Fri, June 23 – 10 Stories of The Day!

23Jun
2017

 

1 – WHO Framework on integrated people-centered health services (free resources)

Video: WHO – What is people-centered care? And why does it matter? Our new video explains! (free) (RT @WHO see Tweet)

“Integrated people-centered health services means putting the comprehensive needs of people and communities, not only diseases, at the center of health systems, and empowering people to have a more active role in their own health”.

 

2 – Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: The Head Position in Stroke Trial (free)

Commentary: Head Positioning During Early Stroke Treatment Apparently Doesn’t Affect Outcome – Physician’s First Watch (free)

 

3 – Review: Radiation Associated Cardiac Disease – American College of Cardiology, Latest in Cardiology (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)

 

4 – Why We Overrate the Lifesaving Power of Cancer Tests – Scientific American (free) (RT @EricTopol see Tweet)

 

5 – Continuous positive airway pressure for children with undifferentiated respiratory distress in Ghana: an open-label, cluster, crossover trial – The Lancet Global Health (free)

Invited commentary: Every breath you take… (free)

Commentary: CPAP improves respiratory and survival rates in children in Ghana – Columbia University’s Mailman School of Public Health, via EurekAlert (free)

 

6 – Breastfeeding and the Risk of Maternal Cardiovascular Disease: A Prospective Study of 300 000 Chinese Women – Journal of the American College of Cardiology (free)

Commentaries: Mother’s heart health tied to breastfeeding – Reuters Health (free) Does breastfeeding prevent heart disease and strokes? – STAT News (free) AND Breastfeeding could help a mother’s heart – in more ways than you think – American Heart Association News (free)

Observational data suggests there may be a protective effect.

 

7 – Cardiopulmonary resuscitation – 30:2 or just keep going? – by Scott Munro, in Evidently Cochrane (free) (RT @NIHR_DC see Tweet)

“Untrained bystander CPR had better outcomes when given telephone advice from EMS services to perform continuous CPR, rather than interrupted CPR with rescue breaths”. For trained EMS professionals, “it is possible that there is little or no difference between the two approaches”.

 

8 – An update on Zika virus infection – The Lancet (free registration required)

“Update on Zika virus infection (2017): review focuses on important updates & gaps in the knowledge” (RT @TheLancet see Tweet)

 

9 – WHO toolkit for the care and support of people affected by complications associated with Zika virus – World Health Organization (free)

 

10 – Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non-inferiority trial – Medical Journal of Australia (link to abstract – Free PDF here) (RT @theMJA see Tweet)

Author commentaries: Emergency doctors are using acupuncture to treat pain, now here’s the evidence – The Conversation (free)

Positive commentaries: Acupuncture Found to Be an Effective Analgesia Option in ER – PracticeUpdate (free registration required) AND Acupuncture relieves pain in emergency patients: Study – RMIT University, via ScienceDaily (free)

“Not so fast” commentaries: Acupuncture in the ER: No, study did not prove it was ‘safe and effective’ – HealthNewsReview (free) AND A skeptical look at a study of acupuncture delivered in emergency rooms, by James C Coyne (free)

 

Thu, June 22 – 10 Stories of The Day!

22Jun
2017

 

1 – Every Newborn Action Plan – World Health Organization (free) (RT @WHO see Tweet with infographic)

Related report from UK: Each Baby Counts – Royal College of Obstetricians and Gynaecologists (free PDF) Each Baby Counts Homepage (free resources) AND Reducing baby deaths and brain injuries during childbirth – BBC News (free)

Every year, 2.7 million babies die in the first 28 days of life. 75% of these deaths are preventable.

 

2 – WHO bids goodbye to Dr Chan and celebrates her achievements – World Health Organization (Source: WHO Newsletter)

Report 1: Ten years of transformation: Making WHO fit for purpose in the 21st century (free)

Report 2: Ten years in public health 2007-2017 (free)

Report 3: Healthier, fairer, safer: the global health journey 2007–2017 (free)

Related: My decade leading the WHO: dirty fights and steps toward universal coverage – by By Margaret Chan, Via STAT News (free)

“As Dr Margaret Chan’s term as Director-General of WHO comes to an end, we’d like to share some of the successes, setbacks and enduring challenges of the past decade in global public health.”

 

3 – Your vitamin D tests and supplements are probably a waste of money – VOX (free)

Related: Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

“Screening for vitamin D has exploded — with no good evidence that it helps people.”

 

4 – Performance Improvement: Phenytoin Toxicity – JAMA (free)

Interesting case of medication error and prevention of subsequent adverse events (RT @JAMA_current see Tweet)

 

5 – Obstetrics and Gynaecology: Ten Things Physicians and Patients Should Question – Choosing Wisely (free) (RT @ChooseWiselyCA see Tweet)

“New Choosing Wisely recommendations list! @SOGCorg identifies 10 tests, treatments to question in obstetrics and gynecology

 

6 – ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee – Journal of the American College of Radiology (free, and legal, PDF via Unpawall)

Commentary: New ultrasound scoring system for thyroid nodules to reduce unnecessary biopsies – University of Alabama at Birmingham, via EurekAlert (free)

 

7 – Harnessing the Power of Data in Health – Stanford Medicine 2017 Health Trends Report (free PDF)

News release: Stanford Medicine launches health care trends report (free)

“Stanford Medicine launches report on health care trends” (RT @StanfordMed see Tweet)

 

8 – A medicine review is about stopping medicine as much as it is about prescribing – Royal Pharmaceutical Society of Great Britain (free) (RT @MaryanneDemasi see Tweet)

Original report: The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF)

Related: Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)

 

9 – Is aircraft noise exposure associated with cardiovascular disease and hypertension? Results from a cohort study in Athens, Greece – Occupational and Environmental Medicine (link to abstract – $ for full-text)

Commentaries: Noise May Raise Blood Pressure Risk – New York Times (10 articles per month are free) AND Long term exposure to aircraft noise linked to high blood pressure – The BMJ, via EurekAlert (free) AND Live Near an Airport? Nighttime Airplane Noise May Cause Hypertension – Medscape (free registration required)

Cohort study suggests a possible association.

 

10 – EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome (free)

Commentary: EULAR: Guidance for Managing Lupus Pregnancy – MedPage Today (free registration required)

 

Wed, June 21 – 10 Stories of The Day!

21Jun
2017

 

1 – Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer – Gastrointestinal Endoscopy (free)

Commentaries: Task Force presents new ranking of colorectal cancer screening tests – American Society of Gastrointestinal Endoscopy, via EurekAlert (free) AND Latest Colorectal Cancer Screening Guidelines – Latest Colorectal Cancer Screening Guidelines – GI and Hepatology News (free)

Related: Colorectal Cancer Screening – U.S. Preventive Services Task Force (free)

 

2 – Screening for Obesity in Children and Adolescents: US Preventive Services Task Force Recommendation Statement (free)

Editorial 1: Putting the US Preventive Services Task Force Recommendation for Childhood Obesity Screening in Context (free)

Editorial 2: Practical Considerations for the US Preventive Services Task Force Recommendations on Obesity in Children and Adolescents (free)

Author interview: USPSTF Recommendation: Screening for Obesity in Children and Adolescents (free audio)

The JAMA Network – for the media: Screening for Obesity in Children and Adolescents Recommended (free)

Commentary: USPSTF Recommends Screening For Obesity in Children and Adolescents – American College of Cardiology, Latest in Cardiology (free)

“The USPSTF recommends that clinicians screen for obesity in children and adolescents 6 years and older and offer or refer them to comprehensive, intensive behavioral interventions to promote improvements in weight status”

 

3 – The Evidence-Based Medicine Manifesto for Better Healthcare – Centre for Evidence-Based Medicine, University of Oxford (free)

 

4 – Review: Differentiating lower motor neuron syndromes – Journal of Neurology, Neurosurgery, and Psychiatry – Journal of Neurology, Neurosurgery, and Psychiatry (free)

 

5 – Antiplatelet Therapy in Patients With Coronary Stents Undergoing Elective Noncardiac Surgery: Continue, Stop, or Something in Between? – JAMA (free)

 

6 – Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers – JAMA (link to abstract – $ for full-text)

The JAMA Network – For the media: Study Estimates Age-Specific Overall Risk of Breast, Ovarian Cancer among Women with BRCA1/2 Genetic Mutations (free)

Commentary: Risk for Breast and Ovarian Cancer in BRCA1 and BRCA2 Mutation Carriers: Refining Our Estimates – Physician’s First Watch (free)

 

7 – Taxing sugary drinks would boost productivity, not just health – The Conversation (free)

Original article: The impact on productivity of a hypothetical tax on sugar-sweetened beverages – Health Policy (link to abstract – $ for full-text)

See more on the potential benefits of sugar taxes in our June 8th issue (see #4) and in our April 20th issue (see #1)

 

8 – Yoga, Physical Therapy, or Education for Chronic Low Back Pain: A Randomized Noninferiority Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Yoga Vs. Physical Therapy For Chronic Low Back Pain: Which Is More Effective? – Forbes (free) AND Yoga Noninferior to Physical Therapy for Low Back Pain – Physician’s First Watch (free) AND Yoga as Good for Low Back Pain as Physical Therapy – Medscape (free registration required)

 

9 – Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatment of Acute Urticaria: A Randomized Double-Blind Clinical Trial – Annals of Emergency Medicine (free)

Commentaries: No Benefit From Corticosteroids for Acute, Simple Urticaria – Medscape (free registration required) AND Got hives? Hold the steroids – American College of Emergency Physicians, via EurekAlert (free)

 

10 – Can Zika infection attack the brains of newborns? Scientists head to field for answers – STAT News (free)

Related: Is Zika Dangerous For Kids? It Probably Depends On The Age – NPR Goats and Soda (free)

 

Tue, June 20 – 10 Stories of The Day!

20Jun
2017

 

1 – Glucose targets for preventing diabetic kidney disease and its progression – Cochrane Library (link to summary – $ for full review)

Sources: EvidenceAlerts and @anupam1623

Intensive glycemic control had no effect on risks of kidney failure, death and major cardiovascular events. “The clinical impact of targeting an HbA1c < 7% or blood glucose < 6.6 mmol/L (120 mg/dL) is unclear and the potential harms of this treatment approach are largely unmeasured.”

 

2 – Evidence for Therapeutic Patient Education Interventions to Promote Cardiovascular Patient Self-Management: A Scientific Statement for Healthcare Professionals From the American Heart Association (free)

News Release: Healthcare providers should individualize patient education (free)

AHA statement: Doctors’ orders should include tailored health education for patients (free)

Commentary: Sharpening the Focus on Therapeutic Patient Education and Self-management (free)

Top Ten Things to Know: Evidence for Therapeutic Patient Education Interventions to Promote Cardiovascular Patient Self-Management (free PDF)

 

3 – Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Antibiotic Stewardship Programs Linked to Lower Rates of Drug-Resistant Infections – Physician’s First Watch (free) AND Review ties stewardship to sharp drop in resistant bacteria – CIDRAP (free)

 

4 – Reducing Cancer Burden in the Population: An Overview of Epidemiologic Evidence to Support Policies, Systems, and Environmental Changes – Epidemiologic Reviews (free)

 

5 – Treating patients with opioid disorders is not just about treating addiction. Here’s why – STAT News (free)

Original analysis: What data from 205 million private health insurance claims reveals about America’s opioid crisis – Amino (free)

 

6 – Alterations in Cardiac Deformation, Timing of Contraction and Relaxation, and Early Myocardial Fibrosis Accompany the Apparent Recovery of Acute Stress-Induced (Takotsubo) Cardiomyopathy: An End to the Concept of Transience – Journal of the American Society of Echocardiography (link to abstract – $ for full-text)

Commentaries: Broken heart syndrome may have lasting damage, say researchers – BBC Health News (free) AND Broken heart syndrome may cause permanent damage – News Medical (free) AND ‘Octopus pot’ syndrome: why a broken heart can be as bad as cardiac arrest – The Guardian (free)

 

7 – Changes in Hospital Quality Associated with Hospital Value-Based Purchasing – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Value-Based Purchasing Program Has Little Effect – Medscape (free registration required) AND Is There Value in Hospital Value-Based Purchasing? – NEJM Catalyst (free)

How VBP works: Hospital Value-Based Purchasing – U.S. Centers for Medicare & Medicaid Services (free)

 

8 – Richard Lehman’s weekly review of medical journals, 19 June 2017 – The BMJ Blogs (free)

 

9 – The Science Behind How Nature Affects Your Health – Forbes (free)

“100% agree: Social determinants of health have a far greater impact on our health than healthcare delivery systems” (RT @SueDHellmann see Tweet)

 

10 – Inspired by War Zones, Balloon Device May Save Civilians From Fatal Blood Loss – The New York Times (10 articles per month are free)

 

Mon, June 19 – 10 Stories of The Day!

19Jun
2017

 

1 – Comparison of sputum collection methods for tuberculosis diagnosis: a systematic review and pairwise and network meta-analysis – The Lancet Global Health (free)

Invited commentary: Remembering the basics: interventions to improve sputum collection for tuberculosis diagnosis (free)

Pooled sputum collection (sputum that was pooled from each spontaneous expectoration into the same sputum container over a period of several hours) increased the diagnostic performance of smear microscopy 1.6 times and the delivery of standardized instruction emphasizing the difference between sputum and saliva (verbally or visually) increased the odds of a positive microscopy result 1.4 times. “The effect of these simple, inexpensive strategies on diagnostic performance was similar to that of the relatively expensive GeneXpert MTB/RIF test, which, in the largest published studies, increased the odds of diagnosing tuberculosis by 1.3–1.5 times”

 

2 – Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association (free PDF)

Invited Commentary: Trimming the Fat on Diet Recommendations for a Healthy Heart: Emphasis on Eating Patterns over Dietary Restrictions (free)

Top Ten Things to Know: Dietary Fats and Cardiovascular Disease: A Presidential Advisory from the American Heart Association (free PDF)

AHA News: Advisory: Replacing saturated fat with healthier fat could lower cardiovascular risks (free)

News release: Replacing saturated fat with healthier fat may lower cholesterol as well as drugs in context of a healthy diet (free)

AHA no longer recommends decreasing total fat, but to replace saturated fats with polyunsaturated or monounsaturated fats. “Replacing saturated fat with healthier fat in the diet lowers cardiovascular disease risk as much as cholesterol-lowering statin drugs”

 

3 – Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study – The BMJ (free)

Commentary: New web calculator to more accurately predict bowel cancer survival – University of Nottingham, via EurekAlert (free)

See also: QCancer-2017(colorectal, survival) risk calculator (free risk calculator based on the data)

 

4 – Racial Differences in the Relationship of Glucose Concentrations and Hemoglobin A1c Levels – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Glycation of Hemoglobin Differs by Race – Physician’s Briefing (free) AND Hemoglobin A1c Overestimates Average Glucose in Blacks – Medscape (free registration required) AND Why a key diabetes test may work differently depending on your race – CNN (free)

In this study with 104 black patients and 104 white patients with type 1 diabetes, HbA1c values in black persons were 0.4 percentage points higher than those in white persons for a given mean glucose concentration.

 

5 – Free online course. Starts today! Improving the Health of Women, Children and Adolescents: from Evidence to Action – London School of Hygiene & Tropical Medicine, via FutureLearn (free)

 

6 – 2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty (free)

Press release: New Guideline Aims to Reduce Infections in Total Hip & Knee Replacement Patients (free)

Commentaries: New medication guidelines for rheumatic disease patients having joint replacement – Hospital for Special Surgery, via EurekAlert (free) AND New Guidelines Issued on Antirheumatic Drugs for Patients Undergoing Knee or Hip Replacement – Physician’s First Watch (free)

 

 

7 – What If (Almost) Every Gene Affects (Almost) Everything? – The Atlantic (free) (RT @AllenFrancesMD see Tweet)

 

8 – Evolocumab for Treatment of High Cholesterol: Clinical Effectiveness (free PDF) (RT @AnilMakam see Tweet 1, Tweet 2, Tweet 3 and Tweet 4)

News release: Institute for Clinical and Economic Review’s “New Evidence Update” on PCKS9 Inhibitors Highlights Lack of Mortality Benefit With Evolocumab (free)

Lack of mortality benefit in a recent large trial is highlighted in this updated review. Se more on the FOURIER trial and commentaries in our March 20th issue, see #2.

 

9 – Why are doctors killing themselves? – by Anne Malatt, via MJA Insight (free)

Related: Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT News (free)

 

10 – EULAR/EFORT recommendations for management of patients older than 50 years with a fragility fracture and prevention of subsequent fractures (free)

 

Fri, June 16 – 10 Stories of The Day!

16Jun
2017

 

1 – World Elder Abuse Awareness Day (June 15, 2017)

WHO News release: Abuse of older people on the rise – 1 in 6 affected – World Health Organization (free)

See also:  Elder abuse fact sheet (free) AND WHO’s work on elder abuse (free) AND World report on ageing and health (free)

Related: Elder abuse prevalence in community settings: a systematic review and meta-analysis – The Lancet Global Health (free) AND Protecting the global longevity dividend – The Lancet Global Health (free)

 

2 – OpenWHO – The World Health Organization launched a series of video courses on epidemics, pandemics & health emergencies, open to the public (free courses and videos) (RT @WHO see Tweet)

 

3 – A randomized trial of telemedicine efficacy and safety for nonacute headaches – Neurology (free) (RT @EricTopol see Tweet)

Commentary: For Headache, Telemedicine May Be as Effective as in-Person – American Academy of Neurology, via NewsWise (free)

 

4 – New Choosing Wisely List: American Society of Health-System Pharmacists – Five Things Physicians and Patients Should Question (free)

See more on the Choosing Wisely initiative in our April 5 issue, see #6.

“Great choosing wisely list from @ASHPOfficial. Great doctoring tips for physicians & trainees” (RT @AnilMakam see Tweet)

 

5 – Doctors are prone to burn-out and depression. We need to take care – World Economic Forum (free)

 

6 – Pharmacological treatments and risk of readmission to hospital for unipolar depression in Finland: a nationwide cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary: Lithium Markedly Cuts Hospital Readmission in Depression – Medscape (free registration required)

 

7 – Review: Pathophysiology of Takotsubo Syndrome – Circulation (free)

 

8 – Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons – The BMJ (free)

Commentaries: Risks of major birth defects greater if mother is overweight – OnMedica (free) AND Obese women more likely to have babies with serious birth defects, says study – The Guardian (free)

 

9 – Machine Learning Versus Standard Techniques for Updating Searches for Systematic Reviews: A Diagnostic Accuracy Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Artificial intelligence may help doctors keep up with new research – Reuters (free)

“Machine-learning fed by citations of a systematic saved a ton of time for updating it, didn’t miss important studies” (RT @hildabast see Tweet)

 

10 – Opinion: Too much medical care: bad for you, bad for health care systems – STAT News (free)

 

Thu, June 15 – 10 Stories of The Day!

15Jun
2017

 

1 – World Blood Donor Day (June 14, 2017) – World Health Organization (free)

See also: 10 facts on blood transfusion (free) AND Giving blood in a time of crisis (free) AND WHO’s work on blood transfusion safety (free)

 

2 -Time to Delivery of an Automated External Defibrillator Using a Drone for Simulated Out-of-Hospital Cardiac Arrests vs Emergency Medical Services – JAMA (link to abstract – $ for full-text)

The JAMA Network – For the Media: Can Use of a Drone Improve Response Times for Out-Of-Hospital Cardiac Arrests Compared to an Ambulance? (free)

Commentaries: Drones Can Get Defibrillators to Bystanders Faster Than EMS Can – Physician’s First Watch (free) AND Defibrillator Drones Can Reach You Four Times Faster Than EMS – ECN (free)

In 18 simulated cases in Sweden, the drones could get automatic external defibrillators to the scene an average of 16 minutes faster than emergency medical services.

 

3 – 6 Ways Drones Could Change Health Care – Scientific American (free)

 

4 – Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentary: NOAC Doses: Just Stick to the Label – MedPage Today (free registration required)

“Among the 1,473 patients with a renal indication for dose reduction, 43.0% were potentially overdosed, which was associated with a higher risk of major bleeding”

 

5 – Hospitals Are Dramatically Overpaying for Their Technology – Harvard Business Review (a few articles per month are free)

“For years, hospitals have invested in sophisticated devices and IT systems that, on their own, can be awe-inspiring. Yet these technologies rarely share data, let alone leverage it to support better clinical care”.

 

6 – Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

The JAMA Network – For the Media: Treating Nutritional Iron-Deficiency Anemia in Children (free)

Commentaries: Ferrous Sulfate Drops Tied to Higher Hemoglobin Increases in Kids with Anemia – Physician’s First Watch (free) AND Traditional treatment is better for iron-deficiency anaemia in children – OnMedica (free) AND Ferrous Sulfate Effective for Iron-Deficiency Anemia in Kids – Medscape (free registration required)

Researchers expected that Iron Polysaccharide Complex would restore hemoglobin more effectively, because it is designed to be tolerated better, but the proportion of infants and children with a complete resolution of iron-deficiency anemia was higher in the ferrous sulfate group (29 percent vs 6 percent).

 

7 – Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events: a population-based cohort study – The Lancet (free)

Invited commentary: Preventing major gastrointestinal bleeding in elderly patients (free)

Commentaries: Aspirin Bleeding Risk in Over 75s Higher Than Thought – Medscape (free registration required) AND Aspirin linked to higher risk of serious bleeding in the elderly – Reuters Health News (free)

In this cohort, the risk of major bleeding increased sharply in patients above 75 years.

 

8 – Reframing non-communicable diseases as socially transmitted conditions – The Lancet Global Health (free)

“Socially transmitted conditions”: a new name for non-communicable diseases (RT @LancetGH see Tweet)

 

9 – Essential medicines require essential diagnostics – The Huffington Post Canada Blogs (free)

See more about the new WHO list of essential medicines in our June 7th issue, see #1.

“To use essential medicines, have to know what you’re treating says @paimadhu so need essential diagnostics list too” (RT @markcha see Tweet)

 

10 – Real-World Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of 29 823 Patients With Schizophrenia – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Oral clozapine, long-acting injectables tied to lower relapse risk in schizophrenia – Clinical Psychiatry News (free registration required) AND Long-Acting Antipsychotics Tied to Superior Outcomes – Medscape (free registration required)

“The risk of rehospitalization is about 20% to 30% lower during long-acting injectable treatments compared with equivalent oral formulations”

 

Wed, June 14 – 10 Medical Stories of The Day!

14Jun
2017

 

1 – Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes – New England Journal of Medicine (free)

Commentary: CANVAS: Canagliflozin Reduces CV Events, but at Cost of Amputations – Medscape (free registration required)

Patients treated with canagliflozin had a lower risk of cardiovascular events than those who received placebo but a greater risk of amputation and fractures. The benefits and harms were likely small. See interesting commentaries on the trade-offs by @AnilMakam, see Tweet 1; Tweet 2; Tweet 3; Tweet 4; Tweet 5; Tweet 6; Tweet 7; Tweet 8; and Tweet 9.

 

2 – The End of Human Doctors – The Bleeding Edge of Medical AI Research (Part 1) – By Luke Oakden-Rayner (RT @pash22 see Tweet)

Original article: Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs – JAMA (free)

See more on the impact of artificial intelligence in healthcare in our April 28th issue, see #1, and in our April 10th issue, see #8

 

3 – The End of Human Doctors – The Bleeding Edge of Medical AI Research (Part 2) – By Luke Oakden-Rayner (RT @pash22 see Tweet)

Original article: Dermatologist-level classification of skin cancer with deep neural networks – Nature (link to abstract – $ for full-text)

See more on the impact of artificial intelligence in healthcare in our April 28th issue, see #1, and in our April 10th issue, see #8

 

4 – Association of Adverse Events With Antibiotic Use in Hospitalized Patients – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Antibiotic-Associated Adverse Events Common – Medscape (free registration required)

“20% of hospitalized patients receiving antibiotics had adverse drug event. Of those, 20% of regimens inappropriate” (RT @PeterPronovost see Tweet)

 

5 – Medical News & Perspectives: More Treatments on Deck for Alcohol Use Disorder – JAMA (free)

 

6 – Association Between Persistent Pain and Memory Decline and Dementia in a Longitudinal Cohort of Elders – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Persistent Pain May Increase Dementia Risk – The New York Times (10 articles per month are free)

Cohort of community-dwelling older adults suggests there might be a link.

 

7 – Snakebite finally makes a WHO list of top global health priorities – STAT News (free)

 

8 – How to fall to your death and live to tell the tale – Mosaic Science (free)

“Falls—such as slipping in the shower or tripping down stairs—kill over 420,000 people worldwide each year” (RT @ghn_news see Tweet)

 

9 – A Test in Context: Fractional Flow Reserve: Accuracy, Prognostic Implications, and Limitations – Journal of The American College of Cardiology (link to abstract – $ for full-text)

10 key points to remember: FFR: Accuracy, Prognostic Implications, and Limitations – American College of Cardiology, Latest in Cardiology (free)

 

10 – Combination inhaler treatment in emergency departments may reduce admissions for asthma attacks – NIHR Signal (free)

Original article: Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma – Cochrane Library (link to abstract – $ for full-text)

 

Tue, June 13 – 10 Medical Stories of The Day!

13Jun
2017

 

1 – Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free)

Editorial: Global Health Effects of Overweight and Obesity (free)

Commentaries: New study finds more than 2 billion people overweight or obese – Institute for Health Metrics and Evaluation (free) AND More Than 10 Percent of World’s Population Is Obese, Study Finds – The New York Times (free) AND Being overweight – not just obese – kills millions a year, say experts – The Guardian (free)

“High BMI accounted for 4.0 million deaths globally, nearly 40% of which occurred in persons who were not obese”

 

2 – Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign–Based Electronic Alert and Bedside Clinician Identification – Annals of Emergency Medicine (free)

Editorial: Between the Devil and the Deep Blue Sea: Use of Real-Time Tools to Identify Children With Severe Sepsis in the Pediatric Emergency Department (free)

Commentary: New pediatric protocol reduces missed sepsis diagnoses by 76 percent – American College of Emergency Physicians, via EurekAlert (free)

 

3 – Strategies for Preventing HIV Infection Among HIV-Uninfected Women Attempting Conception with HIV-Infected Men – CDC/MMWR (free)

Commentaries: CDC Outlines Options for HIV-Discordant Couples Who Want to Conceive – Physician’s First Watch (free) AND CDC Reversal: Sperm From HIV-Infected Men Okay for Insemination – Medscape (free registration required)

 

4 – It’s time to get serious about the safety of medical devices – STAT News (free)

 

5 – The 2017 Focused Update of the Guidelines of the Taiwan Society of Cardiology (TSOC) and the Taiwan Hypertension Society (THS) for the Management of Hypertension (free)

 

6 – Kidney Cancer, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology (free)

 

7 – Guidelines for the recognition and management of mixed depression – CNS Spectrums (free)

Commentary: First-Ever Guideline for Mixed Depression Released – Medscape (free registration required)

 

8 – Richard Lehman’s weekly review of medical journals, 12 June 2017 – The BMJ Blogs (free)

 

9 – Conflicts of interest in health care journalism. Who’s watching the watchdogs? We are. Part 1 of 3 – HealthNewsReview (free)

 

10 – Drugs may help people pass larger kidney stones – NIHR Signal (free)

Original article: Alpha blockers for treatment of ureteric stones: systematic review and meta-analysis – The BMJ (free)

 

Mon, June 12 – 10 Medical Stories of The Day!

12Jun
2017

 

1 – New Series from The Lancet: Health in Humanitarian Crises (free registration required)

Related: How to Fix the Broken Humanitarian System: A Q&A with Paul Spiegel – Global Health NOW (free)

“Evidence is important to guide more effective & efficient health responses in humanitarian contexts” (RT @TheLancet see Tweet)

 

2 – Glucose Self-monitoring in Non–Insulin-Treated Patients With Type 2 Diabetes in Primary Care Settings: A Randomized Trial – JAMA Internal Medicine (free)

Editorial: The Need to Test Strategies Based on Common Sense (free)

The JAMA Network – For the Media: Home Monitoring of Blood Sugar Did Not Improve Glycemic Control After 1 Year (free)

Commentary: Is the finger-stick blood test necessary for type 2 diabetes treatment? – University of North Carolina Health Care, via EurekAlert (free)

Related: Self-Monitoring of Blood Glucose – Canadian Agency for Drugs and Technologies in Health (free)

“Another RCT showing no benefit for Glucose Self-monitoring in Non–Insulin-Treated Patients with Type 2 Diabetes” (RT @PaulGlasziou see Tweet)

 

3 – Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

 

4 – Palliative care: A pathway to value-based care for nursing homes – Diane E. Meier, M.D via McKnight (free)

 

5 – ‘How long have I got?’: Why many cancer patients don’t have answers – USA Today (free)

Related: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

See more on Standardized Criteria for Palliative Care Consultation in our April 24 issue, see #8

“ASCO now recommends that everyone with advanced cancer receive palliative care within eight weeks of diagnosis.” (RT @cancerassassin1 see Tweet)

 

6 – Diagnosis and management of dementia with Lewy bodies – Neurology (free)

Commentary: New International Guidelines Issued on Dementia with Lewy Bodies – Mayo Clinic, via NewsWise (free)

 

7 – Timing of food introduction and development of food sensitization in a prospective birth cohort – Pediatric Allergy and Immunology (link to abstract – $ for full-text)

Commentary: Delayed food introduction may increase likelihood of allergy in later childhood – McMaster University, via News Medical (free)

 

8 – Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study – Circulation (free PDF)

Commentaries: Risk of HF and Death in Patients on SGLT-2 Inhibitors – American College of Cardiology, Latest in Cardiology (free) AND SGLT2 inhibitors may have class effect for reduction of cardiac risk – ACP Diabetes Monthly (free)

Observational data suggests these class of drugs may be associated with lower risk of heart failure and deaths compared to other drugs.

 

9- Canagliflozin will receive new boxed warning about amputation risks – ACP Internist (free)

FDA Drug Safety Communication: FDA confirms increased risk of leg and foot amputations with the diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) (free)

 

10 – Working with influenza-like illness: Presenteeism among US health care personnel during the 2014-2015 influenza season – American Journal of Infection Control (link to abstract – $ for full-text)

Commentaries: Working while sick – ACP Internist (free) AND Health worker survey reveals many work during flu illness – CIDRAP (free)

Over 40% of surveyed health care personnel worked with self-reported influenza-like illness. “To reduce levels of health-worker–associated flu transmission, the researchers said that misconceptions about working while sick and sick leave policies both need to be addressed” (from CIDRAP)

 

Fri, June 9 – 10 Medical Stories of The Day!

9Jun
2017

 

1 – Head injury: assessment and early management – NICE Guideline (free)

 

2 – Are Small Breast Cancers Good because They Are Small or Small because They Are Good? – New England Journal of Medicine (no abstract available – $ for full-text)

Commentaries: Some Small Tumors In Breasts May Not Be So Bad After All – NPR Health News (free) AND Mammograms: Are we overdiagnosing small tumors? – Yale University, via MedicalXpress (free) AND With Breast Cancer, the Best Treatment May Be No Treatment – Wired (free)

See a related article and commentaries on Mammography and Overdiagnosis in our October 14th, 2016 issue, see #1 and #2.

 

3 – Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma – New England Journal of Medicine (link to abstract – $ for full-text)

Quick take video summary: Dissection or Observation for Sentinel-Node Metastasis (free)

Commentaries: Watch-and-Wait OK in Sentinel Node Positive Melanoma – MedPage Today (free registration required) AND Common Surgical Treatment for Melanoma Does Not Improve Patients’ Overall Survival, Study Shows – Cedars-Sinai Medical Center, via NewsWise (free)

 

4 – 2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis (free)

Commentary: ACR Releases Guideline on prevention & treatment of glucocorticoid-induced osteoporosis – American College of Rheumatology, via EurekAlert (free)

 

5 – Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration – Anesthesiology, via Medscape (free registration required)

 

6 – Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor – New England Journal of Medicine (free)

Commentaries: Study Warns of Diabetic Ketoacidosis With SGLT2 Inhibitors in T2D – MedPage Today (free registration required) AND SGLT2 Inhibitors Double the Risk for Diabetic Ketoacidosis – Medscape (free registration required) AND New class of type 2 diabetes drug associated with rare, life-threatening outcome – Brigham and Women’s Hospital, Via EurekAlert (free)

Related: SGLT2 inhibitors and diabetic ketoacidosis: data from the FDA Adverse Event Reporting System – Diabetologia (link to abstract – $ for full-text)

 

7 – Precision Oncology: Who, How, What, When, and When Not? – ASCO Educational Book (free) (RT @pash22)

See also: 2017 ASCO Educational Book – full volume (free)

 

8 – Hope and hype around cancer immunotherapy – CNN (free)

 

9 – Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy – Cochrane Library (link to abstract – $ for full-text)

“Cervical cerclage reduces the risk of preterm birth in women at high-risk of preterm birth and probably reduces risk of perinatal deaths”

 

10 – Income and Cancer Overdiagnosis: When Too Much Care Is Harmful – New England Journal of Medicine (no abstract available – $ for full-text)

Commentary: Are wealthier people more likely to receive a diagnosis of cancer? – Dartmouth Institute for Health Policy and Clinical Practice, via EurekAlert (free)

 

Thu, June 8 – 10 Medical Stories of The Day!

8Jun
2017

 

1 – Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study – The BMJ (free)

Editorial: Alcohol consumption and brain health (free)

Commentaries: Even moderate drinking linked to a decline in brain health, finds study – Oxford’s Department of Psychiatry (free) AND Moderate drinking may alter brain, study says – CNN (free) AND Even moderate drinking may speed brain decline – STAT News (free) AND Even moderate drinking linked to changes in brain structure, study finds – Reuters (free)

 

2 – Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies – The BMJ (free)

Observational studies suggest that high serum uric acid levels are associated with multiple health outcomes, including cardiovascular and metabolic diseases. This review findings suggest there is a clear association only for gout and nephrolithiasis.

 

3 – The opioid crisis changed how doctors think about pain – VOX (free)

“One of the expectations our patients have is that pain can be completely eliminated. We as a medical community are coming to an understanding that this is not realistic.” (RT @KariTikkinen and @voxdotcom and see Tweet)

 

4 – Reducing US cardiovascular disease burden and disparities through national and targeted dietary policies: A modelling study – PLOS Medicine (free)

Commentaries: Change in USA food policies could prevent 230,000 heart disease deaths by 2030 – Imperial College of London (free) AND U.S. nutrition policies may cut heart disease and save lives – Reuters Health News (free)

Related: Taxes and Subsidies for Improving Diet and Population Health in Australia: A Cost-Effectiveness Modelling Study – PLOS Medicine (free) AND The US had no soda taxes in 2013. Now nearly 9 million Americans live with them – VOX (free)

“Increased discounts on fruit and vegetables, and higher taxes on sugary drinks, could prevent heart disease deaths, says a new study” (from Imperial College of London commentary)

 

5 – Perspective: Cyberattack on Britain’s National Health Service: A Wake-up Call for Modern Medicine – New England Journal of Medicine (free)

Related: 11 Things the Health Care Sector Must Do to Improve Cybersecurity – Harvard Business Review (free) AND Eric D Perakslis: Cyber security modeled as infection prevention and control in the healthcare delivery setting – The BMJ Opinion (free) AND Healthcare Seen Highly Vulnerable to Cyberattack – MedPage Today (free registration required)

 

6 – Current and future perspectives on the management of polypharmacy – BMC Family Practice (free) (RT @Azeem_Majeed see Tweet)

 

7 – Handshake-free zone in a neonatal intensive care unit: Initial feasibility study – American Journal of Infectious Control (link to abstract – $ for full-text)

Commentaries: Hospitals Could One Day Be Handshake-Free Zones To Prevent The Spread Of Disease – WBGH News (free) AND Handshake-Free Zone: Stopping the Spread of Germs in the Hospital – Medscape (free registration required) AND Handshake-Free Zones Target Spread Of Germs In The Hospital – NPR Health News (free)

 

8 – Association of Gestational Weight Gain With Maternal and Infant Outcomes: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: RCOG statement on gestational weight gain or loss and adverse outcomes – Royal College of Obstetricians and Gynaecologists (free) AND Weight gain greater, less than recommended during pregnancy linked with increased risk of adverse outcomes – The JAMA Network Journals, via EurekAlert (free) AND Pregnancy Weight Gain Status Tied to Adverse Outcomes – MedPage Today (free registration required) AND Gaining Too Much, Too Little Weight in Pregnancy Tied to Adverse Outcomes for Mother, Baby – Physician’s First Watch (free) AND Global study finds 75% of pregnant women don’t have healthy weight gain – The Guardian (free)

 

9 – Pelvic floor exercises may reduce need for further treatments for pelvic organ prolapse – NIHR Signal (free)

Original article: Pelvic floor muscle training for secondary prevention of pelvic organ prolapse (PREVPROL): a multicentre randomised controlled trial – The Lancet (link to abstract – $ for full-text)

 

10 – Eggs in Early Complementary Feeding and Child Growth: A Randomized Controlled Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Eggs Significantly Increase Growth in Young Children – Washington University in St. Louis, via NewsWise (free) AND An egg a day appears to help young children grow taller – BBC Health News (free)

“Surpassing previous research, study finds eggs are more viable nutrition, better intervention for children in developing countries” (from NewsWise)

 

Wed, June 7 – 10 Medical Stories of The Day!

7Jun
2017

 

1 – News release: WHO updates Essential Medicines List with new advice on use of antibiotics, and adds medicines for hepatitis C, HIV, tuberculosis and cancer (free)

Report 1: The 2017 Expert Committee on the Selection and Use of Essential Medicines (free PDF)

Report 2: WHO Model List of Essential Medicines (free PDF)

Report 3: WHO Model List of Essential Medicines for Children (free PDF)

Commentaries: WHO creates controversial ‘reserve’ list of antibiotics for superbug threats – The Washington Post (free) AND Health officials set to release a list of drugs everyone on Earth should be able to access – STAT News (free) AND WHO’s New Essential Medicines List Includes a 40-Year First – Medscape (free registration required)

WHO Essential Medicines List is used by many countries to guide decisions regarding which medications should be available for their population.

 

2 – Pharmacologic Management of Newly Detected Atrial Fibrillation: Updated clinical practice guideline:  – American Academy of Family Physicians (free PDF)

Key Recommendations: Pharmacologic Management of Newly Detected Atrial Fibrillation (free)

 

3 – #ASCO2017 (Unpublished results) – Risk-Based Approach to Chemotherapy Duration Recommended for Stage III Colon Cancer – ASCO Daily News (free) AND ASCO2017:The IDEA Collaboration: Global Study Sets New Risk-Based Standard to Personalize Chemotherapy for Colon Cancer After Surgery – ASCO Post (free)

Commentaries: Chemo Cut in Half Following Surgery Without Increased Recurrence Risk in Patients With Low-Risk Colon Cancer – Targeted Oncology (free) Less Is More: Patients With Colon Cancer Get a Chemo Break – Medscape (free registration required) Cutting Chemo Time in Low-Risk Colon Ca an Option – MedPage Today (free registration required)

 

4 – #ASCO2017 (Unpublished results) – Pregnancy After Breast Cancer Does Not Increase Chance of Recurrence – ASCO News Releases (free)

Commentaries: Yes, a Pregnancy After Breast Cancer Is Safe – Medscape (free registration required) AND Pregnancy after breast cancer doesn’t raise recurrence risk – Reuters Health News (free) AND Pregnancy After Breast Cancer Does Not Increase Recurrence Risk – Oncology Times (free)

 

5 – Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis: Systematic Review and Meta-analysis of Controlled Trials – Annals of Surgery (link to abstract – $ for full-text)

Commentary: Antibiotics Versus Surgery: Equally Effective in Treating Appendicitis? – Medscape (free registration required)

This meta-analysis and the author’s conclusions do not favor antibiotics alone for the treatment of uncomplicated appendicitis, contradiction the results of other recent meta-analysis, as well as a recent guideline on the subject, suggesting antibiotics might be an option in selected cases.

 

6 – BSACI guideline for the diagnosis and management of peanut and tree nut allergy – British Society for Allergy and Clinical Immunology (free)

Editorial: Nut allergy guideline (free)

Commentary: First ever single guidance published for investigating and managing nut allergy – EurekAlert (free)

See also related guidelines (U.S.) and commentaries recommending early introduction of peanuts to prevent allergies in our January 6 issue, see #1 and #2.

 

7 – Data fabrication and other reasons for non-random sampling in 5087 randomised, controlled trials in anaesthetic and general medical journals – Anaesthesia (free)

Commentaries: Dozens of recent clinical trials may contain wrong or falsified data, claims study – The Guardian (free) AND Two in 100 clinical trials in eight major journals likely contain inaccurate data: Study – Retraction Watch (free)

 

8 – Inflammatory bowel disease: Five things physicians and patients should question – Choosing Wisely Canada (free)

 

9 – Association Between Cirrhosis and Stroke in a Nationally Representative Cohort – JAMA Neurology (free)

Commentary: Cirrhosis Tied to Stroke Risk- Physician’s First Watch (free)

Patients with cirrhosis seem to have a higher risk of stroke, particularly hemorrhagic stroke.

 

10 – Current Tobacco Smoking and Desire to Quit Smoking Among Students Aged 13–15 Years — Global Youth Tobacco Survey, 61 Countries, 2012–2015 – MMWR: Centers for Disease Control and Prevention (free)

Commentaries: What’s The Rate Of Smoking In The 13- To 15-Year-Old Crowd? – NPR Goats and Soda (free)

 

Tue, June 6 – 10 Medical Stories of The Day!

6Jun
2017

 

1 – The impact of the environment on children’s health – New WHO Reports

News release: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free)

Report 1: Don’t pollute my future! The impact of the environment on children’s health – World Health Organization (free)

Report 2: Inheriting a sustainable world: Atlas on children’s health and the environment – World Health Organization (free)

Related links: WHO’s work on environmental health (free) AND 10 facts on children’s environmental health (free)

 

2 – #ASCO2017 – CT-P6 compared with reference trastuzumab for HER2-positive breast cancer: a randomised, double-blind, active-controlled, phase 3 equivalence trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Biosimilar May Be As Effective as Trastuzumab for Early Breast Cancer – Physician’s First Watch (free)

 

3 – #ASCO2017 – Small studies get big headlines at ASCO 2017 – HealthNewsReview (free)

“Claim – Biggest breakthrough in a decade”. “Reality – The trial included only 15 women; no survival outcomes measured” (RT @HealthNewsRevu see Tweet)

 

4 – Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Simplified Diagnosis of Acute PE: The YEARS Study – American College of Cardiology, Latest in Cardiology (free) AND A Simple, Safe Approach to Decrease Use of CT for Pulmonary Embolism – Journal Watch (free)

 

5 – Growth and Rupture Risk of Small Unruptured Intracranial Aneurysms: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Growth, rupture risk appear low for small intracranial aneurysms, review indicates – ACP Internist Weekly (free) AND How Frequently Do Small Brain Aneurysms Rupture? – MedPage Today (free registration required)

“The annualized rupture rate was 0% for aneurysms 3 mm or smaller, below 0.5% for aneurysms 5 mm or smaller, and below 1% for aneurysms 7 mm or smaller”

 

6 – Health officials set to release a list of drugs everyone on Earth should be able to access – STAT News (free)

“The World Health Organization is making a list of drugs that everyone on Earth should have access to” (RT @statnews see Tweet)

 

7 – Small Steps Can Save Millions of Lives – Bloomberg (free) (RT @ghn_news see Tweet)

“More people now die from noncommunicable diseases than from causes like malaria and polio. Policy makers need to catch up”.

 

8 – Data Sharing Statements for Clinical Trials — A Requirement of the International Committee of Medical Journal Editors (free)

 

9 – Assessing the Efficacy of First-Aid Measures in Physalia sp. Envenomation, Using Solution- and Blood Agarose-Based Models – Toxins (free)

Commentary: What is the best antidote for a jellyfish sting? (Clue: it’s not urine) – The Guardian (free)

Vinegar seems to be the best treatment.

 

10 – Prenatal antidepressant use and risk of attention-deficit/hyperactivity disorder in offspring: population based cohort study – The BMJ (free)

Editoral: The safety of antidepressants in pregnancy (free)

Commentary: Kids’ ADHD Risk May Be Linked to Mother’s Underlying Mental Health, Not Prenatal Antidepressant Use – Physician’s First Watch (free)

 

Mon, June 5 – 10 Medical Stories of The Day!

5Jun
2017

 

1 – #ASCO2017 – Overall Survival Results of a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment – JAMA (free)

Commentaries: Quickly reporting cancer complications may boost survival – STAT News (free) AND If This Were a Drug, the Price Would Be $100,000 – Medscape (free registration required) AND How a simple tech tool can help cancer patients live longer – The Washington Post (free)

“For surveillance of cancer, digital tracking of patient-generated data improves survival”. “The cost of digital tracking is very low and > 5 months median survival improvement is more than cancer drugs that cost > $100,000” (RT @EricTopol see Tweets and Answers)

 

2 – #ASCO2017 – Abiraterone for Prostate Cancer

Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer – New England Journal of Medicine (free) AND Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy – New England Journal of Medicine (free)

ASCO News Releases: Abiraterone Delays Metastatic Prostate Cancer Growth by 18 Months, Extends Survival (free) Abiraterone Slows Advanced Prostate Cancer, Helps Patients Live Longer (free)

 

3 – Perspectives: Changing the narratives for patient safety – World Health Organization (free)

“No simple solutions to patient safety: why we have to change the narratives” (RT @MaryDixonWoods See Tweet)

 

4 – Engaging Patients in Patient Safety – a Canadian Guide (free) (RT @pash22)

News release: How to Effectively Engage Patients in Patient Safety: New Guide available (free)

 

5 – ACP Decries Withdrawal from Climate Agreement – American College of Physicians (free)

See also: How scientists reacted to the US leaving the Paris climate agreement – Nature News (free) Leaving the Paris Climate Accord Could Lead to a Public Health Disaster – Scientific American (free)

Related guideline: Climate Change and Health: A Position Paper of the American College of Physicians (free)

See more on Climate Change and Health in our April 21 issue, see #6, #7, #8 and #9.

 

6 – Introducing a One-Page Adult Preventive Health Care Schedule: USPSTF Recommendations at a Glance – American Family Physician (free PDF)

“The popular one-page preventive health care schedule is now available with the latest USPSTF recs from 2017” (RT @AFPJournal see Tweet)

 

7 – Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015 – The Lancet Infectious Diseases (free)

Invited commentary: Diarrhoeal disease trends in the GBD 2015 study: optimism tempered by skepticism (free)

Other commentaries: Despite substantial global reduction in diarrhea deaths, half a million children still die from diseases each year – Institute for Health Metrics and Evaluation (IHME) (free) AND Global diarrhoea deaths down by a third – BBC News (free)

“Deaths due to diarrhoea in children under 5 down 34% 2005-15, but still 4th leading cause of death” (RT @TheLancetInfDis see Tweet)

Global diarrhoea deaths in children down by a third, but still fourth biggest killer in under fives, >500,000 a year” (RT @anetrid see Tweet)

 

8 – Spondyloarthritis in over 16s: diagnosis and management – NICE Updated Guideline (free)

See also: 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis (free)

 

9 – Italy has introduced mandatory vaccinations – other countries should follow its lead – The Conversation (free)

See more on mandatory vaccination in our May 29 issue, see #6

 

10 – Carotid Artery Stenting Versus Endarterectomy for Stroke Prevention: A Meta-Analysis of Clinical Trials – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: CAS vs. CEA for Stroke Prevention – American College of Cardiology, Latest in Cardiology (free)

“CAS and CEA were associated with similar rates of a composite of periprocedural death, stroke, MI, or nonperiprocedural ipsilateral stroke. The risk of long-term overall stroke was significantly higher with CAS, and was mostly attributed to periprocedural minor stroke”.

 

Fri, June 2 – 10 Medical Stories of The Day!

2Jun
2017

 

1 – EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis (free)

Commentary: EASL releases updated guidelines for managing hepatitis B virus infection – Clinical Advisor (free registration required)

 

2 – Trial of Minocycline in a Clinically Isolated Syndrome of Multiple Sclerosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Minocycline to Delay the Onset of MS

Commentaries: Acne antibiotic delays development of multiple sclerosis in small trial – Reuters Health (free)

 

3 – Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: When DAA Treatment for Hepatitis C Fails, 3-Drug Regimen “Highly Effective” – Physician’s First Watch (free)

 

4 – Health Policy Trials: The Changing Face of Clinical Trials – New England Journal of Medicine (free)

 

5 – Prophylactic Acid-Suppressive Therapy in Hospitalized Adults: Indications, Benefits, and Infectious Complications – Critical Care Nurse (free)

Source: Restraint Urged Before Prescribing Acid-Suppressive Therapy in Hospitalized Patients – American Association of Critical-Care Nurses, via Newswise (free)

 

6 – Review: Chronic constipation: Update on management – Cleveland Clinic Journal of Medicine (free)

 

7 – Research transparency: 5 questions about open science answered – The Conversation (free)

 

8 – Viewpoint: No Shortcuts on the Long Road to Evidence-Based Genomic Medicine – JAMA (free)

“The need for evidence in genomic medicine is more important than ever” (RT @JAMA_current see Tweet)

 

9 – Editorial: Acting on Social Determinants of Health: A Primer for Family Physicians – American Family Physician (free) (RT @kennylinafp)

 

10 – Transient ischaemic attacks may have greater long-term impact than previously thought – NIHR Signal (free)

Original article: Ongoing impairments following transient ischaemic attack: retrospective cohort study – European Journal of Neurology (free)

 

Thu, June 1 – 10 Medical Stories of The Day!

1Jun
2017

 

1 – Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis – JAMA Cardiology (free) (RT @GreenlandRohan see Tweet)

Commentaries: Reducing blood pressure below recommended targets significantly reduces CVD, mortality risk – Clinical Advisor (free registration required) And New Review Supports Aggressive BP Targets – MedPage Today (free registration required)

Ideal blood pressure targets are controversial and recommendations vary across hypertension guidelines. This new meta-analysis suggests the risk of cardiovascular disease would be lowest with a systolic blood pressure between 120-124 mmHg.

 

2 – The UK Injection and Infusion Technique Recommendations 4th Edition – Forum for Injection Technique (FIT) (free PDF)

Commentary: New Guidance Focuses on Best Injection Practices for Diabetes – Medscape (free registration required)

Related guideline: New Insulin Delivery Recommendations – Mayo Clinic Proceedings (free)

 

3 – Review: Improving the Management of COPD in Women – Chest (free)

 

4 – World No Tobacco Day 2017 – Cochrane Evidence resources to support stop smoking efforts (free)

See also our coverage of World No Tobacco Day in our May 31 issue, see #1.

 

5 – Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free)

“Students used to take drugs to get high. Now they take them to get higher grades” (RT @ConversationUK see Tweet)

 

6 – Powerful New Ebola Vaccine Heads To Congo To Help Stop Outbreak – NPR Goats and Soda (free)

See also: DRC approves use of Ebola vaccine – CIDRAP (free) AND Ebola vaccine approved for use in ongoing outbreak – Nature News (free)

 

7 – State of the art review: Diagnosis and management of inflammatory bowel disease in children – The BMJ (free until 15 June)

 

8 – Cancer drugs are getting better and dearer – The Economist (a few articles per month are free) (RT @pash22 see Tweet)

See more articles and commentaries about “financial toxicity” of cancer treatments in our April 27 issue, see #8.

 

9 – A blood test threshold for diagnosing heart failure in general practice is reviewed – NIHR Signal (free)

Original article: Primary care REFerral for EchocaRdiogram (REFER) in heart failure: a diagnostic accuracy study (free)

“Most accurate diagnosis for heart failure in general practice came from using NTproBNP level at a low cut-off of ≥125 pg/ml” (RT @NIHR_DC see Tweet)

 

10 – Maternal and Fetal Outcomes of Anticoagulation in Pregnant Women With Mechanical Heart Valves – Journal of The American College of Cardiology (free)

Commentaries: Warfarin OK in Expectant Moms with Mechanical Heart Valve – MedPage Today (free registration required) AND Anticoagulation in Pregnant Women With Mechanical Valves – American College of Cardiology, Latest in Cardiology (free) (RT @keaglemd see Tweet)

In this meta-analysis, warfarin was associated with lower risk of adverse maternal outcomes, whereas LMWH was associated with lower risk of adverse fetal outcomes.

 

Wed, May 31 – 10 Medical Stories of The Day!

31May
2017

 

1 – World No Tobacco Day, 31 May 2017: Beating tobacco for health, prosperity, the environment and national development – World Health Organization (free)

Press release: World No Tobacco Day 2017: Beating tobacco for health, prosperity, the environment and national development (free)

See more on the Beating Tobacco Campaign in our May 29th issue, see #1.

 

2 – The British Society for Rheumatology Guideline for the Management of Gout – Rheumatology (free)

Source: BSR guideline: Urate-lowering drugs should be offered early in gout – Healio Rheumatology (free)

 

3 – Triple Therapy Versus Biologic Therapy for Active Rheumatoid Arthritis: A Cost-Effectiveness Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: In Rheumatoid Arthritis, Adding a Biologic Agent Before Trying Triple Therapy Likely Not Cost-Effective – Physician’s First Watch (free) AND Biologics before triple therapy not cost effective for rheumatoid arthritis – MedicalXpress (free) Triple Therapy More Cost-Effective Than MTX + Biologic in RA – Medscape (free registration required)

 

4 – Treatment of Osteoarthritis of the Knee: An Update Review – Agency for Healthcare Research and Quality (US) (Key messages and abstract – free)

See also: Executive Summary (free PDF) AND Full Report (free PDF)

Source: EvidenceAlerts

 

5 – Recommendations for the Use of Mechanical Circulatory Support: Ambulatory and Community Patient Care: A Scientific Statement From the American Heart Association (free PDF)

See also: News release (free) AND Top Ten Things to Know (free PDF)

Related: Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support: A Scientific Statement From the American Heart Association (free PDF) AND CPR in Patients With Mechanical Circulatory Support – American College of Cardiology, Latest in Cardiology (free)

 

6 – Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Carbon Monoxide Poisoning – American College of Emergency Physicians (free)

Source: First10EM – Articles of the month, May 2017 (free)

 

7 – Handshake-Free Zones Target Spread Of Germs In The Hospital – NPR (free)

 

8 – Healthcare Providers Shouldn’t Come to Work While Sick, but They Do — Here’s Why – HIV and ID Observations, Journal Watch Blog (free)

 

9 – Richard Lehman’s weekly review of medical journals – The BMJ Blogs (free)

 

10 – Draft Recommendation Statement: Adolescent Idiopathic Scoliosis: Screening – U.S. Preventive Services Task Force (free)

Commentary: USPSTF: Not Enough Evidence to Recommend Routine Scoliosis Screening – Physician’s First Watch (free)

 

Tue, May 30 – 10 Medical Stories of The Day!

30May
2017

 

1 – B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)

Commentary: Some heart attack patients may not benefit from beta blockers – University of Leads, via Science Daily (free)

Large cohort suggests there may be no benefit in continuing B-Blockers in patients who do not develop heart failure or ventricular dysfunction after myocardial infarction.

 

2 – A New Renaissance in Pericardial Diseases – Progress in Cardiovascular Diseases (special issue with series of review articles on the management of pericardial disease).

Source: Hospital Medicine Virtual Journal Club

1 – Introduction: A New Renaissance in Pericardial Diseases (free)

2 – Structure and Anatomy of the Human Pericardium (free)

3 – Pathophysiology of the Pericardium (free)

4 – Acute Pericarditis (free)

5 – Recurrent Pericarditis (free)

6 – Constrictive Pericarditis: A Practical Clinical Approach (free)

7 – Pericardial Effusions: Causes, Diagnosis, and Management (free)

8 – Pericardial Masses, Cysts and Diverticula: A Comprehensive Review Using Multimodality Imaging (free)

9 – Congenital Absence of the Pericardium (free)

10 – Surgical Management of Pericardial Diseases (free)

 

3 – Sat-fat bait and switch – ACP Internist (free)

Related: Backlash after report claims saturated fats do not increase heart risk – The Guardian (free)

Interesting and balanced point of view arguing against recent articles suggesting saturated fats are not that bad (April 27th issue, see #3).

 

4 – Review: Current guidelines on prevention with a focus on dyslipidemias – Cardiovascular Diagnosis & Therapy (free)

Review comparing current recommendations for the treatment of dyslipidemia.

 

5 – Science Needs a Solution for the Temptation of Positive Results – The New York Times (10 articles per month are free)

 

6 – Diagnosis creep: the new problem in medicine – MJA Insight (free)

Related: How to rein in the widening disease definitions that label more healthy people as sick – The Conversation (free)

 

7 – Updated tutorial: What is a Systematic Review? – PubMed Health (free) (RT @hildabast)

 

8 – Report: From Panic and Neglect to Investing in Health Security: Financing Pandemic Preparedness at a National Level – World Bank (free PDF)

Press release: After Ebola and Zika, Most Countries Still Not Prepared for a Pandemic (free)

Commentary: World Bank says most nations not ready for pandemic – CIDRAP (free)

 

9 – The tiny pill which gave birth to an economic revolution – BBC News (free)

A great read—and a powerful reminder that contraceptives are one of the best tools we have to drive economic growth” (RT @melindagates see Tweet).

 

10 – Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe – British Journal of Cancer (free)

Commentaries: Why your waist measurement can predict cancer risk – The Guardian (free) AND Large Waist Raises Cancer Risk – Medscape (free registration required)

 

Mon, May 29 – 10 Medical Stories of The Day!

29May
2017

 

1 – Preparing for the next WHO Campaign: World No Tobacco Day, 31 May 2017 – World Health Organization (free infographics, posters, banners, publications and other resources for the upcoming campaign)

See also: “Tobacco Endgame” policies in our May 12th issue, see #3.

See also: Smoking prevalence and attributable disease burden in 195 countries and territories in our April 7th issue, see #1.

“Wednesday 31 May is World No Tobacco Day. Tweet using #NoTobacco “Protect health, reduce poverty, promote development” (RT @gmacscotland see Tweet)

 

2 – Type 2 diabetes in adults: management – NICE Guideline (free)

See also: Algorithm for blood glucose lowering therapy in adults with type 2 diabetes (free PDF)

Source: UK NICE Elevates SGLT2 Inhibitors in Diabetes Guidance – Medscape (free registration required)

 

3 – Viewpoint: Direct-to-Consumer Medical Testing in the Era of Value-Based Care – JAMA (free)

See also a recent discussion on direct-to-consumer genetic testing in our April 10th issue, see #5

Others disagree: “Dissing every consumer medical test as “low value”. Sorry, that’s not true. It’s called paternalism” (RT @EricTopol see Tweet)

 

4 – The Weight Loss Trap: Why Your Diet Isn’t Working – Time (cover story) (free)

“The challenges of weight loss and obesity – really well addressed” (RT @EricTopol see Tweet)

 

5 – Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis – British Journal of Sports Medicine (free)

Commentary: Several non-drug options help with fatigue during, after cancer treatment – Reuters Health News (free)

 

6 –  Countries like German and Italy are adopting mandatory vaccination policies

Germany vaccination: Fines plan as measles cases rise – BBC Health News (free) AND German kindergartens must report parents for refusing vaccine advice under new law – Reuters Health News (free)

See also: Italy makes 12 vaccinations compulsory for children and related commentaries in our May 22nd issue, see #2.

 

7 – #ATS2017 – Antibiotic therapy for nearly one in four adults with pneumonia does not work – American Thoracic Society, via Science Daily (free) (RT @IDSAInfo see Tweet)

See also: Pneumonia Treatment Failure Rates High – Medscape (free registration required) AND Adults With Pneumonia Often Fail First Antibiotic – MedPage Today (free registration required)

 

8 – Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data – British Journal of General Practice (link to abstract – $ for full-text)

Commentaries: Cautions and caveats help buoy Guardian story on using high platelet count for cancer detection – HealthNewsReview (free) High blood platelet count ‘as good a cancer predictor as a lump in the breast’ – The Guardian (free)

Thrombocytosis seems to be a risk marker of cancer in adults, but questions remain about the clinical usefulness of these findings.

 

9 – New Guideline Summaries – National Guideline Clearinghouse (US):

1 – Systemic therapy of incurable gastroenteropancreatic neuroendocrine tumours – Cancer Care Ontario (free) AND 2 – Guidelines for the management of severe traumatic brain injury, 4th edition – Brain Trauma Foundation (free) AND 3 – American Gastroenterological Association Institute guideline on the management of Crohn’s disease after surgical resection – National Guideline Clearinghouse (free) AND 4 – Management of adult pancreatic injuries: a practice management guideline from the Eastern Association for the Surgery of Trauma – National Guideline Clearinghouse (free)

 

10 – Cancer Pain – Updated PDQ Cancer Information Summary, National Cancer Institute (US) (free)

 

Fri, May 26 – 10 Medical Stories of The Day!

26May
2017

 

1 – Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use – Circulation (link to abstract – $ for full-text)

Commentaries: Anabolic Steroid Use Linked With Myocardial Dysfunction and Accelerated Atherosclerosis – TCTMD (free) AND Chronic anabolic steroid use may damage heart – American Heart Association News (free)

“The findings are a public health concern, given that as many as 1% of young men, not all of them athletes, may use these agents” (from TCTMD above).

 

2 – The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections (free)

Related: Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference – World Journal of Emergency Surgery (free)

 

3 – Thrombolysis may reduce complications of deep vein thrombosis – NIHR Signal (free)

Original article: Thrombolysis for acute deep vein thrombosis – Cochrane Library (Link to abstract – $ for full-text)

Thrombolysis reduced post-thrombotic syndrome, but lead to more bleeding complications than standard anticoagulation. “Individuals with clots in the pelvis and thigh, which carry higher risk of complications, may be likely to gain most benefit”.

 

4 – Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection – NIHR Signal (free)

Original article: Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37 weeks or more) – Cochrane Library (Link to abstract – $ for full-text)

“Inducing labour within 24hrs may halve risk of infection in the womb when waters break from 37 weeks” (RT @NIHR_DC see Tweet)

 

5 – Diagnostic accuracy of post-mortem CT with targeted coronary angiography versus autopsy for coroner-requested post-mortem investigations: a prospective, masked, comparison study – The Lancet (free)

Editorial: Targeted coronary post-mortem CT angiography, straight to the heart (free)

Commentary: Digital autopsies should be standard for probable natural deaths, says study – The Guardian (free)

 

6 – American Society of Clinical Oncology (ASCO) 2017 Annual Meeting

Can cashews keep colon cancer patients alive? Study says yes — but cautions abound – STAT News (free) AND Reducing Risk After Cancer: Healthy Lifestyle (and Tree Nuts) – Medscape (free registration required)

 

7 – Recent articles on payment models published in JAMA

The Next Generation of Episode-Based Payments – JAMA (free) AND Value-Based Payment Models for Community Health Centers: Time to (Cautiously) Take the Plunge? – JAMA (free) AND Business Model–Related Conflict of Interests in Medicine: Problems and Potential Solutions – JAMA (free)

 

8 – Idiopathic pulmonary fibrosis in adults: diagnosis and management – NICE Guideline (free)

 

9 – Eating disorders: recognition and treatment – NICE Guideline (free)

 

10 – The lap band for weight loss is a tale of medicine gone wrong – VOX (free)

See also a recent study showing high complication rates of laparoscopic gastric band surgeries in our May 23rd issue (see #7)

 

Thu, May 25 – 10 Medical Stories of The Day!

25May
2017

 

1 – Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study – BMJ (free)

Recommended: New QRISK-3 2017 Calculator (free)

QRISK-3 risk prediction model was developed with data from 7.89 million patients in the derivation cohort and 2.67 million patients in the validation cohort. QRISK-3 includes more factors than QRISK2 to help enable doctors to identify those at most risk of heart disease and stroke. New risk factors include: 1) Chronic kidney disease, which now includes stage 3 CKD; 2) Migraine; 3) Use of corticosteroids; 4) Systemic lupus erythematosus (SLE); 5) Use of atypical antipsychotics; 6) Severe mental illness; 7) Erectile dysfunction; 8) and Systolic blood pressure variability.

 

2 – Stroke in Childhood: Clinical guideline for diagnosis, management and rehabilitation (2017) – Royal College of Paediatrics and Child Health (free PDF) (RT @bmj_latest see Tweet)

News release: New guidelines launched to help healthcare professionals and parents spot the signs of stroke in children (free)

Other resources: Stroke in Childhood: Clinical guideline for diagnosis, management and rehabilitation (2017) (free)

 

3 – Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial – JAMA (Link to abstract – $ for full-text)

Commentaries: Adding Anti-MRSA to Cephalexin No Better for Simple Cellulitis – Medscape (free registration required) AND Adding TMP/SMX to Cephalexin May Not Boost Cure Rate in Uncomplicated Cellulitis – Physician’s First Watch (free)

 

4 – Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Study confirms ‘flushing’ blocked fallopian tubes can improve fertility and reduce need for IVF – The Conversation (free) AND Can poppyseed oil help infertile couples conceive? – STAT News (free)

 

5 – Effect of a Modified Hospital Elder Life Program on Delirium and Length of Hospital Stay in Patients Undergoing Abdominal Surgery: A Cluster Randomized Clinical Trial – JAMA Surgery (free) (RT @PreetiNMalani see Tweet)

Commentary: Anti-delirium strategy reduces after-surgery confusion in elderly – Reuters Health (free)

Multicomponent nonpharmacologic interventions, including orienting communications, oral and nutritional assistance, and early mobilization reduced postoperative delirium by 56% and length of stay by 2 days.

 

6 – Very strict blood sugar control in critically ill children provides no benefit – NIHR Signal (free)

Original article (link to abstract – $ for full-text): Tight Glycemic Control in Critically Ill Children – New England Journal of Medicine (free)

 

7 – Human papillomavirus vaccines: WHO position paper, May 2017 – World Health Organization Weekly epidemiological record (free PDF)

“WHO update on HPV vaccine. Short summary – it’s very safe, very effective, widespread implementation recommended” (RT @michaelghead see Tweet)

 

8 – Factors Associated with Pediatric Mortality from Motor Vehicle Crashes in the United States: A State-Based Analysis – The Journal of Pediatrics (free PDF)

Commentaries: 43 Percent Of Children Who Died From Car Crashes Were Improperly Restrained – NPR Health News (free)

 

9 – Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (link to abstract – $ for full-text) (RT @Gas_Craic see Tweet)

Compared with culprit-only intervention, the complete revascularisation strategy may be superior due to lower proportions of long-term cardiovascular mortality, long-term revascularisation, and long-term non-fatal myocardial infarction, but these findings are based on evidence of very low quality”

 

10 – Angioedema in the emergency department: a practical guide to differential diagnosis and management – International Journal of Emergency Medicine (free) (RT @Gas_Craic see Tweet)

 

Wed, May 24 – 10 Medical Stories of The Day!

24May
2017

 

1 – World Health Assembly elects Dr Tedros Adhanom Ghebreyesus as new WHO Director-General – WHO Media Center (free)

Commentaries: World Health Organization gets first leader from Africa – Nature News (free) AND WHO elects first ever African director-general after tense vote – The Guardian (free) AND World Health Organization Elects a New Director General from Ethiopia – TIME (free)

 

2 – Electronic WHO Postpartum Family Planning Compendium – World Health Organization (free)

How to use it: Introducing the World Health Organization Postpartum Family Planning Compendium – International Journal of Gynaecology and Obstetrics (free)

This interactive website integrates essential guidance on postpartum family planning for clinicians, program managers, and policy makers.

 

3 – Review: Perioperative management of patients on direct oral anticoagulants – Thrombosis Journal (free)

 

4 – Guidelines for screening and management of late and long-term consequences of myeloma and its treatment – British Journal of Haematology (free)

Related: Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology (free)

 

5 – Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support: A Scientific Statement From the American Heart Association (free PDF)

See also: News release (free) AND Top Ten Things to Know (free PDF)

 

6 – Diet, Nutrition, Physical Activity and Breast Cancer – American Institute for Cancer Research (free PDF)

News release: Just one alcoholic drink a day increases breast cancer risk, exercise lowers risk – American Institute for Cancer Research, via EurekAlert (free)

Commentaries: Today’s alcohol and breast cancer headlines are wrong: Here’s how news reports could have done better – HealthNewsReview (free) AND ‘Half a glass of wine every day’ increases breast cancer risk – BBC Health News (free) AND Just One Drink a Day Raises Breast Cancer Risk – Medscape (free registration required)

 

7 – #ATS2017 – COPD National Action Plan – National Heart, Lung and Blood Institute (link to summary) PDF report available for download (free)

Source: ATS 2017: New COPD Action Plan Outlines Strategies for Improved Care – University of Michigan, via NewsWise (free)

 

8 – The Worst Fat in the Food Supply – The New York Times (10 articles per month are free)

See also a recent study and commentaries on the effects of trans-fat bans in our April 23rd issue (see #1)

Trans-fat bans seem to be reducing cardiovascular deaths.

 

9 – Richard Lehman’s weekly review of medical journals, 22 May 2017 – The BMJ Blogs (free)

 

10 – Association of Long-term Opioid Therapy With Functional Status, Adverse Outcomes, and Mortality Among Patients With Polyneuropathy – JAMA Neurology (free)

Editorial: Lack of Evidence for Benefit From Long-term Use of Opioid Analgesics for Patients With Neuropathy (free)

Commentaries: Long-Term Opioid Treatment Seems Only to Add Complications to Polyneuropathy – Physician’s First Watch (free) AND Long-Term Opioids May Not Help in Polyneuropathy – MedPage Today (free registration required)

“Patients had worse functional outcomes than controls; some became dependent” (from MedPage Today)

 

Tue, May 23 – 10 Medical Stories of The Day!

23May
2017

 

1- Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)

Editorial: Risks of Statin Therapy in Older Adults (free)

Commentaries: Older adults may not benefit from taking statins to prevent heart disease – Medical News Today (free) AND Pravastatin Doesn’t Improve Clinical Outcomes in Seniors – Physician’s First Watch (free)

Patients > 65 years with moderate hyperlipidemia and hypertension had no benefit from pravastatin for primary prevention. “A nonsignificant direction toward increased all-cause mortality with pravastatin was observed among adults 75 years and older” (HR 1.34; 95% CI, 0.98-1.84; P = .07).

 

2 – Fruit Juice in Infants, Children, and Adolescents: Current Recommendations – American Academy of Pediatrics (free)

Commentaries: Pediatricians Advise No Fruit Juice Until Kids Are 1 – NPR Health News (free) AND Pediatricians Say No Fruit Juice in Child’s First Year – New York Times (10 articles per month are free)

 

3 – #ATS2017 – Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial – JAMA (free)

Editorial: Home Noninvasive Ventilation to Reduce Readmissions for Chronic Obstructive Pulmonary Disease (free)

Commentary: Addition of Home Noninvasive Ventilation Tied to Fewer Readmissions After COPD Exacerbation – Physician’s First Watch (free)

 

4 – #ATS2017 – Directly Observed Therapy for Multidrug-Resistant TB Decreases Mortality – ATS 2017 Conference (free summary)

Directly Observed Therapy (DOT) for multidrug-resistant tuberculosis (MDR TB) was associated with a 77 percent decrease in mortality in observational study.

 

5 – Cancer screening in the United States, 2017: A review of current American Cancer Society guidelines and current issues in cancer screening – CA: A Cancer Journal for Clinicians (free)

 

6 – Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults – United European Gastroenterology Journals (free)

 

7 – Reoperation and Medicare Expenditures After Laparoscopic Gastric Band Surgery – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Following gastric band surgery, device-related reoperation common, costly – Science Daily (free) AND Safety, Effectiveness of Gastric Banding Called Into Question – Medscape (free registration required) AND 1 In 5 Gastric Band Surgeries Require Corrective Operations – American Council on Science and Health (free)

 

8 – American Urological Assn. Adds 5 More Unnecessary Practices to Choosing Wisely – Physician’s First Watch (free)

See also: Complete American Urological Association list with 15 Things Physicians and Patients Should Question – Choosing Wisely (free)

 

9 – Effects of the Informed Health Choices primary school intervention on the ability of children in Uganda to assess the reliability of claims about treatment effects: a cluster-randomised controlled trial – The Lancet (free registration required)

Commentaries: Belief in health bullshit is a global problem; a big study points to solutions – HealthNewsReview (free) AND This researcher may have discovered the antidote to health bullshit – VOX (free)

 

10 – Metformin, Lifestyle Intervention, and Cognition in the Diabetes Prevention Program Outcomes Study – Diabetes Care (link to abstract – $ for full-text)

Commentary: Long-term Metformin Use ‘Has No Cognitive Impact’ – Medscape (free registration required)

Contradicting previous studies suggesting a link between metformin use and cognitive impairment, possibly related to an impaired absorption of B12, this study has shown no such association.

 

Mon, May 22 – 10 Medical Stories of The Day!

22May
2017

 

1 – Time to Treatment and Mortality during Mandated Emergency Care for Sepsis – New England Journal of Medicine (free)

Commentary: Doctors have resisted guidelines to treat sepsis. New study suggests those guidelines save lives – STAT News (free)

“For every hour you delay antibiotics in sepsis, mortality goes up” (RT @CMichaelGibson see Tweet)

“Trauma: Golden Hour

Cardiology: Time is muscle

Neurology: Time is brain

Sepsis: Early antibiotics to survive”

(interesting remark by @CMichaelGibson see Tweet)

 

2 – Italy makes 12 vaccinations compulsory for children – BBC Health News (free) AND Italy passes law obliging parents to vaccinate children – Reuters Health (free)

Related: Embrace the facts about vaccines, not the myths – World Health Organization (free) AND World Immunisation Week: The Rise of Anti-Vaccine Movement and What it Means for Public Health – Independent (free) AND The riskiest vaccine? The one that is not given – Science (free)

“If children are not vaccinated by the age of six, the school starting age, their parents will be fined” (RT @anetrid see Tweet)

 

3 – Science Has Begun Taking Gluten Seriously – The Atlantic (free)

Original article: Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study – The BMJ (free)

“New research from Harvard and Columbia says gluten does not cause heart disease. Why is that even a question?”

 

4 – The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials – Nutrition Journal (free)

There has been a lot of controversy going on over the benefits and harms of saturated fats (April 27th issue, see #3) and it is difficult to interpret this new meta-analysis from randomized trials suggesting there may be no benefit from replacing saturated fats for unsaturated fats, since they contradict current guidelines and most epidemiological data from high-quality, long-term prospective cohort studies.

 

5 – Report: Healthier, fairer, safer: the global health journey 2007–2017 (free)

“New report on WHO’s role in Global Health by Sir Liam Donaldson” (RT @WHO see Tweet)

 

6 – Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease Study 2015 – The Lancet (free)

Commentaries: First-ever global study finds massive health care inequity – Institute for Health Metrics and Evaluatio (IHME) (free) AND Account for primary health care when indexing access and quality – The Lancet (free)

 

7 – Without action on antibiotics, medicine will return to the dark ages – The Guardian (free)

See more on “superbugs” in our February 28th issue (see #1), April 6th issue (see #9) and also in our Selection of news and education resources on Antibiotic Resistance

 

8 – Finally, Success Reducing Recurrent Stroke With PFO Closure – Medscape (free registration required)

Two randomized trials presented at the 3rd European Stroke Organization Conference (ESOC) 2017 showed that in carefully selected stroke patients in whom Patent Foramen Oval (PFO) was suspected to be a cause of their strokes, a reduction in recurrent stroke was observed with PFO closure.

 

9 – Report: #StatusOfMind Social media and young people’s mental health and wellbeing – Royal Society of Public Health (link to introduction – free PDF)

Commentaries: Instagram ‘worst for young mental health’ – BBC News (free) AND Instagram worst social media app for young people’s mental health – CNN news (free)

 

10 – Point of view: Is ‘Internet Addiction’ Real? – NPR Health News (free)

 

Fri, May 19 – 10 Medical Stories of The Day!

19May
2017

 

1 – Joint statement on public disclosure of results from clinical trials – World Health Organization (free)

News release: Major research funders and international NGOs to implement WHO standards on reporting clinical trial results (free)

Commentary: Industry leaders agree to implement UN agency’s standards on clinical trial reporting – United Nations News Centre (free)

“Funders of medical research & international NGOs to implement WHO standards on reporting clinical trial results”. “Today, on average 50% of Clinical Trials go unreported, according to several studies, often because the results are negative”. “Unreported trial results leave an incomplete & potentially misleading picture of the risks & benefits of vaccines, drugs and medical devices” (see Tweets)

 

2 – Health and Public Policy to Facilitate Effective Prevention and Treatment of Substance Use Disorders Involving Illicit and Prescription Drugs: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

News release: ACP issues recommendations to prevent and treat substance use disorders (free)

Commentary: Treat Addiction Like a Chronic Disease, ACP Recommends – AJMC (free)

 

3 – Viewpoint: Primary Care of Patients with Chronic Pain – JAMA (free)

“Opioids should be a therapy of last resort rather than the first choice as is often the case currently”.

 

4 – Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free)

Commentary: New Guideline Recommends Opioids Only as a Last Resort – Medscape (free registration required)

 

5 – The Best Intervention: Gavi CEO Seth Berkley’s Q&A, Part I – Global Health NOW (free)

“Perhaps just 10% of the world’s children receive all 11 vaccines recommended by the @WHO, says @GaviSeth, @Gavi CEO” (RT @ghn_news see Tweet)

 

6 – Tackling Ebola outbreak in remote Congo presents huge challenge: WHO – Reuters Health (free)

Related: As DRC Ebola cases grow, expert sees parallels to Guinea – CIDRAP (free) As Ebola outbreak grows, question of using vaccine becomes more urgent – Science (free) (RT @greg_folkers) AND Suspected Cases of Ebola Rise to 18 in Democratic Republic of Congo – The New York Times (10 articles per month are free)

 

7 – New Advice to Move More After a Concussion – The New York Times (10 articles per month are free)

Related: Consensus statement on concussion in sport—the 5th international conference on concussion in sport held in Berlin, October 2016 – British Journal of Sports Medicine (free) AND So, Tom Brady had a concussion. What does that mean? Your guide to the latest science – STAT News (free)

 

8 – Pressure ulcer prevention and treatment. Is ‘best practice’ evidence-based? – Cochrane Blogs: Evidence for Everyday Nursing (free) (RT @CochraneUK see Tweet)

Evidence for the treatment of pressure ulcers reviewed.

 

9 – Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Exercise and Dieting in Obese Older Adults (free)

Commentary: Aerobic Plus Resistance Exercise Best for Obese Older Adults – MedPage Today (free)

 

10 – Long-term oxygen therapy shows no benefit for moderate lung disease – NIHR Signal: Dissemination Centre Discover Portal (free)

Original article: A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation – New England Journal of Medicine (free)

Patients with stable COPD and moderate resting desaturation (Spo2, 89 to 93%) or moderate exercise-induced desaturation (during the 6-minute walk test, Spo2 ≥80% for ≥5 minutes and <90% for ≥10 seconds) don’t seem to benefit from supplemental oxygen therapy.

 

Thu, May 18 – 10 Medical Stories of The Day!

18May
2017

 

1 – Report: World Health Statistics 2017: Monitoring health for the SDGs – World Health Organization (free)

News release: Almost half of all deaths now have a recorded cause, WHO data show (free)

See also: World Health Statistics data visualizations dashboard – Monitoring health for the SDGs (free)

Commentaries: More Than Half of World’s Deaths Still Have No Recorded Cause – Scientific American (free) Reporting of Global Vital Death Statistics Improving: WHO – Medscape (free registration required)

 

2 – Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 – Journal of The American College of Cardiology (free)

Commentaries: Cardiovascular disease causes one-third of deaths worldwide – Institute for Health Metrics and Evaluation (IHME) (free) AND CVD Causes One-Third of Deaths Worldwide: Study Examines Global Burden of CVD From 1990 to 2015 – American College of Cardiology, Latest in Cardiology (free)

“New Study: Cardiovascular disease causes one-third of deaths worldwide” (RT @IHME_UW see Tweet)

 

3 – Systematic Review: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth – Cochrane Library (link to summary)

Source: A dose of corticosteroids benefit most women anticipating a preterm delivery – NIHR Dissemination Centre Discover Portal (free)

 

4 – Physician age and outcomes in elderly patients in hospital in the US: observational study – The BMJ (free)

Editorial: Physician age and patient outcomes (free)

Commentaries: Patients fare worse with older doctors, study finds – STAT News (free) AND Mortality Higher Among Inpatients Treated by Older Physicians – Medscape (free registration required) AND Study links physician age to patient mortality risk – EurekAlert (free)

 

5 – FDA Drug Safety Communication: FDA confirms increased risk of leg and foot amputations with the diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) (free)

Commentaries: FDA warns of foot, leg amputations with J&J diabetes drug – Reuters Health News (free) (RT @davidludwigmd) AND FDA Adds Boxed Warning to Canagliflozin for Increased Amputation Risk – Physician’s First Watch (free)

See also our May 11th issue with commentaries on a recent study showing that nearly 1 In 3 recent FDA drug approvals are followed by major safety concerns in the following years, see #10.

 

6 – What the World Will Learn from Chile’s Bold Policy to Curb Obesity – Bloomberg Philantropies Blog (free)

“Chile’s advertising policies stop high sugar, salt, fat products marketing to kids using cartoon characters” (RT @OPCAustralia see Tweet)

 

7 – The science behind One Health: at the interface of humans, animals, and the environment – Annals of the New York Academy of Sciences (free) (RT @greg_folkers see Tweet)

Related: One Health – Centers for Disease Control and Prevention (CDC) Resources (free) AND Advancing One Health Policy and Implementation Through the Concept of One Medicine One Science – Global Advances in Health and Medicine (free) AND One Medicine One Science: a framework for exploring challenges at the intersection of animals, humans, and the environment – Annals of the New York Academy of Sciences (free)

 

8 – Richard Lehman reviews the latest research in the top medical journals – The BMJ Blogs (free)

 

9 – Caffeine overdose is extremely rare — but here’s how it can happen – VOX (free) (RT @juliaoftoronto see Tweet)

 

10 – Review: Nutrition and metabolism in burn patients – Burns & Trauma (free)

 

Wed, May 17 – 10 Medical Stories of The Day!

17May
2017

 

1 – Global accelerated action for the health of adolescents (AA-HA!): Guidance to support country implementation – World Health Organization (free)

News release: More than 1.2 million adolescents die every year, nearly all preventable – World Health Organization (free)

Commentaries: How Many Teenagers Die Each Day … And Why – NPR Goats and Soda (free) AND 1.2 million adolescents’ deaths mostly preventable, report says – CNN (free) AND Pregnancy problems are leading global killer of ​​females aged 15 to 19 – The Guardian (free) AND Road accidents biggest global killer of teenagers – BBC News (free)

See also recently released Lancet Series making a case for global investment in the capabilities of adolescents, see #2.

 

2 – Cough in Children – Chest Guidelines

Use of Management Pathways or Algorithms in Children With Chronic Cough: CHEST Guideline and Expert Panel Report (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis: CHEST Guideline and Expert Panel Report (free)

See also other recent CHEST guidelines on the management of cough in Adults: Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND / Cough in the athlete (free) AND / Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND / Treatment of Unexplained Chronic Cough (free)

 

3 – WHO prepares experimental Ebola vaccine for possible first use in Democratic Republic of Congo – STAT News (free)

Related: WHO preparing authorization, logistics for Ebola vaccination in Congo if needed – Reuters Health (free)

 

4 – Viewpoint: How to rein in the widening disease definitions that label more healthy people as sick – The Conversation (free)

 

5 – Draft Recommendation Statement: Menopausal Hormone Therapy: Primary Prevention of Chronic Conditions – U.S. Preventive Services Task Force (free)

Source: USPSTF Recommendation Against HRT for Chronic Conditions Stands – Medscape (free registration required)

The USPSTF recommends against the use of combined estrogen and progestin for the prevention of chronic conditions in postmenopausal women”.

 

6 – Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial – JAMA (free)

Author interview video: Comparison of Intra-articular Triamcinolone vs Saline for Knee Osteoarthritis (free)

JAMA report video: Comparison of Intra-articular Triamcinolone vs Saline for Knee Osteoarthritis (free)

Source: Study: Intra-articular triamcinolone not effective for symptomatic knee osteoarthritis – Healio Rheumatology (free)

 

7 – Therapeutic Approach to Adult Fibrotic Lung Diseases – Chest (free)

Source: Hospital Medicine Virtual Journal Club

 

8 – Early Versus Delayed Feeding in Patients With Acute Pancreatitis: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Faster Feeding May Mean Faster Recovery in Pancreatitis – NewsWise (free) AND Early Feeding May Benefit Patients With Mild Pancreatitis – Medscape (free registration required).

For patients with mild to moderate pancreatitis, early feeding appears to be safe and may reduce length of hospital stay.

 

9 – Review: Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome – Gastroenterology Report (free)

Source: Critical Care Reviews Newsletter

 

10 – Review: Portal vein thrombosis in patients with cirrhosis – Gastroenterology Report (free)

Source: Critical Care Reviews Newsletter

 

Tue, May 16 – 10 Medical Stories of The Day!

16May
2017

 

1 – Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs: A Bayesian meta-analysis of survival data – Diabetes, Obesity and Metabolism (free)

Source: Review: Sulfonylureas are associated with overall mortality and CV events vs other antihyperglycemics – ACP Diabetes Monthly (free)

 

2 – Prevalence of Elevated Cardiovascular Risks in Young Adults: A Cross-sectional Analysis of National Health and Nutrition Examination Surveys – Annals of Internal Medicine (link to abstract – $ for full-text)

Source: Study Assesses ASCVD Risk in Non-Diabetic Adults – American College of Cardiology, Latest in Cardiology (free)

In the absence of diabetes, smoking or hypertension, most adult men younger than 40 years and adult women younger than 50 years are at low risk of cardiovascular disease (defined as < 5% in 10 years, usually not eligible for statin therapy) and may not benefit from cholesterol screening.

 

3 – BTS guideline for oxygen use in adults in healthcare and emergency settings – British Thoracic Society (free PDF via Critical Care Reviews)

 

4 – Updated: Will vaccine help curb new Ebola outbreak in the DRC? – Science (free)

“A comprehensive update on Ebola outbreak in DRC. Still unclear whether vaccine requested” (RT @sciencecohen see Tweet)

 

5 – Editorial: Drowning: a silent killer – The Lancet (free)

See also the World Health Organization report on Preventing Drowning in our May 3rd issue, see #2

 

6 – Report: Global Health and the Future Role of the United States – The National Academies of Sciences, Engineering, and Medicine (free)

Source: New report recommends priority actions to achieve global health security – EurekAlert (free)

 

7 – Switching from originator infliximab to biosimilar CT-P13 compared with maintained treatment with originator infliximab (NOR-SWITCH): a 52-week, randomised, double-blind, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentary: Celltrion Healthcare: Lancet Publishes Full Data-Set from Influential NOR-SWITCH Study – Business Wire (free)

 

8 – Choosing Wisely? Measuring the Burden of Medications in Older Adults near the End of Life: Nationwide, Longitudinal Cohort Study – The American Journal of Medicine (free)

See related study on the use of Medications of Questionable Benefit at the End of Life in our April 10th issue, see #8 and Deprescribing guidelines for elderly in our May 8th issue, see #4.

Source: Patient often prescribed potentially futile drugs in their final months of life – Science Daily (free)

“Nearly half of older adults in Sweden take 10 or more medications in their last months of life” (from Science Daily)

 

9 – Review: Recent advances in the management of variceal bleeding – Gastroenterology Report (free)

Source: Critical Care Reviews Newsletter

 

10 – Review: Hepatic encephalopathy – Gastroenterology Report (free)

Source: Critical Care Reviews Newsletter

 

Mon, May 15 – 10 Medical Stories of The Day!

15May
2017

 

1 – Guideline: Hip fracture: management – National Institute for Health and Care Excellence (NICE – UK) (free)

 

2 – Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)

See more on “Deprescribing” in our May 9th issue (see #7) and in our May 8th issue (see #4)

 

3 – Ebola virus disease: Democratic Republic of the Congo – World Health Organization (free)

Updated fact sheet: Ebola virus disease (free) (RT @greg_folkers)

See also: WHO confirms second Ebola case in Congo outbreak – Reuters Health (free) AND Ebola Outbreak Is Declared in Congo, With at Least 3 Dead – The New York Times (10 articles per month are free) AND Ebola: WHO declares outbreak in DR Congo – BBC News (free) AND Ebola: an outbreak has been confirmed in the DRC. Here’s what you need to know – VOX (free) AND The Confusion Over the New Ebola Outbreak – The Atlantic (free) (RT @juliaoftoronto)

 

4 – Cybercrime and healthcare

The hackers holding hospitals to ransom – The BMJ (free) AND NHS cyber-attack: GPs and hospitals hit by ransomware – BBC News (free) AND Disruption from cyber-attack to last for days, says NHS Digital – as it happened – The Guardian (free) AND Worldwide ransomware attack hits NHS hospitals – video – The Guardian (free) AND British Patients Reel as Hospitals Race to Revive Computer Systems – The New York Times (10 articles per month are free) AND Hackers Hit Dozens of Countries Exploiting Stolen N.S.A. Tool – New York Times (10 articles per month are free)

Many hospitals were affected around the world.

 

5 – Treatment Deintensification Is Uncommon in Adults With Type 2 Diabetes Mellitus: A Retrospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (link to abstract – $ for full-text)

Source: Treatment deintensification uncommon in type 2 diabetes – ACP Internist (free)

Editorial: Diabetes Mellitus Treatment Deintensification: When Well-Controlled Diabetes Mellitus Becomes Overcontrolled (free)

 

6 – Zika virus: Brazil says emergency is over – BBC (free) (RT @AthaliaChristie see Tweet)

Related: Brazil announces end to Zika public health emergency – The Guardian (free)

 

7 – Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference – World Journal of Emergency Surgery (free)

Source: Critical Care Reviews Newsletter

 

8 – 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines – Journal of the American College of Cardiology (free, and legal, PDF via Unpawall)

 

9 – Review: Infection in systemic lupus erythematosus, similarities, and differences with lupus flare – Korean Journal of Internal Medicine (free)

 

10 – Researchers have ditched the autism-vaccine theory. Here’s what they think actually causes it – VOX (free)

 

Fri, May 12 – 10 Medical Stories of The Day!

12May
2017

 

1 – Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline – The BMJ (free)

Commentaries: This orthopedic surgery is the world’s most common. But patients rarely benefit, a panel says – STAT News (free) AND Guideline Recommends Against Arthroscopy for Most Cases of Degenerative Knee Disease – Journal Watch (free) AND Arthroscopic Surgery Doesn’t Help With Arthritis Knee Pain – NPR Health News (free)

 

2 – Internet-Based Vestibular Rehabilitation for Older Adults With Chronic Dizziness: A Randomized Controlled Trial in Primary Care – Annals of Family Medicine (free)

See also: Balance retraining tool used in the study (free)

Commentaries: Online Rehabilitation Program Reduces Chronic Dizziness – Medscape (free registration required) AND Online Intervention Could Reduce Chronic Dizziness – Physician’s First Watch (free)

 

3 – Can Endgame Tobacco radically reduce cigarette smoking? – Healthy Debate (free) (RT @IrfanDhalla see Tweet)

Related: The tobacco endgame: a qualitative review and synthesis – Tobacco Control (free) AND It’s time to focus on an endgame for tobacco regulation – The Conversation (free)

“The “Tobacco Endgame” concept moves thinking away from the mere control of tobacco towards plans for ending the tobacco pandemic, and foresees a tobacco-free future” (from The Conversation)

 

4 – Review: Countering cognitive biases in minimizing low value care – The Medical Journal of Australia (free)

“How cognitive bias affects clinical decision making and what to do about it. Well written & useful” (RT @carissa_bon and @JulieLeask see Tweet)

 

5 – Using AI to Detect Cancer, Not Just Cats – Wired (free) (RT @EricTopol see Tweet)

Related: Is AI a threat or benefit to health workers? – CMAJ News (free)

More on Artificial Intelligence in Healthcare in our April 28Th issue (see #1) and in our April 10th issue (see #8)

 

6 – NCCN Guidelines Insights: Hepatobiliary Cancers, Version 1.2017 (free)

 

7 – Hodgkin Lymphoma Version 1.2017, NCCN Clinical Practice Guidelines in Oncology (free)

 

8 – Enhanced Recovery After Surgery Program Implementation in 2 Surgical Populations in an Integrated Health Care Delivery System – JAMA Surgery (free)

Invited commentary: Enhanced Surgical Recovery Through Enhanced Research From Integrated Health Systems (free)

See also our selection of Enhanced Recovery After Surgery Free Guidelines and Reviews

In this pre-post difference-in-differences study with 20 medical centers and 15849 surgical patients, implementation of ERAS protocols in patients undergoing elective colorectal resection and patients undergoing emergency hip fracture repair were associated with decreases in hospital length of stay and postoperative complication rates.

 

9 – Editorial: Vector control: time for a planetary health approach – The Lancet Global Health (free)

 

10 – Socioeconomic status as an effect modifier of alcohol consumption and harm: analysis of linked cohort data – The Lancet Public Health (free)

Invited commentary: Socioeconomic status and susceptibility to alcohol-related harm (free)

Commentary: Poorest at greater risk from heavy drinking, says study – BBC (free)

 

Thu, May 11 – 10 Medical Stories of The Day!

11May
2017

 

1 – Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation (link to abstract – free PDF available)

Sources: Guideline: Offer Cooling After Cardiac Arrest – MedPage Today (free) AND Body Cooling Recommended for Some Comatose Patients After Cardiac Arrest – Physician’s First Watch (free)

 

2 – Ten Principles of Good Prescribing – by J K Aronson, Centre for Evidence-Based Medicine (CEBM) (free)

 

3 – Estimating the future burden of multidrug-resistant and extensively drug-resistant tuberculosis in India, the Philippines, Russia, and South Africa: a mathematical modelling study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Drug Resistant TB Is Predicted To Steadily Spread In 4 Countries – NPR Goats and Soda (free) AND The Deadliest Form Of Tuberculosis Is Snowballing In Countries That Are Already Hard Hit – Huffington Post (free) AND Researchers Predict Increase in Drug-resistant TB – VOA News (free) AND Drug-resistant tuberculosis strains gain foothold – Science (free)

See also our coverage of #WorldTBDay in our March 24th issue

 

4 – Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies – The Lancet HIV (free)

Invited commentary: Improved life expectancy of people living with HIV: who is left behind? (free)

Source: Treatment now gives some HIV patients a normal life expectancy, study finds – STAT News (free)

 

5 – Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data – The BMJ (free)

Commentaries: Meta-Analysis: Just a Week of NSAID Use Tied to Increased Heart Attack Risk – Journal Watch (free) AND Common painkillers linked to increased risk of heart attack, study says – CNN (free) All NSAIDs Linked to Increased MI Risk – Medscape (free registration required)

Another study suggesting NSAIDs may be associated with increased cardiovascular risk.

 

6 – Meta-Analysis of Drug-Eluting Stents Versus Coronary Artery Bypass Grafting in Unprotected Left Main Coronary Narrowing – Journal of The American College of Cardiology (link to abstract – $ for full-text) (source: EvidenceAlerts)

Related recent meta-analysis: Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials – Circulation: Cardiovascular Interventions (free) AND Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis – BMC Medicine (free)

PCI with drug-eluding stents seems to be a safe alternative to CABG in Unprotected Left Main Coronary Artery Stenosis, but it is associated with higher rates of repeat revascularization.

 

7 – How To Do A Really Good Job Washing Your Hands – NPR Health News (free)

See also World Health Organization and Centers for Disease Control and Prevention (CDC) “Clean Hands” campaigns in our May 5th issue, see #2.

 

8 – Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline (free)

Source: Urologic Groups Offer New Prostate Cancer Management Guideline – Physician’s First Watch (free)

 

9 – Antibiotic Prescribing for Nonbacterial Acute Upper Respiratory Infections in Elderly Persons – Annals of Internal Medicine (link to abstract – $ for full-text)

Source: Half of all seniors who went to doctor for common cold prescribed unnecessary antibiotics – Science Magazine (free)

 

10 – Review: Current Trends in the Management of Gastroesophageal Reflux Disease – Gut and Liver (free PDF)

 

Wed, May 10 – 10 Medical Stories of The Day!

10May
2017

 

1 – Screening for Thyroid Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorial 1: The USPSTF Recommendation on Thyroid Cancer Screening: Don’t “Check Your Neck” (free)

Editorial 2: Cancer Screening, Overdiagnosis, and Regulatory Capture (free)

Editorial 3: How to Look for Thyroid Cancer (free)

Commentaries: No Symptoms, No Thyroid Screening, Says USPSTF – Medscape (free registration required) AND Don’t Screen For Thyroid Cancer, Task Force Says – NPR Health News (free) AND USPSTF Says No to Thyroid Cancer Screening – MedPage Today (free registration required)

The USPSTF recommended against screening for thyroid cancer in asymptomatic adults with “grade D” recommendation (Grade D = “The USPSTF recommends against the service. There is moderate or high certainty that the service has no net benefit or that the harms outweigh the benefits”).

 

2 – Meta-analysis: Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study – The BMJ (free)

High intakes of red and processed meat are associated with increased risks of all-cause mortality and death due to nine different causes.

 

3 – Meta-analysis: Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies – European Journal of Epidemiology (free)

Source: Eating cheese does not raise risk of heart attack or stroke, study finds – The Guardian (free)

Dairy seems to be neutral regarding risks of cardiovascular diseases and all-cause mortality.

 

4 – Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free) (RT @IrfanDhalla and @jendlake see Tweet)

 

5 – UK clinical practice guidelines for the management of gastrointestinal stromal tumours (GIST) – Clinical Sarcoma Research (free)

 

6 – Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)

 

7 – Viewpoint: Business Model–Related Conflict of Interests in Medicine: Problems and Potential Solutions – JAMA (free)

Source: Doctors should be paid by salary, not fee-for-service, argue behavioral economists – EurekAlert (free)

 

8 – Insights: Finding the Rare Pathogenic Variants in a Human Genome – JAMA (free)

“Prudent perspective on whole genome sequencing for healthy individuals” (RT @EricTopol see Tweet)

Technology allows sequencing of the entire human genome, but for healthy people, it currently has no clear clinical benefit and is inconsistent with a fundamental clinical axiom—to refrain from seeking uninterpretable and misleading information in patients or healthy individuals” .

 

9 – First opinion: The shadow of Big Tobacco looms over e-cigarettes and harm reduction – STAT News (free)

“Should we settle for lesser harms?”. “Examples of harm reduction strategies include providing methadone to heroin users… opening needle exchanges to prevent the spread of HIV and hepatitis among individual who inject drugs…and promoting e-cigarettes or smokeless tobacco as alternatives to smoking combustible cigarettes”.

 

10 – Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010 – JAMA (link to abstract – $ for full-text)

Commentaries: Nearly 1 In 3 Recent FDA Drug Approvals Followed By Major Safety Actions – Scientific American (free) AND One in Three Newly Approved Drugs Has Safety Issues – MedPage Today (free registration required) AND Safety Events Common in Newly Approved Drugs – Medscape (free registration required) AND New safety risks detected in one-third of FDA-approved drugs – The Washington Post (free) (RT @EricTopol see Tweet) AND One-Third Of New Drugs Had Safety Problems After FDA Approval – NPR Health News (free)

*Newer is not always better.

 

Tue, May 9 – 10 Medical Stories of The Day!

9May
2017

 

1 – Noncommunicable diseases: the slow-motion disaster – World Health Organization (free)

Related WHO resources: Other dimensions of the NCD crisis: from mental health, ageing, dementia and malnutrition to deaths on the roads, violence and disability (free) AND Tools for implementing WHO PEN (Package of essential noncommunicable disease interventions) (free) AND WHO’s work on NCDs (free)

Source: Noncommunicable Diseases: A Global ‘Slow-Motion Disaster’ – Medscape (free registration required)

 

2 – UN Global Road Safety Week, 8-14 May 2017 – World Health Organization

Press release 1: Fourth UN Global Road Safety Week 2017, 8-14 May 2017 (free)

Press release 2: Speed management key to saving lives, making cities more livable (free)

New WHO Report: Save LIVES: a road safety technical package (free)

WHO campaign: “Road Safety: Around 1.25 million people die every year on the world’s roads. Save lives, Slow Down!” (see Tweet) AND “Global Road Safety week: Excessive or inappropriate speed contributes to 1 in 3 road traffic fatalities, Slow Down!” (see Tweet).

 

3 – Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update from the American College of Physicians – Annals of Internal Medicine (free)

Commentaries: ACP Updates Guidelines on Treating Low Bone Density, Osteoporosis – Physician’s First Watch (free) AND New ACP Guidelines on the Treatment of Osteoporosis  – Medscape (free registration required)

Related guideline: UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free)

 

4 – Review: Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes – Circulation Research (free)

 

5 – Intravenous fluid therapy in adults in hospital – Updated National Institute for Health and Care Excellence (NICE – UK) Guideline (free)

 

6 – Type 2 diabetes in adults: management – Updated National Institute for Health and Care Excellence (NICE – UK) Guideline (free)

 

7 – Missed Opportunities for Deprescription: A Teachable Moment – JAMA Internal Medicine (free)

Related: This physician wants her patients to use fewer medications – The Washington Post (free)

For more on ”Deprescribing” see our May 8th issue, see #4

“Deprescription needs to be prescribed more” (RT @EricTopol see Tweet)

 

8 – Richard Lehman’s weekly review of medical journals – The BMJ Blogs (free)

 

9 – Review: Approach to the Patient with Hematochezia – Mayo Clinic Proceedings (free) (RT @HMVJC)

 

10 – Review: Fever of unknown origin (FUO) revised – Wiener klinische Wochenschrift (free) (RT @HMVJC)

 

Mon, May 8 – 10 Medical Stories of The Day!

8May
2017

 

1 – Conflict of Interest Theme Issue – JAMA

Theme Issue – Homepage (free)

Highlights (free)

Editorial: The Complex and Multifaceted Aspects of Conflicts of Interest (free)

Editorial: Conflict of Interest and Medical Journals (free)

Conflict of Interest: Why Does It Matter? (free)

Payments to Physicians: Does the Amount of Money Make a Difference? (free)

Why There Are No “Potential” Conflicts of Interest (free)

Addressing Bias and Conflict of Interest Among Biomedical Researchers (free)

Conflict of Interest and the Integrity of the Medical Profession (free)

Strategies for Addressing a Broader Definition of Conflicts of Interest (free)

Role of Leaders in Fostering Meaningful Collaborations Between Academic Medical Centers and Industry While Also Managing Individual and Institutional Conflicts of Interest (free)

Conflict of Interest Among Medical School Faculty: Achieving a Coherent and Objective Approach (free)

Teaching Medical Students About Conflicts of Interest (free)

Funding, Institutional Conflicts of Interest, and Schools of Public Health: Realities and Solutions (free)

Conflicts of Interest and Professional Medical Associations: Progress and Remaining Challenges (free)

Conflict of Interest in Practice Guidelines Panels (free)

Financial Conflicts of Interest in Continuing Medical Education: Implications and Accountability (free)

Challenges and Opportunities in Disclosing Financial Interests to Patients (free)

Business Model–Related Conflict of Interests in Medicine: Problems and Potential Solutions (free)

What Do Patients Think About Physicians’ Conflicts of Interest? Watching Transparency Evolve (free)

Public Disclosure of Payments to Physicians From Industry (free)

Managing Conflicts of Interest in Industry-Sponsored Clinical Research: More Physician Engagement Is Required (free)

Physicians, Industry Payments for Food and Beverages, and Drug Prescribing (free)

Conflict of Interest and the Role of the Food Industry in Nutrition Research (free)

How Should Journals Handle the Conflict of Interest of Their Editors? Who Watches the “Watchers”? (free)

Medical Journals, Publishers, and Conflict of Interest (free)

Conflict of Interest and Legal Issues for Investigators and Authors (free)

Is There a Conflict of Interest? (free)

 

2 – Research letter: Applicability of the IMPROVE-IT Trial to Current Patients With Acute Coronary Syndrome – JAMA Internal Medicine (link to abstract – $ for full text)

Source: Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today (free registration required)

Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)

Patients in clinical trials are often younger, healthier (with less comorbidities), better plugged in to the health care system, better educated and wealthier, indicating that the external validity or generalizability of much of the current evidence to real-world settings may be relatively weak.

 

3 – Medical News & Perspectives: The Paternal Epigenome Makes Its Mark – JAMA (free)

Related: Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype – American Journal of Stem Cells (free)

“Epigenetic changes may be the underlying mechanism by which paternal factors such as age, diet, weight, stress, and alcohol consumption contribute to a range of health outcomes in offspring including birth defects, behavioral problems, developmental disorders, obesity, diabetes, cardiovascular disease, and cancer”.

 

4 – Reducing inappropriate prescribing easier said than done – CMAJ News (free)

Related: Canadian Deprescribing Network (CaDeN) (free)

AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free)

 

5 – USPSTF recommendations: A 2017 roundup – Journal of Family Practice

 

6 – Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology (free)

 

7 – Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017 – Radiology (free)

Source: Management of Pulmonary Nodules Found Incidentally on Computed Tomography Scans – Journal Watch (free)

Incidental pulmonary nodules discovered outside the context of screening or cancer follow-up are increasingly common in clinical practice. The purpose of these updated recommendations is to reduce the number of unnecessary follow-up examinations while providing practical guidance on follow-up intervals for selected larger nodules.

 

8 – CDC updates Zika test guidance for pregnant women – CIDRAP (free)

Centers for Disease Control and Prevention (CDC) related resources: CDC Zika Interim Response Plan (free) (RT @greg_folkers) AND CDC updates guidance on interpretation of Zika testing results for pregnant women AND Outcomes of Pregnancies with Laboratory Evidence of Possible Zika Virus Infection in the United States AND Prolonged IgM Antibody Response in People Infected with Zika Virus: Implications for Interpreting Serologic Testing Results for Pregnant Women (free)

 

9 – Series: Acute Kidney Injury in the Intensive Care Unit

Fluid management in acute kidney injury – Intensive Care Medicine (free PDF)

Renal recovery after acute kidney injury – Intensive Care Medicine (free)

Diagnostic work-up and specific causes of acute kidney injury – Intensive Care Medicine (free PDF)

Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference – Annals of Intensive Care (free)

Source: Critical Care Reviews Newsletter

 

10 – Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology (free)

Source: Critical Care Reviews Newsletter

 

Fri, May 5 – 10 Medical Stories of The Day!

5May
2017

 

1 – Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery (free) (RT @jankluytmans and @CIDRAP_ASP see Tweet)

Invited commentary: Surgical Site Infection Prevention – What We Know and What We Do Not Know – JAMA Surgery (free)

Commentary: ‘Long-Awaited’ CDC Guidelines on SSI Prevention Released – Medscape (free registration required)

Related: Global guidelines on the prevention of surgical site infection 2016 – World Health Organization (free)

 

2 – World Hand Hygiene Day (May 5th, 2017)

World Health Organization: SAVE LIVES: Clean Your Hands 5 May 2017 AND Campaign Resources

Centers for Disease Control and Prevention (CDC): Clean Hands Count Campaign (free) AND Hand Hygiene in Healthcare Settings (free)

 

3 – First opinion: 8 things that excellent hospital doctors do – STAT News (free)

 

4 – Multiple-micronutrient supplementation for women during pregnancy – Cochrane Library (free summary – $ for full-text)

See also a recent landmark study on the subject in our March 27th issue, see #9.

Source: EvidenceAlerts

The findings of this systematic review support the effect of Multiple-micronutrient supplements with iron and folic acid in improving some birth outcomes.

 

5 – The World Is Not Ready for the Next Pandemic – TIME cover story (RT @HealthTalkUMN and @paimadhu see Tweet)

Related: The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) Seven reasons we’re at more risk than ever of a global pandemic – CNN (free)

 

6 – Handheld screen time linked with speech delays in young children – ScienceDaily (free)

Commentary on text and video: Letting a baby play on an iPad might lead to speech delays, study says – CNN (free)

See also more on the subject and screen time recommendations from the American College of Pediatrics in our April 10th issue, see #6.

“New research being presented at the 2017 Pediatric Academic Societies Meeting suggests the more time children under 2 years old spend playing with smartphones, tablets and other handheld screens, the more likely they are to begin talking later” (from ScienceDaily).

 

7 – Randomized controlled trial: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial – The Lancet (free)

Invited commentary: Weight management programmes of extended duration – The Lancet (free)

Commentary: Give overweight patients a year of weight-loss classes, say researchers – The Guardian (free)

In this trial with 1,267 overweight or obese participants an extended weight loss program (1 year) was more effective for weight loss and seems cost-effective in the longer term.

 

8 – Association of Donor Age and Sex With Survival of Patients Receiving Transfusions – JAMA Internal Medicine (link to abstract – $ required for full-text)

Source: Blood Donor Age, Sex Do Not Affect Outcomes After All – Medscape (free registration required)

After reviewing almost 1 million transfusions, the researchers concluded all donations are about the same” (RT @theheartorg see Tweet)

 

9 – Editor’s Choice: Give patients access to their medical records – The BMJ, by Fiona Godlee, editor in chief (free)

Patients are being empowered in decisions regarding their health care, and this is probably a tendency for the future.

 

10 – Correspondence: Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients – The New England Journal of Medicine (free)

Transplantation of HCV-infected-kidneys into uninfected recipients seems feasible in this era of direct-acting antiviral agents, maybe shortening waiting times for those willing to take the risk.

 

Thu, May 4 – 10 Medical Stories of The Day!

4May
2017

 

1 – Selection of patients for intra-arterial treatment for acute ischaemic stroke: development and validation of a clinical decision tool in two randomised trials – The BMJ (free)

New decision tool: MR CLEAN-R Registry (free)

This new clinical decision tool will improve the selection of patients with acute ischemic stroke who will benefit the most from intra-arterial treatment.

 

2 – Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (Link to abstract – $ for full-text)

Quick Take Video Summary: Bystander Efforts in Out-of-Hospital Cardiac Arrest (free)

Commentary: Bystander CPR and Defibrillation Are Associated with Better Long-Term Outcomes – Journal Watch (free)

In patients who have initially survived after out-of-hospital cardiac arrest, those who were submitted to bystander CPR and defibrillation had lower risk of brain damage, nursing home admission and death after one year when compared to patients who survived but were not submitted to bystander CPR.

 

3 – As scientists take to Twitter, study shows power of ‘visual abstract’ graphics – Scienmag (free) (RT @jdimick1 @UM_IHPI)

Have a look: Example of visual abstract and its benefits for engagement (Tweet)

Original article ($ for full-text): Visual Abstracts to Disseminate Research on Social Media: A Prospective, Case-control Crossover Study – Annals of Surgery

See also: an open-source primer on visual abstracts (free)

This new tendency might increase engagement with medical research.

 

4 – Cardiology groups issue guidance on heart failure – ACP Hospitalist

Key points from the recently published AHA Heart Failure Guideline (free)

See also our coverage on the new guidelines on our May 1st issue, see #2.

 

5 – Association Between Academic Medical Center Pharmaceutical Detailing Policies and Physician Prescribing – JAMA (link to abstract – $ for full-text)

Commentaries: Doctors Prescribe More Generics When Drug Reps Are Kept At Bay – NPR (free) AND Limiting Interactions with Pharma Reps Cuts Brand Name Drug Prescriptions – Physician’s First Watch (free)

See more about conflicts of interest in medicine in our yesterday’s issue, see #10.

 

6 – Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study – The BMJ (free)

Commentary: Gluten-Restricted Diets Seem Not to Lower Coronary Risk – Physician’s First Watch (free)

 

7 – Viewpoint: Breaking the Rules for Better Care – JAMA (free) (RT @gmacscotlan)

“Administrative burdens and complexity are alleged to be among the most costly forms of waste in US health care”. This comentary addresses the problem and provide a few suggestions for better care.

See more about the burden of administrative tasks in healthcare in our April 21st issue, see #5, and about physician’s burnout and clerical work in our April 24th issue, see #9.

 

8 – Interesting read: The Death of Expertise – The Federalist (free) (RT @wellcometrust and @MaryDixonWoods see Tweet)

This interesting commentary may as well be applied to the changing relationships between patients and doctors.

 

9 – Statins, Like All Medicines, Are Neither Good Nor Bad – By John Mandrola, MD (free)

I am sick of the “bad” drug frame. My latest fast-writing: Statins, Like All Medicines, Are Neither Good Nor Bad” (RT @drjohnm see Tweet)

 

10 – Urinary catheter care: what does the evidence say? – Cochrane Library (free)

How frequently should indwelling urinary catheters be changed? Are catheter washouts effective? Which type of catheter reduces rates of urinary tract infection?”. This post look at the evidence regarding urinary catheter care.

 

Wed, May 3 – 10 Medical Stories of The Day!

3May
2017

 

1 – World Asthma Day (May 2, 2017): Asthma Updated Fact Sheet – World Health Organization (free)

Related:  Cochrane Evidence resources related to World Asthma Day (free summaries)

 

2 – Report: Preventing drowning: an implementation guide – World Health Organization (free) (See @WHO Tweet 1 and Tweet 2)

Related publication: Global report on drowning: preventing a leading killer – World Health Organization (free)

 

3 – Embrace the facts about vaccines, not the myths – World Health Organization (free) (RT @gmacscotland see Tweet)

Related: The amazing power of vaccines, explained in 6 seconds – World Economic Forum (free) AND World Immunisation Week: The Rise of Anti-Vaccine Movement and What it Means for Public Health – Independent (free) (RT @LSHTMpress see Tweet)

See also our coverage on World Immunization Week in our April 25 issue, see #1.

 

4 – What is public health? Some reflections for teaching – Dr Graham Mackenzie, Consultant in Public Health (free)

 

5 – Systematic review: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library (free summary – $ for full-text))

The evidence so far suggests that PCSK9 inhibitor use probably leads to little or no difference in mortality and leads to a modest absolute risk reduction (often less than 1%) in cardiovascular events in high-risk patients.

 

6 – Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Commentaries: Fasting Studies Clash With Our Desire To Eat What We Want, When We Want It – NPR Health News (free) AND Fasting Every Other Day Does Not Lead to Greater Weight Loss – Physician’s First Watch (free) AND Same Weight Loss With Alternate-Day Fasting vs Cutting Calories – Medscape (free registration required) AND Alternate-Day Fasting Doesn’t Lead to Speedier Weight Loss – MedPage Today (free registration required)

Randomized trial with 100 patients showed no difference in weight loss between alternate-day fasting versus calorie restriction.

 

7 – Updated Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection – AIDSInfo (free)

 

8 – Second-Line Hormonal Therapy for Men With Chemotherapy-Naïve, Castration-Resistant Prostate Cancer: American Society of Clinical Oncology Provisional Clinical Opinion (free)

Source: ASCO Issues Guideline on Castrate-Resistant Prostate Cancer – Medscape (free registration required)

 

9 – Interesting read: Here’s What Your Future Doctor Visits Could Look Like – Fortune (free) (RT @EricTopol see Tweet)

According to this point of view “tomorrow’s office visit will increasingly take place everywhere but the office”, with a sharp increase in virtual visits and home visits, with doctors coming to patients.

 

10 – Viewpoint: Conflict of Interest: Why Does It Matter? – JAMA (free)

Editorial 1: The Complex and Multifaceted Aspects of Conflicts of Interest (free)

Editorial 2: Conflict of Interest and Medical Journals (free)

Source: Bruno Besen, MD

 

Tue, May 2 – 10 Medical Stories of The Day!

2May
2017

 

1 – Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free) (RT @CMAJ see Tweet)

Commentary: Use of Certain Antibiotics in Pregnancy Tied to Spontaneous Abortion – Physician’s First Watch (free)

In this nested case-control study, use of common antibiotics such as macrolides (excluding erythromycin), quinolones, tetracyclines, sulfonamides and metronidazole during early pregnancy was associated with an increased risk of spontaneous abortion.

 

2 – Effect of Using the HEART Score in Patients With Chest Pain in the Emergency Department: A Stepped-Wedge, Cluster Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

See also: HEART Score for Major Cardiac Events – MdCalc (free)

Commentaries: HEART Score for Chest Pain in ED Found to Be Safe, Cost-Effective – Physician’s First Watch (free) AND HEART Score Safely Informs Chest Pain Decisions in ED – Medscape (free registration required) AND HEART score to risk stratify patients with chest pain is safe but underutilized in the ED – ScienceDaily (free)

 

3 – Just started. Essentials of Global Health – Free Online Course from the Yale University and Coursera (RT @glassmanamanda)

 

4 – Expert consensus document: Echocardiography and lung ultrasonography for the assessment and management of acute heart failure – Nature Reviews Cardiology (free)

Source: Critical Care Reviews Newsletter

 

5 – Short review: CPAP Use in Obstructive Sleep Apnea: What a Cardiologist Needs to Know – American College of Cardiology, Latest in Cardiology (free)

 

6 – Review: Acute Respiratory Distress Syndrome – European Respiratory Review (free)

 

7 – Women with symptoms of a urinary tract infection but a negative urine culture: PCR-based quantification of Escherichia coli suggests infection in most cases – Clinical Microbiology and Infection (link to abstract – Free and legal PDF here – via @unpaywall)

Sources: The most reliable test and predictive entity for uncomplicated UTI is the patient’s symptoms – Emergency Literature of Note Blog (free) AND Negative Urine Culture + Symptoms = UTI in Most Women – MedPage Today (free registration required)

This study suggests that women with symptoms of uncomplicated cystitis and a negative urinary culture should be treated nonetheless.

 

8 – Prevalence of multidrug-resistant gram-negative bacteria among nursing home residents: A systematic review and meta-analysis – American Journal of Infection Control (free)

Sources: Study: Resistant gram-negative bacteria common in nursing homes – CIDRAP (free) (RT @IDSAInfo see Tweet) AND A quarter of nursing home residents are colonized with drug-resistant bacteria – EurekAlert (free)

 

9 – For Pregnant Women, Getting Serious About Whooping Cough – The New York Times (10 articles per month are free)

Related: Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis – Pediatrics (free) AND Study: Pertussis shot in pregnant moms protects newborns – CIDRAP (free) AND Get the Whooping Cough Vaccine While You Are Pregnant – Centers for Disease Control and Prevention (CDC) (free)

 

10 – More Evidence that Excessive Blood Pressure Lowering Can Heighten Cardiovascular Risk – Journal Watch (free)

Original article abstract ($ for full-text): Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials – The Lancet

See more about this article in our April 11 issue, see #8.

 

Mon, May 1 – 10 Medical Stories of The Day!

1May
2017

 

1 – Guidelines for treatment of drug-susceptible tuberculosis and patient care (2017 update) – World Health Organization (free) (RT @paimadhu see Tweet)

 

2 – 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure (free)

Commentaries: Societies Update Heart Failure Management Guidelines – Heart Failure Society of America (free) AND Societies Release HF Guideline Focused Update – American College of Cardiology, Latest in Cardiology (free)

 

3 – UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free)

 

4 – Adjuvant Systemic Therapy and Adjuvant Radiation Therapy for Stage I to IIIA Completely Resected Non–Small-Cell Lung Cancers: American Society of Clinical Oncology/Cancer Care Ontario Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

 

5 – Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association (free PDF)

News release: New guidance on heart failure tests can improve care – American Heart Association News (free)

 

6 – Management of Inherited Bleeding Disorders in Pregnancy: Green-top Guideline – Royal College of Obstetricians and Gynaecologists (free)

 

7 – Guidelines for the Economic Evaluation of Health Technologies: Canada – 4th Edition – Canadian Agency for Drugs and Technologies in Health (free)

News release: Guidelines for the Economic Evaluation of Health Technologies (free)

Commentary: New guidelines for evaluating health tech: New guide for economic analysis of drugs and technology – CMAJ News (free)

Best practices guidelines for conducting economic evaluations of health care technologies, so that the information produced is standardized and of high quality and can effectively inform health care decision-making.

 

8 – Screening for Preeclampsia: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Evidence Report and Systematic Review: Preeclampsia Screening (free)

Editorial 1: Early Identification of Pregnant Women at Risk for Preeclampsia (free)

Editorial 2: Screening for Preeclampsia and the USPSTF Recommendations (free)

Editorial 3: Preeclampsia and Hypertension – Courting a Long While: Time to Make It Official (free)

“The USPSTF recommends screening for preeclampsia in all pregnant women with blood pressure measurements throughout pregnancy”

 

9 – Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society (free)

Editorial: Gaining perspective on SUDEP: The new guideline (free)

Commentary: New guideline: Address GTCS frequency to reduce SUDEP risk – Clinical Neurology News (free)

 

10 – Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS, and SIOG (free)

News release: New guidance for management of aromatase-inhibitor related bone loss in breast cancer – Internationa Osteoporosis Foundation (free)

Source: Guidelines Issued on Managing Bone Loss Tied to Aromatase Inhibitor Therapy – Physician’s First Watch (free)

 

Fri, Apr 28 – Top 10 Medical News Stories!

28Apr
2017

 

1 – Automated Identification of Diabetic Retinopathy Using Deep Learning – Ophthalmology (free)

Source: Artificial Intelligence Shows Potential to Fight Blindness – NewsWise (free)

Related article: Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs – JAMA (link to abstract -$ for full-text)

Another study showing an artificial intelligence-based algorithm can be used with high reliability to screen for diabetic retinopathy, with cases referred to an ophthalmologist for further evaluation and treatment.

See more about how doctors might be affected by artificial intelligence in our April 10 issue, see #8.

 

2 – Text and video: The riskiest vaccine? The one that is not given – Science (free) (RT @greg_folkers)

 

3 – Systematic review: Tobacco packaging design for reducing tobacco use – Cochrane Library (link to summary – $ for full-text)

News release: Standardised tobacco packaging: will banning branding cut down smoking? (free)

See also: Standardised cigarette packaging is on its way, but will it reduce smoking? – The Guardian (free)

New evidence finds standardized cigarette packaging may reduce the number of people who smoke.

 

4 – A better way to care for the dying – The Economist (free) (RT @EricTopol see Tweet)

“How the medical profession is starting to move beyond fighting death to easing it”.

 

5 – Normal-Weight Central Obesity and Risk for Mortality – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Waist circumference stronger predictor of death risk than BMI – Haelio (free) AND Forget Your BMI and Focus on This Measurement Instead – TIME (free) AND Central Obesity Ups Mortality Across BMI Range – Physician’s Briefing (free) AND Central obesity may increase mortality risk from cardiovascular disease – Cardiovascular Business (free) AND People with a normal BMI who carry weight around the middle at greatest risk of death – HealthCanal (free)

 

6 – Advil, Motrin and other NSAIDs painkillers should be prescription only, Danish study says – Pittsburgh Post-Gazette (free) (RT @medpagetoday see Tweet)

Original article: Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case–time–control study – European Heart Journal – Cardiovascular Pharmacotherapy (free)

See more commentaries on this study in our March 17 issue, see #5.

 

7 – Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies – The BMJ (free)

Editorial: Opioid substitution treatment is linked to reduced risk of death in opioid use disorder – The BMJ (free)

Commentary: Opioid Substitution Therapy Associated with Reduced Mortality – Physician’s First Watch (free)

Opioid substitution treatment seems to be associated with decreased mortality.

 

8 – Viewpoint: Should we abandon routine blood tests? – The BMJ Opinion (free)

The practice of ordering routine blood tests for patients attending hospital regardless of clinical need is wasteful and potentially damaging, argue three doctors”.

 

9 – Viewpoint: Universal health coverage, priority setting, and the human right to health – The Lancet (free registration required)

 

10 – Sepsis can send a child to the brink of death within hours. A new coalition of hospitals is fighting back – STAT News (free)

 

Thu, Apr 27 – 10 Medical Stories of The Day!

27Apr
2017

 

1 – Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial – The Lancet (free)

Editorial: WOMAN: reducing maternal deaths with tranexamic acid (free)

Commentary: Overlooked Drug Could Save Thousands Of Moms After Childbirth – NPR Goats and Soda (free)

“Tranexamic acid reduced deaths of mothers caused by bleeding after childbirth by 1/3” (RT @LSHTMpress see Tweet)

 

2 – Guideline: Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association (free PDF)

News release: New guidance on heart failure tests can improve care – American Heart Association News (free)

 

3 – Editorial: Saturated fat does not clog the arteries: coronary heart disease is a chronic inflammatory condition, the risk of which can be effectively reduced from healthy lifestyle interventions – British Journal of Sports Medicine (free)

Commentaries on the editorial: Does saturated fats clog your arteries? Controversial paper says ‘no’ – CNN (free) AND The Battle Over the Causes of Cardiovascular Disease Heats Up! – By George Henderson and Grant Schofield (free) AND Backlash after report claims saturated fats do not increase heart risk – The Guardian (free) AND Expert reaction to editorial on saturated fat and heart disease – Science Media Centre (free)

Fat wars continue. New interesting but controversial editorial heats up the debate.

 

4 – Guidelines For Management Of Dyslipidemia And Prevention Of Cardiovascular Disease – American Association Of Clinical Endocrinologists And American College Of Endocrinology (free PDF) (RT @greg_folkers)

 

5 – Adherence to High-Intensity Statins Following a Myocardial Infarction Hospitalization Among Medicare Beneficiaries – JAMA Cardiology (link to abstract – $ for full-text)

Source: Heart Attack Survivors Often Fail to Take Statins – The New York Times (free)

In this cohort only 41.6% of patients aged 66 to 75 years continued taking statins as prescribed at 2 years.

 

6 – Five years wisely: A look at Choosing Wisely’s effort to reduce unnecessary medical care – HealthNewsReview (free) (RT @pash22 and @glassmanamanda see Tweet)

See also: Choosing Wisely initiative was launched 5 years ago in our April 5 issue.

 

7 – How to Fight Cancer (When Cancer Fights Back) – The Atlantic (free)

“Understanding how the disease evolves is the key to stopping it”.

 

8 – How hype can mislead cancer patients, families – CNN (free)

Related: Financial toxicity: 1 in 3 cancer patients have to turn to friends or family to pay for care – STAT News (free) AND Not Just Nausea And Vomiting: Cancer Docs Now Worry About ‘Financial Toxicity’ – WBUR (free)

“Cancer cost crisis forces tough choices”.

 

9 – Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW) – European Heart Journal (free)

Sources: Alcohol binge can upset heart’s rhythm, say researchers – BBC Health News (free) AND Binge Drinkers Beware: Study Finds Link Between Alcohol And Heart Arrhythmias – NPR (free) AND Oktoberfest: Downing Beers, Raising Heart Rates – Acute measurement in beer tents shows high rate of sinus tachycardia – MedPage Today (free registration required)

 

10 – After Knee or Hip Replacement, No Place Like Home – The New York Times (10 articles per month are free)

See also: Time to Rethink Inpatient Rehab After Knee Replacement? – The Rheumatologist (free)

Original article abstract ($ for full-text): Effect of Inpatient Rehabilitation vs a Monitored Home-Based Program on Mobility in Patients With Total Knee Arthroplasty: The HIHO Randomized Clinical Trial – JAMA (free)

The NYT commentary talks about the futility of some interventions currently used to postpone surgery and about the benefits of outpatient rehabilitation.

 

Wed, Apr 26 – 10 Medical Stories of The Day!

26Apr
2017

 

1 – World Malaria Day, 25 April 2017 – World Health Organization (free)

Press release: Prevent malaria – save lives: WHO push for prevention on World Malaria Day, 25th April (free)

WHO Reports 2017: A framework for malaria elimination (free) AND Malaria prevention works: let’s close the gap – World Malaria Day 2017 (free)

See also: WHO’s work on malaria (free)

Related: Mapping the End of Malaria – Gates Notes (free) (RT @glassmanamanda and @BillGates see Tweet) AND 7 Good Reads For #WorldMalariaDay – NPR Goats and Soda (free) AND Editorial: Is malaria elimination within reach? – The Lancet Infectious Diseases (free)

 

2 – Guideline: Screening for Preeclampsia: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Evidence Report and Systematic Review: Preeclampsia Screening (free)

Editorial 1: Early Identification of Pregnant Women at Risk for Preeclampsia (free)

Editorial 2: Screening for Preeclampsia and the USPSTF Recommendations (free)

Editorial 3: Preeclampsia and Hypertension – Courting a Long While: Time to Make It Official (free)

“The USPSTF recommends screening for preeclampsia in all pregnant women with blood pressure measurements throughout pregnancy”

 

3 – Eat, Sleep, Repeat: How Kids’ Daily Routines Can Help Prevent Obesity – NPR (free)

Observational data suggests regular evening meals, limited screen-viewing time and sleep routine may help prevent obesity in children.

 

4 – Updated Guideline: Prevention and Management of Cardiovascular Disease Risk in Primary Care – Toward Optimized Practice (TOP) Guidelines (free)

Practical guideline for primary care providers.

 

5 – Meta-analysis: Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis – British Journal of Sports Medicine (free)

Source: Exercise Could Benefit Cognition in Older Adults – Physician’s First Watch (free)

“Physical exercise interventions significantly improved cognitive function in adults older than 50 years, regardless of baseline cognitive status”.

 

6 – Accuracy of PECARN, CATCH, and CHALICE head injury decision rules in children: a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Sources: External Validation of Three Decision Rules for Pediatric Head Injury – Journal Watch (free) AND Best way to diagnose head injuries in children and minimize CT scans – ScienceDaily (free) AND PECARN, CATCH, CHALICE … or None of the Above? – By Ryan P. Radecki, MD, in Emergency Medicine Literature of Note (free)

The 3 decision rules performed well with negative predictive values >99%. The PECARN clinical decision rule was more sensitive and missed only 1 patient with clinically important traumatic brain injury, but was less specific, meaning more CTs would be required. These findings indicate that CT can generally be avoided if one of the prediction rules are negative.

 

7 – Cohort study: Use of azithromycin and risk of ventricular arrhythmia – Canadian Medical Association Journal (free)

Source: No Major Azithromycin Arrhythmia Risk in Huge European Cohort – Medscape (free registration required)

Contradicting a previous study (free) and a 2013 safety warning from the US Food and Drug Administration (free), this large cohort did not show an association between azithromycin and ventricular arrhythmia when compared to amoxicillin.

 

8 – Review: Aneurysmal Subarachnoid Hemorrhage: Diagnosis and Treatment – Deutsches Ärzteblatt international (free)

Source: Critical Care Reviews Newsletter (free)

 

9 – With yellow fever reaching Rio, official says Brazil prepared – CIDRAP (free)

 

10 – Assessment of Global Kidney Health Care Status – JAMA (free)

Source: One in 10 People Worldwide Have Chronic Kidney Disease – Medscape (free registration required)

Related: Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy – The Lancet (free registration required)

 

Tue, Apr 25 – 10 Medical Stories of The Day!

25Apr
2017

 

1 – World Immunization Week, 24-30 April 2017 – World Health Organization (free)

Press release: World Immunization Week 2017 (free)

See also: WHO’s work on immunization (free)

“Increasing immunization globally could save an additional 1.5 million people every year”.

 

2 – Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy – The Lancet (free registration required)

Chronic kidney disease is increasingly recognized as a global public health problem affecting as many as 10–15% of the population worldwide. It is associated with impaired quality of life and strongly reduced life expectancy. The article identifies key activities for the next 5-10 years to address the problem.

 

3 – Guideline: Community Mitigation Guidelines to Prevent Pandemic Influenza – United States, 2017 – CDC – MMWR (free)

Source: New CDC guidelines on flu pandemic measures reflect 2009 lessons – CIDRAP (free)

These new guidelines focus on nonpharmaceutical measures to fight and prevent influenza pandemics.

 

4 – Guideline: Recommendations on hepatitis C screening for adults – Canadian Task Force on Preventive Health Care (free)

News release: CTFPHC Releases Its First Hepatitis C Population-wide Screening Guideline (free)

See also: Summary of recommendations for clinicians and policy-makers (free) AND Clinician FAQ (free)

Commentary: Canada recommends against testing everyone for hepatitis C – Reuters Health (free) (RT @CMichaelGibson)

“Guideline recommends against screening for HCV in adults who are not at elevated risk”.

 

5 – Nursery Product-Related Injuries Treated in United States Emergency Departments – Pediatrics (free)

Source: Common Nursery Products Send Thousands of Children to Hospitals – The New York Times (10 articles per month are free) (RT @CMichaelGibson)

Baby carriers, mattresses, strollers, high chairs, changing tables, bath seats and other ordinary nursery products lead to injuries and emergency room visits for 66,000 children a year in U.S.

 

6 – Spend a Dollar on Drug Treatment, and Save More on Crime Reduction – The New York Times (10 articles per month are free)

 

7 – Committee Opinion: Hormone Therapy in Primary Ovarian Insufficiency – American College of Obstetricians and Gynecologists (free)

Source: Group Offers Guidance on Treating Primary Ovarian Insufficiency with Hormone Therapy – Physician’s First Watch (free)

 

8 – Empyema Guidelines Published – Physician’s First Watch (free)

Original article ($ for full-text): The American Association for Thoracic Surgery consensus guidelines for the management of empyema

 

9 – Richard Lehman’s weekly review of medical journals, 24 April 2017 – The BMJ Blogs (free)

 

10 – Relationship between hospital ward design and healthcare-associated infection rates: a systematic review and meta-analysis – Antimicrobial Resistance & Infection Control (RT @brhospitalist and @PreetiNMalani see Tweet)

Single-patient rooms and easily accessible hand rub dispensers located near the patient’s bed are the most effective measures.

 

Mon, Apr 24 – 10 Medical Stories of The Day!

24Apr
2017

 

1 – Report: Global hepatitis report, 2017 – World Health Organization (free)

Press release: New hepatitis data highlight need for urgent global response (free)

Related resources: WHO’s work on Hepatitis (free) AND Global health sector strategy on viral hepatitis, 2016-2021 (free)

The World Health Organization has released the first ever Global Hepatitis Report, with estimates on Hepatitis B and C burden, incidence and mortality. According to the report, deaths from viral hepatitis are increasing, with 1.34 million deaths in 2015, a number comparable to deaths caused by tuberculosis and HIV.

 

2 – FDA Safety Alert: Codeine and Tramadol Medicines: Drug Safety Communication – Restricting Use in Children, Recommending Against Use in Breastfeeding Women (free)

FDA Statement: New warnings about the use of codeine and tramadol in children & nursing mothers (free)

Commentaries on the statement: FDA: Codeine Now Contraindicated for Pain and Cough in Kids – Physician’s First Watch (free) AND Codeine cough syrup should not be given to kids, FDA warns – STAT News (free)

These drugs should not be used at all for children younger than 12 years, and their use should also be limited in some older children.

 

3 – Prospective cohort study: Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia – Stroke (free PDF)

Editorial: Sugar-Sweetened and Artificially Sweetened Beverages in Relation to Stroke and Dementia: Are Soft Drinks Hard on the Brain? – Stroke (free PDF)

Commentaries on the study: Diet soda and stroke & dementia news coverage: 3 key points weren’t always reported – HealthNewsReview (free – See Tweet) AND Stroke and dementia risk linked to artificial sweeteners, study suggests – The Guardian (free) AND A diet soda a day might affect dementia risk, study suggests – American Heart Association News (free)

This study has drawn a lot of attention from the media, but no firm conclusions can be made due to the observational nature of the study.

 

4 – Perspective: Focusing on High-Cost Patients — The Key to Addressing High Costs? – NEJM Catalyst (free) (RT @brhospitalist)

Related commentaries: Caring for High-Need, High-Cost Patients — An Urgent Priority – New England Journal of Medicine (free) AND Richard Smith: The challenge of high need, high cost patients – The BMJ Blogs (free) 

Playbook: Better Care for People with Complex Needs – Institute for Healthcare Improvement (free)

 

5 – Two new articles in The Lancet address important issues in global health economics.

Article 1: Evolution and patterns of global health financing 1995–2014: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries – The Lancet (free)

Article 2: Future and potential spending on health 2015–40: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries – The Lancet (free)

Invited commentary: Patterns of global health financing and potential future spending on health – The Lancet (free)

Commentary on the studies: What Country Spends the Most (And Least) On Health Care Per Person? – NPR Goats and Soda (free)

 

6 – Systematic review: Effect of Weight Reduction on Hemoglobin A1c in weight loss trials of Type 2 Diabetes Patients – Diabetes, Obesity and Metabolism (link to abstract – $ for full-text)

“Each 1kg reduction in weight loss trials associated with 0.1% reduction in HbA1c” (RT @kamleshkhunti see Tweet)

 

7 – Short review: Statistical significance vs. clinical significance – Students 4 Best Evidence Blog (free) (RT @CochraneUK see Tweet)

Related review: Reporting the findings: Absolute vs relative risk – HealthNewsReview (free) (See Tweet)

 

8 – Prospective, before-after cohort study: Standardized Criteria for Palliative Care Consultation on a Solid Tumor Oncology Service Reduces Downstream Health Care Use – Journal of Oncology Practice (free)

Editorial: Making the Right Thing Easier to Do: Standardized Integration of Oncology and Palliative Care – Journal of Oncology Practice (free)

Related Guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Commentaries on the study: Standardized Palliative Care Consults Cut Cancer Readmissions – Also, less chemotherapy after discharge – MedPage Today (free registration required) AND Standardized Cancer Palliative Care Consults Linked to Stronger Home-Based Support – AJMC (free)

Patients with at least one of the following 4 criteria: 1) advanced solid tumor; 2) prior hospitalization within 30 days; 3) hospitalization > 7 days; or 4) active symptoms – received automatic palliative care consultation. The rates of 30-day readmissions dropped from 35% to 18% and chemotherapy after discharge dropped from 44% to 18%.

 

9 – Survey and commentaries: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free)

Increased in clerical burden seems to be one of the leading causes, heavily influenced by expanded and more comprehensive use of electronic health records. More on the burden of administrative tasks in healthcare in our April 21 issue, see #5.

 

10 – Review: The efficacy of bedside chest ultrasound: from accuracy to outcomes – European Respiratory Review (free)

 

Fri, Apr 21 – Top 10 Medical News Stories!

21Apr
2017

 

1 – Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

See also: Researchers Propose Extending Diabetic Retinopathy Screening Interval – Physician’s First Watch (free) AND Research from long-term study advocates individualized eye screenings in type 1 diabetes – Diabetes.co.uk (free)

In patients who have had type 1 diabetes for 5 years, annual retinal examinations are currently recommended. Based on their findings, the authors suggest an individualized screening schedule, with less frequent screening for patients at low risk and more frequent screening for patients at higher risk, leading to decreased cost without delaying the diagnosis of clinically significant disease.

 

2 – Report: Building the foundations for sustainable development: a case for global investment in the capabilities of adolescents – The Lancet (free)

See also: Securing investments to realise the social and economic rights of adolescents (free) Our Future – Invest in Adolescent Health Now (free) AND Our future: a Lancet commission on adolescent health and wellbeing (all articles are free)

“Investing in adolescent health & education could bring 10-fold economic benefit” (RT @TheLancet see Tweet)

 

3 – Beyond Medication Reconciliation: The Correct Medication List – JAMA (free) (RT @AnilMakam see Tweet)

Achieving a “correct medication list” involves multiple levels of medication reconciliation. This viewpoint describes the main steps for achieving this goal.

 

4 – Association between active commuting and incident cardiovascular disease, cancer, and mortality: prospective cohort study – The BMJ (free)

Editorial: Active commuting is beneficial for health (free)

See also: Cycling to work can cut cancer and heart disease, says study – BBC News (free) AND Cycling to work: major new study suggests health benefits are staggering – The Conversation (free)

 

5 – Electronic Health Record Logs Indicate That Physicians Split Time Evenly Between Seeing Patients And Desktop Medicine – Health Affairs (link to abstract – $ for full-text)

Source: By the Numbers: Docs’ Logged-On Time Increases – MedPage Today (free registration required)

Related: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

“Electronic health records systems now account for about half of the average doctor’s day”

 

6 – Why the Menace of Mosquitoes Will Only Get Worse – The New York Times Magazine (RT @CIDRAP  and @marynmck see Tweet) (10 articles per month are free)

Related: Disease Burden Growing as Vector Insects Adapt to Climate Change – IPS (free) (source Global Health NOW Newsletter) AND UN Doc: Climate Change is New Challenge in Fighting Disease Outbreaks – MedPage Today (free registration required)

“Climate change is altering the environment in ways that increase the potential for viruses like Zika”.

 

7 – The Lancet Countdown: Tracking Progress on Health and Climate Change – The Lancet (free)

Editorial: Climate and health: joining up the pieces, scaling up the action (free)

 

8 – Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature – BMJ Open Diabetes Research & Care (free)

Sources: Climate Change Linked to Rising Diabetes Prevalence: Study – MedPage Today (free registration required) AND Is there a link between climate change and diabetes? – CNN (free)

“Association between climate change and diabetes?” (RT @kamleshkhunti see Tweet)

 

9 – Medical Alert! Climate Change Is Harming Our Health – Medical Society Consortium on Climate & Health (link to summary – free PDF available)

Sources: Medical Societies Come Together on Harms of Climate Change – Medscape (free registration required) AND Climate Change Already Affecting Human Health – Physician’s First Watch (free)

 

10 – Too many studies have hidden conflicts of interest. A new tool makes it easier to see them – VOX (free)

“Great news: PubMed is finally publishing info about funding sources/conflicts of interest on its abstracts” (RT @paimadhu and @juliaoftoronto see Tweet)

 

Thu, Apr 20 – Top 10 Medical News Stories!

20Apr
2017

 

1 – Changes in prices, sales, consumer spending, and beverage consumption one year after a tax on sugar-sweetened beverages in Berkeley, California, US: A before-and-after study – PLOS One (free)

Sources: First US sugar tax sees soft drink sales fall by almost 10%, study shows – The Guardian (free) (RT @kamleshkhunti see Tweet) AND Sugary Drink Sales Fizzled After Soda Tax – MedPage Today (free registration required)

Related articles and commentaries on the possible benefits of sugar taxes: W.H.O. Urges Tax on Sugary Drinks to Fight Obesity – The New York Times (10 articles per month are free) Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND Mexico’s sugar tax leads to fall in consumption for second year running – The Guardian (free) AND Why the government should tax unhealthy foods and subsidise nutritious ones – The Conversation (free)

 

2 – Updated Guideline: Alcohol-use disorders: diagnosis and management of physical complications – National Institute for Health and Care Excellence (NICE – UK) (free)

 

3 – Updated Guideline: Irritable bowel syndrome in adults: diagnosis and management – National Institute for Health and Care Excellence (NICE – UK) (free)

 

4 – Cost-effectiveness of Common Diagnostic Approaches for Evaluation of Asymptomatic Microscopic Hematuria – JAMA Internal Medicine (free)

Invited commentary: Asymptomatic Microscopic Hematuria – Rethinking the Diagnostic Algorithm (free)

Routine urinalysis for screening is not presently recommended by any major health organization, but asymptomatic microscopic hematuria is a common incidental finding. This study suggests that the combination of renal ultrasound and cystoscopy is the most cost-effective approach for the evaluation of these patients.

 

5 – β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies – JAMA Internal Medicine (link to abstract – $ for full-text)

See also: No Fetal Heart Risk from Mom’s Beta-Blocker Use – MedPage Today (free registration required)

 

6 – Syncope and Its Impact on Occupational Accidents and Employment: A Danish Nationwide Retrospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (free)

News release: Fainting spells may increase risk of workplace accidents, job loss – American Heart Association News (free)

See also: 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (free PDF) AND First fainting guidelines issued to diagnose life-threatening heart conditions – American Heart Association News (free)

 

7 – Australasian Society for Infectious Diseases: low value interventions – The Medical Journal of Australia (free) (RT @ChooseWiselyAU and @ASIDANZ see Tweet)

See also: Choosing Wisely initiative was launched 5 years ago in our April 5 issue.

The society has just released a selection of 5 low value interventions (details in the text):

 

– Prescribing antibiotics for asymptomatic bacteriuria.

– Taking a swab of a leg ulcer without signs of clinical infection and treating the patient with antibiotics against the identified bacteria.

– Treating upper respiratory tract infections with antibiotics.

– Investigation for fecal pathogens in the absence of diarrhea or other gastrointestinal symptoms.

– Ordering multiple serological investigations for patients with fatigue without a clinical indication or relevant epidemiology.

 

8 – Use of Medications of Questionable Benefit at the End of Life in Nursing Home Residents with Advanced Dementia – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

See also: Use of Medications of Questionable Benefit at the End of Life in Nursing Home Residents with Advanced Dementia – CBCNews (free) AND Many With Advanced Dementia Receiving Drugs of Uncertain Benefit – Medscape (free registration required)

“Too much use of meds of questionable benefit at the end of life: Just Stop.” (RT @DeeMangin see Tweet)

 

9 – Should You Take an Anticoagulant for AF? — Applying the 4 questions – Dr John M Blog (free) (@drjohnm see Tweet)

See also: anticoagulation for atrial fibrillation decision aid endorsed by NICE – National Institute for Health Care Excellence (UK) (free)

Very interesting post about how to practice shared decision making in patients with atrial fibrillation.

 

10 – Mortality Trends After a Voluntary Checklist-based Surgical Safety Collaborative – Annals of Surgery (link to abstract – free PDF available)

Sources: Global Health NOW Newsletter (free) AND South Carolina Hospitals Saw Surgery Deaths Drop After Implementing WHO Checklist – AJMC News (free) AND A simple checklist prevents deaths after surgery, a large new study suggests – The Washington Post (a few articles per month are free)

See also: WHO Surgical Safety Checklist – World Health Organization (free) AND A Surgical Safety Checklist to Reduce Morbidity and Mortality in a Global Population – New England Journal of Medicine (free)

 

Wed, Apr 19 – Top 10 Medical News Stories!

19Apr
2017

 

1 – Integrating neglected tropical diseases in global health and development: Fourth WHO report on neglected tropical diseases (free)

Press release: Unprecedented progress against neglected tropical diseases, WHO reports (free)

See also: Executive summary (free) AND Neglected No More – Gates Notes (free) AND The world’s assault on tropical diseases is working – STAT News (free)

 

2 – A guide to neglected tropical diseases prioritised by the World Health Organisation – Financial Times (free) (RT @NTDCOUNTDOWN See Tweet)

See also: Fact sheets relating to NTD – World Health Organization (free)

“The World Health Organisation has selected 18 as good candidates to be controlled”

 

3 – Rapid Rule-out of Acute Myocardial Infarction with a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

See also: High-Sensitivity Troponin T Test Rules Out AMI in ED – Medscape (free registration required) AND Meta-Analysis: Single Cardiac Troponin Test Plus ECG Can Quickly Rule Out MI – Physician’s First Watch (free)

“This analysis indicates that a nonischemic ECG and a single negative High-Sensitivity Cardiac Troponin T only misses about 1 in 100 myocardial infarctions – and can provide rapid, useful information in an assessment.” (from Physician’s First Watch commentary above).

 

4 – Comparison of Recommended Eligibility for Primary Prevention Statin Therapy Based on the US Preventive Services Task Force Recommendations vs the ACC/AHA Guidelines – JAMA (link to abstract – $ for full-text)

See also: ACC/AHA vs. USPSTF statin guidelines – Cardiology News (free)

Although recommended by most guidelines for individuals at high risk, there is still some controversy over prescribing statins for primary prevention and over what patients benefit the most – see related commentary: Cholesterol-lowering statin therapy for healthy people is not as simple as ‘yes’ or ‘no’ – The Pharmaceutical Journal (free)

Adherence to the 2016 USPSTF recommendations for statin therapy, compared with the 2013 ACC/AHA guidelines, could lead to a lower number of individuals (an estimated difference of 9.3 million individuals in the U.S. population) recommended for primary prevention statin therapy.

 

5 – Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring – JAMA (link to abstract – $ for full-text)

Contradicting a previous study showing increased risk of autism with antidepressant use during pregnancy (free), this large retrospect cohort study of 1 580 629 Swedish offspring did not show an association of antidepressant use during pregnancy and autism or other neurodevelopment problems.

 

6 – Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial) – The BMJ (free)

A single dose of 8 mg intravenous dexamethasone at induction of anesthesia reduced postoperative nausea and vomiting with no increase in adverse events.

 

7 – Maternal asthma: Management strategies – Cleveland Clinic Journal of Medicine (free)

 

8 – Why it’s a bad idea to space out your child’s vaccination shots – The Washington Post (a few articles per month are free)

“Splitting immunizations into several visits only increases children’s stress” (RT @IDSAInfo see Tweet)

 

9 – The 2017 Atlas of Sustainable Development Goals: a new visual guide to data and development – The World Bank (free) (RT @glassmanamanda and @St_Klingebiel see Tweet)

With over 150 maps and data visualizations, the new publication charts the progress societies are making towards the United Nations 17 Sustainable Development Goals.

 

10 – Preventing Sports Injury and Illness: Key Resources for Family Physicians – American Family Physician (free)

Selection of resources for primary care providers to improve their ability to prevent and treat injuries from sports and physical activity.

 

Tue, Apr 18 – Top 10 Medical News Stories!

18Apr
2017

 

1 – WHO Approves World’s First-Ever Dengue Vaccine – TIME (free) (RT @Onisillos and @JoanneLiu_MSF)

“For general background take a look at The Lancet Infectious Diseases Dengue series” (all articles are free) (RT @Onisillos see Tweet) 1 – Disease and economic burdens of dengue; 2 – Prevention and control of dengue – the light at the end of the tunnel; and 3 – Dengue: knowledge gaps, unmet needs, and research priorities

“World Health Organization Approves Dengue Vaccine: still lots of challenges ahead: it needs three injections & price” (RT @JoanneLiu_MSF see Tweet)

 

2 – Changes in the Employment Status and Risk of Stroke and Stroke Types – Stroke (Free PDF)

News release: Japanese study: Unemployment may increase stroke risk – American Heart Association News

Source: STAT Newsletter

 

3 – Non-Small Cell Lung Cancer – NCCN Clinical Practice Guidelines in Oncology (free)

 

4 – New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

Source: Critical Care Reviews Newsletter

 

5 – The Cost of Not Taking Your Medicine – The New York Times (10 articles per month are free)

According to the commentary, the lack of adherence to prescribed medications is estimated to cause approximately 125.000 deaths, at least 10 percent of hospitalizations and cost the American health care system between $100 billion and $289 billion a year.

 

6 – Too Clean for Our Children’s Good? – The New York Times (10 articles per month are free)

According to the “hygiene hypothesis”, some exposure to germs and microorganisms might be good for us because it helps develop the immune system. 

 

7 – The Breastfeeding-Friendly Pediatric Office Practice – American Academy of Pediatrics (free)

Source: AAP: Pediatricians Should Support Breastfeeding Moms – MedPage Today (free registration required)

Recent recommendation from another organization: Breastfeeding: Primary Care Interventions – U.S. Preventive Services Task Force (free)

Summary of USPSTF recommendations: Primary Care Interventions to Support Breastfeeding: Recommendation Statement – American Family Physician (free)

The American Academy of Pediatrics and the U.S. Preventive Services Task Force have issued recommendations for promoting and supporting breastfeeding.

 

8 – Association Between Hospitals’ Engagement in Value-Based Reforms and Readmission Reduction in the Hospital Readmission Reduction Program – JAMA Internal Medicine (link to abstract – $ for full-text)

Sources: Value-Based Reforms Linked to Readmission Reductions – Medscape (free registration required) AND Richard Lehman’s weekly review (free – see below)

A program of incentives (Medicare Hospital Readmission Reduction Program in the US) was effective in reducing 30 day readmissions following infarction, heart failure, and pneumonia.

 

9 – Richard Lehman’s weekly review of medical journals, 17 April 2017 – The BMJ Blogs (free)

 

10 – Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE) – The BMJ (free)

See also: Insulin pump didn’t improve glycemic control compared to training on injections – ACP Diabetes Monthly (free)

 

Mon, Apr 17 – Top 10 Medical News Stories!

17Apr
2017

 

1 – Hospital costs in relation to body-mass index in 1.1 million women in England: a prospective cohort study – The Lancet (free)

Related commentary: The costs of overweight – The Lancet (free)

“Every 2 kg/m2 increase in BMI associated with a 7.4% increase in annual hospital costs” (RT @ZaherToumi see Tweet)

 

2 – Can machine-learning improve cardiovascular risk prediction using routine clinical data? – PLOS One (free)

See also: Self-taught artificial intelligence beats doctors at predicting heart attacks – Science (free)

“When expert MD guidelines are outperformed by machine learning for heart risk prediction” (RT @EricTopol see Tweet)

 

3 – A New, More Rigorous Study Confirms: The More You Use Facebook, the Worse You Feel – Harvard Business Review (free) (RT @EricTopol see Tweet)

Original article abstract ($ for full-text): Association of Facebook Use With Compromised Well-Being: A Longitudinal Study – American Journal of Epidemiology

 

4 – Amsterdam’s solution to the obesity crisis: no fruit juice and enough sleep – The Guardian (free) (RT @DrAseemMalhotra see Tweet)

“The city is successfully fighting fat by promoting tap water in its schools, along with healthy cooking classes and a ban on fast food sponsorship”

 

5 – The Ebola outbreak, 2013–2016: old lessons for new epidemics – Philosophical Transactions of the Royal Society B (free) (RT @royalsociety see Tweet)

This article is part of the themed issue ‘The 2013–2016 West African Ebola epidemic: data, decision-making and disease control’ (all articles are free)

Comprehensive review of the latest Ebola outbreak with lessons learned and recommendations for future epidemics.

 

6 – Integrating Clinical Research into Epidemic Response: The Ebola Experience (2017) – National Academies of Sciences, Engineering, and Medicine (Free Download – PDF)

Source: New report charts ways to expedite critical research during epidemics – STAT News (free)

 

7 – Yellow Fever – Once Again on the Radar Screen in the Americas – New England Journal of Medicine (free)

See also: Is Yellow Fever Knocking At Our Door? – NPR (free) AND ‘We didn’t expect this’: A historic yellow fever outbreak spreads in Brazil – STAT News (free)

 

8 – CSH (Chinese Society of Hepatology) guidelines for the diagnosis and treatment of drug-induced liver injury (free)

 

9 – Life after breast, prostate, and colon cancer: Primary care’s role – Cleveland Clinic Journal of Medicine (free)

 

10 – Diagnosis and management of psoriasis – Canadian Family Physician (free)

 

Fri, Apr 14 – 10 Medical Stories of The Day!

14Apr
2017

 

1 – Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Mortality and Cardiovascular Disease in Diabetes (free)

Large cohort showing the long-term cardiovascular outcomes in patients with diabetes.

 

2 – Ten years in public health 2007-2017 – World Health Organization (free)

WHO has launched a report that chronicles the evolution of global public health over the last decade. The first chapter examines WHO’s key role in promoting universal health coverage (free). The full series will be published over the next 6 weeks.

 

3 – Radical increase in water and sanitation investment required to meet development targets – World Health Organization (free)

See also: WHO’s work on water, sanitation and hygiene (free) AND WHO’s work on public health, environment and social determinants of health (free)

 

4 – Screening for Endocrine Hypertension: An Endocrine Society Scientific Statement (free)

Source: Screen for Endocrine Hypertension, Endocrine Society Says – Medscape (free registration required)

“The statement provides guidance on screening for 15 hormonal disorders that present with hypertension and that can be potentially cured with surgery or treated with medication” (from Medscape commentary above).

 

5 – European Association of Urology releases its 1st thromboprophylaxis guideline (free)

 

6 – Procedure-specific Risks of Thrombosis and Bleeding in Urological Cancer Surgery: Systematic Review and Meta-analysis – European Urology (free)

“Extended thromboprophylaxis is warranted in some procedures (eg, open and robotic cystectomy) but not others (eg, robotic prostatectomy without pelvic lymph node dissection in low-risk patients)

 

7 – Procedure-specific Risks of Thrombosis and Bleeding in Urological Non-cancer Surgery: Systematic Review and Meta-analysis – European Urology (free)

“Extended prophylaxis is warranted for some procedures (eg, kidney transplantation procedures in high-risk patients) but not others (transurethral resection of the prostate and reconstructive female pelvic surgery in low-risk patients)”

 

8 – Four reasons why we shouldn’t forget about Zika – The Conversation (free)

 

9 – Recorded childhood cancers rise by 13% worldwide, study finds – The Guardian (free)

Original articles: International incidence of childhood cancer, 2001–10: a population-based registry study – The Lancet Oncology (free) AND Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries – The Lancet Haematology (free) Related commentary: Issues raised by the incidence and survival of childhood cancers (free)

 

10 – ASCO has just published 3 guidelines on the management of pancreatic cancer:

1 – Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (free) AND 2 – Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Summary (free) AND 3 – Locally Advanced Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Summary (free)

 

Thu, Apr 13 – 10 Medical Stories of The Day!

13Apr
2017

 

1 – Hospital Admissions for Myocardial Infarction and Stroke Before and After the Trans-Fatty Acid Restrictions in New York – JAMA Cardiology (link to abstract – $ for full-text)

Sources: Banning trans fats in New York prevented thousands of heart attacks, study finds – STAT News (free) AND Trans Fat Bans Tied to Fewer Heart Attacks and Strokes – The New York Times (10 articles per month are free)

Other localities might consider doing the same as well.

 

2 – Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study – The BMJ (free)

Corticosteroids, even if used for short periods of time, seems to be associated with significant morbidity and mortality. In this retrospective cohort with 1.5 million adults, the incidence of acute adverse events (sepsis, venous thromboembolism, fracture) increased by twofold to fivefold above background rates.

 

3 – Prostate Cancer Screening – Conflicting views on the new USPSTF draft recommendations

In favor of screening: New Official Prostate Cancer Screening Guidelines Announced: Too Little, Too Late? – Forbes (free) AND Federal Task Force Softens Opposition To Routine Prostate Cancer Screening – NPR

Against screening: The new recommendations for prostate cancer screenings are a bad deal – STAT News (free)

See also: Original USPSTF draft recommendations and related commentaries in yesterday’s issue

 

4 – Childhood cancers: 2 new studies on international incidence and survival (RT @TheLancet see Tweet)

Childhood cancer: International incidence of childhood cancer, 2001–10: a population-based registry study – The Lancet Oncology (free)

Childhood leukemia: Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries – The Lancet Haematology (free)

Related commentary: Issues raised by the incidence and survival of childhood cancers (free)

 

5 – Screening to Prevent Invasive Cervical Cancer: ASCO Resource-Stratified Clinical Practice Guideline (free)

“The ASCO guidelines outline the minimum standards for HPV-based screening for each resource strata; additional and more frequent screening may be added as the resources become available”.

 

6 – Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Due to a recent study showing a 2,5 month increase in median overall survival, the doublet regimen of gemcitabine and capecitabine seems to be preferred in the absence of concerns for toxicity or tolerance.

 

7 – The Patients Were Saved. That’s Why the Families Are Suing – The New York Times (free)

“Historically, the practice has been “if in doubt, err on the side of aggressive, life-sustaining treatment,””. That might be changing.

 

8 – Famine now threatens 20 million people – more than at any time since World War II – Washington Post (RT @AthaliaChristie and @wpjenna)

 

9 – Why Chinese Scientists Are More Worried Than Ever About Bird Flu – NPR Goats and Soda

Source: Global Health NOW Newsletter

H7N9 is a very deadly virus, killing around a third of the people who have contracted it. The virus has proved an ability to mutate quickly and researchers are concerned that a future mutation could make them to spread more easily among humans.

 

10 – Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults – PLOS Medicine (free)

Source: Fresh Fruit Protects Against Diabetes, Complications – MedPage Today (free registration required)

 

Wed, Apr 12 – 10 Medical Stories of The Day!

12Apr
2017

 

1 – Prostate Cancer Screening Draft Recommendations – U.S. Preventive Services Task Force (free)

Viewpoint: The US Preventive Services Task Force 2017 Draft Recommendation Statement on Screening for Prostate Cancer: An Invitation to Review and Comment – JAMA (free)

See also: Should you get screened for prostate cancer? We break down the latest advice – STAT News (free)

For those aged 55 to 69 it recommends “informed, individualized decision making based on a man’s values and preferences”. According to a useful infographic from the draft recommendations, the benefits are likely small. For every 1000 men offered PSA based screening over a period of 10-15 years, the test would avoid cancer spreading in 3 men and death from prostate cancer in 1-2 men, with the undesired consequences of false positives and subsequent procedures in many patients.

 

2 – Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free)

Related commentary: Tallying the bills of mortality from air pollution (free)

4.2 million deaths globally were attributable to fine particles and another 254 000 to surface ozone in 2015. The article also has details on country-specific deaths and disability-adjusted life-years from 1990 through 2015.

 

3 – How Many Pills Are Too Many? – The New York Times (10 articles per month are free)

“Evidence has mounted about the dangers of taking multiple, perhaps unnecessary, medications” (from Tweet)

 

4 – The hospital of tomorrow in 10 points – Critical Care (free)

This is the first article in a new thematic series about the future of critical care (free)

 

5 – EULAR revised recommendations for the management of fibromyalgia – Annals of Rheumatic Diseases (free)

Source: EULAR Revised Recommendations for the Management of Fibromyalgia – Medscape (free registration required)

 

6 – Management of Osteoarthritis of the Hip – American Academy of Orthopedic Surgeons (free PDF)

Source: AAOS releases new clinical practice guideline for osteoarthritis of the hip – Medical Express (free)

 

7 – New ILAE Epilepsy Classification Published – Medscape (free registration required)

Position paper: Operational classification of seizure types by the International League Against Epilepsy (free)

Practical manual: Instruction manual for the ILAE 2017 operational classification of seizure types (free)

“For the first time in 30 years, an epileptic seizures classification update” (RT @MedscapeNeuro see Tweet)

 

8 – Vitamins and the Failure of Free-Market Health – The Atlantic (free)

“The booming dietary-supplement industry is plagued by outlandish claims, undermining credible science, and seeding confusion”.

 

9 – Effect of Baseline Nutritional Status on Long-term Multivitamin Use and Cardiovascular Disease Risk – JAMA Cardiology (link to abstract – $ required for full-text)

See also: Multivitamins may not improve heart health in men – UPI (free) AND Other recent commentary on multivitamins: Multivitamins a waste of money and just create ‘very expensive urine’ – The Guardian (free)

“Multivitamin use does not prevent major CV disease events in men, regardless of baseline nutritional status” (RT @CaulfieldTim)

 

10 – Surprising And Sobering: 7 Facts About Global Health – NPR (free)

 

Tue, Apr 11 – 10 Medical Stories of The Day!

11Apr
2017

 

1 – Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study – BMC Medicine (free) (RT @atscommunity)

Cardioselective beta-blockers, mostly atenolol and bisoprolol in this cohort, were not associated with increased risk of moderate or severe asthma exacerbations. In contrast, non-selective beta-blockers, mostly sotalol and carvedilol in this cohort, were associated with increased risk.

 

2 – Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

“Labs performing these tests are reporting perfectly normal levels of vitamin D — 20 to 30 nanograms per milliliter of blood — as “insufficient.” As a consequence, millions of healthy people think they have a deficiency”

Note: Some organizations still think appropriate levels would be above 30 nanograms per milliliter of blood, more details in the text.

 

3 – Updated Fact Sheet: Lymphatic filariasis – World Health Organization (free) (RT @AbraarKaran)

See also: The Unexpected Cause Of This Awful Disease Lay Right Underfoot – NPR Health News (free) AND WHO’s Work on Neglected Tropical Diseases (free)

 

4 – Body-Weight Fluctuations and Outcomes in Coronary Disease – New England Journal of Medicine (link to abstract – $ required for full-text)

Source: Weight Fluctuation Tied to Mortality in CAD Population – MedPage Today (free registration required)

 

5 – Emergencies in Hematology and Oncology – Mayo Clinic Proceedings (free)

Comprehensive review covering the most common oncological emergencies.

 

6 – Pharmacological treatment optimization for stable chronic obstructive pulmonary disease. Proposals from the Société de Pneumologie de Langue Française (free)

 

7 – Risk of pneumonia associated with incident benzodiazepine use among community-dwelling adults with Alzheimer disease – CMAJ (free)

Source: Benzodiazepines Tied to Higher Pneumonia Risk in Patients with Alzheimer’s – Physician’s First Watch (free)

 

8 – Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials – The Lancet (link to abstract – $ required for full-text) (RT @AnilMakam “Lower achieved blood pressure in high risk patients for cardiovascular disease do WORSE” see Tweets)

In high-risk patients, patients who achieved a systolic blood pressure < 120 mmHg or a diastolic blood pressure < 70 mmHg had HIGHER risk of complications. “These data suggest that the lowest blood pressure possible is not necessarily the optimal target for high-risk patients”

 

9 – Richard Lehman’s weekly review of medical journals – The BMJ Blogs (free)

 

10 – Toward Responsible Human Genome Editing – JAMA (free)

 

Mon, Apr 10 – Top 10 Medical News Stories

10Apr
2017

 

Links = Interest ≠ Endorsement

 

1 – Hypertension Canada’s 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults (free)

 

2 – Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients – New England Journal of Medicine (link to abstract – $ required for full text)

Quick Take Video Summary: SURTAVI Study: TAVR versus Open Surgery (free)

See this and other highlights from the American College of Cardiology’s 66th Annual Scientific Session (some articles are no longer free)

This innovative technology seems to be useful for patients with aortic stenosis at high risk for surgery. In this new study, it was noninferior to surgery at 2 years of follow-up in old patients (averaged nearly 80 years) at intermediate risk. Longer follow up data will be important to see if it is a suitable alternative for younger patients.

 

3 – The cross-cutting contribution of the end of neglected tropical diseases to the sustainable development goals – Infectious Diseases of Poverty (free) (RT @ghn_news see Tweet)

Related commentary from the author: Impact beyond the neglected (free)

See also: United Nations – Sustainable Development Goals

This review examines how the interventions being used against neglected tropical diseases are contributing to achieving the United Nation’s Sustainable Development Goals.

 

4 – The World Health Organization Adult Attention-Deficit/Hyperactivity Disorder Self-Report Screening Scale for DSM-5 – JAMA Psychiatry (free)

Invited commentary: Good News for Screening for Adult Attention-Deficit/Hyperactivity Disorder – JAMA Psychiatry (free)

See also: Do You Zone Out? Procrastinate? Might Be Adult ADHD – NPR Health News (free)

Others disagree… call it “disease mongering”, “overdiagnosis”. For example, Prof Allen Francis, author of Saving Normal: An Insider’s Revolt against Out-of-Control Psychiatric Diagnosis, DSM-5, Big Pharma, and the Medicalization of Ordinary Life, wrote some remarks about the study, see Tweet 1, Tweet 2 and Tweet 3

See also: The Selling of Attention Deficit Disorder – The New York Times (10 articles per month are free)

 

5 – F.D.A. Will Allow 23andMe to Sell Genetic Tests for Disease Risk to Consumers – The New York Times (10 articles per month are free)

See also: Before you send your spit to 23andMe, what you need to know – STAT News (free) AND 23andMe given green light to sell DNA tests for 10 diseases – Nature News (free) AND 23andMe Rides Again: FDA Clears Genetic Tests To Predict Disease Risk – Forbes (free) AND Too Much Information? FDA Clears 23AndMe to Sell Home Genetic Tests for Alzheimer’s and Parkinson’s – Scientific American (free)

“The controversial step will significantly expand direct-to-consumer testing – but what if the news is bad?” (from Scientific American above)

 

6 – TV. How much is too much for our kids? – World Economic Forum (free)

Original Article Abstract ($ required for full-text): Family Socioeconomic Status Moderates Associations Between Television Viewing and School Readiness Skills – Journal of developmental and behavioral pediatrics

See also: Media and Young Minds – Recommendations from The American Academy of Pediatrics (free) AND Pediatricians relax guidelines on screen time for kids to give more flexibility – STAT News (free)

 

7 – No TV during meals may lower obesity risk – Medical News Today (free)

Original article abstract ($ required for full-text): Television, Home-Cooked Meals, and Family Meal Frequency: Associations with Adult Obesity – Journal of the Academy of Nutrition and Dietetics

Related article: Screen time is associated with adiposity and insulin resistance in children – Archives of Diseases in Childhood (free) AND Screentime linked to greater diabetes risk among children – The Guardian (free)

The first study in adults and the second study in children suggest there might be a link between screen time and weight gain or adiposity.

 

8 – Here’s why one tech investor thinks some doctors will be ‘obsolete’ in five years – CNBC (free) (RT @CMichaelGibson)

According to this point of view, radiologists will be the first ones that are affected by Artificial Intelligence. As we can see below, other specialists that work by interpreting medical images may follow, like dermatologists, ophthalmologists and pathologists.

See also: If You Look at X-Rays or Moles for a Living, AI Is Coming for Your Job – Wired (free) AND Adapting to Artificial Intelligence: Radiologists and Pathologists as Information Specialists – JAMA Viewpoint (free – and legal – PDF found with Unpaywall) AND Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs – JAMA Internal Medicine (link to abstract – $ required for full-text) AND Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features – Nature (free) see commentary in Computers trounce pathologists in predicting lung cancer type, severity, researchers find – Science News (free)

 

9 – When Globalization Brings Brain-Invading Worms – The Atlantic (free) (RT @PreetiNMalani and @AdrienneLaF)

Infectious diseases are spreading faster and emerging quicker due to globalization.

 

10 – Seniors are given so many drugs, it’s madness – The Globe and Mail (free) (RT @RasoiniR)

“While most prescribing is well-intentioned, it’s also unco-ordinated; there is a tendency to overmedicate and leave people on drugs for too long”.

 

Fri, Apr 7 – 10 Medical Stories of The Day!

7Apr
2017

 

1 – Smoking prevalence and attributable disease burden in 195 countries and territories, 1990–2015: a systematic analysis from the Global Burden of Disease Study 2015 – The Lancet (free)

Related commentary: Death, disease, and tobacco (free)

Explore data visualizations by The Institute for Health Metrics and Evaluation (IHME) (free)

See also: Smoking causes one in ten deaths globally, major new study reveals – The Guardian (free)

See also: Other articles from The Global Burden of Diseases Study (free)

 

2 – Benefits of Endovascular Treatment for Stroke Last at Least 2 Years – Physician’s First Watch (free)

Original article abstract ($ required for full-text): Two-Year Outcome after Endovascular Treatment for Acute Ischemic Stroke – New England Journal of Medicine

 

3 – Association Between Antipsychotic Agents and Risk of Acute Respiratory Failure in Patients With Chronic Obstructive Pulmonary Disease – JAMA Psychiatry (Link to abstract – $ required for full-text) (RT @atscommunity)

See also: Antipsychotics Tied to Respiratory Failure in At-Risk Patients – Medscape (free registration required) AND Antipsychotics May Boost Respiratory Failure Risk in COPD – MedPage Today (free registration required)

 

4 – Social rank: a risk factor whose time has come? – The Lancet (free)

“Inequality kills – and there are many things we can do about it, but don’t” (RT @mellojonny see Tweet)

“Medical treatment has less influence on lifespan & health outcomes than the quality of social services & primary prevention programs” (RT @AllenFrancesMD see Tweet)

This interesting commentary provides a panel with evidence-based strategies to minimize the impact of social hierarchy on health.

 

5 – Now free: citation data from 14 million papers, and more might come – Science (free) (RT @robertkiley see Tweet) AND Initiative aims to break science’s citation paywall – Nature Breaking News (free) AND Global Coalition Pushes for Unrestricted Sharing of Scholarly Citation Data – Creative Commons (free) AND Initiative for Open Citations – I4OC (free)

Open Science, Open Access and Open Data gaining momentum.

 

6 – A prescription for the future: How hospitals could be rebuilt, better than before – The Economist (free) (RT @EricTopol)

“Technology could revolutionize the way they work”.

 

7 – Are Virtual Doctor Visits Really Cost-Effective? Not So Much, Study Says – Kaiser Health News (free)

“Perhaps telehealth visits don’t save money after all. Increased convenience can increase utilization” (RT @drval)

 

8 – Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE) – The BMJ (free)

Source: With same training, insulin pumps no better than injections – Reuters Health News (free) (RT @CMichaelGibson)

 

9 – Singapore Ministry of Health Clinical Practice Guidelines: Lipids (free PDF)

 

10 – Nearly a third of tests and treatments are unnecessary – CMAJ News (free) (RT @ChooseWiselyCA)

Press release: Canadians have more than 1 million potentially unnecessary medical tests and treatments every year – Canadian Institute for Health Information (free) 

See report: Unnecessary Care in Canada (free PDF)

Growing problem in many countries, making resources less available for treatments and conditions that matter.

 

Thu, Apr 6 – 10 Medical Stories of The Day!

6Apr
2017

 

1 – The first issue of the Lancet Planetary Health is out (#OpenAccess)

Editorial: Welcome to The Lancet Planetary Health

 

2 – Unpaywall finds free versions of paywalled papers – Nature (free) (RT @dannykay68)

See also: Unlocking paywalled research papers: Two big steps forward, two steps back, by James C Coyne – Coyne of the Realm (RT @hildabast)

Apparently, it successfully finds an open-access version (completely legal) of a paper around 30% of the time. We have tried and it worked for some of the articles we’ve tested. See it for yourself.

 

3 – Long-term use of antibiotics and risk of colorectal adenoma – Gut (free)

Sources: Antibiotics overuse could increase bowel cancer risk, study finds – The Guardian (free) (RT @Onisillos) AND Long-Term Use of Antibiotics Associated with Later-Life Colorectal Adenomas – Physician’s First Watch (free)

 

4 – Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis – Pediatrics (free)

See also: Study: Pertussis shot in pregnant moms protects newborns – CIDRAP (free)

Source: Global Health NOW Newsletter

 

5 – Inhaled Corticosteroids May Raise Women’s Risk of the Metabolic Syndrome – NewsWise (free)

See also: Inhaled Corticosteroid Use May Up Metabolic Syndrome Risk – MPR (free)

This study was presented at #ENDO2017 and hasn’t been published yet.

 

6 – National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes (free)

 

7 – Low-dose aspirin can reduce risk of death from cancer, research says – CNN (free)

Not so fast: CNN claims aspirin can reduce cancer death risk, falling into observational study trap – HealthNewsReviews (free)

See also: Final Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer – U.S. Preventive Services Task Force (free)

 

8 – Cancer patients have 55% greater risk of suicide, study finds – The Guardian (free) (RT @ghn_news)

 

9 – Antibiotic-Resistant ‘Superbugs’ Are Here – Council on Foreign Relations (free)

See also: Tackling Drug-Resistant Infections Globally: final report and recommendations (free)

Source: Global Health NOW Newsletter

 

10 – Managing supplies of vaccines is a huge problem – The Economist (free) (RT @glassmanamanda)

See also: Building Next Generation Immunization Supply Chains – Vaccine Supplement (free) AND Global Immunization Impact Constrained by Outdated Vaccine Delivery Systems, Researchers Say – World Health Organization (free)

 

Wed, Apr 5 – 10 Medical Stories of The Day!

5Apr
2017

 

1 – Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine (free)

Source: Levothyroxine Shows No Benefit in Older Adults with Subclinical Hypothyroidism – Physician’s First Watch (free)

 

2 – Cardiometabolic Abnormalities Among Normal-Weight Persons From Five Racial/Ethnic Groups in the United States: A Cross-sectional Analysis of Two Cohort Studies – Annals of Internal Medicine (link to abstract – $ required for full-text)

Sources: Certain Racial/Ethnic Groups More Likely to Have Cardiometabolic Abnormalities at Normal Weight – Physician’s First Watch (free) AND Cardiovascular Risk High Among Some Normal Weight Minorities – Medscape (free registration required)

Compared with whites, all racial/ethnic minority groups had higher prevalence of metabolic abnormalities, with a high prevalence even in persons with normal weight. The prevalence of metabolic abnormalities in whites with a BMI of 25 kg/m2 corresponded to the prevalence in BMI values of 22.9 kg/m2 in African Americans, 21.5 kg/m2 in Hispanics, 20.9 kg/m2 in Chinese Americans, and 19.6 kg/m2 in South Asians.

 

3 – The wound/burn guidelines – Japanese Dermatological Association (all guidelines are free)

Wounds in general / Guidelines for the diagnosis and treatment for pressure ulcers / Guidelines for the diagnosis and treatment for diabetic ulcer/gangrene / Guidelines for the management of skin ulcers associated with connective tissue disease/vasculitis / Guidelines for the management of lower leg ulcers/varicose veins / Guidelines for the management of burns

 

4 – Management of the Diseases of Mesenteric Arteries and Veins: Clinical Practice Guidelines of the European Society of Vascular Surgery (free)

 

5 – CUA guideline on the management of cystic renal lesions – Canadian Urological Association Journal (free)

 

6 – Choosing Wisely initiative was launched 5 years ago, and now has over 490 recommendations from 18 countries (all resources are free)

Lists from other countries: Choosing Wisely UK / Choosing Wisely Australia / Choosing Wisely Canada

The Choosing Wisely is a leading effort to encourage conversations aimed at reducing unnecessary tests and treatments to improve value in healthcare.

 

7 – Attention-Deficit/Hyperactivity Disorder – Deutsches Ärzteblatt international (free)

 

8 – Seven reasons we’re at more risk than ever of a global pandemic – CNN (free) (RT @AthaliaChristie)

 

9 – One in 10 Pregnant Women With Zika in U.S. Have Babies With Birth Defects – The New York Times (10 articles a month are free)

See also: 51 Babies Born With Zika-Related Birth Defects In The U.S. Last Year – NPR (free) AND Just released CDC report (free)

 

10 – Prognosis of undiagnosed chest pain: linked electronic health record cohort study – The BMJ (free)

See also: Patients with Undiagnosed Chest Pain Still at Cardiovascular Risk – Physician’s First Watch (free)

“Chest pain rarely harmless. Even if undiagnosed 6 months after first presentation linked to increased cardiac events.” (RT @pascalmeier74)

 

Tue, Apr 4 – Top 10 Medical News Stories

4Apr
2017

 

1 – Child and Adolescent Health From 1990 to 2015: Findings from the Global Burden of Diseases, Injuries, and Risk Factors 2015 Study – JAMA Pediatrics (free)

Editorial: Importance of Innovations in Neonatal and Adolescent Health in Reaching the Sustainable Development Goals by 2030 (free)

Source: Child Deaths Drop From 14.2 Million In 1990 To 7.3 Million In 2015 – NPR Goats and Soda (free)

 

2 – Just Started! Free Online Course: Essentials of Global Health – Yale University and Coursera

 

3 – Free Online Course, Starts April 10. To Screen or not to Screen? Methods and health policies through case studies – University of Geneva and Coursera

 

4 – Free Online Course, Starts April 17. An Introduction to Population Health – University of Manchester and Coursera

 

5 – ACR Appropriateness Criteria Adds Topics, Covers More Clinical Variants Than Ever Before (free)

Browse Appropriateness Criteria Topics (free)

Source: Newswise

This comprehensive guide from American College of Radiology (ACR) covers 230 topics with more than 1,100 clinical indications and has just been updated. It is a very useful resource for doctors in all specialties to guide which exam is most appropriate in each clinical situation.

 

6 – Management of Inpatient Hyperglycemia and Diabetes in Older Adults – Diabetes Care (free)

Source: Management of Hyperglycemia in Elderly, Hospitalized Adults – PracticeUpdates (free registration required)

 

7 – The association between insomnia symptoms and risk of cardio-cerebral vascular events: A meta-analysis of prospective cohort studies – European Journal of Preventive Cardiology (free)

Source: Insomnia associated with increased risk of heart attack and stroke – EurekAlert (free) (RT @CaulfieldTim)

 

8 – You Should Appreciate Germs – Gates Notes (free)

 

9 – Eosinophilia – Primary Care: Clinics in Office Practice (free)

 

10 – It’s not just you: science papers are getting harder to read – Nature (free)

More commentaries on academic writing and the importance of making research understandable to all: ‘It’s time to make sure research is understandable to all’ – The Telegraph (free) AND Scientific language is becoming more informal – Nature (free)

 “Here we show that in mice DND1 binds a UU(A/U) trinucleotide motif predominantly in the 3′ untranslated regions of mRNA, and destabilizes target mRNAs through direct recruitment of the CCR4-NOT deadenylase complex”

 

Mon, Apr 3 – Top 10 Medical News Stories

3Apr
2017

 

1 – Building Next Generation Immunization Supply Chains – Vaccine Supplement (free)

News release: Global Immunization Impact Constrained by Outdated Vaccine Delivery Systems, Researchers Say – World Health Organization (free)

See also: Battling Infectious Diseases in the 20th Century: The Impact of Vaccines (free – classic 2015 page with interesting infographics) (RT @stefaniei)

This 29 open access articles are part of a special supplement published in Vaccine to address the challenges of Immunization Supply Chains.

 

2 – Return on investment of public health interventions: a systematic review – Journal of Epidemiology and Public Health (free)

Source: BMJ News ($)

“For every £1 invested in public health, £14 will subsequently be returned to the wider health and social care economy”. Based on the findings, the authors suggest that cuts to public health services are short sighted and represent a false economy, with substantial opportunity costs.

 

3 – Neuropathic pain in adults: pharmacological management in non-specialist settings – Updated NICE Guideline (free)

 

4 – The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) (RT @glassmanamanda and @BillGates)

 

5 – Effects of intensive glucose control on microvascular outcomes in patients with type 2 diabetes: a meta-analysis of individual participant data from randomised controlled trials – The Lancet Diabetes & Endocrinology (RT @EricTopol see Tweet with interest discussion) (link to abstract – $ required for full-text)

Contradicting the analysis above, a recent report found no significant impact of tight glycemic control on the risk of dialysis / transplantation / renal death, blindness, or neuropathy: Glycemic Control for Patients With Type 2 Diabetes Mellitus: Our Evolving Faith in the Face of Evidence – Circulation (free)

Benefits of intensive glucose control on microvascular outcomes in patients with type 2 diabetes remains controversial.

 

6 – Cognitive Dysfunction in Older Adults With Diabetes: What a Clinician Needs to Know – Diabetes Care (free)

Source: Management of Older Adults With Diabetes and Cognitive Dysfunction – PracticeUpdate (free registration required)

“Recommendations include the need for simplified medication regimens, avoidance of glucose-lowering drugs with a high risk of hypoglycemia, periodic reassessment of glycemic goals, and repeated education of the patient and caregiver” (from PracticeUpdate commentary above)

 

7 – Functional Hypothalamic Amenorrhea: An Endocrine Society Clinical Practice Guideline (free PDF)

Source: Endocrine Society Issues Hypothalamic Amenorrhea Guideline – Medscape (free registration required)

 

8 – Addition of anti-leukotriene agents to inhaled corticosteroids for adults and adolescents with persistent asthma – Cochrane Database of Systematic Reviews (link to summary – $ required for full-text)

Source: EvidenceAlerts

In patients with asthma not controlled with daily low-dose inhaled corticosteroids, adding anti-leukotriene agents reduced by half the number of patients with asthma exacerbations requiring an oral corticosteroid and improved lung function and asthma control.

 

9 – Anemia and blood transfusion in the critically ill patient with cardiovascular disease – Critical Care (free)

 

10 – Corticosteroids in septic shock: a systematic review and network meta-analysis – Critical Care (free)

 

Fri, Mar 31 – Top 10 Medical News Stories

31Mar
2017

 

1 – Press release: “Depression: let’s talk” says WHO, as depression tops list of causes of ill health – World Health Organization (free)

See also: Depression: let’s talk – WHO campaign (free) AND Depression updated factsheet (free) AND Depression and Other Common Mental Disorders: Global Health Estimates (free)

Depression is now the leading cause of ill health and disability worldwide, according to The World Health Organization.

 

2 – Spondyloarthritis in Over 16s: Diagnosis and Management – NICE Guideline (free)

See also: 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis (free)

 

3 – Mental health of adults in contact with the criminal justice system – NICE Guideline (free)

News release: Checks needed every year for people with a mental health problem in the criminal justice system, says NICE (free)

 

4 – Zika Virus Infection and Associated Neurologic Disorders in Brazil – New England Journal of Medicine (free)

See also: Why Were There Fewer Microcephaly Cases from Zika Last Year? – STAT (free)

Source: Global Health NOW Newsletter

In Brazil, there were many fewer cases of microcephaly than expected in 2016. The researchers are trying to find an explanation.

 

5 – New Lists from Choosing Wisely Canada – List of Items Physicians and Patients Should Question (all resources are free)

Critical Care / Pediatric neurosurgery / Sport and exercise medicine / Nursing / Long term care / Medical microbiology

Lists from other countries: Choosing Wisely UK / Choosing Wisely Australia / Choosing Wisely U.S.

The Choosing Wisely initiative aims to reduce unnecessary tests, treatments and procedures to reduce harm and promote value in healthcare.

 

6 – Impact of total knee replacement practice: cost effectiveness analysis of data from the Osteoarthritis Initiative – The BMJ (free)

See also: Knee Replacement Should Be Reserved for More Severe Osteoarthritis, Study Suggests – Physician’s First Watch (free)

Total knee replacement for patients with osteoarthritis had minimal effects on quality of life in this study. Severely affected patients seem to benefit the most from the procedure.

 

7 – Exposure to any antenatal corticosteroids and outcomes in preterm infants by gestational age: prospective cohort study – The BMJ (free)

Editorial: Antenatal corticosteroids for women at risk of preterm delivery (free)

See also: Antenatal Steroids Benefit Very Premature Infants Most – Medscape (free registration required)

“This study found that among infants born from 23 to 34 weeks’ gestation, antenatal exposure to corticosteroids compared with no exposure was associated with lower mortality and morbidity at most gestations”.

 

8 – History of Periodontitis Diagnosis and Edentulism as Predictors of Cardiovascular Disease, Stroke, and Mortality in Postmenopausal Women – Journal of the American Heart Association (free) (RT @kamleshkhunti)

Press release: Gum disease, tooth loss may increase postmenopausal women’s risk of death – American Heart Association Rapid Access Journal Report (free)

History of periodontal disease was associated with a 12 percent higher risk of death from any cause and loss of all natural teeth was associated with a 17 percent higher risk of death from any cause.

 

9 – The seven deadly sins of statistical misinterpretation, and how to avoid them – The Conversation (free) (RT @Sab_Ra)

 

10- Approach to preventive care in the elderly – Canadian Family Physician (free)

 

Thu, Mar 30 – Top 10 Medical News Stories

30Mar
2017

 

1 – 100 Objects That Shaped Public Health: From the Obscure to the Everyday, These Objects Tell the Story – Global Health NOW (free)

Very interesting compilation with 100 objects that have made their mark on public health (for better or worse).

 

2 – Press release: WHO Launches Global Effort to Halve Medication-Related Errors in 5 Years – World Health Organization (free)

See also: WHO’s work on patient safety (free) AND WHO Global Patient Safety Challenge on Medication Safety (free) AND WHO Educational materials for medication safety (free)

 

3 – Non–Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation and Valvular Heart Disease – Journal of the American College of Cardiology (free)

Source: SciCombinator

Except for patients with moderate/severe mitral stenosis or mechanical heart valves, who were excluded in most trials, high-dose NOACs was as effective and safe for patients with valvular heart disease as for patients without valvular disorders.

 

4 – Clinical Trials of Therapeutics for the Prevention of Congenital Zika Virus Disease: Challenges and Potential Solutions – Annals of Internal Medicine (free)

 

5 – Persistent erectile dysfunction in men exposed to the 5α-reductase inhibitors, finasteride, or dutasteride – PeerJ (free)

Source: SciCombinator

Observational data suggests there might be a link.

 

6 – Prevention of everolimus-related stomatitis in women with hormone receptor-positive, HER2-negative metastatic breast cancer using dexamethasone mouthwash (SWISH): a single-arm, phase 2 trial – The Lancet Oncology (link to abstract – $ required for full-text)

See also: SWISH Four Times a Day to Keep Oral Mucositis Away – Medscape (free registration required)

This simple and inexpensive treatment resulted in a more than ten-times reduction in the incidence of grade 2 or higher stomatitis.

 

7 – A National Strategy for the Elimination of Hepatitis B and C: Phase Two Report – National Academies of Sciences, Engineering, and Medicine (free)

Press release: U.S. Could Be Rid of Hepatitis B and C as Public Health Problems, Preventing Nearly 90,000 Deaths by 2030, With Better Attention to Prevention, Screening, Treatment, and Creative Financing for Medicines (free)

See also: Phase One Report (free)

U.S. Strategy for the Elimination of Hepatitis B and C.

 

8 – Five ways consortia can catalyse open science – Nature (free)

 

9 – Exposing peer review – Research Information (free) (RT @Sab_Ra)

See also other recent commentaries on the peer review system

 

10 – Ten Steps to Producing a Well-Written Evidence-Based Health Care Dissertation – Centre for Evidence-Based Medicine, University of Oxford (free)

 

Wed, Mar 29 – Top 10 Medical News Stories

29Mar
2017

 

1 – Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

See also: ACP: Stop Saddling Docs With Administrative Tasks – MedPage Today (free registration required)

“It’s time for all those involved in the healthcare industry to reevaluate and reduce the administrative task burden placed on clinicians” (from MedPage commentary above).

 

2 – Effective Prevention and Treatment of Substance Use Disorders – An American College of Physicians Position Paper (free)

See also: Treat Substance Abuse as Chronic Condition, ACP Says – Medscape (free registration required) AND Physicians call for drug abuse to be treated as ‘chronic disease’ – ABCNews (free)

 

3 – I have cancer. This comic shows how much pressure I feel to be a hero – VOX (free)

Source: STAT Newsletter

Interesting read…

 

4 – EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs – Annals of Rheumatic Diseases (free)

See also: EULAR Releases New RA Tx Recommendations: Focus is on conventional agents, biologics, and targeted synthetic drugs – MedPage Today (free registration required)

Source: EvidenceAlerts Newsletter

 

5 – Validating the HERDOO2 rule to guide treatment duration for women with unprovoked venous thrombosis: multinational prospective cohort management study – The BMJ (free)

Source: Richard Lehman’s weekly review

HERDOO2 rule stands for Hyperpigmentation, Edema, or Redness in either leg; D-dimer level ≥250 μg/L; Obesity with body mass index ≥30; or Older age, ≥65 years. The authors concluded that women with a first unprovoked VTE event and none or one of the HERDOO2 criteria have a low risk (3.0% per patient year) of recurrent VTE and can safely discontinue anticoagulants after completing short term treatment.

 

6 – Comparison of Antibiotic Therapy and Appendectomy for Acute Uncomplicated Appendicitis in Children: A Meta-analysis – JAMA Pediatrics (free)

Editorial: Medical Treatment of Pediatric Appendicitis: Are We There Yet? (free)

See also a recent meta-analysis and related commentaries on the same subject (free)

Nonoperative treatment was successful in 90% of cases. Subgroup analysis indicated an increased risk for initial fails and recurrent appendicitis in those with appendicolith.

 

7 – Screening for Celiac Disease: US Preventive Services Task Force Recommendation Statement (free)

Editorial 1: The US Preventive Services Task Force Recommendation on Screening for Asymptomatic Celiac Disease: A Dearth of Evidence (free)

Editorial 2: Celiac Disease and Nonceliac Gluten or Wheat Sensitivity: The Risks and Benefits of Diagnosis (free)

“Some sanity about screening for asymptomatic celiac disease in the gluten-free diet “epidemic” era” (RT @EricTopol see Tweet)

 

8 – Value-Based Purchasing: Time for Reboot or Time to Move On? by Ashish K. Jha, MD – The JAMA Forum (free)

Pay-for-performance (P4P) as a policy tool does not seem to be improving health care quality or lowering costs.

 

9 – The year in cardiology 2016: peripheral circulation – European Heart Journal (free)

 

10 – Regression to the mean, or why perfection rarely lasts – The Conversation (free) (RT @PaulGlasziou)

“Regression to the mean, and its importance in healthcare decisions” (RT @Tammy_Hoffmann see Tweet)

 

Tue, Mar 28 – Top 10 Medical News Stories

28Mar
2017

 

1 – A framework for malaria elimination – World Health Organization (free) (RT @Onisillos)

News release: WHO releases new guidance on malaria elimination (free)

“Updated 2017 framework gives guidance, tools, activities and strategies to achieve malaria elimination, 10 years on” (RT @MalariaAtlas)

 

2 – Implementation and Evaluation of a Large-Scale Teleretinal Diabetic Retinopathy Screening Program in the Los Angeles County Department of Health Services – JAMA Internal Medicine (free) (RT @PreetiNMalani)

Editorial: Seeing the Effect of Health Care Delivery Innovation in the Safety Net (free)

A large-scale telemedicine diabetic retinopathy screening program increased overall rates of screening by 16.3%, and wait times for screening were reduced by 89.2%.

 

3 – Association of Gastric Acid Suppression with Recurrent Clostridium difficile Infection: A Systematic Review and Meta-analysis (link to abstract – $ required for full-text)

“Another study that suggests gastric acid suppression may increase risk of recurrent Clostridium difficile” (RT @PreetiNMalani)

 

4 – The Comics Revealing Medical School’s Hidden Flaws and Hard Lessons – The Atlantic (free)

Source: Global Health Now Newsletter

Very interesting read…

 

5 – A.I. VERSUS M.D – What happens when diagnosis is automated? – The New Yorker (free) (RT @EricTopol)

“In some trials, “deep learning” systems have outperformed human experts.”

 

6 – Richard Lehman’s weekly review of medical journals, 27 March 2017 – The BMJ Blogs (free)

 

7 – Just Started: Leading Healthcare Quality and Safety – Free Online Course from The George Washington University and Coursera (free)

 

8 – Management of Breech Presentation: Green-top Guideline – British Journal of Obstetrics and Gynaecology (free)

 

9 – Enhanced recovery after surgery: Current research insights and future direction – World Journal of Gastrointestinal Surgery (free)

 

10 – Diagnosis of chronic thromboembolic pulmonary hypertension – European Respiratory Review (free)

 

Mon, Mar 27 – Top 10 Medical News Stories

27Mar
2017

 

1 – Gates Foundation announces open-access publishing venture – Nature News (free)

See also: Open science: The findings of medical research are disseminated too slowly – That is about to change – The Economist (free) AND Cooming Soom: Gates Open Research – Bill and Melinda Gates foundation (free) AND Gates Foundation joins shift towards open access platforms – Times Higher Education (free) AND Gates Open Research: the journey continues – F1000 Blog (free)

Another victory for open science.

 

2 – Going Under the Knife, With Eyes and Ears Wide Open – New York Times (free access to 10 articles per month)

“More and more surgeries are being performed with the patient awake and looking on, for financial and medical reasons”.

 

3 – Telehealth Doctor Visits May Be Handy, But Aren’t Cheaper Overall – NPR Health News (free)

Link to original article abstract ($ required for full-text): Direct-To-Consumer Telehealth May Increase Access to Care But Does Not Decrease Spending – Health Affairs

Costs have increased in this study because 88 percent of telehealth visits represented people who would not have gone to a doctor otherwise.

 

4 – ESPEN guideline: Clinical nutrition in surgery – Clinical Nutrition (free)

Source: Critical Care Reviews Newsletter

 

5 – HER2 Testing and Clinical Decision Making in Gastroesophageal Adenocarcinoma: Guideline From the College of American Pathologists, American Society for Clinical Pathology, and the American Society of Clinical Oncology (free)

Source: EvidenceAlerts (free registration required)

 

6 – Adverse Effects of Prostate Cancer Treatments Vary – MedPage Today (free registration required)

Study 1 – Link to abstract ($ required for full-text): Association Between Radiation Therapy, Surgery, or Observation for Localized Prostate Cancer and Patient-Reported Outcomes After 3 Years – JAMA

Study 2 – Link to abstract ($ required for full-text): Association Between Choice of Radical Prostatectomy, External Beam Radiotherapy, Brachytherapy, or Active Surveillance and Patient-Reported Quality of Life Among Men With Localized Prostate Cancer – JAMA

 

7 – Revised Framingham Stroke Risk Profile to Reflect Temporal Trends – Circulation (free)

“A revised Framingham Stroke Risk Profile more accurate at predicting contemporary stroke risk”.

“Instant classic paper on stroke risk prediction?! Will patients be interested in this?” (RT @MaryCushmanMD)

 

8 – Association between clinically recorded alcohol consumption and initial presentation of 12 cardiovascular diseases: population based cohort study using linked health records – The BMJ (free)

Editorial: Alcohol and cardiovascular disease (free)

See also: Alcohol and the Heart: Moderation Still Best – Generally higher risks seen with no or heavy drinking – MedPage Today (free registration required)

 

9 – Maternal multiple micronutrient supplementation and other biomedical and socioenvironmental influences on children’s cognition at age 9–12 years in Indonesia: follow-up of the SUMMIT randomised trial – The Lancet Global Health (free)

Related commentary: Prenatal nutrition, socioenvironmental conditions, and child development (free)

“Maternal MMN had long-term benefits for child cognitive development at 9–12 years of age, thereby supporting its role in early childhood development, and policy change toward MMN”. The related commentary above does not seem to agree with this statement from the authors, stating that the new evidence does not provide enough weight for a policy change from prenatal iron and folate to MMN supplementation.

 

10 – #WorldTBDay (24 March 2017) – New Commentaries (see previous commentaries and resources)

New estimate suggests a quarter of the world’s population has latent tuberculosis – The Conversation (free) AND Report warns of rise in drug-resistant tuberculosis – CIDRAP (free) AND Latest transmission patterns for drug resistant TB pose a new challenge – The Conversation (free)

 

Fri, Mar 24 – Top 10 Medical News Stories

24Mar
2017

 

#WorldTBDay, 24 March 2017 – Highlights from Today’s Campaigns and Resources

 

1 – #WorldTBDay – World Health Organization Campaign (free)

See also: WHO’s work on TB (free)

 

2 – #WorldTBDay – Ethics guidance for the implementation of the End TB strategy 2017 – World Health Organization (free)

News Release: WHO issues ethics guidance to protect rights of TB patients (free)

 

3 – #WorldTBDay – The End TB Strategy – World Health Organization (free)

See also: Implementing the end TB strategy: the essentials (free)

 

4 – #WorldTBDay – Global tuberculosis report 2016 – World Health Organization (free)

News release: WHO report warns global actions and investments to end tuberculosis epidemic are falling far short (free)

 

5 #WorldTBDay – WHO treatment guidelines for drug-resistant tuberculosis (2016 update) – World Health Organization (free)

See also: WHO resources on drug-resistant tuberculosis (free)

 

6 – #WorldTBDay – Centers for Disease Control and Prevention (CDC) Campaign (free)

 

7 – #WorldTBDay – The epidemiology, pathogenesis, transmission, diagnosis, and management of multidrug-resistant, extensively drug-resistant, and incurable tuberculosis – The Lancet Respiratory Medicine (free registration required)

See also: Decades of TB progress threatened by drug-resistant bacteria, warn experts – The Guardian (free)

“Rise of multi-drug resistant strains of tuberculosis could derail global efforts to eradicate the disease, according to a new report”

 

8 – #WorldTBDay – Open Access Special collection from Elsevier Journals  (free)

 

9 – #WorldTBDay – Clinical management of adults and children with multidrug-resistant and extensively drug-resistant tuberculosis – Clinical Microbiology and Infection (free)

 

10 – #WorldTBDay – Preventing the spread of multidrug-resistant tuberculosis and protecting contacts of infectious cases – Clinical Microbiology and Infection (free)

 

Thu, Mar 23 – Top 10 Medical News Stories

23Mar
2017

 

1 – Efficacy of a Low-Cost, Heat-Stable Oral Rotavirus Vaccine in Niger – New England Journal of Medicine (free)

Editorial: Rotavirus Vaccines – A New Hope (free)

Quick Take Video Summary: Efficacy of Heat-Stable Oral Rotavirus Vaccine (free)

 

2 – Trial of Pregabalin for Acute and Chronic Sciatica – New England Journal of Medicine (link to abstract – $ required for full-text)

Pregabalin did not reduce pain and was associated with higher incidence of adverse events.

 

3 – #WorldWaterDay (22 March 2017): Guidelines for drinking-water quality 2017 – World Health Organization (free)

See also: Drinking Water Fact Sheet – World Health Organization (free) AND Water sanitation hygiene – WHO Programme (free) AND World Water Day 2017 – Centers for Disease Control and Prevention (CDC) (free)

 

4 – Selected articles from the Annual Update in Intensive Care and Emergency Medicine 2017 – Critical Care (free)

10 open access review articles selected from the Annual Update in Intensive Care and Emergency Medicine 2017.

 

5 – Mechanical ventilation in obese ICU patients: from intubation to extubation – Critical Care (free)

 

6 – Implementation of key demand-reduction measures of the WHO Framework Convention on Tobacco Control and change in smoking prevalence in 126 countries: an association study – The Lancet Public Health (free)

Related Commentary: Understanding the association between the WHO Framework Convention on Tobacco Control, adoption of tobacco control policies, and reduction in smoking prevalence (free)

“The authors deserve ample credit for reinforcing, with solid empirical evidence, the core message in the FCTC: tobacco control policy matters”

 

7 – Genetic assessment of age-associated Alzheimer disease risk: Development and validation of a polygenic hazard score – PLOS Medicine (free) (RT @EricTopol see Tweet)

See also: New Alzheimer’s test can predict age when disease will appear – The Guardian (free)

*Very interesting, but do we want to know?*

 

8 – PLOS Medicine special issue edited by Carol Brayne & Bruce Miller: Dementia Across the Lifespan and Around the Globe (free) (RT @tshakey)

 

9 – Prosthetic joint infection development of an evidence-based diagnostic algorithm – European Journal of Medical Research (free)

Comprehensive review with practical algorithm.

 

10 – Dairy consumption, systolic blood pressure, and risk of hypertension: Mendelian randomization study – The BMJ (free)

Contradicting evidence from previous observational studies, dairy consumption was not associated with lower blood pressure.

 

Wed, Mar 22 – Top 10 Medical News Stories

22Mar
2017

 

1 -Effect of Intensive vs Moderate Alveolar Recruitment Strategies Added to Lung-Protective Ventilation on Postoperative Pulmonary Complications: A Randomized Clinical Trial – JAMA (free)

Editorial: Optimizing the Settings on the Ventilator Settings: High PEEP for All? (free)

In patients with hypoxemia after cardiac surgery, a more intensive alveolar recruitment strategy applied postoperatively was associated with reduced severity of pulmonary complications.

 

2 – Association of Suicidality and Depression With 5α-Reductase Inhibitors – JAMA Internal Medicine (free)

Invited Commentary: The Risk of Suicidality and Depression From 5-α Reductase Inhibitors (free)

“5-alpha reductase inhibitors in older men are associated with increased risk of self-harm and depression”

 

3 – Sleep Apnea: Types, Mechanisms, and Clinical Cardiovascular Consequences – Journal of the American College of Cardiology (free)

Source: Medscape Week in Review Newsletter (free registration required)

 

4 – Early, Goal-Directed Therapy for Septic Shock – A Patient-Level Meta-Analysis – New England Journal of Medicine (free)

Contradicting earlier studies and guidelines, “Early, Goal-Directed Therapy” did not improve results in septic shock and was associated with higher hospitalization costs.

 

5 – Oral Direct-Acting Agent Therapy for Hepatitis C Virus Infection: A Systematic Review – Annals of Internal Medicine (free) (RT @greg_folkers)

See also: Hepatitis C drugs remain unaffordable in many countries, says WHO study – STAT News (free)

 

6 – The Power of Conferences in a Social-Media Age: A guide to using technology to make face-to-face gatherings even more valuable – The Wall Street Journal (a few articles per month are free)

This new trend is here to stay. In the past few days we could all follow #ACC17 very closely through twitter. The numbers of the meeting: 237,217,427 Impressions; 43,678 tweets; and 15,970 participants (RT @CMichaelGibson see Tweet)

 

7 – Can science rob snakes of their deadliest weapon? – STAT News (free)

“Snakebites claim so many more victims than such high-profile threats as Ebola and many other tropical diseases” (RT @ininteraction see Tweet)

 

8 – Intradiscal Steroid Injection of “Questionable” Benefit for Low Back Pain with Discopathy – Physician’s First Watch (free)

Original article abstract ($ required for full-text): Intradiscal Glucocorticoid Injection for Patients With Chronic Low Back Pain Associated With Active Discopathy: A Randomized Trial – Annals of Internal Medicine

 

9 – Just Started: Global Health at the Human-Animal-Ecosystem Interface – Free Online Course from the University of Geneva and Coursera

Watch teaser: https://youtu.be/rkiJTwBud2o

 

10 – Peer Into the Post-Apocalyptic Future of Antimicrobial Resistance – WIRED (free) (RT @PreetiNMalani)

See also: LinksMedicus Selection of news and education resources on #AntibioticResistance (Published Sep 21, 2016)

“if left unchecked, in the next 35 years antimicrobial resistance could kill 300,000,000 people worldwide and stunt global economic output by $100 trillion”

 

Tue, Mar 21 – Top 10 Medical News Stories

21Mar
2017

 

1 – Management of COPD exacerbations: a European Respiratory Society/American Thoracic Society guideline – European Respiratory Journal (free)

Source: Critical Care Reviews Newsletter

 

2 – Acute kidney disease and renal recovery: consensus report of the Acute Disease Quality Initiative (ADQI) 16 Workgroup – Nature Reviews Nephrology (free)

Source: Critical Care Reviews Newsletter

 

3 – Thoracic Ultrasound: What Non-radiologists Need to Know – Current Pulmonology Reports (free)

Source: Critical Care Reviews Newsletter

Comprehensive review with descriptive videos.

 

4 – Characteristics of Initial Prescription Episodes and Likelihood of Long-Term Opioid Use – Morbidity and Mortality Weekly Report (MMWR), CDC (free)

See also: The risk of a single 5-day opioid prescription, in one chart – VOX (free)

“One simple way to curb opioid overuse: prescribe them for 3 days or less” – dependency on opioids can develop quickly and the risk increases after 4-5 days.

 

5 – Patient Mortality During Unannounced Accreditation Surveys at US Hospitals – JAMA Internal Medicine (free)

Patients admitted to hospitals during Accreditation Surveys had significantly lower mortality than during nonsurvey weeks.

“To reduce hospital mortality, I guess we should have unannounced accreditation surveys every day” (RT @EricTopol – see Tweet).

 

6 – Heartbeat: Challenges in primary prevention of cardiovascular disease – Heart (free)

Editorial: Statins for primary prevention of cardiovascular disease (free)

See also: Lessons from the controversy over statins, By Fiona Godlee (BMJ Editor in Chief – letter in The Lancet questioning the evidence regarding statins for primary prevention of cardiovascular disease)

 

7 – News from ACC 2017: Rivaroxaban vs. Aspirin to Prevent Recurrent VTE / Evolocumab’s Clinical Outcomes / More… – Physician’s First Watch (free)

 

8 – Pop a Pill for Heartburn? Try Diet and Exercise Instead – The New York Times (free)

See also: When is proton pump inhibitor use appropriate? – BMC Medicine (free) AND Effective and safe proton pump inhibitor therapy in acid-related diseases – A position paper addressing benefits and potential harms of acid suppression – BMC Medicine (free) AND Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury – Kidney International (free)

 

9 – Richard Lehman’s weekly review of medical journals, 20 March 2017 – The BMJ Blogs (free)

 

10 – Association of Preceding Antithrombotic Treatment With Acute Ischemic Stroke Severity and In-Hospital Outcomes Among Patients With Atrial Fibrillation – JAMA Internal Medicine (link to abstract – $ required for full-text)

Source: Richard Lehman’s weekly review (free)

“In patients with acute ischemic stroke who had a known history of atrial fibrillation, 84% did not receive guideline-recommended therapeutic anticoagulation preceding the stroke”, showing the importance of adequate anticoagulation in this population.

 

Mon, Mar 20 – Top 10 Medical News Stories

20Mar
2017

 

#ACC17 – Highlights from the American College of Cardiology’s 66th Annual Scientific Session

 

1 – #ACC17 – PCI, Drugs Equally Beneficial for Treating Fully Blocked Arteries: Study shows percutaneous coronary intervention is not needed in all cases – Latest in Cardiology, American College of Cardiology (free)

See also: First Clinical Trial of CTO Procedures Fails to Deliver – Medscape (free registration required)

– Among patients with at least one coronary chronic total occlusion (CTO), percutaneous coronary intervention (PCI) added to optimal medical therapy did not improve outcomes.

– “DECISION-CTO is a strong RCT testing medical therapy to CTO procedures. No diff in outcomes and, crucially, no diff in angina. Wow” (RT @drjohnm – see tweet).

 

2 – #ACC17 – Evolocumab and Clinical Outcomes in Patients with Cardiovascular Disease – New England Journal of Medicine (free)

Editorial: PCSK9 Inhibition to Reduce Cardiovascular Events (free)

See also: Ten Quick Thoughts on FOURIER – Medscape (free registration required) AND Pricey New Cholesterol Drug’s Effect On Heart Disease Is More Modest Than Hoped – NPR Health News (free)

PCSK9 costs 14K per year or 28K for 2 years, would need to treat 66 patients to prevent one event at cost of $1,848,000/ 2 yrs, $924,000/yr” (RT @CMichaelGibson – see tweet)

“Evolocumab did not reduce cardiovascular or death from any cause. There was not even a trend for improvement” (see Medscape commentary above)

 

3 – #ACC17 – Fractional Flow Reserve-Guided Multivessel Angioplasty in Myocardial Infarction – New England Journal of Medicine (free)

Editorial: Complete Revascularization in ST-Elevation Myocardial Infarction? (free)

See also: FFR-Guided Complete Revascularization Tops PCI of Culprit Artery Alone in Acute STEMI – TCTMD (free)

“The advantage in Compare-Acute was mostly due to fewer repeat revascularizations; larger trials are needed to assess hard outcomes.” (TCTMD commentary above).

 

4 – #ACC17 – Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients – New England Journal of Medicine (free)

See also: TAVR or Surgery for Patients with Severe Aortic Stenosis and Intermediate Surgery Risk? – Journal Watch (free)

Mortality and stroke at 2 years were similar with surgery and transcatheter aortic-valve replacement, but different adverse events were associated with each procedure” (from commentary above)

 

5 – #ACC17 – Depression Doubles Risk of Death After Heart Attack, Angina – Latest in Cardiology, American College of Cardiology (free)

Effect persists for years, underscoring the need for mental health screening and treatment”.

 

6 – #ACC17 – AFib Patients Taking Digoxin Have Increased Risk of Death – Latest in Cardiology, American College of Cardiology (free)

 

7 – #ACC17 – Coronary atherosclerosis in indigenous South American Tsimane: a cross-sectional cohort study – The Lancet (link to abstract – $ required for full-text)

See also: ‘Healthiest hearts in the world’ found – BBC News (free) AND Indigenous Bolivians Have Some of the Healthiest Hearts – New York Times (free access to 10 articles per month)

 

8 – #ACC17 – Rivaroxaban or Aspirin for Extended Treatment of Venous Thromboembolism – New England Journal of Medicine (free)

Editorial: Reduced-Intensity Rivaroxaban for the Prevention of Recurrent Venous Thromboembolism (free)

See also: Rivaroxaban Bests Aspirin for Preventing Recurrence of VTE: EINSTEIN CHOICE – TCTMD (free) AND ACC: Even Very Low Dose Rivaroxaban Prevents Recurrent VTE – MedPage Today (free registration required) AND Low-Dose Rivaroxaban vs. Aspirin Reduces Recurrent VTE in EINSTEIN CHOICE – Latest in Cardiology, American College of Cardiology (free)

“The number needed to treat to prevent one VTE was 30 with the 10 mg dose of rivaroxaban and 33 with the 20 mg dose of rivaroxaban” (see Latest in Cardiology commentary above).

 

9 – #ACC17 – Researchers Sound Alarm Over Zika’s Potentially Harmful Heart Effects – Latest in Cardiology, American College of Cardiology (free)

See also: Zika virus also may have harmful heart effects, research shows in first report in adults – ScienceDaily (free) AND Could Zika Affect the Heart? – Journal Watch (free)

 

10 – #ACC17 – Web-Based Lifestyle Counseling Leads to 10-point Reduction in Systolic Blood Pressure – Latest in Cardiology, American College of Cardiology (free)

See also: Lifestyle intervention leads to 10-point drop in systolic blood pressure – ScienceDaily (free) AND Internet-Based Lifestyle Counseling Reduces Hypertension, Improves CVD Risk – CardiologyAdvisor (free) AND ACC: Online Videos Help HTN Adherence: Blood pressure, Framingham risk improved in small trial – MedPage Today (free registration required)

 

Fri, Mar 17 – Top 10 Medical News Stories

17Mar
2017

 

1 – Japanese guidelines for food allergy 2017 – Japanese Society of Allergology (free)

 

2 – Older women taking statins face higher risk of diabetes – ScienceDaily (free) (RT @MaryanneDemasi)

Original article abstract ($ required for full-text): New-Onset Diabetes After Statin Exposure in Elderly Women: The Australian Longitudinal Study on Women’s Health – Drugs & Aging

See also: Cholesterol-lowering statin therapy for healthy people is not as simple as ‘yes’ or ‘no’ – The Pharmaceutical Journal (free) AND BMJ vs The Lancet: there are no winners in the ‘statins war’ – The Conversation (free)

 

3 – In a remote West African village, a revolutionary genetic experiment is on its way — if residents agree to it – STAT News (free) (RT @gatesfoundation)

 

4 – Quick Take Video Summary: Pembrolizumab for Urothelial Carcinoma – New England Journal of Medicine (free)

Original article abstract ($ required for full-text): Pembrolizumab as Second-Line Therapy for Advanced Urothelial Carcinoma – New England Journal of Medicine

 

5 – Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case–time–control study – European Heart Journal – Cardiovascular Pharmacotherapy (free)

See also: Calls for ibuprofen sale restrictions after study finds cardiac arrest risk – The Guardian (free) AND Harmless’ painkillers associated with increased risk of cardiac arrest – EurekAlert (free)

Another study showing the cardiovascular risks of non-steroidal anti-inflammatory drugs.

 

6 – Heart Rhythm Society: expert consensus statements – part 1 (free)

 

7 – Heart Rhythm Society: expert consensus statements – part 2 (free)

 

8 – Zika: Then, now, and tomorrow – World Health Organization (free)

See also: Zika virus and complications – WHO Programme (free)

 

9 – Overview of Zika infection, epidemiology, transmission and control measures – Journal of Infections and Public Health (free)

 

10 – Primary prevention of cardiovascular disease: A review of contemporary guidance and literature – JRSM Cardiovascular Diseases (free)

 

Thu, Mar 16 – Top 10 Medical News Stories

16Mar
2017

 

1 – 2017 AHA/ACC Focused Update of the 2014 AHA/ACC Guideline for the Management of Patients With Valvular Heart Disease (free PDF)

 

2 – Focused Update of the Valvular Heart Disease Guideline Released – Latest in Cardiology, American College of Cardiology (free) (RT @ACCinTouch)

 

3 – ECRI Institute Names Top 10 Patient Safety Concerns for 2017 (free news release / free registration required to download the report)

Source: ECRI’s 2017 Top 10 Patient Safety Concerns – Medscape (free registration required)

“New report examines root causes for serious patient safety events”.

 

4 – What Hospitals Waste – ProPublica (free)

Source: What Hospitals Waste – Medscape (free registration required)

“The nation’s health care tab is sky-high. We’re tracking down the reasons. First stop: A look at all the perfectly good stuff hospitals throw away”

 

5 – Why clinical trial outcomes fail to translate into benefits for patients – Trials (free) (RT @BioMedCentral)

 

6 – Should hospitals — and doctors — apologize for medical mistakes? – The Washington Post (free)

 

7 – Depression Doubles Risk of Death After Heart Attack, Angina – Latest in Cardiology, American College of Cardiology (free) (RT @ACCmediacenter) #ACC17

Effect persists for years, underscoring the need for mental health screening and treatment”

 

8 – Association between concurrent use of prescription opioids and benzodiazepines and overdose: retrospective analysis – The BMJ (free)

See also: Editorial – The growing problem of co-treatment with opioids and benzodiazepines (free)

Patients with concurrent use of opioids and benzodiazepines had a substantially higher risk of an emergency room visit or inpatient admission for opioid overdose.

 

9 – Particulate air pollution and mortality in 38 of China’s largest cities: time series analysis – The BMJ (free)

“Adopting and enforcing tighter air quality standards in China could save 3 million premature deaths each year”

 

10 – Risk of heart failure after community acquired pneumonia: prospective controlled study with 10 years of follow-up – The BMJ (free)

Patients diagnosed with community acquired pneumonia had increased risk of heart failure in the following years.

 

Wed, Mar 15 – Top 10 Medical News Stories

15Mar
2017

 

1 – Pharmacologic Therapy for Type 2 Diabetes: Synopsis of the 2017 American Diabetes Association Standards of Medical Care in Diabetes – Annals of Internal Medicine (free)

 

2 – 2017 Diabetes Care Standards Issued – Physician’s First Watch (free)

 

3 – Variation in Physician Spending and Association With Patient Outcomes – JAMA Internal Medicine (free)

See also: Editorial: Physician Spending and Patient Outcomes (free) AND More Hospitalist Spending Does Not Mean Better Outcomes – Medscape (free registration required)

Higher physician spending was not associated with better outcomes of hospitalized patients.

 

4 – Twitter Is Trending in Academic Medicine – Association of American Medical Colleges (free)

“Within the next decade, you won’t be able to be a successful scholar without having some activity on social media.” (RT @Dr_A_Rashid)

 

5 – Omega-3 Polyunsaturated Fatty Acid (Fish Oil) Supplementation and the Prevention of Clinical Cardiovascular Disease: A Science Advisory from the American Heart Association (free PDF)

See also: Commentary: Omega-3 Fish Oil Supplements – Taking Stock and Awaiting Vital New Studies (free) AND AHA News: Fish oil supplements provide some benefit after heart attack, heart failure (free) AND News Release: Fish oil supplements may help prevent death after a heart attack but lack evidence of cardiovascular benefit for the general population – American Heart Association Science Advisory (free) AND Top Ten Things to Know (free PDF)

 

6 – AHA: Fish Oil OK After Heart Attack, Heart Failure: But no new evidence for use in primary prevention of CVD – MedPage Today (free registration required)

 

7 – Association of Intensive Blood Pressure Control and Kidney Disease Progression in Nondiabetic Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ required for full-text)

In patients with CKD without diabetes, intensive BP control (<130/80 mm Hg) did not improve major renal outcomes over standard BP control (<140/90 mm Hg).

 

8 – Pediatric Urology: Practical Considerations for Urological and Community Practice – Canadian Urological Association Journal (free)

Open Access supplement with 14 updated review articles on the subject.

 

9 – Screen time is associated with adiposity and insulin resistance in children – Archives of Diseases in Childhood (free)

Source: Global Health NOW Newsletter

Children reporting over three hours of watching TV or playing computer games had increased adiposity and risk factors for type 2 diabetes (particularly insulin resistance).

 

10 – Screentime linked to greater diabetes risk among children – The Guardian (free)

Source: Global Health NOW Newsletter

 

Tue, Mar 14 – Top 10 Medical News Stories

14Mar
2017

Mon, Mar 13 – Top 10 Medical News Stories

13Mar
2017

 

1 – 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines, and the Heart Rhythm Society (free PDF)

See also: Executive Summary (free PDF) AND News release: Experts Release Guidelines for Evaluating, Managing Syncope (free) AND Top Ten Things to Know (free PDF)

 

2 – New Guideline: ECG Warranted in Syncope Evaluation: Joint statement does not recommend routine MRI, CT imaging – MedPage Today (free registration required)

 

3 – More than just being open: giving control to authors and credit to peer reviewers – F1000Research blog (free)

See also: The peer-review system for academic papers is badly in need of repair – The Conversation (free) (RT @Onisillos)

See also: Manipulating the peer review process: why it happens and how it might be prevented – LSE Impact of Social Sciences blog (free) (RT @PA_Maday)

See also: You never said my peer review was confidential’ — scientist challenges publisher – Nature News (free)

 

4 – Practice Pointer: Emergency care and resuscitation plans – The BMJ (free)

Infographic and practice points on planning emergency care for future scenarios when people might not have the capacity to communicate their preferences.

 

5 – Eating More — Or Less — Of 10 Foods May Cut Risk Of Early Death – NPR (free)

Original article abstract ($ required for full-text): Association Between Dietary Factors and Mortality from Heart Disease, Stroke, and Type 2 Diabetes in the United States – JAMA

 

6 – Prophylactic hydration to protect renal function from intravascular iodinated contrast material in patients at high risk of contrast-induced nephropathy (AMACING): a prospective, randomized, phase 3, controlled, open-label, non-inferiority trial – The Lancet (link to abstract – $ required for full-text)

See also: Prophylactic hydration to prevent contrast-induced AKI: The AMACING trial – The Bottom line (free)

See also: Contrast-Induced Nephropathy: Signal or Noise? – Medscape It is said that a good experiment raises more questions than it answers. This one surely does that.”  – John Mandrola, MD (free registration required)

Contradicting current guidelines, there was no benefit from prophylactic hydration.

 

7 – Serum creatinine elevation after renin-angiotensin system blockade and long term cardiorenal risks: cohort study – The BMJ

 

8 – Even Small Creatinine Increases After ACE Inhibitor/ARB Treatment Signal Risk – Physician’s First Watch

 

9 – A NOBLE Trial and an Attempt to EXCEL: A Comparison of Two Randomized Trials of Unprotected LMT PCI vs. CABG AND Revascularization of Left Main Disease: Do we EXCEL at Stenting? Or is it More NOBLE to Treat With Surgery?

Commentaries with practical points to consider on the latest trials comparing PCI vs. CABG for left main disease.

 

10 – Reader beware: Science covered in the news is pretty likely to be overturned – STAT News

 

Fri, Mar 10 – Top 10 Medical News Stories

10Mar
2017

 

1 – The Emerging Crisis: Noncommunicable Diseases – Council on Foreign Relations (free) (RT @ghn_news)

Great resource on NCDs.

 

2 – Why gluten-free food is not the healthy option and could increase your risk of diabetes – The Conversation (free)

Research summary: Low gluten diets may be associated with higher risk of type 2 diabetes – American Heart Association Meeting Report Presentation (free)

 

3 – People on treatment with suppressed HIV levels can’t transmit virus: HIV/AIDS group – Reuters Health News (free) (RT @CMichaelGibson)

See also: AIDS United News Release (free) AND Statement (free PDF)

 

4 – A Public-Health Crisis That We Can Fix – The New York Times (free access to 10 articles per month)

“U.S. vehicle deaths have surged an alarming 14% in the last 2 years, likely due to cell phone use” (RT @ghn_news)

 

5 – Surgery or Drugs? Doctors’ Pay May Influence Choice – The New York Times (free access to 10 articles per month)

Original article abstract ($ required for full-text): Provider-Induced Demand in the Treatment of Carotid Artery StenosisVariation in Treatment Decisions Between Private Sector Fee-for-Service vs Salary-Based Military Physicians – JAMA Surgery

 

6 – Yellow Fever – Once Again on the Radar Screen in the Americas – New England Journal of Medicine (free) (RT @Onisillos)

 

7 – Quick Take Video Summary: The IRIS Trial – Imatinib in Chronic Myeloid Leukemia – The New England Journal of Medicine (free)

Original article abstract ($ required for full-text): Long-Term Outcomes of Imatinib Treatment for Chronic Myeloid Leukemia – New England Journal of Medicine

 

8 – ‘Imatinib Changed Everything': Legacy confirmed by long-term data from pivotal trial – MedPage Today (free registration required)

 

9 – Cognitive Impairment – Part 1: Symptoms to Diagnosis & Part 2: Diagnosis to Management – Toward Optimized Practice Clinical Practice Guidelines (free PDF)

 

10 – A guideline for the clinical management of opioid use disorders – Guidelines and Protocols Advisory Committee (free PDF)

 

Thu, Mar 9 – Top 10 Medical News Stories

9Mar
2017

 

1 – Canadian Cardiovascular Society Guidelines for the Management of Dyslipidemia for the Prevention of Cardiovascular Disease in the Adult (free)

 

2 – Screening for Gynecologic Conditions with Pelvic Examination: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorial: Is It Time to Abandon the Routine Pelvic Examination in Asymptomatic Nonpregnant Women? (free)

See also: Are Routine Pelvic Exams A Must? Evidence Is Lacking, Task Force Says – NPR (free)

 

3 – Prophylactic platelet transfusion plus supportive care versus supportive care alone in adults with dengue and thrombocytopenia: a multicentre, open-label, randomised, superiority trial – The Lancet (Link to abstract – $ required for full-text) (RT @Onisillos)

In adults with dengue and thrombocytopenia (≤20.000 platelets per mcl), prophylactic platelet transfusion did not prevent bleeding complications and was associated with more frequent adverse events.

 

4 – Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial – The Lancet (free)

Related commentary: Doxycycline: a first-line treatment for bullous pemphigoid? – The Lancet (free)

 

5 – Clinical Guideline: Evaluation of Abnormal Liver Chemistries – American College of Gastroenterology (free PDF)

Source: PracticalReviews ($ resource to find articles of interest)

 

6 – The International College of Neuro-Psychopharmacology Treatment Guidelines for Bipolar Disorder in Adults (free)

See also: Editorial and related reviews (free)

 

7 – Low carbohydrate diets should be considered for diabetes management – ScienceDaily (free)

See also: Should a Low Carbohydrate Diet be Recommended for Diabetes Management? – Proceedings of the Nutrition Society (free)

Controversial, but interesting point of view. “A carbohydrate restricted diet can provide a safe and effective solution for improving diabetes management and should have a place within the diabetic guidelines”.

 

8 – First Opinion: Few people actually benefit from ‘breakthrough’ cancer immunotherapy – STAT News (free)

 

9 – Carcinoid Heart Disease Guidelines (American College of Cardiology summary with key points to remember) (free)

Original article abstract ($ required for full-text): Diagnosing and Managing Carcinoid Heart Disease in Patients With Neuroendocrine Tumors: An Expert Statement – Journal of the American College of Cardiology

 

10 – 2017 ACC Expert Consensus Decision Pathway for Transcatheter Aortic Valve Replacement in the Management of Adults With Aortic Stenosis: A Report of the American College of Cardiology Task Force on Clinical Expert Consensus Documents (free)

 

Wed, Mar 8 – Top 10 Medical News Stories

8Mar
2017

 

1 – Updated Fact Sheet: Female genital mutilation – World Health Organization

See also: High-quality healthcare needed for girls and women who have experienced female genital mutilation

Today is #WomensDay – “Female Genital Mutilation violates human rights, has NO health benefits & it must NEVER be performed” (RT @WHO)

 

2 – British Association of Dermatologists’ guidelines for the management of contact dermatitis 2017

 

3 – Migraine Linked to Stroke Caused by Cervical Artery Dissection – Physician’s First Watch

Original article: Association Between Migraine and Cervical Artery Dissection – JAMA Neurology

Editorial: Migraine and the Risk of Carotid Artery Dissection in the IPSYS Registry: Are They Related?

 

4 – Antithrombotic Drugs Tied to Elevated Risk for Subdural Hematoma – Physician’s First Watch

Original article abstract ($ required for full-text): Association of Antithrombotic Drug Use With Subdural Hematoma Risk – JAMA

 

5 – Neurocysticercosis infection and disease: A review – Acta Tropica

 

6 – Review: Pulmonary Hypertension – Deutsches Ärzteblatt International

 

7 – Ten key points for the appropriate use of antibiotics in hospitalised patients: a consensus from the Antimicrobial Stewardship and Resistance Working Groups of the International Society of Chemotherapy – International Journal of Antimicrobial Agents

 

8 – Heart Failure Risk Strongly Associated with Inactivity and Obesity – CardioSmart

Original article abstract ($ required for full text): Relationship Between Physical Activity, Body Mass Index, and Risk of Heart Failure – Journal of the American College of Cardiology

 

9 – Risk of serious infections associated with use of immunosuppressive agents in pregnant women with autoimmune inflammatory conditions: cohort study – The BMJ

 

10 – Report: Environmental Hazards Kill 1.7 Million Kids Under 5 Each Year – NPR

 

Tue, Mar 7 – Top 10 Medical News Stories

7Mar
2017

 

1 – The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization

See also: 10 facts on children’s environmental health AND WHO’s work on environmental health

 

2 – Review: Duration of dual antiplatelet therapy in acute coronary syndrome – Heart

 

3 – 2017 Taiwan lipid guidelines for high risk patients – Formosan Medical Association

 

4 – Early versus late initiation of renal replacement therapy in patients with acute kidney injury-a systematic review & meta-analysis of randomized controlled trials – BMC Nephrology

Source: Critical Care Reviews Newsletter

Early initiation of renal replacement therapy was not associated with better outcomes

 

5 – Study: half of the studies you read about in the news are wrong – VOX

“And yes, this could be one of them”

 

6 – The unintended consequences of bundled payments – By Peter Ubel, MD in KevinMD.com (RT @brhospitalist)

 

7 – Paying Doctors For Outcomes Makes Sense in Theory. So Why Doesn’t it Work in the Real World? – By Stephen Soumerai and Ross Koppel in The Health Care Blog (RT @RasoiniR)

 

8 – Feeling Lonely? Too Much Time On Social Media May Be Why – NPR

Original Article: Social Media Use and Perceived Social Isolation Among Young Adults in the U.S. – American Journal of Preventive Medicine

See also: Association Between Social Media Use and Depression Among U.S. Young Adults – Depression and Anxiety

“This study can’t nail down causation. It could be that when people feel socially isolated, they go online a lot in an attempt to feel less lonely”

 

9 – Richard Lehman’s weekly review of medical journals (6 March 2017) – The BMJ Blogs

 

10 – Unscrambling The Nutrition Science On Eggs – NPR

 

Mon, Mar 6 – Top 10 Medical News Stories

6Mar
2017

 

1 – Guideline: Recommendations on behavioural interventions for the prevention and treatment of cigarette smoking among school-aged children and youth – Canadian Task Force on Preventive Health Care

See also: Summary of recommendations for clinicians and policy-makers AND Clinician FAQ

 

2 – Wilderness Medical Society Practice Guidelines for Prevention and Management of Avalanche and Nonavalanche Snow Burial Accidents

Source: MedicalXpress – New avalanche and snow burial practice guidelines released

 

3 – Diagnosis and Management of Acute Deep Vein Thrombosis – Latest in Cardiology, American College of Cardiology

Original article abstract ($ required for full text): Diagnosis and management of acute deep vein thrombosis: a joint consensus document from the European society of cardiology working groups of aorta and peripheral circulation and pulmonary circulation and right ventricular function

Key points to remember from the new joint consensus document from the European Society of Cardiology

 

4 – Baseline Prevalence of Birth Defects Associated with Congenital Zika Virus Infection — Massachusetts, North Carolina, and Atlanta, Georgia, 2013–2014 – CDC Morbidity and Mortality Weekly Report (MMWR)

See also: CIDRAP – US study shows Zika-type birth defects rise 20-fold

See also: New York Times – Birth Defects Rise Twentyfold in Mothers With Zika, C.D.C. Says

 

5 – Effect of beta-blockers on perioperative outcomes in vascular and endovascular surgery: a systematic review and meta-analysis – British Journal of Anaesthesia

Source: Medscape Week in Review Newsletter

Earlier studies and guidelines suggested beta-blockers might be of benefit for high-risk patients planning vascular surgery, but this meta-analysis confirms the current view that beta-blockers do not improve perioperative outcomes in vascular and endovascular surgery

 

6 – #WorldHearingDay (3 March 2017) – Updated Fact Sheet: Deafness and hearing loss – World Health Organization

See also: Prevention of Blindness and Deafness Programme – World Health Organization

360 million people worldwide have disabling hearing loss. 32 million of them are children

 

7 – The Changing Face of Clinical Trials Series: Informed Consent – New England Journal of Medicine

 

8 – Is Excessive Resource Utilization an Adverse Event? – JAMA (RT @jdimick1)

 

9 – Study: High-dose flu vaccine may cut deaths in seniors – CIDRAP

Original Article: Comparative Effectiveness of High-Dose Versus Standard-Dose Influenza Vaccines Among US Medicare Beneficiaries in Preventing Postinfluenza Deaths During 2012–2013 and 2013–2014 – The Journal of Infectious Diseases

Editorial: Moving Toward Improved Influenza Vaccines

 

10 – Doctors No Longer Rush to Cut the Umbilical Cord – The New York Times

 

Fri, Mar 3 – Top 10 Medical News Stories

3Mar
2017

 

1 – Check the source: WHO-validated websites provide trustworthy information on vaccine safety – World Health Organization (RT @glassmanamanda)

See also: Vaccine Safety Net Member Websites

 

2 – The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis – The Lancet Public Health

Related Editorial: Alcohol and Blood Pressure

Source: Medscape – Studies Suggest Cardiovascular Sweet Spot at Two Drinks per Day (free registration required)

“Cutting back on moderate alcohol intake does not lower blood pressure. It’s a different story for heavier drinkers” (RT @theheartorg)

 

3 – Viewpoint: Management of Type 2 Diabetes in 2017: Getting to Goal – JAMA (RT @davidludwigmd)

Summary on the management of Type 2 Diabetes with emphasis on new drugs

 

4 – Complications More Common in Teens and Young Adults with Type 2 than Type 1 Diabetes – Physician’s First Watch

Original Article Abstract ($ required for full-text): Association of Type 1 Diabetes vs Type 2 Diabetes Diagnosed During Childhood and Adolescence With Complications During Teenage Years and Young Adulthood – JAMA

Complications were frequent in both groups, but more frequent in those with Type 2 Diabetes

 

5 – Subcutaneous unfractionated heparin for the initial treatment of venous thromboembolism – Cochrane Database of Systematic Reviews

Source: Evidence Alerts (free resource to find articles of interest in all specialties)

Subcutaneous Unfractionated Heparin seems to be as safe and effective as Intravenous Heparin or Low Molecular Weight Heparin

 

6 – New WHO Fact Sheet: Chagas disease (American trypanosomiasis) – World Health Organization (RT @greg_folkers)

 

7 – Treating Pregnant Women for Subclinical Thyroid Disease Unlikely to Improve Cognition in Offspring – Physician’s First Watch

See also: Multicenter study finds no benefit to treating mild thyroid dysfunction during pregnancy – ScienceDaily

Original Article Abstract ($ required for full-text): Treatment of Subclinical Hypothyroidism or Hypothyroxinemia in Pregnancy – New England Journal of Medicine

 

8 – Clinical Practice Guideline: Benign Paroxysmal Positional Vertigo (Update) Executive Summary – American Academy of Otolaryngology—Head and Neck Surgery Foundation

Plain Language Summary: Benign Paroxysmal Positional Vertigo

Source: Medscape – New Guidelines for Benign Paroxysmal Positional Vertigo

 

9 – Financial toxicity: 1 in 3 cancer patients have to turn to friends or family to pay for care – STAT News

 

10 – A comprehensive review of the diagnosis and management of prosthetic joint infections in the absence of positive cultures – Journal of Infection and Public Health

 

Thu, Mar 2 – Top 10 Medical News Stories

2Mar
2017

 

1 – Global Skin Disease Morbidity and Mortality: An Update from the Global Burden of Disease Study 2013 – JAMA Dermatology (RT @EricTopol)

 

2 – When is proton pump inhibitor use appropriate? – BMC Med

 

3 – Effective and safe proton pump inhibitor therapy in acid-related diseases – A position paper addressing benefits and potential harms of acid suppression – BMC Med

 

4 -Long-acting muscarinic antagonist (LAMA) plus long-acting beta-agonist (LABA) versus LABA plus inhaled corticosteroid (ICS) for stable chronic obstructive pulmonary disease (COPD) – The Cochrane Library (Link to abstract – $ required for full-text)

News Release: Which combination of inhaled medications are safe and effective for chronic obstructive pulmonary disease (COPD)

Source: EvidenceAlerts (free resource to find articles of interest in all specialties)

In accordance with the recently updated GOLD guideline, when two classes of medications are required, long-acting beta-agonists (LABA) combined with long-acting muscarinic antagonists (LAMA) seems a better choice than a LABA combined with inhaled corticosteroids. 

 

5 – Adiposity and cancer at major anatomical sites: umbrella review of the literature – The BMJ

See also: Nearly a Dozen Cancers Tied to Obesity: Strongest links in cancers of the digestive organs, breast – MedPage Today (free registration required)

 

6 – Increased risk of 11 types of cancer linked to being overweight, researchers warn – The Guardian

“Study shows strong evidence of a link between excess body fat and cancers of the colon, breast, pancreas and ovary among others”

 

7 – Draft Recommendation Statement: Vision in Children Ages 6 Months to 5 Years: Screening – U.S. Preventive Services Task Force

Source: Medscape – USPSTF Issues Draft Vision Screening Recommendations for Young Kids (free registration required)

 

8 – Acute myocardial infarction hospital admissions and deaths in England: a national follow-back and follow-forward record-linkage study – The Lancet Public Health

Source: Imperial College London – Warning signs might have been missed in one in six England heart attack deaths

See also: Early warning signs of heart attacks ‘being missed’ – BBC

 

9 – Hepatitis C drugs re-energize global fight over patents – Nature News

 

10 – Human cases of bird flu are surging, alarming public health officials – STAT News

See also: H7N9 Flu Outbreak Largest Yet: But risk of sustained transmission among people remains low: WHO – MedPage Today (free registration required)

 

Wed, Mar 1 – Top 10 Medical News Stories

1Mar
2017

 

1 – Second Korean guidelines for the management of Crohn’s disease – Intestinal Research

 

2 – Second Korean guidelines for the management of ulcerative colitis – Intestinal Research

 

3 – Thiazolidinediones and Advanced Liver Fibrosis in Nonalcoholic Steatohepatitis: A Meta-analysis – JAMA Internal Medicine

Thiazolidinedione therapy was associated with histological improvement in advanced fibrosis, fibrosis of any stage and NASH resolution. Side effects included a mean 2.7% weight gain compared with controls and leg edema, but the small sample size of included trials (n = 516 patients) prevented evaluation of more serious adverse effects. Since there is no data showing improvement in clinical outcomes such as development of ascites, encephalopathy, need for liver transplantation, or liver-related death, a related commentary (see below) suggests it is premature to recommend pioglitazone in the general management of this condition.

 

4 – The Role of Pioglitazone in the Management of Nonalcoholic Steatohepatitis: Are We There Yet? – JAMA Internal Medicine

 

5 – Enabling breastfeeding for mothers and babies – Cochrane Special Collection

News release: New Cochrane Library Special Collection: Enabling breastfeeding for mothers and babies

 

6 – Why being rude to doctors is bad for them and you – World Economic Forum

See also: What Happens When Parents Are Rude in the Hospital – The New York Times

Original Article Abstract ($ required for full text): Rudeness and Medical Team Performance – Pediatrics

 

7 – Not Just Nausea and Vomiting: Cancer Docs Now Worry About ‘Financial Toxicity – WBUR (RT @FutureDocs)

 

8 – Review: When Is Parenteral Nutrition Appropriate? – Journal of Parenteral and Enteral Nutrition

 

9 -Review: What is hidradenitis suppurativa? – Canadian Family Physician

 

10 – WHO identifies antibiotic-resistant ‘priority pathogens’ – CIDRAP

 

Tue, Feb 28 – Top 10 Medical News Stories

28Feb
2017

 

1 – Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics – World Health Organization

News Release: WHO publishes list of bacteria for which new antibiotics are urgently needed

See also: WHO Programme on Antimicrobial resistance

 

2 – WHO releases list of world’s most dangerous superbugs – STAT News

 

3 – Deadly, Drug-Resistant ‘Superbugs’ Pose Huge Threat, W.H.O. Says – The New York Times

 

4 – How to Get Patients to Take More Control of Their Medical Decisions – The Wall Street Journal (RT @EricTopol)

“For years, people have been urged be more active in their own care. Now providers are giving them better tools to make that happen”

 

5 – Why universities and academics should bother with public engagement – The Conversation

 

6 – Abraar Karan: Publication should not be the endgame of medical research – The BMJ Blogs

 “Social Media – New Way for Medical Research Dissemination” (RT @pascalmeier74)

See also: A Primer on How to Create a Visual Abstract – PDF (another tendency that might increase engagement with medical research)

 

7 – Is Chronic Stress Likely to Make You Fat? High cortisol levels in hair samples tied to obesity persistence – MedPage Today (free registration required)

Original Article: Hair cortisol and adiposity in a population-based sample of 2,527 men and women aged 54 to 87 years – Obesity

 

8 – Richard Lehman’s weekly review of medical journals – The BMJ Blogs

 

9 – Care of the Adolescent After an Acute Sexual Assault – American Academy of Pediatrics

 

10 – New Guidance for Caring for Adolescent Sexual Assault Victims Published – Physician’s First Watch

 

Mon, Feb 27 – Top 10 Medical News Stories

27Feb
2017

 

1 – Depression and Other Common Mental Disorders: Global Health Estimates – World Health Organization

WHO has just released a new global report on health estimates on depression. The number of people living with depression is increasing, 18% between 2005 and 2015, and it is now the largest cause of disability worldwide

 

2 – Depression: Updated Fact Sheet – World Health Organization

 

3 – Evidence-based guidelines for the use of tracheostomy in critically ill patients – Journal of Critical Care

Source: Critical Care Reviews Journal Watch

 

4 – Proven: People Don’t Take Medicine They Can’t Afford! – Forbes (RT @spkalantri And @OphiraG)

 

5 – Scalp Cooling Caps Help Prevent Hair Loss from Chemotherapy – Physician’s First Watch

JAMA Article 1 – Link to abstract ($ required for full text): Effect of a Scalp Cooling Device on Alopecia in Women Undergoing Chemotherapy for Breast Cancer: The SCALP Randomized Clinical Trial

JAMA Article 2 – Link to abstract ($ required for full text): Association Between Use of a Scalp Cooling Device and Alopecia After Chemotherapy for Breast Cancer

 

6 – Choosing Wisely: Cervical Screening Tests and Treatments to Avoid – Physician’s First Watch

See also: Choosing Wisely List – American Society for Colposcopy and Cervical Pathology

 

7 – The contribution of poor and rural populations to national trends in reproductive, maternal, newborn, and child health coverage: analyses of cross-sectional surveys from 64 countries – The Lancet

Editorial: Trends in health inequalities in developing countries

 

8 – Mexico’s sugar tax leads to fall in consumption for second year running – The Guardian

“Health experts are watching the progress of the tax to see if it will lower the rates of obesity-related diseases and type 2 diabetes”

 

9 – The year in cardiology 2016: coronary interventions – European Heart Journal

 

10 – Review: Postoperative pulmonary complications – British Journal of Anaesthesia

 

Fri, Feb 24 – Top 10 Medical News Stories

24Feb
2017

 

1 – Diabetic Retinopathy: A Position Statement by the American Diabetes Association

Source: Medscape – First ADA Guidance on Diabetic Retinopathy in 15 Years (free registration required)

 

2 – When Evidence Says No, But Doctors Say Yes: Years after research contradicts common practices, patients continue to demand them and doctors continue to deliver. The result is an epidemic of unnecessary and unhelpful treatment – ProPublica (RT @HenrikVogt and @MaryanneDemasi)

This very interesting commentary went “viral” in the medical community.

The essence of medical professionalism is not to say “yes” but to say “no”” (RT @HenrikVogt)

 

3 – Caesarean sections and for-profit status of hospitals: systematic review and meta-analysis – BMJ Open

Cesarean sections (CS) are more likely to be performed by for-profit hospitals as compared with non-profit hospitals. The researchers recommend examination of incentive structures of for-profit hospitals including reimbursement policies to decrease unnecessary CS and promote strategies that encourage best clinical judgement and outcome

 

4 – Fruit and vegetable intake and the risk of cardiovascular disease, total cancer and all-cause mortality–a systematic review and dose-response meta-analysis of prospective studies – International Journal of Epidemiology

 

5 – Eating more fruits and vegetables may prevent millions of premature deaths – Imperial College London

 

6 – Bad Hospital Design Is Making Us Sicker – The New York Times (RT @KentBottles)

 

7 – Cancer Prevention Overview – PDQ Cancer Information Summaries: National Cancer Institute (US)

 

8 – Antiplatelet Agents and the Prevention of Spontaneous Preterm Birth: A Systematic Review and Meta-analysis – Obstetrics & Gynecology

Source: EvidenceAlerts (free resource to find articles of interest in all specialties – registration required)

Antiplatelet agents prevent spontaneous preterm birth in pregnant women at risk for preeclampsia 

 

9 – Implanted Cardiac Devices Pass an MRI Test – Physician’s First Watch

See also: MRI May Be Safe with Many Non-MRI-Conditional Heart Devices – MedPage Today

Original Article Abstract ($ required for full text): Assessing the Risks Associated with MRI in Patients with a Pacemaker or Defibrillator – New England Journal of Medicine

Nonthoracic MRI was safe if used with strict protocol

 

10 – Liraglutide Associated with Less Progression in Prediabetes – Physician’s First Watch

Original Article Abstract ($ required for full text): 3 years of liraglutide versus placebo for type 2 diabetes risk reduction and weight management in individuals with prediabetes: a randomised, double-blind trial – The Lancet

Interesting, but they could have tested Liraglutide against Metformin, the drug usually used for this purpose

 

Thu, Feb 23 – Top 10 Medical News Stories

23Feb
2017

 

1 – Guidelines on hepatitis B and C testing – World Health Organization

See also: World Health Organization’s Global Hepatitis Programme web site

 

2 – News Release: WHO issues first viral hepatitis testing guidelines – World Health Organization

 

3 – Testosterone Therapy: Five New Reports Offer a Mixed Bag – Physician’s First Watch

Good summary of 5 reports just published in JAMA and JAMA Internal Medicine

 

4 – Editorial: Further Elucidation of the Potential Benefits of Testosterone Therapy in Older Men – JAMA Internal Medicine

 

5 – Long-term kidney outcomes among users of proton pump inhibitors without intervening acute kidney injury – Kidney International

Source: Popular heartburn drugs linked to gradual yet ‘silent’ kidney damage – Medical Xpress

From related editorial ($) Proton pump inhibitors and chronic kidney disease: is it time to sound the alarm?Although the study does not prove causality, the robustness of the findings in two cohorts suggests a need for further study and reevaluation of the safety of these agents for widespread, non-prescription use”

 

6 – Drug misuse prevention: targeted interventions – NICE Guideline

News Release: Local authorities need to work together with nightclubs and gyms to prevent drug misuse

 

7 – Overdiagnosis Is a Problem in Pediatrics, Too: Abnormal test results pursued endlessly without a clinical benefit – MedPage Today (free registration required)

See also: Overdiagnosis, Overtreatment Too Common in Pediatric Care – Medscape (free registration required)

See also: Use of Low-Value Pediatric Services Among the Commercially Insured – Pediatrics (this open-access article has a list of 20 Low-Value Pediatric Services)

Original article abstract ($ required for full-text): Update on Pediatric Overuse – Pediatrics

 

8 – Long term effects of once-only flexible sigmoidoscopy screening after 17 years of follow-up: the UK Flexible Sigmoidoscopy Screening randomised controlled trial – The Lancet

A single sigmoidoscopy between 55 and 64 years of age confers reduction in colorectal cancer incidence and mortality with long-term benefits

 

9 – Flexible sigmoidoscopy screening: is once enough? – The Lancet

 

10 – New screening test cuts bowel cancer risk by a third, study finds – The Guardian

 

Wed, Feb 22 – Top 10 Medical News Stories

22Feb
2017

 

1 – Costs Associated With Access Site and Same-Day Discharge Among Medicare Beneficiaries Undergoing Percutaneous Coronary Intervention – JACC: Cardiovascular Interventions

See also: Editorial Comment: Strengths and Limitations of Using Cost Evaluations to Inform Cardiovascular Care

Source: MedPage Today – Radial-First PCI, Same-Day Discharge Could Save Big Bucks (free registration required)

 

2 – YouTube Video – A world-renowned cardiologist: The Dietary Guidelines Are A Lie! Salim Yusuf full speech 2017 (RT @DrAseemMalhotra And @drjohnm)

Controversial, but interesting point of view

 

3 – MD Anderson Benches IBM Watson In Setback For Artificial Intelligence In Medicine – Forbes

 

4 – Wearable Fitness Devices Don’t Seem to Make You More Fit – The New York Times (RT @RasoiniR)

 

5 – Why should we worry about conflict of interest? – Janice Boughton, MD in KevinMd.com

 

6 – 2017 Infectious Diseases Society of America’s Clinical Practice Guidelines for Healthcare-Associated Ventriculitis and Meningitis – Clinical Infectious Diseases

 

7 – Multidonor intensive faecal microbiota transplantation for active ulcerative colitis: a randomised placebo-controlled trial – The Lancet (Link to abstract – $ required for full-text)

 

8 – Fecal Transplantation a Potential New Treatment for Ulcerative Colitis – Physician’s First Watch

 

9 – Long-term Outcomes After Autologous Hematopoietic Stem Cell Transplantation for Multiple Sclerosis – JAMA Neurology

 

10 – Autologous Stem Cell Transplantation for MS: Progression-Free Survival Seen in Nearly Half of Patients – Physician’s First Watch

 

Tue, Feb 21 – Top 10 Medical News Stories

21Feb
2017

Mon, Feb 20 – Top 10 Medical News Stories

20Feb
2017

 

1 – 2017 Recommendations for Preventive Pediatric Health Care – American Academy of Pediatrics

See also: ​​​​​​​​​​ Periodicity Schedule: Recom​​mendations from the Am​erican Academy of Pediatrics for screenings and assessments at each well-child visit from infancy through adolescence And Bright Futures/AAP Periodicity Schedule (PDF – all recommendations in chart form)

Source: Medscape – AAP Updates Preventive Care Guidelines, Targets HIV, Depression Screening (free registration required)

 

2 – Efficacy and Safety of Nonoperative Treatment for Acute Appendicitis: A Meta-analysis – Pediatrics (Link to abstract – $ required for full-text)

Nonoperative treatment was safe and effective as initial treatment for 97% of children. During follow up appendicitis recurred in 14% of the children who did not have surgery. At final reported follow-up (range 8 weeks to 4 years), nonoperative treatment remained effective (no appendectomy performed) in 79% of children

 

3 – Antibiotics, not surgery, could treat appendicitis in children, study suggests – The Guardian

 

4 – Selective serotonin reuptake inhibitors versus placebo in patients with major depressive disorder. A systematic review with meta-analysis and Trial Sequential Analysis – BMC Psychiatry (RT @HenrikVogt)

This study suggests SSRIs are of questionable benefit for patients with depression

 

5 – Do the right thing: Let’s confront both health care underuse and overuse – Tincture (RT @PaulGlasziou)

 

6 – The evidence for vaccine safety is abundant. That will be $100,000, please. – The Washington Post (RT @greg_folkers)

 

7 – Bill and Melinda Gates – 2017 Annual Letter

“For every dollar spent on childhood immunizations, you get $44 in economic benefits.”

 

8 – Osimertinib or Platinum–Pemetrexed in EGFR T790M–Positive Lung Cancer – New England Journal of Medicine (Link to abstract – $ required for full-text)

See also: Quick Take Video Summary: The AURA3 Trial

 

9 – Impact of Enhanced Recovery After Surgery and Fast Track Surgery Pathways on Healthcare-associated Infections: Results from a Systematic Review and Meta-analysis – Annals of Surgery (link to abstract – $ required for full-text)

See also: ERAS Society List of Guidelines

Source: EvidenceAlerts (free resource to find articles of interest in all specialties)

Enhanced Recovery After Surgery (ERAS) and Fast Track Surgery (FTS) protocols were associated with a significant reduction in healthcare-associated infections

 

10 – From Vector To Zoonotic: A Glossary For Infectious Diseases – NPR

 

Fri, Feb 17 – Top 10 Medical News Stories

17Feb
2017

 

1 – 10 ways to improve the quality of maternal and newborn care in health facilities – World Health Organization

See also: Global Strategy for Women’s, Children’s and Adolescents’ Health, 2016-2030 And Standards for improving quality of maternal and newborn care in health facilities And WHO recommendations on antenatal care for a positive pregnancy experience

 

2 – Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data – The BMJ

This meta-analysis showed a protective effect of vitamin D against acute respiratory infection. The authors suggest their findings support the introduction of public health measures such as food fortification to improve vitamin D status

 

3 – Related Editorial: Do vitamin D supplements help prevent respiratory tract infections? – The BMJ

A clinically useful effect remains uncertain despite hints in a new analysis… current evidence does not support the use of vitamin D supplementation to prevent disease, except for those at high risk of osteomalacia, currently defined as 25-hydroxyvitamin D levels less than 25 nmol/L”

 

4 – Vitamin D supplements & acute respiratory infections – BMJ Press Release (RT @trished)

 

5 – State of Global Air 2017: Your source for the latest global, regional, and country-specific data on air quality and health – Health Effects Institute & Institute for Health Metrics and Evaluation

New comprehensive resource on the subject

 

6 – State of Global Air 2017 Report – Health Effects Institute & Institute for Health Metrics and Evaluation

 

7 – Efficacy of Some Wearable Devices Compared with Spray-On Insect Repellents for the Yellow Fever Mosquito, Aedes aegypti (L.) (Diptera: Culicidae) – Journal of Insect Science

Source: For mosquito repellents, stick with the spray – Medical Xpress

None of the bracelets caused any significant reduction in mosquito attraction. Bracelets in general do not offer adequate protection from mosquito bites.

 

8 – Bariatric Surgery versus Intensive Medical Therapy for Diabetes — 5-Year Outcomes – New England Journal of Medicine (link to abstract – $ required for full-text)

 

9 – Benefits of Bariatric Surgery in Diabetic Patients Persist at 5 Years – Physician’s First Watch

 

10 – Point of View: Prostate Cancer 2017: Light at the End of the Tunnel? – Broome Docs

 

Thu, Feb 16 – Top 10 Medical News Stories

16Feb
2017

 

1 – Drugs don’t cure everything – doctors can be helped to prescribe other options – The Conversation

 

2 – Handbook of Non-Drug interventions – The Royal Australian College of General Practitioners (RACGP) 

Very Interesting and Useful Resource

 

3 – Management of Patients on Non–Vitamin K Antagonist Oral Anticoagulants in the Acute Care and Periprocedural Setting: A Scientific Statement from the American Heart Association (PDF)

 

4 – Guidance released on acute care, periprocedural management of patients on NOACs – ACP Hospitalist

 

5 – Taxes and Subsidies for Improving Diet and Population Health in Australia: A Cost-Effectiveness Modelling Study – PLOS Medicine

 

6 – Why the government should tax unhealthy foods and subsidise nutritious ones – The Conversation

 

7 – Epinephrine for First-aid Management of Anaphylaxis – American Academy of Pediatrics Clinical Report

Source: Medscape – AAP Updates Guidance on Epinephrine Use for Anaphylaxis (free registration required)

Epinephrine is the medication of choice for the initial treatment of anaphylaxis. All other medications, including H1-antihistamines and bronchodilators such as albuterol, provide adjunctive treatment but do not replace epinephrine

 

8 – Mixed pathologies including chronic traumatic encephalopathy account for dementia in retired association football (soccer) players – Acta Neuropathologica

 

9 – CTE found in former soccer players, study shows – CNN

“Chronic Traumatic Encephalopathy (CTE) found in former soccer players, like US football players” (RT@CMichaelGibson)

 

10 – Soccer Players Could Be at Risk for CTE – Physician’s First Watch

 

Wed, Feb 15 – Top 10 Medical News Stories

15Feb
2017

 

1 – Noninvasive Treatments for Acute, Subacute, and Chronic Low Back Pain: A Clinical Practice Guideline From the American College of Physicians

Given that most patients with acute or subacute low back pain improve over time regardless of treatment, clinicians and patients should select nonpharmacologic treatment as first option. The use of opioids should be avoided if possible.

 

2 – Systemic Pharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline

 

3 – Nonpharmacologic Therapies for Low Back Pain: A Systematic Review for an American College of Physicians Clinical Practice Guideline

 

4 – ACP Guideline: Start with Nonpharmacologic Treatments for Low Back Pain – Physician’s First Watch

 

5 – Lower Back Ache? Be Active and Wait It Out, New Guidelines Say – The New York Times

 

6 – Multivitamins a waste of money and just create ‘very expensive urine’ – The Guardian (RT @RasoiniR)

 

7 – Socioeconomic status and the 25 × 25 risk factors as determinants of premature mortality: a multicohort study and meta-analysis of 1·7 million men and women – The Lancet

In a meta-analysis from 48 cohort studies performed in high-income countries with data from more than 1.7 million individuals, low social rank accounted for 18·9% (men) and 15·3% (women) of all adult deaths, comparable to that of other major risk factors. The authors suggest that socioeconomic adversity should be included as a modifiable risk factor in local and global health strategies

 

8 – Social rank: a risk factor whose time has come? – The Lancet

 

9 – Pulmonary hypertension associated with left-sided heart disease – Swiss Medical Weekly

Source: 270th Critical Care Reviews Newsletter

 

10 – Do vegetarians live longer? This is what the latest research says – World Economic Forum

See also: Vegetarian diet and all-cause mortality: Evidence from a large population-based Australian cohort – the 45 and Up Study (link to abstract – $ required for full-text)

This study suggests there is no difference in all-cause mortality between vegetarians and non-vegetarians and that differences observed in other studies may occur because vegetarians have healthier lifestyle behaviors than non-vegetarians

 

Tue, Feb 14 – Top 10 Medical News Stories

14Feb
2017

 

1 – Selective versus routine use of episiotomy for vaginal birth – Cochrane Library

Routine episiotomy is not justified by current evidence

 

2 – Removal of all ovarian tissue versus conserving ovarian tissue at time of hysterectomy in premenopausal patients with benign disease: study using routine data and data linkage – The BMJ

In a cohort of women aged 35-45 who underwent hysterectomy for benign conditions, those who had ovarian conservation had a significantly lower risk of ischemic heart disease, cancer and all-cause mortality compared with those who had bilateral ovarian removal

 

3 – #EpilepsyDay (13 February) – Epilepsy Fact Sheet – World Health Organization

 

4 – Long-term dietary quality and risk of developing rheumatoid arthritis in women – Annals of Rheumatic Diseases (link to abstract – $ required for full-text)

 

5 – Healthy Diet Cuts Women’s Risk of New-Onset RA: Inverse association strongest for seropositive disease – MedPage Today (free registration required)

 

6 – Effect of Intensive Blood Pressure Control on Gait Speed and Mobility Limitation in Adults 75 Years or Older: A Randomized Clinical Trial – JAMA Internal Medicine (Link to abstract – $ required for full-text)

 

7 – SPRINT: Intensive BP Lowering in Older Adults Doesn’t Appear to Affect Physical Function – Physician’s First Watch

 

8 – Richard Lehman’s weekly review of medical journals – The BMJ Blog Arquive

 

9 – Perioperative Management of Direct Oral Anticoagulants (DOACs): A Systemic Review – Health Services Insights

Source: 270th Critical Care Reviews Newsletter

 

10 – Intracerebral Hemorrhage – Journal of Stroke (series of articles on the subject)

Source: 270th Critical Care Reviews Newsletter

 

Editorial: Intracerebral Hemorrhage: Large Disease Burden but Less Therapeutic Progress

 

Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update

 

Imaging of Intracranial Hemorrhage

 

Spontaneous Intracerebral Hemorrhage: Management

 

Mon, Feb 13 – Top 10 Medical News Stories

13Feb
2017

 

1 – Tight Glycemic Control in Critically Ill Children – New England Journal of Medicine

“Critically ill children with hyperglycemia did not benefit from tight glycemic control targeted to a blood glucose level of 80 to 110 mg per deciliter, as compared with a level of 150 to 180 mg per deciliter”

 

2 – Epidemic of untreatable back and neck pain costs billions, study finds – The Guardian

 

3 – Improving how physicians working in hospital settings prescribe antibiotics – The Cochrane Library

 

4 – Podcast: Improving how antibiotics are prescribed by physicians working in hospital settings – Cochrane Library

 

5 – The effect of a reduction in alcohol consumption on blood pressure: a systematic review and meta-analysis – The Lancet Public Health (RT @hswapnil and @drjohnm)

More evidence that less alcohol improves hypertension

 

6 – Comment: Alcohol and blood pressure – The Lancet Public Health

 

7 – The three questions that every patient should ask their doctor – The Guardian

 

8 – Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open

Despite widespread multimorbidity, more than three-quarters of ongoing trials assessing interventions for patients with chronic conditions excluded patients with concomitant chronic conditions. This indicates that the external validity or generalisability of much of the current evidence is relatively weak.

 

9 – Proton Pump Inhibitors Do Not Reduce the Risk of Esophageal Adenocarcinoma in Patients with Barrett’s Esophagus: A Systematic Review and Meta-Analysis – PLOS One

Source: PracticeUpdates – PPIs Do Not Reduce the Risk of Esophageal Adenocarcinoma Associated With Barrett’s Esophagus (free registration required)

 

10 – Coronary Calcium in Early Middle Age Associated with Increased CHD Risk – Physician’s First Watch

 

Fri, Feb 10 – Top 10 Medical News Stories

10Feb
2017

 

1 – Thromboprophylaxis after Knee Arthroscopy and Lower-Leg Casting – New England Journal of Medicine (link to abstract – $ required for full-text)

Prophylaxis with low-molecular-weight heparin after knee arthroscopy or during immobilization due to casting was not effective for the prevention of venous thromboembolism

 

2 – Quick Take Video Summary: Preventing Venous Thromboembolism after Arthroscopy and Casting – New England Journal of Medicine

 

3 – Clinical Decisions: Thromboprophylaxis after Knee Arthroscopy – New England Journal of Medicine

 

4 – Association of Coronary Artery Calcium in Adults Aged 32 to 46 Years With Incident Coronary Heart Disease and Death – JAMA Cardiology

The presence of coronary artery calcium identified on a computed tomographic scan in asymptomatic adults aged 32 to 46 years was associated with an increased risk of fatal and nonfatal coronary heart disease during 12.5 years of follow-up

 

5 – German Guidelines on Screening, Diagnosis and Treatment of Alcohol Use Disorders – European Addiction Research

 

6 – Why your doctor’s advice to take all your antibiotics may be wrong – STAT News (RT @CIDRAP and @HelenBranswell)

 

7 – 3rd ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 3) – Annals of Oncology

 

8 – Cancer screening in the United States, 2017: A review of current American Cancer Society guidelines and current issues in cancer screening – CA: A Cancer Journal for Clinicians

 

9 – Early enteral nutrition in critically ill patients: ESICM clinical practice guidelines – Intensive Care Medicine

 

10 – MAP: Find Out What New Viruses Are Emerging In Your Backyard – NPR

 

Thu, Feb 9 – Top 10 Medical News Stories

9Feb
2017

 

1 – Stroke Compendium – Circulation Research (Series of Open Access Articles on The Subject)

Source: Critical Care Reviews Newsletter

 

Editorial: Introduction to the Stroke Compendium

 

Global Burden of Stroke

 

Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke

 

Stroke Risk Factors, Genetics, and Prevention

 

Stroke Caused by Extracranial Disease

 

Stroke Caused by Atherosclerosis of the Major Intracranial Arteries

 

Cardioembolic Stroke

 

Cryptogenic Stroke: Research and Practice

 

Acute Ischemic Stroke Therapy Overview

 

Heart–Brain Axis: Effects of Neurologic Injury on Cardiovascular Function

 

Vascular Cognitive Impairment

 

2 – Study: Vancomycin should be go-to drug for severe Clostridium difficile – CIDRAP

 

3 – Turning the Tide Against Cholera – The New York Times (RT @glassmanamanda)

 

4 – The Need to Optimize Adolescent Immunization – Pediatrics

 

5 – Practical Approaches to Optimize Adolescent Immunization – Pediatrics

 

6 – ACP Internist Weekly – American College of Physicians

Selection of Internal Medicine News for The Week of February 7, 2017

 

7 – What’s the Role of NSAIDs in Back Pain? Meta-analysis says “minimal” but diagnosis can confound (free registration required)

Link to original article abstract ($ required for full-text): Non-steroidal anti-inflammatory drugs for spinal pain: a systematic review and meta-analysis

See also: Non-steroidal anti-inflammatory drugs for low back pain with sciatica – Cochrane Library

“At present, there are no simple analgesics that provide clinically important effects for spinal pain over placebo”

 

8 – Point of View: It’s time for journalists to stop using the word ‘controversial’ to describe medical science – Health News Review

 

9 – Open Access 2016: A Year of Price Bargaining, Preprints, and a Pirate – Absolutely Maybe (RT @hildabast)

 

10 – Review: Neurotrauma Resuscitation: Pearls & Pitfalls – EmDocs (RT @gregorprosen)

 

Wed, Feb 8 – Top 10 Medical News Stories

8Feb
2017

 

1 – Recommended Immunization Schedule for Adults Aged 19 Years or Older, United States, 2017 – Annals of Internal Medicine

 

2 – Recommended Immunization Schedules for Adults – Centers for Disease Control and Prevention (CDC)

 

3 – 2017 Adult Immunization Schedule Released – Physician’s First Watch

 

4 – Recommended Immunization Schedule for Children and Adolescents Aged 18 Years or Younger, UNITED STATES, 2017 – Centers for Disease Control and Prevention

 

5 – Recommended Childhood and Adolescent Immunization Schedule—United States, 2017 – Pediatrics

 

6 – Prevention of contrast-induced acute kidney injury in patients undergoing cardiovascular procedures-a systematic review and network meta-analysis – PLoS One

 

7 – Nicotine, Carcinogen, and Toxin Exposure in Long-Term E-Cigarette and Nicotine Replacement Therapy Users: A Cross-sectional Study – Annals of Internal Medicine (link to abstract – $ required for full-text)

Sources: Medscape – E-Cigarettes as Safe as Nicotine Replacement in Real-World Study (free registration required) And Study of cancer-causing toxins finds e-cigs much safer than smoking – Reuters And Study: E-Cig Use Safer than Smoking? Toxic exposures much lower in biomarker analysis – MedPage Today (free registration required)

 

8 – Dengue: knowledge gaps, unmet needs, and research priorities – The Lancet Infectious Diseases (free registration required) (RT @Onisillos)

 

9 – Prevention and control of dengue—the light at the end of the tunnel – The Lancet Infectious Diseases (free registration required) (RT @Onisillos)

 

10 – Disease and economic burdens of dengue – The Lancet Infectious Diseases (free registration required) (RT @Onisillos)

 

Tue, Feb 7 – Top 10 Medical News Stories

7Feb
2017

 

1 – Comparative Effectiveness of Vancomycin and Metronidazole for the Prevention of Recurrence and Death in Patients With Clostridium difficile Infection – JAMA Internal Medicine (RT @PreetiNMalani)

Among patients with severe infections, those treated with vancomycin had a lower risk of death than patients treated with metronidazole

 

2 – Top Preventive Services Recommendations Ranked by Relative Efficacy – Annals of Family Medicine Research (RT @aafp and @juliekwoodmd)

 

3 – Updated Priorities Among Effective Clinical Preventive Services – Annals of Family Medicine 

Priorities for Improving Utilization of Clinical Preventive Services. Top 5 are: 1) Childhood immunization; 2) Brief prevention counseling for tobacco use in youth; 3) Tobacco use screening and brief counseling for adults; 4) Alcohol misuse screening and brief intervention; and 5) Aspirin chemoprevention for those at higher risk of CVD.

 

4 – Richard Lehman’s journal review-6 February 2017 – The BMJ Blog Archive

 

5 – International Day of Zero Tolerance to Female Genital Mutilation – UN Women

See also WHO guidelines on the management of health complications from female genital mutilation – World Health Organization And New WHO guidelines to improve care for millions living with female genital mutilation – World Health Organization

 

6 – Impact of weight maintenance and loss on diabetes risk and burden: a population-based study in 33,184 participants – BMC Public Health

 

7 – Study highlights importance of preventing weight gain in adults to reduce type 2 diabetes – EurekaAlert!

 

8 – Preventative medicine: the argument for and against – The Conversation

 

9 – Editorial: Health in slums: understanding the unseen – The Lancet

See also from previous weeks: The history, geography, and sociology of slums and the health problems of people who live in slums – The Lancet (free registration required) And Improving the health and welfare of people who live in slums – The Lancet (free registration required)

 

10 – Exercise management in type 1 diabetes: a consensus statement – The Lancet Diabetes & Endocrinology (free registration required)

Source: PracticeUpdate – Exercise Management in Type 1 Diabetes: A Consensus Statement (free resource to find articles of interest in all specialties – registration required)

 

Mon, Feb 6 – Top 10 Medical News Stories

6Feb
2017

 

1 – #WorldCancerDay 2017 (4 February) – World Health Organization

 

2 – #WorldCancerDay 2017 (4 February) – Guide to Cancer Early Diagnosis – World Health Organization

News release: Early cancer diagnosis saves lives, cuts treatment costs

 

3 – #WorldCancerDay 2017 (4 February) – Cancer: Fact sheet – World Health Organization

 

4 – Cerebral Palsy in Under 25s: Assessment and Management – National Institute for Health and Care Excellence (NICE)

 

5 – Acute Respiratory Infection and Use of Nonsteroidal Anti-Inflammatory Drugs on Risk of Acute Myocardial Infarction: A Nationwide Case-Crossover Study – The Journal of Infectious Diseases

Source: Medscape – NSAIDs Plus Respiratory Infection Increase Heart Attack Risk (free registration required)

“Nonsteroidal anti-inflammatory drug (NSAID) use during acute respiratory infection (ARI) increases the risk for acute myocardial infarction (AMI) 3.4-fold if taken by mouth and 7.2-fold with parenteral dosing”

 

6 – High-altitude living decreases the risk of heart disease – ScieceDaily

 

7 – Stinging insect hypersensitivity: A practice parameter update – American Academy of Allergy, Asthma & Immunology; American College of Allergy, Asthma & Immunology

Source: NEJM Journal Watch – Recommendations for Managing Stinging Insect Reactions ($ resource to find articles of interest in all specialties)

 

8 – Alpha blockers in the management of ureteric lithiasis: A meta-analysis – International Journal of Clinical Practice

Source: EvidenceAlerts (free resource to find articles of interest in all specialties – registration required)

Stone expulsion time was in average 3.99 days shorter with α-blockers with greater benefit for stones > 5 mm

 

9 – Folic Acid Supplementation for the Prevention of Neural Tube Defects: US Preventive Services Task Force Recommendation Statement – JAMA

Source: EvidenceAlerts (free resource to find articles of interest in all specialties – registration required)

 

10 – The Effects of Pay-for-Performance Programs on Health, Health Care Use, and Processes of Care: A Systematic Review – Annals of Internal Medicine

 

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