Open access

Fri, October 20 – 10 Stories of The Day!



1 – Levels & Trends in Child Mortality – UNICEF (free PDF)

News release: Levels and Trends in Child Mortality (free)

Commentaries: 7,000 newborns die every day, despite steady decrease in under-five mortality, new report says – The World Bank (free) AND New child mortality estimates show that 15,000 children died every day in 2016 – The World Bank (free) AND Unconscionable': 7,000 babies die daily despite record low for child mortality – The Guardian (free)


2 – Report: The Lancet Commission on pollution and health (Report, Executive Summary, Video, Audio and Comments – free registration required)

Commentaries: Report: Pollution Kills 3 Times More than AIDS, TB And Malaria Combined – NPR (free) AND Pollution linked to one in six deaths – BBC (free)


3 – 2017 Infectious Diseases Society of America Clinical Practice Guidelines for the Diagnosis and Management of Infectious Diarrhea (free)

Commentary: New diarrhea guidelines stress implications of molecular tests – CIDRAP (free)


4 – Right heart dysfunction and failure in heart failure with preserved ejection fraction: mechanisms and management. Position statement on behalf of the Heart Failure Association of the European Society of Cardiology (free)


5 – Elevated blood pressure and risk of mitral regurgitation: A longitudinal cohort study of 5.5 million United Kingdom adults – PLOS Medicine (free)

Commentaries: High Blood Pressure Is a Risk Factor For Mitral Regurgitation – Medical Research (free) AND High Blood Pressure May Raise Mitral Regurgitation Risk – TCTMD (free) AND Inevitable or preventable? High blood pressure linked to mitral regurgitation – Cardiovascular Business (free)


6 – High-flow oxygen via nasal cannulae in patients with acute hypoxemic respiratory failure: a systematic review and meta-analysis – Systematic Reviews (free)

“In patients with acute hypoxemic respiratory failure HFNC was not associated with a difference in mortality compared to Noninvasive ventilation or standard oxygen”


7 – Imaging Studies Offer New Insights Into Inflammation In CV Disease – Cardiobrief (free)

Original article: Colchicine Therapy and Plaque Stabilization in Patients With Acute Coronary Syndrome – Journal of The American College of Cardiology (link to abstract – $ for full-text)

“Preliminary evidence that colchicine may reduce coronary plaque”.


8 – Evidence-based guidelines for supportive care of patients with Ebola virus disease – The Lancet (free)

Commentaries: New Ebola guidelines address immediate supportive care – CIDRAP (free)


9 – Update: Interim Guidance for the Diagnosis, Evaluation, and Management of Infants with Possible Congenital Zika Virus Infection – MMWR / CDC (free)

Commentaries: CDC Offers New Guidance on Diagnosing and Managing Zika in Infants – Physician’s First Watch (free)


10 – A Highly Pathogenic Avian H7N9 Influenza Virus Isolated from A Human Is Lethal in Some Ferrets Infected via Respiratory Droplets – Cell Host Microbe (free)

Commentaries: H7N9 study finds virus poised to become more lethal, resistant to treatment – CIDRAP (free) AND H7N9 influenza is both lethal and transmissible in animal model for flu – University of Wisconsin–Madison (free) AND Will the World’s Most Worrying Flu Virus Go Pandemic? – The Atlantic (free)


Thu, October 19 – 10 Stories of The Day!



1 – 2017 ACC Expert Consensus Decision Pathway on the Management of Mitral Regurgitation – Journal of The American College of Cardiology (free)

Commentaries: Expert Consensus Decision Pathway for Management of Mitral Regurgitation – American College of Cardiology, Latest in Cardiology (free) AND ACC Recommends ‘Structured Approach’ to Mitral Regurgitation – MedPage Today (free registration required)


2 – Update to Practice Standards for Electrocardiographic Monitoring in Hospital Settings: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentaries: 12 key points to remember: Standards for Inpatient Electrocardiographic Monitoring – American College of Cardiology, Latest in Cardiology (free) AND AHA updates practice standards for electrocardiographic monitoring – ACP Hospitalist (free)


3 – Dark chocolate is now a health food. Here’s how that happened – VOX (free)

Related: Chocolate health: advice by Thomas Lüscher and peer review by Jonas Malmstedt – For Better Science (by @schneiderleonid)

“Big Chocolate’s investment in health science was a marketing masterstroke…” Interesting tale by @juliaoftoronto (RT @hildabast see Tweet)


4 – Long-term antibiotics likely to reduce risk of recurrent cellulitis – NIHR Signal (free)

Original article: Interventions for the prevention of recurrent erysipelas and cellulitis – Cochrane Library (link to abstract – $ for full-text)


5 – Comparing the Outcomes of Adults With Enterobacteriaceae Bacteremia Receiving Short-Course Versus Prolonged-Course Antibiotic Therapy in a Multicenter, Propensity Score–Matched Cohort – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentary: Short course of antibiotics worked as well as long for Enterobacteriaceae bacteremia – ACP Hospitalist (free)


6 – Report: Opportunities for Organ Donor Intervention Research: Saving Lives by Improving the Quality and Quantity of Organs for Transplantation (2017) – National Academies Press (free PDF)

Related Viewpoint: Organ Donor Research: Overcoming Challenges, Increasing Opportunities – JAMA (free)


7 – Short and Long Term Complications of In Utero Exposure to Lamotrigine – British Journal of Clinical Pharmacology (free PDF)

News release: Study Finds Epilepsy Drug to Be Safe During Pregnancy – Wiley (free)

Source: Study finds lamotrigine to be safe during pregnancy – The BMJ Research News ($)


8 – Richard Lehman’s journal review, 17 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


9 – Association of Patient Frailty With Increased Morbidity After Common Ambulatory General Surgery Operations – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Frailty Associated With Increased Risk of Complications Following Common, Outpatient Operations – The JAMA Network (free) AND Frailty tied to higher risk of complications with common surgeries – Reuters (free) AND Frailty linked to higher rate of perioperative morbidity – OnMedica (free)


10 – 25-Year Physical Activity Trajectories and Development of Subclinical Coronary Artery Disease as Measured by Coronary Artery Calcium – Mayo Clinic Proceedings (free)

Commentaries: Excessive Exercise May Harm The Heart, Study Suggests – Forbes (free) AND Physically active white men at high risk for plaque buildup in arteries – ScienceDaily (free)


Wed, October 18 – 10 Stories of The Day!



1 – Guideline: 2017 Appropriate Use Criteria for the Treatment of Patients With Severe Aortic Stenosis (free)

Commentaries: 2017 AUC for Management of Severe Aortic Stenosis – American College of Cardiology, Latest in Cardiology (free) AND First Appropriate Use Criteria Issued for Severe Aortic Stenosis – Medpage Today (free registration required)


2 – Association of Blood Transfusion From Female Donors With and Without a History of Pregnancy With Mortality Among Male and Female Transfusion Recipients – JAMA (link to abstract – $ for full-text)

Commentaries: Blood Boundaries: Should Transfusions Be Matched by Sex? – Scientific American (free) AND Are transfusions harmful to men if the blood comes from women who have been pregnant? – STAT (free) AND Receipt of Blood Transfusion From Previously Pregnant Donor Associated with Increased Risk of Death Among Male Recipients – The JAMA Network (free)


3 – Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free)

Antibiotic-associated diarrhea ocurred in 8.0% of the probiotic group compared to 17.7% in the control group. The number needed to treat (NNT) to prevent one case of diarrhea was 11 (95% CI 6 to 13).


4 – Approach to recurrent fever in childhood – Canadian medical Association Journal (free)


5 – Comparative safety of direct oral anticoagulants and warfarin in venous thromboembolism: multicentre, population based, observational study – The BMJ (free)

Commentary: New Anticoagulants Not Linked To Excess Bleeding Rates – Cardiobrief (free)


6 – How Low to Go With Glucose, Cholesterol, and Blood Pressure in Primary Prevention of CVD – Journal of The American College of Cardiology (free)

Summary with 12 key points to remember: Glucose, Cholesterol, BP Targets for CVD Risk Factors – American College of Cardiology, Latest in Cardiology (free)


7 – Omega-6 fatty acid biomarkers and incident type 2 diabetes: pooled analysis of individual-level data for 39 740 adults from 20 prospective cohort studies – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: Omega-6 fats may help prevent type 2 diabetes – George Institute for Global Health (free) AND Eating More Nuts Could Protect Against Type 2 Diabetes – Medscape (free registration required) AND Omega-6 could lower type 2 diabetes risk by 35 percent – Medical News Today (free)


8 – The oncologic burden of hepatitis C virus infection: A clinical perspective – CA: A Cancer Journal for Clinicians (free)


9 – Recommendations for Prevention and Control of Influenza in Children, 2017 – 2018 – American Academy of Pediatrics (free)

Commentary: 2017-2018 recommendations for pediatric influenza vaccination – Clinical Advisor (free) AND Fall Weather Headed Your Way? Time For Flu Shots – NPR (free)


10 – Individual support of nurses using electronic medicine monitors can improve HIV treatment – NIHR Signal (free)

Original article: Effectiveness and cost-effectiveness of a nurse-delivered intervention to improve adherence to treatment for HIV: a pragmatic, multicentre, open-label, randomised clinical trial – The Lancet Infectious Diseases (free)


Tue, October 17 – 10 Stories of The Day!



1 – Association of History of Gestational Diabetes With Long-term Cardiovascular Disease Risk in a Large Prospective Cohort of US Women – JAMA Internal Medicine (free)

Commentaries: CVD Risk for Women Rises After Gestational Diabetes – TCTMD (free) AND Does Gestational Diabetes Per Se Up Long-Term Cardiovascular Risk? – Medscape (free registration required) AND Gestational Diabetes Raises Heart Attack, Stroke Risk, NIH Study Finds – AJMC (free)


2 – Association of Antidepressant Medications With Incident Type 2 Diabetes Among Medicaid-Insured Youths – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Antidepressant Use in Youth Tied to Increased Diabetes Risk – Physician’s First Watch (free)

Related article: The risk of new-onset diabetes in antidepressant users – A systematic review and meta-analysis – PLOS One (free) AND Commentary: Type 2 Diabetes and Antidepressant Drug Use: Is There a Causal Link? – Endocrinology Advisor (free)


3 – State of The Art Review: Why and how to step down chronic asthma drugs – The BMJ (free)


4 – Clinical Use of a Home Sleep Apnea Test: An American Academy of Sleep Medicine Position Statement (free)

News release: AASM releases position statement on home sleep apnea testing (free)

Commentaries: AASM: Position Statement on Home Sleep Apnea Testing – MPR (free) AND Sleep Medicine Academy Releases Statements on Home Apnea Testing – Physician’s First Watch (free)


5 – Sex Differences and Similarities in Atrial Fibrillation Epidemiology, Risk Factors, and Mortality in Community Cohorts: Results From the BiomarCaRE Consortium (Biomarker for Cardiovascular Risk Assessment in Europe) – Circulation (link to abstract – $ for full-text)

Commentaries: A-fib strikes men a decade earlier than women – Medical News Today (free) And AHA: Men develop AFib a decade before women do; BMI linked to increased risk – Cardiovascular Business (free)


6 – Modelled Cost-Effectiveness of a Package Size Cap and a Kilojoule Reduction Intervention to Reduce Energy Intake from Sugar-Sweetened Beverages in Australia – Nutrients (free)

Commentaries: Cutting sugar in soft drinks would save 155,000 lives and $8 billion: experts – The Age (free) AND Study spells out huge health benefits by cutting back sugar in sugary drinks – University of New South Wales, Sidney (free)


7 – We may soon have our first $1 million drug. Who will pay for it? And how? – STAT (free)


8 – Long-term Outcomes of Multiple Arterial Coronary Artery Bypass Grafting: A Population-Based Study of Patients in British Columbia, Canada – JAMA Cardiology (free)

Commentaries: Study: Triple-Vessel CABG Strategy Matters in the Long Run – MedPage Today (free registration required)

In patients with multivessel disease who are undergoing coronary artery bypass grafting, multiple arterial grafting (MAG) is associated with reduced mortality, repeated revascularization, myocardial infarction, and heart failure when compared with left internal thoracic artery (LITA) supplemented by saphenous vein grafts (LITA+SVG).


9 – 2017 EACTS/EACTA Guidelines on patient blood management for adult cardiac surgery (free)


10 – Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus – Nature Communications (free)

Commentaries: Proton pump inhibitors linked to liver disease, researchers find – The Pharmaceutical Journal (free) AND Liver disease risk may be heightened by gastric acid drugs – Medical News Today (free) AND Common acid reflux medications promote chronic liver disease – EurekAlert (free)


Mon, October 16 – 10 Stories of The Day!



1 – The Revised Declaration of Geneva: A Modern-Day Physician’s Pledge – JAMA (free)


2 – Alleviating the access abyss in palliative care and pain relief—an imperative of universal health coverage: the Lancet Commission report (free registration required)

Commentaries: A milestone for palliative care and pain relief – The Lancet (free registration required) AND Millions die suffering amid global opioid gap, report says – STAT (free) AND More than 25 million people dying in agony without morphine every year – The Guardian (free)


3 – Guideline: Assessing and managing children at primary health-care facilities to prevent overweight and obesity in the context of the double burden of malnutrition – World Health Organization (free) (RT @equitylist see Tweet)

News release: WHO releases guidelines to address overweight and obesity in children (free)

Related report: Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults – The Lancet (free) AND Commentaries: Tenfold increase in childhood and adolescent obesity in four decades: new study by Imperial College London and WHO – World Health Organization (free) Double-duty solutions for the double burden of malnutrition (free)


4 – Long Sleeves on Doctors’ White Coats May Spread Germs – Scientific American (free)

Related guideline: Healthcare Personnel Attire in Non-Operating-Room Settings – Infection Control and Hospital Epidemiology (free) AND Commentaries: Goodbye to the Doctor’s White Coat? – The New York Times (10 articles per month are free) AND New infection control recommendations could make white coats obsolete – ScienceDaily (free) AND Should Doctors Still Be Allowed to Wear White Coats? You Decide – HIV and ID Observations (free)


5 – Draft Recommendation Statement: Skin Cancer Prevention: Behavioral Counseling – U.S. Preventive Services Task Force (free)

Commentary: USPSTF Draft Statement Recommends Sun-Safe Behavioral Counseling for More Fair-Skinned Youth – Physician’s First Watch (free)


6 – Blood pressure targets in people with cardiovascular disease – Cochrane Library (free)


7 – Testing blood procalcitonin levels to decide when to start and stop antibiotics in adults with acute respiratory tract infections – Cochrane Library (free)

Original Article: Procalcitonin to initiate or discontinue antibiotics in acute respiratory tract infections – Cochrane Library (link to abstract – $ for full-text)

“the use of procalcitonin to guide initiation and duration of antibiotic treatment results in lower risks of mortality, lower antibiotic consumption, and lower risk for antibiotic-related side effects”.


8 – 2017 EACTS Guidelines on perioperative medication in adult cardiac surgery – European Journal of Cardio-Thoracic Surgery (free)

Source: Critical Care Reviews Newsletter (free)


9 – Antibiotic susceptibility testing in less than 30 min using direct single-cell imaging – Proceedings of the National Academy of Sciences (free)

Commentary: Rapid Test for Antibiotic Susceptibility – JAMA (free)


10 – Older people with acute coronary syndromes may benefit from routine invasive therapy – NIHR Signal (free)

Original article: Revascularisation compared with initial medical therapy for non-ST-elevation acute coronary syndromes in the elderly: a meta-analysis – Heart (link to abstract – $ for full-text)


Fri, October 13 – 10 Stories of The Day!



1 – Phase 2 Placebo-Controlled Trial of Two Vaccines to Prevent Ebola in Liberia – New England Journal of Medicine (free)

Editorial: Handle Survivors with Care (free)

Commentaries: Experimental Ebola vaccines elicit year-long immune response – NIH New Releases (free) AND Ebola Vaccines Elicit Immune Responses in Liberian Adults – Physician’s First Watch (free) AND Liberia trial finds Ebola vaccines yield year-long immune response – CIDRAP (free)


2 – Roadmap for zoonotic tuberculosis – Worl Health Organization (free)

WHO News release: TB partners launch first roadmap to jointly stop the transmission of bovine and zoonotic tuberculosis (free)


3 – Increasing prevalence of vascular risk factors in patients with stroke – Neurology (link to abstract – $ for full-text)

Commentary: Health Conditions That Increase Stroke Risk Rise Across All Ages, Races – NPR (free)

“An estimated 80% of all 1st strokes are due to risk factors that can be changed,” says new study (RT @ACCmediacenter see Tweet)


4 – Review: Management of cardiovascular diseases in patients with obesity – Nature Reviews Cardiology (free)


5 – Clinical Practice Guidelines for the Treatment of Rectal Prolapse – Diseases of the Colon & Rectum (free)


6 – Management of a Diabetic Foot – JAMA Clinical Guidelines Synopsis (free) (RT @adamcifu)

Original guideline: The management of diabetic foot: A clinical practice guideline by the Society for Vascular Surgery in collaboration with the American Podiatric Medical Association and the Society for Vascular Medicine (free)


7 – We Need to Talk About Kids and Smartphones – TIME (free)

Related: Have Smartphones Destroyed a Generation? – The Atlantic (free)

“Just how dangerous are smartphones for kids? Here’s why health experts are worried”


8 – Last Month in Oncology with Dr. Bishal Gyawali: September 2017 – eCancer News (free)


9 – Diagnostic and therapeutic treatment modalities for acute lower gastrointestinal bleeding: a systematic review – Endoscopy International Open (free)


10 – Iron absorption from oral iron supplements given on consecutive versus alternate days and as single morning doses versus twice-daily split dosing in iron-depleted women: two open-label, randomised controlled trials – The Lancet Haematology (free)

Commentaries: Treatment of iron deficiency is getting trendy – The Lancet Haematology (free) AND Taking Iron Every Other Day Linked to Better Absorption in Iron-Deficient Women – Physician’s First Watch (free)


Thu, October 12 – 10 Stories of The Day!



1 – The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free)

See also: Executive Summary (free)


2 – Diagnosis and Management of Noncardiac Complications in Adults With Congenital Heart Disease: A Scientific Statement From the American Heart Association (free)

News release: Looking beyond the heart in adults with congenital heart disease (free)

Commentary: Think Outside the Heart: Noncardiac Complications and Considerations in the Adult Congenital Patient (free)

Top Ten Things to Know: Diagnosis and Management of Noncardiac Complications in Adults with Congenital Heart Disease (free PDF)


3 – Social Determinants of Health 101 for Health Care: Five Plus Five – National Academy of Medicine (free)

See also: About social determinants of health – World Health Organization (free) AND WHO’s work on SDoH (free resources)


4 – Relative age within the school year and diagnosis of attention-deficit hyperactivity disorder: a nationwide population-based study – The Lancet Psychiatry (free)

Commentaries: The role of schools in the diagnosis of ADHD – The Lancet Psychiatry (free) AND ‘Relative’ school age biases ADHD diagnosis – OnMedica (free) AND Youngest children in school year ‘more likely’ to get ADHD diagnosis – NHS Choices (free)


5 – Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age – JAMA (free)

Commentaries: Ovarian reserve tests aren’t a good predictor of fertility, study finds – STAT (free) AND Tests Thought To Predict Future Fertility May Be Overused – Forbes (free) AND Fertility MOT tests ‘a waste of money’ – BBC News (free) AND Biomarkers Indicating Diminished Reserve of Eggs not Associated with Reduced Fertility – The JAMA Network (free)


6 – Meet the nocebo effect, the placebo effect’s evil twin that makes you feel pain – VOX (free)


7 – Comparison of postoperative outcomes among patients treated by male and female surgeons: a population based matched cohort study – The BMJ (free)

Editorial: Improving patient outcomes after surgery (free)

Commentaries: Female Surgeons Hold Slight Edge Over Male Peers in Terms of Patients’ 30-Day Mortality – TCTMD (free) AND Do Patients Have Better Survival with Female Surgeons? – MedPage Today (free registration required)


8 – Is child vaccination boosted by educating mothers? – BBC News (free)


9 – Contribution of dietary intake to relapse rate in early paediatric multiple sclerosis – Journal of Neurology, Neurosurgery & Psychiatry article (link to abstract – $ for full-text)

Commentaries: Fatty diets may boost relapse risk in MS children – OnMedica (free) AND High Fat Intake Linked to Risk for MS Relapse in Kids – Physician’s First Watch (free)


10 – Association of Insulin Pump Therapy vs Insulin Injection Therapy With Severe Hypoglycemia, Ketoacidosis, and Glycemic Control Among Children, Adolescents, and Young Adults With Type 1 Diabetes – JAMA (link to abstract – $ for full-text)

Commentaries: Insulin Pumps Associated With Lower Risk of Serious Complications among Young Patients with Type 1 Diabetes – The JAMA Network (free) AND Insulin-Pump Use Benefits Young People With Type 1 Diabetes – Medscape (free registration required) AND Can insulin pumps work better than injections for kids with diabetes? – Reuters (free)


Wed, October 11 – 10 Stories of The Day!



1 – Today is #WorldObesityDay: Tenfold increase in childhood and adolescent obesity in four decades: new study by Imperial College London and WHO – World Health Organization (free)

Original article: Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults – The Lancet (free) AND Invited Commentary: Double-duty solutions for the double burden of malnutrition (free)

Related report: Ending Childhood Obesity Implementation Plan: executive summary – World Health Organization (free PDF)


2 – #WorldObesityDay – Global cost of obesity-related illness to hit $1.2tn a year from 2025 – The Guardian (free)

See related Global Burden of Disease Study: Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free), Editorial: Global Health Effects of Overweight and Obesity (free) AND Commentary: New study finds more than 2 billion people overweight or obese – Institute for Health Metrics and Evaluation (free) 


3 – #WorldObesityDay – Meta-analysis on shift work and risks of specific obesity types – Obesity Reviews (link to abstract – $ for full-text)

Commentaries: Meta-Analysis Links Night Shift to Obesity Risk, Especially “Belly Fat” – AJMC (free) AND Night Shift Work Linked To Increased Risk of Obesity – Medical Research (free) AND Shift Work Increases Risk of Apple-Shaped Overweight/Obesity – Medscape (free registration required) AND Night shift work linked to an increased risk of obesity – Wiley, via EurekAlert (free)


4 – Guidelines: The do’s, don’ts and don’t knows of direct observation of clinical skills in medical education – Perspectives on Medical Education (free) (RT @brhospitalist and @CvanderVleuten see Tweet)


5 – Opinion: Updating Wikipedia should be part of all doctors’ jobs – STAT (free) (RT @Onisillos)


6 – Candida auris Clinical Update – September 2017 – Centers for Disease Control and Prevention (free)

Commentary: CDC Updates Guidance as Candida auris Cases Grow – Medscape (free registration required)

Related: Candida auris: A rapidly emerging cause of hospital-acquired multidrug-resistant fungal infections globally – PLOS Pathogens (free) AND A ‘perfect storm’ superbug: How an invasive fungus got health officials’ attention – STAT (free) AND CDC keeping a watchful eye on Candida auris – CIDRAP (free) AND CDC reports uptick in Candida auris cases – CIDRAP (free)


7 – Review: The Treatment of Illnesses Arising in Pregnancy – Deutsches Ärzteblatt international (free)


8 – Changes in marital quality over 6 years and its association with cardiovascular disease risk factors in men: findings from the ALSPAC prospective cohort study – Journal of Epidemiology & Community Health (free)

Commentaries: Marital ups and downs affect heart health – OnMedica (free) AND Marital ups and downs may impact men’s heart health – Medical News Today (free) AND Cardiovascular risk factors for married men linked to changes in relationship quality over time – News Medical (free)


9 – Gabapentin, opioids, and the risk of opioid-related death: A population-based nested case–control study – PLOS Medicine (free)

Commentaries: Gabapentin, Opioid Combo May Up the Risk of Opioid-Related Death – MPR (free) AND Gabapentin Plus Opioids a Deadly Combination? – MPR (free)


10 – Oral morphine versus ibuprofen administered at home for postoperative orthopedic pain in children: a randomized controlled trial – Canadian Medical Association Journal (free)

Commentaries: Ibuprofen Better Than Morphine After Minor Surgery in Kids – Medscape (free registration required) AND Ibuprofen better choice over oral morphine for pain relief in children after minor surgery – MedicalXpress (free)


Tue, October 10 – 10 Stories of The Day!



1 – Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold – CHEST Expert Panel Report (free)

See also other recent CHEST guidelines on the management of cough in specific populationsChronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough: CHEST Guideline and Expert Panel Report (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis: CHEST Guideline and Expert Panel Report (free)


2 – New NICE Guidelines on Guild Abuse, Neglect and Maltreatment

– Child abuse and neglect – National Institute for Health and Care Excellence (free)

– Child maltreatment: when to suspect maltreatment in under 18s – National Institute for Health and Care Excellence (free)

News release: Responding to child abuse and neglect – a view from NICE (free)


3 – Vitamin D supplementation to prevent asthma exacerbations: a systematic review and meta-analysis of individual participant data – The Lancet Respiratory Medicine (free)

Commentaries: Vitamin D and asthma: a case to answer – The Lancet Respiratory Medicine (free) AND Vitamin D may prevent asthma worsening for some – NHS Choices (free)


4 – Upstream watershed condition predicts rural children’s health across 35 developing countries – Nature Communications (free)

Commentaries: Healthy watersheds help stem deadly childhood diseases downstream – WWF Global (free) AND Global kids study: More trees, less disease – University of Vermont (free) AND More trees help water sanitation, reduce child deaths: study – Reuters (free)


5 – Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Midday Light Therapy May Improve Depressive Symptoms in Patients With Bipolar Disorder – Psychiatric News Allert (free) AND Bright Light Therapy Improves Bipolar Depression – Medscape (free registration required)


6 – Predicting 30-Day Mortality for Patients With Acute Heart Failure in the Emergency Department: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Tool may help accurately predict 30-day mortality for emergency department patients with acute heart failure – 2 Minute Medicine (free) AND Simple tool accurately predicts 30-day mortality for patients with acute heart failure in the ER – MedicalXpress (free)



7 – The Painful Side Of Positive Health Care Marketing – NPR (free)

Related: I have cancer. This comic shows how much pressure I feel to be a hero – VOX (free) AND Why cancer is not a war, fight, or battle – CNN (free) AND He’s a Fighter – The Atlantic (free)


8 – Richard Lehman’s journal review, 9 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.


9 – Interventions to reduce harm in people who use tobacco. The latest Cochrane Evidence – Cochrane Tobbaco Edition (free summaries) (RT @CochraneUK see Tweet)

Comprehensive resource on evidence-based interventions to reduce tobacco related harm.


10 – Female sex, early-onset hypertension, and risk of dementia – Neurology (link to abstract – $ for full-text)

Commentaries: For women, high blood pressure in your 40s may be tied to increased risk of Dementia – American Academy of Neurology, via ScienceDaily (free) AND Women’s dementia risk increased by midlife hypertension – Medical News Today (free) AND Mid-adulthood hypertension linked to dementia risk in women – Clinical Advisor (free)

Related Study: Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort – JAMA Neurology (link to abstract – $ for full-text) AND Commentaries: Midlife cardiovascular risk factors may increase chances of dementia – NIH News Releases (free) AND Midlife smoking, diabetes, and hypertension associated with late life dementia – 2 Minute Medicine (free) AND Heart disease risk in middle age tied to dementia later – Reuters (free)


Mon, October 9 – 10 Stories of The Day!



1 – Study links dental antibiotics to C diff cases – CIDRAP (free) AND Antibiotics for dental procedures linked to superbug infection – Infectious Diseases Society of America, via ScienceDaily (free)

Study Presented at #IDWeek2017


2 – Women who get frequent UTIs may reduce risk by drinking plenty of water – Infectious Diseases Society of America, via ScienceDaily (free) AND Recurrent Cystitis? Drink More Water – MedPage Today (free registration required) AND Drinking More Water Really Does Ward Off UTIs – LiveScience (free)

Study Presented at #IDWeek2017


3 – Efficacy and safety of switching from boosted protease inhibitors plus emtricitabine and tenofovir disoproxil fumarate regimens to single-tablet darunavir, cobicistat, emtricitabine, and tenofovir alafenamide at 48 weeks in adults with virologically suppressed HIV-1 (EMERALD): a phase 3, randomised, non-inferiority trial – The Lancet HIV (free)

Commentaries: Towards a universal second-line fixed-dose combination ART – The Lancet HIV (free) AND Single-Tablet ART: New Hope in HIV Therapy? All-in-one fixed dose combo proves safe, effective in EMERALD trial – MedPage Today (free registration required) AND EMERALD Trial: Week 48 Results Demonstrate Efficacy in Single-Tablet HIV Therapy – Infectious Diseases Advisor (free)

Study Presented at #IDWeek2017


4 – How Smartphones Hijack Our Minds – The Wall Street Journal (free) (RT @EricTopol see Tweet)

“Research suggests that as the brain grows dependent on phone technology, the intellect weakens”


5 – Impact of the Commercialization of Three Generic Angiotensin II Receptor Blockers on Adverse Events in Quebec, Canada: A Population-Based Time Series Analysis – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Generic Blood Pressure Drugs May Be Tied to Increase in Adverse Events – Physician’s First Watch (free) AND Generic ARBs Linked to Increased Adverse Events – TCTMD (free)

As in any observational study, association does not necessarily imply causation.


6 – Anticoagulant Use and Risk of Ischemic Stroke and Bleeding in Patients With Secondary Atrial Fibrillation Associated With Acute Coronary Syndromes, Acute Pulmonary Disease, or Sepsis – JACC: Clinical Electrophysiology (link to abstract – $ for full-text)

Commentaries: Anticoagulation didn’t benefit patients with afib secondary to ACS, pulmonary disease, or sepsis – ACP Hospitalist (free) AND No Anticoagulation Benefit, High Bleeding Risk Seen in Patients With Secondary A-fib – TCTMD (free)


7 – Serum Calcium and Risk of Sudden Cardiac Arrest in the General Population – Mayo Clinic Proceedings (link to abstract – $ for full-text)

Commentaries: Low serum calcium may increase risk of sudden cardiac arrest – EurekAlert (free) AND Low calcium may raise cardiac arrest risk by twofold – Medical News Today (free)


8 – Impact of the US Maternal Tetanus, Diphtheria, and Acellular Pertussis Vaccination Program on Preventing Pertussis in Infants <2 Months of Age: A Case-Control Evaluation – Clinical Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Study: Tdap vaccine in pregnancy protects infants – CIDRAP (free) AND Fewer newborns get whooping cough when moms get vaccinated – Reuters (free)


9 – Pharmacologically controlled drinking in the treatment of alcohol dependence or alcohol use disorders: a systematic review with direct and network meta-analyses on nalmefene, naltrexone, acamprosate, baclofen and topiramate – Addiction (link to abstract – $ for full-text) checar acesso

Commentary: Pills prescribed for alcoholism might not work, study finds – The Guardian (free)


10 – ‘Antibiotic apocalypse’: doctors sound alarm over drug resistance – The Guardian (free)

Related WHO Reports: Antibacterial Agents in Clinical Development (free) AND Global priority list of antibiotic-resistant bacteria to guide research, discovery, and development of new antibiotics (free) AND Commentary: WHO report paints dire picture of antibiotic development – CIDRAP (free)


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