TOP 10 Medical News Stories

Tue July 23 – 10 Stories of The Day!

23 Jul, 2019 | 09:52h | UTC


1 – WHO recommends dolutegravir as preferred HIV treatment option in all populations – World Health Organization (free)


2 – WHO recommendations for international traffic related to the Ebola Virus Disease outbreak in the Democratic Republic of the Congo – World Health Organization (free)

Commentary: The evidence on travel bans for diseases like Ebola is clear: they don’t work – Vox (free)

Related: WHO Declares New Ebola Outbreak a Public Health Emergency of International Concern (free statement and commentaries)


3 – Clinical practice guideline on peri- and postoperative care of arteriovenous fistulas and grafts for haemodialysis in adults – Nephrology Dialysis Transplantation (free)


4 – Guideline on diagnostic procedures for suspected hypersensitivity to beta-lactam antibiotics – Allergo Journal International (free)


5 – Wilderness Medical Society Practice Guidelines for the Prevention and Treatment of Frostbite: 2019 Update – Wilderness and Environmental Medicine (free)


6 – Recent trends in the age at diagnosis of colorectal cancer in the US National Cancer Data Base, 2004‐2015 – Cancer (link to abstract – $ for full-text)

Commentaries: Colon cancer cases rising among adults under 50 – UPI (free) AND More colorectal cancer cases are being diagnosed in younger patients – Wiley (free)

Related Studies: Another Study Shows Increased Incidence of Colorectal Cancer in Adults Aged 40 Through 49 Years (link to abstract and commentaries) AND Two Studies Point to Increase in Colorectal Cancer Incidence in Young Adults (link to abstract and commentaries)


7 – Diagnosing the Onset of Menopause – JAMA (free for a limited period)

Clinical Review Audio: Diagnosing Menopause (free)


8 – Association Between Plant-Based Dietary Patterns and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Commentaries: Following a healthy plant-based diet may lower type 2 diabetes risk – JAMA Internal Medicine (free) Eating a plant-based diet might help prevent type 2 diabetes, study suggests – CNN (free) AND Healthy plant-based diets could reduce diabetes risk, study says – UPI (free) AND Expert reaction to study on the vegetarian diet and diabetes risk – Science Media Centre (free)


9 – Music versus midazolam during preoperative nerve block placements: a prospective randomized controlled study – Regional Anesthesia & Pain Medicine (link to abstract – $ for full-text)

Commentaries: Music may offer alternative to preoperative drug routinely used to calm nerves – BMJ (free) AND Music ‘calms nerves before surgery’ as well as sedative – BBC (free) AND Music could offer alternative to sedatives – OnMedica (free)


10 – Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort – JAMA Psychiatry (free for a limited period)

Editorial: The Architecture of Autism Spectrum Disorder Risk: What Do We Know, and Where Do We Go From Here? (free for a limited period)

Commentaries: Genetic factors are primary cause of autism, study finds – UPI (free) AND Study provides ‘strongest evidence’ yet for autism being a genetic condition – News Medical (free) AND A new study reinforces the conclusion that autism is primarily genetic – Science Based Medicine (free)


Mon July 22 – 10 Stories of The Day!

21 Jul, 2019 | 22:14h | UTC


1 – Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)

Summary: Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)

Related Meta-Analysis: Choice of Intravenous Crystalloid Fluid and Mortality in Critically Ill Adult Patients – Southern Medical Journal (link to abstract – $ for full-text)

Related Randomized Trials: Balanced Crystalloids vs Saline in Hospitalized Patients (free studies and commentary)

“The three ongoing studies once published and assessed may alter the conclusions of the review.”


2 – Cancer and heart disease: associations and relations – European Journal of Heart Failure (free)


3 – Antimicrobial Stewardship in Cancer Patients: The Time is Now – Journal of the National Comprehensive Cancer Network (free)


4 – Deep Learning to Assess Long-term Mortality from Chest Radiographs – JAMA Network Open (free)

Commentaries: Prediction and Prevention Using Deep Learning – JAMA Network Open (free) AND Chest X-rays contain information that can be harvested with AI – Massachusetts General Hospital (free)


5 – ESCMID-EUCIC clinical guidelines on decolonization of multidrug-resistant Gram-negative bacteria carriers – Clinical Microbiology and Infection (free)


6 – Distinguishing opinion from evidence in guidelines – The BMJ (free for a limited period)


7 – Evidence vs Consensus in Clinical Practice Guidelines – JAMA (free for a limited period)


8 – A bird’s-eye view of clinical trials provides new perspectives on drug research and development – STAT (free)


9 – Series: Oral Health – The Lancet (free articles and commentaries – registration required)


10 – Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentaries: Study Distinguishes Schizophrenia Drug Effects Among Patients – MD Magazine (free) AND New Guidance on Antipsychotic Choice – Medscape (free registration required)

“These findings will aid clinicians in balancing risks versus benefits of those drugs available in their countries. They should consider the importance of each outcome, the patients’ medical problems, and preferences.”


Fri July 19 – 10 Stories of The Day!

19 Jul, 2019 | 09:56h | UTC


1 – Canadian Association of Gastroenterology Clinical Practice Guideline for the Management of Luminal Crohn’s Disease – Journal of the Canadian Association of Gastroenterology (free)

Related Guidelines: Crohn’s disease: management – National Institute for Health and Care Excellence (free) AND ACG Clinical Guideline: Management of Crohn’s Disease in Adults – The American Journal of Gastroenterology (free)


2 – Management of Patients with Acute Ischemic Stroke – JAMA (free for a limited period)

Original Guideline: 2018 AHA/ASA Guidelines for the Early Management of Patients With Acute Ischemic Stroke (free)

Related Guidelines: Stroke and transient ischaemic attack in over 16s: diagnosis and initial management – National Institute for Health and Care Excellence (free) AND Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ (free) AND Canadian Stroke Best Practice Recommendations for Acute Stroke Management (free)


3 – Effect of Systolic and Diastolic Blood Pressure on Cardiovascular Outcomes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Hypertension From Top to Bottom: Don’t Ignore Diastolic BP – TCTMD (free) AND Both Systolic and Diastolic BP Affect CV Outcomes – NEJM Journal Watch (free)


4 – Incentives for smoking cessation – Cochrane Library (free)

Summaries: Can rewards help smokers to quit in the long term? – Cochrane Library (free) AND Featured Review: Incentives for smoking cessation – Cochrane Library (free)

Commentaries: Helping smokers quit: financial incentives work – The Conversation (free) AND NHS could save billions by offering cash reward to quit smoking – The Guardian (free)


5 – Association Between Electronic Cigarette Use and Smoking Reduction in France – JAMA Internal Medicine (free for a limited period)

Commentaries: No evidence that e-cigarettes help long-term smoking cessation – OnMedica (free) AND Study: E-cigarettes can help smokers quit, but have higher rate of relapse – UPI (free) AND Adults who vape are more likely to quit cigarettes, study finds – CNN (free)

Related Randomized Trial: E-Cigarettes vs. Nicotine-Replacement Therapy – New England Journal of Medicine (link to abstract and commentaries)

Related Guidelines and Reports: Public Health Consequences of E-Cigarettes – National Academies of Sciences, Engineering, and Medicine (free) AND E-cigarettes and heated tobacco products: evidence review – Public Health England (free) AND E-cigarettes: balancing risks and opportunities – British Medical Association (free PDF) AND Nicotine without smoke: Tobacco harm reduction – Royal College of Physicians(free summary and PDF)


6 – Perspective: The Promise and Price of Cellular Therapies – The New Yorker (a few articles per month are free)

“New “living drugs”—made from a patient’s own cells—can cure once incurable cancers. But can we afford them?”


7 – Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance – The Journal of Clinical Investigation (free)

Commentaries: Persistent HIV in central nervous system linked to cognitive impairment – NIH News Release (free) AND HIV-infected cells persist in cerebrospinal fluid, linked to poorer neurocognitive performance – University of North Carolina School of Medicine (free)


8 – Alex Nowbar’s journal reviews, 18 July 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.


9 – Anticoagulation in the cirrhotic patient – JHEP Reports (free)

Related: The Complex Role of Anticoagulation in Cirrhosis: An Updated Review of Where We Are and Where We Are Going – Digestion (free) AND Direct Oral Anticoagulants in Cirrhotic Patients: Current Evidence and Clinical Observations – Canadian Journal of Gastroenterology and Hepatology (free) AND Anticoagulation in cirrhosis: a new paradigm? – Clinical and Molecular Hepatology (free)


10 – Cardiovascular and Cerebrovascular Safety of Testosterone Replacement Therapy Among Aging Men with Low Testosterone Levels: A Cohort Study – American Journal of Medicine (link to abstract – $ for full-text)

Commentary: Testosterone replacement therapy (TRT) can increase men’s risk of stroke and heart attack – Elsevier (free)


Thu July 18 – 10 Stories of The Day!

18 Jul, 2019 | 11:18h | UTC


1 – News Release: Ebola outbreak in the Democratic Republic of the Congo declared a Public Health Emergency of International Concern – World Health Organization (free)

Commentaries: DR Congo Ebola outbreak now a Public Health Emergency, UN health agency declares – United Nations (free) AND WHO declares public health emergency over DRC Ebola – CIDRAP (free) AND WHO sounds Ebola alarm as risks intensify – Reuters (free) AND The WHO finally declared a public health emergency over Ebola – Vox (free)

See also: Statement by the Emergency Committee (free PDF)

Related: Special Report: The Ongoing Ebola Epidemic in the Democratic Republic of Congo, 2018–2019 – New England Journal of Medicine (free) AND Comprehensive Review: Ebola virus disease – The Lancet (free)


2 – Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis – The BMJ (free)

Editorial: Preventable harm: getting the measure right (free)

Commentaries: One in 20 patients exposed to preventable harm in medical care – OnMedica (free) AND Half of All Patient Harms ‘Preventable’ – Medscape (free registration required)


3 – Impact of community based screening for hypertension on blood pressure after two years: regression discontinuity analysis in a national cohort of older adults in China – The BMJ (free)

Commentary: The power of awareness – The BMJ Opinion (free)


4 – The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial – The Lancet (free)

Invited Commentary: Partial versus total knee replacement for knee osteoarthritis – The Lancet (free)


5 – Original Studies: Universal Testing, Expanded Treatment, and Incidence of HIV Infection in Botswana – New England Journal of Medicine (free) AND Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART) – New England Journal of Medicine (free) AND HIV Testing and Treatment with the Use of a Community Health Approach in Rural Africa – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Intensive Anti-H.I.V. Efforts Meet With Mixed Success in Africa – The New York Times (10 articles per month are free) AND HIV Incidence: Effect of Universal Testing and Treatment – (free) AND New HIV program increased viral suppression, decreased new infections in Botswana – Harvard T.H. Chan School of Public Health (free)


6 – Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry – Journal of the American Heart Association (free)

Editorial: Is Transient Takotsubo Syndrome Associated With Cancer? Why, and With What Implications for Oncocardiology? (free)

Commentary: Cancer Rates High in Patients with Takotsubo Syndrome – NEJM Journal Watch (free)


7 – Menstrual cup use, leakage, acceptability, safety, and availability: a systematic review and meta-analysis – The Lancet Public Health (free)

Commentaries: Inserting informed choice into global menstrual product use and provision – The Lancet Public Health (free) AND Menstrual Cups: Study Finds They’re Safe To Use — And People Like Them – NPR (free) AND Menstrual cups ‘as reliable as tampons’ – BBC (free) AND A Better Way to Manage Your Period? Try the Menstrual Cup, Scientists Say – The New York Times (free)


8 – Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging – JAMA Neurology (free for a limited period)

Commentaries: Scientists close in on blood test for Alzheimer’s – STAT (free) AND Predicting Alzheimer’s – Blood markers close in on helping determine who will develop Alzheimer’s disease – MedPage Today (free registration required)

“What good will that do without a cure?” (from STAT)


9 – A multimodality test to guide the management of patients with a pancreatic cyst – Science Translational Medicine (link to abstract – $ for full-text)

Commentaries: Test shown to improve accuracy in identifying precancerous pancreatic cysts – Johns Hopkins Medicine (free) AND Machine Learning Guides Pancreatic Cyst Management in Patients – American Association for the Advancement of Science (free) AND An experimental AI system can predict when pancreatic cysts will become cancerous – STAT (free)


10 – The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness – The Lancet Psychiatry (free registration required)

Executive Summary and Podcast: A blueprint for protecting physical health in people with mental illness (free summary, audio and other resources)

Commentaries: Global commission into health inequities of mental illness gives blueprint for change – NICM Health Research Institute at Western Sydney University (free) AND People with mental illness experience poorer physical health, and the gap may be getting worse, experts say – ABC News (free) AND Why people with mental illness may face poorer physical health and early death – CNN (free)

Related WHO Guideline: Management of Physical Health Conditions in Adults with Severe Mental Disorders (free)


Wed July 17 – 10 Stories of The Day!

17 Jul, 2019 | 10:52h | UTC


1 – Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis – Stroke (free)

Source: EvidenceAlerts

“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.


2 – Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice – JAMA (free for a limited period)

Editorial: Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice (free for a limited period)

Video Summary: Association Between Time to Treatment With Endovascular Reperfusion Therapy and Acute Ischemic Stroke Outcomes (free)

News Release: Treating stroke patients just 15 minutes earlier can save lives – UCLA (free)


3 – Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis – JAMA (free for a limited period)

Editorial: Government Regulation of Sepsis Care (free for a limited period)

Commentaries: First Ever State Sepsis Regulation in U.S. Tied to Lower Death Rates – University of Pittsburg (free) AND Regulations That Mandate Sepsis Care Appear To Have Worked In New York – NPR (free)


4 – Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Psychological Consequences of Admission to the ICU: Helping Patients and Families (free for a limited period)

Author Interview: Do Flexible Family Visitation Hours Reduce Delirium in ICU Patients? – (free)


5 – The prevention and management of sudden cardiac arrest in athletes – Canadian Medical Association Journal (free)

Commentary: Sudden cardiac arrest in athletes: Prevention and management – Joule Inc. (free)


6 – Editorial: Lithium as the drug of choice for maintenance treatment in bipolar disorder – Acta Psychiatrica Scandinavica (free) (via @J_F_Hayes)

Original Article: A systematic review and meta‐analysis of clinical predictors of lithium response in bipolar disorder – Acta Psychiatrica Scandinavica (free)


7 – Editorial: The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms – JAMA Neurology (free for a limited period)

Original Article: Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework – JAMA Neurology (free)


8 – Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing – Korean Journal of Family Medicine (free PDF)

“individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.”


9 – Post‐intensive care syndrome: its pathophysiology, prevention, and future directions – Acute Medicine & Surgery (free) (via @NydahlPeter)

Related Reviews: Post-intensive care outpatient clinic: is it feasible and effective? A literature review – Revista Brasileira de Medicina Intensiva (free) AND Post-intensive Care Syndrome: an Overview – Journal of Translational Internal Medicine (free) AND Optimizing Post-Intensive Care Unit Rehabilitation – Turkish Thoracic Journal (free)


10 – Update on acetylsalicylic acid for primary prevention of cardiovascular disease: Not initiating is not the same thing as discontinuing – Canadian Family Physician (free)

See also: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free)

Related: A Practical Approach to Low-Dose Aspirin for Primary Prevention (free) AND Aspirin for Primary Prevention: Is This the End of the Road? (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free)


Tue July 16 – 10 Stories of The Day!

16 Jul, 2019 | 09:53h | UTC


1 – Healing the Professional Culture of Medicine – Mayo Clinic Proceedings (free)

Related: Understanding organisational culture for healthcare quality improvement – The BMJ (free)


2 – State of The Art Review: Pre-eclampsia: pathophysiology and clinical implications – The BMJ (free for a limited period)


3 – Association of residency work hour reform with long term quality and costs of care of US physicians: observational study – The BMJ (free)

Commentaries: Reduced work hours for trainee doctors not seen to compromise care – Reuters (free) AND Capping medical residency hours does not hamper new doctors’ quality of training – Harvard Medical School (free) AND Is an 80-Hour Workweek Enough to Train a Doctor? – Harvard Business Review (free)


4 – Risks of stillbirth and neonatal death with advancing gestation at term: A systematic review and meta-analysis of cohort studies of 15 million pregnancies – PLOS Medicine (free)

Commentaries: New stillbirth risk figures help women’s decisions on timing delivery – Queen Mary University of London (free) AND Higher risk of stillbirth in longer pregnancies, study finds – PLOS (free) AND Expert reaction to study on longer pregnancies and risk of stillbirth – Science Media Centre (free)

Related Cochrane Review: Induction of Labor for Improving Birth Outcomes for Women at or Beyond Term (free)

Related Randomized Trials: Labor Induction vs. Expectant Management in Low-Risk Nulliparous Women (free) AND Induction of Labor at 41 Weeks vs. Expectant Management Until 42 Weeks (free)

Related WHO Recommendations: Induction of Labor at or Beyond Term (free)


5 – Hartmann’s procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Farewell to Hartmann’s Procedure? – MedPage Today (free registration required)


6 – Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Non-vitamin K oral anticoagulants appear superior to vitamin K antagonists in early-stage CKD – ACP Internist (free) AND Evidence Favors NOACs for Anticoagulation in Early Chronic Kidney Disease – NEJM Journal Watch (free)


7 – Association of Lifestyle and Genetic Risk With Incidence of Dementia – JAMA (free for a limited period)

Commentaries: Healthy lifestyle reduces dementia risk even in those with genetic risk factors – NHS Choices (free) AND Healthy lifestyle may offset genetic risk of dementia – University of Exeter (free) AND Genes vs. lifestyle: Study ‘undermines fatalistic view of dementia’ – Medical News Today (free) AND Healthy living may help offset genetic risk of dementia: study – Reuters (free) AND Healthy lifestyle may cut risk of dementia regardless of genes – The Guardian (free)


8 – Viewpoint: The Ketogenic Diet for Obesity and Diabetes—Enthusiasm Outpaces Evidence – JAMA Internal Medicine (free for a limited period)

Related Consensus Statement: Very-low-calorie Ketogenic Diet (VLCKD) in the Management of Metabolic Diseases (free)


9 – Association of Screen Time and Depression in Adolescence – JAMA Pediatrics (free for a limited period)

Commentaries: Expert reaction to a study on screen time and depression in adolescents – Science Media Centre (free) AND Increasing social media use tied to rise in teens’ depressive symptoms, study says – CNN (free)


10 – Association of Silent Myocardial Infarction and Sudden Cardiac Death – JAMA Cardiology (free for a limited period)

Commentaries: Frequency of Left Ventricular Scars at Autopsy in Persons Dying Suddenly of Coronary Artery Disease With or Without Earlier Myocardial Infarction – JAMA Cardiology (free for a limited period) AND Nearly half of sudden cardiac death victims had prior, undetected MI – Cardiovascular Business (free) AND Silent MI Often Precedes Sudden Cardiac Death, Finnish Data Confirm – TCTMD (free)


Mon July 15 – 10 Stories of The Day!

14 Jul, 2019 | 20:09h | UTC


1 – Clinical Practice: Measles – New England Journal of Medicine (free)


2 – Optimized Treatment of ST-Elevation Myocardial Infarction: The Unmet Need to Target Coronary Microvascular Obstruction as Primary Treatment Goal to Further Improve Prognosis – Circulation Research (free) (via @gonzaeperez)


3 – For the sake of doctors and patients, we must fix hospital culture – The BMJ Opinion (free)

Related: Speaking up to prevent harm: A systematic review of the safety voice literature – Safety Science (free)

When hospitals fail to create a culture where doctors and nurses can speak up patients pay the price.”


4 – 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: Moderate calorie restriction in young and middle-aged adults significantly reduces heart and metabolic risk factors independent of weight loss – NIH News Releases (free) AND Cutting calories improves health markers even in slim adults, study reports – (free) AND Cutting Just 300 Calories Per Day May Keep Your Heart Healthy – NPR (free) AND Cutting about 300 calories a day might benefit your heart, study finds – CNN (free)


5 – Viewpoint: Redefining the Physician’s Role in Cost-Conscious Care: The Potential Role of the Electronic Health Record – JAMA (free for a limited period)

“Displaying price information in EHRs could mark the next step in the transformation of the practice of medicine… The next generation of EHRs should include prices for the majority of medical products and services: medications, laboratory testing, surgical procedures, and physician visits.”


6 – Industry Payments and Physician Prescribing – JAMA Internal Medicine (free for a limited period)

Original Studies: Association of Biologic Prescribing for Inflammatory Bowel Disease With Industry Payments to Physicians – JAMA Internal Medicine (free for a limited period) AND Association Between Industry Payments to Physicians and Gabapentinoid Prescribing – JAMA Internal Medicine (free for a limited period)


7 – Urinary Tract Infections Affect Millions. The Cures Are Faltering. – The New York Times (10 articles per month are free)

“As the infections become increasingly resistant to antibiotics, some standard treatments no longer work for an ailment that was once easily cured.”


8 – Review: Diaphragmatic dysfunction – Pulmonology (free)


9 – A current appraisal of evidence for the approach to sepsis and septic shock – Therapeutic Advances in Infectious Disease (free)

Source: Critical Care Reviews Newsletter


10 – Critical Care Management of Chimeric Antigen Receptor T Cell–related Toxicity. Be Aware and Prepared – American Journal of Respiratory and Critical Care Medicine (free)

Related reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND CAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free) AND Managing the toxicities of CAR T‐cell therapy – Hematological Oncology (free)

Source: Critical Care Reviews Newsletter


Fri July 12 – 10 Stories of The Day!

12 Jul, 2019 | 08:23h | UTC


1 – Serious misdiagnosis-related harms in malpractice claims: The “Big Three” – vascular events, infections, and cancers – Diagnosis (free)

Commentaries: Diagnosis errors account for one-third of severe harm malpractice claims – Modern Healthcare (free) AND Study: 100k patients injured, die each year after misdiagnosis – UPI (free)

Related Report: Improving Diagnosis in Health Care – The National Academies of Sciences Engineering and Medicine (free)


2 – Time Course for Benefit and Risk of Clopidogrel and Aspirin after Acute Transient Ischemic Attack and Minor Ischemic Stroke: A Secondary Analysis from the POINT Randomized Trial – Circulation (link to abstract – $ for full-text)

Commentary: Clopidogrel-Aspirin in Minor Stroke/TIA of Maximum Benefit in First 21 Days – TCTMD (free)

Related Guideline: Dual Antiplatelet Therapy for Acute High-Risk TIA and Minor Ischemic Stroke – The BMJ (free)


3 – Editorial: Physician burnout: a global crisis – The Lancet (free)

Related Perspectives: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free) AND The Burnout Crisis in American Medicine – The Atlantic (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record – Harvard Business Review (free commentaries) AND Physician burnout costs up to $17B a year, task force says – HealthcareDive (free)

Related Articles: Systematic Review: Prevalence of Burnout Among Physicians (free) AND Burnout syndrome among medical residents: A systematic review and meta-analysis – PLOS One (free) AND Prevalence of Burnout in Medical and Surgical Residents: A Meta-Analysis – International Journal of Environmental Research and Public Health (free) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and commentaries) AND Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction (link to abstract and commentaries)


4 – Interventions to Treat Erectile Dysfunction and Premature Ejaculation: An Overview of Systematic Reviews – Sexual Medicine (free)

Related Guidelines: Erectile Dysfunction: AUA Guideline (free) AND An Update of the International Society of Sexual Medicine’s Guidelines for the Diagnosis and Treatment of Premature Ejaculation – Sexual Medicine (free)


5 – Preclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis? – JAMA Internal Medicine (free for a limited period)


6 – Association Between Blood Pressure Variability, Cardiovascular Disease And Mortality In Type 2 Diabetes: A Systematic Review And Meta‐Analysis – Diabetes, Obesity and Metabolism (link to abstract – $ for full-text)

Commentary: Systolic BP variability associated with increased risk of death, CV events in patients with type 2 diabetes, meta-analysis finds – ACP Diabetes (free)


7 – Health outcomes of young children born to mothers who received 2009 pandemic H1N1 influenza vaccination during pregnancy: retrospective cohort study – The BMJ (free)

Commentaries: No link between flu vaccine in pregnancy and later health problems in children – The BMJ (free) AND Swine flu jab in pregnancy safe for children as well as mothers – OnMedica (free)


8 – Perspective: New drugs: where did we go wrong and what can we do better? – The BMJ (free)

Commentary: No evidence of added benefit for most new drugs entering German healthcare system – The BMJ (free)


9 – Sugary drink consumption and risk of cancer: results from NutriNet-Santé prospective cohort – The BMJ (free)

Commentaries: Possible link between sugary drinks and cancer – The BMJ (free) Sugary drinks linked to cancer – NHS Choices (free) AND A small glass of juice or soda a day is linked to increased risk of cancer, study finds – CNN (free) AND Are sugary drinks causing cancer? – BBC (free)


10 – Quantity and quality of mental activities and the risk of incident mild cognitive impairment – Neurology (free PDF)

Commentary: Mentally stimulating activities linked to lower risk or delay of age-related memory loss – News Medical (free)


Thu July 11 – 10 Stories of The Day!

11 Jul, 2019 | 11:20h | UTC


1 – C-Reactive Protein Testing to Guide Antibiotic Prescribing for COPD Exacerbations – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: CRP Testing Can Safely Reduce Antibiotic Use for COPD Exacerbations – NEJM Journal Watch (free) AND Fingerprick Biomarker Test Can Reduce Use of Antibiotics in COPD Flares – (free)


2 – Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries – Journal of the American Heart Association (free)

Editorial: Myocardial Infarction With Nonobstructive Coronary Arteries: A Call for Individualized Treatment (free)

Related: Contemporary Diagnosis and Management of Patients With Myocardial Infarction in the Absence of Obstructive Coronary Artery Disease: A Scientific Statement From the American Heart Association (free) AND The What, When, Who, Why, How and Where of Myocardial Infarction With Non-Obstructive Coronary Arteries (MINOCA) – Circulation Journal (free) AND Systematic Review of Patients Presenting With Suspected Myocardial Infarction and Nonobstructive Coronary Arteries – Circulation (free) AND Nonobstructive Versus Obstructive Coronary Artery Disease in Acute Coronary Syndrome: A Meta‐Analysis – Journal of the American Heart Association (free)

“Patients with MINOCA and those with myocardial infarction with obstructive coronary artery disease had comparable clinical outcomes. Use of renin‐angiotensin system blockers and statins was associated with lower mortality in patients with MINOCA.”


3 – Microvascular Disease, Peripheral Artery Disease and Amputation – Circulation (free PDF)

Commentaries: Microvascular Disease Quadruples Risk of Leg Amputation – TCTMD (free) AND Microvascular Disease Anywhere in the Body May Be Linked to Higher Risk of Leg Amputations – American Heart Association (free)


4 – Drug-induced endocrinopathies and diabetes: a combo-endocrinology overview – European Journal of Endocrinology (free)


5 – Pathophysiology and management of diabetic gastroenteropathy – Therapeutics Advances in Gastroenterology (free)


6 – Quality Improvement Goals for Acute Kidney Injury – Clinical Journal of the American Society of Nephrology (free)

“Quality Improvement Goals for Acute Kidney Injury: “The AKI care process starts with the community, continues in the hospital, and ends in community, and each of these phases requires specific intervention.”” (via @CCCNPitt see Tweet)


7 – Ann Robinson’s journal review, 10 July 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.


8 – Effect of Aerobic and Resistance Exercise on Cardiac Adipose Tissues: Secondary Analyses From a Randomized Clinical Trial – JAMA Cardiology (free link for a limited period)

Commentaries: Weight Training, Aerobic Exercise Affect Cardiac Fat Mass in Different Ways – TCTMD (free) AND Aerobic, resistance exercise may reduce coronary risk for people with belly fat – UPI (free)


9 – Systolic Blood Pressure and Risk of Valvular Heart Disease: A Mendelian Randomization Study – JAMA Cardiology (free link for a limited period)

Lifetime exposure to elevated systolic BP appears to be associated with an increased risk of major valvular heart disease.”


10 – Press Release: HPV vaccine could prevent over 100,000 cancers – Public Health England (free)

Commentaries: HPV vaccine for boys ‘will prevent thousands of cancers’ – BBC (free) AND Expert reaction to HPV vaccine, modelling of cancer prevention, and introduction in September of vaccine programme for boys – Science Media Centre (free) AND UK offers HPV vaccines to boys, aims to stop 100,000 cancer cases – Reuters (free)


Wed July 10 – 10 Stories of The Day!

10 Jul, 2019 | 10:28h | UTC


1 – News Release: WHO updates global guidance on medicines and diagnostic tests to address health challenges, prioritize highly effective therapeutics, and improve affordable access – World Health Organization (free)

Guidance: World Health Organization model list of essential medicines: 21st list 2019 (free PDF) AND Executive summary: the selection and use of essential medicines 2019 (free PDF) AND World Health Organization model list of essential medicines for children: 7th list 2019 (free PDF) AND Second WHO Model List of Essential In Vitro Diagnostics (free PDF)

Commentaries: WHO List of Essential Tests Gets An Upgrade – Forbes (free) AND WHO adds new antibiotics to essential medicines list – CIDRAP (free)


2 – Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury – Acta Neurochirurgica (free)


3 – Management of Infants at Risk for Group B Streptococcal Disease – Pediatrics (free)

News Releases: AAP Updates Guidance on Preventing, Managing Infants with Group B Strep Disease – American Academy of Pediatrics (free) AND Early-onset group B strep: New guidance includes changes in dosing, assessment – AAP News (free)

Related: ACOG Guideline: Prevention of Early-Onset Group B Streptococcal Disease in Newborns (free)


4 – Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children – Nature Medicine (link to abstract – $ for full-text)

News Release: A third of children up to age 3 exposed to Zika in-utero have neurological problems – UCLA (free) AND Maternal Zika infection tied to poor development in 32% of tots – CIDRAP (free)


5 – Selective Referral Using CCTA Versus Direct Referral for Individuals Referred to Invasive Coronary Angiography for Suspected CAD: A Randomized, Controlled, Open-Label Trial – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentary: Coronary Computed Tomographic Angiography for Selective Cardiac Catheterization – CONSERVE – American College of Cardiology (free)


6 – Association Between Androgen Deprivation Therapy Use and Diagnosis of Dementia in Men with Prostate Cancer – JAMA Network Open (free)

Commentaries: Hormone therapy for prostate cancer may raise risk of Alzheimer’s, Dementia – Penn Medicine (free) AND Prostate cancer treatment linked to heightened Alzheimer’s risk – UPI (free) AND Men’s dementia risk higher after androgen deprivation therapy – OnMedica (free) AND Risk of dementia rises with prostate cancer hormone-blocking therapy – Reuters (free)


7 – Subclinical Hypothyroidism – A Review – JAMA (free link for a limited period)

Related: BMJ Guideline: Treatment of Subclinical Hypothyroidism (free guideline and commentaries)


8 – Evaluating and Managing Bradycardia – Trends in Cardiovascular Medicine (free)

Related: 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay (free guideline and resources)


9 – Management of acute variceal hemorrhage – F1000Research (free)


10 – Neuropsychiatric Sequelae in Adolescents With Acute Synthetic Cannabinoid Toxicity – Pediatrics (link to abstract – $ for full-text)

News Release: Study: Seizures, coma more common with synthetic cannabinoids than cannabis – American Academy of Pediatrics (free)

Commentary: Synthetic Cannabinoids Associated with More Comas and Seizures in Teens – NEJM Journal Watch (free)


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