – The BMJ (free for 2 weeks)

 

7 – Risks for blood clot in a vein may rise with increased TV viewing – Presented at American Heart Association’s (AHA) Scientific Sessions 2017 (free)

Commentary: More TV viewing linked to higher risk of blood clots in veins – Medical News Today (free)

 

8 – Nut Consumption and Risk of Cardiovascular Disease – Journal of The American College of Cardiology (free)

Commentary: Eating Regular Variety of Nuts Associated With Lower Risk of Heart Disease – American College of Cardiology (free) AND Variety of nuts tied to lower risk of heart disease – Reuters (free)

 

9 – Richard Lehman’s journal review, 13 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

10 – 20-Year Risks of Breast-Cancer Recurrence after Stopping Endocrine Therapy at 5 Years – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: ‘Unrelenting': 20-Year Recurrence Risks in Breast Cancer – Medscape (free registration required) AND Breast cancer recurrence risk lingers years after treatment ends – MedicalXpress (free) AND Risk of breast cancer’s return continues long after treatment ends – Medical News Today (free)

 


 

1 – World Antibiotic Awareness Week, 13-19 November 2017 – World Health Organization (free resources)

 

2 – Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct – New England Journal of Medicine (free)

Editorial: A New DAWN for Imaging-Based Selection in the Treatment of Acute Stroke (free)

Commentaries: Landmark study may impact standard stroke treatment guidelines – MedicalXpress (free) AND Thrombectomy Works While Infarct Core is Small – MedPage Today (free registration required)

“DAWN data: Consider a “tissue window” rather than a “time window”” (from MedPage Today)

 

3 – Mechanical or Biologic Prostheses for Aortic-Valve and Mitral-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Mechanical heart valve often the safest choice – Stanford Medicine (free) AND Mechanical or Biologic Prostheses for Aortic-Valve and Mitral-Valve Replacement? – NEJM 360 Resident (free) AND Mechanical or Tissue Valve for AVR and MVR – American College of Cardiology, Latest in Cardiology (free) AND Mechanical Valves Show Mortality Benefit Over Biologic Valves – Medscape (free registration required) AND Heart valve replacement success may depend on age, valve type – Reuters (free)

 

4 – NICE Guideline: Bipolar disorder: assessment and management (free)

 

5 – Choice of implant combinations in total hip replacement: systematic review and network meta-analysis – The BMJ (free)

Commentary: What is the most effective type of hip implant combination for patients undergoing a hip replacement? – University of Bristol (free)

“…there is no evidence that any of the newer hip implant combinations, such as ceramic or uncemented, are better than the widely used small head metal-on-plastic cemented hip combination, which has been commonly used since the 1960s”.

 

6 – White Smoke From the Vatican? Not From Cigarettes – The New York Times (10 articles per month are free)

Related: No more Holy Smokes – Vatican bans sale of cigarettes – Reuters (free) AND Holy smoke: Vatican bans duty-free cigarette sales – BBC (free)

“WHO welcomes the Vatican’s decision to ban the sale of cigarettes as of next year. Tobacco kills more than 7 million people every year” (RT @WHO see Tweet)

 

7 – Exercise for the Prevention of Low Back Pain: Systematic Review and Meta-Analysis of Controlled Trials – American Journal of Epidemiology (link to abstract – $ for full-text)

Commentary: Exercise may help prevent low back pain or make it less severe – Reuters (free)

Related meta-analysis: Prevention of Low Back Pain: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free)

 

8 – How to survive the medical misinformation mess – European Journal of Clinical Investigation (free) (RT @RasoiniR see Tweet)

 

9 – Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study – The BMJ (free)

Commentary: Vitamin D level not associated with cancer risk – Clinical Adviser (free)

“These results, in combination with previous literature, provide evidence that population-wide screening for vitamin D deficiency and subsequent widespread vitamin D supplementation should not currently be recommended as a strategy for primary cancer prevention”.

 

10 – Long-term Sustainability of Diabetes Prevention Approaches: A Systematic Review and Meta-analysis of Randomized Clinical Trials – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Lifestyle Modifications Slow Progression To Diabetes As Effectively As Medications – Medical Research (free) AND Lifestyle changes successfully reduce incidence of diabetes – MedicalXpress (free) AND Lifestyle changes—not medications—linked to sustained risk reduction for diabetes – Cardiovascular Business (free)

 


 

1 – European guidelines on perioperative venous thromboembolism prophylaxis – European Journal of Anaesthesiology (free PDF articles):

– Editorial

– Executive Summary

– Intensive care

– Mechanical prophylaxis

– Patients with preexisting coagulation disorders and after severe perioperative bleeding

– Inferior vena cava filters

– Cardiovascular and thoracic surgery

– Neurosurgery

– Surgery in the elderly

– Surgery in the obese patient

– Surgery during pregnancy and the immediate postpartum period

– Day surgery and fast-track surgery

– Chronic treatments with antiplatelet agents

– Aspirin

 

2 – Vancomycin Plus Piperacillin-Tazobactam and Acute Kidney Injury in Adults: A Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Vancomycin plus piperacillin-tazobactam associated with higher AKI risk – ACP Hospitalist (free)

Related article: Association of Acute Kidney Injury With Concomitant Vancomycin and Piperacillin/Tazobactam Treatment Among Hospitalized Children – JAMA Pediatrics (link to abstract – $ for full-text)

 

3 – 2017 Comprehensive Update of the Canadian Cardiovascular Society Guidelines for the Management of Heart Failure (free)

 

4 – Clinical Practice Guideline of Korean Diabetes Association (free articles):

– Antihyperglycemic Agent Therapy for Adult Patients with Type 2 Diabetes Mellitus 2017

– Insulin Therapy for Adult Patients with Type 2 Diabetes Mellitus

– Monotherapy in Patients with Type 2 Diabetes Mellitus

– Combination Therapy of Oral Hypoglycemic Agents in Patients with Type 2 Diabetes Mellitus

 

5 – 2017 Multimodality Appropriate Use Criteria for Noninvasive Cardiac Imaging: Expert Consensus of the Asian Society of Cardiovascular Imaging – Korean Journal of Cardiology (free)

 

6 – Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research – The Lancet Neurology (free registration required)

 

7 – Being overweight or obese is linked with heart disease even without other metabolic risk factors – NIHR Signal (free)

Original article: Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis – European Heart Journal (free)

 

8 – Receipt of Warnings Regarding Potentially Impairing Prescription Medications and Associated Risk Perceptions in a National Sample of U.S. Drivers – Journal of Studies on Alcohol and Drugs (free)

Commentaries: Drivers not always told about their prescriptions’ potentially impairing effects – ACP Internist (free) AND Many People Prescribed Drugs That Could Impair Driving Aren’t Warned About Risk – Physician’s First Watch (free)

 

9 – Cardiovascular Effects of Long‐Term Exposure to Air Pollution: A Population‐Based Study With 900 845 Person‐Years of Follow‐up – Journal of The American Heart Association (free)

Commentaries: Air pollution as great a risk as hypertension, obesity, diabetes for CVD – Cardiovascular Business (free)

 

10 – Pulse oximetry screening for critical congenital heart defects: a European consensus statement – The Lancet Child & Adolescent Health (free)

Commentaries: All babies in Europe should be screened for heart defects at birth – OnMedica (free) AND Call for Europe-wide screening of babies for heart defects – MedicalXpress (free)

 


 

1 – Book: Major Infectious Diseases: Disease Control Priorities, Third Edition (free)

Press Release: Disease Control Priorities, 3rd Edition Launches Major Infectious Diseases Volume (free)

Previous volumes: 1 – Essential Surgery / 2 – Reproductive, Maternal, Newborn, and Child Health / 3 – Cancer / 4 – Mental, Neurological, and Substance Use Disorders / 5 – Injury Prevention and Environmental Health (all free)

 

2 – Inflammatory Bowel Disease, 4th Edition – Australian Guidelines for General Practitioners and Physicians (free PDF)

Source: Gastroenterology Research Review Australia

 

3 – Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)

Editorial: Antibiotics or NSAIDs for uncomplicated urinary tract infection? (free)

Commentary: NSAID Compared to Antibiotic for Symptomatic Treatment of UTI – MPR (free)

 

4 – Regeneration of the entire human epidermis using transgenic stem cells – Nature (link to abstract – $ for full-text)

Commentaries: A Dying Boy Gets a New, Gene-Corrected Skin – The Atlantic (free) Gene Therapy Creates Replacement Skin to Save a Dying Boy – The New York Times (10 articles per month are free) AND ‘Extraordinary’ tale: Stem cells heal a young boy’s lethal skin disease – STAT (free) AND Scientists grow replacement skin for boy suffering devastating genetic disorder – The Guardian (free) Boy with rare disease gets brand new skin with gene therapy – Associated Press (free)

 

5 – International variations in primary care physician consultation time: a systematic review of 67 countries – BMJ Open (free)

Commentary: Primary care consultations last less than 5 minutes for half the world’s population – BMJ, via ScienceDaily (free)

“Global assessment of the length of doctor visits (primary care): range of 48 seconds to 22 minutes” (RT @EricTopol see Tweet)

 

6 – The case against hospital beds – Politico (free)

 

7 – Pre-exposure prophylaxis for HIV-negative persons with partners living with HIV: uptake, use, and effectiveness in an open-label demonstration project in East Africa – Gates Open Research (free)

 

8 – Medications That Cause Dry Mouth As an Adverse Effect in Older People: A Systematic Review and Metaanalysis – Journal of The American Geriatrics Society (free)

Commentaries: Dry mouth symptoms can be side effect of certain medications for older adults – American Geriatrics Society, via EurekAlert (free) AND Certain medication use associated with dry mouth in older adults – Clinical Advisor (free)

 

9 – Coronary Artery Calcium Score for Long-term Risk Classification in Individuals With Type 2 Diabetes and Metabolic Syndrome From the Multi-Ethnic Study of Atherosclerosis – JAMA (free)

Commentaries: Risk Classification by CAC Score in Diabetes and Metabolic Syndrome – American College of Cardiology, Latest in Cardiology (free) AND CAC Score Aids in CVD Risk Prediction in Diabetes – MedPage Today (free registration required)

 

10 – Viewpoint: Placebo Effect of the Heart – The Atlantic (free)

Related viewpoints: 12 Seconds of Placebo – An Outsider’s View of ORBITA – The HealthCare Blog (free) AND ORBITA Trial Puts Interventional Cardiologists On The Defensive – Cardiobrief (free) AND ORBITA: Another clinical trial demonstrating the need for sham controls in surgical trials – Science-Based Medicine (free) AND Coronary Stents Humbled Yet Again in Stable CAD – Medscape (free)

See original ORBITA trial and commentaries in our November 3rd issue (see #1)

  


 

1 – News Release and Summary: More Cardiac Arrest Victims Could Survive with Dispatcher CPR Instruction, Rescue Breaths for Children (free)

See Guidelines: 2017 International Consensus on Cardiopulmonary Resuscitation and Emergency Cardiovascular Care Science With Treatment Recommendations Summary (free PDF) AND 2017 American Heart Association Focused Update on Adult Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF) AND 2017 American Heart Association Focused Update on Pediatric Basic Life Support and Cardiopulmonary Resuscitation Quality (free PDF)

Top Ten Things to Know: AHA Focused Update on Adult and Pediatric Basic Life Support and CPR Quality (free PDF)

 

2 – WHO guidelines on use of medically important antimicrobials in food-producing animals – World Health Organization (free)

News release: Stop using antibiotics in healthy animals to prevent the spread of antibiotic resistance (free)

Related Article: Restricting the use of antibiotics in food-producing animals and its associations with antibiotic resistance in food-producing animals and human beings: a systematic review and meta-analysis – The Lancet Planetary Health (free) and Editorial: Antimicrobial use and resistance in animals and human beings (free)

Commentaries: WHO calls for restrictions on use of antibiotics in food animal production – STAT (free) AND WHO Moves to Contain Superbugs on the Farm – Scientific American (free) WHO calls for an end to antibiotic use in healthy animals – CIDRAP (free)

 

3 – Effect of treatment delay on the effectiveness and safety of antifibrinolytics in acute severe haemorrhage: a meta-analysis of individual patient-level data from 40 138 bleeding patients – The Lancet (free)

Commentaries: Tranexamic acid: is it about time? – The Lancet (free) Rapid use of blood drug could save thousands of lives, study finds – The Guardian (free) AND Severely bleeding patients must receive lifesaving drug within minutes, not hours – London School of Hygiene & Tropical Medicine, via EurekAlert (free)

 

4 – Draft Recommendation Statement: Osteoporosis to Prevent Fractures: Screening – U.S. Preventive Services Task Force (free)

Commentary: New USPSTF Draft Recommendations for Osteoporosis Screening – Medscape (free registration required)

 

5 – Effect of a Single Dose of Oral Opioid and Nonopioid Analgesics on Acute Extremity Pain in the Emergency Department: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: No Significant Difference in Pain Relief for Opioids vs Non-Opioid Analgesics for Treating Arm or Leg Pain – The JAMA Network (free) AND Acetaminophen plus Ibuprofen Noninferior to Low-Dose Oral Opioids for Acute Extremity Pain – Journal Watch (free)

 

6 – Comparisons of Interventions for Preventing Falls in Older Adults: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Exercise, Vision Testing and Osteoporosis Evaluation Are Keys To Fall Prevention – Medical Research (free) AND Exercise may be best intervention to prevent falls among elderly, according to new study – MedicalXpress (free) AND Adding other therapy to exercise may be best for fall prevention – Reuters (free) AND How to Prevent Falls in Older Adults – Consumer Reports (free)

 

7 – Alcohol and Cancer: A Statement of the American Society of Clinical Oncology – Journal of Clinical Oncology (free)

Commentaries: Cancer Doctors Cite Risks of Drinking Alcohol – The New York Times (10 articles per month are free) AND Cutting back on alcohol can prevent cancers: experts – Reuters (free) ASCO links alcohol to cancer, calls for reduced consumption – eCancer News (free)

 

8 – The Growing Value of Digital Health: Evidence and Impact on Human Health and the Healthcare System – IQVIA Institute (free)

Commentary: Study Names Top Apps for Patients to Manage Illnesses – Medscape (free registration required)

“An impressive, in-depth report on digital health, shows how the field is taking hold” (RT @EricTopol see Tweet)

 

9 – Clinical Guidelines Synopsis: Screening for Chronic Obstructive Pulmonary Disease – JAMA (free)

Original Guideline: GOLD 2017  Global Strategy for the Diagnosis, Management and Prevention of COPD (free PDF)

Related Guidelines: Final Recommendation Statement: Chronic Obstructive Pulmonary Disease: Screening – U.S. Preventive Services Task Force (free) AND Diagnosis and Management of Stable Chronic Obstructive Pulmonary Disease: A Clinical Practice Guideline Update from the American College of Physicians, American College of Chest Physicians, American Thoracic Society, and European Respiratory Society (free)

 

10 – Projecting the impact of a nationwide school plain water access intervention on childhood obesity: a cost–benefit analysis – Pediatric Obesity (link to abstract – $ for full-text)

Commentaries: Making water available to school chilren at lunch may save $13B in health costs – UPI (free) AND Serving water with school lunches could curb obesity, save billions – Cardiovascular Business (free) AND Serving water with school lunches could prevent child, adult obesity: study – MedicalXpress (free)

 


 

1 – The Burden of Group B Streptococcus Worldwide for Pregnant Women, Stillbirths, and Children – Clinical Infectious Diseases Supplement (free articles)

Commentaries: Group B Streptococcus infection causes an estimated 150,000 preventable stillbirths and infant deaths every year – London School of Hygiene & Tropical Medicine (free) AND Streptococcus vaccine ‘could prevent over 100,000 baby deaths worldwide’ – The Guardian (free)

 

2 – Effectiveness of β-Lactam Monotherapy vs Macrolide Combination Therapy for Children Hospitalized With Pneumonia – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Study: Azithromycin overprescribed for kids’ pneumonia – CIDRAP (free) AND Vanderbilt study shows azithromycin overprescribed for childhood pneumonia – Vanderbilt University Medical Center, via EurekAlert (free)

 

3 – Position Paper: Patient Safety in the Office-Based Practice Setting – American College of Physicians (free PDF)

Commentaries: ACP says patient safety must be improved in office-based practice setting – American College of Physicians, via EurekAlert (free) AND ACP: Recommendations for Improving Patient Safety in Ambulatory Settings – MPR (free)

 

4 – Debate: the case for and against screening for breast cancer with mammography:

The case for mammography: Routine mammograms do save lives: The Science – The Conversation (free)

The case against mammography: Routine mammograms do not save lives: The research is clear – The Conversation (free)

Related: Make Screening Mammography Personal, Say the French – Medscape (free registration required)

“The debate over breast cancer screening continues, with disagreements about the start age, frequency, mortality effect, overdiagnosis, and overtreatment” (from Medscape)

 

5 – ORBITA: Another clinical trial demonstrating the need for sham controls in surgical trials – Science-Based Medicine (free) (via @gorskon)

 

6 – Viewpoint: Advance Directives for Dementia: Meeting a Unique Challenge – JAMA (free)

 

7 – Richard Lehman’s journal reviews, 6 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Last Month in Oncology with Dr. Bishal Gyawali: October 2017 – eCancer News (free)

 

9 – Association of Warfarin Use With Lower Overall Cancer Incidence Among Patients Older Than 50 Years – JAMA Internal Medicine (free)

“In this population-based cohort study of 1.256.725 persons, there was a significantly lower age- and sex-adjusted incidence rate ratio of cancer among warfarin users vs nonusers”.

 

10 – The Value of Preoperative Assessment Before Noncardiac Surgery in the Era of Value-Based Care – Circulation (free)

Related guidelines: 2014 ACC/AHA Guideline on Perioperative Cardiovascular Evaluation and Management of Patients Undergoing Noncardiac Surgery (free) AND 2014 ESC/ESA Guidelines on non-cardiac surgery: cardiovascular assessment and management (free) AND Routine preoperative tests for elective surgery – NICE Guideline (free) AND Canadian Cardiovascular Society Guidelines on Perioperative Cardiac Risk Assessment and Management for Patients Who Undergo Noncardiac Surgery (free) AND 3rd Guideline for Perioperative Cardiovascular Evaluation of the Brazilian Society of Cardiology (free)

 


 

1 – European Guidelines for treatment of HIV-positive adults – European AIDS Clinical Society (free)

Commentary: New EACS treatment guidelines – Aidsmap (free) AND EACS updates HIV guidelines for adults – Healio (free registration required)

 

2 – Effect of Sertraline on Depressive Symptoms in Patients With Chronic Kidney Disease Without Dialysis Dependence: The CAST Randomized Clinical Trial – JAMA (free)

Editorial: Treating Depression in Patients With Advanced CKD: Beyond the Generalizability Frontier (free)

Commentary: Standard Antidepressant May Not Help Patients with Chronic Kidney Disease – UT Southwestern Medical Center, via NewsWise (free)

“Not only doesn’t help treat moderate depression, sertraline causes worse nausea (NNH=8) & diarrhea (NNH=10)” (RT @AnilMakam see Tweet 1 and Tweet 2)

 

3 – Working with influenza-like illness: Presenteeism among US health care personnel during the 2014-2015 influenza season – American Journal of Infection Control (free)

Commentaries: 4 in 10 healthcare professionals work when they’re sick, risking patients – HealthCare Finance (free) AND Four in 10 Healthcare Personnel Work While Sick – Medscape (free registration required) AND Four in 10 HCPs Work While Experiencing Flu-Like Illness, Says Survey – MPR (free)

 

4 – Cardiovascular, respiratory, and related disorders: key messages from Disease Control Priorities, 3rd edition – The Lancet (free registration required)

 

5 – Testing for chronic hepatitis B and C: a global perspective – BMC Infectious Diseases (free)

 

6 – Frequent sugar-sweetened beverage consumption and the onset of cardiometabolic diseases: cause for concern? – Journal of the Endocrine Society (free)

Commentaries: Just two sugary drinks per week may raise type 2 diabetes risk – Medical News Today (free) AND Sugar-sweetened drinks raise risk of diabetes, metabolic syndrome – The Endocrine Society, via EurekAlert (free)

 

7 – Choosing Wisely: Twenty Things Physicians and Patients Should Question – American Society for Clinical Pathology (free)

Commentary: More Lab Tests Deemed Inappropriate – Medscape (free registration required)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

 

8 – What We Know About Tuberculosis Transmission: An Overview – The Journal of Infectious Diseases (free) (RT @greg_folkers see Tweet)

 

9 – Fiber Intake and Survival After Colorectal Cancer Diagnosis – JAMA Oncology (free)

Commentaries: Is Eating Fiber After Colorectal Cancer Diagnosis Associated with Lower Death Risk? – The JAMA Network (free) AND Higher Fiber Intake After Colorectal Cancer Diagnosis Tied to Improved Survival – Physician’s First Watch (free)

 

10 – Glucocorticosteroids for people with alcoholic hepatitis – Cochrane Library (free)

Original article: Glucocorticosteroids for people with alcoholic hepatitis – Cochrane Library (link to abstract – $ for full-text)

“We found no evidence of a difference between glucocorticosteroids and placebo or no intervention on all-cause mortality, health-related quality of life, and serious adverse events during treatment”.

 


 

1 – Percutaneous coronary intervention in stable angina (ORBITA): a double-blind, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Small Trial Raises Big Concerns That PCI In Stable Angina Is Just A Placebo – Cardiobrief (free) AND Diving Deep Into The ORBITA Trial – Cardiobrief (free) AND Unbelievable’: Heart Stents Fail to Ease Chest Pain – The New York Times (10 articles per month are free) AND ORBITA: PCI Offers No Symptom Improvement Over Sham Procedure – TCTMD (free)

 

2 – Balanced Crystalloids vs Saline for Critically Ill Adults – American College of Chest Physicians Annual Meeting (free abstract)

Related Study: Balanced Crystalloids vs Saline for Noncritically Ill Adults in the Emergency Department – American College of Chest Physicians Annual Meeting (free abstract)

Commentaries: Landmark Trials Deliver Evidence to Rethink Saline Use – Medscape (free registration required) AND Saline on the Ropes? Studies find balanced crystalloid fluids safer – MedPage Today (free registration required)

 

3 – Familial hypercholesterolaemia: identification and management – NICE Guideline (free)

News release: Inherited risk of high cholesterol should be identified and treated as early as possible, NICE says in updated guidance (free)

 

4 – Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association/American Stroke Association (free PDF)

Commentary: Intracranial Hemorrhage After Stroke Thrombolysis: More Questions Than Answers (free)

Top Ten Things to Know: Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in Acute Ischemic Stroke (free PDF)

Slide Set: Treatment and Outcome of Hemorrhagic Transformation After Intravenous Alteplase in AIS (free PDF)

Related AHA/ASA Guidelines: Guidelines for the Early Management of Patients With Acute Ischemic Stroke (free) AND Guidelines for the Management of Spontaneous Intracerebral Hemorrhage (free)

 

5 – Cancer incidence and mortality among young adults aged 20–39 years worldwide in 2012: a population-based study – The Lancet Oncology (free)

Commentaries: Reducing the global cancer burden among young adults – The Lancet Oncology (free) AND Global burden of cancer among young adults aged 20–39 years – eCancer News (free) AND Cancer in Young Adults Disproportionately Affects Women – Medical Research (free)

 

6 – A ‘smart’ approach to performance drugs – ACP Internist (free)

Related: Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)

 

6 – Seeing is Believing: Using Visual Abstracts to Disseminate Scientific Research – The American Journal of Gastroenterology (free)

 

7 – Opinion: Drug company sales reps should be banned from hospitals – STAT (free)

 

8 – Australia ends insurance subsidies for naturopathy, homeopathy, and more – Science-Based Medicine (free)

 

9 – Untreatable Gonorrhea Is Rapidly Spreading. Here’s What You Need to Know – TIME Health (free)

 

10 – Adolescent Childbirth Is Associated With Greater Framingham Risk Scores for Cardiovascular Disease Among Participants of the IMIAS (International Mobility in Aging Study) – Journal of The American Heart Association (free)

News release: Teen childbirth linked to increased risk for heart disease (free)

Commentaries: Teen childbirth linked to increased cardiovascular risk decades later – Cardiovascular Business (free) AND Study finds link between increased cardiovascular diseases and teen childbirth – News Medical (free)

 


 

1 – The diagnosis and management of nonalcoholic fatty liver disease: Practice guidance from the American Association for the Study of Liver Diseases – Hepatology (free)

 

2 – The Care of Children With Congenital Heart Disease in Their Primary Medical Home – Pediatrics (free)

 

3 – Glaucoma: diagnosis and management – NICE Guideline (free)

News release: People at a low risk of developing glaucoma can avoid unnecessary referral, says NICE (free)

 

4 – Overdiagnosis and disease labels: the case of polycystic ovary syndrome – STAT (free)

Related: Are expanding disease definitions unnecessarily labelling women with polycystic ovary syndrome? – The BMJ (link to summary – $ for full-text)

 

5 – Bacteria Can Evolve Resistance to Drugs Before Those Drugs Are Used – The Atlantic (free)

 

6 – What I’ve learned from 547 doctor suicides – Pamela Wible, via KevinMd.com (free)

 

7 – Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams – ACP Hospitalist (free)

Original article: Prolonged versus short-term intravenous infusion of antipseudomonal β-lactams for patients with sepsis: a systematic review and meta-analysis of randomised trials – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

8 – Updated WHO recommendation on intravenous tranexamic acid for the treatment of post-partum haemorrhage – The Lancet Global Health (free)

 

9 – Aspirin reduces a woman’s chance of developing pre-eclampsia in pregnancy – NIHR Signal (free)

Original article: Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia – New England Journal of Medicine (link to abstract – $ for full-text)

 

10 – Vaginal cleansing before caesarean delivery reduces risk of infections – NIHR signal (free)

Original article: Vaginal Cleansing Before Cesarean Delivery: A Systematic Review and Meta-analysis – Obstetrics & Gynecology (link to abstract – $ for full-text)

 


 

1 – Lancet Countdown: Traking Progress on Health and Climate Change (free infographics, video and other resources)

Report: The Lancet Countdown on health and climate change: from 25 years of inaction to a global transformation for public health (free registration required)

Commentaries: Health impacts of climate change already felt today – Imperial College London (free) AND How Climate Change Is Already Affecting Health, Spreading Disease – NPR Goats and Soda (free) AND Climate change already bringing disease, air pollution and heatwaves – The Guardian (free) AND Climate change isn’t just hurting the planet – it’s a public health emergency – The Guardian (free)

 

2 – Long-term proton pump inhibitors and risk of gastric cancer development after treatment for Helicobacter pylori: a population-based study – Gut (link to abstract – $ for full-text)

Commentaries: Acid reflux drug linked to more than doubled risk of stomach cancer – study – The Guardian (free) AND Gastric Cancer Risk Doubled With Long-term PPI Use – Medscape (free registration required) AND PPI Use After H. pylori Eradication Therapy Tied to Increased Risk for Gastric Cancer – Physician’s First Watch (free)

 

3 – Maintenance therapy with proton pump inhibitors and risk of gastric cancer: a nationwide population-based cohort study in Sweden – BMJ Open (free)

“Among 797 067 individuals on maintenance PPI therapy, the SIR of gastric cancer was over threefold increased (SIR=3.38, 95% CI 3.23 to 3.53)”.

 

4 – Review: Point of Care Ultrasound: An Overview – American College of Cardiology, Latest in Cardiology (free)

Related reviews: Ultrasonography in the emergency department – Critical Care (free) AND Clinically integrated multi-organ point-of-care ultrasound for undifferentiated respiratory difficulty, chest pain, or shock: a critical analytic review – Journal of Intensive Care (free) AND Common pitfalls in point-of-care ultrasound: a practical guide for emergency and critical care physicians – Critical Ultrasound Journal (free) AND Point-of-Care Ultrasonography by Pediatric Emergency Medicine Physicians – Pediatrics (free)

 

5 – 25th UEG (United European Gastroenterology) Week: Long-term aspirin use reduces the incidence of digestive cancers by up to 47% (free)

Commentaries: Long-Term Aspirin Use May Reduce Cancer Risk, Study Finds – Forbes (free) AND Aspirin slashes risk of gastrointestinal cancer – Medical News Today (free)

 

6 – Joint statement for the diagnosis, management, and prevention of chronic obstructive pulmonary disease for Gulf Cooperation Council countries and Middle East–North Africa region, 2017 – International Journal of Chronic Obstructive Pulmonary Disease (free)

 

7 – Mefloquine for preventing malaria during travel to endemic areas – Cochrane Library (free)

News release: Can mefloquine prevent malaria during travel to areas where the disease is widespread? (free)

Commentary: Cochrane review provides clarity about safety of mefloquine for preventing malaria in travelers – News Medical (free)

 

8 – Enjoyment of Spicy Flavor Enhances Central Salty-Taste Perception and Reduces Salt Intake and Blood Pressure – Hypertension (free)

Commentary: Can spicy foods curb salt cravings or lower blood pressure? – Reuters (free) AND Need to cut down on salt? Try something spicy instead – Medical News Today (free)

 

9 – Economic impact of palliative care among elderly cancer patients – presented at: 2017 Palliative and Supportive Care in Oncology Symposium (free abstract)

Commentaries: Palliative Care Associated With Decreased Costs For Patients With Advanced Cancer – Oncology Nurse Advisor (free) AND Early Palliative Care Is Key Driver in Reducing Costs – Medscape (free registration required)

Related study: Effect of Palliative Care on Aggressiveness of End-of-Life Care Among Patients With Advanced Cancer – Journal of Oncology Practice (link to abstract – $ for full-text) AND Commentaries: Palliative Care May Substantially Decrease Health-Care Utilization in Patients With Advanced Cancer – ASCO Post (free) AND End-of-Life Palliative Care Lowered Utilization for Patients With Cancer – AJMC (free)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

10 – Classification of Cough as a Symptom in Adults and Management Algorithms: CHEST Guideline and Expert Panel Report (free PDF)

See also other recent CHEST guidelines on the management of cough in specific populations: Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold – CHEST Expert Panel Report (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough: CHEST Guideline and Expert Panel Report (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis: CHEST Guideline and Expert Panel Report (free)

 

 


 

1 – Global tuberculosis report 2017 – World Health Organization (free PDF)

News release: WHO report signals urgent need for greater political commitment to end tuberculosis (free)

Commentaries: Tuberculosis world’s top infectious killer; UN health agency calls for political action to stop spread – UN News Center (free) AND Pandemic alert: Tuberculosis is world’s No. 1 infectious killer – CNBC (free) Despite progress, WHO paints ‘grim’ picture of global TB – CIDRAP (free)

 

2 – 2017 AHA/ACC/HRS Guideline for Management of Patients with Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death (free PDF)

News release: Societies Detail Treatment for Patients With Ventricular Arrhythmias (free)

See also: Executive summary (free PDF) AND Top Ten Things to Know (free PDF) AND Slide Set (free PDF)

 

3 – PCI Strategies in Patients with Acute Myocardial Infarction and Cardiogenic Shock – New England Journal of Medicine (free)

Editorial: Back to the Future in Cardiogenic Shock — Initial PCI of the Culprit Lesion Only (free)

Commentaries: CULPRIT-SHOCK Disputes Benefit of Immediate Multivessel PCI in Patients With Cardiogenic Shock – TCTMD (free) AND CULPRIT-SHOCK: Culprit Lesion Only PCI Vs. Immediate Multivessel PCI in Cardiogenic Shock – American College of Cardiology, Latest in Cardiology (free)

 

4 – Prenatal Exposure to Acetaminophen and Risk of ADHD – Pediatrics (free)

Commentaries: An Association Between Prenatal Acetaminophen Use and ADHD: The Benefits of Large Data Sets – Pediatrics (free) AND Long-term Acetaminophen Use in Pregnancy and ADHD – 2 Minute Medicine (free) AND Study links acetaminophen in pregnancy to ADHD, but experts question results – CNN (free)

 

5 – Policy Statement: Cord Blood Banking for Potential Future Transplantation – American Academy of Pediatrics (free)

News release: Updated policy reaffirms value of public over private cord blood banks (free)

Commentaries: Pediatrics Group Updates Recommendations on Cord Blood Banking – Physician’s First Watch (free)

 

6 – Duration of Breastfeeding and Risk of SIDS: An Individual Participant Data Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentary: Breastfeeding for two months halves risk of SIDS – University of Virginia Health System, via ScienceDaily (free)

 

7 – Is there a conflict of interest behind your cancer diagnosis? – STAT (free)

 

8 – Richard Lehman’s journal reviews, 30 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Electronic cigarette use and smoking initiation among youth: a longitudinal cohort study – Canadian Medical Association Journal (free)

Commentary: E-cigarette use by high school students linked to cigarette smoking – ScienceDaily (free)

 

10 – Review: So you think it is sepsis: considerations beyond lung and urine in the sick patient without a source – emDocs (free)

 


 

1 – Book: Injury Prevention and Environmental Health – Disease Control Priorities, Third Edition (free)

Press Release: Disease Control Priorities, 3rd Edition Launches Volume on Injury Prevention & Environmental Health (free)

Previous volumes: 1 – Essential Surgery / 2 – Reproductive, Maternal, Newborn, and Child Health / 3 – Cancer / 4 – Mental, Neurological, and Substance Use Disorders

 

2 – NICE Guideline: Sinusitis (acute): antimicrobial prescribing (free)

News release: Antibiotics should not be used to treat the majority of sinus infections, NICE says (free)

 

3 – NICE Guideline: Cystic fibrosis: diagnosis and management (free)

News release: People with cystic fibrosis could be monitored through phone or video messaging, says NICE (free)

 

4 – NICE Guideline: Cataracts in adults: management (free)

News release: Take a patient-centred approach to treating cataracts, says NICE (free)

 

5 – KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors – Transplantation (free)

See also: Summary of KDIGO Clinical Practice Guideline on the Evaluation and Care of Living Kidney Donors (free)

News release: KDIGO Guidelines on Living Kidney Donors: A Call for A Paradigm Shift (free)

 

6 – Influence of pharmaceutical marketing on Medicare prescriptions in the District of Columbia – PLOS One (free)

Commentaries: The More Lavish the Gifts to Doctors, the Costlier the Drugs They Prescribe – The New York Times (10 articles per month are free) AND Study finds even small gifts from pharma companies change prescribing habits – FierceHealthcare (free) AND Pharma gifts to providers result in more branded, expensive prescriptions – Georgetown University Medical Center, via EurekAlert (free)

 

7 – Why we need better evidence – Centre for Evidence-Based Medicine, University of Oxford (free)

“20 fundamental problems with the production of evidence” (RT @CochraneUK see Tweet)

 

8 – Viewpoint: The Evolution of Patient Diagnosis: From Art to Digital Data-Driven Science – JAMA (free)

 

9 – Review: Acute Management of Pulmonary Embolism – American College of Cardiology, Latest in Cardiology (free)

 

10 – Daytime variation of perioperative myocardial injury in cardiac surgery and its prevention by Rev-Erbα antagonism: a single-centre propensity-matched cohort study and a randomised study – The Lancet (link to abstract – $ for full-text)

Commentaries: Why Heart Surgery May be Better in the Afternoon – Scientific American (free) AND Afternoon heart surgery has lower risk of complications, study suggests – The Guardian (free) AND Aortic Valve Replacement: Afternoon Surgery Linked to Fewer Adverse Events – Physician’s First Watch (free)

 


 

1 – Screening for Lung Cancer: CHEST Guideline and Expert Panel Report – American College of Chest Physicians (free)

News release: American College of Chest Physicians unveils new lung cancer screening guidelines at CHEST 2017 (free)

 

2 – Guideline: Responding to children and adolescents who have been sexually abused – World Health Organization (free)

News release: Responding to children and adolescents who have been sexually abused (free)

 

3 – Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study – The BMJ (free)

“Industry payments to journal editors are common and often large, particularly for certain subspecialties. Journals should consider the potential impact of such payments on public trust in published research”.

 

4 – Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis – The BMJ (free)

“Women with antithrombin, protein C, or protein S deficiency or with homozygous factor V Leiden should be considered for antepartum or postpartum thrombosis prophylaxis, or both”.

 

5 – Regular antibiotics for preventing pneumococcal infection in young children with sickle cell disease – Cochrane Library (free)

Original article: Prophylactic antibiotics for preventing pneumococcal infection in children with sickle cell disease – Cochrane Library (link to abstract – $ for full-text)

Source: EvidenceAlerts

 

6 – World leaders rehearse for a pandemic that will come ‘sooner than we expect’ – The Washington Post (free)

 

7 – Perspective: HIV Drug Resistance: An Emerging Threat to Epidemic Control – New England Journal of Medicine (free)

 

8 – Terbinafine is probably first choice oral drug for fungal toenail infection – NIHR Signal (free)

Original article: Oral antifungal medication for toenail onychomycosis – Cochrane Library (free)

 

9 – Clinical guidelines for the prevention and treatment of osteoporosis: summary statements and recommendations from the Italian Society for Orthopaedics and Traumatology – Journal of Orthopaedics and Traumatology (free)

 

10 – Austrian consensus guidelines on the management and treatment of portal hypertension (Billroth III) – Wiener klinische Wochenschrift (free)

 


 

1 – Modifiers of the effect of maternal multiple micronutrient supplementation on stillbirth, birth outcomes, and infant mortality: a meta-analysis of individual patient data from 17 randomised trials in low-income and middle-income countries – The Lancet Global Health (free)

Commentaries: Antenatal multiple micronutrient supplementation: benefits beyond iron-folic acid alone – The Lancet Global Health (free) AND Multiple micronutrient supplements to mothers improve survival for newborn girls – Harvard School of Public health (free)

Related systematic review: Multiple-micronutrient supplementation for women during pregnancy – Cochrane Library (free summary)

 

2 – Less dementia with oral anticoagulation in atrial fibrillation – European Heart Journal (free)

Commentaries: Blood-thinning drugs appear to protect against dementia in AF patients – OnMedica (free) AND Blood-thinning drugs ‘can reduce risk of dementia by up to 48%’ – The Guardian (free) AND Oral Anticoagulants Tied to Less Dementia in Patients with Atrial Fibrillation – Physician’s First Watch (free)

 

3 – Surgery for Drug-Resistant Epilepsy in Children – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: First test of anti-epilepsy surgeries in children shows dramatic benefit – Reuters (free) AND Surgery Cuts Seizures in Drug-Resistant Epilepsy – MedPage Today (free registration required)

 

4 – Guideline: Long-Acting Reversible Contraception: Implants and Intrauterine Devices – American College of Obstetricians and Gynecologists (free)

News release: LARC and Reproductive Choice (free)

Commentary: New Guidelines on LARC Released by ACOG – Medscape (free registration required)

 

5 – Review: The Practice and Implications of Finding Fluid During Point-of-Care Ultrasonography – JAMA Internal Medicine (free)

Related JAMA Video: Finding Fluid With Point-of-Care Ultrasonography (free)

 

6 – Depression and mortality in a longitudinal study: 1952–2011 – Canadian Medical Association Journal (free)

Commentaries: Depression strongly linked to higher long-term risk of early death for both women, men – ScienceDaily (free) AND Depression raises risk of early death – Medical News Today (free) AND Depression tied to shorter lifespan – Reuters (free)

 

7 – Is It Possible to Predict the Next Pandemic? – The Atlantic (free)

“Large initiatives are underway to pinpoint the next big viral threats—but some virologists believe the task is too hard”.

 

8 – Prognostic Effect and Longitudinal Hemodynamic Assessment of Borderline Pulmonary Hypertension – JAMA Internal Medicine (free)

Commentary: Borderline Pulmonary Hypertension Tied to Mortality Risk – MedPage Today (free registration required)

 

9 – Here’s Why Vaccines Are So Crucial – National Geographic Magazine (free) (via @filiamd)

 

10 – Aerosol delivery during invasive mechanical ventilation: a systematic review – Critical Care (free)

 


 

1 – Statin use and risk of developing diabetes: results from the Diabetes Prevention Program – BMJ Open Diabetes Research & Care (free)

Commentaries: Statins increase the risk of developing diabetes in at-risk people – Medical News Today (free) AND Statin use link to heightened type 2 diabetes risk in some people – OnMedica (free)

 

2 – Synopsis of the 2017 U.S. Department of Veterans Affairs/U.S. Department of Defense Clinical Practice Guideline: Management of Type 2 Diabetes Mellitus – Annals of Internal Medicine (free)

Related 2017 Guidelines: Type 2 diabetes in adults: management – NICE Guideline (free) AND Pharmacologic Therapy for Type 2 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes (free) AND Oral Pharmacologic Treatment of Type 2 Diabetes Mellitus: A Clinical Practice Guideline Update From the American College of Physicians (free)

 

3 – Global prevalence of injecting drug use and sociodemographic characteristics and prevalence of HIV, HBV, and HCV in people who inject drugs: a multistage systematic review – The Lancet Global Health (free)

Related article: Global, regional, and country-level coverage of interventions to prevent and manage HIV and hepatitis C among people who inject drugs: a systematic review – The Lancet Global Health (free)

Commentary: New research highlights worldwide risk of HIV, Hepatitis C epidemics – University of New South Wales, via ScienceDaily (free)

 

4 – Effect of Robotic-Assisted vs Conventional Laparoscopic Surgery on Risk of Conversion to Open Laparotomy Among Patients Undergoing Resection for Rectal Cancer: The ROLARR Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Related Study: Association of Robotic-Assisted vs Laparoscopic Radical Nephrectomy With Perioperative Outcomes and Health Care Costs, 2003 to 2015 – JAMA (free)

Commentaries: Comparison of Outcomes for Robotic-Assisted vs Laparoscopic Surgical Procedures – The JAMA Network (free) AND Robotic docs can boost surgery time and cost – Science News (free) AND Robot-assisted surgery for kidney removal associated with longer operating times, higher cost – Stanford Medicine (free) AND Robotic-assisted surgery: more expensive, but not always more effective – Reuters (free)

 

5 – Psilocybin for treatment-resistant depression: fMRI-measured brain mechanisms – Scientific Reports (free)

Recommended Commentary: Magic mushrooms: Some reporters buy magical notion of ‘reset’ button for depression – Health News Review (free)

Other Commentaries: Magic mushrooms ‘reboot’ brain in depressed people – study – The Guardian (free) AND Magic mushrooms can ‘reset’ depressed brain – BBC News (free)

 

6 – Cardiovascular Health in African Americans: A Scientific Statement From the American Heart Association – Circulation (free PDF)

News releases: African Americans live shorter lives due to heart disease and stroke – AHA / ASA Newsroom (free) AND New report raises concerns about the cardiovascular health of African-Americans – AHA News (free)

Commentaries: Blacks Face Higher Mortality from Heart Disease, Stroke – Cardiobrief (free) AND Heart health disparities take toll on African-Americans – Reuters (free)

 

7 – A baby with a disease gene or no baby at all: Genetic testing of embryos creates an ethical morass – STAT (free)

 

8 – Richard Lehman’s journal review, 23 October 2017 – The BMJ Opinion (free)

Richard Lehman’s weekly review of medical journals.

 

9 – Protection of the house against Chagas disease, dengue, leishmaniasis, and lymphatic filariasis: a systematic review – The Lancet Infectious Diseases (free registration required)

 

10 – Head position after acute stroke does not affect disability outcomes – NIHR Signal (free)

Original article: Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke – The New England Journal of Medicine (link to abstract – $ for full-text)

 


 

1 – Guideline: Hepatitis B (chronic): diagnosis and management – National Institute for Health and Care Excellence (free)

 

2 – British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD) – Thorax (free)

 

3 – A toolkit for reducing repetitive routine blood draws in hospitals – Choosing Wisely Canada (free PDF)

News release: Toolkit: Pause the Draws (free)

 

4 – Policy Statement: Infection Prevention and Control in Pediatric Ambulatory Settings – American Academy of Pediatrics (free)

News release: Updated policy offers guidance on infection prevention, control in ambulatory settings (free)

Commentaries: Pediatrician’s New Germ-Control Advice: Bring Your Own Toys (10 articles per month are free) AND AAP: Hygiene, isolation protocols critical for infection control in pediatric office – Healio (free registration required)

 

5 – Clinical Report: Sexual and Reproductive Health Care Services in the Pediatric Setting – American Academy of Pediatrics (free)

News release: Pediatricians have key role in providing sexual, reproductive health care services (free)

 

6 – Incidence, Demographics, and Clinical Characteristics of Diabetes of the Exocrine Pancreas (Type 3c): A Retrospective Cohort Study – Diabetes Care (link to abstract – $ for full-text)

Commentary: Newly-identified third type of diabetes is being wrongly diagnosed as type 2 – The Conversation (free)

“Diabetes of the exocrine pancreas is frequently labeled type 2 diabetes but has worse glycemic control and a markedly greater requirement for insulin”.

 

7 – Concussion in adolescence and risk of multiple sclerosis – Annals of Neurology (link to abstract – $ for full-text)

Commentaries: Concussions in Teenagers Tied to Multiple Sclerosis Risk – The New York Times (10 articles per month are free) AND Teenage concussion linked to later risk of MS – Medical News Today (free)

 

8 – Multidisciplinary consensus on screening for, diagnosis and management of fetal growth restriction in the Netherlands – BMC Pregnancy and Childbirth (free)

 

9 – Clinical Management of Insomnia Disorder – JAMA (free)

“Cognitive Behavior Therapy for insomnia is recommended as 1st-line Tx; pharmacotherapy, if used, should be on a short-term basis” (RT @JAMAInternalMed see Tweet)

 

10 – Review: The challenge of Takotsubo syndrome: heterogeneity of clinical features – Swiss Medical Weekly (free)

 


 

1 – Global causes of blindness and distance vision impairment 1990–2020: a systematic review and meta-analysis – The Lancet Global Health (free)

Invited commentary: Global causes of vision loss in 2015: are we on track to achieve the Vision 2020 target? (free)

Related study: Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis – The Lancet Global Health (free) AND Invited Commentary: Universal eye health: are we getting closer? (free)

 

2 – Upright versus lying down position in second stage of labour in nulliparous women with low dose epidural: BUMPES randomised controlled trial – The BMJ (free)

Commentaries: During Labor, Lie Down – The New York Times (10 articles per month are free) AND Normal birth more likely when lying down in late stages, post epidural – OnMedica (free)

 

3 – Summary with 10 key points to remember: Thrombophilia Testing and Venous Thrombosis – American College of Cardiology, Latest in Cardiology (free)

See also: Thrombophilia Testing and Venous Thrombosis – NEJM Resident 360 (free)

Original article: Thrombophilia Testing and Venous Thrombosis – New England Journal of Medicine (link to abstract – $ for full-text)

 

4 – Is gene editing ethical? – Medical News Today (free)

Related: Embryo Gene-Editing Experiment Reignites Ethical Debate – Scientific American (free) AND U.S. scientists edit genome of human embryo, but cast doubt on possibility of ‘designer babies’ – STAT (free)

Related Position Statement: Human Germline Genome Editing – American Society of Human Genetics (free) AND Commentary: 11 Organizations Urge Cautious but Proactive Approach to Gene Editing (free)

 

5 – Trial Evaluating Ambulatory Therapy of Travelers’ Diarrhea (TrEAT TD) Study: A Randomized Controlled Trial Comparing 3 Single-Dose Antibiotic Regimens With Loperamide – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentary: Azithromycin, levofloxacin, rifaximin all effective for travelers diarrhea – Healio (free registration required)

 

6 – Literature review: the economic costs of lung disease and the cost effectiveness of policy and service interventions – British Lung Foundation and British Thoracic Society (free PDF)

News release: New report identifies the most cost effective NHS activities and programmes to improve lung health – British Thoracic Society (free)

Source: Most cost effective treatments for lung disease identified – The BMJ News ($)

“The most cost effective treatments are: patient education and self management for asthma; stop smoking support for chronic obstructive pulmonary disease (COPD); vaccination programmes for pneumonia; and awareness campaigns for lung cancer” (from The BMJ).

 

7 – Walking in Relation to Mortality in a Large Prospective Cohort of Older U.S. Adults – American Journal of Preventive Medicine (free)

Commentaries: Regular Walking, Even if Minimal, Tied to Lower Death Risk – Medscape (free registration required) AND Study finds even regular walking can lower mortality risk – UPI (free)

 

8 – Weight Gain in Women at Midlife: A Concise Review of the Pathophysiology and Strategies for Management – Mayo Clinic Proceedings (free)

Commentary: Docs Call Attention to Women Piling on Pounds in Midlife – Medscape (free registration required)

 

9 – Carefully managed antibiotic use could halve antibiotic-resistant infections – NIHR Signal (free)

Original article: Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis – The Lancet Infectious Diseases (link to abstract – $ for full-text)

 

10 – Placing wet gauze on babies’ tummies speeds up urine collection – NIHR Signal (free)

Original article: Faster clean catch urine collection (Quick-Wee method) from infants: randomised controlled trial – The BMJ (free)

 


 

1 – Levels & Trends in Child Mortality – UNICEF (free PDF)

News release: Levels and Trends in Child Mortality (free)

Commentaries: 7,000 newborns die every day, despite steady decrease in under-five mortality, new report says – The World Bank (free) AND New child mortality estimates show that 15,000 children died every day in 2016 – The World Bank (free) AND Unconscionable': 7,000 babies die daily despite record low for child mortality – The Guardian (free)

 

2 – Report: The Lancet Commission on pollution and health (Report, Executive Summary, Video, Audio and Comments – free registration required)

Commentaries: Report: Pollution Kills 3 Times More than AIDS, TB And Malaria Combined – NPR (free) AND Pollution linked to one in six deaths – BBC (free)

 

3 – 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea (free)

Commentary: New diarrhea guidelines stress implications of molecular tests – CIDRAP (free)

 

4 – Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology (free)

 

5 – Elevated blood pressure and risk of mitral regurgitation: A longitudinal cohort study of 5.5 million United Kingdom adults – PLOS Medicine (free)

Commentaries: High Blood Pressure Is a Risk Factor For Mitral Regurgitation – Medical Research (free) AND High Blood Pressure May Raise Mitral Regurgitation Risk – TCTMD (free) AND Inevitable or preventable? High blood pressure linked to mitral regurgitation – Cardiovascular Business (free)

 

6 – High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis – Systematic Reviews (free)

“In patients with acute hypoxemic respiratory failure HFNC was not associated with a difference in mortality compared to Noninvasive ventilation or standard oxygen”

 

7 – Imaging Studies Offer New Insights Into Inflammation In CV Disease – Cardiobrief (free)

Original article: Colchicine Therapy and Plaque Stabilization in Patients With Acute Coronary Syndrome – Journal of The American College of Cardiology (link to abstract – $ for full-text)

“Preliminary evidence that colchicine may reduce coronary plaque”.

 

8 – Evidence-based guidelines for supportive care of patients with Ebola virus disease – The Lancet (free)

Commentaries: New Ebola guidelines address immediate supportive care – CIDRAP (free)

 

9 – Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection – MMWR / CDC (free)

Commentaries: CDC Offers New Guidance on Diagnosing and Managing Zika in Infants – Physician’s First Watch (free)

 

10 – A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets – Cell Host Microbe (free)

Commentaries: H7N9 study finds virus poised to become more lethal, resistant to treatment – CIDRAP (free) AND H7N9 influenza is both lethal and transmissible in animal model for flu – University of Wisconsin–Madison (free) AND Will the World’s Most Worrying Flu Virus Go Pandemic? – The Atlantic (free)

 


 

1 – 2017 ACC Expert Consensus Decision Pathway on the Management of Mitral Regurgitation – Journal of The American College of Cardiology (free)

Commentaries: Expert Consensus Decision Pathway for Management of Mitral Regurgitation – American College of Cardiology, Latest in Cardiology (free) AND ACC Recommends ‘Structured Approach’ to Mitral Regurgitation – MedPage Today (free registration required)

 

2 – Update to Practice Standards for Electrocardiographic Monitoring in Hospital Settings: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentaries: 12 key points to remember: Standards for Inpatient Electrocardiographic Monitoring – American College of Cardiology, Latest in Cardiology (free) AND AHA updates practice standards for electrocardiographic monitoring – ACP Hospitalist (free)

 

3 – Dark chocolate is now a health food. Here’s how that happened – VOX (free)

Related: Chocolate health: advice by Thomas Lüscher and peer review by Jonas Malmstedt – For Better Science (by @schneiderleonid)

“Big Chocolate’s investment in health science was a marketing masterstroke…” Interesting tale by @juliaoftoronto (RT @hildabast see Tweet)

 

4 – Long-term antibiotics likely to reduce risk of recurrent cellulitis – NIHR Signal (free)

Original article: Interventions for the prevention of recurrent erysipelas and cellulitis – Cochrane Library (link to abstract – $ for full-text)

 

5 – Comparing the Outcomes of Adults With Enterobacteriaceae Bacteremia Receiving Short-Course Versus Prolonged-Course Antibiotic Therapy in a Multicenter, Propensity Score–Matched Cohort – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentary: Short course of antibiotics worked as well as long for Enterobacteriaceae bacteremia – ACP Hospitalist (free)

 

6 – Report: Opportunities for Organ Donor Intervention Research: Saving Lives by Improving the Quality and Quantity of Organs for Transplantation (2017) – National Academies Press (free PDF)

Related Viewpoint: Organ Donor Research: Overcoming Challenges, Increasing Opportunities – JAMA (free)

 

7 – Short and Long Term Complications of In Utero Exposure to Lamotrigine – British Journal of Clinical Pharmacology (free PDF)

News release: Study Finds Epilepsy Drug to Be Safe During Pregnancy – Wiley (free)

Source: Study finds lamotrigine to be safe during pregnancy – The BMJ Research News ($)

 

8 – Richard Lehman’s journal review, 17 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Association of Patient Frailty With Increased Morbidity After Common Ambulatory General Surgery Operations – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Frailty Associated With Increased Risk of Complications Following Common, Outpatient Operations – The JAMA Network (free) AND Frailty tied to higher risk of complications with common surgeries – Reuters (free) AND Frailty linked to higher rate of perioperative morbidity – OnMedica (free)

 

10 – 25-Year Physical Activity Trajectories and Development of Subclinical Coronary Artery Disease as Measured by Coronary Artery Calcium – Mayo Clinic Proceedings (free)

Commentaries: Excessive Exercise May Harm The Heart, Study Suggests – Forbes (free) AND Physically active white men at high risk for plaque buildup in arteries – ScienceDaily (free)

 


 

1 – Guideline: 2017 Appropriate Use Criteria for the Treatment of Patients With Severe Aortic Stenosis (free)

Commentaries: 2017 AUC for Management of Severe Aortic Stenosis – American College of Cardiology, Latest in Cardiology (free) AND First Appropriate Use Criteria Issued for Severe Aortic Stenosis – Medpage Today (free registration required)

 

2 – Association of Blood Transfusion From Female Donors With and Without a History of Pregnancy With Mortality Among Male and Female Transfusion Recipients – JAMA (link to abstract – $ for full-text)

Commentaries: Blood Boundaries: Should Transfusions Be Matched by Sex? – Scientific American (free) AND Are transfusions harmful to men if the blood comes from women who have been pregnant? – STAT (free) AND Receipt of Blood Transfusion From Previously Pregnant Donor Associated with Increased Risk of Death Among Male Recipients – The JAMA Network (free)

 

3 – Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free)

Antibiotic-associated diarrhea ocurred in 8.0% of the probiotic group compared to 17.7% in the control group. The number needed to treat (NNT) to prevent one case of diarrhea was 11 (95% CI 6 to 13).

 

4 – Approach to recurrent fever in childhood – Canadian medical Association Journal (free)

 

5 – Comparative safety of direct oral anticoagulants and warfarin in venous thromboembolism: multicentre, population based, observational study – The BMJ (free)

Commentary: New Anticoagulants Not Linked To Excess Bleeding Rates – Cardiobrief (free)

 

6 – How Low to Go With Glucose, Cholesterol, and Blood Pressure in Primary Prevention of CVD – Journal of The American College of Cardiology (free)

Summary with 12 key points to remember: Glucose, Cholesterol, BP Targets for CVD Risk Factors – American College of Cardiology, Latest in Cardiology (free)

 

7 – Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: Omega-6 fats may help prevent type 2 diabetes – George Institute for Global Health (free) AND Eating More Nuts Could Protect Against Type 2 Diabetes – Medscape (free registration required) AND Omega-6 could lower type 2 diabetes risk by 35 percent – Medical News Today (free)

 

8 – The oncologic burden of hepatitis C virus infection: A clinical perspective – CA: A Cancer Journal for Clinicians (free)

 

9 – Recommendations for Prevention and Control of Influenza in Children, 2017 – 2018 – American Academy of Pediatrics (free)

Commentary: 2017-2018 recommendations for pediatric influenza vaccination – Clinical Advisor (free) AND Fall Weather Headed Your Way? Time For Flu Shots – NPR (free)

 

10 – Individual support of nurses using electronic medicine monitors can improve HIV treatment – NIHR Signal (free)

Original article: Effectiveness and cost-effectiveness of a nurse-delivered intervention to improve adherence to treatment for HIV: a pragmatic, multicentre, open-label, randomised clinical trial – The Lancet Infectious Diseases (free)

 


 

1 – Association of History of Gestational Diabetes With Long-term Cardiovascular Disease Risk in a Large Prospective Cohort of US Women – JAMA Internal Medicine (free)

Commentaries: CVD Risk for Women Rises After Gestational Diabetes – TCTMD (free) AND Does Gestational Diabetes Per Se Up Long-Term Cardiovascular Risk? – Medscape (free registration required) AND Gestational Diabetes Raises Heart Attack, Stroke Risk, NIH Study Finds – AJMC (free)

 

2 – Association of Antidepressant Medications With Incident Type 2 Diabetes Among Medicaid-Insured Youths – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Antidepressant Use in Youth Tied to Increased Diabetes Risk – Physician’s First Watch (free)

Related article: The risk of new-onset diabetes in antidepressant users – A systematic review and meta-analysis – PLOS One (free) AND Commentary: Type 2 Diabetes and Antidepressant Drug Use: Is There a Causal Link? – Endocrinology Advisor (free)

 

3 – State of The Art Review: Why and how to step down chronic asthma drugs – The BMJ (free)

 

4 – Clinical Use of a Home Sleep Apnea Test: An American Academy of Sleep Medicine Position Statement (free)

News release: AASM releases position statement on home sleep apnea testing (free)

Commentaries: AASM: Position Statement on Home Sleep Apnea Testing – MPR (free) AND Sleep Medicine Academy Releases Statements on Home Apnea Testing – Physician’s First Watch (free)

 

5 – Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) – Circulation (link to abstract – $ for full-text)

Commentaries: A-fib strikes men a decade earlier than women – Medical News Today (free) And AHA: Men develop AFib a decade before women do; BMI linked to increased risk – Cardiovascular Business (free)

 

6 – Modelled Cost-Effectiveness of a Package Size Cap and a Kilojoule Reduction Intervention to Reduce Energy Intake from Sugar-Sweetened Beverages in Australia – Nutrients (free)

Commentaries: Cutting sugar in soft drinks would save 155,000 lives and $8 billion: experts – The Age (free) AND Study spells out huge health benefits by cutting back sugar in sugary drinks – University of New South Wales, Sidney (free)

 

7 – We may soon have our first $1 million drug. Who will pay for it? And how? – STAT (free)

 

8 – Long-term Outcomes of Multiple Arterial Coronary Artery Bypass Grafting: A Population-Based Study of Patients in British Columbia, Canada – JAMA Cardiology (free)

Commentaries: Study: Triple-Vessel CABG Strategy Matters in the Long Run – MedPage Today (free registration required)

In patients with multivessel disease who are undergoing coronary artery bypass grafting, multiple arterial grafting (MAG) is associated with reduced mortality, repeated revascularization, myocardial infarction, and heart failure when compared with left internal thoracic artery (LITA) supplemented by saphenous vein grafts (LITA+SVG).

 

9 – 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery (free)

 

10 – Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus – Nature Communications (free)

Commentaries: Proton pump inhibitors linked to liver disease, researchers find – The Pharmaceutical Journal (free) AND Liver disease risk may be heightened by gastric acid drugs – Medical News Today (free) AND Common acid reflux medications promote chronic liver disease – EurekAlert (free)

 


 

1 – The Revised Declaration of Geneva: A Modern-Day Physician’s Pledge – JAMA (free)

 

2 – Alleviating the access abyss in palliative care and pain relief—an imperative of universal health coverage: the Lancet Commission report (free registration required)

Commentaries: A milestone for palliative care and pain relief – The Lancet (free registration required) AND Millions die suffering amid global opioid gap, report says – STAT (free) AND More than 25 million people dying in agony without morphine every year – The Guardian (free)

 

3 – Guideline: Assessing and managing children at primary health-care facilities to prevent overweight and obesity in the context of the double burden of malnutrition – World Health Organization (free) (RT @equitylist see Tweet)

News release: WHO releases guidelines to address overweight and obesity in children (free)

Related report: Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults – The Lancet (free) AND Commentaries: Tenfold increase in childhood and adolescent obesity in four decades: new study by Imperial College London and WHO – World Health Organization (free) Double-duty solutions for the double burden of malnutrition (free)

 

4 – Long Sleeves on Doctors’ White Coats May Spread Germs – Scientific American (free)

Related guideline: Healthcare Personnel Attire in Non-Operating-Room Settings – Infection Control and Hospital Epidemiology (free) AND Commentaries: Goodbye to the Doctor’s White Coat? – The New York Times (10 articles per month are free) AND New infection control recommendations could make white coats obsolete – ScienceDaily (free) AND Should Doctors Still Be Allowed to Wear White Coats? You Decide – HIV and ID Observations (free)

 

5 – Draft Recommendation Statement: Skin Cancer Prevention: Behavioral Counseling – U.S. Preventive Services Task Force (free)

Commentary: USPSTF Draft Statement Recommends Sun-Safe Behavioral Counseling for More Fair-Skinned Youth – Physician’s First Watch (free)

 

6 – Blood pressure targets in people with cardiovascular disease – Cochrane Library (free)

 

7 – Testing blood procalcitonin levels to decide when to start and stop antibiotics in adults with acute respiratory tract infections – Cochrane Library (free)

Original Article: Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections – Cochrane Library (link to abstract – $ for full-text)

“the use of procalcitonin to guide initiation and duration of antibiotic treatment results in lower risks of mortality, lower antibiotic consumption, and lower risk for antibiotic-related side effects”.

 

8 – 2017 EACTS Guidelines on perioperative medication in adult cardiac surgery – European Journal of Cardio-Thoracic Surgery (free)

Source: Critical Care Reviews Newsletter (free)

 

9 – Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging – Proceedings of the National Academy of Sciences (free)

Commentary: Rapid Test for Antibiotic Susceptibility – JAMA (free)

 

10 – Older people with acute coronary syndromes may benefit from routine invasive therapy – NIHR Signal (free)

Original article: Revascularisation compared with initial medical therapy for non-ST-elevation acute coronary syndromes in the elderly: a meta-analysis – Heart (link to abstract – $ for full-text)

 


 

1 – Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia – New England Journal of Medicine (free)

Editorial: Handle Survivors with Care (free)

Commentaries: Experimental Ebola vaccines elicit year-long immune response – NIH New Releases (free) AND Ebola Vaccines Elicit Immune Responses in Liberian Adults – Physician’s First Watch (free) AND Liberia trial finds Ebola vaccines yield year-long immune response – CIDRAP (free)

 

2 – Roadmap for zoonotic tuberculosis – Worl Health Organization (free)

WHO News release: TB partners launch first roadmap to jointly stop the transmission of bovine and zoonotic tuberculosis (free)

 

3 – Increasing prevalence of vascular risk factors in patients with stroke – Neurology (link to abstract – $ for full-text)

Commentary: Health Conditions That Increase Stroke Risk Rise Across All Ages, Races – NPR (free)

“An estimated 80% of all 1st strokes are due to risk factors that can be changed,” says new study (RT @ACCmediacenter see Tweet)

 

4 – Review: Management of cardiovascular diseases in patients with obesity – Nature Reviews Cardiology (free)

 

5 – Clinical Practice Guidelines for the Treatment of Rectal Prolapse – Diseases of the Colon & Rectum (free)

 

6 – Management of a Diabetic Foot – JAMA Clinical Guidelines Synopsis (free) (RT @adamcifu)

Original guideline: The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine (free)

 

7 – We Need to Talk About Kids and Smartphones – TIME (free)

Related: Have Smartphones Destroyed a Generation? – The Atlantic (free)

“Just how dangerous are smartphones for kids? Here’s why health experts are worried”

 

8 – Last Month in Oncology with Dr. Bishal Gyawali: September 2017 – eCancer News (free)

 

9 – Diagnostic and therapeutic treatment modalities for acute lower gastrointestinal bleeding: a systematic review – Endoscopy International Open (free)

 

10 – Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials – The Lancet Haematology (free)

Commentaries: Treatment of iron deficiency is getting trendy – The Lancet Haematology (free) AND Taking Iron Every Other Day Linked to Better Absorption in Iron-Deficient Women – Physician’s First Watch (free)

 


 

1 – The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free)

See also: Executive Summary (free)

 

2 – Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association (free)

News release: Looking beyond the heart in adults with congenital heart disease (free)

Commentary: Think Outside the Heart: Noncardiac Complications and Considerations in the Adult Congenital Patient (free)

Top Ten Things to Know: Diagnosis and Management of Noncardiac Complications in Adults with Congenital Heart Disease (free PDF)

 

3 – Social Determinants of Health 101 for Health Care: Five Plus Five – National Academy of Medicine (free)

See also: About social determinants of health – World Health Organization (free) AND WHO’s work on SDoH (free resources)

 

4 – Relative age within the school year and diagnosis of attention-deficit hyperactivity disorder: a nationwide population-based study – The Lancet Psychiatry (free)

Commentaries: The role of schools in the diagnosis of ADHD – The Lancet Psychiatry (free) AND ‘Relative’ school age biases ADHD diagnosis – OnMedica (free) AND Youngest children in school year ‘more likely’ to get ADHD diagnosis – NHS Choices (free)

 

5 – Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age – JAMA (free)

Commentaries: Ovarian reserve tests aren’t a good predictor of fertility, study finds – STAT (free) AND Tests Thought To Predict Future Fertility May Be Overused – Forbes (free) AND Fertility MOT tests ‘a waste of money’ – BBC News (free) AND Biomarkers Indicating Diminished Reserve of Eggs not Associated with Reduced Fertility – The JAMA Network (free)

 

6 – Meet the nocebo effect, the placebo effect’s evil twin that makes you feel pain – VOX (free)

 

7 – Comparison of postoperative outcomes among patients treated by male and female surgeons: a population based matched cohort study – The BMJ (free)

Editorial: Improving patient outcomes after surgery (free)

Commentaries: Female Surgeons Hold Slight Edge Over Male Peers in Terms of Patients’ 30-Day Mortality – TCTMD (free) AND Do Patients Have Better Survival with Female Surgeons? – MedPage Today (free registration required)

 

8 – Is child vaccination boosted by educating mothers? – BBC News (free)

 

9 – Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis – Journal of Neurology, Neurosurgery & Psychiatry article (link to abstract – $ for full-text)

Commentaries: Fatty diets may boost relapse risk in MS children – OnMedica (free) AND High Fat Intake Linked to Risk for MS Relapse in Kids – Physician’s First Watch (free)

 

10 – Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes – JAMA (link to abstract – $ for full-text)

Commentaries: Insulin Pumps Associated With Lower Risk of Serious Complications among Young Patients with Type 1 Diabetes – The JAMA Network (free) AND Insulin-Pump Use Benefits Young People With Type 1 Diabetes – Medscape (free registration required) AND Can insulin pumps work better than injections for kids with diabetes? – Reuters (free)

 


 

1 – Today is #WorldObesityDay: Tenfold increase in childhood and adolescent obesity in four decades: new study by Imperial College London and WHO – World Health Organization (free)

Original article: Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults – The Lancet (free) AND Invited Commentary: Double-duty solutions for the double burden of malnutrition (free)

Related report: Ending Childhood Obesity Implementation Plan: executive summary – World Health Organization (free PDF)

 

2 – #WorldObesityDay – Global cost of obesity-related illness to hit $1.2tn a year from 2025 – The Guardian (free)

See related Global Burden of Disease Study: Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free), Editorial: Global Health Effects of Overweight and Obesity (free) AND Commentary: New study finds more than 2 billion people overweight or obese – Institute for Health Metrics and Evaluation (free) 

 

3 – #WorldObesityDay – Meta-analysis on shift work and risks of specific obesity types – Obesity Reviews (link to abstract – $ for full-text)

Commentaries: Meta-Analysis Links Night Shift to Obesity Risk, Especially “Belly Fat” – AJMC (free) AND Night Shift Work Linked To Increased Risk of Obesity – Medical Research (free) AND Shift Work Increases Risk of Apple-Shaped Overweight/Obesity – Medscape (free registration required) AND Night shift work linked to an increased risk of obesity – Wiley, via EurekAlert (free)

 

4 – Guidelines: The do’s, don’ts and don’t knows of direct observation of clinical skills in medical education – Perspectives on Medical Education (free) (RT @brhospitalist and @CvanderVleuten see Tweet)

 

5 – Opinion: Updating Wikipedia should be part of all doctors’ jobs – STAT (free) (RT @Onisillos)

 

6 – Candida auris Clinical Update – September 2017 – Centers for Disease Control and Prevention (free)

Commentary: CDC Updates Guidance as Candida auris Cases Grow – Medscape (free registration required)

Related: Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally – PLOS Pathogens (free) AND A ‘perfect storm’ superbug: How an invasive fungus got health officials’ attention – STAT (free) AND CDC keeping a watchful eye on Candida auris – CIDRAP (free) AND CDC reports uptick in Candida auris cases – CIDRAP (free)

 

7 – Review: The Treatment of Illnesses Arising in Pregnancy – Deutsches Ärzteblatt international (free)

 

8 – Changes in marital quality over 6 years and its association with cardiovascular disease risk factors in men: findings from the ALSPAC prospective cohort study – Journal of Epidemiology & Community Health (free)

Commentaries: Marital ups and downs affect heart health – OnMedica (free) AND Marital ups and downs may impact men’s heart health – Medical News Today (free) AND Cardiovascular risk factors for married men linked to changes in relationship quality over time – News Medical (free)

 

9 – Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study – PLOS Medicine (free)

Commentaries: Gabapentin, Opioid Combo May Up the Risk of Opioid-Related Death – MPR (free) AND Gabapentin Plus Opioids a Deadly Combination? – MPR (free)

 

10 – Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial – Canadian Medical Association Journal (free)

Commentaries: Ibuprofen Better Than Morphine After Minor Surgery in Kids – Medscape (free registration required) AND Ibuprofen better choice over oral morphine for pain relief in children after minor surgery – MedicalXpress (free)

 


 

1 – Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold – CHEST Expert Panel Report (free)

See also other recent CHEST guidelines on the management of cough in specific populationsChronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough: CHEST Guideline and Expert Panel Report (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis: CHEST Guideline and Expert Panel Report (free)

 

2 – New NICE Guidelines on Guild Abuse, Neglect and Maltreatment

– Child abuse and neglect – National Institute for Health and Care Excellence (free)

– Child maltreatment: when to suspect maltreatment in under 18s – National Institute for Health and Care Excellence (free)

News release: Responding to child abuse and neglect – a view from NICE (free)

 

3 – Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data – The Lancet Respiratory Medicine (free)

Commentaries: Vitamin D and asthma: a case to answer – The Lancet Respiratory Medicine (free) AND Vitamin D may prevent asthma worsening for some – NHS Choices (free)

 

4 – Upstream watershed condition predicts rural children’s health across 35 developing countries – Nature Communications (free)

Commentaries: Healthy watersheds help stem deadly childhood diseases downstream – WWF Global (free) AND Global kids study: More trees, less disease – University of Vermont (free) AND More trees help water sanitation, reduce child deaths: study – Reuters (free)

 

5 – Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Midday Light Therapy May Improve Depressive Symptoms in Patients With Bipolar Disorder – Psychiatric News Allert (free) AND Bright Light Therapy Improves Bipolar Depression – Medscape (free registration required)

 

6 – Predicting 30-Day Mortality for Patients With Acute Heart Failure in the Emergency Department: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Tool may help accurately predict 30-day mortality for emergency department patients with acute heart failure – 2 Minute Medicine (free) AND Simple tool accurately predicts 30-day mortality for patients with acute heart failure in the ER – MedicalXpress (free)

See Calculator: MEESSI-AHF RISK MODEL

 

7 – The Painful Side Of Positive Health Care Marketing – NPR (free)

Related: I have cancer. This comic shows how much pressure I feel to be a hero – VOX (free) AND Why cancer is not a war, fight, or battle – CNN (free) AND He’s a Fighter – The Atlantic (free)

 

8 – Richard Lehman’s journal review, 9 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Interventions to reduce harm in people who use tobacco. The latest Cochrane Evidence – Cochrane Tobbaco Edition (free summaries) (RT @CochraneUK see Tweet)

Comprehensive resource on evidence-based interventions to reduce tobacco related harm.

 

10 – Female sex, early-onset hypertension, and risk of dementia – Neurology (link to abstract – $ for full-text)

Commentaries: For women, high blood pressure in your 40s may be tied to increased risk of Dementia – American Academy of Neurology, via ScienceDaily (free) AND Women’s dementia risk increased by midlife hypertension – Medical News Today (free) AND Mid-adulthood hypertension linked to dementia risk in women – Clinical Advisor (free)

Related Study: Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort – JAMA Neurology (link to abstract – $ for full-text) AND Commentaries: Midlife cardiovascular risk factors may increase chances of dementia – NIH News Releases (free) AND Midlife smoking, diabetes, and hypertension associated with late life dementia – 2 Minute Medicine (free) AND Heart disease risk in middle age tied to dementia later – Reuters (free)

 


 

1 – Study links dental antibiotics to C diff cases – CIDRAP (free) AND Antibiotics for dental procedures linked to superbug infection – Infectious Diseases Society of America, via ScienceDaily (free)

Study Presented at #IDWeek2017

 

2 – Women who get frequent UTIs may reduce risk by drinking plenty of water – Infectious Diseases Society of America, via ScienceDaily (free) AND Recurrent Cystitis? Drink More Water – MedPage Today (free registration required) AND Drinking More Water Really Does Ward Off UTIs – LiveScience (free)

Study Presented at #IDWeek2017

 

3 – Efficacy and safety of switching from boosted protease inhibitors plus emtricitabine and tenofovir disoproxil fumarate regimens to single-tablet darunavir, cobicistat, emtricitabine, and tenofovir alafenamide at 48 weeks in adults with virologically suppressed HIV-1 (EMERALD): a phase 3, randomised, non-inferiority trial – The Lancet HIV (free)

Commentaries: Towards a universal second-line fixed-dose combination ART – The Lancet HIV (free) AND Single-Tablet ART: New Hope in HIV Therapy? All-in-one fixed dose combo proves safe, effective in EMERALD trial – MedPage Today (free registration required) AND EMERALD Trial: Week 48 Results Demonstrate Efficacy in Single-Tablet HIV Therapy – Infectious Diseases Advisor (free)

Study Presented at #IDWeek2017

 

4 – How Smartphones Hijack Our Minds – The Wall Street Journal (free) (RT @EricTopol see Tweet)

“Research suggests that as the brain grows dependent on phone technology, the intellect weakens”

 

5 – Impact of the Commercialization of Three Generic Angiotensin II Receptor Blockers on Adverse Events in Quebec, Canada: A Population-Based Time Series Analysis – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Generic Blood Pressure Drugs May Be Tied to Increase in Adverse Events – Physician’s First Watch (free) AND Generic ARBs Linked to Increased Adverse Events – TCTMD (free)

As in any observational study, association does not necessarily imply causation.

 

6 – Anticoagulant Use and Risk of Ischemic Stroke and Bleeding in Patients With Secondary Atrial Fibrillation Associated With Acute Coronary Syndromes, Acute Pulmonary Disease, or Sepsis – JACC: Clinical Electrophysiology (link to abstract – $ for full-text)

Commentaries: Anticoagulation didn’t benefit patients with afib secondary to ACS, pulmonary disease, or sepsis – ACP Hospitalist (free) AND No Anticoagulation Benefit, High Bleeding Risk Seen in Patients With Secondary A-fib – TCTMD (free)

 

7 – Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population – Mayo Clinic Proceedings (link to abstract – $ for full-text)

Commentaries: Low serum calcium may increase risk of sudden cardiac arrest – EurekAlert (free) AND Low calcium may raise cardiac arrest risk by twofold – Medical News Today (free)

 

8 – Impact of the US Maternal Tetanus, Diphtheria, and Acellular Pertussis Vaccination Program on Preventing Pertussis in Infants <2 Months of Age: A Case-Control Evaluation – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Study: Tdap vaccine in pregnancy protects infants – CIDRAP (free) AND Fewer newborns get whooping cough when moms get vaccinated – Reuters (free)

 

9 – Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate – Addiction (link to abstract – $ for full-text) checar acesso

Commentary: Pills prescribed for alcoholism might not work, study finds – The Guardian (free)

 

10 – ‘Antibiotic apocalypse’: doctors sound alarm over drug resistance – The Guardian (free)

Related WHO Reports: Antibacterial Agents in Clinical Development (free) AND Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics (free) AND Commentary: WHO report paints dire picture of antibiotic development – CIDRAP (free)

 


 

1 – Report: Ending Cholera: A Global Roadmap to 2030 – World Health Organization (free) (RT @Onisillos)

News release: Partners commit to reduce cholera deaths by 90% by 2030 (free)

See also: WHO’s work on cholera (free resources)

 

2 – Potential deaths averted in USA by replacing cigarettes with e-cigarettes – Tobacco Control (free)

Commentaries: Switch to vaping could prevent millions of premature deaths – OnMedica (free) AND Tobacco smokers could gain 86 million years of life if they switch to vaping, study finds – eCancer News (free) AND Switching to e-cigarettes could save 6.6 million American smokers: researchers – Reuters (free)

Related review: Key issues surrounding the health impacts of electronic nicotine delivery systems (ENDS) and other sources of nicotine – CA: A Cancer Journal for Clinicians (free)

 

3 – Coronary Computed Tomography Angiography vs Functional Stress Testing for Patients With Suspected Coronary Artery Disease: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free)

Invited commentary: Coronary Computed Tomographic Angiography—The First Test for Evaluating Patients With Chest Pain? (free)

Commentary: Coronary CT Angiography vs. Stress Testing: Meta-Analysis Offers Mixed Results – Physician’s First Watch (free)

Coronary Computed Tomografic Angiography (CCTA) was associated with a very small reduction in the incidence of myocardial infarction (0.7% vs 1.1% = 0.4% absolute risk reduction), but without differences in death or cardiac hospitalization. Patients undergoing CCTA were significantly more likely to undergo invasive coronary angiography (11.7% vs 9.1%), revascularization (7.2% vs 4.5%) and were also more likely to receive a diagnosis of new CAD and to have initiated aspirin or statin therapy.

 

4 – Korean Guidelines for Diagnosis and Management of Chronic Heart Failure – The Korean Society of Cardiology (free)

Source: Critical Care Review Newsletter

 

5 – No Calm After the Storm: A Systematic Review of Human Health Following Flood and Storm Disasters – Prehospital and Disaster Medicine (free)

Commentary: After a disaster, contaminated floodwater can pose a threat for months to come – The Conversation (free)

Related guideline: Hurricane Season Public Health Preparedness, Response, and Recovery Guidance for Health Care Providers, Response and Recovery Workers, and Affected Communities — CDC, 2017 (free) AND Commentary: CDC issues guidance on storm recovery – Reuters (free)

 

6 – Olfactory Dysfunction Predicts Subsequent Dementia in Older U.S. Adults – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Commentaries: Elderly Who Have Trouble Identifying Odors Face Risk of Dementia – NewsWise (free) AND Poor Sense of Smell May Signal Impending Dementia – The New York Times (10 articles per month are free) AND Sniffing out dementia with a simple smell test – Medical News Today (free)

 

7 – Gestational Age and Cardiorespiratory Fitness in Individuals Born At Term: A Life Course Study – Journal of The American Heart Association (free)

Commentaries: Early babies could face lifelong fitness risks – The University of Queensland (free) AND Early-Term Birth Tied to Poor Cardiorespiratory Fitness Later – Medscape (free registration required) AND Early ‘full-term’ babies have poorer fitness into young adulthood – Cardiovascular Business (free)

 

8 – The risk of new-onset diabetes in antidepressant users – A systematic review and meta-analysis – PLOS One (free)

Commentary: Type 2 Diabetes and Antidepressant Drug Use: Is There a Causal Link? – Endocrinology Advisor (free)

 

9 – Carbohydrate-last meal pattern lowers postprandial glucose and insulin excursions in type 2 diabetes – BMJ Open Diabetes Research & Care (free)

Commentary: People with type 2 diabetes should ‘save carbs for last’, study claims – NHS Choices (free)

 

10 – Review: Palliative Care in Neurology – Mayo Clinic Proceedings (free)

 


 

1 – Availability of evidence of benefits on overall survival and quality of life of cancer drugs approved by European Medicines Agency: retrospective cohort study of drug approvals 2009-13 – The BMJ (free)

Editorials: Do cancer drugs improve survival or quality of life? (free) AND Cancer drugs: high price, uncertain value (free)

Commentaries: Over half of new cancer drugs ‘show no benefits’ for survival or wellbeing – The Guardian (free) AND Only half of new cancer drugs extend or improve life – OnMedica (free) AND Some cancer drugs approved in Europe might not have sufficient evidence of survival benefits, says study – Cancer Research UK (free)

 

2 – Antenatal nutritional supplementation and autism spectrum disorders in the Stockholm youth cohort: population based cohort study – The BMJ (free)

Commentaries: Multivitamins in pregnancy may be linked to lower autism risk in children – ScienceDaily (free) AND Could multivitamin use in pregnancy protect children from autism? – Medical News Today (free) AND Multivitamin Use in Pregnancy Might Be Tied to Lower Autism Risk in Offspring – Physician’s First Watch (free)

 

3 – Simple preventive actions by parents linked to fewer child injuries – NIHR Signal (free)

Original article: Keeping Children Safe: a multicentre programme of research to increase the evidence base for preventing unintentional injuries in the home in the under-fives – Programme Grants for Applied Research (free)

“Children more than twice as likely to attend hospital for stair falls if safety gate not used. Home hazards studied” (RT @NIHR_DC see Tweet)

 

4 – Review: Current Practice of State-of-the-Art Surgical Coronary Revascularization – Circulation (free)

 

5 – Vital Signs: Trends in Incidence of Cancers Associated with Overweight and Obesity — United States, 2005–2014 – Centers for Disease Control and Prevention (CDC) (free)

News Release: Cancers Associated with Overweight and Obesity Make up 40 percent of Cancers Diagnosed in the United States (free)

Commentaries: Excessive Weight Gain, Obesity, and Cancer Opportunities for Clinical Intervention – JAMA Viewpoint (free) AND Cancer: 40 percent of all cases related to obesity, overweight – Medical News Today (free)

 

6 – 2017 Update on Medical Overuse: A Systematic Review – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Study highlights 10 most unnecessary and overused medical tests and treatments – University of Maryland School of Medicine, via EurekAlert (free)

 

7 – The Burden of Primary Liver Cancer and Underlying Etiologies From 1990 to 2015 at the Global, Regional, and National Level: Results From the Global Burden of Disease Study 2015 – JAMA Oncology (free)

Commentary: Global burden of disease study focuses on liver cancer – eCancer News (free)

 

8 – Association Between Use of Non–Vitamin K Oral Anticoagulants With and Without Concurrent Medications and Risk of Major Bleeding in Nonvalvular Atrial Fibrillation – JAMA (link to abstract – $ for full-text)

Commentaries: Use of Non-Vitamin K Blood-Thinners with Certain Medications Associated With Increased Risk of Major Bleeding – The JAMA Network (free) AND Drug reactions with NOACs in AFib patients could result in major bleeding problems – Cardiovascular Business (free)

 

9 – Association Between Use of Antithrombotic Medication and Hematuria-Related Complications – JAMA (link to abstract – $ for full-text)

Commentaries: Haematuria more common in people taking antithrombotics – OnMedica (free) AND Blood-Thinning Medications Associated With Increased Risk of Complications from Having Blood in Urine – The JAMA Network (free)

 

10 – Association of trauma and posttraumatic stress disorder with incident systemic lupus erythematosus (SLE) in a longitudinal cohort of women – Arthritis & Rheumatology (link to abstract – $ for full-text)

Commentaries: A Stress Link to Lupus – The New York Times (10 articles per month are free) AND PTSD linked with increased lupus risk – Willey, via EurekAlert (free) AND Lupus risk almost three times higher after trauma – Medical News Today (free)

 


 

1 – Safety and Immunogenicity of an Anti–Zika Virus DNA Vaccine — Preliminary Report – New England Journal of Medicine (free)

Commentaries: First human trial of DNA-based Zika vaccine shows promise – CIDRAP (free) AND DNA-based Zika vaccine candidate found safe and effective at inducing immune response – University of Pennsylvania School of Medicine, via EurekAlert (free) AND Zika vaccine shows promise in early human trial – Reuters (free)

 

2 – Challenges in the Design and Interpretation of Noninferiority Trials – New England Journal of Medicine (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

“All too often non-inferiority clinical trials are a means of asserting false equivalence” (RT @EricTopol see Tweet)

 

3 – Guidelines for the Management of Congenital Heart Diseases in Childhood and Adolescence – The German Society of Paediatric Cardiology (free PDF)

 

4 – New Choosing Wisely Recommendations

Choosing Wisely US: Five Things Physicians and Patients Should Question: American Academy of Pediatrics – Section on Endocrinology (free) AND Commentary: Choosing Wisely: 5 Pediatric Endocrinology Tests to Avoid – Physician’s First Watch (free)

Choosing Wisely Canada: Nine Things Nurse Practitioners and Patients Should Question – Nurse Practitioner Association of Canada (free)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

 

5 – Outcomes In Two Massachusetts Hospital Systems Give Reason For Optimism About Communication-And-Resolution Programs – Health Affairs (link to abstract – $ for full-text)

Commentaries: After medical error, apology goes a long way – Stanford University Medical Center, via ScienceDaily (free) AND Conflict Resolution Program: ‘Cause for Optimism’ – MedPage Today (free registration required)

Explaining and apologizing to patients after a medical error does not increase lawsuits, large US study finds” (RT @bmj_latest see Tweet)

 

6 – Exercise and the Prevention of Depression: Results of the HUNT Cohort Study – American Journal o Psychiatry (free)

Commentary: Just One Hour of Exercise a Week May Help Prevent Depression – TIME Magazine (free) AND One hour of exercise a week can prevent depression – EurekAlert (free) AND What’s the ultimate way to defy depression, disease and early death? Exercise – The Guardian (free)

 

7 – The high price of anticancer drugs: origins, implications, barriers, solutions – Nature Reviews: Clinical Oncology (free PDF)

Related: Cancer drugs are getting better and dearer – The Economist (a few articles per month are free) Financial toxicity: 1 in 3 cancer patients have to turn to friends or family to pay for care – STAT News (free) AND Not Just Nausea And Vomiting: Cancer Docs Now Worry About ‘Financial Toxicity’ – WBUR (free) AND Financial Toxicity and Cancer Treatment (PDQ®) – National Institute of Cancer (free) AND Financial Toxicity: Cancer Supportive Care Professionals Consider the Side Effects of Soaring Costs – ASCO Post (free)

 

8 – Meta-Analysis of the Antidepressant Effects of Acute Sleep Deprivation – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)

Commentaries: Summary of studies on sleep deprivation didn’t caution that depression benefits are short lived – HealthNewsReview (free) AND Sleep Deprivation May Treat Depression. But Would It Ever Be Prescribed? – Forbes (free) AND Sleep Deprivation a Rapid, Effective Depression Treatment – Medscape (free registration required) AND Sleep deprivation rapidly reduces depression symptoms in nearly half of depressed patients – News Medical (free)

 

9 – Respiratory support in patients with acute respiratory distress syndrome: an expert opinion – Critical Care (free)

Related article published recently: Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free) AND Editorial: Lung Recruitment and Titrated PEEP in Moderate to Severe ARDS: Is the Door Closing on the Open Lung? (free)

 

10 – Association Between Use of Antithrombotic Medication and Hematuria-Related Complications – JAMA (link to abstract – $ for full-text)

Commentaries: Antithrombotics Associated with Gross Hematuria – Physician’s First Watch (free) AND Haematuria more common in people taking antithrombotics – OnMedica (free)

 


 

1 – The Importance of Breakfast in Atherosclerosis Disease: Insights From the PESA Study – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Skipping Breakfast May Be Bad For The Heart – But There Are Caveats – Forbes (free) AND Most important meal of the day? Skipping breakfast may be linked to poor heart health – The Guardian (free) AND Cardiologists, moms agree: Breakfast the most important meal of the day – Cardiovascular Business (free) Skipping breakfast associated with hardening of the arteries – American College of Cardiology, via ScienceDaily (free)

 

2 – Development and validation of QMortality risk prediction algorithm to estimate short term risk of death and assess frailty: cohort study – The BMJ (free)

Editorial: Identifying frailty in primary care (free)

Commentary: Frailty calculator to support GPs in targeting patients for better care – MyScience (free)

See calculators: QMortality®-2017 risk calculator (free) AND QFrailty®-2017 risk calculator (free)

“the tool can reliably estimate risk of dying within 12 months and risk of unplanned admissions among patients aged between 65 and 100 years old” (from MyScience).

 

3 – Efficiency and safety of varying the frequency of whole blood donation (INTERVAL): a randomised trial of 45 000 donors – The Lancet (free)

Commentaries: The price of blood is measured in iron – The Lancet (free) AND Increasing frequency of blood donation has no major side effects – ScienceDaily (free)

 

4 – Managing Head Trauma in Children – The New York Times (10 articles per month are free)

Related Articles: Reducing Head CT Use for Children With Head Injuries in a Community Emergency Department – Pediatrics (link to abstract – $ for full-text) AND Development and Internal Validation of a Clinical Risk Score for Treating Children With Mild Head Trauma and Intracranial Injury – JAMA Pediatrics (free PDF) AND Identification of children at very low risk of clinically-important brain injuries after head trauma: a prospective cohort stud – The Lancet (free PDF)

 

5 – How well do flu shots work? Here’s what the science says – VOX (free)

  

6 – Guidelines for the diagnosis and management of critical illness-related corticosteroid insufficiency (CIRCI) in critically ill patients (Part I): Society of Critical Care Medicine (SCCM) and European Society of Intensive Care Medicine (ESICM) 2017 (free)

 

7 – Richard Lehman’s journal review, 2 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Guidelines for Diagnostic Imaging During Pregnancy and Lactation – American College of Obstetricians and Gynecologists (free)

See also: Guideline Summary (free)

 

9 – The British Society for Rheumatology guideline for the management of adults with primary Sjögren’s Syndrome – Rheumatology (free)

See also: Guideline Summary (free)

Commentary: Guidelines for treatment of primary Sjögren’s syndrome: a first useful stone but still much to do – Rheumatology (free)

 

10 – Review: Acute Coronary Syndromes: The Way Forward From Mechanisms to Precision Treatment – Circulation (free)

 


 

1 – International Day of Older Persons – 1st October 2017: Health services must stop leaving older people behind – World Health Organization (free)

Related Guideline: WHO Guidelines on Integrated Care for Older People (ICOPE) – World Health Organization (free)

See also: WHO’s work on ageing

 

2 – Guideline: Preventive chemotherapy to control soil-transmitted helminth infections in at-risk population groups – World Health Organization (free)

News release: WHO recommends large-scale deworming to improve children’s health and nutrition (free)

Infographic: WHO publishes recommendations for large-scale deworming to improve children’s health and nutrition (free)

See also: WHO intestinal worms website (free resources) AND Fact sheet: Soil-transmitted helminth infections (free)

 

3 – Evaluation of telephone first approach to demand management in English general practice: observational study – The BMJ (free)

Editorial: Telephone first consultations in primary care (free)

Commentaries: Phone-first GP consults ‘no panacea for reducing workload’ – OnMedica (free) AND No evidence to support claims that telephone consultations reduce GP workload or hospital referrals – University of Cambridge (free)

Related study: Direct-To-Consumer Telehealth May Increase Access To Care But Does Not Decrease Spending – Health Affairs (link to abstract – $ for full-text) AND Commentaries: Telehealth Doctor Visits May Be Handy, But Aren’t Cheaper Overall – NPR (free) AND Are Virtual Doctor Visits Really Cost-Effective? Not So Much, Study Says – Health News Florida (free)

 

4 – Medical News & Perspectives: Study Questions Use of Acid Suppressors To Curb Mild Infant Reflux – JAMA (free) (RT @DeeMangin see Tweet)

See study abstract presented at the Pediatric Academic Societies meeting: Infants prescribed antacids for reflux have increased risk of bone fractures (free)

 

5 – Perspectives: Lost in Thought: The Limits of the Human Mind and the Future of Medicine – New England Journal of Medicine (free)

 

6 – A single mutation in the prM protein of Zika virus contributes to fetal microcephaly – Science (link to abstract – $ for full-text)

Commentaries: A Single Mutation Helps Modern Zika Cause Birth Defects – Scientific American (free) AND The Zika Virus Grew Deadlier With a Small Mutation, Study Suggests – The New York Times (10 articles per month are free) AND Zika was a mild bug. A new discovery shows how it turned monstrous – The Washington Post (free) AND How Zika Became So Dangerous For Babies – NPR (free)

 

7 – Association of Vision Loss With Cognition in Older Adults – JAMA Ophthalmology (link to abstract – $ for full-text)

Commentaries: Vision and Hearing Loss Are Tied to Cognitive Decline – The New York Times (10 articles per month are free) AND Visual impairment among older adults associated with poor cognitive function – Medical News Today (free)

 

8 – Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies – Journal of The American Heart Association (free)

Our findings indicate that both short and long sleep duration is associated with an increased risk of allcause mortality and cardiovascular events”.

 

9 – Effect of a Community Health Worker–Led Multicomponent Intervention on Blood Pressure Control in Low-Income Patients in Argentina: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Community Intervention among Low-Income Patients Results in Improved Blood Pressure Control – The JAMA Network (free)

“The proportion of patients with controlled hypertension (BP <140/90 mm Hg) increased from 17 percent at baseline to 73 percent in the intervention group and from 18 percent to 52 percent in the usual care group”.

 

10 – Self-monitoring of blood pressure in hypertension: A systematic review and individual patient data meta-analysis – PLOS Medicine (free)

Commentary: Home blood pressure monitoring works best with extra support – Reuters (free)

 


 

1 – Meditation and Cardiovascular Risk Reduction: A Scientific Statement From the American Heart Association (free)

News releases: Meditation may decrease the risk of heart disease – AHA News (free) AND Meditation might be useful addition to heart-healthy lifestyle and medical treatment – AHA / ASA Newsroom (free)

Commentary: AHA: Meditation Might Lower Cardiovascular Risk – Physician’s First Watch (free)

 

2 – NICE Guideline: Urinary tract infection in under 16s: diagnosis and management (free)

News Release: Test children’s urine before prescribing antibiotics for UTIs, says NICE (free)

 

3 – NICE Guideline: Faltering growth: recognition and management of faltering growth in children (free)

News Release: Allow underweight children to be ‘messy’ with their food, says NICE (free)

See also: Faltering growth in children: summary of NICE guidance – The BMJ (free infographic and key points – $ for full-text)

 

4 – Effect of Routine Low-Dose Oxygen Supplementation on Death and Disability in Adults With Acute Stroke: The Stroke Oxygen Study Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Low-dose oxygen no benefit in adults with acute stroke – MedicalXpress (free) AND UK study ‘settles debate’ over whether to give routine oxygen to stroke patients – Nursing Times (free)

Routine oxygen was also of no benefit in a recent trial in patients with acute myocardial infarction, see Original Article (link to abstract – $ for full-text) and Quick Take Video Summary (free)

 

5 – State of the Art Review: Asthma-COPD overlap syndrome: pathogenesis, clinical features, and therapeutic targets – The BMJ (free)

 

6 – Risk factors for admission to hospital with laboratory-confirmed influenza in young children: birth cohort study – European Respiratory Journal (link to abstract – $ for full-text)

Commentaries: Protect babies from flu by getting older siblings vaccinated, parents advised – The Guardian (free) AND Older Siblings a Risk Factor for Serious Flu Infections in Infants – The New York Times (10 articles per month are free)

 

7 – Methods to improve healthcare worker hand hygiene to decrease infection in patient care – Cochrane Library (free)

Original article: Interventions to improve hand hygiene compliance in patient care – Cochrane Library (link to abstract – $ for full-text)

 

8 – World Rabies Day (28 September) – World Health Organization (free news release and infographics)

Updated Fact Sheet: Rabies – World Health Organization (free)

Related Website: Global Alliance for Rabies Control

See also: How to end human deaths from rabies: lessons from Kenya – The Conversation (free) (RT @Onisillos see Tweet)

 

9 – Position Statement: Energy and sports drinks in children and adolescents – Canadian Paediatric Society (free)

Commentaries: Energy, sports drinks should be avoided by children and teens, Canadian Paediatric Society warns – The Globe and Mail (free) AND Sports drinks and energy drinks unhealthy for kids and teens, Canadian pediatricians say – CBCNews (free)

 

10 – Local nerve blocks can improve outcomes for people with hip fracture – NIHR Signal (free)

Original article: Peripheral nerve blocks for hip fractures – Cochrane Library (link to abstract – $ for full-text)

One case of pneumonia prevented for every 7 hip fracture patients given pain relief with nerve block” (RT @NIHR_DC see Tweet)

 


 

#LIVES2017 – Highlights from 30th European Society of Intensive Care Medicine Annual Congress

 

1 – #LIVES2017 – Effect of an Early Resuscitation Protocol on In-hospital Mortality Among Adults With Sepsis and Hypotension: A Randomized Clinical Trial – JAMA (free)

Editorial: Trying to Improve Sepsis Care in Low-Resource Settings (free)

An early resuscitation protocol for adults w sepsis in Zambia increased mortality” (RT @JAMA_current see Tweet)

 

2 – #LIVES2017 – Effect of Lung Recruitment and Titrated Positive End-Expiratory Pressure (PEEP) vs Low PEEP on Mortality in Patients With Acute Respiratory Distress Syndrome: A Randomized Clinical Trial – JAMA (free)

Editorial: Lung Recruitment and Titrated PEEP in Moderate to Severe ARDS: Is the Door Closing on the Open Lung? (free)

Commentary: Open Lung Ventilation May Worsen ARDS Mortality – MedPage Today (free registration required)

“A strategy using a lung recruitment maneuver and titrated PEEP, in association with volume-assist control ventilation, increased mortality of patients with moderate to severe ARDS”.

 

3 – #LIVES2017 – Effect of Individualized vs Standard Blood Pressure Management Strategies on Postoperative Organ Dysfunction Among High-Risk Patients Undergoing Major Surgery: A Randomized Clinical Trial – JAMA (free)

Editorial: Perioperative Management of High-Risk Patients: Going Beyond “Avoid Hypoxia and Hypotension” (free)

Commentary: Individualized SBP tx cuts risk for post-op organ dysfunction – MedicalXpress (free)

 

4 – #LIVES2017 – Effect of Systematic Intensive Care Unit Triage on Long-term Mortality Among Critically Ill Elderly Patients in France: A Randomized Clinical Trial – JAMA (free)

Editorial: Admitting Elderly Patients to the Intensive Care Unit—Is it the Right Decision? (free)

 

5 – #LIVES2017 – Age of Red Cells for Transfusion and Outcomes in Critically Ill Adults – New England Journal of Medicine (free)

Commentaries: Red blood cells for transfusion like a good red: A little older, a little better – Monash University, via ScienceDaily (free) AND Is Older Blood OK to Use in a Transfusion? – WebMD (free)

 

6 – Global, regional, and subregional classification of abortions by safety, 2010–14: estimates from a Bayesian hierarchical model – The Lancet (free)

Commentaries: Worldwide, an estimated 25 million unsafe abortions occur each year – World Health Organization (free) AND Estimating abortion safety: advancements and challenges – The Lancet (free) AND More than 25 million unsafe abortions performed worldwide each year – STAT (free)

 

7 – Treating tobacco dependence: guidance for primary care on life-saving interventions. Position statement of the IPCRG – Primary Care Respiratory Medicine (free)

 

8 – A Treatment Algorithm for Emergent Invasive Cardiac Procedures in the Resuscitated Comatose Patient – Journal of The American College of Cardiology (free)

Commentary: Cardiac Arrest: A Treatment Algorithm for Emergent Invasive Cardiac Procedures in the Resuscitated Comatose Patient – American College of Cardiology, Latest in Cardiology (free)

 

9 – New Approaches to Prevent Healthcare-Associated Infection – Clinical Infectious Diseases (free)

 

10 – Guidelines for the prevention of travel-associated illness in older adults – Tropical Diseases, Travel Medicine and Vaccines (free)

 


 

1 – Draft Recommendation Statement: Falls Prevention in Community-Dwelling Older Adults: Interventions – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Draft Recommendations for Falls and Fracture Prevention – Medscape (free registration required) AND USPSTF Draft Statement: Vitamin D Supplements No Longer Recommended to Prevent Falls in Seniors – Physician’s First Watch (free)

Related guidelines: Falls in older people: assessing risk and prevention – NICE (free) AND Evidence-based guidelines for fall prevention in Korea (free) AND Summary of the Updated American Geriatrics Society/British Geriatrics Society Clinical Practice Guideline for Prevention of Falls in Older Persons (free PDF) AND Management of Falls in Community-Dwelling Older Adults: Clinical Guidance Statement From the Academy of Geriatric Physical Therapy of the American Physical Therapy Association (free) AND Prevention of fall-related injuries in the elderly: An Eastern Association for the Surgery of Trauma practice management guideline (free)

 

2 – Review: A Test in Context: Lipid Profile, Fasting Versus Nonfasting – Journal of The American College of Cardiology (link to abstract and free infographic – $ for full-text)

Commentary: Is fasting before a lipid panel necessary? – Cardiovascular Business (free)

Related guideline: Fasting is not routinely required for determination of a lipid profile: clinical and laboratory implications including flagging at desirable concentration cut-points—a joint consensus statement from the European Atherosclerosis Society and European Federation of Clinical Chemistry and Laboratory Medicine (free) AND Commentary: New guidelines simplify cholesterol tests: no fasting needed – STAT (free)

  

3 – The effects of a rise in cigarette price on cigarette consumption, tobacco taxation revenues, and of smoking-related deaths in 28 EU countries– applying threshold regression modelling – BMC Public Health (free)

See also: Smoking prevalence and attributable disease burden in 195 countries and territories in our April 7th issue (see #1) AND WHO report on the global tobacco epidemic 2017 in our July 20th issue (see #1) AND  “Tobacco Endgame” policies in our May 12th issue (see #3).

 

4 – Efficacy of recommended drugs against soil transmitted helminths: systematic review and network meta-analysis – The BMJ (free)

Commentary: Reduced Efficacy of Anthelmintic Drugs – MyScience (free)

 

5 – Childhood onset inflammatory bowel disease and risk of cancer: a Swedish nationwide cohort study 1964-2014 – The BMJ (free)

Editorial: Increased risk of cancer in children with inflammatory bowel disease (free)

Commentaries: Inflammatory Bowel Disease in Childhood Tied to Higher Cancer Risk Later – Physician’s First Watch (free) AND IBD in Childhood Raises Cancer Risk – Medscape (free registration required)

 

6 – Effect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty: The GIFT Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Genotyping Reduces Adverse Events with Warfarin – Cardiobrief (free) AND Genotype-Guided Warfarin Dosing Reduces Adverse Events After Hip, Knee Arthroplasty – Physician’s First Watch (free)

 

7 – Clinical Report: Infectious Diseases Associated With Organized Sports and Outbreak Control – American Academy of Pediatrics (free)

News release: AAP Offers New Guidance on Preventing Spread of Infectious Diseases Associated with Organized Sports (free)

Commentary: When Athletes Share Infections – The New York Times (10 articles per month are free)

 

8 – Mapping under-5 and neonatal mortality in Africa, 2000–15: a baseline analysis for the Sustainable Development Goals – The Lancet (free)

Commentaries: Precision public health: mapping child mortality in Africa – The Lancet (free) AND ‘Precision public health:’ 5 x 5 kilometer mapping identifies significant differences in child deaths throughout Africa – Institute for Health Metrics and Evaluation (free)

 

9 – Pregnant Women Should Still Get The Flu Vaccine, Doctors Advise – NPR (free)

Statement: It is Safe to Receive Flu Shot During Pregnancy – American College of Obstetricians and Gynecologists (free)

See original study showing a possible association between flu vaccine and miscarriage in our September 21st issue (see #6)

 

10 – Diagnostic Accuracy of Novel and Traditional Rapid Tests for Influenza Infection Compared With Reverse Transcriptase Polymerase Chain Reaction: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Newer influenza diagnostic tests more accurate than traditional tests – Clinical Advisor (free) AND Rapid tests linked to quicker and more accurate results for influenza diagnosis than traditional tests – 2 Minute Medicine (free)

 


 

1 – News release: Draft Guideline: Most common ear infections should not be treated with antibiotics, says NICE (free)

Commentaries: Common ear infections don’t need antibiotics, health watchdog says – The Guardian (free) AND Antibiotics not recommended for acute otitis, says NICE (free)

 

2 – Low-Dose Aspirin Discontinuation and Risk of Cardiovascular Events: A Swedish Nationwide, Population-Based Cohort Study – Circulation (link to abstract – $ for full-text)

Commentaries: Stopping Aspirin Hikes CV risk – Cardiobrief (free) AND Aspirin Discontinuation Tied to Increased Risk for CV Events – Physician’s First Watch (free)

 

3 – This map shows how many years could be added to you life – if the air you breathe was less polluted – World Economic Forum (free)

Related: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)

 

4 – Olfaction and incident Parkinson disease in US white and black older adults – Neurology (link to abstract – $ for full-text)

Commentaries: Parkinson’s: Sniff test could predict risk up to a decade earlier – Medical News Today (free) AND Can a Smell Test Predict Parkinson’s? – MedPage Today (free registration required) AND Scratch-and-sniff test could predict Parkinson’s even earlier – Michigan State University, via EurekAlert (free) AND Parkinson’s Disease May Be Diagnosed With Smell Test 10 Years Before Symptoms – Medical Daily (free)

 

5 – Prenatal Fluoride Exposure and Cognitive Outcomes in Children at 4 and 6–12 Years of Age in Mexico – Environmental Health Perspectives (free)

Commentaries: Four questions to ask when reading or writing about water fluoridation and IQ – HealthNewsReview (free) AND High fluoride levels in pregnancy may lower offspring IQ – Medical News Today (free) AND Fluoride exposure in utero linked to lower IQ in kids, study says – CNN (free)

 

6 – Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: In Pregnant Women with Type 1 Diabetes, Continuous Glucose Monitoring Linked to Better Outcomes – Physician’s First Watch (free) AND All pregnant women with type 1 diabetes should be offered continuous glucose monitoring – OnMedica (free)

 

7 – Richard Lehman’s journal review, 25 September 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – The path to longer and healthier lives for all Africans by 2030: the Lancet Commission on the future of health in sub-Saharan Africa – The Lancet (free registration required)

Invited commentaries: Africa and health: a Commission to accelerate success (free registration required) AND Longer and healthier lives for all Africans by 2030: perspectives and action of WHO AFRO (free registration required)

 

9 – Modeling the Cost-Effectiveness of Interventions to Reduce Suicide Risk Among Hospital Emergency Department Patients – Psychiatric Services (link to abstract – $ for full-text)

Commentary: Life-Saving Post-ER Suicide Prevention Strategies are Cost Effective – National Institute of Mental Health (free)

See also related meta-analysis and studies on strategies to prevent suicide in our August 11th issue (see #6 and #7)

 

10 – Addiction Potential of Cigarettes With Reduced Nicotine Content in Populations With Psychiatric Disorders and Other Vulnerabilities to Tobacco Addiction – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Lowering Nicotine in Cigarettes Could Help Most Vulnerable – MedPage Today (free registration required) AND Could Nicotine Reduction Help Curb Addiction? – Science Newsline (free)

 


 

1 – The effect of physical activity on mortality and cardiovascular disease in 130 000 people from 17 high-income, middle-income, and low-income countries: the PURE study – The Lancet (link to abstract – $ for full-text)

Commentaries: Any type of physical exercise is good for the heart – NHS Choices (free) AND Physical Activity of Any Ilk Cuts CVD, Deaths in Global Study: PURE – TCTMD (free) AND Being active saves lives whether a gym workout, walking to work or washing the floor – McMaster University, via ScienceDaily (free) AND Don’t overthink your exercise: just 2.5 hours per week of any kind could help you live longer – VOX (free) AND A daily half hour’s exercise could prevent 1 in 12 early deaths, study shows – Reuters (free)

 

2 – The Mortality and Myocardial Effects of Antidepressants Are Moderated by Preexisting Cardiovascular Disease: A Meta-Analysis – Psychotherapy and Psychosomatics (link to abstract – $ for full-text)

Commentaries: Antidepressant use associated with higher risk of death – OnMedica (free) AND Antidepressants may raise death risk by a third – Medical News Today (free) AND Antidepressants Tied to a Significantly Increased Risk for Death – Medscape (free registration required) AND Antidepressants Associated with Significantly Elevated Risk of Death, Researchers Find – McMaster University, via NewsWise (free)

 

3 – Adherence Tradeoff to Multiple Preventive Therapies and All-Cause Mortality After Acute Myocardial Infarction – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Study Questions Incremental Benefit of Beta-Blockers After Acute MI – TCTMD (free) AND Beta blockers not needed after heart attack if other medications taken – University of North Carolina at Chapel Hill, via Eurekalert (free) AND Adherence to medications post-MI is below 50%; beta-blockers offer little incremental benefit – Cardiovascular Business (free)

Related study published recently: β-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)

 

4 – 2017 AHA/ACC Clinical Performance and Quality Measures for Adults With ST-Elevation and Non–ST-Elevation Myocardial Infarction: A Report of the American College of Cardiology/American Heart Association Task Force on Performance Measures (free)

 

5 – Homepage: Cardiomyopathy Compendium – Circulation Research

– Cardiomyopathies: An Overview, by Eugene Brawnwald (free)

– Classification, Epidemiology, and Global Burden of Cardiomyopathies (free)

– Dilated Cardiomyopathy: Genetic Determinants and Mechanisms (free)

– Hypertrophic Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy (free)

– Hypertrophic Obstructive Cardiomyopathy: Surgical Myectomy and Septal Ablation (free)

– Arrhythmogenic Cardiomyopathy (free)

– Inflammatory Cardiomyopathic Syndromes (free)

– Restrictive Cardiomyopathy: Genetics, Pathogenesis, Clinical Manifestations, Diagnosis, and Therapy (free)

– Cardiomyopathies Due to Left Ventricular Noncompaction, Mitochondrial and Storage Diseases, and Inborn Errors of Metabolism (free)

– Pediatric Cardiomyopathies (free)

– Modern Imaging Techniques in Cardiomyopathies (free)

Source: Critical Care Reviews Newsletter

 

6 – Adverse drug reactions of montelukast in children and adults – Pharmacology Research & Perspectives (free)

Commentaries: Montelukast Tied to Psychiatric Adverse Events in Kids, Adults – Medscape (free registration required) AND Asthma Drug, Montelukast, Tied to Nightmares, Depression – Drugs.com (free)

 

7 – Effect of Post–Cesarean Delivery Oral Cephalexin and Metronidazole on Surgical Site Infection Among Obese Women: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Post-Cesarean Antibiotics Reduce Risk for Surgical Site Infections in Obese Women – Physician’s First Watch (free) AND Antibiotics After C-Section Cut Infections in Obese Women – MedPage Today (free registration required) AND Antibiotics cut infection risk in obese women after caesarean – OnMedica (free)

 

8 – Interventions for treating tuberculous pericarditis – Cochrane Library (free)

News release: Treatment for tuberculosis infection of the membrane around the heart (free)

For HIV-negative patients, corticosteroids may reduce death. For HIV-positive patients not on antiretroviral drugs, corticosteroids may reduce constriction. For HIV-positive patients with good antiretroviral drug viral suppression, clinicians may consider the results from HIV-negative patients more relevant”.

 

9 – Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients: A Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Better outcomes seen in patients who received IV thrombolysis before thrombectomy – ACP Hospitalist (free)

The results support current guideline recommendations to give intravenous thrombolysis to eligible patients even if they are being considered for mechanical thrombectomy, according to the meta-analysis authors” (from ACP)

 

10 – Blood test and ECG may safely rule out heart attack – NIHR Signal (free)

Original article: Rapid Rule-out of Acute Myocardial Infarction With a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text) and Commentary: High-sensitivity troponin T result may help rule out of myocardial infarction – 2 Minute Medicine (free)

 


 

1 – Weight and Metabolic Outcomes 12 Years after Gastric Bypass – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Benefits of gastric bypass persist for 12 years – Reuters (free) AND Gastric bypass surgery benefits continue for 12 years – Diabetes.co.uk (free) AND Bariatric Surgery’s Benefits Last Over a Decade – Physician’s First Watch (free)

 

2 – Do interventions that reduce the cost of smoking cessation treatment increase quit rates, quit attempts or use of treatments? – Cochrane Library (free)

Original article: Healthcare financing systems for increasing the use of tobacco dependence treatment – Cochrane Library (link to abstract – $ for full-text)

Full financial interventions directed at smokers when compared to no financial interventions increase the proportion of smokers who attempt to quit, use smoking cessation treatments, and succeed in quitting”.

 

3 – Lung Cancer Mortality Associated With Smoking and Smoking Cessation Among People Living With HIV in the United States – JAMA Internal Medicine (free)

Editorial: If We Are Smart Enough to Stop HIV From Replicating, Why Can’t We Help People to Stop Smoking? (free)

Commentaries: People with HIV who smoke are more likely to die from lung cancer than from HIV itself – eCancer (free) AND Smoking cuts life expectancy in HIV more than AIDS does – OnMedica (free)

 

4 – Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis – British Journal of Surgery (link to abstract – $ for full-text)

See also a  related meta-analysis suggesting the safety of nonoperative treatment for uncomplicated cases (free) and a recent guideline that incorporates the possibility of non-operative treatment for uncomplicated disease (free)

“1st RCT to show uncomplicated appendicitis resolve even without antibiotics (let alone surgery)” (RT @villesallinen see Tweet)

 

5 – All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease – Hypertension (link to abstract – free PDF via @unpaywall)

Commentaries: Hypertensive disorders of pregnancy increase future risk of heart disease – Cardiovascular Business (free) AND A type of hypertension during pregnancy more dangerous than thought – AHA News (free)

See related articles and commentaries in our August 22nd issue (see #3)

 

6 – Association of Trial Registration With Reporting of Primary Outcomes in Protocols and Publications – JAMA (free)

Commentaries: Discrepancy between trial goals, results may mask treatment risks – Reuters (free) AND Clinical Trials Often Unregistered, Unpublished – The JAMA Network (free)

 

7 – The interstitial lung disease multidisciplinary meeting: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia (free)

 

8 – Cancer patients need better care, not just more technology – Nature News (free)

 

9 – Juvenile Stroke: A Practice-Oriented Overview – Deutsches Ärzteblatt international (free)

Commentary: German study dissects etiology behind juvenile stroke – Cardiovascular Business (free)

 

10 – FDA Drug Safety Communication: FDA recommends separating dosing of potassium-lowering drug sodium polystyrene sulfonate (Kayexalate) from all other oral drugs (free)

Commentary: Don’t Give Kayexalate With Other Oral Drugs, FDA Warns – Medscape (free registration required)

“Patients should take orally administered prescription and over-the-counter (OTC) medicines at least 3 hours before or 3 hours after sodium polystyrene sulfonate”

 


 

1 – The world is running out of antibiotics, WHO report confirms – World Health Organization (free)

See WHO Reports: Antibacterial Agents in Clinical Development (free) AND Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics (free)

See also WHO Resources on Antibiotic Resistance

Commentaries: WHO report paints dire picture of antibiotic development – CIDRAP (free) AND Too few antibiotics in pipeline to tackle global drug-resistance crisis, WHO warns – The Guardian (free) AND The world is running out of antibiotics, WHO says – CNN (free text and video)

 

2 – Rapid Recommendation: Corticosteroids for sore throat: a clinical practice guideline – The BMJ (free text and infographic)

See also other Rapid Recommendations from The BMJ (all free)

 

3 – Improving health systems in low-income countries – 3 New Cochrane Library Reviews

Article 1: Implementation strategies for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Implementation strategies for health systems in low-income countries (free)

Article 2: Governance arrangements for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Effects of governance arrangements for health systems in low-income countries (free)

Article 3: Delivery arrangements for health systems in low-income countries: an overview of systematic reviews (free) AND Summary: Effects of delivery arrangements for health systems in low-income countries (free)

 

4 – Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (free)

Original article: Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (link to abstract – $ for full-text)

Related: Comprehensive assessment may reduce risk of delirium after hip fracture – NIHR Signal (free)

“Older patients are more likely to be alive and in their own homes at follow-up if they received comprehensive geriatric assessment on admission to hospital”.

 

5 – Low alcohol consumption and pregnancy and childhood outcomes: time to change guidelines indicating apparently ‘safe’ levels of alcohol during pregnancy? A systematic review and meta-analyses – BMJ Open (free)

Commentaries: No change to alcohol guidelines for pregnancy – NHS Choices (free) Health risks of light drinking in pregnancy confirms that abstention is the safest approach – The Conversation (free)

 

6 – Association of spontaneous abortion with receipt of inactivated influenza vaccine containing H1N1pdm09 in 2010–11 and 2011–12 – Vaccine (link to abstract – $ for full-text)

Commentaries: Study signals association between flu vaccine, miscarriage – CIDRAP (free) AND New study finds link between flu vaccine and miscarriage. But is it real? – Science (free) AND Study shows miscarriage risk may have increased after flu shots, puzzling researchers – STAT (free) AND A new finding of a possible flu shot-miscarriage link shows science prioritizes vaccine safety – STAT (free)

“This study does not and cannot establish a causal relationship between repeated influenza vaccination and SAB, but further research is warranted”.

 

7 – Metabolically Healthy Obese and Incident Cardiovascular Disease Events Among 3.5 Million Men and Women – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: New evidence shows that healthy obesity is a myth – The Conversation (free) AND Study shows so-called ‘healthy obesity’ is harmful to cardiovascular health – Medical News Today (free) AND Obesity, even without other risk factors, leads to higher rate of cardiovascular disease – STAT (free) AND Another Study Challenges Notion of ‘Healthy Obese’ – TCTMD (free)

See related article and commentaries in our August 21st issue (see #1)

 

8 – Expert consensus document: A ‘diamond’ approach to personalized treatment of angina – Nature Reviews Cardiology (free)

 

9 – What Does the Future Hold for Scientific Journals? Visual Abstracts and Other Tools for Communicating Research – Clinics in Colon and Rectal Surgery (free)

 

10 – Effect of Axillary Dissection vs No Axillary Dissection on 10-Year Overall Survival Among Women With Invasive Breast Cancer and Sentinel Node Metastasis: The ACOSOG Z0011 (Alliance) Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Author interview: Breast Cancer Surgery: Less Is More (free audio)

Commentary: In Treating Breast Cancer, Less Can Be As Good As More – American Council on Science and Health (free)

 


 

1 – Corticosteroids in patients hospitalized with community-acquired pneumonia: systematic review and individual patient data meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)

Related Meta-analysis: Efficacy and Safety of Adjunctive Corticosteroids Therapy for Severe Community-Acquired Pneumonia in Adults: An Updated Systematic Review and Meta-Analysis – PLOS One (free) AND Efficacy and Safety of Corticosteroids for Community-Acquired Pneumonia – Chest (free) AND Adjunctive Systemic Corticosteroids for Hospitalized Community-Acquired Pneumonia: Systematic Review and Meta-Analysis 2015 Update – Scientific Reports (free)

 

2 – Summaries with 10 key points to remember of the latest European Society of Cardiology Guidelines – Latest in Cardiology, American College of Cardiology

– 2017 ESC Guidelines for the Management of STEMI (free)

– 2017 ESC/EACTS Guidelines for Management of Valvular Heart Disease (free)

– 2017 ESC Guidelines for PAD Diagnosis and Treatment (free)

– 2017 ESC Focused Update on DAPT in CAD (free)

See also our selection of the most relevant articles and commentaries from the Meeting, #ESCCongress Part I, #ESCCongress Part II and #ESCCongress Part III

 

3 – Noncommunicable Diseases Progress Monitor 2017 – World Health Organization (free)

News release: WHO launches new NCDs Progress Monitor (free)

Related WHO resources: Noncommunicable diseases: the slow-motion disaster – World Health Organization (free) AND Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors – World Health Organization (free) AND Other dimensions of the NCD crisis: from mental health, ageing, dementia and malnutrition to deaths on the roads, violence and disability (free) AND Tools for implementing WHO PEN (Package of essential noncommunicable disease interventions) (free) AND WHO’s work on NCDs (free)

 

4 – Ethics and the Legalization of Physician-Assisted Suicide: An American College of Physicians Position Paper (free)

Commentaries: ACP reaffirms opposition to physician-assisted suicide – ACP Internist (free) AND ACP Reaffirms Position Against Physician-Assisted Suicide – Physician’s First Watch (free)

 

5 – Association of Cigarette Price Differentials With Infant Mortality in 23 European Union Countries – JAMA Pediatrics (free)

Commentaries: Budget cigs linked to higher infant mortality: Stopping their sale could reduce deaths – Irish Health (free) AND The Fatal Toll of Cheap Cigarettes – The New York Times (10 articles per month are free)

 

6 – Impact of Electronic Cigarettes on the Cardiovascular System – Journal of The American Heart Association (free)

 

7 – Guideline: Contemporary Management of Cardiogenic Shock: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Top Ten Things to Know: Contemporary Management of Cardiogenic Shock (free PDF)

 

8 – Cancer’s Invasion Equation – The New Yorker (free)

We can detect tumors earlier than ever before. Can we predict whether they’re going to be dangerous?

 

9 – Medical News & Perspectives: Going With the Flow: The Promise and Challenge of Liquid Biopsies – JAMA (free)

Related: Emerging concepts in liquid biopsies – BMC Medicine (free) AND Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free)

 

10 – Use of public defibrillators linked to out-of-hospital cardiac arrest survival – NIHR Signal (free)

Original article: The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

“Each minute of delay to defibrillation is estimated to reduce the probability of long-term survival by 10%” (RT @NIHR_DC see Tweet)

 


 

1 – Report: Diet, Nutrition, Physical Activity and Colorectal Cancer – American Institute for Cancer Research (AICR) and the World Cancer Research Fund (WCRF) (Free PDF)

News release: New Report finds whole grains lower colorectal cancer risk, processed meat increases risk (free)

Infographic: Preventing Colorectal Cancer (free)

Almost half cases of colorectal cancer cases can be prevented by staying lean, eating healthy, and moving more.

 

2 – Guideline: Adolescent and Young Adult Tattooing, Piercing, and Scarification – Pediatrics (free)

Commentaries: Clinical Guidance on Body Modification Among Youth – Journal Watch (free) AND When Adolescents Want Tattoos or Piercings – The New York Times (10 articles per month are free)

 

3 – The cumulative burden of surviving childhood cancer: an initial report from the St Jude Lifetime Cohort Study (SJLIFE) – The Lancet (link to abstract – $ for full-text)

Commentaries: Survivors of Childhood Cancer Face Continuing Chronic Health Conditions – Physician’s First Watch (free) AND Severe Health Problems Plague Survivors of Childhood CA – Medscape (free registration required) AND Comprehensive Study of Chronic Disease Reveals Vulnerability of Childhood Cancer Survivors – NewsWise (free)

 

4 – Viewpoint: Nutrition Counseling in Clinical Practice: How Clinicians Can Do Better – JAMA (free)

 

5 – How alcohol industry organisations mislead the public about alcohol and cancer – Drug and Alcohol Review (free)

Commentaries: Alcohol increases cancer risk, but don’t trust the booze industry to give you the facts straight – The Conversation (free) AND Drinks industry distorts alcohol cancer risk: scientists – Reuters (free) AND Drinks industry downplaying alcohol-cancer link – The Guardian (free) AND Drinks industry accused of downplaying ‘alcohol-cancer risk’ – NHS Choices (free)

 

6 – Safety of Medical Abortion Provided Through Telemedicine Compared With in Person – Obstetrics & Gynecology (free PDF)

Commentaries: Abortion via telemedicine as safe as seeing doctor in person – Reuters (free) AND Abortion Via Telemedicine Is Totally Safe, Study Says – HuffPost (free) AND Medical Abortion Via Telemedicine Found Safe – MedPage Today (free registration required)

 

7 – The Weekend Effect in Hospitalized Patients: A Meta-Analysis – Journal of Hospital Medicine (link to abstract – free full-text PDF via @unpaywall)

Commentary: Review finds evidence for weekend effect on mortality in hospitalized patients – ACP Hospitalist (free)

Related article: Weekends affect mortality risk and chance of discharge in critically ill patients: a retrospective study in the Austrian registry for intensive care – Critical Care (free) AND Commentary: “Weekend effects” in intensive care units – On Medicine (free)

 

8 – Richard Lehman’s journal review, 18 September 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Trends in standardized mortality among individuals with schizophrenia, 1993–2012: a population-based, repeated cross-sectional study – Canadian Medical Association Journal (free)

Commentaries: Schizophrenia linked to threefold increase in death risk – Medical News Today (free) AND People with schizophrenia have threefold risk of dying – CMAJ, via EurekAlert (free)

 

10 – Strategies to reduce antibiotic prescribing for acute respiratory infections in primary care – Cochrane Library (free)

Original article: Clinician-targeted interventions to influence antibiotic prescribing behaviour for acute respiratory infections in primary care: an overview of systematic reviews – Cochrane Library (link to abstract – $ for full-text)

 


 

1 – Life, death, and disability in 2016: latest estimates from The Global Burden of Disease Study – The Lancet

Editorial: Life, death, and disability in 2016 (free)

– Global, regional, and national under-5 mortality, adult mortality, age-specific mortality, and life expectancy, 1970–2016 (free)

– Global, regional, and national age-sex specific mortality for 264 causes of death, 1980–2016 (free)

– Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016 (free)

– Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2016 (free)

– Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990–2016 (free)

– Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries (free)

Commentaries: New global study finds countries saving more lives, despite a ‘triad of troubles’ in obesity, violence, and mental illness – Institute of Health Metrics and Evaluation (free) AND Smoking And Poor Diet Still Leading Killers Worldwide – Pursuit (free)

See also: GBD Compare Interactive Tool – Explore which causes & risk factors are causing the most death & disability in your country over time (free tool)

 

2 – Guideline: Type 2 diabetes: prevention in people at high risk – National Institute for Health and Care Excellence (NICE) (free)

 

3 – Guideline: Depression in children and young people: identification and management – National Institute for Health and Care Excellence (NICE) (free)

 

4 – Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Left Main Coronary Artery Stenosis: A Systematic Review and Meta-analysis – JAMA Cardiology (free)

Commentary: CABG, PCI show similar long-term outcomes – Cardiovascular Business (free)

 

5 – Meat, Dietary Heme Iron, and Risk of Type 2 Diabetes Mellitus: The Singapore Chinese Health Study – American Journal of Epidemiology (link to abstract – $ for full-text)

Commentary: Eating meat linked to higher risk of diabetes – DukeNUS Medical School, via EurekAlert (free)

Related articles: Meat Consumption as a Risk Factor for Type 2 Diabetes – Nutrients (free) AND Meat consumption and the risk of type 2 diabetes: a systematic review and meta-analysis of cohort studies – Diabetologia (free) AND Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis – American Journal of Clinical Nutrition (free)

“The Singapore Chinese Health Study reveals increased risk of diabetes with higher intake of red meat and poultry, partially attributed to the dietary iron content in these meats” (from EurekAlert)

 

6 – How Big Business Got Brazil Hooked on Junk Food – The New York times (10 articles per month are free) (RT @glassmanamanda see Tweet)

“As growth slows in wealthy countries, Western food companies are aggressively expanding in developing nations, contributing to obesity and health problems”.

 

7 – Evaluation of a Rapid Molecular Drug-Susceptibility Test for Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Detecting Tuberculosis Resistance (free)

Commentary: New rapid molecular test for MDR-TB shows promise – CIDRAP (free)

 

8 – European guidelines on perioperative venous thromboembolism prophylaxis: Surgery in the elderly – European Journal of Anaesthesiology (free PDF)

 

9 – Effects on the incidence of cardiovascular events of the addition of pioglitazone versus sulfonylureas in patients with type 2 diabetes inadequately controlled with metformin (TOSCA.IT): a randomised, multicentre trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentary: Sulfonylureas, Pioglitazone Similarly Safe for Add-On Therapy in Type 2 Diabetes – Physician’s First Watch (free)

 

10 – Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)

 


 

1 – 2017 HIVMA of IDSA Clinical Practice Guideline for the Management of Chronic Pain in Patients Living With HIV – Clinical Infectious Diseases (free)

 

2 – Education and coronary heart disease: mendelian randomisation study – The BMJ (free)

Commentary: Going to university may cut your risk of heart disease – NHS Choices (free)

 

3 – Association Between More Intensive vs Less Intensive Blood Pressure Lowering and Risk of Mortality in Chronic Kidney Disease Stages 3 to 5: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Intensive blood pressure lowering linked to decreased mortality in patients with chronic kidney disease – 2 Minute Medicine (free) AND Intensive BP Lowering in Chronic Kidney Disease Associated with Lower Mortality – Physician’s First Watch (free) AND Is Strict BP Control a Good Bet for CKD Patients? – MedPage Today (free registration required)

 

4 – Pathophysiology, diagnosis and treatment of tachycardiomyopathy – Heart (free)

Source: Critical Care Review Newsletter

 

5 – Corticosteroid or Nonsteroidal Antiinflammatory Drugs for the Treatment of Acute Gout: A Systematic Review of Randomized Controlled Trials – The Journal of Rheumatology (free)

Source: EvidenceAlerts

Corticosteroids and NSAIDs did not have different effects on pain scores, but there was a higher risk of indigestion, nausea and vomiting with NSAIDs.

 

6 – New Series: The World Bank and financing global health – The BMJ

– World Bank’s financing, priorities, and lending structures for global health (free)

– Universal health coverage, health systems strengthening, and the World Bank (free)

– World Bank and the Global Financing Facility (free)

– Earmarking for global health: benefits and perils of the World Bank’s trust fund model (free)

– Health as a “global public good”: creating a market for pandemic risk (free)

– Baines and Babar: Why medical practitioners should be interested in the World Bank (free)

 

7 – The effects of improving sleep on mental health (OASIS): a randomised controlled trial with mediation analysis – The Lancet (free)

Commentaries: Sleep improvement by internet-based cognitive behavioural therapy might help prevent mental health disorders – The Lancet (free) AND Lack of sleep could contribute to mental health problems, researchers reveal – The Guardian (free) AND Tackling insomnia may be key to easing mental health issues – OnMedica (free)

 

8 – Protocol for the management of psychiatric patients with psychomotor agitation – BMC Psychiatry (free)

 

9 – A range of anti-epilepsy drugs are effective as first-line treatment – NIHR Signal (free)

Original article: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data – Cochrane Library (link to abstract – $ for full-text)

 

10 – Osteoporosis drug treatment: duration and management after discontinuation. A position statement from the SVGO/ASCO – Swiss Medical Weekly (free)

 


 

1 – Measuring progress and projecting attainment on the basis of past trends of the health-related Sustainable Development Goals in 188 countries: an analysis from the Global Burden of Disease Study 2016 – The Lancet (free)

Commentary: IHME releases second annual report on the Sustainable Development Goal indicators – Institute for Health Metrics and Evaluation (free)

See also: Health-related Sustainable Development Goals visualization tool, which allows users to compare and contrast between countries and among indicators, and the United Nations Sustainable Development Goals Website.

 

2 – Guideline: Prevention of Early-onset Neonatal Group B Streptococcal Disease – Royal College of Obstetricians and Gynaecologists (free)

News release: Group B Streptococcal Disease, Early-onset (free)

Commentaries: Antibiotics for women in early labour to combat Group B Strep – OnMedica (free) AND More pregnant women to get Group B Strep treatment – BBC News (free)

 

3 – Review article: Randomized, Controlled Trials in Health Insurance Systems – New England Journal of Medicine (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

 

4 – Benefit of Patent Foramen Ovale Closure Seen in Selected Patients with Cryptogenic Stroke – Journal Watch (free)

Original articles from the New England Journal of Medicine: Patent Foramen Ovale Closure or Antiplatelet Therapy for Cryptogenic Stroke (link to abstract – $ for full-text) AND Patent Foramen Ovale Closure or Anticoagulation vs. Antiplatelets after Stroke (link to abstract – $ for full-text) AND Long-Term Outcomes of Patent Foramen Ovale Closure or Medical Therapy after Stroke (link to abstract – $ for full-text)

 

5 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Treatment of Colon Cancer (free)

 

6 – Prevention of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline (free)

 

7 – European Respiratory Society guidelines for the management of adult bronchiectasis (free)

 

8 – Risk of relapse after antidepressant discontinuation in anxiety disorders, obsessive-compulsive disorder, and post-traumatic stress disorder: systematic review and meta-analysis of relapse prevention trials – The BMJ (free)

Commentary: Researchers: Antidepressants for Anxiety Should Be Continued for at Least a Year After Treatment Response – Physician’s First Watch (free)

 

9 – Association Between Laparoscopic Antireflux Surgery and Recurrence of Gastroesophageal Reflux – JAMA (link to abstract – $ for full-text)

Commentaries: Laparoscopic Antireflux Surgery Associated With High Rate of Recurrence of GERD – The JAMA Network (free) AND GERD Recurrence Fairly Common Following Laparoscopic Antireflux Surgery – Physician’s First Watch (free) AND High recurrence of gastroesophageal reflux disease in patients treated with laparoscopic antireflux surgery – 2 Minute Medicine (free)

 

10 – Differential blood pressure effects of ibuprofen, naproxen, and celecoxib in patients with arthritis: the PRECISION-ABPM (Prospective Randomized Evaluation of Celecoxib Integrated Safety Versus Ibuprofen or Naproxen Ambulatory Blood Pressure Measurement) Trial – European Heart Journal (free)

Commentaries: Under Pressure: PRECISION Substudy Shows Adverse BP Effects of Ibuprofen – TCTMD (free) AND Increases in BP, Hypertension Incidence Linked to Certain NSAIDs – MPR (free) AND Ibuprofen Ups Systolic BP, New-Onset Hypertension Risk – Medscape (free registration required)

 


 

1 – International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) (RT @CritCareReviews see Tweet)

 

2 – Report: Preventing noncommunicable diseases (NCDs) by reducing environmental risk factors – World Health Organization (free)

We welcome new @WHO report, showing 23% of all deaths can be prevented through healthier environments” (RT @HealthandEnv see Tweet)

 

3 – Draft Recommendation Statement: Cervical Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Draft Recommendation Eliminates Cervical Cytology-HPV Cotesting for Women Over 30 – Physician’s First Watch (free) AND USPSTF: Pap Test or HPV Test, Not Both, For Most Cervical Ca Screening – MedPage Today (free registration required) AND USPSTF Has New Draft Guidance for Cervical Cancer Screening – Medscape (free registration required) AND Age matters when it comes to screening for cervical câncer – STAT (free)

 

4 – Research and Development Spending to Bring a Single Cancer Drug to Market and Revenues After Approval – JAMA Internal Medicine (free)

Author interview: Cost of Developing a Single Cancer Drug (free audio)

Invited commentary: A Much-Needed Corrective on Drug Development Costs (free)

Commentaries: R&D Costs For Cancer Drugs Are Likely Much Less Than Industry Claims, Study Finds – NPR (free) AND A new study undermines Big Pharma’s justification for charging high drug prices – Business Insider (free) AND What Does It Cost to Create a Cancer Drug? Less Than You’d Think – The New York Times (10 articles per month are free)

 

5 – Antiretroviral therapy in pregnant women living with HIV: a clinical practice guideline – The BMJ (free guideline and infographic)

 

6 – Menopausal Hormone Therapy and Long-term All-Cause and Cause-Specific Mortality: The Women’s Health Initiative Randomized Trials – JAMA (link to abstract – $ for full-text)

Commentaries: Taking Hormones for Menopause Doesn’t Raise Early Death Risk – The New York Times (free) AND Menopause hormone therapy not linked to premature death – Reuters (free) AND Menopause hormones don’t shorten lives, long follow-up says – STAT (free)

 

7 – Patient-Clinician Communication: American Society of Clinical Oncology Consensus Guideline (free)

News release: New Guideline Aims to Improve Clinician Communication With Patients (free)

 

8 – Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (free)

Original article: Laparoscopic and robotic-assisted versus open radical prostatectomy for the treatment of localised prostate cancer – Cochrane Library (link to abstract – $ for full-text)

“Urinary and sexual quality of life-related outcomes appear similar”.

 

9 – LDL-Cholesterol Lowering for the Primary Prevention of Cardiovascular Disease Among Men with Primary Elevations of LDL-Cholesterol Levels of 190 mg/dL or Above: Analyses from the WOSCOPS 5-year Randomised Trial and 20-year Observational Follow-Up – Circulation (free)

Commentary: Statins cut heart deaths in men by 28% finds study – NHS Choices (free)

 

10 – Role of Total, Red, Processed, and White Meat Consumption in Stroke Incidence and Mortality: A Systematic Review and Meta‐Analysis of Prospective Cohort Studies – Journal of The American Heart Association (free)

Increased consumption of red and processed meat may be associated with higher risk of stroke.

 


 

1 – Treatment of Type 1 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes – Annals of Internal Medicine (free)

 

2 – Recommendations on screening for abdominal aortic aneurysm in primary care – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers (free) AND Abdominal Aortic Aneurysm (AAA): 1000-Person Tool (free)

“The number of men >65 needed to screen to prevent one AAA related death is 796 (95% confidence interval 621–1242) @ 3-5 yr follow-up” (RT @cantaskforce see Tweet)

  

3 – Clinical Practice Guideline: Evaluation of the Neck Mass in Adults – American Academy of Otolaryngology—Head and Neck Surgery Foundation (free)

See also: Executive Summary (free) AND News Release (free)

Commentaries: Neck Mass in Adults: Guideline for Evaluation Provides Framework for Timely Diagnosis – NewsWise (free) AND Guidelines Issued on Evaluating Neck Masses – Physician’s First Watch (free)

 

4 – A Comparison of Alkaline Water and Mediterranean Diet vs Proton Pump Inhibition for Treatment of Laryngopharyngeal Reflux – JAMA Otolaryngology Head Neck Surgery (free)

Commentaries: Could a Mediterranean diet be as good as drugs for acid reflux? – NHS Choices (free) AND Dietary Approach Found as Effective as Medications for Treating Type of Reflux Disease – The JAMA Network (free) AND Treating Reflux With Diet – The New York Times (10 articles per month are free)

A small retrospective cohort study suggests a plant-based, Mediterranean-style diet may be as effective as medication.

 

5 – The Joint Associations of Sedentary Time and Physical Activity With Mobility Disability in Older People: The NIH-AARP Diet and Health Study – The Journals of Gerontology (free)

Commentaries: Get Off The Couch Baby Boomers, Or You May Not Be Able To Later – NPR (free) AND Prospective Study Shows Just How Bad TV Can Be – Medscape (free registration required) AND Prolonged sitting and TV watching ‘dangerous’ for seniors – Medical News Today (free) AND TV viewing ‘a potent risk factor’ for disability – OnMedica (free)

 

6 – Guideline: National Partnership for Maternal Safety: Consensus Bundle on Severe Hypertension During Pregnancy and the Postpartum Period – Obstetrics & Gynecology (free)

Commentary: Management of Severe Maternal Hypertension During Pregnancy and Postpartum – Journal Watch (free)

 

7 – Hormonal contraceptive eligibility for women at high risk of HIV: Guidance Statement – World Health Organization (free PDF)

News release: Can women who are at high risk of acquiring HIV, safely use hormonal contraception? (free)

Frequently asked questions: Hormonal contraceptive eligibility for women at high risk of HIV (free)

Guideline Summary: Hormonal contraceptive eligibility for women at high risk of HIV: guidance statement – National Guideline Clearinghouse (free)

 

8 – Cardiovascular disease risk and androgen deprivation therapy in patients with localised prostate cancer: a prospective cohort study – British Journal of Cancer (link to abstract – $ for full-text)

Commentaries: Prostate cancer treatment associated with higher risk of heart failure – Cardiovascular Business (free) AND Hormone Treatment for Prostate Cancer Tied to Heart Risks – The New York Times (10 articles per month are free)

 

9 – Richard Lehman’s journal review, 11 September 2017 (free)

Richard Lehman reviews the latest research in the top medical journals.

 

10 – Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free)

 


 

1 – Coursera – Free Online Health & Medicine Courses Starting Today!

– Easing the burden of obesity, diabetes and cardiovascular disease – University of Sidney

– Leading Healthcare Quality and Safety – The George Washington University

– Introduction to the Biology of Cancer – Johns Hopkins University

– Understanding Clinical Research: Behind the Statistics – University of Cape Town

– Health Across the Gender Spectrum – Stanford University

– Public Health in Humanitarian Crises – Johns Hopkins University

– Major Depression in the Population: A Public Health Approach – Johns Hopkins University

– Genomics: Decoding the Universal Language of Life – University of Illinois at Urbana-Champaign

– Living with Dementia: Impact on Individuals, Caregivers, Communities and Societies – Johns Hopkins University

– Health Care IT: Challenges and Opportunities – Icahn School of Medicine at Mount Sinai

– The People, Power, and Pride of Public Health – Johns Hopkins University

– The Science of Health Care Delivery – Arizona State University

– PrEParing: PrEP for Providers and Patients – Johns Hopkins University

 

2 – Management of Cardiac Involvement Associated With Neuromuscular Diseases: A Scientific Statement From the American Heart Association (free PDF)

News release: Experts aim to improve treatment for heart complications in people with neuromuscular disorders (free)

Top Ten Things to Know: Management of Cardiac Involvement Associated With Neuromuscular Diseases (free PDF)

Commentary: Statement on the Management of Cardiac Involvement Associated With Neuromuscular Diseases – Practice Update (free registration required)

 

3 – Comprehensive primary prevention of cardiovascular disease in women – Clinical Cardiology (free)

 

4 – Opinion: Cardiology Is Dead. Long Live Public Health – Cardiobrief (free)

 

5 – 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required)

Related: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND Patient often prescribed potentially futile drugs in their final months of life – Science Daily AND The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF) Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)

 

6 – Educating Girls, Ending Child Marriage – World Bank (free)

Related infographic and report: Putting a Price Tag on Child Marriage

“By keeping girls in school, girls would have a better chance for safety and security, to health and education, and to make their own life choices and decisions”.

“Being born to a mother younger than 18 increases the risk dying by the age of 5” (RT @WBG_Health see Tweet)

 

7 – Guidance on Forgoing Life-Sustaining Medical Treatment – Pediatrics (free)

News Release: Balancing act: Weighing the decision to withhold life-sustaining medical treatment (free)

 

8 – Palliative Care in Heart Failure: The PAL-HF Randomized, Controlled Clinical Trial – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Palliative Care Intervention Improves Quality of Life in Advanced Heart Failure Patients – American College of Cardiology, Latest in Cardiology (free) AND Palliative Care & CHF: PAL-HF trial – Pallimed (free)

 

9 – Development and risk factors of type 2 diabetes in a nationwide population of women with polycystic ovary syndrome – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)

Commentaries: Type 2 diabetes risk four times higher in women with PCOS – Medical News Today (free) AND Researchers reveal link between PCOS, type 2 diabetes – The Endocrine Society, via EurekAlert (free)

 

10 – Addressing the Social Needs of Hypertensive Patients: The Role of Patient–Provider Communication as a Predictor of Medication Adherence – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Hypertension Medication Adherence May Be Improved by Collaborate Communication – Cardiology Advisor (free) AND Better Provider Communication Might Improve Medication Adherence – Medscape (free registration required) AND Talk Why, Not What for Better Antihypertensive Adherence – MedPage Today (free)

“Odds of poor med adherence 6x greater when patient-provider interactions don’t address patients’ unmet social needs” (RT @CircOutcomes see Tweet)

 


 

1 – Defining Optimal Brain Health in Adults: A Presidential Advisory From the American Heart Association/American Stroke Association (free)

See also: Advisory Highlights: Seven steps to keep your brain healthy from childhood to old age (free) AND News release: As brain problems increase, experts offer advice to keep yours healthy (free) AND Commentary: Optimal Cardiovascular Health and a Healthy Brain (free) AND Top Ten Things to Know: Defining Optimal Brain Health in Adults (free PDF)

Commentary: Heart and Stroke Groups Issue Advisory on Optimal Brain Health – Physician’s First Watch (free)

  

2 – Everybody active, every day: an evidence-based approach to physical activity – Public Health England (free report and other documents)

See also: 10 minutes brisk walking each day in mid-life for health benefits and towards achieving physical activity recommendations: evidence summary (free PDF)

Press release: 6 million adults do not do a monthly brisk 10-minute walk (free)

Commentaries: 10-minute walk a day app to tackle ‘inactivity epidemic’ – NHS Choices (free) AND 6 million middle-aged people take no exercise – The Guardian (free)

 

3 – Report: Size matters: The impact of upselling on weight gain – Royal Society for Public Health; Slimming World (free PDF)

See also: Press release (free)

Commentaries: Supersize us: upselling is fuelling the obesity epidemic, warns report – The Guardian (free) AND Going Large – Is Upselling Making You Gain Weight? – Medscape (free registration required)

 

4 – Extreme high high-density lipoprotein cholesterol is paradoxically associated with high mortality in men and women: two prospective cohort studies – European Heart Journal (free)

Commentaries: High levels of ‘good’ cholesterol linked to excessive mortality – University of Copenhagen, via ScienceDaily (free) AND Does ‘good cholesterol’ really deserve its name? – The Conversation (free) AND Can Your “Good” Cholesteral Be To High? – The New York Times (10 articles per month are free)

 

5 – Antipsychotic Use With and Without Comorbid Psychiatric Diagnosis Among Adults with Intellectual and Developmental Disabilities – The Canadian Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Antipsychotics common for adults with intellectual and developmental disabilities – Centre for Addiction and Mental Health (free) AND Antipsychotics Overused in Intellectually Disabled Adults – Medscape (free registration required)

“Antipsychotics are used inappropriately particularly in vulnerable groups: Poor children; Intellectually challenged; Autistic; Nursing homes. (RT @AllenFrancesMD see Tweet)

 

6 – Safety and Feasibility of Antiretroviral Preexposure Prophylaxis for Adolescent Men Who Have Sex With Men Aged 15 to 17 Years in the United States – JAMA Pediatrics (free)

Editorial: Human Immunodeficiency Virus Preexposure Prophylaxis for Adolescent Men (free)

Commentaries: Safety, Feasibility of PrEP for Adolescent Men Who Have Sex With Men – The JAMA Network (free) AND PrEP safe and effective for young men who have sex with men – OnMedica (free) AND HIV PrEP for adolescent men found to be safe, effective – UPI (free)

 

7 – Potential Implications of NORSTENT (Norwegian Coronary Stent Trial) in Contemporary Practice – Circulation (free)

Original article: Drug-Eluting or Bare-Metal Stents for Coronary Artery Disease – New England Journal of Medicine (free)

In this large trial, differences in outcomes between bare metal stents (BMS) and drug eluding stents (DES) were small. During 6 years of follow-up there was a 3.3% absolute risk reduction in any repeat revascularization with DES, without differences in cardiovascular mortality or death.

 

8 – Chronic Health Conditions and Key Health Indicators Among Lesbian, Gay, and Bisexual Older US Adults, 2013–2014 – American Journal of Public Health (link to abstract – $ for full-text)

Commentaries: Lesbian, Gay and Bisexual Older Adults Suffer More Chronic Health Conditions Than Heterosexuals, Study Finds – The University of Washington, via NewsWise (free) AND LGB Older Adults Suffer More Chronic Health Conditions Than Heterosexuals, Study Finds – Science Magazine (free)

 

9 – IBM pitched its Watson supercomputer as a revolution in cancer care. It’s nowhere close – STAT (free)

 

10 – Intravenous Versus Nonintravenous Benzodiazepines for the Cessation of Seizures: A Systematic Review and Meta-analysis of Randomized Controlled Trials – Academic Emergency Medicine (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club

 “Should you give your preferred benzo by the fastest means possible? Or establish an IV and administer via that route? The short answer provided by this study, is to give your benzo IM or IN. While seizures stopped sooner after IV administration, the additional time needed to establish an IV resulted in overall longer seizure time when administered via that method” (by Jeremy Fried in Research and Reviews in the Fastlane 182).

 


 

1 – Guideline: Endometriosis: diagnosis and management – National Institute for Health and Care Excellence (NICE) (free)

News release: Suspect endometriosis in women with chronic pelvic pain, says NICE (free)

 

2 – Vision Screening in Children Aged 6 Months to 5 Years: US Preventive Services Task Force Recommendation Statement – JAMA (free)

USPSTF Recommendation Summary: Vision in Children Ages 6 Months to 5 Years: Screening (free)

Editorials: The 2017 US Preventive Services Task Force Report on Preschool Vision Screening – JAMA Ophthalmology (free) AND Vision Screening in Very Young Children—Making Sense of an Inexorable Diagnostic Process – JAMA Pediatrics (free)

Author interview: USPSTF Recommendation: Vision Screening in Children (free audio)

 

3 – Antidepressant use during pregnancy and psychiatric disorders in offspring: Danish nationwide register based cohort study – The BMJ (free)

Editorial: Prenatal exposure to antidepressants and increased risk of psychiatric disorders (free)

Commentary: Antidepressant Use During Pregnancy Linked to Psychiatric Disorders in Offspring – Physician’s First Watch (free)

 

4 – Treatment of idiopathic pulmonary fibrosis in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia (free)

 

5 – European Stroke Organization guideline for the diagnosis and treatment of cerebral venous thrombosis – endorsed by the European Academy of Neurology (free)

 

6 – Effectiveness of a Third Dose of MMR Vaccine for Mumps Outbreak Control – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Third Dose of MMR Vaccine to Reduce Risk of Mumps during Outbreaks? (free)

Commentary: Third dose of mumps vaccine could help stop outbreaks, researchers say – STAT (free)

 

7 – State of The Art Review: Perioperative tobacco use treatments: putting them into practice – The BMJ (free for 2 weeks)

 

8 – Review: The Diagnosis and Management of Bipolar I and II Disorders – Mayo Clinic Proceedings (free)

 

9 – Global Prevalence of Fetal Alcohol Spectrum Disorder Among Children and Youth: A Systematic Review and Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)

Commentary: What Is the Global Prevalence of Fetal Alcohol Spectrum Disorder? – The JAMA Network (free)

 

10 – 2017 Focused Update of the 2016 ACC Expert Consensus Decision Pathway on the Role of Non-Statin Therapies for LDL-Cholesterol Lowering in the Management of Atherosclerotic Cardiovascular Disease Risk (free)

Commentary: Updated Decision Pathway For Non-Statin Therapies Published – American College of Cardiology, Latest in Cardiology (free)

 


 

1 – Estimated economic impact of vaccinations in 73 low- and middle-income countries, 2001–2020 – Bulletin of the World Health Organization (free) (RT @Onisillos see Tweet)

Commentaries: Vaccines Save 20 Million Lives, $350 billion in Poor Countries since 2001 – Eshelman School of Pharmacy (free) AND Global vaccine program will save 20 million lives and $820 billion by 2020, research finds – International Business Times (free)

 

2 – Ranking 93 health interventions for low- and middle-income countries by cost-effectiveness – PLOS One (free) (RT @equitylist see Tweet)

 

3 – Effect of Palliative Care on Aggressiveness of End-of-Life Care Among Patients With Advanced Cancer – Journal of Oncology Practice (link to abstract – $ for full-text)

Commentaries: Palliative Care May Substantially Decrease Health-Care Utilization in Patients With Advanced Cancer – ASCO Post (free) AND End-of-Life Palliative Care Lowered Utilization for Patients With Cancer – AJMC (free) AND Palliative Care Cut Healthcare Use in Advanced Cancer – MedPage Today (free registration required)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

4 – Doctors want to give their cancer patients every chance. But are they pushing off hard talks too long? – STAT (free)

 

5 – Committee Opinion: Obesity in Adolescents – American College of Obstetricians and Gynecologists (free)

Commentary: ACOG Offers Tips for Managing Obesity in Adolescents – Physician’s First Watch (free)

 

6 – Can low doses of chemicals affect your health? A new report weighs the evidence – The Conversation (free)

Original report: Application of Systematic Review Methods in an Overall Strategy for Evaluating Low-Dose Toxicity from Endocrine Active Chemicals – The National Academies Press (free PDF)

Related Scientific Statement: EDC-2: The Endocrine Society’s Second Scientific Statement on Endocrine-Disrupting Chemicals (free) AND Executive Summary (free)

Source: Global Health NOW Newsletter

 

7 – Richard Lehman’s journal review / 4 September 2017 (free)

Richard Lehman’s weekly review of medical journals.

 

8 – Zika virus: still no clear answers – The Globe and Mail (free) (RT @Onisillos  see Tweet)

 

9 – Self‐Care for the Prevention and Management of Cardiovascular Disease and Stroke: A Scientific Statement for Healthcare Professionals From the American Heart Association (free)

 

10 – Comparative Effectiveness and Safety of Cognitive Behavioral Therapy and Pharmacotherapy for Childhood Anxiety Disorders: A Systematic Review and Meta-analysis – JAMA Pediatrics (free)

Editorial: Medication and Cognitive Behavioral Therapy for Pediatric Anxiety Disorders: No Need for Anxiety in Treating Anxiety (free)

Commentary: SSRIs, Cognitive-Behavioral Therapy Effective for Childhood Anxiety – Physician’s First Watch (free) AND SSRIs, SNRIs Provide Modest Benefit to Kids with Mental Disorders – MedPage Today (free registration required)

 


 

1 – Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers – The Commonwealth fund (free)

Related: Redesigning Care for High-Cost, High-Risk Patients – Harvard Business Review (a few articles per month are free) AND Caring for High-Need, High-Cost Patients — An Urgent Priority – New England Journal of Medicine (free) AND Multimorbidity: clinical assessment and management – NICE Guideline (free) AND Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology (free) AND Focusing on High-Cost Patients — The Key to Addressing High Costs? – NEJM Catalyst (free) AND Richard Smith: The challenge of high need, high cost patients – The BMJ Blogs (free) AND Playbook: Better Care for People with Complex Needs – Institute for Healthcare Improvement (free)

 

2 – Reconciling the Effects of Screening on Prostate Cancer Mortality in the ERSPC and PLCO Trials – Annals of Internal Medicine (free)

Editorial: Prostate Cancer Screening: Time to Question How to Optimize the Ratio of Benefits and Harms (free)

Commentaries: A new study claims prostate cancer screenings significantly reduce deaths. Not everyone agrees – STAT (free) AND New Study Offers Support for Prostate Testing – The New York Times (10 articles per month are free)

 

3 – Scanning The Future, Radiologists See Their Jobs At Risk – NPR (free)

See more on the impact of artificial intelligence in healthcare in our June 14th issue (see #2), in our April 28th issue (see #1) and in our April 10th issue (see #8).

 

4 – Identifying incipient dementia individuals using machine learning and amyloid imaging – Neurobiology of Aging (free)

Commentaries: A.I., Big Data Project Predicts Dementia 2 Years Before Symptoms Onset, Researchers Show – Alzheimer’s News Today (free) AND Artificial intelligence predicts dementia before onset of symptoms – Science Daily (free)

See also related article and commentaries on Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons.

 

5 – Management of Atherosclerotic Carotid and Vertebral Artery Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS) (free)

Commentary with highlights from the document: European Society for Vascular Surgery Guidelines on the Management of Atherosclerotic Carotid and Vertebral Artery Disease (free)

 

6 – Diagnosis and empirical treatment of fever of unknown origin (FUO) in adult neutropenic patients: guidelines of the Infectious Diseases Working Party (AGIHO) of the German Society of Hematology and Medical Oncology (DGHO) (free)

Related Guidelines: Management of febrile neutropaenia: ESMO Clinical Practice Guidelines (free) AND Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)

 

7 – Headache and migraine: interventions for preventing or treating headache and migraine – Cochrane Library (free) (RT @CochraneUK see Tweet)

Migraine awareness week (3-9 September). Latest Cochrane Evidence on interventions for preventing or treating headache and migraine.

 

8 – Comprehensive assessment may reduce risk of delirium after hip fracture – NIHR Signal (free)

Original article: Comprehensive Geriatric Assessment for Prevention of Delirium After Hip Fracture: A Systematic Review of Randomized Controlled Trials – Journal of The American Geriatrics society (link to abstract – $ for full-text)

“Comprehensive geriatric assessment reduced the risk of delirium by 20% in patients having hip fracture surgery” (RT @NIHR_DC see Tweet)

 

9 – Physical Activity Frequency and the Risk of Stroke: A Nationwide Cohort Study in Korea – Journal of The American Heart Association (free)

“Even 1 to 2 times a week of moderate to vigorousintensity physical activity might be beneficial to prevent a firstever stroke in the general population… from a public health perspective, we need to encourage inactive people to start exercising with moreachievable goals”.

 

10 – Association between sedentary time and mortality across levels of frailty – Canadian Medical Association Journal (free)

Commentary: Prolonged sitting and frailty a deadly combination – Medical News Today (free) AND Inactivity Toll Worst for Frailest Elders – Medscape (free registration required)

 


 

1 – Reducing the Global Burden of Cardiovascular Disease, Part 1: The Epidemiology and Risk Factors – Circulation Research (free)

 

2 – Reducing the Global Burden of Cardiovascular Disease, Part 2: Prevention and Treatment of Cardiovascular Disease – Circulation Research (free)

 

3 – Official ERS/ATS clinical practice guidelines: noninvasive ventilation for acute respiratory failure (free)

Source: Hospital Medicine Virtual Journal Club

 

4 – Review: Mechanical Ventilation: State of the Art – Mayo Clinic Proceedings (free)

 

5 – Guideline: Psoriasis: assessment and management – National Institute for Health and Care Excellence (NICE) (free)

 

6 – FDA News Release: FDA approval brings first gene therapy to the United States (free)

Commentaries: A $475,000 cancer drug: Wall Street sees ‘bargain’; patients see ‘completely broken’ system – HealthNewsReview (free) FDA Approves First CAR-T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia – National Institutes of Health (free) AND FDA Approves First Gene-Altering Leukemia Treatment, Costing $475.000 – New York Times (10 articles per month are free) AND The FDA Approves a Landmark Cancer Drug – The Atlantic (free)

“…is a cancer therapy that represents several things at once: a game-changing way to treat cancer through genetic engineering, a novel paradigm for the biotech business, and the latest turn in the debate over just how astronomically expensive a life-saving therapy can be”. (from The Atlantic)

 

7 – ACC/AATS/AHA/ASE/ASNC/HRS/SCAI/SCCT/SCMR/STS 2017 Appropriate Use Criteria for Multimodality Imaging in Valvular Heart Disease (free)

Commentary with highlights from the document: Appropriate Use Criteria Published for Valvular Heart Disease Imaging Tests – American College of Cardiology, Latest in Cardiology (free)

 

8 – Accelerometer-assessed sedentary work, leisure time and cardio-metabolic biomarkers during one year: Effectiveness of a cluster randomized controlled trial in parents with a sedentary occupation and young children – PLOS One (free)

Commentaries: Sitting for 20 minutes less a day won’t make you ‘more muscly’ – NHS Choices (free) AND Just 21 minutes less sitting improves health – Medical News Today (free)

 

9 – New Nutrition Study Changes Nothing – The Atlantic (free) (RT @drjohnm see Tweet)

See original article and commentaries in our August 30 issue (see #1 and #2)

“Why the science of healthy eating appears confusing – but isn’t”

 

10 – Molluscum contagiosum is best left to clear by itself – NIHR Signal (free)

Original article: Interventions for cutaneous molluscum contagiosum – Cochrane Library (link to abstract – $ for full-text)

“Clinicians should advise people with a healthy immune system to leave molluscum contagiosum to clear by itself” (RT @NIHR_DC  see Tweet)

 


 

1 – Public Health Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (NICE) (free)

“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk”

 

2 – Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)

Commentary: Heart Failure with Preserved Ejection Fraction: Treatments Compared – MPR (free)

Source: ACP Journal Wise ($)

This study suggests a reduction in all-cause mortality with beta-blocker therapy in patients with heart failure with preserved ejection fraction. The authors recommend further trials to confirm the benefits of beta-blockers in this patient group.

 

3 – Drug-Free Interventions to Reduce Pain or Opioid Consumption After Total Knee Arthroplasty: A Systematic Review and Meta-analysis – JAMA Surgery (free)

Commentaries: Acupuncture, Electrotherapy after Knee Replacement Associated with Reduced and Delayed Opioid Use – The JAMA Network (free) AND Electrotherapy, Acupuncture Tied to Less Opioid Use After Knee Arthroscopy – Medscape (free registration required) AND Meta-Analysis: Electrotherapy, Acupuncture May Help Reduce Opioid Use After Knee Arthroplasty – Physician’s First Watch (free)

 

4 – Original articles: Cost-Effectiveness of Intensive versus Standard Blood-Pressure Control – New England Journal of Medicine (link to abstract – $ for full-text) AND Effect of Intensive Blood-Pressure Treatment on Patient-Reported Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Analyses from SPRINT examine cost-effectiveness, patient-reported outcomes with intensive BP control – ACP Internist (free) AND Intensive BP Management Well Tolerated, Cost-effective: SPRINT – Medscape (free registration required) AND Can SPRINT Be Used To Inform Hypertension Treatment? – Cardiobrief (free)

Be sure to measure the patient’s blood pressure in the same way it was done in the SPRINT trial before adopting this study results in clinical practice (see Cardiobrief commentary)

 

5 – Natural History and Tumor Volume Kinetics of Papillary Thyroid Cancers During Active Surveillance – JAMA Otolaryngology Head & Neck Surgery (free for a week)

Author interview: Natural History and Tumor Volume Kinetics of Papillary Thyroid Cancers (free audio)

Commentaries: Findings Support Use of Active Surveillance for Low-Risk Papillary Thyroid Cancer – The JAMA Network (free) AND Many People Can Delay Treatment For Thyroid Cancer, Study Finds – NPR (free)

 

6 – How should we deal with non-culprit lesions during a STEMI? A mid-night conundrum – Evidently Cochrane (free)

Original article: Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (link to abstract – $ for full-text)

 

7 – Preventing Teen Suicide: What Does the Evidence Shows – The New York Times (10 articles per month are free)

Related Guideline: Preventing Suicide: A Technical Package of Policy, Programs, and Practices – Centers for Disease Control and Prevention (free PDF)

 

8 – Low molecular weight heparin for prevention of venous thromboembolism in patients with lower-limb immobilization – Cochrane Library (link to abstract – $ for full-text)

“Moderate-quality evidence showed that the use of LMWH in outpatients reduced DVT when immobilization of the lower limb was required, when compared with no prophylaxis or placebo”. 

 

9 – Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006) – The Lancet (link to abstract – $ for full-text)

Commentary: Pembrolizumab Prolongs Overall Survival Compared With Ipilimumab in Melanoma – Cancer Therapy Advisor (free)

Source: Richard Lehman’s journal review (free)

 

10 – Impact of Obesity on Intensive Care Unit Resource Utilization After Cardiac Operations – The Annals of Thoracic Surgery (link to abstract – $ for full-text)

Commentaries: Obese cardiac patients a drain on ICU resources – Cardiovascular Business (free) AND Obese Cardiac Surgery Patients a Burden on ICU Resources – TCTMD (free) AND Post–Cardiac Surgery ICU Usage Rises With Increasing Obesity – Medscape (free registration required)

 


 

1 – Comparison of recommendations for screening mammography using CISNET models – Cancer (link to abstract – $ for full-text)

Commentaries: Three questions to ask about calls to widen breast cancer screening – The Conversation (free) AND Comparison of Screening Recommendations for Mammography – ASCO Post (free)

Canadian Task Force on Preventive Health Care: Risks & Benefits, Age 40–49 (free) AND Risks & Benefits, Age 50–69 (free) AND Risks & Benefits, Age 70–74 (free) AND Full Guideline and Resources (free)

This article had a lot of attention from the media and suggests an annual screening starting at age 40 would prevent more breast cancer deaths. But screening has potential harms. For a clearer picture of the benefits and harms of screening in this context have a look at The Conversation commentary above and the infographics from the Canadian Task Force.

 

2 – History of breast feeding and risk of incident endometriosis: prospective cohort study – The BMJ (free)

Commentaries: Breast-Feeding Associated with Reduced Endometriosis Risk – Physician’s First Watch (free) AND Breast-Feeding May Lower Risk of Endometriosis – The New York Times (10 articles per month are free)

 

3 – Sleep architecture and the risk of incident dementia in the community – Neurology (link to abstract – $ for full-text)

Commentaries: Lack of REM sleep may lead to higher risk for dementia – Boston University School of Medicine, via EurekAlert (free) AND Less REM Sleep May Significantly Boost Dementia Risk – Medscape (free registration required) AND Dreaming may keep dementia at bay – Medical News Today (free) AND Lack of REM sleep tied to increased risk of dementia – Reuters (free)

 

4 – Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Breathing Disorders During Sleep Tied to Cognitive Issues – MedPage Today (free registration required) AND Sleep-Disordered Breathing Raises Risk for Cognitive Decline – Medscape (free registration required)

This meta-analysis of observational studies suggests a possible association. Further studies are needed to examine whether the treatment of this condition can help in the prevention of dementia and in improvement of cognition.

 

5 – Chest CT Signs in Pulmonary Disease: A Pictorial Review – Chest (free)

Source: Critical Care Review Newsletter (free)

 

6 – Viewpoint: Management of Parkinson Disease in 2017: Personalized Approaches for Patient-Specific Needs – JAMA (free)

 

7 – Chronic cough postacute respiratory illness in children: a cohort study – Archives of Disease in Childhood (link to abstract – $ for full-text)

Commentary: Kids often have a chronic cough after respiratory illness – Reuters (free)

 

8 – Medical News & Perspectives: Medical Students Fall Short on Blood Pressure Check Challenge – JAMA (free)

Original Article: Medical students and measuring blood pressure: Results from the American Medical Association Blood Pressure Check Challenge – The Journal of Clinical Hypertension (free)

“Only 1 out of 159 medical students correctly performed all 11 elements in a BP check challenge w simulated patients” (RT @JAMA_current see Tweet)

 

9 – #ESCCongress – Clopidogrel or ticagrelor in acute coronary syndrome patients treated with newer-generation drug-eluting stents: CHANGE DAPT – EuroIntervention (link to abstract – $ for full-text)

Commentaries: Rethinking dual antiplatelet guidelines in acute coronary syndrome? (CHANGE-DAPT) – ESC Press Releases (free) AND Ticagrelor for DAPT Again Questioned in Current Era of PCI for ACS: CHANGE DAPT – Medscape (free registration required) AND CHANGE DAPT: Study Contests Benefit of Ticagrelor Over Clopidogrel After PCI in ACS – TCTMD (free)

 

10 – Resistance training may prevent obese older people becoming frail when losing weight – NIHR Signal (free)

Original article: Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults – New England Journal of Medicine (link to abstract – $ for full-text) AND Video Summary: Exercise and Dieting in Obese Older Adults (free)

 


 

#ESCCongress – Highlights from the European Society of Cardiology Congress 2017 – Part III

 

1 – #ESCCongress – Associations of fats and carbohydrate intake with cardiovascular disease and mortality in 18 countries from five continents (PURE): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Revisiting dietary fat guidelines? (PURE) – ESC Press Release (free) AND PURE Investigators: Rethink Diet Guidance to Plug More Fats, Fewer Carbs – TCTMD (free) AND International study shows moderate consumption of fats and carbohydrates best for health – McMaster University, via EurekAlert (free) AND PURE: Findings Could Have Implications For Global Dietary Guidelines – ACC News Story (free) AND Huge Diet Study Questions Conventional Wisdom About Carbs And Fats – Cardiobrief (free)

 

2 – #ESCCongress – Fruit, vegetable, and legume intake, and cardiovascular disease and deaths in 18 countries (PURE): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Reassessing the benefits of plant-based eating (PURE) – ESC Press Release (free) Fruit, Vegetable, Legume Intake and CVD Events – American College of Cardiology, Latest in Cardiology (free) AND Life-saving fruit and vegetable diet need only be three portions – study – The Guardian (free) AND Less Is More? Health Benefits of Fruits, Vegetables, and Legumes Seen at Lower Intake Levels – TCTMD (free)

 

3 – #ESCCongress – Study confirms safety of rapid algorithm to rule-out and rule-in myocardial infarction – ESC Press Release (free) (the results have not been published yet)

Commentary: ESC Rapid Rule-In, Rule-Out Algorithm for NSTEMI Safe, Accurate – Medscape (free registration required)

Related guideline: 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (free) AND Other Resources (free)

 

4 – #ESCCongress – Underweight associated with highest mortality and costs after cardiac catheterization (free) (the results have not been published yet)

Commentaries: Underweight and Overlooked: Low BMI Patients May Be Highest-Risk Post-PCI – TCTMD (free) AND Underweight Patients Fare Worse After Heart Catheterization – Medscape (free registration required) AND ESC 2017: Underweight Is Associated With Highest Mortality and Costs After Cardiac Catheterization – PracticeUpdate (free registration required)

 

5 – #ESCCongress – Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease – New England Journal of Medicine (free)

Commentaries: Anacetrapib REVEALs ‘Modest’ Effect on Cardiovascular Outcomes – Medscape (free registration required) AND Anacetrapib Finds (Modest) Success Where All Other CETP Inhibitors Failed – TCTMD (free) AND REVEAL Revealed: A Slightly Positive CETP Inhibitor Trial – Cardiobrief (free)

Interesting new drug, but with modest benefits. During the median follow-up period of 4.1 years, the primary outcome occurred in fewer patients in the anacetrapib group than in the placebo group (10.8% vs. 11.8% / absolute risk difference = 1%, meaning 100 patients would have to be treated for 4.1 years to benefit 1 patient)

 

6 – #ESCCongress – Automatic external defibrillators save lives in amateur sports and fitness centres (free) (the results have not been published yet)

“Neurologically intact survival was 93% for patients treated with an onsite Automatic external defibrillator (AED) compared to 9% without an AED”

 

7 – Richard Lehman’s journal review, 29 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – The role of nutritional support in the physical and functional recovery of critically ill patients: a narrative review – Critical Care (free)

 

9 – Management of Patients with Advanced Prostate Cancer: The Report of the Advanced Prostate Cancer Consensus Conference APCCC 2017 – European Urology (free)

Commentary: International Consensus (or Not) on Management of Advanced Prostate Cancer – ASCO Post (free)

 

10 – Clinical Report: Pediatric Integrative Medicine – American Academy of Pediatrics (free)

AAP News: From acupuncture to yoga, report updates integrative medicine therapies (free)

Commentaries: AAP Recommendations Address Complementary Therapies – Medscape (free registration required) AND AAP: Counsel on Complementary Medicine: Natural doesn’t always mean safe – MedPage Today (free registration required)

 


 

#ESCCongress – Highlights from the European Society of Cardiology Congress 2017 – Part II

 

1 – #ESCCongress – Oxygen Therapy in Suspected Acute Myocardial Infarction – New England Journal of Medicine (free)

Editorial: Is Oxygen Therapy Beneficial in Acute Myocardial Infarction? Simple Question, Complicated Mechanism, Simple Answer (free)

Commentaries: Oxygen therapy does not improve survival in patients with heart attack symptoms (DETO2X-AMI) – ESC Press Releases (free) AND Supplemental Oxygen Provides No Benefit to Patients With Suspected MI: DETO2X-AMI – TCTMD (free) AND Suspected MI and Normal Oxygen Saturation? Don’t Bother with Supplemental Oxygen – Physician’s First Watch (free)

 

2 – #ESCCongress – Population screening and intervention for vascular disease in Danish men (VIVA): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Screening for vascular disease saves one life for every 169 patients assessed (VIVA) – ESC Press Releases (free) AND VIVA: Could Population-Wide Screening Trial for AAA, PAD, and Hypertension Save Lives at Low Cost? – TCTMD (free) AND VIVA: Overall Mortality Significantly Reduced Among Older Men Receiving Triple Vascular Screening – American College of Cardiology, Latest in Cardiology (free)

 

3 – #ESCCongress – PATHWAY-2 uncovers main cause of drug-resistant hypertension, finds old drugs work best – ESC Press Releases (free) (the results have not been published yet)

Commentary: Prevention And Treatment of Hypertension With Algorithm based therapY-2 – PATHWAY-2 – American College of Cardiology, Latest in Cardiology (free)

 

4 – #ESCCongress – Bag-mask ventilation fails to improve on endotracheal intubation in cardiac arrest (CAAM) – ESC Press Releases (free) (the results have not been published yet)

Commentary: CAAM: Is Bag-Mask Ventilation Superior to ETI During CPR? – American College of Cardiology, Latest in Cardiology (free)

 

5 – #ESCCongress – Closure of left atrial appendage during heart surgery protects the brain (LAACS) – ESC Press Releases (free) (the results have not been published yet)

Commentary: LAACS: LAA Closure May Protect Against Long-Term Cerebral Ischemic Events – American College of Cardiology, Latest in Cardiology (free)

 

6 – #ESCCongress – Risk factor driven upstream atrial fibrillation therapy improves sinus rhythm maintenance (RACE 3) – ESC Press Releases (free) (the results have not been published yet)

Commentaries: Broad, Early AF Risk-Factor Intervention Preserves Sinus Rhythm: RACE-3 – Medscape (free registration required) AND Routine vs. Aggressive upstream rhythm Control for prevention of Early persistent atrial fibrillation in heart failure study – RACE 3 – American College of Cardiology, Latest in Cardiology (free)

 

7 – #ESCCongress – The Prognostic Value of Coronary Artery Calcium in the PROMISE Study – Circulation (free PDF)

Editorial: Computed Tomography or Functional Stress Testing for the Prediction of Risk: Can I Have My Cake and Eat It? (free PDF)

Commentary: Prospective Multicenter Imaging Study for Evaluation of Chest Pain – PROMISE – American College of Cardiology, Latest in Cardiology (free)

 

8 – Why developing countries must improve primary care – The Economist (free) (RT @AnjaNitzscheB see Tweet)

“The changing burden of disease requires a better approach to keeping people healthy”

 

9 – Necrotizing pancreatitis: Diagnose, treat, consult – Cleveland Clinic Journal of Medicine (free)

Source: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)

 

10 – Using mesh does not improve results in vaginal prolapse surgery – NIHR Signal (free)

Original article: Mesh, graft, or standard repair for women having primary transvaginal anterior or posterior compartment prolapse surgery: two parallel-group, multicentre, randomised, controlled trials (PROSPECT) – The Lancet (free) AND Commentary: Mesh, graft, or standard repair for prolapse surgery? – The Lancet (free)

“About 12% of vaginal prolapse patients had complications from surgery using mesh” (RT @NIHR_DC see Tweet)

 


 

#ESCCongress – Highlights from the European Society of Cardiology Congress 2017

 

1 – 2017 ESC/EACTS Guidelines for the management of valvular heart disease (free) (RT @rafavidalperez see Tweet)

Commentary: European Societies Issue New Valvular Heart Disease Guidelines, With Important Shifts – TCTMD (free)

See also: #ESCCongress Slides (free PPT file)

 

2 – 2017 ESC Guidelines for the management of acute myocardial infarction in patients presenting with ST-segment elevation: The Task Force for the management of acute myocardial infarction in patients presenting with ST-segment elevation of the European Society of Cardiology (ESC) (free) (RT @rafavidalperez see Tweet)

Commentary: ESC Updates Guidelines for Treating STEMI Patients – TCTMD (free)

See also: #ESCCongress Slides (free PPT file)

 

3 – 2017 ESC Guidelines on the Diagnosis and Treatment of Peripheral Arterial Diseases, in collaboration with the European Society for Vascular Surgery (ESVS): Document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries (free) (RT @rafavidalperez see Tweet)

See also: #ESCCongress Slides (free PPT file)

 

4 – 2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS (free) (RT @rafavidalperez see Tweet)

See also: #ESCCongress Slides (free PPT file)

 

5 – Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease – New England Journal of Medicine (free)

Editorial by Dr. Eugene Braunwald: An Important Step for Thrombocardiology (free)

Commentaries: Cardiovascular Outcomes for People Using Anticoagulation Strategies – COMPASS – American College of Cardiology, Latest in Cardiology (free) AND COMPASS: Does Rivaroxaban Plus Aspirin Improve CV Outcomes in Patients With Stable Atherosclerotic Vascular Disease or PAD? – ACC News Story (free) AND Rivaroxaban, Aspirin, or Both in Stable Coronary Disease – Physician’s First Watch (free)

The primary outcome (composite of cardiovascular death, stroke, or myocardial infarction) occurred in fewer patients in the rivaroxaban-plus-aspirin group than in the aspirin-alone group (4.1% vs. 5.4% / Absolute risk difference = 1.3% / NNT = 76), but major bleeding events occurred in more patients in the rivaroxaban-plus-aspirin group (3.1% vs. 1.9% / Absolute risk difference = 1.2 / NNH = 83).

 

6 – Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation – New England Journal of Medicine (free)

Commentaries: Randomized Evaluation of Dual Antithrombotic Therapy With Dabigatran vs. Triple Therapy With Warfarin in Patients With Nonvalvular Atrial Fibrillation Undergoing Percutaneous Coronary Intervention – RE-DUAL PCI – American College of Cardiology, Latest in Cardiology (free) Dual Antithrombotic Therapy Is Safe for Patients with AF and a New Stent – Physician’s First Watch (free) AND When two is better than three: Dual antithrombotic therapy cuts bleeding risk – Brigham and Women’s Hospital, via ScienceDaily (free)

“In summary, several lines of evidence now suggest that it is safe to treat atrial fibrillation patients who undergo coronary revascularization with anticoagulation (warfarin studied in WOEST, rivaroxaban studied in PIONEER AF-PCI, dabigatran studied in RE-DUAL PCI) and clopidogrel monotherapy” (from American College of Cardiology, Latest in Cardiology).

 

7 – Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease – New England Journal of Medicine (free)

Editorial: Targeting Inflammation in Coronary Artery Disease (free)

Commentaries: Anti-Inflammatory Therapy for Atherosclerotic Disease: A Step Closer? – Physician’s First Watch (free) AND CANTOS: Anti-inflammatory Agent Canakinumab Modestly Reduces Major CVD Events – TCTMD (free) AND CANTOS Validates Role Of Inflammation In Heart Disease – Cardiobrief (free)

“This widely anticipated study delivered some modestly positive results (fewer nonfatal MIs), some worrisome results (increased fatal infections), and some unexpected results (fewer cancer deaths)” (from Physician’s First Watch). 

 

8 – Catheter ablation improves outcomes in patients with heart failure and atrial fibrillation (CASTLE-AF) (free)

Commentary: CASTLE-AF: Catheter Ablation vs. Conventional Therapy For Patients With AFib and LV Dysfunction – American College of Cardiology, Latest in Cardiology (free)

The study has not been published yet, but the results suggest that patients with symptomatic paroxysmal or persistent AF and heart failure with ejection fraction less than 35% may have a better outcome with catheter ablation.

 

9 – Incidence of Previously Undiagnosed Atrial Fibrillation Using Insertable Cardiac Monitors in a High-Risk Population: The REVEAL AF Study (free)

Commentaries: What Do Implanted Cardiac Monitors Reveal About Atrial Fibrillation? – JAMA Cardiology (free) AND REVEAL AF: Incidence of AFib Could Be Substantial in Older Patients With Stroke Risk Factors – American College of Cardiology, Latest in Cardiology (free) AND Detection of Undiagnosed AF Using Insertable Cardiac Monitors – American College of Cardiology, Latest in Cardiology (free)

Implanted Cardiac Monitors showed the incidence of intermittent atrial fibrillation is extremely common among older individuals with stroke risk factors, but the clinical significance of these findings (do they need to be anticoagulated??) remains to be determined by further trials.

“Previous long-term monitoring studies have suggested that patients with short episodes of subclinical AF have a lower risk of stroke compared with traditional clinical AF, which raises important questions about the risk-benefit ratio of anticoagulation in this setting” (from Latest in Cardiology).

 

10 – CI Versus CABG in Patients With Type 1 Diabetes and Multivessel Disease – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Patients With Type 1 Diabetes and Multivessel Disease Have Greater Benefit From CABG Than PCI – American College of Cardiology, Latest in Cardiology (free) AND Revascularization in Patients With Type 1 Diabetes – American College of Cardiology, Latest in Cardiology (free) AND CABG Appears Superior to PCI for Patients With Type 1 Diabetes, Multivessel Disease – TCTMD (free)

“The observational findings support existing recommendations favoring surgical revascularization in patients with diabetes” (from TCTMD).

 


 

1 – Diabetes and Hypertension: A Position Statement by the American Diabetes Association (free) (RT @Abraham_RMI and @ADA_Journals see Tweet)

Commentary: ADA Offers Position Statement on Diabetes and Hypertension – AJMC (free)

“the guideline continues the advice that most patients with diabetes should be treated to a blood pressure goal of <140/90 mm Hg; a goal of <130/80 can be considered for patients who have other cardiovascular risk factors” (from AJMC)

 

2 – Global, Regional, and National Burden of Rheumatic Heart Disease, 1990–2015 – New England Journal of Medicine (free)

Editorial: Rheumatic Heart Disease — An Iceberg in Tropical Waters (free) (RT @NEJM see Tweet with interesting table)

Quick Take Video Summary: What is the Global Burden of Rheumatic Heart Disease? (free)

Commentary: Death rates from rheumatic heart disease falling since 1990 – Institute for Health Metrics and Evaluation (free)

 

3 – Long-Term, Supplemental, One-Carbon Metabolism–Related Vitamin B Use in Relation to Lung Cancer Risk in the Vitamins and Lifestyle (VITAL) Cohort – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentaries: Vitamin B supplements linked to lung cancer – here’s why you probably don’t need to worry – The Conversation (free) AND High Doses of Vitamin B Linked to Lung Cancer Increase – Medscape (free registration required) AND High Dose Vitamin B Supplements Should Not Be Taken for Lung Cancer Prevention – Cancer Therapy Advisor (free) AND High doses of vitamin B tied to lung cancer risk, study says – CNN (free)

 

4 – Association of Lithium in Drinking Water With the Incidence of Dementia – JAMA Internal Medicine (free)

Editorial: Could Lithium in Drinking Water Reduce the Incidence of Dementia? (free)

Commentaries: Lithium in drinking water may affect Alzheimer’s risk – Reuters (free) AND Dementia Rates Fall with Rising Lithium Levels in Water – MedPage Today (free registration required) AND Lithium in Drinking Water Linked to Lower Dementia Risk? – Physician’s First Watch (free) AND Lithium in tap water may cut dementia – BBC Health (free)

 

5 – The Case for a Breakfast Feast – The New York Times (free)

Related article: Meal Frequency and Timing Are Associated with Changes in Body Mass Index in Adventist Health Study 2 – The Journal of Nutrition (link to abstract – $ for full-text)

 

6 – EULAR recommendations for the use of imaging in the clinical management of peripheral joint osteoarthritis – Annals of Rheumatic Diseases (free)

 

7 – British Society of Gastroenterology position statement on serrated polyps in the colon and rectum – Gut (free)

 

8 – Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory tract infections in 195 countries: a systematic analysis for the Global Burden of Disease Study 2015 – Lancet Infectious Diseases (free) (RT @simonihay and @IHME_UW see Tweet)

Invited commentary: Measuring progress on preventing pneumonia deaths: are we there yet? (free)

 

9 – A bold open-access push in Germany could change the future of academic publishing – Science (free) (RT @hildabast and @RickyPo see Tweet)

Related commentary: Sci-Hub’s cache of pirated papers is so big, subscription journals are doomed, data analyst suggests – Science (free)

 

10 – Drug reduces deaths from bleeding after childbirth – NIHR Signal (free)

Original article: Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial – The Lancet (free) and Editorial: WOMAN: reducing maternal deaths with tranexamic acid (free)

“Tranexamic acid reduces risk of death from bleeding after childbirth by 31% when given within three hours”. (RT @NIHR_DC see Tweet)

 


 

1 – Effect of Oral Prednisolone on Symptom Duration and Severity in Nonasthmatic Adults With Acute Lower Respiratory Tract Infection: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Oral Steroid Does Not Reduce Lower Respiratory Tract Infection Symptoms in Nonasthmatic Adults – JAMA Network (free) AND No Benefit for Oral Steroids in Lower Respiratory Tract Infection – Medscape (free registration required) AND Don’t use steroids for chest infections, GPs advised – Pulse (free)

In patients with acute respiratory infection without evidence of pneumonia or asthma, the addition of corticosteroids did not reduce symptom duration or severity.

 

2 – Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis of Individual Patient Data – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Outcomes of limited cancer screening after unprovoked VTE similar to extensive screening – ACP Hospitalist (free) AND Cancer Screening Not Recommended in Patients With VTEs – Medscape (free registration required) AND Extensive cancer screening may not improve outcomes for patients with unprovoked venous thromboembolism – 2 Minute Medicine (free) AND Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism – ASCO Post (free)

 

3 – Splenic trauma: WSES classification and guidelines for adult and pediatric patients – World Journal of Emergency Surgery (free)

 

4 – Longer sleep is associated with lower BMI and favorable metabolic profiles in UK adults: Findings from the National Diet and Nutrition Survey – PLOS One (free)

Commentaries: Short sleep linked to body mass, waist size – Reuters (free) AND Insufficient sleep may be adding to your waistline – University of Leeds, via Science Daily (free)

 

5 – ESO-ESMO 3rd international consensus guidelines for breast cancer in young women (BCY3) – The Breast (free)

 

6 – Update of EULAR recommendations for the treatment of systemic sclerosis – Annals of Rheumatic Diseases (free)

 

7 – Effect of Natriuretic Peptide–Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Natriuretic Peptide-Guided Therapy No Better Than Usual Care in Heart Failure Patients – Physician’s First Watch (free) AND NT-proBNP Tx Disappoints for HF Drug Titration – MedPage Today (free registration required)

 

8 – Global Burden of Sugar-Related Dental Diseases in 168 Countries and Corresponding Health Care Costs – Journal of Dental Research (link to abstract – $ for full-text)

Commentaries: High sugar consumption gives rise to dental treatment costs in the billions – Science Daily (free)

Worldwide, people are eating far too much sugar. This has negative consequences for their teeth and for their purses: seen at the global level, the costs of dental treatment are currently running at around $172 billion”

 

9 – Benefits and Harms of Osteoporosis Medications in Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Benefits and harms of osteoporosis medications unclear for patients with CKD – Medical News Today (free) AND Benefits and harms of osteoporosis medications unclear for patients with CKD – 2 Minute Medicine (free)

Source: ACP Journal Club ($)

 

10 – National Estimates of Reductions in Acute Gastroenteritis–Related Hospitalizations and Associated Costs in US Children After Implementation of Rotavirus Vaccines – Journal of the Pediatric Infectious Diseases Society (free)

Commentary: Rotavirus vaccines continue to reduce diarrhea hospitalizations, medical costs in US kids – Medical News Today (free) AND Study: Rotavirus vaccine cuts healthcare costs in US children – CIDRAP (free)

 


 

1 – Risk of Arterial Thromboembolism in Patients With Cancer – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Cancer Patients at Heightened Risk for Arterial Thromboembolism – American College of Cardiology, Latest in Cardiology (free) AND Thromboembolism Risk Doubled in Cancer Patients – Medscape (free registration required) AND Cancer patients carry double the short-term risk of arterial thromboembolism – Cardiovascular Business (free) AND Short-Term Risk of Arterial Thromboembolism in Newly Diagnosed Patients With Cancer – ASCO Post (free)

 

2 – Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial – JAMA (free)

Multimedia: Author Interview (free) AND JAMA Report Video (free)

Commentaries: Study Examines Effectiveness of Steroid Medication for Sore Throat – The JAMA Network (free) AND Corticosteroids for sore throat: a mixed bag of results – Clinical Advisor (free)

Source: ACP Journal Club ($)

Dexamethasone increased complete symptom resolution at 48 hours (35.4% vs 27.1%), but not at 24 hours. Trade-offs between the benefits and risks of dexamethasone in this situation are uncertain.

 

3 – Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 – Intensive Care Medicine (free)

Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine

 

4 – Guideline: Antenatal Corticosteroid Therapy for Fetal Maturation – American College of Obstetricians and Gynecologists (free)

See also: Summary

Related: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth – Cochrane Library (link to abstract – $ for full-text) AND A dose of corticosteroids benefit most women anticipating a preterm delivery – NIHR Signals (free)

 

5 – Guideline: Opioid Use and Opioid Use Disorder in Pregnancy – American College of Obstetricians and Gynecologists (free)

See also: Summary

Related: Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes: Executive Summary of a Joint Workshop by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, American Academy of Pediatrics, Society for Maternal-Fetal Medicine, Centers for Disease Control and Prevention, and the March of Dimes Foundation (free)

 

6 – Is Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage among Obese and Overweight Patients as Assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative – Radiology (link to abstract – $ for full-text)

Commentaries: Weight Loss Can Slow Down Knee Joint Degeneration – RSNA Press Release (free) AND Osteoarthritis: Knee joint degeneration slowed with weight loss, study confirms – Medical News Today (free)

 

7 – Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification – Circulation (free)

Commentaries: Air pollution ups stress hormones, alters metabolismo – Reuters (free) AND AND Novel Study Shows How Air Pollution Increases CVD Risk – MedPage Today (free registration required) AND Air pollution linked to cardiovascular disease; air purifiers may lessen impact – American Heart Association, via Science Daily (free)

Related: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)

 

8 – Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Commentary: ASCO Guideline on Stage IV NSCLC Therapy Updated – ASCO Post (free)

 

9 – The Saudi Thoracic Society guidelines for diagnosis and management of noncystic fibrosis bronchiectasis – Annals of Thoracic Medicine (free)

 

10 – Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets – Cancer Cell (free)

Commentaries: Liquid Biopsy Reads RNA Collected by Platelets to Diagnose Cancer – Genetic Engineering & Biotechnology News (free) AND Blood biopsy test reads platelets to detect human lung cancer – Cell Press, via EurekAlert (free)

Related: Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer – New England Journal of Medicine (link to abstract – $ for full-text) AND Video – EBV DNA Screening for Nasopharyngeal Carcinoma (free) AND Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free) AND Plasma Epstein–Barr virus DNA useful for nasopharyngeal carcinoma screening – 2 Minute Medicine (free)

 


 

1 – Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents – American Academy of Pediatrics (free)

News release: AAP issues new pediatric hypertension clinical practice guideline – AAP News (free)

 

2 – Factors Associated With Choice of Infant Sleep Position – Pediatrics (free)

Commentaries: Less than half of mothers place sleeping infants supine – 2 Minute Medicine (free) AND Most moms aren’t putting babies to sleep safely, study says – CNN (free) AND Less Than Half of Mothers Report Always Putting Babies to Sleep in Supine Position – Physician’s First Watch (free) AND Parents still failing to put babies to sleep on their backs – Reuters (free)

Placing infants in the supine position for sleep reduces the risk of sudden unexpected infant death and has been recommended by the American Academy of Pediatrics since 2005. Nevertheless, in this survey only 43,7% of mothers placed their infants exclusively in supine position for sleep.

 

3 – Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease – Perinatal and Paediatric Epidemiology (free)

Commentaries: Study: Hypertension in pregnancy may affect long-term heart health – UPI (free) AND Hypertension during pregnancy may affect women’s long-term cardiovascular health – Wiley, via EurekAlert (free)

Related: Women with High-Risk Pregnancies Are More Likely To Develop Heart Disease – NPR (free) AND Adverse Pregnancy Conditions, Infertility, and Future Cardiovascular Risk: Implications for Mother and Child – Cardiovascular Drugs and Therapy (free)

 

4 – Medical News & Perspectives: Chess Study Revives Debate Over Cognition-Enhancing Drugs – JAMA (free)

Related: Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)

 

5 – When surgery is just a stitch-up – The Guardian (RT @Onisillos  see Tweet)

Related article: Use of placebo controls in the evaluation of surgery: systematic review – The BMJ (free)

“With evidence mounting that many minor operations owe their success to the placebo effect, is it time to call a halt to some routine procedures?”

 

6 – Smoking Cessation Pharmacotherapy Among Smokers Hospitalized for Coronary Heart Disease – JAMA Internal Medicine (free)

Commentaries: Smokers hospitalized for heart attacks often don’t get cessation drugs – Reuters (free) AND Smokers Hospitalized for CHD Rarely Receive Cessation Pharmacotherapy During Hospitalization – American College of Cardiology, Latest in Cardiology (free)

 

7 – Re-analysis of All-Cause Mortality in the U.S. Preventive Services Task Force 2016 Evidence Report on Colorectal Cancer Screening – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Flexible Sigmoidoscopy Tied to Lower Mortality Risk – Physician’s First Watch (free) AND Flexible Sigmoidoscopy Reduces All-Cause Mortality – Medscape (free registration required)

 

8 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes – Diseases of the Colon & Rectum (free)

 

9 – Oncological patients in the intensive care unit: prognosis, decision-making, therapies and end-of-life care – Swiss Medical Weekly (free)

Source: Critical Care Review Newsletter

 

10 – Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study – Annals of Rheumatic Diseases (link to abstract – $ for full-text)

Commentaries: Elevated Uric Acid Linked to Dementia in the Elderly – MedPage Today (free registration required) AND Dementia risk may be higher in elderly patients with high serum uric acid levels – ACP Internist (free)

 


 

1 – A randomized synbiotic trial to prevent sepsis among infants in rural India – Nature (free PDF)

Commentaries: At Last, a Big, Successful Trial of Probiotics – The Atlantic (free) AND Probiotic Bacteria Could Protect Newborns From Deadly Infection – NPR Goats and Soda (free) AND Seeding the Gut Microbiome Prevents Sepsis in Infants – The Scientist (free)

 

2 – Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 – Lancet Respiratory Medicine (free)

Invited commentary: COPD and asthma: the emergency is clear, now is the time for action (free)

 

3 – Perspective: Saying Goodbye to Lectures in Medical School: Paradigm Shift or Passing Fad? – New England Journal of Medicine (free)

Related: Vermont Medical School Says Goodbye To Lectures – NPR (free)

 

4 – Analysis – Too much medicine: Mapping the drivers of overdiagnosis to potential solutions – The BMJ (free)

Related: Overdiagnosis, ethics, and trolley problems: why factors other than outcomes matter – The BMJ (free) AND The overdiagnosis community targets solutions – The BMJ (free) AND Are expanding disease definitions unnecessarily labelling women with polycystic ovary syndrome? – The BMJ (free) AND When technology creates uncertainty: pulse oximetry and Overdiagnosis of hypoxaemia in bronchiolitis – The BMJ (free)

 

5 – The global burden of tuberculosis mortality in children: a mathematical modelling study – The Lancet Global Health (free)

Commentaries: Tuberculosis in children: under-counted and under-treate – The Lancet Global Health (free) AND TB killed an estimated 239,000 children in 2015, nearly all of them untreated, study finds – Science Speaks Blog (free)

 

6 – A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials – BMC Nephrology (free)

Source: Critical Care Reviews Newsletter

Early initiation of RRT in critically ill patients did not result in reduced mortality, change in renal function recovery, duration of RRT, renal recovery time, mechanical ventilation time or complications.

 

7 – Recommendations for HIV Screening of Gay, Bisexual, and Other Men Who Have Sex with Men — United States, 2017 – CDC, MMWR (free)

@CDC_HIVAIDS recommends men who have sex with men be tested for HIV at least annually”. (RT @CDCMMWR see Tweet)

 

8 – Special issue: Topical Collection on Decompensated Heart Failure – Current Heart Failure Reports

Source: Critical Care Reviews Newsletter

– Inpatient Monitoring of Decompensated Heart Failure: What Is Needed? (free)

– Acute Heart Failure: Definition, Classification and Epidemiology (free)

– Mechanical Circulatory Support for Decompensated Heart Failure (free)

– Pharmacological and Non-pharmacological Treatment for Decompensated Heart Failure: What Is New? (free)

– Venous Congestion, Endothelial and Neurohormonal Activation in Acute Decompensated Heart Failure: Cause or Effect? (free)

– Current Approach to Decongestive Therapy in Acute Heart Failure (free)

 

9 – A National Implementation Project to Prevent Catheter-Associated Urinary Tract Infection in Nursing Home Residents – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Study Shows 54 Percent Drop in CAUTIs Among Nursing Home Residents – Infection Control Today (free) AND AHRQ safety program helps cut catheter infections by more than 50% among nursing home patients, JAMA study shows – Healthcare Finance (free) AND Implementing technical and socioadaptive bundles may decrease catheter-associated urinary tract infections in nursing homes – 2 Minute Medicine (free) AND Nursing homes cut urinary tract infections in half through focused effort on catheter care – Michigan University, via EurekAlert (free)

Related: Toolkit for Reducing Catheter-Associated Urinary Tract Infections (CAUTI) – Agency for Healthcare Research and Quality (free resources)

 

10 – Review: The role of bariatric surgery to treat diabetes: current challenges and perspectives – BMC Endocrine Disorders (free)

 


 

1 – Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis – European Heart Journal (link to abstract – $ for full-text)

Commentaries: ‘Fat but fit’ people may still be at risk of heart disease – NHS Choices (free) AND ‘Fat but fit’ still has higher risk of heart disease, study confirms – CNN (free) AND ‘Fat but Fit’ is Myth; New UK Study Finds BMI>25 Ups MI Risk – Medscape (free registration required) AND ‘Fat but fit’ still risk heart disease – BBC (free)

 

2 – Clinical Practice Guideline: Safe Medication Use in the ICU – Critical Care Medicine (free)

See also: Executive Summary (free)

 

3 – Free Online Courses Starting Today

– Introduction to Health Technology Assessment – University of Glasgow and FutureLearn

– Science of Exercise – University of Colorado Boulder and Coursera

– Psychological First Aid – Johns Hopkins University and Coursera

– Epidemiology in Public Health Practice – Johns Hopkins University and Coursera

– Tropical Parasitology: Protozoans, Worms, Vectors and Human Diseases – Duke University, Kilimanjaro Christian Medical University College and Coursera

– Essentials of Global Health – Yale University and Coursera

– Understanding Cancer Metastasis – Johns Hopkins University and Coursera

– Advanced Neurobiology I – Peking University and Coursera

– Anatomy of the Abdomen and Pelvis; a journey from basis to clinic – Leiden University Medical Center and Coursera

– Systems Thinking In Public Health – Jonhs Hopkins University and Coursera

– Bacteria and Chronic Infections – University of Copenhagen and Coursera

– Introduction to Breast Cancer – Yale University and Coursera

– Healthcare Innovation and Entrepreneurship – Duke University and Coursera

– Foundations for Assisting in Home Care – The State University of New York and Coursera

 

4 – Acute Kidney Injury After Computed Tomography: A Meta-analysis – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary: When kidneys are injured, CT contrast isn’t the culprit – Health Imaging (free)

Related article: Risk of Acute Kidney Injury After Intravenous Contrast Media Administration – Annals of Emergency Medicine (free)

Source: Hospital Medicine Virtual Journal Club

Compared with noncontrast CT, contrast-enhanced CT was not significantly associated with either acute kidney injury, need for renal replacement therapy, or all-cause mortality.

 

5 – Trajectories of energy drink consumption and subsequent drug use during young adulthood – Drug & Alcohol Dependence (link to abstract – $ for full-text)

Commentaries: Study suggests energy drinks can lead to cocaine use – News.com.au (free text and video) AND Energy Drinks May Trigger Future Substance Use – Medscape (free registration required)

 

6 – Sleep Duration and Risk of Type 2 Diabetes – Pediatrics (link to abstract – $ for full-text)

Commentaries: Lack of sleep tied to higher risk of diabetes in kids – Reuters (free) AND Sleep in Children Linked to Later Risk of Type 2 Diabetes – AJMC (free) AND Insufficient sleep raises type 2 diabetes risk in children – Medical News Today (free) AND Sleep duration inversely related to childhood type 2 diabetes risk makers – 2 Minute Medicine (free)

 

7 – Review: Postoperative pulmonary complications – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Topic of The Week

 

8 – When Sports Injuries Lead to Arthritis in Joints – The New York Times (10 articles per month are free)

Related guideline: The Role of Athletic Trainers in Preventing and Managing Posttraumatic Osteoarthritis in Physically Active Populations: a Consensus Statement of the Athletic Trainers’ Osteoarthritis Consortium (free)

 

9 – NCCN Guidelines Insights: Palliative Care, Version 2.2017 – JNCCN (free)

Related guidelineIntegration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

10 – Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks’ gestation in France in 2011: EPIPAGE-2 cohort study – The BMJ (free)

Commentaries: Ahead of their time – The BMJ (free) AND Preemies do better now than years ago, but still at risk – Reuters (free) AND Premature baby survival rates are improving – OnMedica (free)

 


 

1 – Special issue: 60 years of metformin use – Diabetologia (Source: ACP Diabetes Monthly)

– Editorial: 60 years of metformin use: a glance at the past and a look to the future (free)

– Metformin: historical overview (free)

– The mechanisms of action of metformin (free)

– Metformin: clinical use in type 2 diabetes (free)

– A new perspective on metformin therapy in type 1 diabetes (free)

– Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study (free)

– Metformin use in pregnancy: promises and uncertainties (free)

– Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes (free)

– Metformin and ageing: improving ageing outcomes beyond glycaemic control (free)

– Repurposing metformin for the prevention of cancer and cancer recurrence (free)

– The pharmacogenetics of metformin (free)

– Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome (free)

– The effects of metformin on gut microbiota and the immune system as research frontiers (free)

 

2 – Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 – Science (link to abstract – $ for full-text)

Commentaries: Birth of CRISPR’d pigs advances hopes for turning swine into organ donos – STAT (free) AND Gene editing to remove viruses brings transplant organs from pigs a step closer – The Guardian (free) AND Gene Editing Spurs Hope for Transplanting Pig Organs Into Humans – New York Times (10 articles per month are free) AND Gene editing brings pig organ transplant closer – NHS Choices (free) AND Scientists edit pig genome with goal of human organ transplants – CNN (free text and video)

 

3 – Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Off-Pump CABG Raises Long-Term Mortality Risk – Cardiobrief (free) AND Newer method of open-heart surgery carries more risks, study finds – STAT (free)

 

4 – Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials – PLOS Medicine (free)

Commentaries: Gabapentinoids Seem to Offer Little Benefit, Substantial Risks in Low Back Pain – Physician’s First Watch (free) AND Evidence does not support the use of gabapentinoids for chronic low back pain – PLOS, via Science Daily (free) AND Gabapentinoids for Chronic Low Back Pain? Not So Fast – Practical Pain Management (free)

Pregabalin and gabapentin have significant risk of adverse effects without any demonstrated benefit in chronic low back pain.

 

5 – Bored reading science? Let’s change how scientists write – The Conversation (free) (RT @Onisillos see Tweet)

“Science communicators, journalists, entrepreneurs, policymakers and interested members of the general public are all motivated to follow the latest scientific research. And yet, strangely enough, science papers are a communication tool but they are not that effective at communication”.

 

6 – The Fight Against Antibiotic-Resistant Bacteria Might Start With Vaccines – Allice Callahan, via FiveThirtyEight (free) (RT @greg_folkers see Tweet with infographic)

 

7 – Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: SGLT2 Agents Cut CV Events in ‘Real-World’ Analysis – MedPage Today (free registration required) AND Cardiovascular disease and mortality appear lower in patients on SGLT2 inhibitors – ACP Diabetes (free)

Related article: Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study – Circulation (free PDF)

Another observational study suggests this class of drugs may reduce cardiovascular mortality and morbidity.

 

8 – The Risk of Adverse Pregnancy Outcomes Following Nonobstetric Surgery During Pregnancy: Estimates From a Retrospective Cohort Study of 6.5 Million Pregnancies – Annals of Surgery (free)

Source: Journal Watch ($)

we found that the risk associated with nonobstetric surgery was relatively low, confirming that surgical procedures during pregnancy are generally safe”

 

9 – Study: diet soda can really mess with your metabolism – VOX (free)

Original article: Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward – Current Biology (link to abstract – $ for full-text)

See also a related meta-analysis showing little evidence of benefit from the consumption of artificial sweeteners for weight loss in our July 18th issue (see #2)

“New research helps explain why artificial sweeteners are linked to obesity and metabolic disease”.

 

10 – Talking therapy given by parents shows promise for childhood anxiety disorders – NIHR Signal (free)

Original article: Clinical outcomes and cost-effectiveness of brief guided parent-delivered cognitive behavioural therapy and solution-focused brief therapy for treatment of childhood anxiety disorders: a randomised controlled trial – The Lancet Psychiatry (free) AND Commentary: Low-intensity interventions for anxiety disorders (free)

“70% of children receiving guided parent-delivered CBT had recovered from anxiety six months after treatment” (RT @NIHR_DC see Tweet)

 


 

1 – The Effects of Cannabis Among Adults With Chronic Pain and an Overview of General Harms: A Systematic Review – Annals of Internal Medicine (free)

Related article: Benefits and Harms of Plant-Based Cannabis for Posttraumatic Stress Disorder: A Systematic Review – Annals of Internal Medicine (free)

Commentaries: Evidence on cannabis for chronic pain and PTSD – American College of Physician’s, via EurekAlert (free) AND Evidence Lacking on Benefits of Cannabis for Treating Chronic Pain, PTSD – Physician’s First Watch (free) AND Limited evidence available to determine effectiveness and safety of cannabis to treat chronic pain – 2 Minute Medicine (free) AND Little evidence that marijuana helps chronic pain, PTSD, studies find – CNN (free text and video)

 

2 – Blood pressure targets for hypertension in older adults – Cochrane Library (free)

Full review: Blood pressure targets for hypertension in older adults – Cochrane Library (link to abstract – $ for full-text)

Related guideline: Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older to Higher Versus Lower Blood Pressure Targets: A Clinical Practice Guideline From ACP and AAFP (free)

“At the present time there is insufficient evidence to know whether a higher BP target (less than150 to 160/95 to 105 mmHg) or a lower BP target (less than 140/90 mmHg) is better for older adults with high BP”

 

3 – Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: EBV DNA Screening for Nasopharyngeal Carcinoma (free)

Commentaries: Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free) AND Liquid Biopsy Passes Test for Nasopharyngeal Cancer – MedPage Today (free registration required) AND Early Detection of Nasopharyngeal Cancer With EBV DNA – Medscape (free registration required) AND Plasma Epstein–Barr virus DNA useful for nasopharyngeal carcinoma screening – 2 Minute Medicine (free)

 

4 – Association of Previous Cesarean Delivery With Surgical Complications After a Hysterectomy Later in Life – JAMA Surgery (free)

Commentaries: C-Section Delivery Associated with Increased Risk of Complications from Hysterectomy – The JAMA Network (free) AND C-Section Now, Hysterectomy Complications Later? – MedPage Today (free registration required)

 

5 – Risk of head and traumatic brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer’s disease: a nationwide matched cohort study – Alzheimer’s Research & Therapy (free)

Commentary: Antidepressant use increases risk of head injuries among persons with Alzheimer’s disease – University of Eastern Finland, via EurekAlert (free)

 

6 – Cholera count reaches 500 000 in Yemen – World Health Organization (free)

Commentaries: Yemen’s cholera outbreak passes 500,000 cases – CIDRAP (free) AND More Than 500,000 Infected With Cholera in Yemen – The New York Times (10 articles per month are free)

 

7 – Surgery must be a core part of health care – even in the poorest countries – The Guardian (free)

Related book: Essential Surgery – Disease Control Priorities 3 (DCP3) (free)

Related report: Global Surgery 2030 (free PDF)

Related commentary on the subject: In countries with a shortage of surgeons, other health care workers can fill in the gaps – STAT (free)

 

8 – Dexamethasone before bowel surgery reduces postoperative nausea and vomiting – NIHR Signal (free)

Original article: Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial) – The BMJ (free)

 

9 – Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality in U.S. Adults – Journal of The American College of Cardiology (link to abstract and infographic – $ for full-text)

Commentaries: Consuming Alcohol in Moderation Can Lower Mortality Risks – American College of Cardiology, Latest in Cardiology (free) AND Alcohol Consumption and All-Cause, CV, and Cancer-Related Mortality – American College of Cardiology, Latest in Cardiology (free) AND Can drinking a little bit help you live longer? – Reuters (free)

 

10 – Addressing Alcohol Use Practice Manual: An Alcohol Screening and Brief Intervention Program – American Academy of Family Physicians (free PDF)

Press release: AAFP, Baylor Partner to Create Alcohol Screening Practice Manual (free)

Commentary: Alcohol screening and brief intervention: A practice manual for clinicians – Clinical Advisor (free)

 


 

1 – Eliminating Creatine Kinase–Myocardial Band Testing in Suspected Acute Coronary Syndrome: A Value-Based Quality Improvement – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)

Author interview: Eliminating Creatine Kinase–Myocardial Band Testing in Suspected ACS (free)

Commentaries: Eliminating CK-MB Testing in Suspected ACS – American College of Cardiology, Latest in Cardiology (free) AND Research review recommends eliminating widely ordered blood test for diagnosing heart attacks – Johns Hopkins Medicine, via Science Daily (free)

Review is first publication from national consortium of academic medical centers working to eliminate unnecessary medical tests, treatments and procedures” (from Science Daily)

 

2 – Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Midlife cardiovascular risk factors may increase chances of dementia – NIH News Releases (free) AND Midlife smoking, diabetes, and hypertension associated with late life dementia – 2 Minute Medicine (free) AND Heart-healthy middle age tied to lower risk of dementia – Medical News Today (free) AND Heart disease risk in middle age tied to dementia later – Reuters (free)

 

3 – Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study – Circulation (free)

Commentaries: Fluctuations in home-monitored blood pressure may raise dementia risk – Circulation Journal Report (free) AND Fluctuations in Blood Pressure Linked to Vascular Dementia – MedPage Today (free registration required) AND Fluctuating Home Blood Pressure Linked to Dementia – Medscape (free registration required) AND Blood pressure fluctuations linked to dementia – Reuters (free)

 

4 – Self-management interventions including action plans for patients with Chronic Obstructive Pulmonary Disease (COPD) – Cochrane Library (free)

Full review: Self-management interventions including action plans for exacerbations versus usual care in patients with chronic obstructive pulmonary disease (link to summary – $ for full-text)

Related: Asthma self-management programmes can reduce unscheduled care – NIHR Signal (free)

Self-management interventions that include a COPD exacerbation action plan are associated with improvements in health-related quality of life and lower probability of respiratory-related hospital admissions.

 

5 – Delayed breastfeeding initiation and infant survival: A systematic review and meta-analysis – PLOS One (free)

This systematic review and meta-analysis mostly of observational studies suggests early breastfeeding initiation is associated with increased survival. The authors acknowledge that there are many reasons for delayed breastfeeding initiation that may confound the relationship between breastfeeding initiation and mortality, but remember that randomized trials would not be considered ethical, so we must rely on high quality observational data. Based on their analysis, the authors suggest the implementation of programs that emphasize the importance of early initiation of breastfeeding, in addition to promoting exclusive breastfeeding.

 

6 – State of the Art Review: Advances in the diagnosis and management of neck pain – The BMJ (free)

Related guideline: Neck Pain: Revision 2017 – Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association (free)

 

7 – Neurologic Complications Associated With the Zika Virus in Brazilian Adults – JAMA Neurology (free)

Editorial: The Expanding Spectrum of Zika Virus Infections of the Nervous System (free)

Commentary: Brazilian study sheds new light on Zika neuro complications in adults – CIDRAP (free)

 

8 – Richard Lehman’s journal review, 14 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – New, Occasional, and Frequent Use of Zolpidem or Zopiclone (Alone and in Combination) and the Risk of Injurious Road Traffic Crashes in Older Adult Drivers: A Population-Based Case–Control and Case-Crossover Study – CNS Drugs (free)

Car crashes in older adult drivers: Zolpidem (aOR 2.27) > zolpidem + zopiclone combo (aOR 2.20)” (RT @psychopharmacol see Tweet)

 

10 – Risk of Stroke With Various Types of Menopausal Hormone Therapies: A National Cohort Study – Stroke (link to abstract – $ for full-text)

Source: EvidenceAlerts

This large cohort confirms an increased stroke risk with oral hormone therapies, but suggests no increased risk of stroke with transdermal or vaginal estrogen application.

 


 

1 – Use of Alternative Medicine for Cancer and Its Impact on Survival – Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentary: Use of alternative medicine hastens death of cancer patients – Edzard Ernst (free) AND Cancer Survival Takes a Hit with Alternative Medicine – MedPage Today (free) AND Using Alternative Medicine Only for Cancer Linked to Lower Survival Rate – Yale Cancer Center, via NewsWise (free) AND ‘Alternative Medicine’ for Cancer Ups Death Risk – Medscape (free registration required)

 

2 – Free Online Courses Starting Today

– Design and Interpretation of Clinical Trials – Johns Hopkins University and Coursera

– Understanding Clinical Research: Behind the Statistics – University of Cape Town and Coursera

– Public Health in Humanitarian Crises – Johns Hopkins University and Coursera

– Health Across the Gender Spectrum – Stanford University and Coursera

– Major Depression in the Population: A Public Health Approach – Johns Hopkins University and Coursera

– An Introduction to Global Health – University of Conpenhagen and Coursera

– Health Care IT: Challenges and Opportunities – Icahn School of Medicine at Mount Sinai and Coursera

– Leading Healthcare Quality and Safety – The George Washington University and Coursera

– Easing the burden of obesity, diabetes and cardiovascular disease – The University of Sydney and Coursera

– The People, Power, and Pride of Public Health – Johns Hopkins University and Coursera

 

3 – Prevention of suicide with regulations aimed at restricting access to highly hazardous pesticides: a systematic review of the international evidence (free)

Commentaries: Regulatory control of highly hazardous pesticides to prevent self-poisoning – The Lancet Global Health (free) AND Highly hazardous pesticides: policies should focus on bans, rather than secure storage, Lancet studies suggest – Bristol Health Partners (free)

Related: Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial – The Lancet (free) AND Learning from a negative trial of lockable pesticide storage – The Lancet (free)

“A worldwide ban on the use of highly hazardous agricultural pesticides is likely to prevent tens of thousands of deaths every year”.

 

4 – Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis – The Lancet Global Health (free)

Invited commentary: Universal eye health: are we getting closer? (free)

Commentary: Global blindness set to ‘triple by 2050′ – BBC (free) (via Global Health NOW Newslellter)

“Blindness is set to rise at an alarming rate reaching 115 million by 2050” (RT @UniMelbMDHS see Tweet)

 

5 – Guideline: Counseling Adolescents About Contraception – American Congress of Obstetricians and Gynecologists (free)

Commentary: Contraception and adolescents: ACOG releases counseling recommendations for clinicians – Clinical Advisor (free)

 

6 – Severe infections and subsequent delayed cardiovascular disease – European Journal of Preventive Cardiology (free)

Commentary: Pneumonia Or Sepsis in Adults Associated With Increased Risk of Cardiovascular Disease – European Society of Cardiology Press Releases (free) AND Elevated Cardiovascular Risk May Linger for Several Years After a Severe Infection – TCTMD (free) AND CVD risk may rise sixfold in the year after pneumonia, sepsis – Medical News Today (free)

 

7 – Thromboembolic Risk, Bleeding Outcomes and Effect of Different Antithrombotic Strategies in Very Elderly Patients With Atrial Fibrillation: A Sub‐Analysis From the PREFER in AF (PREvention oF Thromboembolic Events–European Registry in Atrial Fibrillation) – Journal of The American Heart Association (free)

Observational study suggests anticoagulation for stroke prevention in patients with atrial fibrillation is beneficial even for very elderly subjects.

 

8 – Sildenafil for pulmonary hypertension in neonates – Cochrane Library (link to summary – $ for full-text)

“Sildenafil may help reduce mortality and improve oxygenation in neonates with pulmonary hypertension” (RT @CochraneUK see Tweet)

 

9 – Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Mite-proof covers may reduce severity of asthma exacerbations in allergic children – News Medical (free)

Source: EvidenceAlerts

 

10 – Treatments for reducing menopausal hot flushes are ranked for effectiveness – NIHR Signal (free)

Original article: Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause – British Journal of Obstetrics and Gynaecology (free)

 


 

1 – The association of depression at any time to the risk of death following coronary artery disease diagnosis – European Heart Journal – Quality of Care and Clinical Outcomes (link to abstract – $ for full-text)

Commentaries: Having depression and heart disease could double death risk – Medical News Today (free) AND Death risk doubles for heart patients with depression – Cardiovascular Business (free)

Related: AAFP Guideline for the Detection and Management of Post–Myocardial Infarction Depression – Annals of Family Medicine (free)

 

2 – Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study – Arthritis Research & Therapy (free)

Commentaries: Gout Patients Run Higher Risk of Kidney Stones – MedPage Today (free registration required) AND Gout associated with elevated risk for kidney stones – MedWire News (free)

“60% increased risk of first-time nephrolithiasis versus general population, with little protection from allopurinol” (from MedPage Today)

 

3 – Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study – The Lancet HIV (free registration required)

Commentaries: PrEP on demand or every day? – The Lancet HIV (free registration required) AND HIV pre-exposure prophylaxis can be taken as needed – Reuters (free)

“four doses of PrEP around the time of sexual activity cut the risk of HIV by 97 percent” (from Reuters Health)

 

4 – Interventions for emergency contraception – Cochrane Library (link to abstract – $ for full-text)

Summary: Methods of emergency contraception (free)

 

5 – Effects of CPAP and Mandibular Advancement Devices on Health-Related Quality of Life in OSA – Chest (free)

See also a recent study showing CPAP does not reduce cardiovascular events in our July 13th issue (see #2)

“CPAP is effective in improving health-related quality of life in OSA, and Mandibular Advancement Devices may be just as effective, but further RCTs comparing the two treatments are required”.

 

6 – Strategies to prevent death by suicide: meta-analysis of randomised controlled trials – British Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Brief Intervention and Contact (BIC) to prevent suicide – Dave Cesarini, via Medium (free)

Related article: Effectiveness of brief intervention and contact for suicide attempters: a randomized controlled trial in five countries – Bulletin of the World Health Organization (free)

Source: Psychiatry Research Review

“The WHO BIC is a promising suicide prevention strategy. No other intervention showed a statistically significant effect in reducing suicide”.

 

7 – Suicide Prevention in an Emergency Department Population: The ED-SAFE Study – JAMA Psychiatry (link to abstract – Free Full Text PDF via @unpaywall)

Commentaries: Intervention Phone Calls May Save The Lives Of Suicidal Patients, Reduce New Attempts, Trial Finds – Medical Daily (free) AND National study shows interventions like telephone calls can reduce suicides – EurekAlert (free) AND Intervention Curbs New Suicide Attempts in At-Risk ED Patients – Medscape (free registration required)

Source: Psychiatry Research Review

Patients who received a multifaceted intervention that included follow-up telephone calls resulted in a 30 percent reduction in future suicide attempts” (from Medical Daily)

 

8 – The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis – The Lancet Public Health (free) (RT @equitylist see Tweet)

Invited commentary: Inequality and intergenerational transmission of complex adversity (free)

Editorial: Our greatest untapped resource (free)

 

9 – Diet and Risk of Cholecystectomy: A Prospective Study Based on the French E3N Cohort – American Journal of Gastroenterology (link to abstract – $ for full-text)

Commentary: Fewer gallbladder surgeries with Mediterranean diets – Reuters (free)

 

10 – Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study – Journal of The American Geriatrics Society (free)

Commentaries: Cognitive decline could be reduced with a Mediterranean-style diet – Medical News Today (free) AND Mediterranean-style diets linked to better brain function in older adults – Journal of the American Geriatrics Society Research Summary (free)

 


 

1 – Developmental follow-up of children and young people born preterm – NICE Guideline (free)

 

2 – Sleep Disorder Diagnosis During Pregnancy and Risk of Preterm Birth – Obstetrics & Gynecology (link to abstract – $ for full-text)

Commentaries: Sleep Disorders in Pregnancy Linked to Preterm Birth – Medscape (free registration required) AND Insomnia linked to premature birth in study of 3 million mothers – Nature News (free)

“Women with sleep disorders were about twice as likely to deliver babies more than six weeks early” (from Nature News)

 

3 – Effect of marijuana use on cardiovascular and cerebrovascular mortality: A study using the National Health and Nutrition Examination Survey linked mortality file – European Journal of Preventive Cardiology (free)

Commentaries: Marijuana associated with three-fold risk of death from hypertension – European Society of Cardiology, via Science Daily (free) AND Marijuana use holds three-fold blood pressure death risk: study – Reuters (free) AND Marijuana Use Tied to Death from Hypertension, Study Suggests – Physician’s First Watch (free) AND Marijuana ‘may be worse than cigarettes for cardiovascular health’ – Medical News Today (free)

 

4 – The verdict: is blogging or tweeting about research papers worth it? – The London School of Economics and Political Science (free) (RT @CLAHRC_West and @CebmOxford)

Researchers can no longer ignore social media.

 

5 – What do hypnotics cost hospitals and healthcare? – F1000 Research (free)

Source: Hospital Medicine Virtual Journal Club

“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.

 

6 – Treating subclinical thyroid dysfunction in pregnancy probably has no benefit – NIHR Signal (free) (RT see Tweet)

Related: Subclinical Hypothyroidism – NEJM Resident 360 (free) AND Levothyroxine Shows No Benefit in Older Adults with Subclinical Hypothyroidism – Physician’s First Watch (free)

“Treating subclinical thyroid dysfunction in pregnancy probably has no benefit” (RT @NIHR_DC see Tweet)

 

7 – Gadolinium deposition in the brain: summary of evidence and recommendations – The Lancet Neurology (free registration required)

Commentaries: Gadolinium deposition: practical guidelines in the face of uncertainty – The Lancet Neurology (free registration required) AND MRI Contrast Agents Accumulate in the Brain – Case Western Reserve University, via NewsWise (free)

 

8 – A systematic review to identify and assess the effectiveness of alternatives for people over the age of 65 who are at risk of potentially avoidable hospital admission – BMJ Open (free) (RT @NIHR_DC)

Alternatives to hospital admission for people aged over 65 years can be safe and reduce costs across a range of acute and chronic conditions.

 

9 – All-Cause and Specific-Cause Mortality Risk After Roux-en-Y Gastric Bypass in Patients With and Without Diabetes (link to abstract – $ for full-text)

Commentary: Gastric Bypass Sharply Lowers Death Risk for People With Diabetes, Study Finds – AJMC (free)

Case-control study suggests the procedure may reduce the risk of death in patients with diabetes.

 

10 – Tai Chi for Risk of Falls. A Meta-analysis – Journal of The American Geriatrics Society (link to abstract – $ for full-text)

Commentaries: Meta-Analysis: Tai Chi Keeps Seniors from Falling – MedPage Today (free registration required) AND Tai chi may help reduce rate of falls in older and at-risk adults – News Medical (free)

‘Can reduce fall rates by almost half during the first year’ (from MedPage Today)

 


 

1 – New NICE Guideline: Fever in under 5s: assessment and initial management (free)

 

2 – Interventions during pregnancy and childbirth for preventing cerebral palsy: an overview of Cochrane reviews (free)

 

3 – Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery – World Journal of Emergency Surgery (free)

 

4 – Prognostic Factors for Treatment Failure in Acute Otitis Media – Pediatrics (link to abstract – $ for full-text)

Commentaries: Features predicting treatment failure in acute otitis media – 2 Minute Medicine (free) AND Study IDs Children With AOM Who Benefit From Antibiotics – Medscape (free registration required)

“Children with severe bulging of the tympanic membrane seem to benefit most from antimicrobial treatment of AOM”

 

5 – Half of papers searched for online are free to read – Nature News (free)

“Large study of open research analysed reader data from Unpaywall tool, which finds freely available versions of articles”.

 

6 – Expansion of Treatment for Hepatitis C Virus Infection by Task Shifting to Community-Based Nonspecialist Providers: A Nonrandomized Clinical Trial – Annals of Internal Medicine (free)

Commentaries: Nonspecialists Could Safely Provide Hepatitis C Care – Physician’s First Watch (free) AND HCV treatment by NPs, PCPs appears safe, effective as that provided by subspecialists – ACP Internist (free)

“Expansion of Treatment for HCV Infection by Task Shifting to Community-Based Nonspecialists” (RT @kennylinafp see Tweet)

 

7 – ANMCO Scientific Statement: clinical management of hypercholesterolaemia in patients with acute coronary syndromes – European Heart Journal (free)

 

8 – Opinion: How Low Is Too Low With Salt in Heart Failure? Randomized Studies Needed to Resolve Concern – Circulation (free)

See more on sodium intake and cardiovascular disease in our July 11th issue (see #1)

 

9 – Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Typical adults eat enough salt to damage heart – Reuters (free) AND High Dietary Sodium Linked to Subclinical Cardiac Dysfunction – Medscape (free registration required)

 

10 – How long should I take antibiotics? Exploring the Goldilocks problem – Robin Centor in KevinMD.com Blog (free)

Related: The antibiotic course has had its day – The BMJ (free) AND Keep taking the tablets: three reasons to stay the full antibiotics course – The Conversation (free) (RT @Onisillos) AND Why you really should take your full course of antibiotics – The Conversation (free)

 


 

1 – Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome: a meta-analysis of randomised trials – The Lancet (link to abstract – $ for full-text)

Commentary: Optimal Timing of an Invasive Strategy in NSTE-ACS Patients – American College of Cardiology, Latest in Cardiology (free)

An early invasive strategy does not reduce mortality compared with a delayed invasive strategy in most patients with NSTE-ACS, but seems to reduce mortality in high-risk patients.

 

2 – Outbreak-Related Disease Burden Associated with Consumption of Unpasteurized Cow’s Milk and Cheese, United States, 2009–2014 – Emerging Infectious Diseases (free)

Commentaries: Raw milk: a superfood or super risky? – The Guardian (free) AND Raw milk and cheese cause 840 times more illnesses than pasteurized products – STAT News (free)

 

3 – State of The Art Review: Advances in the diagnosis of pneumonia in children – The BMJ (free)

 

4 – Longer sleep is associated with lower BMI and favorable metabolic profiles in UK adults: Findings from the National Diet and Nutrition Survey – PLOS One (free)

Commentary: Short sleep linked to body mass, waist size – Reuters Health (free)

 

5 – simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free) (RT @Students4BE see Tweet)

 

6 – Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome – Mayo Clinic Proceedings (free)

Commentaries: Metabolic syndrome: An hour of resistance training per week may cut risk – Medical News Today (free) AND Resistance Training Tied to Lower Risk for Metabolic Syndrome – Physician’s First Watch (free)

 

7 – Factors Associated With Achieving a Body Mass Index of Less Than 30 After Bariatric Surgery – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Opting for Weight-Loss Surgery at Lower BMIs May Be Best for Patients’ Health, Study Suggests – University of Michigan, via NewsWise (free) AND Delayed Weight Loss Surgery Tied to Worse Outcomes – MedPage Today (free registration required) AND Weight-loss surgery may work better when patients aren’t too obese – Reuters (free) AND With bariatric surgery, a patient’s starting weight makes a difference, study finds – STAT (free)

 

8 – Richard Lehman’s journal review, 7 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Review: Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes – BMC Medicine (free)

 

10 – Review: Subclinical thyrotoxicosis: prevalence, causes and choice of therapy – European Journal of Endocrinology (free)

 


 

1 – Guideline: Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition – National Institute for Health and Care Excellence (NICE – UK) (free)

 

2 – Free online courses starting today:

– Community Change in Public Health – Johns Hopkins University and Coursera

– Health for All Through Primary Health Care – Johns Hopkins University and Coursera

– Global Health at the Human-Animal-Ecosystem Interface – University of Geneva and Coursera

– Childbirth: A Global Perspective – Emory University and Coursera

– An Introduction to Population Health – University of Manchester and Coursera

– Global Adolescent Health – University of Melbourne and Coursera 

– Positive Psychiatry and Mental Health – University of Sidney and Coursera

 

3 – ANMCO Position Paper: long-term follow-up of patients with pulmonary thromboembolism – European Heart Journal (free)

 

4 – Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free)

See more on “Deprescribing” in our May 8th issue (see #4), May 9th issue (see #7) and May 15th issue (see #2), and also a related article on Current and future perspectives on the management of polypharmacy (free)

“Yes. Way Too Many Meds. Think De-prescribe”. (RT @EricTopol see Tweet)

 

5 – Design Thinking for Doctors and Nurses – New York Times (10 articles per month are free)

 

6 – Have Smartphones Destroyed a Generation? – The Atlantic (free)

Long read… very interesting.

 

7 – A comprehensive guide to the new science of treating lower back pain – VOX (free)

“Mainstream medicine has failed people with chronic back pain”

 

8 – Modifiable Risk Factors for Incident Heart Failure in Atrial Fibrillation – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentary: Risk for Incident Heart Failure in Atrial Fibrillation – American College of Cardiology, Latest in Cardiology (free)

“Lose weight, treat hypertension & diabetes, stop smoking: That’s how we might prevent heart failure” (RT @JACCJournals see Tweet)

 

9 – 2017 consensus of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation – Journal of Arrhythmia (free)

 

10 – The global crackdown on parents who refuse vaccines for their kids has begun – VOX (free)

See more on mandatory vaccination in our May 29th (see #6) and July 12th (see #5) issues

“Countries like Italy and Australia are tired of measles outbreaks — so they’re moving to fine anti-vaccine parents”.

 


 

1 – Special issue: Public Health Research & Practice – July 2017 Edition

Editorial: Cancer screening: concerns, controversy and evidence (free)

– PSA testing for men at average risk of prostate cancer (free)

– What is overdiagnosis and why should we take it seriously in cancer screening? (free)

– History, development and future of cancer screening in Australia (free)

– Assessing the efficacy of cancer screening (free)

– Improving communication about cancer screening: moving towards informed decision making (free)

“A special issue to check out if you’re interested in cancer screening (including communication)” (RT @hildabast see Tweet)

 

2 – Discover and defeat your diagnostic errors – ACP Internist (free) (RT @acpinternist  see Tweet)

“Experts explain the causes and solutions for common mistakes in diagnosis”.

 

3 – Evidence for Health Decision Making: Beyond Randomized, Controlled Trials – New England Journal of Medicine (free)

Commentary: Why the ‘gold standard’ of medical research is no longer enough – STAT (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

 

4 – Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome – Neurology (link to abstract – $ for full-text)

Commentary: Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition – MPR (free) (RT @AmeshAA see Tweet)

 

5 – A soft robotic exosuit improves walking in patients after stroke – Science Translational Medicine (free)

Commentaries: Robotic Exosuit Improves Walking After Stroke – Medscape (free registration required) AND Watch a robotic exoskeleton help a stroke patient walk – Science (free text and video)

 

6 – Prescribing regular drugs to prevent febrile convulsions risks more harm than benefit – NIHR Signal (free)

Original article: Prophylactic drug management for febrile seizures in children – Cochrane Library (link to summary – $ for full-text)

Benefits of anti-epileptic medication for children who’ve had a convulsion while feverish, do not outweigh harms” (RT @NIHR_DC see Tweet)

 

7 – Utilization of Statins Beyond the Initial Period After Stroke and 1‐Year Risk of Recurrent Stroke – Journal of The American College of Cardiology (free)

Commentary: Quitting statins after stroke may raise risk of another stroke – AHA / ASA Newsroom (free) AND Many Stroke Patients Stop Statins or Never Start, With Dire Consequences – TCTMD (free) AND Stopping statins after stroke may increase second-stroke risk – Reuters (free)

 

8 – Iatrogenesis in Pediatrics – AMA Journal of Ethics (free) (RT @JournalofEthics)

New issue with series of articles exploring strategies clinicians need to know to respond to adverse outcomes.

 

9 – Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines (free)

 

10 – Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Steroid treatment for type of kidney disease associated with increased risk for serious infections – The JAMA Network (free)

Renal outcomes seemed to be less frequent in the group using methylprednisolone (5,9% vs 15,9%), but the trial was stopped early due to a significantly increased risk of serious adverse events with oral methylprednisolone vs placebo (14.7% vs 3.2%, primarily excess infections).

 


 

1 – Correction of a pathogenic gene mutation in human embryos – Nature (free)

Nature News & Views: Biotechnology: At the heart of gene edits in human embryos (free)

Commentaries: Embryo Gene-Editing Experiment Reignites Ethical Debate – Scientific American (free) AND Scientists successfully used CRISPR to fix a mutation that causes disease. This is huge – VOX (free) AND U.S. scientists edit genome of human embryo, but cast doubt on possibility of ‘designer babies’ – STAT (free) AND Human embryos edited to stop disease – BBC (free) AND In Breakthrough, Scientists Edit a Dangerous Mutation From Genes in Human Embryos – The New York Times (10 articles per month are free)

 

2 – Choosing Wisely: An International Campaign to Combat Overuse, with new Top 10 recommendations (free) (RT @ChooseWiselyCA and @CADTH_ACMTS see Tweet with infographic)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

Choosing Wisely has prioritized 10 recommendations for limiting overuse internationally.

 

3 – Guidelines for Drinking-Water Quality: Fourth Edition Incorporating the First Addendum – World Health Organization (free)

 

4 – Neck Pain: Revision 2017 – Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association (free)

 

5 – Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trail bank – Annals of Rheumatic Diseases (link to abstract – $ for full-text) (RT @PhysioMeScience see Tweet)

“Currently, there is no good evidence to support the use of glucosamine for hip or knee OA”

 

6 – Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel (free)

“For most people, treatment was not beneficial and may be harmful. Antibiotic treatment did appear to benefit women in pregnancy and those about to undergo urological surgery”.

 

7 – Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Related guideline: NCCN Guidelines Insights: Antiemesis, Version 2.2017 (free)

Commentaries: Antipsychotic Added to ASCO Antiemetic Guide – MedPage Today (free registration required) AND New Antiemetic Guidelines Issued by ASCO – Medscape (free registration required)

 

8 – Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association (free)

 

9 – ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Peri-operative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery (free)

Summary with 10 key points to remember: Perioperative Myocardial Injury and Infarction After CABG – American College of Cardiology, Latest in Cardiology (free)

 

10 – Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism (free)

 


 

1 – Breastfeeding Week Reports: Tracking Progress for Breastfeeding Policies and Programmes: Global breastfeeding scorecard 2017 – World Health Organization, UNICEF (free PDF) AND Nurturing the Health and Wealth of Nations: The Investment Case for Breastfeeding – World Health Organization, UNICEF (free PDF)

News release: Babies and mothers worldwide failed by lack of investment in breastfeeding – World Health Organization (free)

See also: UNICEF page on breastfeeding (free)

New analysis shows an investment of US$4.70 per newborn could generate US$300 billion in economic gains by 2025.

 

2 – New Series from the Lancet journals: Fungal Infections – Lancet Infectious Diseases (RT @Onisillos see Tweet)

Comment: Recovery from serious fungal infections should be realisable for everyone (free registration required)

– Fungal infections in HIV/AIDS (free registration required)

– Candida and invasive mould diseases in non-neutropenic critically ill patients and patients with haematological cancer (free registration required)

– Emerging issues, challenges, and changing epidemiology of fungal disease outbreaks (free registration required)

– Pulmonary and sinus fungal diseases in non-immunocompromised patients (free registration required)

– Improvement of fungal disease identification and management: combined health systems and public health approaches (free registration required)

– The global problem of antifungal resistance: prevalence, mechanisms, and management (free registration required)

– Immunotherapeutic approaches to treatment of fungal diseases (free registration required)

– Neglected endemic mycoses (free registration required)

“This Series of eight reports brings readers up to date on fungal infections and addresses how fungal infection management can be integrated into health systems in low-income and middle-income countries”

 

3 – New Online Calculator: The Smart Risk Score – European Society of Cardiology (RT @JGrapsa see Tweet)

“The SMART Risk Score is a tool to estimate 10-year risk for recurrent vascular events in patients with manifest cardiovascular disease”

 

4 – Guideline: Intrapartum Management of Intraamniotic Infection – American College of Obstetricians and Gynecologists (ACOG) (free)

Commentary: Guidelines on Intraamniotic Infection Released by ACOG – Medscape (free registration required)

 

5 – Predicting Risk of Serious Bacterial Infections in Febrile Children in the Emergency Department – Pediatrics (link to abstract – $ for full-text)

Commentaries: UK researchers fine-tune diagnostic tool for serious bacterial infections – CIDRAP (free) AND Clinical and biomarker-based diagnostic model identifies serious bacterial infections – 2 Minute Medicine (free)

 

6 – Report: The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering – American Academy of Pediatrics (free)

 

7 – Only Six Nations Have Evaluated Readiness for Global Pandemic – New York Times (10 articles per month are free)

Original Report: From panic and neglect to investing in health security : financing pandemic preparedness at a national level – The World Bank (free PDF)

 

8 – Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women’s Health Initiative Observational Cohort – Cancer Epidemiology, Biomarkers & Prevention (link to abstract – $ for full-text)

Commentary: Gum infections linked to several cancers in women – Reuters (free)

 

9 – A surprising amount of medical research isn’t made public. That’s dangerous – VOX (free)

“When the results of clinical trials aren’t made public, the consequences can be dangerous — and potentially deadly” (RT @Students4BE see Tweet)

 

10 – Internet Searches for Suicide Following the Release of “13 Reasons Why” – JAMA Internal Medicine (free)

Editorial: A Call for Social Responsibility and Suicide Risk Screening, Prevention, and Early Intervention Following the Release of the Netflix Series “13 Reasons Why” (free)

Commentaries: ‘13 Reasons Why’ might have triggered suicide searches online – STAT News (free) AND Is ’13 Reasons Why’ Helping Kids Kill Themselves? – MedPage Today (free registration required) AND Google Searches on Suicide Surge After ’13 Reasons Why’ Release: Study – Newsweek (free) Suicide-Related Internet Searches Elevated After Debut of “13 Reasons Why” – Physician’s First Watch (free)

 


 

1 – Treatment of Latent Tuberculosis Infection: An Updated Network Meta-analysis – Annals of Internal Medicine (free)

Related: Guidelines on the management of latent tuberculosis infection – World Health Organization (free)

 

2 – Efficacy of corticosteroid treatment for severe community-acquired pneumonia: A meta-analysis – American Journal of Emergency Medicine (link to abstract – $ for full-text)

Source: More Evidence That Steroids Are Beneficial in Community-Acquired Pneumonia – Journal Watch ($)

In this meta-analysis of randomized controlled trials in patients with severe community-acquired pneumonia, corticosteroid treatment was associated with reduced in-hospital mortality and length of hospital stay.

 

3 – Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Targeted Temperature Management for 24 vs. 48 Hours After OHCA – American College of Cardiology, Latest in Cardiology (free) AND Longer Induced Cooling Not Better After Cardiac Arrest – MedPage Today (free registration required)

“Small trial shows no advantage to an additional day of cooling” (from MedPage Today)

 

4 – Diagnostic Stewardship – Leveraging the Laboratory to Improve Antimicrobial Use – JAMA (free)

“This Viewpoint discusses the potential benefits and harms of diagnostic stewardship – modifying the ordering, performance, and reporting of diagnostic tests to improve antimicrobial use”

 

5 – Report: Antibiotic Use in the United States, 2017: Progress and Opportunities – Centers for Disease Control and Prevention (free)

Commentary: CDC antibiotics report calls for all-out stewardship efforts – CIDRAP (free)

CDC report: antibiotic stewardship protects patients, saves $, slows antibiotic resistance” (RT @IDSAInfo see Tweet)

 

6 – A ‘perfect storm’ superbug: How an invasive fungus got health officials’ attention – STAT (free)

Related: CDC keeping a watchful eye on Candida auris – CIDRAP (free) AND CDC reports uptick in Candida auris cases – CIDRAP (free)

 

7 – A Dangerous, “Silent Reservoir” For Gonorrhea: The Throat – The New York Times (10 articles per month are free)

See related WHO report on the rising of “Untreatable Gonorrhea” in our July 10th issue (see #1)

“Drug-resistant gonorrhea is increasing. Now scientists say the epidemic is being driven by oral sex”. (RT @NYTHealth see Tweet)

 

8 – Richard Lehman’s journal review, 31 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Really Rapid Review: Paris IAS 2017 – HIV and ID Observations in Journal Watch Blogs (free) (RT @CarlosdelRio7 see Tweet)

Highlights from the latest International AIDS Society meeting.

 

10 – New National Guideline Clearinghouse (NGC) Summaries in Low back, Cervical and Thoracic Spine Disorders with focus on occupational health.

Low Back Disorders – American College of Occupational and Environmental Medicine (free summary from NGC – $ see original guideline in ACOEM website)

Cervical and thoracic spine disorders – American College of Occupational and Environmental Medicine (free summary from NGC – $ see original guideline in ACOEM website)

 


 

1 – World Hepatitis Day (28 July 2017) – World Health Organization Campaign (free)

News release: Eliminate hepatitis: WHO (free)

WHO Updated Factsheets (free): Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D and Hepatitis E

 

2 – Tenofovir reduces mother-to-child hepatitis B transmission – NIHR Signal (free)

Original article: Systematic review with meta-analysis: the efficacy and safety of tenofovir to prevent mother-to-child transmission of hepatitis B virus – Alimentary Pharmacology and Therapeutics (link to abstract – $ for full-text)

 

3 – The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free)

Source: Critical Care Reviews Newsletter (free)

 

4 – “It is like texting at the dinner table”: a qualitative analysis of the impact of electronic health records on patient–physician interaction in hospitals – Journal of Innovation in Health Informatics (free)

Commentary: Doctors frustrated that electronic records steal time from patients – Reuters (free)

Related guideline: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

 

5 – Why you really should take your full course of antibiotics – The Conversation (free)

Commentary against a recent article in the BMJ arguing the antibiotic course has had its day

 

6 – FDA announces comprehensive regulatory plan to shift trajectory of tobacco-related disease, death – U.S. Food and Drug Administration (free)

Commentaries: The FDA just took a radical step to cut nicotine in cigarettes so they’re not addictive – VOX (free) AND FDA Proposes Reducing Nicotine In Cigarettes – NPR (free) AND FDA Targets Cigarettes in Broadening of Fight Against Addiction – Bloomberg (free text and video) AND FDA announces plans to slash nicotine levels in cigarettes – STAT News (free) AND FDA plans to reduce nicotine in cigarettes to non-addictive levels – The Guardian (free)

“Woooow. FDA wants to cut the nicotine in cigarettes to nonaddictive levels. This is a public health power move” (RT @onceuponA see Tweet)

 

7 – Interventions for the prevention of recurrent erysipelas and cellulitis – Cochrane Library (link to summary – $ for full-text)

Commentary: Ongoing Antibiotic Prophylaxis Helps Prevent Cellulitis Recurrence – Medscape (free registration required)

 

8 – Alcohol drinking patterns and risk of diabetes: a cohort study of 70,551 men and women from the general Danish population – Diabetologia (link to abstract – $ for full-text)

Commentaries: Drinking Alcohol 3 to 4 Days a Week Tied to Lowest Risk for Diabetes – Physician’s First Watch (free) AND Moderate drinkers less likely to develop diabetes – OnMedica (free) AND Regular alcohol consumption could cut diabetes risk, study finds  – The Guardian (free) AND Diabetes Risk May Be Lowest Drinking 3 to 4 Days Per Week – Medscape (free registration required)

Observational data suggests moderate alcohol consumption may have a possible protective effect against diabetes.

 

9 – Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis – The Lancet (link to abstract – $ for full-text)

Diclofenac 150 mg/day is the most effective NSAID available at present, but are the cardiac and renal risks worth it? Paracetamol does not seem to work for this condition.

 

10 – Peer review is a black box. Let’s open it up – STAT News (free)

Related commentaries: Exposing peer review – Research Information (free) AND More than just being open: giving control to authors and credit to peer reviewers – F1000Research blog (free) AND The peer-review system for academic papers is badly in need of repair – The Conversation (free) AND Manipulating the peer review process: why it happens and how it might be prevented – LSE Impact of Social Sciences blog (free) AND ‘You never said my peer review was confidential’ — scientist challenges publisher – Nature News (free)

 


 

1 – Application of a Lifestyle-Based Tool to Estimate Premature Cardiovascular Disease Events in Young Adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study – JAMA Internal Medicine (free) (RT @JAMAInternalMed see Tweet)

Commentaries: Healthy Heart Score performed moderately well in assessing cardiovascular disease risk in young adults – 2 Minute Medicine (free) AND Online tool predicts heart risk in young adults – Reuters Health (free)

See Health Heart Score Calculator

“An online calculator may help young people predict their risk of developing heart disease in middle age – in time to make lifestyle changes to minimize their odds of myocardial infarction or stroke” (from Reuters)

 

2 – Long working hours as a risk factor for atrial fibrillation: a multi-cohort study – European Heart Journal (free)

Commentaries: Long working week ‘may increase risk of irregular heartbeat’ – NHS Choices (free) AND Long Workdays May Be Bad for Your Heart – The New York Times (10 articles per month are free) AND Long working hours linked to heightened irregular heart rhythm risk – OnMedica (free)

 

3 – Transcatheter aortic valve implantation for aortic stenosis –NICE Guideline (free)

 

4 – Chronic kidney disease in adults – NICE Quality Standard (free)

Commentary: Give chronic kidney disease patients a statin, doctors urged – OnMedica (free)

 

5 – Low back pain and sciatica in over 16s – NICE Quality Standard (free)

Related guideline: Low back pain and sciatica in over 16s: assessment and management – NICE (free)

 

6 – Big names in statistics want to shake up much-maligned P value – Nature News (free)

“One of scientists’ favorite statistics — the P value — should face tougher standards, say leading researchers”

 

7 – Association of Changing Hospital Readmission Rates With Mortality Rates After Hospital Discharge – JAMA (link to abstract – $ for full-text)

Commentaries: Pushing Hospitals To Reduce Readmissions Hasn’t Increased Deaths – NPR (free) AND Reduction in Hospital Readmission Rate Not Associated With Increased Risk of Death Following Discharge – The JAMA Network (free) AND Lower Readmissions Not Linked to Post-Discharge Mortality Risk – MedPage Today (free registration required) AND Study: Reducing readmissions does not harm patients – Becker’s Hospital Review (free)

 

8 – Temporal trends in sperm count: a systematic review and meta-regression analysis – Human Reproduction Update (free)

Commentaries: Sperm counts among western men have halved in last 40 years: study – The Guardian (free) AND Sperm Concentrations Have Fallen 50% in Western World – Medscape (free registration required)

 

9 – Sugar intake from sweet food and beverages, common mental disorder and depression: prospective findings from the Whitehall II study – Scientific Reports (free)

Commentaries: Too much sugar could increase depression risk in men, study suggests – The Guardian (free) AND High sugar diets linked to heightened depression risk in men – The Independent (free)

Association does not imply causation, but this observational study suggests sugar intake has adverse effects on long-term psychological health.

 

10 – Retrospective analysis of newly recorded certifications of visual impairment due to diabetic retinopathy in Wales during 2007–2015 – BMJ Open (free)

Commentaries: Diabetic sight loss cut by screening, research shows – BBC (free) AND Eye screening linked to fall in sight loss in people with diabetes – NHS Choices (free)

 


 

1 – Opinion: The antibiotic course has had its day – The BMJ (free)

Commentaries: Some Doctors Now Say to Stop Antibiotics When You Feel Better – TIME (free) AND Rule that patients must finish antibiotics course is wrong, study says – The Guardian (free)

“Experts suggest patients should stop taking the drugs when they feel better rather than completing their prescription” (from The Guardian)

 

2 – A Prospective Study on the Effect of Sport Specialization on Lower Extremity Injury Rates in High School Athletes – American Journal of Sports Medicine (link to abstract – $ for full-text)

Commentary: Student Athletes Who Specialize Early Are Injured More Often, Study Finds – NPR (free)

Related Reports: Sports Specialization and Intensive Training in Young Athletes – American Academy of Pediatrics (free) AND Overuse injuries and burnout in youth sports: a position statement from the American Medical Society for Sports Medicine (free)

 

3 – E-cigarette use and associated changes in population smoking cessation: evidence from US current population surveys – The BMJ (free)

Editorial: Rise in e-cigarette use linked to increase in smoking cessation rates (free)

Commentaries: Rise in e-cigarettes linked to rise in smokers quitting, say researchers – The BMJ, via EurekAlert (free) AND Study links rising U.S. e-cigarette use to rise in smokers quitting – Reuters (free) AND Rise in E-Cigarettes Linked to Rise in Smokers Quitting – Scoop Health (free)

Related: The shadow of Big Tobacco looms over e-cigarettes and harm reduction – STAT (free) (“Should we settle for lesser harms?”)

 

4 – Use of Prescription Smoking Cessation Medications After Myocardial Infarction Among Older Patients in Community Practice – JAMA (link to abstract – $ for full-text)

Commentaries: Stop-Smoking Meds Underused in Post-MI Setting – MedPage Today (free registration required) AND Heart attack patients don’t adhere to smoking cessation prescriptions – Cardiovascular Business (free) AND Heart attack patients missing out on smoking cessation drugs – Reuters Health (free)

 

5 – 2017 ACS Quality and Safety Conference: “Strong for Surgery” Shows Promise in Reducing Smoking Rates for Patients Facing Surgery – American College of Surgeons, via NewsWise (free)

“Study suggests big drop in smoking rates when surgeons help patients quit before their operations”.

 

6 – Tobacco Use in Top-Grossing Movies — United States, 2010–2016 – MMWR / CDC (free)

Commentaries: A new CDC report could reignite the debate over Hollywood’s influence on teen tobacco use – VOX (free) AND Health Experts Are Worried About a Huge Rise in Smoking in Movies – TIME (free) AND Tobacco gets more screen shots in blockbuster movies, study shows – New York Times (10 articles per month are free)

Source: Medscape

 

7 – Public Health and Economic Consequences of Vaccine Hesitancy for Measles in the United States – JAMA Pediatrics (free)

Commentaries: Study: Small drop in vaccine uptake can trigger measles outbreak – CIDRAP (free) AND Small decline in MMR vaccination rates could have dramatic effect, experts warn – The Guardian (free)

“A 5% drop in measles, mumps and rubella vaccinations could cause a threefold increase of measles cases, costing the public sector millions, US study shows” (from The Guardian)

 

8 – Contemporary Reviews in Critical Care Medicine: Update in Management of Severe Hypoxemic Respiratory Failure – Chest (free PDF)

 

9 – Report: Finding a Path to Safety in Food Allergy: Assessment of the Global Burden, Causes, Prevention, Management, and Public Policy – National Academies of Sciences, Engineering, and Medicine (free)

Summary: Critical Issues in Food Allergy: A National Academies Consensus Report – Pediatrics (free)

Commentary: Food Allergy: Consensus Report Stresses Diagnostic Accuracy – Medscape (free registration required)

 

10 – The Diagnosis and Treatment of Hemoptysis – Deutsches Ärzteblatt international (free)

Source: Critical Care Reviews Newsletter

 


 

1 – Consolidated Guideline on Sexual and Reproductive Health and Rights of Women Living with HIV – World Health Organization (free)

See also: Executive Summary (free)

 

2 – Update: Interim Guidance for Health Care Providers Caring for Pregnant Women with Possible Zika Virus Exposure – MMWR / CDC (free)

Commentaries: CDC Updates Guidelines on Caring for Pregnant Women with Possible Zika Exposure – Physician’s First Watch (free) AND Updated CDC Guidance on Zika in Pregnancy – Medscape (free registration required)

 

3 – Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football – JAMA (free)

Author interview: Evaluation of Chronic Traumatic Encephalopathy in Football Players (free video)

Commentaries: High Prevalence of Evidence of CTE in Brains of Deceased Football Players – JAMA Network (free) AND Brain disease CTE seen in most football players in large report – STAT News (free) AND 110 N.F.L. Brains – The New York Times (10 articles per month are free) AND Signs of brain disease in 99 percent of ex-NFL players studied: paper – Reuters (free) AND Study: CTE Found In Nearly All Donated NFL Player Brains – NPR (free)

“A neuropathologist has examined the brains of 111 N.F.L. players — and 110 were found to have C.T.E., the degenerative disease linked to repeated blows to the head” (from NYT).

 

4 – Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial – The Lancet (free)

Commentary: Long-Acting Injectable HIV Regimens Show Promise – Physician’s First Watch (free) AND Injections ‘next revolution’ in HIV: study – BBC (free)

 

5 – Brazilian guidelines on prevention of cardiovascular disease in patients with diabetes: a position statement from the Brazilian Diabetes Society (SBD), the Brazilian Cardiology Society (SBC) and the Brazilian Endocrinology and Metabolism Society (SBEM) – Diabetology & Metabolic Syndrome (free)

 

6 – Guidelines for the understanding and management of pain in chronic pancreatitis – Pancreatology (free)

 

7 – Cardiocerebral and cardiopulmonary resuscitation – 2017 update – Acute Medicine & Surgery (free)

Source: Critical Care Reviews Newsletter

 

8 – 2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry (free)

 

9 – Report: WHO MERS-CoV Global Summary and Assessment of Risk – World Health Organization (free PDF)

Commentary: WHO: Hospital outbreaks underscore MERS challenges – CIDRAP (free)

See also: WHO’s Work on Middle East respiratory syndrome coronavirus (MERS-CoV)

 

10 – Comparative effectiveness of high-dose versus standard-dose influenza vaccination on numbers of US nursing home residents admitted to hospital: a cluster-randomised trial – The Lancet Respiratory Medicine (free)

Commentaries: Study: High-dose flu vaccine cuts hospitalizations in nursing home residents – CIDRAP (free) AND High-dose influenza vaccine for nursing home residents reduces hospitalisations – OnMedica (free) AND High Dose Influenza Vaccine Leads to Lower Rate of Hospitalization From Respiratory Illnesses in Nursing Home Residents – University Hospitals Cleveland Medical Center, via NewsWise (free)

 


 

1 – Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults – JAMA Internal Medicine (free)

Invited commentary: Early Orthostatic Hypotension and Orthostatic Intolerance—More Than an Observation or Annoyance (free)

Practice Changing – Orthostatic hypotension within 1 min of standing (rather than at 3 minutes) has greater relation to falls, fracture, syncope, motor vehicle crash, and mortality.

 

2 – Latest European Society of Cardiology Clinical Practice Guidelines Summary Cards are now available (Atrial Fibrillation, Heart Failure, CVD Prevention, Cardio-Oncology – free PDF summaries).

See Complete list:

– Atrial Fibrillation

– Heart Failure

– European CVD Prevention in Clinical Practice

– Cardio-oncology

– Infective Endocarditis    

– Hypertrophic Cardiomyopathy

– Cardiac Pacing & CRT

– Arterial Hypertension

– Diabetes & Pre-Diabetes, CVD

– Valvular Heart Disease  

 

3 – Public health interventions may offer society a return on investment of £14 for each £1 spent – NIHR Signal (free)

Original article: Return on investment of public health interventions: a systematic review – Journal of Epidemiology & Community Health (free)

 

4 – Viewpoint: Inconsistent Guideline Recommendations for Cardiovascular Prevention and the Debate About Zeroing in on and Zeroing LDL-C Levels With PCSK9 Inhibitors – JAMA (free)

Balanced point of view regarding the use of PCSK9 Inhibitors.

 

5 – Update on pediatric sepsis: a review – Journal of Intensive Care (free)

Source: Critical Care Reviews Newsletter

 

6 – Richard Lehman’s journal review, 24 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

7 – Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT News (free)

Related: Protecting interns and other physicians from depression and suicide – STAT News (free)

 

8 – Is cyclobenzaprine useful for pain? – Therapeutics Initiative (free)

“…cyclobenzaprine is a long-acting sedative, not a muscle relaxant, and questioning whether any potential benefits are worth the side effects”. (from TI Newsletter). “If prescribed, a dose of 5 mg at bedtime should be tried first.  Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week”.

 

9 – Canadian Cardiovascular Society and Canadian Pediatric Cardiology Association Position Statement on the Approach to Syncope in the Pediatric Patient (free)

See also: Guidelines Summary: National Guideline Clearinghouse (free)

 

10 – Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma (free)

See also: Guideline Summary: National Guideline Clearinghouse (free)

 


 

1 – Guidelines for the managing advanced HIV disease and rapid initiation of antiretroviral therapy – World Health Organization (free) (RT @greg_folkers see Tweet with infographic)

 

2 – WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection – World Health Organization (free) (RT @equitylist see Tweet)

Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free PDF)

See also: WHO’s Work on Pre-exposure prophylaxis (free resources)

 

3 – Review: Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) (free)

 

4 – Effects of control interventions on Clostridium difficile infection in England: an observational study – The Lancet Infectious Diseases (free)

Invited Commentary: Fluoroquinolone restriction to control fluoroquinolone-resistant Clostridium difficile (free)

“Very important finding! Restricting fluoroquinolones more important than infection control measures to prevent CDI” (RT @sanjaysaint see Tweet)

 

5 – Why cancer is not a war, fight, or battle – CNN (free)

Related: He’s a Fighter – The Atlantic (free)

“Cancer is a process, it’s not a war. No winners or losers. Stop military metaphors”. (RT @lucadf see Tweet)

 

6 – “A misuse of scarce funds”: NHS to end prescription of homeopathic remedies – The Guardian (free)

Related: NHS to ban homeopathy and herbal medicine, as ‘misuse of resources’ – The Telegraph (free) AND NHS plans to scrap homeopathy treatments – BBC (free)

 

7 – Effects of Non–Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: A Systematic Review and Meta‐Analysis – Journal of The American Heart Association (free)

“Among patients with AF and native VHD, NOACs reduce stroke and systemic embolism compared with warfarin”.

 

8 – High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies – Diabetic Medicine (link to abstract – $ for full-text)

Commentary: Screening for Erectile Dysfunction Should Be Routine in Diabetes – Medscape (free registration required)

“Erectile dysfunction 3.5 times more common in diabetes” (RT @kamleshkhunti see Tweet)

 

9 – Diabetic retinopathy: current understanding, mechanisms, and treatment strategies – JCI Insight (free)

“It affects 100 M people WW, but under-diagnosed/treated: excellent review of diabetes retinopathy” (RT @EricTopol see Tweet)

 

10 – The Myth of Drug Expiration Dates – ProPublica (free)

“Hospitals and pharmacies are required to toss expired drugs, no matter how expensive or vital. Meanwhile the FDA has long known that many remain safe and potent for years longer”.

 


 

1 – Report: HIV drug resistance report 2017 – World Health Organization (free)

News release: WHO urges action against HIV drug resistance threat (free)

Commentaries: HIV drug resistance could undermine progress in AIDS battle: WHO – Reuters (free) AND Drug-Resistant HIV Is On the Rise – TIME (free)

 

2 – Report: Ending AIDS: Progress Towards the 90-90-90 Target – Joint United Nations Programme on HIV/AIDS (UNAIDS) (free PDF)

Fact Sheet: Latest Statistics on The Status of The Aids Epidemic – UNAIDS (free) (RT @greg_folkers see Tweet)

Related editorial: The global HIV/AIDS epidemic—progress and challenges – The Lancet (free)

Commentary: For first time in history, half of all people with HIV are getting treatment – Science (free) (source: GlobalHealthNOW newsletter)

 

3 – Parkinson’s disease in adults – National Institute for Health and Care Excellence (NICE) Guideline (free)

 

4 – Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Adjusting Antiplatelet Regimen Could Decrease Risk For Stroke Patients on Aspirin Monotherapy – American College of Cardiology, Latest in Cardiology (free)

Meta-analysis of cohort studies: in patients who experienced an ischemic stroke or transient ischemic attack while on aspirin monotherapy, the addition of or a switch to another antiplatelet agent, versus aspirin monotherapy, was associated with a 32 percent reduction in the risk of major adverse cardiovascular events (HR 0.68; 0.54–0.85) and 30 percent reduction in recurrent strokes (HR, 0.70; 0.54–0.92). Additional randomized trials would better clarify the best antiplatet regimen for these patients.

 

5 – Antidepressants during pregnancy and autism in offspring: population based cohort study – The BMJ (free)

Editorial: Prenatal antidepressant use and risk of autism (free)

Commentaries: Antidepressants and pregnancy: study didn’t find they actually cause autism – The Conversation (free) AND Antidepressant use in pregnancy linked to autism in children – OnMedica (free) AND Study finds slight autism risk link to antidepressants in pregnancy – Reuters (free)

 

6 – Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials – The BMJ (free)

Editorial: Diet and exercise in pregnancy (free)

Commentaries: Risk of caesarean reduced by healthy diet and physical activity during pregnancy, study finds – NewsMedical (free) AND C-Section Risk Reduction Linked to Healthy Lifestyle – MedPage Today (free)

 

7 – The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

Commentary: Bystander CPR Best Hope for Out-of-Hospital Cardiac Arrest? – Medscape (free registration required)

See related article on Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest in our May 4th issue (see #2)

 

8 – Report: Dementia prevention, intervention, and care – The Lancet (free registration required)

Commentaries: Experts: 1 in 3 cases of dementia preventable, nonmedical therapies ideal for dementia – University of Southern California, via EurekAlert (free) AND One Third of Dementia May Be Preventable With Lifestyle Change – Medscape (free registration required) AND Over a Third of Dementia Cases Tied to Modifiable Risk Factors – Physician’s First Watch (free) AND Living healthily, learning more could cut dementia cases by a third – Reuters (free) AND Lifestyle changes could prevent a third of dementia cases, report suggests – The Guardian (free)

 

9 – The Uncertain Future of Genetic Testing – The Atlantic (free)

“Bringing genetics into medicine leads to more accuracy, better diagnosis, and personalized treatment—but for some, gene testing has only resulted in unanswered questions”.

 

10 – An emergency department protocol to restore circulation doesn’t improve outcomes in septic shock – NIHR Signal (free)

Original article: Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis – New England Journal of Medicine (link to abstract – $ for full-text)

 


 

1 – WHO report on the global tobacco epidemic 2017 – World Health Organization (free)

Full report: WHO Report on The Global Tobacco Epidemic: 2017 Monitoring tobacco use and prevention policies (free PDF)

Press release: WHO report finds dramatic increase in life-saving tobacco control policies in last decade (free)

Infographics: Protecting people from tobacco (free)

Commentaries: Taxation: Most effective but still the least-used tobacco control measure, by Patricio V. Marquez via The World Bank Blogs (free) AND Tobacco industry blocking anti-smoking moves: WHO – Reuters (free) AND Tobacco firms ‘hamper anti-smoking push’ – BBC News (free) AND Tobacco companies interfere with health regulations, WHO reports – The Guardian (free)

See also our coverage of World No Tobacco Day in our May 31 issue (see #1).

 

2 – Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa – New England Journal of Medicine (free)

Editorial: The Enduring Challenge of Advanced HIV Infection (free)

Among HIV-infected patients with advanced immunosuppression (CD4+ count < 100 cells/mm3), enhanced antimicrobial prophylaxis combined with ART resulted in reduced rates of death.

 

3 – Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: High-dose spironolactone didn’t affect acute heart failure outcomes – ACP Hospitalist (free) AND High-Dose Spironolactone in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free)

 

4 – Use of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study – British Journal of Pharmacology (link to abstract – $ for full-text)

Commentary: New study finds link between certain antibiotics during pregnancy and risk for birth defects – News Medical (free)

Related article: Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free)

In this large canadian cohort clindamycin, doxycycline, quinolones, macrolides, and phenoxymethylpenicillin were associated with congenital malformations. Amoxicillin, cephalosporins, and nitrofurantoin were not associated with birth defects.

 

5 – Position statement: American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs (free PDF)

Commentaries: ASCO Offers Path to Addressing Affordability of Cancer Drugs in New Position Statement – ASCO Post (free) AND ASCO Tackles Affordability of Cancer Drugs – Physician’s First Watch (free) AND ASCO Advocates Value in Drug Pricing – MedPage Today (free registration required) AND ASCO Addresses High Cost of Cancer Drugs – Medscape (free registration required)

 

6 – Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force – Annals of Rheumatic Diseases (free)

Commentary: International Guidelines Say Use Treat-to-Target for SpA, PsA – Medscape (free registration required)

 

7 – Clinical Review: Community-associated methicillin-resistant Staphylococcus aureus infection: Literature review and clinical update – Canadian Family Physician (free)

 

8 – The Aging Physician and the Medical Profession: A Review – JAMA Sugery (free) (RT @EricTopol see Tweet)

 

9 – New Choosing Wisely Canada List: Hepatology: Five Things Physicians and Patients Should Question (free) (RT @ChooseWiselyCA see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6).

 

10 – Improving people’s health through spatial planning – Public Health England (free) (RT @pash22 see Tweet)

Related reports: Spatial planning for health: evidence review – Public Health England (free) AND Healthy people healthy places evidence tool: Evidence and practical linkage for design, planning and health – University of the West of England (free)

Related WHO Report: Preventing disease through healthy environments: a global assessment of the burden of disease from environmental risks (free) AND News release: An estimated 12.6 million deaths each year are attributable to unhealthy environments (free)

 


 

1 – Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Some Plant-Based Diets May Increase Heart Disease Risk –American College of Cardiology, Latest in Cardiology (free) AND Not All Vegetarian, Plant-Based Diets Equal for CHD Risk – Medscape (free registration required) AND Not all plant-based diets are created equal – American College of Cardiology, via ScienceDaily (free)

 

2 – Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection – JAMA Pediatrics (free)

Commentaries: Zika: Check All Potentially Exposed Infants for Eye Damage – Medscape (free registration required) AND Which Infants Exposed to Zika Virus Infection in Pregnancy Should Have Eyes Examined? – The JAMA Network (free)

“All infants with potential Zika virus exposure should have ophthalmic screening regardless of other abnormalities” (RT @PreetiNMalani see Tweet)

 

3 – The Association Between Vasectomy and Prostate Cancer: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Meta-Analysis: Vasectomy Likely Does Not Cause Prostate Cancer – Physician’s First Watch (free) AND Weak Link Between Vasectomy, Prostate Cancer – MedPage Today (free registration required)

 

4 – Draft Recommendation Statement: Ovarian Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Again Recommends Against Screening General Population for Ovarian Cancer – Physician’s First Watch (free) AND USPSTF Stays Course on Ovarian Cancer Screening: No screening for asymptomatic women – MedPage Today (free registration required)

 

5 – Review: Emerging arboviruses: Why today? – One Health (free) (RT @greg_folkers see Tweet)

 

6 – Cochrane What is the best medication for a fungal infection of the toenail? – Cochrane Library (free)

Full review: Oral antifungal medication for toenail onychomycosis – Cochrane Library (link to abstract – $ for full-text)

Terbinafine probably leads to better cure rates than azoles, with the same risk of adverse events. Griseofulvin is no better and has more adverse effects than azoles.

 

7 – Homepage – New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

New available guidelines are:

– Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Newly diagnosed and relapsed mantle cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours (free)

– Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (free)

– Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

 

8 – Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Tapering long-term opioid therapy may improve outcomes in chronic pain, review finds – ACP Internist (free) AND Opioid Reduction Therapy Offers Some Benefits to Patients with Chronic Pain – Physician’s First Watch (free) AND How tapering off opioids can help people with chronic pain – CNN (free)

“Opioid tapering:

– less pain: 8 of 8 studies

– Improved function: 5 of 5 studies

– Improved QOL: 3 of 3 studies” (RT @DavidJuurlink see Tweet)

 

9 – As Workouts Intensify, a Harmful Side Effect Grows More Common – New York Times (10 articles per month are free)

Related practical review: Exercise-Induced Emergencies in the Heat: Rhabdomyolysis & Exertional Heat Stroke – emDocs (free)

 

10 – Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery – British Journal of Surgery (link to abstract – $ for full-text)

Source: ACP Journal Club ($ resource to find articles of interest)

In this RCT, a comprehensive preoperative geriatric assessment and optimization before vascular surgery was associated with shorter length of hospital stay, lower incidence of complications, and patients were less likely to be discharged to a higher level of dependency.

 


 

1 – Report: Progress and Challenges with Achieving Universal Immunization Coverage: 2016 Estimates of Immunization Coverage – WHO / UNICEF (free PDF)  (RT @WHO see Tweet )

News Release: 1 in 10 infants worldwide did not receive any vaccinations in 2016 – World Health Organization (free)

 

2 – Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies – Canadian Medical Association Journal (free)

Commentaries: Artificial Sweeteners Not Tied to Lower BMI and May Even Increase It – Physician’s First Watch (free) AND Artificial Sweeteners Don’t Help People Lose Weight, Review Finds – NPR (free) AND The Irony Of Artificial Sweeteners – Forbes (free) AND Low-calorie sweeteners don’t help with weight loss — and may lead to gained pounds – STAT News (free)

 

3 – What proportion of health outcomes are attributable to health care – Sheffield DPH (free) (RT @gmacscotland and @felly500 see Tweet)

 

4 – The hidden truth about our prescription medications – Ideas.Ted.Com (free)

“Around half of the clinical trials that were done on the medicines we use today have never published their results…” (RT @Students4BE see Tweet)

 

5 – Why are these countries the most obese? Walking is just one reason – CNN (free) (RT @kamleshkhunti see Tweet)

Related studies: Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free) AND NIH-funded team uses smartphone data in global study of physical activity – NIH News Release (commentary, see original article$)

 

6 – Position Statement: American Association of Clinical Endocrinologists And American College Of Endocrinology Position Statement On Menopause – 2017 Update (free)

Related Position Statement: The 2017 hormone therapy position statement of The North American Menopause Society (free PDF)

Related Draft Recommendation Statement: Menopausal Hormone Therapy: Primary Prevention of Chronic Conditions – U.S. Preventive Services Task Force (free)

 

7 – Richard Lehman’s journal review, 17 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Evidence-based guidelines for fall prevention in Korea – The Korean Association of Internal Medicine and The Korean Geriatrics Society (free)

 

9 – Financing transformative health systems towards achievement of the health Sustainable Development Goals: a model for projected resource needs in 67 low-income and middle-income countries – The Lancet Global Health (free) (RT @LancetGH see Tweet)

Invited commentaries: Financing health systems to achieve the health Sustainable Development Goals (free) AND All roads lead to universal health coverage, by Tedros Adhanom Ghebreyesus, Director-General of WHO (free)

WHO News Release: WHO estimates cost of reaching global health targets by 2030 (free)

Commentaries: Global health price tag could be $371 billion a year by 2030, WHO says – Reuters (free)

 

10 – New research program and website: Access to Healthcare – Economist Intelligence Unit (all resources are free) (RT @anetrid see Tweet)

Report: Global access to healthcare: Building sustainable health systems – Economist Intelligence Unit report (free)

“This research programme, created by The Economist Intelligence Unit, examines the challenges and opportunities countries face as they attempt to improve access to high-quality healthcare that meets the needs of their populations. It consists of the Global Access to Healthcare Index, covering 60 countries with a diversity of income levels; a global report; an animated infographic introducing the key findings from the index; six infographics on the main domains of the index; and five regional summary papers”.

 


 

1 – The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines – World Journal of Emergency Surgery (free)

Related guideline: The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections (free)

 

2 – Constipation in children and young people: diagnosis and management – National Institute for Health and Care Excellence (NICE) Guideline (free)

 

3 – High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis – Critical Care (free)

Source: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)

 

4 – Systematic review: Antiepileptic drug monotherapy (single drug treatment) for epilepsy – Cochrane Library (free)

Original article: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data (link to summary – $ for full-text)

 

5 – Studies suggest apneic oxygenation reduces hypoxemia during emergency intubation:

Meta-analysis 1: Apneic oxygenation during intubation in the emergency department and during retrieval: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

Meta-analysis 2: Apneic oxygenation reduces the incidence of hypoxemia during emergency intubation: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full text)

Source: Apneic Oxygenation Prevents Desaturation During Intubation – Journal Watch ($ resource to find articles of interest)

 

6 – Risk of post-pregnancy hypertension in women with a history of hypertensive disorders of pregnancy: nationwide cohort study – The BMJ (free)

Related article: Lifestyle in progression from hypertensive disorders of pregnancy to chronic hypertension in Nurses’ Health Study II: observational cohort study – The BMJ (free)

Editorial: Hypertensive disorders of pregnancy – The BMJ (free)

Commentaries: Hypertensive Disorders of Pregnancy Tied to Increased Hypertension Risk Decades Later – Physician’s First Watch (free)

 

7 – How to spot a misleading graph, by Lea Gaslowitz – TED Talks (free YouTube video)

“How to spot a misleading graph – Great video by Lea Gaslowitz @TEDTalks” (RT @CochraneUK see Tweet)

 

8 – Opinion: Physicians need to openly discuss medical mistakes and near misses – STAT News (free) (RT @statnews see Tweet)

 

9 – “Pathologists debating their future in the era of #AI” (RT @EricTopol see Tweet)

Editorial 1: AlphaGo, Deep Learning, and the Future of the Human Microscopist – Archives of Pathology & Laboratory Medicine (free)

Editorial 2: Artificial Intelligence and the Pathologist: Future Frenemies? – Archives of Pathology & Laboratory Medicine (free)

See more on the impact of artificial intelligence in healthcare in our June 14th issue (see #2 and #3)

 

10 – A must read perspective on “Machine Learning and Prediction in Medicine — Beyond the Peak of Inflated Expectations” – Cross Invalidation (free) (RT @pash22 see Tweet)

 


 

1 – Follow-up of Prostatectomy versus Observation for Early Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Long-term, surgery for localized prostate cancer offers little extra benefit – Reuters (free) AND No Benefit with Surgery for Low-Risk Prostate Cancer – MedPage Today (free registration required) AND Prostatectomy for Localized Prostate Cancer Doesn’t Improve Long-Term Survival – Physician’s First Watch (free) AND Surgery for Early Prostate Cancer May Not Save Lives – Washington University in St. Louis, via NewsWise (free)

“Most men just as likely to survive with limited or no treatment” (from NewsWise)

 

2 – Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and Society of American Gastrointestinal and Endoscopic Surgeons (free)

See other Enhanced Recovery After Surgery (ERAS) Guidelines and Reviews in our collection and in the ERAS Society Website.

 

3 – Clinical Guidelines for the Management of Adrenal Incidentaloma – Endocrinology and Metabolism (free)

 

4 – Association of Changes in Diet Quality with Total and Cause-Specific Mortality – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Improvement in diet quality linked to decreased all-cause mortality – 2 Minute Medicine (free) AND Improving Diet Over Time May Reduce Risk of Death – MedPage Today (free registration required) Change in Diet Can Lower Mortality Risk – Medscape (free registration required) AND Eating a Little Bit Healthier Helps You Live Longer – TIME (free) AND A Range of Healthy Dietary Changes Could Help You Live Longer – Physician’s First Watch (free)

 

5 – Insulin pumps not much better than multiple injections for intensive control of type 1 diabetes – NIHR Signal (free)

Original article: Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE) – The BMJ (free)

 

6 – Editorial: WHO downgrades status of oseltamivir – The BMJ (free)

@WHO downgrades status of oseltamivir. BMJ editorial discusses important lessons from the Tamiflu story” (RT @bmj_latest  see Tweet)

 

7 – Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition (free)

 

8 – Enuresis: practical guidelines for primary care – British Journal of General Practice (free)

 

9 – Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease – Cochrane Library (free)

NIV reduces mortality and endotracheal intubation in patients with acute hypercapnic respiratory failure secondary to an acute exacerbation COPD.

 

10 – Perspectives: Threats to Information Security: Public Health Implications – New England Journal of Medicine (free)

See related articles on Cybersecurity and Health in our June 8th issue (see #5)

 


 

1 – Report: Progress on drinking water, sanitation and hygiene – World Health Organization (free)

News release: 2.1 billion people lack safe drinking water at home, more than twice as many lack safe sanitation (free)

“New WHO/UNICEF report: 2.1 billion ppl lack safe drinking water at home, more than 2x as many lack safe sanitation” (RT @WHO see Tweet with Infographics)

 

2 – Association of Positive Airway Pressure With Cardiovascular Events and Death in Adults With Sleep Apnea: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: More Doubt Cast on CPAP for Reducing CVD Risk in Sleep Apnea Patients – MedPage Today (free registration required) AND Positive airway pressure doesn’t reduce heart risk with sleep apnea – Reuters (free)

“PAP for obstructive sleep apnea improves quality of life but not CV events or BP with up to 5 years of follow up” (RT @AnilMakam see Tweet)

 

3 – State of The Art Review: Advances in the causes and management of community acquired pneumonia in adults – The BMJ (free)

 

4 – Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke – European Heart Journal (link to abstract – $ for full-text)

Commentary: Blood Pressure and Outcomes After Ischemic Stroke – American College of Cardiology, Latest in Cardiology (free)

Related article: Editorial: Blood Pressure in Acute Stroke Still No Answer for Management – Stroke (free PDF)

Observational analysis of over 300.000 patients suggests a J-shaped, or U-shaped relationships between BP and outcomes (both lower and higher BP levels are probably detrimental). Among patients submitted to thrombolytic therapy, there were fewer complications with lower blood pressure.

 

5 – Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Study Compares Switching Meds vs an Additional Med for Patients Unresponsive to an Antidepressant – The Jama Network (free) AND For Treatment-Resistant Depression, Add an Antipsychotic or Switch Antidepressants? – Physician’s First Watch (free)

Augmentation with aripiprazole led to a modestly increased likelihood of remission, but with more adverse effects. “Given the small effect size and adverse effects associated with aripiprazole, further analysis including cost-effectiveness is needed to understand the net utility of this approach”.

 

6 – Association Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral Prednisolone – JAMA (link to abstract – $ for full-text)

Commentaries: Alendronate Cuts Hip-Fracture Rates in High-Risk Elderly – Medscape (free registration required) AND Alendronate helps cut hip fracture risk with prednisolone – OnMedica (free) AND Alendronate Might Help Protect Against Hip Fracture in Patients Taking Prednisolone – Physician’s First Watch (free)

Retrospective cohort suggests alendronate might reduce fracture risk in the short term in elderly patients taking prednisolone.

 

7 – Large-scale physical activity data reveal worldwide activity inequality – Nature (link to abstract and free graphics – $ for full-text)

Commentaries: NIH-funded team uses smartphone data in global study of physical activity – NIH News Release (free) AND Do you live in the world’s laziest country? – BBC News (free)

 “Big data in action! Scientists analyzed smartphone data from 700k+ ppl&100 countries to study physical activity” (RT @NIHDirector see Tweet)

 

8 – Summary with 10 key points to remember: Diagnosis and Management of Resistant Hypertension – American College of Cardiology, Latest in Cardiology (free)

Original article: Diagnosis and management of resistant hypertension – Heart (link to abstract – $ for full-text)

 

9 – Meta-analysis: Safety and Efficacy of Dual Versus Triple Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention – American Journal of Medicine (link to abstract – $ for full-text)

Source: EvidenceAlerts (free resource to find articles of interest)

“In patients receiving anticoagulant therapy, a strategy of single antiplatelet therapy confers a benefit of less major bleeding with no difference in all-cause mortality, cardiovascular mortality, major adverse cardiac events, myocardial infarction, stent thrombosis, or thromboembolic event rate compared with dual antiplatelet therapy”.

 

10 – Beverage Intake During Pregnancy and Childhood Adiposity – Pediatrics (free)

Commentaries: Consumption of sugar sweetened beverages during pregnancy linked to childhood obesity – 2 Minute Medicine (free) AND Drinking sugary beverages in pregnancy linked to kids’ later weight gain – Science News (free)

 


 

1 – Association of Coffee Consumption With Total and Cause-Specific Mortality Among Nonwhite Populations – Annals of Internal Medicine (link to abstract – $ for full-text)

Related study: Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: No, These Two Studies Don’t Prove That Coffee Leads To Longer Life – Forbes (free) AND Coffee cuts risk of dying from stroke and heart disease, study suggests – The Guardian (free) AND Drinking coffee reduces risk of death from all causes, study finds – Imperial College of London (free)

 

2 – Behavioral Counseling to Promote a Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Cardiovascular Risk Factors: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorial 1: Healthful Physical Activity and Diet Promotion—For the Many or the Few? (free)

Editorial 2: Cardiovascular Risk Factor Control for All (free)

Editorial 3: Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Known Risk Factors: Is Behavioral Counselling Necessary? (free)

The JAMA Network – For The Media: USPSTF Recommendation Regarding Behavioral Counseling for Cardiovascular Disease Prevention (free)

 

3 – Palliative Care in Heart Failure: The PAL-HF Randomized, Controlled Clinical Trial (link to abstract – $ for full-text)

Commentaries: Palliative Care Intervention Improves Quality of Life in Advanced Heart Failure Patients – American College of Cardiology, Latest in Cardiology (free) AND Palliative Care Improves Heart Failure Quality-of-Life – MedPage Today (free registration required)

 

4 – The weird power of the placebo effect, explained – VOX (free)

Related: Placebos can work even when patients know what they are – World Economic Forum (free)

 

5 – France is making 11 vaccines mandatory to fight against preventable disease – World Economic Forum (free)

Related: Editorial: The Guardian view on vaccinations: a matter of public health (free)

Related 2: A short history of vaccine objection, vaccine cults and conspiracy theories – The Conversation (RT @Onisillos see Tweet)(free)

See more on mandatory vaccination in other countries in our May 29 issue, see #6

 

6 – Association of delay of urgent or emergency surgery with mortality and use of health care resources: a propensity score–matched observational cohort study – Canadian Medical Association Journal (free)

Commentary: Patients whose emergency surgery is delayed are at higher risk of death – Canadian Medical Association Journal, via EurekAlert (free)

Source: STAT News Newsletter

Delayed operating room access for emergency surgery was associated with increased risk of in hospital mortality, longer length of stay and higher costs”.

 

7 – Doxycycline may be a safer first option for treating a blistering skin condition – NIHR Signal (free)

Original Article: Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial – The Lancet (free) AND Editorial: Doxycycline: a first-line treatment for bullous pemphigoid? (free)

 

8 – Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study – The Lancet (link to abstract – $ for full-text)

Commentaries: More reason to use Meningococcal B vaccine – it could also cut the Clap – The Conversation (author’s commentary – free) AND Meningococcal Vaccine May Provide Immunity Against Gonorrhea – Medscape (free registration required) AND Meningitis vaccine may also cut risk of ‘untreatable’ gonorrhoea, study says – The Guardian (free)

See related articles on the rising of “Untreatable” gonorrhea in our July 10th issue (see #1)

 

9 – Suturing a divided world: How providing access to surgery drives global prosperity – The Conversation (free)

Related: Essential Surgery – Disease Control Priorities (DCP3) (free landmark book on the topic) AND The Lancet Commission on Global Surgery (free resources)

Source: Global Health NOW Newsletter

 

10 – Electrocardiograms in Low-Risk Patients Undergoing An Annual Health Examination – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: More than 20% of low-risk patients receive an ECG as part of annual health exam –  Institute for Clinical Evaluative Sciences (ICES) (RT @ICESOntario and @ChooseWiselyCA see Tweet) (free) AND ECGs Common in Low-Risk Patients After Annual Health Exam, Leading to More Cardiac Care – American College of Cardiology, Latest in Cardiology (free) Routine ECG With Annual Physical Questioned – MedPage Today (free registration required)

 


 

1 – Salt intake and Cardiovascular Disease – European Heart Journal (free)

Full report: The technical report on sodium intake and cardiovascular disease in low- and middle-income countries by the joint working group of the World Heart Federation, the European Society of Hypertension and the European Public Health Association (free)

Commentary: CardioBrief: Int’l Experts Call Sodium Guidelines Far Too Restrictive – MedPage Today (free registration required)

Summary of the technical report on sodium intake and cardiovascular disease with key recommendations for individuals and policymakers.

 

2 – Management of Small Renal Masses: American Society of Clinical Oncology Clinical Practice Guideline (free)

Summary: National Guideline Clearinghouse (free)

 

3 – Women with High-Risk Pregnancies Are More Likely To Develop Heart Disease – NPR (free)

Related review: Adverse Pregnancy Conditions, Infertility, and Future Cardiovascular Risk: Implications for Mother and Child – Cardiovascular Drugs and Therapy (free)

 

4 – Just Started! Free Online Course. Science of Exercise – University of Colorado Boulder and Coursera

 

5 – Just Started! Free Online Course. Health for All Through Primary Health Care – Johns Hopkins University and Coursera

 

6 – Effective Care for High-Need Patients: Opportunities for Improving Outcomes, Value, and Health (free PDF)

See also: News release (free) AND Executive summary (free PDF) AND Key Points (free PDF) AND Characteristics of Successful Care Models for High-Need Patients (free PDF)

Commentary: New NAM publication examines improving outcomes, reducing costs for ‘high-needs patients’ – National – National Academies of Sciences, Engineering, and Medicine, via EurekAlert (free)

See more resources on high-need, high-cost patients in our July 4th issue (see #2)

Source: STAT News Newsletter

“Nearly half of the nation’s spending on health care is driven by 5 percent of patients, and improving health outcomes and curbing spending in health care will require identifying who these high-needs patients are and providing coordinated services” (from EurekAlert)

 

7 – Richard Lehman’s journal review / 10 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Rivastigmine reviewed: doubts about dementia drug – Evidently Cochrane (free)

Related review: Rivastigmine for people with Alzheimer’s disease – Cochrane Library (link to abstract – $ for full-text)

“”Sadly, “small” and “of uncertain clinical importance” are the words chosen by the Cochrane reviewers to describe…” (RT @CochraneUK see Tweet)

 

9 – Cochrane Review: Gabapentin for chronic neuropathic pain in adults – Cochrane Library (link to abstract – $ for full-text)

Commentary: Analgesic Effects of Gabapentin Assessed in Chronic Neuropathic Pain – MPR (free)

“Gabapentin at doses of 1800 mg to 3600 mg daily (1200 mg to 3600 mg gabapentin enacarbil) can provide good levels of pain relief to some people with postherpetic neuralgia and peripheral diabetic neuropathy”.

 

10 – The rise of antibiotic-resistant infections threaten economies – Finantial Times (a few articles per month are free) (RT @greg_folkers see Tweet)

Related report: Drug-Resistant Infections: A Threat to Our Economic Future – World Bank (Free PDF) AND Infographic: Drug Resistant Infections: A Threat to Our Economic Future (free) AND News Release: By 2050, drug-resistant infections could cause global economic damage on par with 2008 financial crisis (free)