Thu, August 24 – 10 Stories of The Day!

24Aug
2017

 

1 – Effect of Oral Prednisolone on Symptom Duration and Severity in Nonasthmatic Adults With Acute Lower Respiratory Tract Infection: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Oral Steroid Does Not Reduce Lower Respiratory Tract Infection Symptoms in Nonasthmatic Adults – JAMA Network (free) AND No Benefit for Oral Steroids in Lower Respiratory Tract Infection – Medscape (free registration required) AND Don’t use steroids for chest infections, GPs advised – Pulse (free)

In patients with acute respiratory infection without evidence of pneumonia or asthma, the addition of corticosteroids did not reduce symptom duration or severity.

 

2 – Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis of Individual Patient Data – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Outcomes of limited cancer screening after unprovoked VTE similar to extensive screening – ACP Hospitalist (free) AND Cancer Screening Not Recommended in Patients With VTEs – Medscape (free registration required) AND Extensive cancer screening may not improve outcomes for patients with unprovoked venous thromboembolism – 2 Minute Medicine (free) AND Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism – ASCO Post (free)

 

3 – Splenic trauma: WSES classification and guidelines for adult and pediatric patients – World Journal of Emergency Surgery (free)

 

4 – Longer sleep is associated with lower BMI and favorable metabolic profiles in UK adults: Findings from the National Diet and Nutrition Survey – PLOS One (free)

Commentaries: Short sleep linked to body mass, waist size – Reuters (free) AND Insufficient sleep may be adding to your waistline – University of Leeds, via Science Daily (free)

 

5 – ESO-ESMO 3rd international consensus guidelines for breast cancer in young women (BCY3) – The Breast (free)

 

6 – Update of EULAR recommendations for the treatment of systemic sclerosis – Annals of Rheumatic Diseases (free)

 

7 – Effect of Natriuretic Peptide–Guided Therapy on Hospitalization or Cardiovascular Mortality in High-Risk Patients With Heart Failure and Reduced Ejection Fraction: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Natriuretic Peptide-Guided Therapy No Better Than Usual Care in Heart Failure Patients – Physician’s First Watch (free) AND NT-proBNP Tx Disappoints for HF Drug Titration – MedPage Today (free registration required)

 

8 – Global Burden of Sugar-Related Dental Diseases in 168 Countries and Corresponding Health Care Costs – Journal of Dental Research (link to abstract – $ for full-text)

Commentaries: High sugar consumption gives rise to dental treatment costs in the billions – Science Daily (free)

Worldwide, people are eating far too much sugar. This has negative consequences for their teeth and for their purses: seen at the global level, the costs of dental treatment are currently running at around $172 billion”

 

9 – Benefits and Harms of Osteoporosis Medications in Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Benefits and harms of osteoporosis medications unclear for patients with CKD – Medical News Today (free) AND Benefits and harms of osteoporosis medications unclear for patients with CKD – 2 Minute Medicine (free)

Source: ACP Journal Club ($)

 

10 – National Estimates of Reductions in Acute Gastroenteritis–Related Hospitalizations and Associated Costs in US Children After Implementation of Rotavirus Vaccines – Journal of the Pediatric Infectious Diseases Society (free)

Commentary: Rotavirus vaccines continue to reduce diarrhea hospitalizations, medical costs in US kids – Medical News Today (free) AND Study: Rotavirus vaccine cuts healthcare costs in US children – CIDRAP (free)

 

Wed, August 23 – 10 Stories of The Day!

23Aug
2017

 

1 – Risk of Arterial Thromboembolism in Patients With Cancer – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Cancer Patients at Heightened Risk for Arterial Thromboembolism – American College of Cardiology, Latest in Cardiology (free) AND Thromboembolism Risk Doubled in Cancer Patients – Medscape (free registration required) AND Cancer patients carry double the short-term risk of arterial thromboembolism – Cardiovascular Business (free) AND Short-Term Risk of Arterial Thromboembolism in Newly Diagnosed Patients With Cancer – ASCO Post (free)

 

2 – Effect of Oral Dexamethasone Without Immediate Antibiotics vs Placebo on Acute Sore Throat in Adults: A Randomized Clinical Trial – JAMA (free)

Multimedia: Author Interview (free) AND JAMA Report Video (free)

Commentaries: Study Examines Effectiveness of Steroid Medication for Sore Throat – The JAMA Network (free) AND Corticosteroids for sore throat: a mixed bag of results – Clinical Advisor (free)

Source: ACP Journal Club ($)

Dexamethasone increased complete symptom resolution at 48 hours (35.4% vs 27.1%), but not at 24 hours. Trade-offs between the benefits and risks of dexamethasone in this situation are uncertain.

 

3 – Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 – Intensive Care Medicine (free)

Expert opinion of the Working Group on Prevention, AKI section, European Society of Intensive Care Medicine

 

4 – Guideline: Antenatal Corticosteroid Therapy for Fetal Maturation – American College of Obstetricians and Gynecologists (free)

See also: Summary

Related: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth – Cochrane Library (link to abstract – $ for full-text) AND A dose of corticosteroids benefit most women anticipating a preterm delivery – NIHR Signals (free)

 

5 – Guideline: Opioid Use and Opioid Use Disorder in Pregnancy – American College of Obstetricians and Gynecologists (free)

See also: Summary

Related: Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes: Executive Summary of a Joint Workshop by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, American College of Obstetricians and Gynecologists, American Academy of Pediatrics, Society for Maternal-Fetal Medicine, Centers for Disease Control and Prevention, and the March of Dimes Foundation (free)

 

6 – Is Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage among Obese and Overweight Patients as Assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative – Radiology (link to abstract – $ for full-text)

Commentaries: Weight Loss Can Slow Down Knee Joint Degeneration – RSNA Press Release (free) AND Osteoarthritis: Knee joint degeneration slowed with weight loss, study confirms – Medical News Today (free)

 

7 – Particulate Matter Exposure and Stress Hormone Levels: A Randomized, Double-Blind, Crossover Trial of Air Purification – Circulation (free)

Commentaries: Air pollution ups stress hormones, alters metabolismo – Reuters (free) AND AND Novel Study Shows How Air Pollution Increases CVD Risk – MedPage Today (free registration required) AND Air pollution linked to cardiovascular disease; air purifiers may lessen impact – American Heart Association, via Science Daily (free)

Related: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)

 

8 – Systemic Therapy for Stage IV Non–Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Commentary: ASCO Guideline on Stage IV NSCLC Therapy Updated – ASCO Post (free)

 

9 – The Saudi Thoracic Society guidelines for diagnosis and management of noncystic fibrosis bronchiectasis – Annals of Thoracic Medicine (free)

 

10 – Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets – Cancer Cell (free)

Commentaries: Liquid Biopsy Reads RNA Collected by Platelets to Diagnose Cancer – Genetic Engineering & Biotechnology News (free) AND Blood biopsy test reads platelets to detect human lung cancer – Cell Press, via EurekAlert (free)

Related: Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer – New England Journal of Medicine (link to abstract – $ for full-text) AND Video – EBV DNA Screening for Nasopharyngeal Carcinoma (free) AND Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free) AND Plasma Epstein–Barr virus DNA useful for nasopharyngeal carcinoma screening – 2 Minute Medicine (free)

 

Tue, August 22 – 10 Stories of The Day!

22Aug
2017

 

1 – Clinical Practice Guideline for Screening and Management of High Blood Pressure in Children and Adolescents – American Academy of Pediatrics (free)

News release: AAP issues new pediatric hypertension clinical practice guideline – AAP News (free)

 

2 – Factors Associated With Choice of Infant Sleep Position – Pediatrics (free)

Commentaries: Less than half of mothers place sleeping infants supine – 2 Minute Medicine (free) AND Most moms aren’t putting babies to sleep safely, study says – CNN (free) AND Less Than Half of Mothers Report Always Putting Babies to Sleep in Supine Position – Physician’s First Watch (free) AND Parents still failing to put babies to sleep on their backs – Reuters (free)

Placing infants in the supine position for sleep reduces the risk of sudden unexpected infant death and has been recommended by the American Academy of Pediatrics since 2005. Nevertheless, in this survey only 43,7% of mothers placed their infants exclusively in supine position for sleep.

 

3 – Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease – Perinatal and Paediatric Epidemiology (free)

Commentaries: Study: Hypertension in pregnancy may affect long-term heart health – UPI (free) AND Hypertension during pregnancy may affect women’s long-term cardiovascular health – Wiley, via EurekAlert (free)

Related: Women with High-Risk Pregnancies Are More Likely To Develop Heart Disease – NPR (free) AND Adverse Pregnancy Conditions, Infertility, and Future Cardiovascular Risk: Implications for Mother and Child – Cardiovascular Drugs and Therapy (free)

 

4 – Medical News & Perspectives: Chess Study Revives Debate Over Cognition-Enhancing Drugs – JAMA (free)

Related: Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)

 

5 – When surgery is just a stitch-up – The Guardian (RT @Onisillos  see Tweet)

Related article: Use of placebo controls in the evaluation of surgery: systematic review – The BMJ (free)

“With evidence mounting that many minor operations owe their success to the placebo effect, is it time to call a halt to some routine procedures?”

 

6 – Smoking Cessation Pharmacotherapy Among Smokers Hospitalized for Coronary Heart Disease – JAMA Internal Medicine (free)

Commentaries: Smokers hospitalized for heart attacks often don’t get cessation drugs – Reuters (free) AND Smokers Hospitalized for CHD Rarely Receive Cessation Pharmacotherapy During Hospitalization – American College of Cardiology, Latest in Cardiology (free)

 

7 – Re-analysis of All-Cause Mortality in the U.S. Preventive Services Task Force 2016 Evidence Report on Colorectal Cancer Screening – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Flexible Sigmoidoscopy Tied to Lower Mortality Risk – Physician’s First Watch (free) AND Flexible Sigmoidoscopy Reduces All-Cause Mortality – Medscape (free registration required)

 

8 – The American Society of Colon and Rectal Surgeons Clinical Practice Guidelines for the Management of Inherited Polyposis Syndromes – Diseases of the Colon & Rectum (free)

 

9 – Oncological patients in the intensive care unit: prognosis, decision-making, therapies and end-of-life care – Swiss Medical Weekly (free)

Source: Critical Care Review Newsletter

 

10 – Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study – Annals of Rheumatic Diseases (link to abstract – $ for full-text)

Commentaries: Elevated Uric Acid Linked to Dementia in the Elderly – MedPage Today (free registration required) AND Dementia risk may be higher in elderly patients with high serum uric acid levels – ACP Internist (free)

 

Mon, August 21 – 10 Stories of The Day!

21Aug
2017

 

1 – Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis – European Heart Journal (link to abstract – $ for full-text)

Commentaries: ‘Fat but fit’ people may still be at risk of heart disease – NHS Choices (free) AND ‘Fat but fit’ still has higher risk of heart disease, study confirms – CNN (free) AND ‘Fat but Fit’ is Myth; New UK Study Finds BMI>25 Ups MI Risk – Medscape (free registration required) AND ‘Fat but fit’ still risk heart disease – BBC (free)

 

2 – Clinical Practice Guideline: Safe Medication Use in the ICU – Critical Care Medicine (free)

See also: Executive Summary (free)

 

3 – Free Online Courses Starting Today

– Introduction to Health Technology Assessment – University of Glasgow and FutureLearn

– Science of Exercise – University of Colorado Boulder and Coursera

– Psychological First Aid – Johns Hopkins University and Coursera

– Epidemiology in Public Health Practice – Johns Hopkins University and Coursera

– Tropical Parasitology: Protozoans, Worms, Vectors and Human Diseases – Duke University, Kilimanjaro Christian Medical University College and Coursera

– Essentials of Global Health – Yale University and Coursera

– Understanding Cancer Metastasis – Johns Hopkins University and Coursera

– Advanced Neurobiology I – Peking University and Coursera

– Anatomy of the Abdomen and Pelvis; a journey from basis to clinic – Leiden University Medical Center and Coursera

– Systems Thinking In Public Health – Jonhs Hopkins University and Coursera

– Bacteria and Chronic Infections – University of Copenhagen and Coursera

– Introduction to Breast Cancer – Yale University and Coursera

– Healthcare Innovation and Entrepreneurship – Duke University and Coursera

– Foundations for Assisting in Home Care – The State University of New York and Coursera

 

4 – Acute Kidney Injury After Computed Tomography: A Meta-analysis – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary: When kidneys are injured, CT contrast isn’t the culprit – Health Imaging (free)

Related article: Risk of Acute Kidney Injury After Intravenous Contrast Media Administration – Annals of Emergency Medicine (free)

Source: Hospital Medicine Virtual Journal Club

Compared with noncontrast CT, contrast-enhanced CT was not significantly associated with either acute kidney injury, need for renal replacement therapy, or all-cause mortality.

 

5 – Trajectories of energy drink consumption and subsequent drug use during young adulthood – Drug & Alcohol Dependence (link to abstract – $ for full-text)

Commentaries: Study suggests energy drinks can lead to cocaine use – News.com.au (free text and video) AND Energy Drinks May Trigger Future Substance Use – Medscape (free registration required)

 

6 – Sleep Duration and Risk of Type 2 Diabetes – Pediatrics (link to abstract – $ for full-text)

Commentaries: Lack of sleep tied to higher risk of diabetes in kids – Reuters (free) AND Sleep in Children Linked to Later Risk of Type 2 Diabetes – AJMC (free) AND Insufficient sleep raises type 2 diabetes risk in children – Medical News Today (free) AND Sleep duration inversely related to childhood type 2 diabetes risk makers – 2 Minute Medicine (free)

 

7 – Review: Postoperative pulmonary complications – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Topic of The Week

 

8 – When Sports Injuries Lead to Arthritis in Joints – The New York Times (10 articles per month are free)

Related guideline: The Role of Athletic Trainers in Preventing and Managing Posttraumatic Osteoarthritis in Physically Active Populations: a Consensus Statement of the Athletic Trainers’ Osteoarthritis Consortium (free)

 

9 – NCCN Guidelines Insights: Palliative Care, Version 2.2017 – JNCCN (free)

Related guidelineIntegration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

10 – Neurodevelopmental outcome at 2 years for preterm children born at 22 to 34 weeks’ gestation in France in 2011: EPIPAGE-2 cohort study – The BMJ (free)

Commentaries: Ahead of their time – The BMJ (free) AND Preemies do better now than years ago, but still at risk – Reuters (free) AND Premature baby survival rates are improving – OnMedica (free)

 

Fri, August 18 – 10 Stories of The Day!

18Aug
2017

 

1 – A randomized synbiotic trial to prevent sepsis among infants in rural India – Nature (free PDF)

Commentaries: At Last, a Big, Successful Trial of Probiotics – The Atlantic (free) AND Probiotic Bacteria Could Protect Newborns From Deadly Infection – NPR Goats and Soda (free) AND Seeding the Gut Microbiome Prevents Sepsis in Infants – The Scientist (free)

 

2 – Global, regional, and national deaths, prevalence, disability-adjusted life years, and years lived with disability for chronic obstructive pulmonary disease and asthma, 1990–2015: a systematic analysis for the Global Burden of Disease Study 2015 – Lancet Respiratory Medicine (free)

Invited commentary: COPD and asthma: the emergency is clear, now is the time for action (free)

 

3 – Perspective: Saying Goodbye to Lectures in Medical School: Paradigm Shift or Passing Fad? – New England Journal of Medicine (free)

Related: Vermont Medical School Says Goodbye To Lectures – NPR (free)

 

4 – Analysis – Too much medicine: Mapping the drivers of overdiagnosis to potential solutions – The BMJ (free)

Related: Overdiagnosis, ethics, and trolley problems: why factors other than outcomes matter – The BMJ (free) AND The overdiagnosis community targets solutions – The BMJ (free) AND Are expanding disease definitions unnecessarily labelling women with polycystic ovary syndrome? – The BMJ (free) AND When technology creates uncertainty: pulse oximetry and Overdiagnosis of hypoxaemia in bronchiolitis – The BMJ (free)

 

5 – The global burden of tuberculosis mortality in children: a mathematical modelling study – The Lancet Global Health (free)

Commentaries: Tuberculosis in children: under-counted and under-treate – The Lancet Global Health (free) AND TB killed an estimated 239,000 children in 2015, nearly all of them untreated, study finds – Science Speaks Blog (free)

 

6 – A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials – BMC Nephrology (free)

Source: Critical Care Reviews Newsletter

Early initiation of RRT in critically ill patients did not result in reduced mortality, change in renal function recovery, duration of RRT, renal recovery time, mechanical ventilation time or complications.

 

7 – Recommendations for HIV Screening of Gay, Bisexual, and Other Men Who Have Sex with Men — United States, 2017 – CDC, MMWR (free)

@CDC_HIVAIDS recommends men who have sex with men be tested for HIV at least annually”. (RT @CDCMMWR see Tweet)

 

8 – Special issue: Topical Collection on Decompensated Heart Failure – Current Heart Failure Reports

Source: Critical Care Reviews Newsletter

– Inpatient Monitoring of Decompensated Heart Failure: What Is Needed? (free)

– Acute Heart Failure: Definition, Classification and Epidemiology (free)

– Mechanical Circulatory Support for Decompensated Heart Failure (free)

– Pharmacological and Non-pharmacological Treatment for Decompensated Heart Failure: What Is New? (free)

– Venous Congestion, Endothelial and Neurohormonal Activation in Acute Decompensated Heart Failure: Cause or Effect? (free)

– Current Approach to Decongestive Therapy in Acute Heart Failure (free)

 

9 – A National Implementation Project to Prevent Catheter-Associated Urinary Tract Infection in Nursing Home Residents – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Study Shows 54 Percent Drop in CAUTIs Among Nursing Home Residents – Infection Control Today (free) AND AHRQ safety program helps cut catheter infections by more than 50% among nursing home patients, JAMA study shows – Healthcare Finance (free) AND Implementing technical and socioadaptive bundles may decrease catheter-associated urinary tract infections in nursing homes – 2 Minute Medicine (free) AND Nursing homes cut urinary tract infections in half through focused effort on catheter care – Michigan University, via EurekAlert (free)

Related: Toolkit for Reducing Catheter-Associated Urinary Tract Infections (CAUTI) – Agency for Healthcare Research and Quality (free resources)

 

10 – Review: The role of bariatric surgery to treat diabetes: current challenges and perspectives – BMC Endocrine Disorders (free)

 

Thu, August 17 – 10 Stories of The Day!

17Aug
2017

 

1 – Special issue: 60 years of metformin use – Diabetologia (Source: ACP Diabetes Monthly)

– Editorial: 60 years of metformin use: a glance at the past and a look to the future (free)

– Metformin: historical overview (free)

– The mechanisms of action of metformin (free)

– Metformin: clinical use in type 2 diabetes (free)

– A new perspective on metformin therapy in type 1 diabetes (free)

– Metformin for diabetes prevention: insights gained from the Diabetes Prevention Program/Diabetes Prevention Program Outcomes Study (free)

– Metformin use in pregnancy: promises and uncertainties (free)

– Impact of metformin on cardiovascular disease: a meta-analysis of randomised trials among people with type 2 diabetes (free)

– Metformin and ageing: improving ageing outcomes beyond glycaemic control (free)

– Repurposing metformin for the prevention of cancer and cancer recurrence (free)

– The pharmacogenetics of metformin (free)

– Metformin therapy for the reproductive and metabolic consequences of polycystic ovary syndrome (free)

– The effects of metformin on gut microbiota and the immune system as research frontiers (free)

 

2 – Inactivation of porcine endogenous retrovirus in pigs using CRISPR-Cas9 – Science (link to abstract – $ for full-text)

Commentaries: Birth of CRISPR’d pigs advances hopes for turning swine into organ donos – STAT (free) AND Gene editing to remove viruses brings transplant organs from pigs a step closer – The Guardian (free) AND Gene Editing Spurs Hope for Transplanting Pig Organs Into Humans – New York Times (10 articles per month are free) AND Gene editing brings pig organ transplant closer – NHS Choices (free) AND Scientists edit pig genome with goal of human organ transplants – CNN (free text and video)

 

3 – Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Off-Pump CABG Raises Long-Term Mortality Risk – Cardiobrief (free) AND Newer method of open-heart surgery carries more risks, study finds – STAT (free)

 

4 – Benefits and safety of gabapentinoids in chronic low back pain: A systematic review and meta-analysis of randomized controlled trials – PLOS Medicine (free)

Commentaries: Gabapentinoids Seem to Offer Little Benefit, Substantial Risks in Low Back Pain – Physician’s First Watch (free) AND Evidence does not support the use of gabapentinoids for chronic low back pain – PLOS, via Science Daily (free) AND Gabapentinoids for Chronic Low Back Pain? Not So Fast – Practical Pain Management (free)

Pregabalin and gabapentin have significant risk of adverse effects without any demonstrated benefit in chronic low back pain.

 

5 – Bored reading science? Let’s change how scientists write – The Conversation (free) (RT @Onisillos see Tweet)

“Science communicators, journalists, entrepreneurs, policymakers and interested members of the general public are all motivated to follow the latest scientific research. And yet, strangely enough, science papers are a communication tool but they are not that effective at communication”.

 

6 – The Fight Against Antibiotic-Resistant Bacteria Might Start With Vaccines – Allice Callahan, via FiveThirtyEight (free) (RT @greg_folkers see Tweet with infographic)

 

7 – Cardiovascular mortality and morbidity in patients with type 2 diabetes following initiation of sodium-glucose co-transporter-2 inhibitors versus other glucose-lowering drugs (CVD-REAL Nordic): a multinational observational analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: SGLT2 Agents Cut CV Events in ‘Real-World’ Analysis – MedPage Today (free registration required) AND Cardiovascular disease and mortality appear lower in patients on SGLT2 inhibitors – ACP Diabetes (free)

Related article: Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study – Circulation (free PDF)

Another observational study suggests this class of drugs may reduce cardiovascular mortality and morbidity.

 

8 – The Risk of Adverse Pregnancy Outcomes Following Nonobstetric Surgery During Pregnancy: Estimates From a Retrospective Cohort Study of 6.5 Million Pregnancies – Annals of Surgery (free)

Source: Journal Watch ($)

we found that the risk associated with nonobstetric surgery was relatively low, confirming that surgical procedures during pregnancy are generally safe”

 

9 – Study: diet soda can really mess with your metabolism – VOX (free)

Original article: Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward – Current Biology (link to abstract – $ for full-text)

See also a related meta-analysis showing little evidence of benefit from the consumption of artificial sweeteners for weight loss in our July 18th issue (see #2)

“New research helps explain why artificial sweeteners are linked to obesity and metabolic disease”.

 

10 – Talking therapy given by parents shows promise for childhood anxiety disorders – NIHR Signal (free)

Original article: Clinical outcomes and cost-effectiveness of brief guided parent-delivered cognitive behavioural therapy and solution-focused brief therapy for treatment of childhood anxiety disorders: a randomised controlled trial – The Lancet Psychiatry (free) AND Commentary: Low-intensity interventions for anxiety disorders (free)

“70% of children receiving guided parent-delivered CBT had recovered from anxiety six months after treatment” (RT @NIHR_DC see Tweet)

 

Wed, August 16 – 10 Stories of The Day!

16Aug
2017

 

1 – The Effects of Cannabis Among Adults With Chronic Pain and an Overview of General Harms: A Systematic Review – Annals of Internal Medicine (free)

Related article: Benefits and Harms of Plant-Based Cannabis for Posttraumatic Stress Disorder: A Systematic Review – Annals of Internal Medicine (free)

Commentaries: Evidence on cannabis for chronic pain and PTSD – American College of Physician’s, via EurekAlert (free) AND Evidence Lacking on Benefits of Cannabis for Treating Chronic Pain, PTSD – Physician’s First Watch (free) AND Limited evidence available to determine effectiveness and safety of cannabis to treat chronic pain – 2 Minute Medicine (free) AND Little evidence that marijuana helps chronic pain, PTSD, studies find – CNN (free text and video)

 

2 – Blood pressure targets for hypertension in older adults – Cochrane Library (free)

Full review: Blood pressure targets for hypertension in older adults – Cochrane Library (link to abstract – $ for full-text)

Related guideline: Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older to Higher Versus Lower Blood Pressure Targets: A Clinical Practice Guideline From ACP and AAFP (free)

“At the present time there is insufficient evidence to know whether a higher BP target (less than150 to 160/95 to 105 mmHg) or a lower BP target (less than 140/90 mmHg) is better for older adults with high BP”

 

3 – Analysis of Plasma Epstein–Barr Virus DNA to Screen for Nasopharyngeal Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: EBV DNA Screening for Nasopharyngeal Carcinoma (free)

Commentaries: Can a ‘liquid biopsy’ detect cancer and save lives? – STAT (free) AND Liquid Biopsy Passes Test for Nasopharyngeal Cancer – MedPage Today (free registration required) AND Early Detection of Nasopharyngeal Cancer With EBV DNA – Medscape (free registration required) AND Plasma Epstein–Barr virus DNA useful for nasopharyngeal carcinoma screening – 2 Minute Medicine (free)

 

4 – Association of Previous Cesarean Delivery With Surgical Complications After a Hysterectomy Later in Life – JAMA Surgery (free)

Commentaries: C-Section Delivery Associated with Increased Risk of Complications from Hysterectomy – The JAMA Network (free) AND C-Section Now, Hysterectomy Complications Later? – MedPage Today (free registration required)

 

5 – Risk of head and traumatic brain injuries associated with antidepressant use among community-dwelling persons with Alzheimer’s disease: a nationwide matched cohort study – Alzheimer’s Research & Therapy (free)

Commentary: Antidepressant use increases risk of head injuries among persons with Alzheimer’s disease – University of Eastern Finland, via EurekAlert (free)

 

6 – Cholera count reaches 500 000 in Yemen – World Health Organization (free)

Commentaries: Yemen’s cholera outbreak passes 500,000 cases – CIDRAP (free) AND More Than 500,000 Infected With Cholera in Yemen – The New York Times (10 articles per month are free)

 

7 – Surgery must be a core part of health care – even in the poorest countries – The Guardian (free)

Related book: Essential Surgery – Disease Control Priorities 3 (DCP3) (free)

Related report: Global Surgery 2030 (free PDF)

Related commentary on the subject: In countries with a shortage of surgeons, other health care workers can fill in the gaps – STAT (free)

 

8 – Dexamethasone before bowel surgery reduces postoperative nausea and vomiting – NIHR Signal (free)

Original article: Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial) – The BMJ (free)

 

9 – Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality in U.S. Adults – Journal of The American College of Cardiology (link to abstract and infographic – $ for full-text)

Commentaries: Consuming Alcohol in Moderation Can Lower Mortality Risks – American College of Cardiology, Latest in Cardiology (free) AND Alcohol Consumption and All-Cause, CV, and Cancer-Related Mortality – American College of Cardiology, Latest in Cardiology (free) AND Can drinking a little bit help you live longer? – Reuters (free)

 

10 – Addressing Alcohol Use Practice Manual: An Alcohol Screening and Brief Intervention Program – American Academy of Family Physicians (free PDF)

Press release: AAFP, Baylor Partner to Create Alcohol Screening Practice Manual (free)

Commentary: Alcohol screening and brief intervention: A practice manual for clinicians – Clinical Advisor (free)

 

Tue, August 15 – 10 Stories of The Day!

15Aug
2017

 

1 – Eliminating Creatine Kinase–Myocardial Band Testing in Suspected Acute Coronary Syndrome: A Value-Based Quality Improvement – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)

Author interview: Eliminating Creatine Kinase–Myocardial Band Testing in Suspected ACS (free)

Commentaries: Eliminating CK-MB Testing in Suspected ACS – American College of Cardiology, Latest in Cardiology (free) AND Research review recommends eliminating widely ordered blood test for diagnosing heart attacks – Johns Hopkins Medicine, via Science Daily (free)

Review is first publication from national consortium of academic medical centers working to eliminate unnecessary medical tests, treatments and procedures” (from Science Daily)

 

2 – Associations Between Midlife Vascular Risk Factors and 25-Year Incident Dementia in the Atherosclerosis Risk in Communities (ARIC) Cohort – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Midlife cardiovascular risk factors may increase chances of dementia – NIH News Releases (free) AND Midlife smoking, diabetes, and hypertension associated with late life dementia – 2 Minute Medicine (free) AND Heart-healthy middle age tied to lower risk of dementia – Medical News Today (free) AND Heart disease risk in middle age tied to dementia later – Reuters (free)

 

3 – Day-to-Day Blood Pressure Variability and Risk of Dementia in a General Japanese Elderly Population: The Hisayama Study – Circulation (free)

Commentaries: Fluctuations in home-monitored blood pressure may raise dementia risk – Circulation Journal Report (free) AND Fluctuations in Blood Pressure Linked to Vascular Dementia – MedPage Today (free registration required) AND Fluctuating Home Blood Pressure Linked to Dementia – Medscape (free registration required) AND Blood pressure fluctuations linked to dementia – Reuters (free)

 

4 – Self-management interventions including action plans for patients with Chronic Obstructive Pulmonary Disease (COPD) – Cochrane Library (free)

Full review: Self-management interventions including action plans for exacerbations versus usual care in patients with chronic obstructive pulmonary disease (link to summary – $ for full-text)

Related: Asthma self-management programmes can reduce unscheduled care – NIHR Signal (free)

Self-management interventions that include a COPD exacerbation action plan are associated with improvements in health-related quality of life and lower probability of respiratory-related hospital admissions.

 

5 – Delayed breastfeeding initiation and infant survival: A systematic review and meta-analysis – PLOS One (free)

This systematic review and meta-analysis mostly of observational studies suggests early breastfeeding initiation is associated with increased survival. The authors acknowledge that there are many reasons for delayed breastfeeding initiation that may confound the relationship between breastfeeding initiation and mortality, but remember that randomized trials would not be considered ethical, so we must rely on high quality observational data. Based on their analysis, the authors suggest the implementation of programs that emphasize the importance of early initiation of breastfeeding, in addition to promoting exclusive breastfeeding.

 

6 – State of the Art Review: Advances in the diagnosis and management of neck pain – The BMJ (free)

Related guideline: Neck Pain: Revision 2017 – Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association (free)

 

7 – Neurologic Complications Associated With the Zika Virus in Brazilian Adults – JAMA Neurology (free)

Editorial: The Expanding Spectrum of Zika Virus Infections of the Nervous System (free)

Commentary: Brazilian study sheds new light on Zika neuro complications in adults – CIDRAP (free)

 

8 – Richard Lehman’s journal review, 14 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – New, Occasional, and Frequent Use of Zolpidem or Zopiclone (Alone and in Combination) and the Risk of Injurious Road Traffic Crashes in Older Adult Drivers: A Population-Based Case–Control and Case-Crossover Study – CNS Drugs (free)

Car crashes in older adult drivers: Zolpidem (aOR 2.27) > zolpidem + zopiclone combo (aOR 2.20)” (RT @psychopharmacol see Tweet)

 

10 – Risk of Stroke With Various Types of Menopausal Hormone Therapies: A National Cohort Study – Stroke (link to abstract – $ for full-text)

Source: EvidenceAlerts

This large cohort confirms an increased stroke risk with oral hormone therapies, but suggests no increased risk of stroke with transdermal or vaginal estrogen application.

 

Mon, August 14 – 10 Stories of The Day!

14Aug
2017

 

1 – Use of Alternative Medicine for Cancer and Its Impact on Survival – Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentary: Use of alternative medicine hastens death of cancer patients – Edzard Ernst (free) AND Cancer Survival Takes a Hit with Alternative Medicine – MedPage Today (free) AND Using Alternative Medicine Only for Cancer Linked to Lower Survival Rate – Yale Cancer Center, via NewsWise (free) AND ‘Alternative Medicine’ for Cancer Ups Death Risk – Medscape (free registration required)

 

2 – Free Online Courses Starting Today

– Design and Interpretation of Clinical Trials – Johns Hopkins University and Coursera

– Understanding Clinical Research: Behind the Statistics – University of Cape Town and Coursera

– Public Health in Humanitarian Crises – Johns Hopkins University and Coursera

– Health Across the Gender Spectrum – Stanford University and Coursera

– Major Depression in the Population: A Public Health Approach – Johns Hopkins University and Coursera

– An Introduction to Global Health – University of Conpenhagen and Coursera

– Health Care IT: Challenges and Opportunities – Icahn School of Medicine at Mount Sinai and Coursera

– Leading Healthcare Quality and Safety – The George Washington University and Coursera

– Easing the burden of obesity, diabetes and cardiovascular disease – The University of Sydney and Coursera

– The People, Power, and Pride of Public Health – Johns Hopkins University and Coursera

 

3 – Prevention of suicide with regulations aimed at restricting access to highly hazardous pesticides: a systematic review of the international evidence (free)

Commentaries: Regulatory control of highly hazardous pesticides to prevent self-poisoning – The Lancet Global Health (free) AND Highly hazardous pesticides: policies should focus on bans, rather than secure storage, Lancet studies suggest – Bristol Health Partners (free)

Related: Effectiveness of household lockable pesticide storage to reduce pesticide self-poisoning in rural Asia: a community-based, cluster-randomised controlled trial – The Lancet (free) AND Learning from a negative trial of lockable pesticide storage – The Lancet (free)

“A worldwide ban on the use of highly hazardous agricultural pesticides is likely to prevent tens of thousands of deaths every year”.

 

4 – Magnitude, temporal trends, and projections of the global prevalence of blindness and distance and near vision impairment: a systematic review and meta-analysis – The Lancet Global Health (free)

Invited commentary: Universal eye health: are we getting closer? (free)

Commentary: Global blindness set to ‘triple by 2050′ – BBC (free) (via Global Health NOW Newslellter)

“Blindness is set to rise at an alarming rate reaching 115 million by 2050” (RT @UniMelbMDHS see Tweet)

 

5 – Guideline: Counseling Adolescents About Contraception – American Congress of Obstetricians and Gynecologists (free)

Commentary: Contraception and adolescents: ACOG releases counseling recommendations for clinicians – Clinical Advisor (free)

 

6 – Severe infections and subsequent delayed cardiovascular disease – European Journal of Preventive Cardiology (free)

Commentary: Pneumonia Or Sepsis in Adults Associated With Increased Risk of Cardiovascular Disease – European Society of Cardiology Press Releases (free) AND Elevated Cardiovascular Risk May Linger for Several Years After a Severe Infection – TCTMD (free) AND CVD risk may rise sixfold in the year after pneumonia, sepsis – Medical News Today (free)

 

7 – Thromboembolic Risk, Bleeding Outcomes and Effect of Different Antithrombotic Strategies in Very Elderly Patients With Atrial Fibrillation: A Sub‐Analysis From the PREFER in AF (PREvention oF Thromboembolic Events–European Registry in Atrial Fibrillation) – Journal of The American Heart Association (free)

Observational study suggests anticoagulation for stroke prevention in patients with atrial fibrillation is beneficial even for very elderly subjects.

 

8 – Sildenafil for pulmonary hypertension in neonates – Cochrane Library (link to summary – $ for full-text)

“Sildenafil may help reduce mortality and improve oxygenation in neonates with pulmonary hypertension” (RT @CochraneUK see Tweet)

 

9 – Preventing Severe Asthma Exacerbations in Children. A Randomized Trial of Mite-Impermeable Bedcovers – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

Commentary: Mite-proof covers may reduce severity of asthma exacerbations in allergic children – News Medical (free)

Source: EvidenceAlerts

 

10 – Treatments for reducing menopausal hot flushes are ranked for effectiveness – NIHR Signal (free)

Original article: Vasomotor symptoms resulting from natural menopause: a systematic review and network meta-analysis of treatment effects from the National Institute for Health and Care Excellence guideline on menopause – British Journal of Obstetrics and Gynaecology (free)

 

Fri, August 11 – 10 Stories of The Day!

11Aug
2017

 

1 – The association of depression at any time to the risk of death following coronary artery disease diagnosis – European Heart Journal – Quality of Care and Clinical Outcomes (link to abstract – $ for full-text)

Commentaries: Having depression and heart disease could double death risk – Medical News Today (free) AND Death risk doubles for heart patients with depression – Cardiovascular Business (free)

Related: AAFP Guideline for the Detection and Management of Post–Myocardial Infarction Depression – Annals of Family Medicine (free)

 

2 – Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study – Arthritis Research & Therapy (free)

Commentaries: Gout Patients Run Higher Risk of Kidney Stones – MedPage Today (free registration required) AND Gout associated with elevated risk for kidney stones – MedWire News (free)

“60% increased risk of first-time nephrolithiasis versus general population, with little protection from allopurinol” (from MedPage Today)

 

3 – Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study – The Lancet HIV (free registration required)

Commentaries: PrEP on demand or every day? – The Lancet HIV (free registration required) AND HIV pre-exposure prophylaxis can be taken as needed – Reuters (free)

“four doses of PrEP around the time of sexual activity cut the risk of HIV by 97 percent” (from Reuters Health)

 

4 – Interventions for emergency contraception – Cochrane Library (link to abstract – $ for full-text)

Summary: Methods of emergency contraception (free)

 

5 – Effects of CPAP and Mandibular Advancement Devices on Health-Related Quality of Life in OSA – Chest (free)

See also a recent study showing CPAP does not reduce cardiovascular events in our July 13th issue (see #2)

“CPAP is effective in improving health-related quality of life in OSA, and Mandibular Advancement Devices may be just as effective, but further RCTs comparing the two treatments are required”.

 

6 – Strategies to prevent death by suicide: meta-analysis of randomised controlled trials – British Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Brief Intervention and Contact (BIC) to prevent suicide – Dave Cesarini, via Medium (free)

Related article: Effectiveness of brief intervention and contact for suicide attempters: a randomized controlled trial in five countries – Bulletin of the World Health Organization (free)

Source: Psychiatry Research Review

“The WHO BIC is a promising suicide prevention strategy. No other intervention showed a statistically significant effect in reducing suicide”.

 

7 – Suicide Prevention in an Emergency Department Population: The ED-SAFE Study – JAMA Psychiatry (link to abstract – Free Full Text PDF via @unpaywall)

Commentaries: Intervention Phone Calls May Save The Lives Of Suicidal Patients, Reduce New Attempts, Trial Finds – Medical Daily (free) AND National study shows interventions like telephone calls can reduce suicides – EurekAlert (free) AND Intervention Curbs New Suicide Attempts in At-Risk ED Patients – Medscape (free registration required)

Source: Psychiatry Research Review

Patients who received a multifaceted intervention that included follow-up telephone calls resulted in a 30 percent reduction in future suicide attempts” (from Medical Daily)

 

8 – The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis – The Lancet Public Health (free) (RT @equitylist see Tweet)

Invited commentary: Inequality and intergenerational transmission of complex adversity (free)

Editorial: Our greatest untapped resource (free)

 

9 – Diet and Risk of Cholecystectomy: A Prospective Study Based on the French E3N Cohort – American Journal of Gastroenterology (link to abstract – $ for full-text)

Commentary: Fewer gallbladder surgeries with Mediterranean diets – Reuters (free)

 

10 – Neuroprotective Diets Are Associated with Better Cognitive Function: The Health and Retirement Study – Journal of The American Geriatrics Society (free)

Commentaries: Cognitive decline could be reduced with a Mediterranean-style diet – Medical News Today (free) AND Mediterranean-style diets linked to better brain function in older adults – Journal of the American Geriatrics Society Research Summary (free)

 

Thu, August 10 – 10 Stories of The Day!

10Aug
2017

 

1 – Developmental follow-up of children and young people born preterm – NICE Guideline (free)

 

2 – Sleep Disorder Diagnosis During Pregnancy and Risk of Preterm Birth – Obstetrics & Gynecology (link to abstract – $ for full-text)

Commentaries: Sleep Disorders in Pregnancy Linked to Preterm Birth – Medscape (free registration required) AND Insomnia linked to premature birth in study of 3 million mothers – Nature News (free)

“Women with sleep disorders were about twice as likely to deliver babies more than six weeks early” (from Nature News)

 

3 – Effect of marijuana use on cardiovascular and cerebrovascular mortality: A study using the National Health and Nutrition Examination Survey linked mortality file – European Journal of Preventive Cardiology (free)

Commentaries: Marijuana associated with three-fold risk of death from hypertension – European Society of Cardiology, via Science Daily (free) AND Marijuana use holds three-fold blood pressure death risk: study – Reuters (free) AND Marijuana Use Tied to Death from Hypertension, Study Suggests – Physician’s First Watch (free) AND Marijuana ‘may be worse than cigarettes for cardiovascular health’ – Medical News Today (free)

 

4 – The verdict: is blogging or tweeting about research papers worth it? – The London School of Economics and Political Science (free) (RT @CLAHRC_West and @CebmOxford)

Researchers can no longer ignore social media.

 

5 – What do hypnotics cost hospitals and healthcare? – F1000 Research (free)

Source: Hospital Medicine Virtual Journal Club

“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.

 

6 – Treating subclinical thyroid dysfunction in pregnancy probably has no benefit – NIHR Signal (free) (RT see Tweet)

Related: Subclinical Hypothyroidism – NEJM Resident 360 (free) AND Levothyroxine Shows No Benefit in Older Adults with Subclinical Hypothyroidism – Physician’s First Watch (free)

“Treating subclinical thyroid dysfunction in pregnancy probably has no benefit” (RT @NIHR_DC see Tweet)

 

7 – Gadolinium deposition in the brain: summary of evidence and recommendations – The Lancet Neurology (free registration required)

Commentaries: Gadolinium deposition: practical guidelines in the face of uncertainty – The Lancet Neurology (free registration required) AND MRI Contrast Agents Accumulate in the Brain – Case Western Reserve University, via NewsWise (free)

 

8 – A systematic review to identify and assess the effectiveness of alternatives for people over the age of 65 who are at risk of potentially avoidable hospital admission – BMJ Open (free) (RT @NIHR_DC)

Alternatives to hospital admission for people aged over 65 years can be safe and reduce costs across a range of acute and chronic conditions.

 

9 – All-Cause and Specific-Cause Mortality Risk After Roux-en-Y Gastric Bypass in Patients With and Without Diabetes (link to abstract – $ for full-text)

Commentary: Gastric Bypass Sharply Lowers Death Risk for People With Diabetes, Study Finds – AJMC (free)

Case-control study suggests the procedure may reduce the risk of death in patients with diabetes.

 

10 – Tai Chi for Risk of Falls. A Meta-analysis – Journal of The American Geriatrics Society (link to abstract – $ for full-text)

Commentaries: Meta-Analysis: Tai Chi Keeps Seniors from Falling – MedPage Today (free registration required) AND Tai chi may help reduce rate of falls in older and at-risk adults – News Medical (free)

‘Can reduce fall rates by almost half during the first year’ (from MedPage Today)

 

Wed, August 9 – 10 Stories of The Day!

9Aug
2017

 

1 – New NICE Guideline: Fever in under 5s: assessment and initial management (free)

 

2 – Interventions during pregnancy and childbirth for preventing cerebral palsy: an overview of Cochrane reviews (free)

 

3 – Acute mesenteric ischemia: guidelines of the World Society of Emergency Surgery – World Journal of Emergency Surgery (free)

 

4 – Prognostic Factors for Treatment Failure in Acute Otitis Media – Pediatrics (link to abstract – $ for full-text)

Commentaries: Features predicting treatment failure in acute otitis media – 2 Minute Medicine (free) AND Study IDs Children With AOM Who Benefit From Antibiotics – Medscape (free registration required)

“Children with severe bulging of the tympanic membrane seem to benefit most from antimicrobial treatment of AOM”

 

5 – Half of papers searched for online are free to read – Nature News (free)

“Large study of open research analysed reader data from Unpaywall tool, which finds freely available versions of articles”.

 

6 – Expansion of Treatment for Hepatitis C Virus Infection by Task Shifting to Community-Based Nonspecialist Providers: A Nonrandomized Clinical Trial – Annals of Internal Medicine (free)

Commentaries: Nonspecialists Could Safely Provide Hepatitis C Care – Physician’s First Watch (free) AND HCV treatment by NPs, PCPs appears safe, effective as that provided by subspecialists – ACP Internist (free)

“Expansion of Treatment for HCV Infection by Task Shifting to Community-Based Nonspecialists” (RT @kennylinafp see Tweet)

 

7 – ANMCO Scientific Statement: clinical management of hypercholesterolaemia in patients with acute coronary syndromes – European Heart Journal (free)

 

8 – Opinion: How Low Is Too Low With Salt in Heart Failure? Randomized Studies Needed to Resolve Concern – Circulation (free)

See more on sodium intake and cardiovascular disease in our July 11th issue (see #1)

 

9 – Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Typical adults eat enough salt to damage heart – Reuters (free) AND High Dietary Sodium Linked to Subclinical Cardiac Dysfunction – Medscape (free registration required)

 

10 – How long should I take antibiotics? Exploring the Goldilocks problem – Robin Centor in KevinMD.com Blog (free)

Related: The antibiotic course has had its day – The BMJ (free) AND Keep taking the tablets: three reasons to stay the full antibiotics course – The Conversation (free) (RT @Onisillos) AND Why you really should take your full course of antibiotics – The Conversation (free)

 

Tue, August 8 – 10 Stories of The Day!

8Aug
2017

 

1 – Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome: a meta-analysis of randomised trials – The Lancet (link to abstract – $ for full-text)

Commentary: Optimal Timing of an Invasive Strategy in NSTE-ACS Patients – American College of Cardiology, Latest in Cardiology (free)

An early invasive strategy does not reduce mortality compared with a delayed invasive strategy in most patients with NSTE-ACS, but seems to reduce mortality in high-risk patients.

 

2 – Outbreak-Related Disease Burden Associated with Consumption of Unpasteurized Cow’s Milk and Cheese, United States, 2009–2014 – Emerging Infectious Diseases (free)

Commentaries: Raw milk: a superfood or super risky? – The Guardian (free) AND Raw milk and cheese cause 840 times more illnesses than pasteurized products – STAT News (free)

 

3 – State of The Art Review: Advances in the diagnosis of pneumonia in children – The BMJ (free)

 

4 – Longer sleep is associated with lower BMI and favorable metabolic profiles in UK adults: Findings from the National Diet and Nutrition Survey – PLOS One (free)

Commentary: Short sleep linked to body mass, waist size – Reuters Health (free)

 

5 – simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free) (RT @Students4BE see Tweet)

 

6 – Association of Resistance Exercise, Independent of and Combined With Aerobic Exercise, With the Incidence of Metabolic Syndrome – Mayo Clinic Proceedings (free)

Commentaries: Metabolic syndrome: An hour of resistance training per week may cut risk – Medical News Today (free) AND Resistance Training Tied to Lower Risk for Metabolic Syndrome – Physician’s First Watch (free)

 

7 – Factors Associated With Achieving a Body Mass Index of Less Than 30 After Bariatric Surgery – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Opting for Weight-Loss Surgery at Lower BMIs May Be Best for Patients’ Health, Study Suggests – University of Michigan, via NewsWise (free) AND Delayed Weight Loss Surgery Tied to Worse Outcomes – MedPage Today (free registration required) AND Weight-loss surgery may work better when patients aren’t too obese – Reuters (free) AND With bariatric surgery, a patient’s starting weight makes a difference, study finds – STAT (free)

 

8 – Richard Lehman’s journal review, 7 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Review: Environmental/lifestyle factors in the pathogenesis and prevention of type 2 diabetes – BMC Medicine (free)

 

10 – Review: Subclinical thyrotoxicosis: prevalence, causes and choice of therapy – European Journal of Endocrinology (free)

 

Mon, August 7 – 10 Stories of The Day!

7Aug
2017

 

1 – Guideline: Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition – National Institute for Health and Care Excellence (NICE – UK) (free)

 

2 – Free online courses starting today:

– Community Change in Public Health – Johns Hopkins University and Coursera

– Health for All Through Primary Health Care – Johns Hopkins University and Coursera

– Global Health at the Human-Animal-Ecosystem Interface – University of Geneva and Coursera

– Childbirth: A Global Perspective – Emory University and Coursera

– An Introduction to Population Health – University of Manchester and Coursera

– Global Adolescent Health – University of Melbourne and Coursera 

– Positive Psychiatry and Mental Health – University of Sidney and Coursera

 

3 – ANMCO Position Paper: long-term follow-up of patients with pulmonary thromboembolism – European Heart Journal (free)

 

4 – Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free)

See more on “Deprescribing” in our May 8th issue (see #4), May 9th issue (see #7) and May 15th issue (see #2), and also a related article on Current and future perspectives on the management of polypharmacy (free)

“Yes. Way Too Many Meds. Think De-prescribe”. (RT @EricTopol see Tweet)

 

5 – Design Thinking for Doctors and Nurses – New York Times (10 articles per month are free)

 

6 – Have Smartphones Destroyed a Generation? – The Atlantic (free)

Long read… very interesting.

 

7 – A comprehensive guide to the new science of treating lower back pain – VOX (free)

“Mainstream medicine has failed people with chronic back pain”

 

8 – Modifiable Risk Factors for Incident Heart Failure in Atrial Fibrillation – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentary: Risk for Incident Heart Failure in Atrial Fibrillation – American College of Cardiology, Latest in Cardiology (free)

“Lose weight, treat hypertension & diabetes, stop smoking: That’s how we might prevent heart failure” (RT @JACCJournals see Tweet)

 

9 – 2017 consensus of the Asia Pacific Heart Rhythm Society on stroke prevention in atrial fibrillation – Journal of Arrhythmia (free)

 

10 – The global crackdown on parents who refuse vaccines for their kids has begun – VOX (free)

See more on mandatory vaccination in our May 29th (see #6) and July 12th (see #5) issues

“Countries like Italy and Australia are tired of measles outbreaks — so they’re moving to fine anti-vaccine parents”.

 

Fri, August 4 – 10 Stories of The Day!

4Aug
2017

 

1 – Special issue: Public Health Research & Practice – July 2017 Edition

Editorial: Cancer screening: concerns, controversy and evidence (free)

– PSA testing for men at average risk of prostate cancer (free)

– What is overdiagnosis and why should we take it seriously in cancer screening? (free)

– History, development and future of cancer screening in Australia (free)

– Assessing the efficacy of cancer screening (free)

– Improving communication about cancer screening: moving towards informed decision making (free)

“A special issue to check out if you’re interested in cancer screening (including communication)” (RT @hildabast see Tweet)

 

2 – Discover and defeat your diagnostic errors – ACP Internist (free) (RT @acpinternist  see Tweet)

“Experts explain the causes and solutions for common mistakes in diagnosis”.

 

3 – Evidence for Health Decision Making: Beyond Randomized, Controlled Trials – New England Journal of Medicine (free)

Commentary: Why the ‘gold standard’ of medical research is no longer enough – STAT (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

 

4 – Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome – Neurology (link to abstract – $ for full-text)

Commentary: Fluoroquinolones May Up Risk of PTCS, a Rare But Serious Condition – MPR (free) (RT @AmeshAA see Tweet)

 

5 – A soft robotic exosuit improves walking in patients after stroke – Science Translational Medicine (free)

Commentaries: Robotic Exosuit Improves Walking After Stroke – Medscape (free registration required) AND Watch a robotic exoskeleton help a stroke patient walk – Science (free text and video)

 

6 – Prescribing regular drugs to prevent febrile convulsions risks more harm than benefit – NIHR Signal (free)

Original article: Prophylactic drug management for febrile seizures in children – Cochrane Library (link to summary – $ for full-text)

Benefits of anti-epileptic medication for children who’ve had a convulsion while feverish, do not outweigh harms” (RT @NIHR_DC see Tweet)

 

7 – Utilization of Statins Beyond the Initial Period After Stroke and 1‐Year Risk of Recurrent Stroke – Journal of The American College of Cardiology (free)

Commentary: Quitting statins after stroke may raise risk of another stroke – AHA / ASA Newsroom (free) AND Many Stroke Patients Stop Statins or Never Start, With Dire Consequences – TCTMD (free) AND Stopping statins after stroke may increase second-stroke risk – Reuters (free)

 

8 – Iatrogenesis in Pediatrics – AMA Journal of Ethics (free) (RT @JournalofEthics)

New issue with series of articles exploring strategies clinicians need to know to respond to adverse outcomes.

 

9 – Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines (free)

 

10 – Effect of Oral Methylprednisolone on Clinical Outcomes in Patients With IgA Nephropathy: The TESTING Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Steroid treatment for type of kidney disease associated with increased risk for serious infections – The JAMA Network (free)

Renal outcomes seemed to be less frequent in the group using methylprednisolone (5,9% vs 15,9%), but the trial was stopped early due to a significantly increased risk of serious adverse events with oral methylprednisolone vs placebo (14.7% vs 3.2%, primarily excess infections).

 

Thu, August 3 – 10 Stories of The Day!

3Aug
2017

 

1 – Correction of a pathogenic gene mutation in human embryos – Nature (free)

Nature News & Views: Biotechnology: At the heart of gene edits in human embryos (free)

Commentaries: Embryo Gene-Editing Experiment Reignites Ethical Debate – Scientific American (free) AND Scientists successfully used CRISPR to fix a mutation that causes disease. This is huge – VOX (free) AND U.S. scientists edit genome of human embryo, but cast doubt on possibility of ‘designer babies’ – STAT (free) AND Human embryos edited to stop disease – BBC (free) AND In Breakthrough, Scientists Edit a Dangerous Mutation From Genes in Human Embryos – The New York Times (10 articles per month are free)

 

2 – Choosing Wisely: An International Campaign to Combat Overuse, with new Top 10 recommendations (free) (RT @ChooseWiselyCA and @CADTH_ACMTS see Tweet with infographic)

See more on the Choosing Wisely initiative in our April 5 issue (see #6)

Choosing Wisely has prioritized 10 recommendations for limiting overuse internationally.

 

3 – Guidelines for Drinking-Water Quality: Fourth Edition Incorporating the First Addendum – World Health Organization (free)

 

4 – Neck Pain: Revision 2017 – Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association (free)

 

5 – Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trail bank – Annals of Rheumatic Diseases (link to abstract – $ for full-text) (RT @PhysioMeScience see Tweet)

“Currently, there is no good evidence to support the use of glucosamine for hip or knee OA”

 

6 – Benefits and Harms of Treatment of Asymptomatic Bacteriuria: A Systematic Review and Meta-analysis by the European Association of Urology Urological Infection Guidelines Panel (free)

“For most people, treatment was not beneficial and may be harmful. Antibiotic treatment did appear to benefit women in pregnancy and those about to undergo urological surgery”.

 

7 – Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Related guideline: NCCN Guidelines Insights: Antiemesis, Version 2.2017 (free)

Commentaries: Antipsychotic Added to ASCO Antiemetic Guide – MedPage Today (free registration required) AND New Antiemetic Guidelines Issued by ASCO – Medscape (free registration required)

 

8 – Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association (free)

 

9 – ESC Joint Working Groups on Cardiovascular Surgery and the Cellular Biology of the Heart Position Paper: Peri-operative myocardial injury and infarction in patients undergoing coronary artery bypass graft surgery (free)

Summary with 10 key points to remember: Perioperative Myocardial Injury and Infarction After CABG – American College of Cardiology, Latest in Cardiology (free)

 

10 – Canadian Urological Association-Pediatric Urologists of Canada (CUA-PUC) guideline for the diagnosis, management, and followup of cryptorchidism (free)

 

Wed, August 2 – 10 Stories of The Day!

2Aug
2017

 

1 – Breastfeeding Week Reports: Tracking Progress for Breastfeeding Policies and Programmes: Global breastfeeding scorecard 2017 – World Health Organization, UNICEF (free PDF) AND Nurturing the Health and Wealth of Nations: The Investment Case for Breastfeeding – World Health Organization, UNICEF (free PDF)

News release: Babies and mothers worldwide failed by lack of investment in breastfeeding – World Health Organization (free)

See also: UNICEF page on breastfeeding (free)

New analysis shows an investment of US$4.70 per newborn could generate US$300 billion in economic gains by 2025.

 

2 – New Series from the Lancet journals: Fungal Infections – Lancet Infectious Diseases (RT @Onisillos see Tweet)

Comment: Recovery from serious fungal infections should be realisable for everyone (free registration required)

– Fungal infections in HIV/AIDS (free registration required)

– Candida and invasive mould diseases in non-neutropenic critically ill patients and patients with haematological cancer (free registration required)

– Emerging issues, challenges, and changing epidemiology of fungal disease outbreaks (free registration required)

– Pulmonary and sinus fungal diseases in non-immunocompromised patients (free registration required)

– Improvement of fungal disease identification and management: combined health systems and public health approaches (free registration required)

– The global problem of antifungal resistance: prevalence, mechanisms, and management (free registration required)

– Immunotherapeutic approaches to treatment of fungal diseases (free registration required)

– Neglected endemic mycoses (free registration required)

“This Series of eight reports brings readers up to date on fungal infections and addresses how fungal infection management can be integrated into health systems in low-income and middle-income countries”

 

3 – New Online Calculator: The Smart Risk Score – European Society of Cardiology (RT @JGrapsa see Tweet)

“The SMART Risk Score is a tool to estimate 10-year risk for recurrent vascular events in patients with manifest cardiovascular disease”

 

4 – Guideline: Intrapartum Management of Intraamniotic Infection – American College of Obstetricians and Gynecologists (ACOG) (free)

Commentary: Guidelines on Intraamniotic Infection Released by ACOG – Medscape (free registration required)

 

5 – Predicting Risk of Serious Bacterial Infections in Febrile Children in the Emergency Department – Pediatrics (link to abstract – $ for full-text)

Commentaries: UK researchers fine-tune diagnostic tool for serious bacterial infections – CIDRAP (free) AND Clinical and biomarker-based diagnostic model identifies serious bacterial infections – 2 Minute Medicine (free)

 

6 – Report: The Metabolic Syndrome in Children and Adolescents: Shifting the Focus to Cardiometabolic Risk Factor Clustering – American Academy of Pediatrics (free)

 

7 – Only Six Nations Have Evaluated Readiness for Global Pandemic – New York Times (10 articles per month are free)

Original Report: From panic and neglect to investing in health security : financing pandemic preparedness at a national level – The World Bank (free PDF)

 

8 – Periodontal Disease and Incident Cancer Risk among Postmenopausal Women: Results from the Women’s Health Initiative Observational Cohort – Cancer Epidemiology, Biomarkers & Prevention (link to abstract – $ for full-text)

Commentary: Gum infections linked to several cancers in women – Reuters (free)

 

9 – A surprising amount of medical research isn’t made public. That’s dangerous – VOX (free)

“When the results of clinical trials aren’t made public, the consequences can be dangerous — and potentially deadly” (RT @Students4BE see Tweet)

 

10 – Internet Searches for Suicide Following the Release of “13 Reasons Why” – JAMA Internal Medicine (free)

Editorial: A Call for Social Responsibility and Suicide Risk Screening, Prevention, and Early Intervention Following the Release of the Netflix Series “13 Reasons Why” (free)

Commentaries: ‘13 Reasons Why’ might have triggered suicide searches online – STAT News (free) AND Is ’13 Reasons Why’ Helping Kids Kill Themselves? – MedPage Today (free registration required) AND Google Searches on Suicide Surge After ’13 Reasons Why’ Release: Study – Newsweek (free) Suicide-Related Internet Searches Elevated After Debut of “13 Reasons Why” – Physician’s First Watch (free)

 

Tue, August 1 – 10 Stories of The Day!

1Aug
2017

 

1 – Treatment of Latent Tuberculosis Infection: An Updated Network Meta-analysis – Annals of Internal Medicine (free)

Related: Guidelines on the management of latent tuberculosis infection – World Health Organization (free)

 

2 – Efficacy of corticosteroid treatment for severe community-acquired pneumonia: A meta-analysis – American Journal of Emergency Medicine (link to abstract – $ for full-text)

Source: More Evidence That Steroids Are Beneficial in Community-Acquired Pneumonia – Journal Watch ($)

In this meta-analysis of randomized controlled trials in patients with severe community-acquired pneumonia, corticosteroid treatment was associated with reduced in-hospital mortality and length of hospital stay.

 

3 – Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Targeted Temperature Management for 24 vs. 48 Hours After OHCA – American College of Cardiology, Latest in Cardiology (free) AND Longer Induced Cooling Not Better After Cardiac Arrest – MedPage Today (free registration required)

“Small trial shows no advantage to an additional day of cooling” (from MedPage Today)

 

4 – Diagnostic Stewardship – Leveraging the Laboratory to Improve Antimicrobial Use – JAMA (free)

“This Viewpoint discusses the potential benefits and harms of diagnostic stewardship – modifying the ordering, performance, and reporting of diagnostic tests to improve antimicrobial use”

 

5 – Report: Antibiotic Use in the United States, 2017: Progress and Opportunities – Centers for Disease Control and Prevention (free)

Commentary: CDC antibiotics report calls for all-out stewardship efforts – CIDRAP (free)

CDC report: antibiotic stewardship protects patients, saves $, slows antibiotic resistance” (RT @IDSAInfo see Tweet)

 

6 – A ‘perfect storm’ superbug: How an invasive fungus got health officials’ attention – STAT (free)

Related: CDC keeping a watchful eye on Candida auris – CIDRAP (free) AND CDC reports uptick in Candida auris cases – CIDRAP (free)

 

7 – A Dangerous, “Silent Reservoir” For Gonorrhea: The Throat – The New York Times (10 articles per month are free)

See related WHO report on the rising of “Untreatable Gonorrhea” in our July 10th issue (see #1)

“Drug-resistant gonorrhea is increasing. Now scientists say the epidemic is being driven by oral sex”. (RT @NYTHealth see Tweet)

 

8 – Richard Lehman’s journal review, 31 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

9 – Really Rapid Review: Paris IAS 2017 – HIV and ID Observations in Journal Watch Blogs (free) (RT @CarlosdelRio7 see Tweet)

Highlights from the latest International AIDS Society meeting.

 

10 – New National Guideline Clearinghouse (NGC) Summaries in Low back, Cervical and Thoracic Spine Disorders with focus on occupational health.

Low Back Disorders – American College of Occupational and Environmental Medicine (free summary from NGC – $ see original guideline in ACOEM website)

Cervical and thoracic spine disorders – American College of Occupational and Environmental Medicine (free summary from NGC – $ see original guideline in ACOEM website)

 

Mon, July 31 – 10 Stories of The Day!

31Jul
2017

 

1 – World Hepatitis Day (28 July 2017) – World Health Organization Campaign (free)

News release: Eliminate hepatitis: WHO (free)

WHO Updated Factsheets (free): Hepatitis A, Hepatitis B, Hepatitis C, Hepatitis D and Hepatitis E

 

2 – Tenofovir reduces mother-to-child hepatitis B transmission – NIHR Signal (free)

Original article: Systematic review with meta-analysis: the efficacy and safety of tenofovir to prevent mother-to-child transmission of hepatitis B virus – Alimentary Pharmacology and Therapeutics (link to abstract – $ for full-text)

 

3 – The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free)

Source: Critical Care Reviews Newsletter (free)

 

4 – “It is like texting at the dinner table”: a qualitative analysis of the impact of electronic health records on patient–physician interaction in hospitals – Journal of Innovation in Health Informatics (free)

Commentary: Doctors frustrated that electronic records steal time from patients – Reuters (free)

Related guideline: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

 

5 – Why you really should take your full course of antibiotics – The Conversation (free)

Commentary against a recent article in the BMJ arguing the antibiotic course has had its day

 

6 – FDA announces comprehensive regulatory plan to shift trajectory of tobacco-related disease, death – U.S. Food and Drug Administration (free)

Commentaries: The FDA just took a radical step to cut nicotine in cigarettes so they’re not addictive – VOX (free) AND FDA Proposes Reducing Nicotine In Cigarettes – NPR (free) AND FDA Targets Cigarettes in Broadening of Fight Against Addiction – Bloomberg (free text and video) AND FDA announces plans to slash nicotine levels in cigarettes – STAT News (free) AND FDA plans to reduce nicotine in cigarettes to non-addictive levels – The Guardian (free)

“Woooow. FDA wants to cut the nicotine in cigarettes to nonaddictive levels. This is a public health power move” (RT @onceuponA see Tweet)

 

7 – Interventions for the prevention of recurrent erysipelas and cellulitis – Cochrane Library (link to summary – $ for full-text)

Commentary: Ongoing Antibiotic Prophylaxis Helps Prevent Cellulitis Recurrence – Medscape (free registration required)

 

8 – Alcohol drinking patterns and risk of diabetes: a cohort study of 70,551 men and women from the general Danish population – Diabetologia (link to abstract – $ for full-text)

Commentaries: Drinking Alcohol 3 to 4 Days a Week Tied to Lowest Risk for Diabetes – Physician’s First Watch (free) AND Moderate drinkers less likely to develop diabetes – OnMedica (free) AND Regular alcohol consumption could cut diabetes risk, study finds  – The Guardian (free) AND Diabetes Risk May Be Lowest Drinking 3 to 4 Days Per Week – Medscape (free registration required)

Observational data suggests moderate alcohol consumption may have a possible protective effect against diabetes.

 

9 – Effectiveness of non-steroidal anti-inflammatory drugs for the treatment of pain in knee and hip osteoarthritis: a network meta-analysis – The Lancet (link to abstract – $ for full-text)

Diclofenac 150 mg/day is the most effective NSAID available at present, but are the cardiac and renal risks worth it? Paracetamol does not seem to work for this condition.

 

10 – Peer review is a black box. Let’s open it up – STAT News (free)

Related commentaries: Exposing peer review – Research Information (free) AND More than just being open: giving control to authors and credit to peer reviewers – F1000Research blog (free) AND The peer-review system for academic papers is badly in need of repair – The Conversation (free) AND Manipulating the peer review process: why it happens and how it might be prevented – LSE Impact of Social Sciences blog (free) AND ‘You never said my peer review was confidential’ — scientist challenges publisher – Nature News (free)

 

Fri, July 28 – 10 Stories of The Day!

28Jul
2017

 

1 – Application of a Lifestyle-Based Tool to Estimate Premature Cardiovascular Disease Events in Young Adults: The Coronary Artery Risk Development in Young Adults (CARDIA) Study – JAMA Internal Medicine (free) (RT @JAMAInternalMed see Tweet)

Commentaries: Healthy Heart Score performed moderately well in assessing cardiovascular disease risk in young adults – 2 Minute Medicine (free) AND Online tool predicts heart risk in young adults – Reuters Health (free)

See Health Heart Score Calculator

“An online calculator may help young people predict their risk of developing heart disease in middle age – in time to make lifestyle changes to minimize their odds of myocardial infarction or stroke” (from Reuters)

 

2 – Long working hours as a risk factor for atrial fibrillation: a multi-cohort study – European Heart Journal (free)

Commentaries: Long working week ‘may increase risk of irregular heartbeat’ – NHS Choices (free) AND Long Workdays May Be Bad for Your Heart – The New York Times (10 articles per month are free) AND Long working hours linked to heightened irregular heart rhythm risk – OnMedica (free)

 

3 – Transcatheter aortic valve implantation for aortic stenosis –NICE Guideline (free)

 

4 – Chronic kidney disease in adults – NICE Quality Standard (free)

Commentary: Give chronic kidney disease patients a statin, doctors urged – OnMedica (free)

 

5 – Low back pain and sciatica in over 16s – NICE Quality Standard (free)

Related guideline: Low back pain and sciatica in over 16s: assessment and management – NICE (free)

 

6 – Big names in statistics want to shake up much-maligned P value – Nature News (free)

“One of scientists’ favorite statistics — the P value — should face tougher standards, say leading researchers”

 

7 – Association of Changing Hospital Readmission Rates With Mortality Rates After Hospital Discharge – JAMA (link to abstract – $ for full-text)

Commentaries: Pushing Hospitals To Reduce Readmissions Hasn’t Increased Deaths – NPR (free) AND Reduction in Hospital Readmission Rate Not Associated With Increased Risk of Death Following Discharge – The JAMA Network (free) AND Lower Readmissions Not Linked to Post-Discharge Mortality Risk – MedPage Today (free registration required) AND Study: Reducing readmissions does not harm patients – Becker’s Hospital Review (free)

 

8 – Temporal trends in sperm count: a systematic review and meta-regression analysis – Human Reproduction Update (free)

Commentaries: Sperm counts among western men have halved in last 40 years: study – The Guardian (free) AND Sperm Concentrations Have Fallen 50% in Western World – Medscape (free registration required)

 

9 – Sugar intake from sweet food and beverages, common mental disorder and depression: prospective findings from the Whitehall II study – Scientific Reports (free)

Commentaries: Too much sugar could increase depression risk in men, study suggests – The Guardian (free) AND High sugar diets linked to heightened depression risk in men – The Independent (free)

Association does not imply causation, but this observational study suggests sugar intake has adverse effects on long-term psychological health.

 

10 – Retrospective analysis of newly recorded certifications of visual impairment due to diabetic retinopathy in Wales during 2007–2015 – BMJ Open (free)

Commentaries: Diabetic sight loss cut by screening, research shows – BBC (free) AND Eye screening linked to fall in sight loss in people with diabetes – NHS Choices (free)

 

Thu, July 27 – 10 Stories of The Day!

27Jul
2017

 

1 – Opinion: The antibiotic course has had its day – The BMJ (free)

Commentaries: Some Doctors Now Say to Stop Antibiotics When You Feel Better – TIME (free) AND Rule that patients must finish antibiotics course is wrong, study says – The Guardian (free)

“Experts suggest patients should stop taking the drugs when they feel better rather than completing their prescription” (from The Guardian)

 

2 – A Prospective Study on the Effect of Sport Specialization on Lower Extremity Injury Rates in High School Athletes – American Journal of Sports Medicine (link to abstract – $ for full-text)

Commentary: Student Athletes Who Specialize Early Are Injured More Often, Study Finds – NPR (free)

Related Reports: Sports Specialization and Intensive Training in Young Athletes – American Academy of Pediatrics (free) AND Overuse injuries and burnout in youth sports: a position statement from the American Medical Society for Sports Medicine (free)

 

3 – E-cigarette use and associated changes in population smoking cessation: evidence from US current population surveys – The BMJ (free)

Editorial: Rise in e-cigarette use linked to increase in smoking cessation rates (free)

Commentaries: Rise in e-cigarettes linked to rise in smokers quitting, say researchers – The BMJ, via EurekAlert (free) AND Study links rising U.S. e-cigarette use to rise in smokers quitting – Reuters (free) AND Rise in E-Cigarettes Linked to Rise in Smokers Quitting – Scoop Health (free)

Related: The shadow of Big Tobacco looms over e-cigarettes and harm reduction – STAT (free) (“Should we settle for lesser harms?”)

 

4 – Use of Prescription Smoking Cessation Medications After Myocardial Infarction Among Older Patients in Community Practice – JAMA (link to abstract – $ for full-text)

Commentaries: Stop-Smoking Meds Underused in Post-MI Setting – MedPage Today (free registration required) AND Heart attack patients don’t adhere to smoking cessation prescriptions – Cardiovascular Business (free) AND Heart attack patients missing out on smoking cessation drugs – Reuters Health (free)

 

5 – 2017 ACS Quality and Safety Conference: “Strong for Surgery” Shows Promise in Reducing Smoking Rates for Patients Facing Surgery – American College of Surgeons, via NewsWise (free)

“Study suggests big drop in smoking rates when surgeons help patients quit before their operations”.

 

6 – Tobacco Use in Top-Grossing Movies — United States, 2010–2016 – MMWR / CDC (free)

Commentaries: A new CDC report could reignite the debate over Hollywood’s influence on teen tobacco use – VOX (free) AND Health Experts Are Worried About a Huge Rise in Smoking in Movies – TIME (free) AND Tobacco gets more screen shots in blockbuster movies, study shows – New York Times (10 articles per month are free)

Source: Medscape

 

7 – Public Health and Economic Consequences of Vaccine Hesitancy for Measles in the United States – JAMA Pediatrics (free)

Commentaries: Study: Small drop in vaccine uptake can trigger measles outbreak – CIDRAP (free) AND Small decline in MMR vaccination rates could have dramatic effect, experts warn – The Guardian (free)

“A 5% drop in measles, mumps and rubella vaccinations could cause a threefold increase of measles cases, costing the public sector millions, US study shows” (from The Guardian)

 

8 – Contemporary Reviews in Critical Care Medicine: Update in Management of Severe Hypoxemic Respiratory Failure – Chest (free PDF)

 

9 – Report: Finding a Path to Safety in Food Allergy: Assessment of the Global Burden, Causes, Prevention, Management, and Public Policy – National Academies of Sciences, Engineering, and Medicine (free)

Summary: Critical Issues in Food Allergy: A National Academies Consensus Report – Pediatrics (free)

Commentary: Food Allergy: Consensus Report Stresses Diagnostic Accuracy – Medscape (free registration required)

 

10 – The Diagnosis and Treatment of Hemoptysis – Deutsches Ärzteblatt international (free)

Source: Critical Care Reviews Newsletter

 

Wed, July 26 – 10 Stories of The Day!

26Jul
2017

 

1 – Consolidated Guideline on Sexual and Reproductive Health and Rights of Women Living with HIV – World Health Organization (free)

See also: Executive Summary (free)

 

2 – Update: Interim Guidance for Health Care Providers Caring for Pregnant Women with Possible Zika Virus Exposure – MMWR / CDC (free)

Commentaries: CDC Updates Guidelines on Caring for Pregnant Women with Possible Zika Exposure – Physician’s First Watch (free) AND Updated CDC Guidance on Zika in Pregnancy – Medscape (free registration required)

 

3 – Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football – JAMA (free)

Author interview: Evaluation of Chronic Traumatic Encephalopathy in Football Players (free video)

Commentaries: High Prevalence of Evidence of CTE in Brains of Deceased Football Players – JAMA Network (free) AND Brain disease CTE seen in most football players in large report – STAT News (free) AND 110 N.F.L. Brains – The New York Times (10 articles per month are free) AND Signs of brain disease in 99 percent of ex-NFL players studied: paper – Reuters (free) AND Study: CTE Found In Nearly All Donated NFL Player Brains – NPR (free)

“A neuropathologist has examined the brains of 111 N.F.L. players — and 110 were found to have C.T.E., the degenerative disease linked to repeated blows to the head” (from NYT).

 

4 – Long-acting intramuscular cabotegravir and rilpivirine in adults with HIV-1 infection (LATTE-2): 96-week results of a randomised, open-label, phase 2b, non-inferiority trial – The Lancet (free)

Commentary: Long-Acting Injectable HIV Regimens Show Promise – Physician’s First Watch (free) AND Injections ‘next revolution’ in HIV: study – BBC (free)

 

5 – Brazilian guidelines on prevention of cardiovascular disease in patients with diabetes: a position statement from the Brazilian Diabetes Society (SBD), the Brazilian Cardiology Society (SBC) and the Brazilian Endocrinology and Metabolism Society (SBEM) – Diabetology & Metabolic Syndrome (free)

 

6 – Guidelines for the understanding and management of pain in chronic pancreatitis – Pancreatology (free)

 

7 – Cardiocerebral and cardiopulmonary resuscitation – 2017 update – Acute Medicine & Surgery (free)

Source: Critical Care Reviews Newsletter

 

8 – 2017 ISHNE-HRS expert consensus statement on ambulatory ECG and external cardiac monitoring/telemetry (free)

 

9 – Report: WHO MERS-CoV Global Summary and Assessment of Risk – World Health Organization (free PDF)

Commentary: WHO: Hospital outbreaks underscore MERS challenges – CIDRAP (free)

See also: WHO’s Work on Middle East respiratory syndrome coronavirus (MERS-CoV)

 

10 – Comparative effectiveness of high-dose versus standard-dose influenza vaccination on numbers of US nursing home residents admitted to hospital: a cluster-randomised trial – The Lancet Respiratory Medicine (free)

Commentaries: Study: High-dose flu vaccine cuts hospitalizations in nursing home residents – CIDRAP (free) AND High-dose influenza vaccine for nursing home residents reduces hospitalisations – OnMedica (free) AND High Dose Influenza Vaccine Leads to Lower Rate of Hospitalization From Respiratory Illnesses in Nursing Home Residents – University Hospitals Cleveland Medical Center, via NewsWise (free)

 

Tue, July 25 – 10 Stories of The Day!

25Jul
2017

 

1 – Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults – JAMA Internal Medicine (free)

Invited commentary: Early Orthostatic Hypotension and Orthostatic Intolerance—More Than an Observation or Annoyance (free)

Practice Changing – Orthostatic hypotension within 1 min of standing (rather than at 3 minutes) has greater relation to falls, fracture, syncope, motor vehicle crash, and mortality.

 

2 – Latest European Society of Cardiology Clinical Practice Guidelines Summary Cards are now available (Atrial Fibrillation, Heart Failure, CVD Prevention, Cardio-Oncology – free PDF summaries).

See Complete list:

– Atrial Fibrillation

– Heart Failure

– European CVD Prevention in Clinical Practice

– Cardio-oncology

– Infective Endocarditis    

– Hypertrophic Cardiomyopathy

– Cardiac Pacing & CRT

– Arterial Hypertension

– Diabetes & Pre-Diabetes, CVD

– Valvular Heart Disease  

 

3 – Public health interventions may offer society a return on investment of £14 for each £1 spent – NIHR Signal (free)

Original article: Return on investment of public health interventions: a systematic review – Journal of Epidemiology & Community Health (free)

 

4 – Viewpoint: Inconsistent Guideline Recommendations for Cardiovascular Prevention and the Debate About Zeroing in on and Zeroing LDL-C Levels With PCSK9 Inhibitors – JAMA (free)

Balanced point of view regarding the use of PCSK9 Inhibitors.

 

5 – Update on pediatric sepsis: a review – Journal of Intensive Care (free)

Source: Critical Care Reviews Newsletter

 

6 – Richard Lehman’s journal review, 24 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

7 – Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT News (free)

Related: Protecting interns and other physicians from depression and suicide – STAT News (free)

 

8 – Is cyclobenzaprine useful for pain? – Therapeutics Initiative (free)

“…cyclobenzaprine is a long-acting sedative, not a muscle relaxant, and questioning whether any potential benefits are worth the side effects”. (from TI Newsletter). “If prescribed, a dose of 5 mg at bedtime should be tried first.  Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week”.

 

9 – Canadian Cardiovascular Society and Canadian Pediatric Cardiology Association Position Statement on the Approach to Syncope in the Pediatric Patient (free)

See also: Guidelines Summary: National Guideline Clearinghouse (free)

 

10 – Damage control resuscitation in patients with severe traumatic hemorrhage: A practice management guideline from the Eastern Association for the Surgery of Trauma (free)

See also: Guideline Summary: National Guideline Clearinghouse (free)

 

Mon, July 24 – 10 Stories of The Day!

24Jul
2017

 

1 – Guidelines for the managing advanced HIV disease and rapid initiation of antiretroviral therapy – World Health Organization (free) (RT @greg_folkers see Tweet with infographic)

 

2 – WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection – World Health Organization (free) (RT @equitylist see Tweet)

Summary: WHO implementation tool for pre-exposure prophylaxis (PrEP) of HIV infection (free PDF)

See also: WHO’s Work on Pre-exposure prophylaxis (free resources)

 

3 – Review: Organ dysfunction, injury and failure in acute heart failure: from pathophysiology to diagnosis and management. A review on behalf of the Acute Heart Failure Committee of the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) (free)

 

4 – Effects of control interventions on Clostridium difficile infection in England: an observational study – The Lancet Infectious Diseases (free)

Invited Commentary: Fluoroquinolone restriction to control fluoroquinolone-resistant Clostridium difficile (free)

“Very important finding! Restricting fluoroquinolones more important than infection control measures to prevent CDI” (RT @sanjaysaint see Tweet)

 

5 – Why cancer is not a war, fight, or battle – CNN (free)

Related: He’s a Fighter – The Atlantic (free)

“Cancer is a process, it’s not a war. No winners or losers. Stop military metaphors”. (RT @lucadf see Tweet)

 

6 – “A misuse of scarce funds”: NHS to end prescription of homeopathic remedies – The Guardian (free)

Related: NHS to ban homeopathy and herbal medicine, as ‘misuse of resources’ – The Telegraph (free) AND NHS plans to scrap homeopathy treatments – BBC (free)

 

7 – Effects of Non–Vitamin K Antagonist Oral Anticoagulants Versus Warfarin in Patients With Atrial Fibrillation and Valvular Heart Disease: A Systematic Review and Meta‐Analysis – Journal of The American Heart Association (free)

“Among patients with AF and native VHD, NOACs reduce stroke and systemic embolism compared with warfarin”.

 

8 – High prevalence of erectile dysfunction in diabetes: a systematic review and meta-analysis of 145 studies – Diabetic Medicine (link to abstract – $ for full-text)

Commentary: Screening for Erectile Dysfunction Should Be Routine in Diabetes – Medscape (free registration required)

“Erectile dysfunction 3.5 times more common in diabetes” (RT @kamleshkhunti see Tweet)

 

9 – Diabetic retinopathy: current understanding, mechanisms, and treatment strategies – JCI Insight (free)

“It affects 100 M people WW, but under-diagnosed/treated: excellent review of diabetes retinopathy” (RT @EricTopol see Tweet)

 

10 – The Myth of Drug Expiration Dates – ProPublica (free)

“Hospitals and pharmacies are required to toss expired drugs, no matter how expensive or vital. Meanwhile the FDA has long known that many remain safe and potent for years longer”.

 

Fri, July 21 – 10 Stories of The Day!

21Jul
2017

 

1 – Report: HIV drug resistance report 2017 – World Health Organization (free)

News release: WHO urges action against HIV drug resistance threat (free)

Commentaries: HIV drug resistance could undermine progress in AIDS battle: WHO – Reuters (free) AND Drug-Resistant HIV Is On the Rise – TIME (free)

 

2 – Report: Ending AIDS: Progress Towards the 90-90-90 Target – Joint United Nations Programme on HIV/AIDS (UNAIDS) (free PDF)

Fact Sheet: Latest Statistics on The Status of The Aids Epidemic – UNAIDS (free) (RT @greg_folkers see Tweet)

Related editorial: The global HIV/AIDS epidemic—progress and challenges – The Lancet (free)

Commentary: For first time in history, half of all people with HIV are getting treatment – Science (free) (source: GlobalHealthNOW newsletter)

 

3 – Parkinson’s disease in adults – National Institute for Health and Care Excellence (NICE) Guideline (free)

 

4 – Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Adjusting Antiplatelet Regimen Could Decrease Risk For Stroke Patients on Aspirin Monotherapy – American College of Cardiology, Latest in Cardiology (free)

Meta-analysis of cohort studies: in patients who experienced an ischemic stroke or transient ischemic attack while on aspirin monotherapy, the addition of or a switch to another antiplatelet agent, versus aspirin monotherapy, was associated with a 32 percent reduction in the risk of major adverse cardiovascular events (HR 0.68; 0.54–0.85) and 30 percent reduction in recurrent strokes (HR, 0.70; 0.54–0.92). Additional randomized trials would better clarify the best antiplatet regimen for these patients.

 

5 – Antidepressants during pregnancy and autism in offspring: population based cohort study – The BMJ (free)

Editorial: Prenatal antidepressant use and risk of autism (free)

Commentaries: Antidepressants and pregnancy: study didn’t find they actually cause autism – The Conversation (free) AND Antidepressant use in pregnancy linked to autism in children – OnMedica (free) AND Study finds slight autism risk link to antidepressants in pregnancy – Reuters (free)

 

6 – Effect of diet and physical activity based interventions in pregnancy on gestational weight gain and pregnancy outcomes: meta-analysis of individual participant data from randomised trials – The BMJ (free)

Editorial: Diet and exercise in pregnancy (free)

Commentaries: Risk of caesarean reduced by healthy diet and physical activity during pregnancy, study finds – NewsMedical (free) AND C-Section Risk Reduction Linked to Healthy Lifestyle – MedPage Today (free)

 

7 – The Effects of Public Access Defibrillation on Survival After Out-of-Hospital Cardiac Arrest: A Systematic Review of Observational Studies – Circulation (link to abstract – $ for full-text)

Commentary: Bystander CPR Best Hope for Out-of-Hospital Cardiac Arrest? – Medscape (free registration required)

See related article on Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest in our May 4th issue (see #2)

 

8 – Report: Dementia prevention, intervention, and care – The Lancet (free registration required)

Commentaries: Experts: 1 in 3 cases of dementia preventable, nonmedical therapies ideal for dementia – University of Southern California, via EurekAlert (free) AND One Third of Dementia May Be Preventable With Lifestyle Change – Medscape (free registration required) AND Over a Third of Dementia Cases Tied to Modifiable Risk Factors – Physician’s First Watch (free) AND Living healthily, learning more could cut dementia cases by a third – Reuters (free) AND Lifestyle changes could prevent a third of dementia cases, report suggests – The Guardian (free)

 

9 – The Uncertain Future of Genetic Testing – The Atlantic (free)

“Bringing genetics into medicine leads to more accuracy, better diagnosis, and personalized treatment—but for some, gene testing has only resulted in unanswered questions”.

 

10 – An emergency department protocol to restore circulation doesn’t improve outcomes in septic shock – NIHR Signal (free)

Original article: Early, Goal-Directed Therapy for Septic Shock — A Patient-Level Meta-Analysis – New England Journal of Medicine (link to abstract – $ for full-text)

 

Thu, July 20 – 10 Stories of The Day!

20Jul
2017

 

1 – WHO report on the global tobacco epidemic 2017 – World Health Organization (free)

Full report: WHO Report on The Global Tobacco Epidemic: 2017 Monitoring tobacco use and prevention policies (free PDF)

Press release: WHO report finds dramatic increase in life-saving tobacco control policies in last decade (free)

Infographics: Protecting people from tobacco (free)

Commentaries: Taxation: Most effective but still the least-used tobacco control measure, by Patricio V. Marquez via The World Bank Blogs (free) AND Tobacco industry blocking anti-smoking moves: WHO – Reuters (free) AND Tobacco firms ‘hamper anti-smoking push’ – BBC News (free) AND Tobacco companies interfere with health regulations, WHO reports – The Guardian (free)

See also our coverage of World No Tobacco Day in our May 31 issue (see #1).

 

2 – Enhanced Prophylaxis plus Antiretroviral Therapy for Advanced HIV Infection in Africa – New England Journal of Medicine (free)

Editorial: The Enduring Challenge of Advanced HIV Infection (free)

Among HIV-infected patients with advanced immunosuppression (CD4+ count < 100 cells/mm3), enhanced antimicrobial prophylaxis combined with ART resulted in reduced rates of death.

 

3 – Efficacy and Safety of Spironolactone in Acute Heart Failure: The ATHENA-HF Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

Commentaries: High-dose spironolactone didn’t affect acute heart failure outcomes – ACP Hospitalist (free) AND High-Dose Spironolactone in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free)

 

4 – Use of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study – British Journal of Pharmacology (link to abstract – $ for full-text)

Commentary: New study finds link between certain antibiotics during pregnancy and risk for birth defects – News Medical (free)

Related article: Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free)

In this large canadian cohort clindamycin, doxycycline, quinolones, macrolides, and phenoxymethylpenicillin were associated with congenital malformations. Amoxicillin, cephalosporins, and nitrofurantoin were not associated with birth defects.

 

5 – Position statement: American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs (free PDF)

Commentaries: ASCO Offers Path to Addressing Affordability of Cancer Drugs in New Position Statement – ASCO Post (free) AND ASCO Tackles Affordability of Cancer Drugs – Physician’s First Watch (free) AND ASCO Advocates Value in Drug Pricing – MedPage Today (free registration required) AND ASCO Addresses High Cost of Cancer Drugs – Medscape (free registration required)

 

6 – Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force – Annals of Rheumatic Diseases (free)

Commentary: International Guidelines Say Use Treat-to-Target for SpA, PsA – Medscape (free registration required)

 

7 – Clinical Review: Community-associated methicillin-resistant Staphylococcus aureus infection: Literature review and clinical update – Canadian Family Physician (free)

 

8 – The Aging Physician and the Medical Profession: A Review – JAMA Sugery (free) (RT @EricTopol see Tweet)

 

9 – New Choosing Wisely Canada List: Hepatology: Five Things Physicians and Patients Should Question (free) (RT @ChooseWiselyCA see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6).

 

10 – Improving people’s health through spatial planning – Public Health England (free) (RT @pash22 see Tweet)

Related reports: Spatial planning for health: evidence review – Public Health England (free) AND Healthy people healthy places evidence tool: Evidence and practical linkage for design, planning and health – University of the West of England (free)

Related WHO Report: Preventing disease through healthy environments: a global assessment of the burden of disease from environmental risks (free) AND News release: An estimated 12.6 million deaths each year are attributable to unhealthy environments (free)

 

Wed, July 19 – 10 Stories of The Day!

19Jul
2017

 

1 – Healthful and Unhealthful Plant-Based Diets and the Risk of Coronary Heart Disease in U.S. Adults – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Some Plant-Based Diets May Increase Heart Disease Risk –American College of Cardiology, Latest in Cardiology (free) AND Not All Vegetarian, Plant-Based Diets Equal for CHD Risk – Medscape (free registration required) AND Not all plant-based diets are created equal – American College of Cardiology, via ScienceDaily (free)

 

2 – Screening Criteria for Ophthalmic Manifestations of Congenital Zika Virus Infection – JAMA Pediatrics (free)

Commentaries: Zika: Check All Potentially Exposed Infants for Eye Damage – Medscape (free registration required) AND Which Infants Exposed to Zika Virus Infection in Pregnancy Should Have Eyes Examined? – The JAMA Network (free)

“All infants with potential Zika virus exposure should have ophthalmic screening regardless of other abnormalities” (RT @PreetiNMalani see Tweet)

 

3 – The Association Between Vasectomy and Prostate Cancer: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Meta-Analysis: Vasectomy Likely Does Not Cause Prostate Cancer – Physician’s First Watch (free) AND Weak Link Between Vasectomy, Prostate Cancer – MedPage Today (free registration required)

 

4 – Draft Recommendation Statement: Ovarian Cancer: Screening – U.S. Preventive Services Task Force (free)

Commentaries: USPSTF Again Recommends Against Screening General Population for Ovarian Cancer – Physician’s First Watch (free) AND USPSTF Stays Course on Ovarian Cancer Screening: No screening for asymptomatic women – MedPage Today (free registration required)

 

5 – Review: Emerging arboviruses: Why today? – One Health (free) (RT @greg_folkers see Tweet)

 

6 – Cochrane What is the best medication for a fungal infection of the toenail? – Cochrane Library (free)

Full review: Oral antifungal medication for toenail onychomycosis – Cochrane Library (link to abstract – $ for full-text)

Terbinafine probably leads to better cure rates than azoles, with the same risk of adverse events. Griseofulvin is no better and has more adverse effects than azoles.

 

7 – Homepage – New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

New available guidelines are:

– Early and locally advanced non-small-cell lung cancer (NSCLC): ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Rectal cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Chronic myeloid leukaemia: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Newly diagnosed and relapsed mantle cell lymphoma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– Cervical cancer: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

– EANO–ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours (free)

– Management of infusion reactions to systemic anticancer therapy: ESMO Clinical Practice Guidelines (free)

– Management of toxicities from immunotherapy: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up (free)

 

8 – Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Tapering long-term opioid therapy may improve outcomes in chronic pain, review finds – ACP Internist (free) AND Opioid Reduction Therapy Offers Some Benefits to Patients with Chronic Pain – Physician’s First Watch (free) AND How tapering off opioids can help people with chronic pain – CNN (free)

“Opioid tapering:

– less pain: 8 of 8 studies

– Improved function: 5 of 5 studies

– Improved QOL: 3 of 3 studies” (RT @DavidJuurlink see Tweet)

 

9 – As Workouts Intensify, a Harmful Side Effect Grows More Common – New York Times (10 articles per month are free)

Related practical review: Exercise-Induced Emergencies in the Heat: Rhabdomyolysis & Exertional Heat Stroke – emDocs (free)

 

10 – Randomized clinical trial of comprehensive geriatric assessment and optimization in vascular surgery – British Journal of Surgery (link to abstract – $ for full-text)

Source: ACP Journal Club ($ resource to find articles of interest)

In this RCT, a comprehensive preoperative geriatric assessment and optimization before vascular surgery was associated with shorter length of hospital stay, lower incidence of complications, and patients were less likely to be discharged to a higher level of dependency.

 

Tue, July 18 – 10 Stories of The Day!

18Jul
2017

 

1 – Report: Progress and Challenges with Achieving Universal Immunization Coverage: 2016 Estimates of Immunization Coverage – WHO / UNICEF (free PDF)  (RT @WHO see Tweet )

News Release: 1 in 10 infants worldwide did not receive any vaccinations in 2016 – World Health Organization (free)

 

2 – Nonnutritive sweeteners and cardiometabolic health: a systematic review and meta-analysis of randomized controlled trials and prospective cohort studies – Canadian Medical Association Journal (free)

Commentaries: Artificial Sweeteners Not Tied to Lower BMI and May Even Increase It – Physician’s First Watch (free) AND Artificial Sweeteners Don’t Help People Lose Weight, Review Finds – NPR (free) AND The Irony Of Artificial Sweeteners – Forbes (free) AND Low-calorie sweeteners don’t help with weight loss — and may lead to gained pounds – STAT News (free)

 

3 – What proportion of health outcomes are attributable to health care – Sheffield DPH (free) (RT @gmacscotland and @felly500 see Tweet)

 

4 – The hidden truth about our prescription medications – Ideas.Ted.Com (free)

“Around half of the clinical trials that were done on the medicines we use today have never published their results…” (RT @Students4BE see Tweet)

 

5 – Why are these countries the most obese? Walking is just one reason – CNN (free) (RT @kamleshkhunti see Tweet)

Related studies: Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free) AND NIH-funded team uses smartphone data in global study of physical activity – NIH News Release (commentary, see original article$)

 

6 – Position Statement: American Association of Clinical Endocrinologists And American College Of Endocrinology Position Statement On Menopause – 2017 Update (free)

Related Position Statement: The 2017 hormone therapy position statement of The North American Menopause Society (free PDF)

Related Draft Recommendation Statement: Menopausal Hormone Therapy: Primary Prevention of Chronic Conditions – U.S. Preventive Services Task Force (free)

 

7 – Richard Lehman’s journal review, 17 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Evidence-based guidelines for fall prevention in Korea – The Korean Association of Internal Medicine and The Korean Geriatrics Society (free)

 

9 – Financing transformative health systems towards achievement of the health Sustainable Development Goals: a model for projected resource needs in 67 low-income and middle-income countries – The Lancet Global Health (free) (RT @LancetGH see Tweet)

Invited commentaries: Financing health systems to achieve the health Sustainable Development Goals (free) AND All roads lead to universal health coverage, by Tedros Adhanom Ghebreyesus, Director-General of WHO (free)

WHO News Release: WHO estimates cost of reaching global health targets by 2030 (free)

Commentaries: Global health price tag could be $371 billion a year by 2030, WHO says – Reuters (free)

 

10 – New research program and website: Access to Healthcare – Economist Intelligence Unit (all resources are free) (RT @anetrid see Tweet)

Report: Global access to healthcare: Building sustainable health systems – Economist Intelligence Unit report (free)

“This research programme, created by The Economist Intelligence Unit, examines the challenges and opportunities countries face as they attempt to improve access to high-quality healthcare that meets the needs of their populations. It consists of the Global Access to Healthcare Index, covering 60 countries with a diversity of income levels; a global report; an animated infographic introducing the key findings from the index; six infographics on the main domains of the index; and five regional summary papers”.

 

Mon, July 17 – 10 Stories of The Day!

17Jul
2017

 

1 – The management of intra-abdominal infections from a global perspective: 2017 WSES guidelines – World Journal of Emergency Surgery (free)

Related guideline: The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections (free)

 

2 – Constipation in children and young people: diagnosis and management – National Institute for Health and Care Excellence (NICE) Guideline (free)

 

3 – High-flow nasal cannula oxygen therapy is superior to conventional oxygen therapy but not to noninvasive mechanical ventilation on intubation rate: a systematic review and meta-analysis – Critical Care (free)

Source: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)

 

4 – Systematic review: Antiepileptic drug monotherapy (single drug treatment) for epilepsy – Cochrane Library (free)

Original article: Antiepileptic drug monotherapy for epilepsy: a network meta-analysis of individual participant data (link to summary – $ for full-text)

 

5 – Studies suggest apneic oxygenation reduces hypoxemia during emergency intubation:

Meta-analysis 1: Apneic oxygenation during intubation in the emergency department and during retrieval: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full-text)

Meta-analysis 2: Apneic oxygenation reduces the incidence of hypoxemia during emergency intubation: A systematic review and meta-analysis – The American Journal of Emergency Medicine (link to abstract – $ for full text)

Source: Apneic Oxygenation Prevents Desaturation During Intubation – Journal Watch ($ resource to find articles of interest)

 

6 – Risk of post-pregnancy hypertension in women with a history of hypertensive disorders of pregnancy: nationwide cohort study – The BMJ (free)

Related article: Lifestyle in progression from hypertensive disorders of pregnancy to chronic hypertension in Nurses’ Health Study II: observational cohort study – The BMJ (free)

Editorial: Hypertensive disorders of pregnancy – The BMJ (free)

Commentaries: Hypertensive Disorders of Pregnancy Tied to Increased Hypertension Risk Decades Later – Physician’s First Watch (free)

 

7 – How to spot a misleading graph, by Lea Gaslowitz – TED Talks (free YouTube video)

“How to spot a misleading graph – Great video by Lea Gaslowitz @TEDTalks” (RT @CochraneUK see Tweet)

 

8 – Opinion: Physicians need to openly discuss medical mistakes and near misses – STAT News (free) (RT @statnews see Tweet)

 

9 – “Pathologists debating their future in the era of #AI” (RT @EricTopol see Tweet)

Editorial 1: AlphaGo, Deep Learning, and the Future of the Human Microscopist – Archives of Pathology & Laboratory Medicine (free)

Editorial 2: Artificial Intelligence and the Pathologist: Future Frenemies? – Archives of Pathology & Laboratory Medicine (free)

See more on the impact of artificial intelligence in healthcare in our June 14th issue (see #2 and #3)

 

10 – A must read perspective on “Machine Learning and Prediction in Medicine — Beyond the Peak of Inflated Expectations” – Cross Invalidation (free) (RT @pash22 see Tweet)

 

Fri, July 14 – 10 Stories of The Day!

14Jul
2017

 

1 – Follow-up of Prostatectomy versus Observation for Early Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Long-term, surgery for localized prostate cancer offers little extra benefit – Reuters (free) AND No Benefit with Surgery for Low-Risk Prostate Cancer – MedPage Today (free registration required) AND Prostatectomy for Localized Prostate Cancer Doesn’t Improve Long-Term Survival – Physician’s First Watch (free) AND Surgery for Early Prostate Cancer May Not Save Lives – Washington University in St. Louis, via NewsWise (free)

“Most men just as likely to survive with limited or no treatment” (from NewsWise)

 

2 – Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and Society of American Gastrointestinal and Endoscopic Surgeons (free)

See other Enhanced Recovery After Surgery (ERAS) Guidelines and Reviews in our collection and in the ERAS Society Website.

 

3 – Clinical Guidelines for the Management of Adrenal Incidentaloma – Endocrinology and Metabolism (free)

 

4 – Association of Changes in Diet Quality with Total and Cause-Specific Mortality – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Improvement in diet quality linked to decreased all-cause mortality – 2 Minute Medicine (free) AND Improving Diet Over Time May Reduce Risk of Death – MedPage Today (free registration required) Change in Diet Can Lower Mortality Risk – Medscape (free registration required) AND Eating a Little Bit Healthier Helps You Live Longer – TIME (free) AND A Range of Healthy Dietary Changes Could Help You Live Longer – Physician’s First Watch (free)

 

5 – Insulin pumps not much better than multiple injections for intensive control of type 1 diabetes – NIHR Signal (free)

Original article: Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE) – The BMJ (free)

 

6 – Editorial: WHO downgrades status of oseltamivir – The BMJ (free)

@WHO downgrades status of oseltamivir. BMJ editorial discusses important lessons from the Tamiflu story” (RT @bmj_latest  see Tweet)

 

7 – Guidelines for the Provision and Assessment of Nutrition Support Therapy in the Pediatric Critically Ill Patient: Society of Critical Care Medicine and American Society for Parenteral and Enteral Nutrition (free)

 

8 – Enuresis: practical guidelines for primary care – British Journal of General Practice (free)

 

9 – Non-invasive ventilation for the management of acute hypercapnic respiratory failure due to exacerbation of chronic obstructive pulmonary disease – Cochrane Library (free)

NIV reduces mortality and endotracheal intubation in patients with acute hypercapnic respiratory failure secondary to an acute exacerbation COPD.

 

10 – Perspectives: Threats to Information Security: Public Health Implications – New England Journal of Medicine (free)

See related articles on Cybersecurity and Health in our June 8th issue (see #5)

 

Thu, July 13 – 10 Stories of The Day!

13Jul
2017

 

1 – Report: Progress on drinking water, sanitation and hygiene – World Health Organization (free)

News release: 2.1 billion people lack safe drinking water at home, more than twice as many lack safe sanitation (free)

“New WHO/UNICEF report: 2.1 billion ppl lack safe drinking water at home, more than 2x as many lack safe sanitation” (RT @WHO see Tweet with Infographics)

 

2 – Association of Positive Airway Pressure With Cardiovascular Events and Death in Adults With Sleep Apnea: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: More Doubt Cast on CPAP for Reducing CVD Risk in Sleep Apnea Patients – MedPage Today (free registration required) AND Positive airway pressure doesn’t reduce heart risk with sleep apnea – Reuters (free)

“PAP for obstructive sleep apnea improves quality of life but not CV events or BP with up to 5 years of follow up” (RT @AnilMakam see Tweet)

 

3 – State of The Art Review: Advances in the causes and management of community acquired pneumonia in adults – The BMJ (free)

 

4 – Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke – European Heart Journal (link to abstract – $ for full-text)

Commentary: Blood Pressure and Outcomes After Ischemic Stroke – American College of Cardiology, Latest in Cardiology (free)

Related article: Editorial: Blood Pressure in Acute Stroke Still No Answer for Management – Stroke (free PDF)

Observational analysis of over 300.000 patients suggests a J-shaped, or U-shaped relationships between BP and outcomes (both lower and higher BP levels are probably detrimental). Among patients submitted to thrombolytic therapy, there were fewer complications with lower blood pressure.

 

5 – Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Study Compares Switching Meds vs an Additional Med for Patients Unresponsive to an Antidepressant – The Jama Network (free) AND For Treatment-Resistant Depression, Add an Antipsychotic or Switch Antidepressants? – Physician’s First Watch (free)

Augmentation with aripiprazole led to a modestly increased likelihood of remission, but with more adverse effects. “Given the small effect size and adverse effects associated with aripiprazole, further analysis including cost-effectiveness is needed to understand the net utility of this approach”.

 

6 – Association Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral Prednisolone – JAMA (link to abstract – $ for full-text)

Commentaries: Alendronate Cuts Hip-Fracture Rates in High-Risk Elderly – Medscape (free registration required) AND Alendronate helps cut hip fracture risk with prednisolone – OnMedica (free) AND Alendronate Might Help Protect Against Hip Fracture in Patients Taking Prednisolone – Physician’s First Watch (free)

Retrospective cohort suggests alendronate might reduce fracture risk in the short term in elderly patients taking prednisolone.

 

7 – Large-scale physical activity data reveal worldwide activity inequality – Nature (link to abstract and free graphics – $ for full-text)

Commentaries: NIH-funded team uses smartphone data in global study of physical activity – NIH News Release (free) AND Do you live in the world’s laziest country? – BBC News (free)

 “Big data in action! Scientists analyzed smartphone data from 700k+ ppl&100 countries to study physical activity” (RT @NIHDirector see Tweet)

 

8 – Summary with 10 key points to remember: Diagnosis and Management of Resistant Hypertension – American College of Cardiology, Latest in Cardiology (free)

Original article: Diagnosis and management of resistant hypertension – Heart (link to abstract – $ for full-text)

 

9 – Meta-analysis: Safety and Efficacy of Dual Versus Triple Antithrombotic Therapy in Patients Undergoing Percutaneous Coronary Intervention – American Journal of Medicine (link to abstract – $ for full-text)

Source: EvidenceAlerts (free resource to find articles of interest)

“In patients receiving anticoagulant therapy, a strategy of single antiplatelet therapy confers a benefit of less major bleeding with no difference in all-cause mortality, cardiovascular mortality, major adverse cardiac events, myocardial infarction, stent thrombosis, or thromboembolic event rate compared with dual antiplatelet therapy”.

 

10 – Beverage Intake During Pregnancy and Childhood Adiposity – Pediatrics (free)

Commentaries: Consumption of sugar sweetened beverages during pregnancy linked to childhood obesity – 2 Minute Medicine (free) AND Drinking sugary beverages in pregnancy linked to kids’ later weight gain – Science News (free)

 

Wed, July 12 – 10 Stories of The Day!

12Jul
2017

 

1 – Association of Coffee Consumption With Total and Cause-Specific Mortality Among Nonwhite Populations – Annals of Internal Medicine (link to abstract – $ for full-text)

Related study: Coffee Drinking and Mortality in 10 European Countries: A Multinational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: No, These Two Studies Don’t Prove That Coffee Leads To Longer Life – Forbes (free) AND Coffee cuts risk of dying from stroke and heart disease, study suggests – The Guardian (free) AND Drinking coffee reduces risk of death from all causes, study finds – Imperial College of London (free)

 

2 – Behavioral Counseling to Promote a Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Cardiovascular Risk Factors: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorial 1: Healthful Physical Activity and Diet Promotion—For the Many or the Few? (free)

Editorial 2: Cardiovascular Risk Factor Control for All (free)

Editorial 3: Healthful Diet and Physical Activity for Cardiovascular Disease Prevention in Adults Without Known Risk Factors: Is Behavioral Counselling Necessary? (free)

The JAMA Network – For The Media: USPSTF Recommendation Regarding Behavioral Counseling for Cardiovascular Disease Prevention (free)

 

3 – Palliative Care in Heart Failure: The PAL-HF Randomized, Controlled Clinical Trial (link to abstract – $ for full-text)

Commentaries: Palliative Care Intervention Improves Quality of Life in Advanced Heart Failure Patients – American College of Cardiology, Latest in Cardiology (free) AND Palliative Care Improves Heart Failure Quality-of-Life – MedPage Today (free registration required)

 

4 – The weird power of the placebo effect, explained – VOX (free)

Related: Placebos can work even when patients know what they are – World Economic Forum (free)

 

5 – France is making 11 vaccines mandatory to fight against preventable disease – World Economic Forum (free)

Related: Editorial: The Guardian view on vaccinations: a matter of public health (free)

Related 2: A short history of vaccine objection, vaccine cults and conspiracy theories – The Conversation (RT @Onisillos see Tweet)(free)

See more on mandatory vaccination in other countries in our May 29 issue, see #6

 

6 – Association of delay of urgent or emergency surgery with mortality and use of health care resources: a propensity score–matched observational cohort study – Canadian Medical Association Journal (free)

Commentary: Patients whose emergency surgery is delayed are at higher risk of death – Canadian Medical Association Journal, via EurekAlert (free)

Source: STAT News Newsletter

Delayed operating room access for emergency surgery was associated with increased risk of in hospital mortality, longer length of stay and higher costs”.

 

7 – Doxycycline may be a safer first option for treating a blistering skin condition – NIHR Signal (free)

Original Article: Doxycycline versus prednisolone as an initial treatment strategy for bullous pemphigoid: a pragmatic, non-inferiority, randomised controlled trial – The Lancet (free) AND Editorial: Doxycycline: a first-line treatment for bullous pemphigoid? (free)

 

8 – Effectiveness of a group B outer membrane vesicle meningococcal vaccine against gonorrhoea in New Zealand: a retrospective case-control study – The Lancet (link to abstract – $ for full-text)

Commentaries: More reason to use Meningococcal B vaccine – it could also cut the Clap – The Conversation (author’s commentary – free) AND Meningococcal Vaccine May Provide Immunity Against Gonorrhea – Medscape (free registration required) AND Meningitis vaccine may also cut risk of ‘untreatable’ gonorrhoea, study says – The Guardian (free)

See related articles on the rising of “Untreatable” gonorrhea in our July 10th issue (see #1)

 

9 – Suturing a divided world: How providing access to surgery drives global prosperity – The Conversation (free)

Related: Essential Surgery – Disease Control Priorities (DCP3) (free landmark book on the topic) AND The Lancet Commission on Global Surgery (free resources)

Source: Global Health NOW Newsletter

 

10 – Electrocardiograms in Low-Risk Patients Undergoing An Annual Health Examination – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: More than 20% of low-risk patients receive an ECG as part of annual health exam –  Institute for Clinical Evaluative Sciences (ICES) (RT @ICESOntario and @ChooseWiselyCA see Tweet) (free) AND ECGs Common in Low-Risk Patients After Annual Health Exam, Leading to More Cardiac Care – American College of Cardiology, Latest in Cardiology (free) Routine ECG With Annual Physical Questioned – MedPage Today (free registration required)

 

Tue, July 11 – 10 Stories of The Day!

11Jul
2017

 

1 – Salt intake and Cardiovascular Disease – European Heart Journal (free)

Full report: The technical report on sodium intake and cardiovascular disease in low- and middle-income countries by the joint working group of the World Heart Federation, the European Society of Hypertension and the European Public Health Association (free)

Commentary: CardioBrief: Int’l Experts Call Sodium Guidelines Far Too Restrictive – MedPage Today (free registration required)

Summary of the technical report on sodium intake and cardiovascular disease with key recommendations for individuals and policymakers.

 

2 – Management of Small Renal Masses: American Society of Clinical Oncology Clinical Practice Guideline (free)

Summary: National Guideline Clearinghouse (free)

 

3 – Women with High-Risk Pregnancies Are More Likely To Develop Heart Disease – NPR (free)

Related review: Adverse Pregnancy Conditions, Infertility, and Future Cardiovascular Risk: Implications for Mother and Child – Cardiovascular Drugs and Therapy (free)

 

4 – Just Started! Free Online Course. Science of Exercise – University of Colorado Boulder and Coursera

 

5 – Just Started! Free Online Course. Health for All Through Primary Health Care – Johns Hopkins University and Coursera

 

6 – Effective Care for High-Need Patients: Opportunities for Improving Outcomes, Value, and Health (free PDF)

See also: News release (free) AND Executive summary (free PDF) AND Key Points (free PDF) AND Characteristics of Successful Care Models for High-Need Patients (free PDF)

Commentary: New NAM publication examines improving outcomes, reducing costs for ‘high-needs patients’ – National – National Academies of Sciences, Engineering, and Medicine, via EurekAlert (free)

See more resources on high-need, high-cost patients in our July 4th issue (see #2)

Source: STAT News Newsletter

“Nearly half of the nation’s spending on health care is driven by 5 percent of patients, and improving health outcomes and curbing spending in health care will require identifying who these high-needs patients are and providing coordinated services” (from EurekAlert)

 

7 – Richard Lehman’s journal review / 10 July 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Rivastigmine reviewed: doubts about dementia drug – Evidently Cochrane (free)

Related review: Rivastigmine for people with Alzheimer’s disease – Cochrane Library (link to abstract – $ for full-text)

“”Sadly, “small” and “of uncertain clinical importance” are the words chosen by the Cochrane reviewers to describe…” (RT @CochraneUK see Tweet)

 

9 – Cochrane Review: Gabapentin for chronic neuropathic pain in adults – Cochrane Library (link to abstract – $ for full-text)

Commentary: Analgesic Effects of Gabapentin Assessed in Chronic Neuropathic Pain – MPR (free)

“Gabapentin at doses of 1800 mg to 3600 mg daily (1200 mg to 3600 mg gabapentin enacarbil) can provide good levels of pain relief to some people with postherpetic neuralgia and peripheral diabetic neuropathy”.

 

10 – The rise of antibiotic-resistant infections threaten economies – Finantial Times (a few articles per month are free) (RT @greg_folkers see Tweet)

Related report: Drug-Resistant Infections: A Threat to Our Economic Future – World Bank (Free PDF) AND Infographic: Drug Resistant Infections: A Threat to Our Economic Future (free) AND News Release: By 2050, drug-resistant infections could cause global economic damage on par with 2008 financial crisis (free)

 

Mon, July 10 – 10 Stories of The Day!

10Jul
2017

 

1 – Scientists warn that antibiotic-resistant gonorrhoea is on the rise – World Health Organization (free)

News Release: Antibiotic-resistant gonorrhoea on the rise, new drugs needed – Word Health Organization (free)

Commentaries: Untreatable gonorrhoea on the rise worldwide – Nature News (free) AND New data show gonorrhea increasingly resistant to antibiotics  STAT News (free) AND WHO warns of imminent spread of untreatable superbug gonorrhea – Reuters (free) AND Untreatable gonorrhoea ‘superbug’ spreading around world, WHO warns – The Guardian (free)

Related guideline: WHO guidelines for the treatment of Neisseria gonorrhoeae (free)

 

2 – Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study – The Lancet (free)

Invited commentary: Determining the burden of respiratory syncytial virus disease: the known and the unknown (free)

Commentary: Experts urge action to cut child deaths from deadly lung virus – University of Edinburgh, via EurekAlert (free)

“We estimated that globally in 2015, 33.1 million episodes of RSV-ALRI, resulted in about 3.2 million hospital admissions, and 59 600 in-hospital deaths in children younger than 5 years”. (RT @greg_folkers see Tweet)

 

3 – Breaking multiple unhealthy habits all at once has modest impact, but not always… – NIHR Signal (free)

Original article: Multiple Risk Behavior Interventions: Meta-analyses of RCTs – American Journal of Preventive Medicine (free)

“Review suggests it might be sensible to tackle smoking and diet separately, rather than at the same time” (RT @NIHR_DC see Tweet)

 

4 – Diabetes in sub-Saharan Africa: from clinical care to health policy – The Lancet Diabetes & Endocrinology (free registration required)

Invited commentary: The crisis of diabetes in sub-Saharan Africa (free registration required)

Commentaries: Alarm Bells Sound on Diabetes in Sub-Saharan Africa – Medscape (free registration required) AND Increasing diabetes burden in sub-Saharan Africa has potential to reverse health gains of recent years – News Medical (free)

“The growing burden of diabetes in sub-Saharan Africa will have huge consequences” (RT @Medscape see Tweet)

 

5 – Declining Risk of Sudden Death in Heart Failure – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Has Effective Medical Therapy Made The Benefit of ICDs Uncertain? – University of Glasgow News (free) AND Net value of pacemakers/defibrillators may no longer be so clear-cut – OnMedica (free) AND Sudden Death Declining in Heart Failure – Does the trend mean that ICDs are indicated less often? – CardioBrief (free)

 

6 – The Changing Face of Clinical Trials: Master Protocols to Study Multiple Therapies, Multiple Diseases, or Both – New England Journal of Medicine (free)

See also: The Changing Face of Clinical Trials Series (free)

 

7 – Diabetes and Ramadan: Practical guidelines – Diabetes Research and Clinical Practice (free)

 

8 – Pretreatment fasting plasma glucose and insulin modify dietary weight loss success: results from 3 randomized clinical trials – American Journal of Clinical Nutrition (link to abstract – $ for full-text)

Commentaries: Fasting blood sugar, fasting insulin identified as new biomarkers for weight loss – University of Copenhagen, via ScienceDaily (free) AND Low-Fat or Low Carb for Weight Loss? It Depends on Your Glucose Metabolism – EbioMedicine (free)

Individuals with diabetes or pre-diabetes seem to have better results with low-carb diets.

 

9 – The Machines Are Getting Ready to Play Doctor – MIT Technology Review (free) (RT @EricTopol see Tweet 1 and Tweet 2)

Original article: Cardiologist-Level Arrhythmia Detection with Convolutional Neural Networks – Cornell University Library (free PDF)

In this study, a machine learning algorithm was better at diagnosing arrhythmias than cardiologists.

 

10 – Direct oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review – Blood (link to abstract – $ for full-text)

Source: Direct Oral Anticoagulants for Heparin-Induced Thrombocytopenia – Journal Watch ($)

This literature review and observational study suggest direct oral anticoagulants (rivaroxaban, apixaban, dabigatran) are safe and effective for the treatment of Heparin-Induced Thrombocytopenia.

 

Fri, July 7 – 10 Stories of The Day!

7Jul
2017

 

1 – Long-term health status and trajectories of seriously injured patients: A population-based longitudinal study – PLOS Medicine (free) (RT @karimbrohi see Tweet – “Trauma is a chronic disease”)

“The prevalence of reporting problems at 36-months postinjury was 37% for mobility, 21% for self-care, 47% for usual activities, 50% for pain/discomfort, and 41% for anxiety/depression… the prevalence of ongoing problems at 3-years postinjury is high, confirming that serious injury is frequently a chronic disorder”

 

2 – Pictograms, Units and Dosing Tools, and Parent Medication Errors: A Randomized Study – Pediatrics (link to abstract – $ for full-text)

Commentaries: Most Parents Give Kids Wrong Doses – MedPage Today (free registration required) AND Proper tools may help prevent medicine errors at home – Reuters (free)

 

3 – Free online course, starts July 17: Easing the burden of obesity, diabetes and cardiovascular disease – University of Sidney and Coursera

 

4 – SOMANZ guidelines for the investigation and management sepsis in pregnancy – Society of Obstetric Medicine Australia and New Zealand (free)

 

5 – Management of ulcerative colitis in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease – Intestinal Research (free PDF)

 

6 – Management of Crohn’s disease in Taiwan: consensus guideline of the Taiwan Society of Inflammatory Bowel Disease – Intestinal Research (free PDF)

 

7 – Suicidal Behavior During Lithium and Valproate Treatment: A Within-Individual 8-Year Prospective Study of 50,000 Patients With Bipolar Disorder – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Lithium Found to Decrease Suicide Risk in Bipolar Patients – Psychiatry News (free) AND Lithium protects against suicide – Karolinska Institutet News (free)

“Lithium, Not Valproate, Significantly Reduced Suicidal Behavior Among People With BD (an 8 y. Study)” (RT @psychopharmacol see Tweet)

 

8 – Increasing Incidence of Multiply Recurrent Clostridium difficile Infection in the United States: A Cohort Study – Annals of Internal Medicine (free)

Commentaries: Cases of recurrent Clostridium difficile infection are soaring – University of Pennsylvania School of Medicine, via EurekAlert (free) AND Multiply Recurrent C difficile Infection Rates Sharply Rise – Medscape (free registration required) AND Demand for FMT likely to increase with rise in multiply recurrent C. difficile cases – 2 Minute Medicine (free) AND Marked increase seen in multiply recurrent C diff – CIDRAP (free)

 

9 – Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Add-On Azithromycin Associated with Fewer Asthma Exacerbations – Physician’s First Watch (free)

 

10 – Cancer deaths and cases attributable to lifestyle factors and infections in China, 2013 – Annals of Oncology (link to abstract – $ for full-text)

Commentaries: Nearly half of China cancer deaths attributable to potentially modifiable risk factors – American Cancer Society, via EurekAlert (free) AND One million annual cancer deaths in China attributable to lifestyle factors – treehugger (free)

 

Thu, July 6 – 10 Stories of The Day!

6Jul
2017

 

1 – Treating Anxiety in 2017: Optimizing Care to Improve Outcomes – JAMA (free)

“Exercise, mindfulness-based stress reduction = 1st-line treatments for anxiety; move on to SSRIs and CBT as needed” (RT @JAMA_current see Tweet)

 

2 – Out of Step 2017: TB Policies in 29 countries – A Survey of Prevention, Testing and Treatment Policies and Practices – Médecins Sans Frontières (free PDF)

News release: Tuberculosis: New report highlights need to better tackle world’s deadliest infectious disease (free) (RT @MSF see Tweet)

 

3 – Consensus Review of Optimal Perioperative Care in Breast Reconstruction: Enhanced Recovery after Surgery (ERAS) Society Recommendations – Plastic & Reconstructive Surgery (free)

See also other Enhanced Recovery After Surgery (ERAS) Guidelines and Reviews in our collection and ERAS Society Website.

 

4 – Prevalence and risk factors for HIV, hepatitis B, and hepatitis C in people with severe mental illness: a total population study of Sweden – The Lancet (free)

Invited commentary: Ending HIV, hepatitis B, and hepatitis C: what about people with severe mental illness? (free)

“People with severe mental illness have 3x the general pop risk of HIV & Hepatitis B, and 9x the risk of Hepatitis C” (RT @AllenFrancesMD and @in_psych see Tweet)

 

5 – Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure in the ENGAGE AF‐TIMI 48 Trial – Journal of The American Heart Association (free)

Source: Hospital Medicine Virtual Journal Club

In this observational analysis, patients with atrial fibrillation without heart failure had increased risk of sudden cardiac death with digoxin use. Among patients with heart failure, digoxin use was associated with an increase in allcause death, cardiovascular death, sudden cardiac death, and death caused by HF/cardiogenic shock.

 

6 – Effect of Long-Term Metformin and Lifestyle in the Diabetes Prevention Program and Its Outcome Study on Coronary Artery Calcium – Circulation (free)

Commentary: Long-term Metformin May Reduce Coronary Calcium – Medscape (free registration required)

“Metformin may protect against atherosclerosis in men with pre-diabetes and early diabetes” (RT @CircAHA see Tweet)

 

7 – Physical activity, cognitive decline, and risk of dementia: 28 year follow-up of Whitehall II cohort study – The BMJ (free)

Commentary: Physical Activity Might Not Ward Off Dementia – Physician’s First Watch (free)

Contradicting previous evidence, this study did not show that physical activity has a protective effect against cognitive decline and dementia.

“Physical activity may not have an impact on your chances of being diagnosed with Alzheimer’s but it will reduce a plethora of other risks…” (RT @KarenAl46890767 see Tweet)

 

8 – Pathologists’ diagnosis of invasive melanoma and melanocytic proliferations: observer accuracy and reproducibility study – The BMJ (free)

The BMJ Opinion: Joann Elmore: When diagnostic uncertainty hits home (free)

Commentaries: Concern over huge diagnostic variability for melanoma – OnMedica (free) AND Pathologists Often Misclassify Melanoma – Physician’s First Watch (free)

 

9 – Perspective: Recognizing Sepsis as a Global Health Priority: A WHO Resolution – New England Journal of Medicine (free)

 

10 – Personal Sound Amplification Products vs a Conventional Hearing Aid for Speech Understanding in Noise – JAMA (link to abstract – $ for full-text)

The Jama Network – For the Media: Certain OTC, less expensive hearing aids provide benefit similar to conventional hearing aid (free)

Commentaries: Less Expensive Hearing Devices May Work as Well as Traditional Hearing Aids – Physician’s First Watch (free) AND Study Boosts Case for OTC Hearing Aids – MedPage Today (free registration required) AND OTC Hearing Devices Effective Alternative for Some, Study Shows – Medscape (free registration required)

“Some over-the-counter sound amplification devices are nearly as effective as prescription hearing aids, according to a small JAMA study” (from Physician’s First Watch)

 

Wed, July 5 – 10 Stories of The Day!

5Jul
2017

 

1 – Welcoming WHO’s new Director-General – Dr Tedros Adhanom Ghebreyesus (free)

See also: Vision statement by WHO Director-General (free) AND New WHO Priorities (free)

On 1 July 2017, Dr Tedros Adhanom Ghebreyesus started his 5-year term as WHO’s new Director-General.

 

2 – Risk of death among users of Proton Pump Inhibitors: a longitudinal observational cohort study of United States veterans – The BMJ Open (free)

Commentaries: Proton pump inhibitors associated with raised mortality – OnMedica (free) AND Longtime use of heartburn drugs linked to increased risk of death – NewsMedical (free) AND People taking heartburn drugs could have higher risk of death, study claims – The Guardian (free) AND Some heartburn drugs linked with higher risk of death – CBS News (free) AND PPIs Linked to Higher Risk for Death – Medscape (free registration required)

In a large observational study, PPI use was associated with increased mortality (HR 1.25; CI 1.23 to 1.28). PPIs were also associated with increased risk compared to H2 blockers (HR 1.24; CI 1.21 to 1.27). See more on the trade-offs of PPI therapy in our July 3rd issue (see #10)

 

3 – What I Wish I’d Known About My Knees – The New York Times (10 articles per month are free)

Related guideline: Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline – The BMJ (free)

“There’s little evidence to support many of the procedures people undergo in the hopes of avoiding a knee replacement”. (RT @NYTHealth see Tweet)

 

4 – 5 Tips for Understanding Data in Meta-Analyses – Absolutely Maybe Blog, by Hilda Bastian (free) (RT @hildabast see Tweet)

 

5 – New Choosing Wisely Canada List: Medical Education: Residents: Five Things Residents and Patients Should Question (free) (RT @ChooseWiselyCA see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue (see #6).

 

6 – Viewpoints in Precision Medicine:

Views and Reviews: Margaret McCartney: Are we too captivated by precision medicine? – The BMJ (free)

Related: Chief medical officer calls for gene testing revolution – BBC (free) AND Make DNA tests routine, says UK’s chief medical officer – The Guardian (free)

“Sally Davies calls for making genomic testing as common as blood tests to usher in the era of precision medicine to treat cancers and rare diseases” (from The Guardian).

 “Precision medicine is also, paradoxically, a recipe for unhelpful early diagnosis, false alarms, poor sensitivity, and conflicts of interest” (from The BMJ). 

 

7 – Allergy Testing in Children With Low-Risk Penicillin Allergy Symptoms – Pediatrics (link to abstract – $ for full-text)

Commentaries: Penicillin Allergy in Children Substantially Overreported – Medscape (free registration required) AND No Penicillin Allergy Found in Most Kids with Non-Specific Symptoms – MedPage Today (free registration required) AND Low risk allergy symptoms not linked to true penicillin allergy – 2 minute medicine (free)

Related article: Penicillin Allergy Is Not Necessarily Forever – JAMA (free)

 

8 – Herpes Zoster Increases the Risk of Stroke and Myocardial Infarction – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Does Shingles Increase the Risk of Heart Attack, Stroke? – American College of Cardiology, Latest in Cardiology (free) AND Shingles may up risk of heart attack, stroke – Reuters Health (free) AND Heart attack and stroke risk higher with shingles – OnMedica (free)

 

9 – Editorial: Sharing Medicine – A JAMA Internal Medicine Series (free)

1st article: Sharing as the Future of Medicine – JAMA Internal Medicine (free)

 

10 – Essays on health: microbes aren’t the enemy, they’re a big part of who we are – The Conversation (free) (RT @Onisillos see Tweet)

 

Tue, July 4 – 10 Stories of The Day!

4Jul
2017

 

1 – Indications for Surgical Management of Hyperparathyroidism: A Review – JAMA Surgery (free)

 

2 – Redesigning Care for High-Cost, High-Risk Patients – Harvard Business Review (a few articles per month are free) (RT @pash22 see Tweet)

Related: Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers – The Commonwealth Fund (free) AND Caring for High-Need, High-Cost Patients — An Urgent Priority – New England Journal of Medicine (free) AND Multimorbidity: clinical assessment and management – NICE Guideline (free) AND Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology (free) AND Focusing on High-Cost Patients — The Key to Addressing High Costs? – NEJM Catalyst (free) AND Richard Smith: The challenge of high need, high cost patients – The BMJ Blogs (free) AND Playbook: Better Care for People with Complex Needs – Institute for Healthcare Improvement (free)

 

3 – South African guideline for the management of community-acquired pneumonia in adults – Journal of Thoracic Diseases (free)

Source: Critical Care Reviews Newsletter

 

4 – Prognostic Value of Noninvasive Cardiovascular Testing in Patients With Stable Chest Pain – Circulation (link to abstract – $ for full-text)

Commentary: CT angiography appears better at predicting future risk for patients with chest pain – Massachusetts General Hospital, via ScienceDaily (free)

Source: EvidenceAlerts (free resource to find articles of interest)

“The most important result indicated that the ability of coronary CTA to identify nonobstructive coronary artery disease – a less-than-70-percent narrowing of a coronary artery – identifies an at-risk group of patients not found by functional testing” (from ScienceDaily).

 

5 – Social Determinants of Health Visualization – Institute for Health Metrics and Evaluation (IHME) (free interactive tool)

“The Social Determinants of Health visualization tool allows you to explore the relationships between determinants of health and health indicators across countries … users can visualize the relationships between these determinants and life expectancy, disability-adjusted life years (DALYs) by cause, years lived with disability (YLDs) by cause, and causes of death”.

 

6 – The 8 Things That End Childhood Too Soon: What Clinicians Should Know – Medscape (free registration required)

See also: Stolen Childhoods: End of Childhood Report 2017 (free PDF) AND Save the Children Website (free)

 “In this report, Save the Children examined the life events that often signal the end of childhood for too many of the world’s most vulnerable and disadvantaged kids: girls, refugees, street children, and children with disabilities” (from Medscape).

 

7 – Obesity Pathogenesis: An Endocrine Society Scientific Statement – Endocrine Reviews (free PDF)

Commentaries: Endocrine Society issues Scientific Statement on obesity’s causes – The Endocrine Society, via EurekAlert (free) AND After Weight Loss, How To Keep The Weight Off Is The Challenge – Reuters Health (free)

 

8 – Association of Electroconvulsive Therapy With Psychiatric Readmissions in US Hospitals – JAMA Psychiatry (free)

Editorial: Modern Electroconvulsive Therapy: Vastly Improved Yet Greatly Underused – JAMA Psychiatry (free) (RT @JAMA_current see Tweet)

In this observational study, electroconvulsive therapy was associated with reduced 30-day readmission risk among psychiatric inpatients with severe affective disorders.

 

9 – Richard Lehman’s journal review, 3 July 2017 – The BMJ Blogs (free)

Richard Lehman’s weekly review of medical journals.

 

10 – Functional Dyspepsia: Advances in Diagnosis and Therapy – Gut and Liver (free)

Commentary: Diagnosis and Treatment of Functional Dyspepsia – PracticeUpdate (free registration required)

Related guideline: ACG and CAG Clinical Guideline: Management of Dyspepsia – American College of Gastroenterology and Canadian Association of Gastroenterology (free PDF)

 

Mon, July 3 – 10 Stories of The Day!

3Jul
2017

 

1 – Diagnosis and management of myocardial involvement in systemic immune-mediated diseases: a position statement of the European Society of Cardiology Working Group on Myocardial and Pericardial Disease – European Heart Journal (free) (RT @rafavidalperez see Tweet)

 

2 – Air pollution: outdoor air quality and health – NICE Guideline (free)

News release: ‘No idling’ zones can help to protect vulnerable people from air pollution, says NICE (free)

See related articles on Air Pollution and Health in our June 30th issue (see #4)

 

3 – Subclinical Hypothyroidism – NEJM Resident 360 (free)

Short and practical review with algorithm on the management of subclinical hypothyroidism.

 

4 – Medical News & Perspectives: Can a Diet That Mimics Fasting Turn Back the Clock? – JAMA (free)

“A Longer Life Through Fasting?” (RT @JAMA_current see Tweet)

 

5 – When Anxiety or Depression Masks a Medical Problem – New York Times (10 articles month are free)

Related: Managing Anxiety in the Medically Ill – Psychiatric Times (free)

“Very 1st differential before making a psych diagnosis should be – is this due to medical problem? 2nd question – medication/substance/alcohol? (RT @AllenFrancesMD see Tweet)

 

6 – Living Systematic Reviews are going live – Cochrane UK (free) (RT @CochraneUK see Tweet)

Related: Living Systematic Reviews – Cochrane Community (free)

“Living Systematic Review is a “systematic review which is continually updated, incorporating relevant new evidence as it becomes available”.

 

7 – Practice: I am your trans patient – The BMJ (free)

Related infographic: Managing disclosure of gender dysphoria – The BMJ (free PDF)

“Five transgender authors share their experiences of healthcare & the important messages they’d like doctors to know” (RT @bmj_latest see Tweet)

 

8 – Editorial: Judging the benefits and harms of medicines – The BMJ (free for 15 days)

“Please read/comment on our editorial @bmj_latest about @acmedsci report on judging benefits and harms of medicines” (RT @fgodlee see Tweet)

 

9 – Translating Delirium Prevention Strategies for Elderly Adults with Hip Fracture into Routine Clinical Care: A Pragmatic Clinical Trial – Journal of the American Geriatrics Society (free)

Source: PracticalReviews ($)

See related article on the effect of multicomponent nonpharmacologic interventions to prevent delirium in abdominal surgery in our May 25th issue (see #5)

Delirium-friendly preprinted postoperative orders executed by regular nursing staff resulted in a significant reduction in postoperative delirium.

 

10 – Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free)

Commentary: Complications of Proton Pump Inhibitor Therapy – PracticeUpdate (free registration required)

Related: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD – Journal of the American Society of Nephrology (free) AND Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis – Jama Neurology (free)

The authors of this review argue that the observational studies that brought up the safety issues associated with PPIs (above studies, for example) are insufficient to establish causation and suggest a more balanced approach to PPI prescribing.

 

Fri, June 30 – 10 Stories of The Day!

30Jun
2017

 

1 – Interventions for preventing high altitude illness: Part 1. Commonly-used classes of drugs – Cochrane Library (link to summary – $ for full-text) (RT @CochraneUK see Tweet)

Acetazolamide seems to be effective to prevent acute high-altitude illness in dosages of 250 to 750 mg/day.

 

2 – Comparison of Outcome of Coronary Artery Bypass Grafting Versus Drug-Eluting Stent Implantation for Non–ST-Elevation Acute Coronary Syndrome – The American Journal of Cardiology (link to abstract – $ for full-text)

Source: EvidenceAlerts

In patients with Non–ST-Elevation Acute Coronary Syndrome and left main or multivessel CAD, CABG significantly reduced the risk of death from any causes, myocardial infarction, or stroke compared with PCI with drug-eluting stents.

 

3 – A Placebo-Controlled Trial of Antibiotics for Smaller Skin Abscesses – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Adding Antibiotics to Incision-and-Drainage of Small Skin Abscesses Helps – Physician’s First Watch (free) AND Antibiotics Improve Short-Term Outcomes for Simple Abscesses – Medscape (free registration required) AND Study finds benefit for antibiotic treatment of simple skin wounds – CIDRAP (free)

 

4 – Air Pollution and Mortality in the Medicare Population – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Air Pollution and Mortality (free)

Editorial: Air Pollution Still Kills (link to abstract – $ for full-text)

Commentary: Study of US seniors strengthens link between air pollution and premature death – Harvard T.H. Chan School of Public Health, via Science Daily (free)

Related: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)

 

5 – Childhood intelligence in relation to major causes of death in 68 year follow-up: prospective population study – The BMJ (free)

Editorial: Higher IQ in childhood is linked to a longer life (free)

Why do those with higher IQs live longer? A new study points to answers – STAT News (free) Higher childhood IQ associated with lower adult mortality – OnMedica (free) AND People with higher IQs are more likely to live to their 80s – New Scientist (free)

 

6 – Is the staggeringly profitable business of scientific publishing bad for science? – The Guardian (free)

“Interesting long read” (RT @CochraneUK see Tweet)

 

7 – Precision Medicine: the Promise vs. the Reality – Michigan University Health Lab (free) (RT @pash22)

“Scientists find great potential in using genetic sequencing to help direct targeted cancer therapy, but practicing oncologists see some important limitations”.

 

8 – Clinical Review: Update on anti-tumor necrosis factor agents and other new drugs for inflammatory bowel disease – The BMJ (free)

 

9 – Editorial: Clinical effects of antivirals for hepatitis C: context is critical – The Lancet Gastroenterology & Hepatology (free)

Original Cochrane review: Direct-acting antivirals for chronic hepatitis C – Cochrane Library (link to summary – $ for full-text)

Commentary in The Guardian: ‘Miracle’ hepatitis C drugs costing £30k per patient ‘may have no clinical effect’ (free)

 

10 – Nucleated red blood cells, critical illness survivors and postdischarge outcomes: a cohort study – Critical Care (free)

“Presence of nucleated RBCs is a robust predictor of post-discharge mortality and unplanned hospital readmission” (RT @Crit_Care see Tweet)

 

Thu, June 29 – 10 Stories of The Day!

29Jun
2017

 

1 – Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 – Journal of the American College of Cardiology (free)

Commentaries: Cardiovascular disease causes one-third of deaths worldwide – American College of Cardiology, via EurekAlert (free) AND Global Cardiovascular Disease Burden – American College of Cardiology, Latest in Cardiology (free)

 

2 – Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia – New England Journal of Medicine (free)

Commentaries: Aspirin reduces risk of pre-eclampsia in pregnant women – University of Exeter, via Science Daily (free) AND Daily Aspirin Cuts Preterm Preeclampsia in High-Risk Women – MedPage Today (free registration required)

 

3 – Free Online Course: Measuring and Valuing Health – The University of Sheffield and FutureLearn (RT @Imperial_GHD see Tweet)

“Learn how Patient Reported Outcome Measures and Quality Adjusted Life Years can compare treatments and inform healthcare spending”.

 

4 – The safety, immunogenicity, and acceptability of inactivated influenza vaccine delivered by microneedle patch (TIV-MNP 2015): a randomised, partly blinded, placebo-controlled, phase 1 trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Needle-Free Flu Vaccine Patch Works as Well as a Shot – NBC News (free) AND Microneedle Patch: Safe, Effective Flu Vaccination in First-in-Human Trial – Medscape (free registration required) AND Dissolvable patch offers radical pain-free alternative to flu injection, study finds – The Guardian (free) AND Skin patch may be the future of flu vaccines, study suggests – CNN (free text and video)

 

5 – The ABCs and Ds of Whether to Get Prostate Cancer Screening – The New York Times (10 articles per month are free)

See also the new USPSTF guidelines on prostate cancer screening and related commentaries in our April 12 issue (see #1) and in our April 13 issue (see #3)

“The upside (and downside) of prostate cancer screening” (RT @NYTHealth see Tweet)

 

6 – Stopping Pandemics Before They Start – New York Times (10 articles per month are free) (RT @wellcometrust see Tweet)

 

7 – Moisturisers improve eczema symptoms and lessen the need for corticosteroids – NIHR Signal (free)

Original Article: Emollients and moisturisers for eczema – Cochrane Library (link to summary – $ for full-text)

 

8 – A Reality Check for IBM’s AI Ambitions – MIT Technology Review (free) (RT @EricTopol see Tweet)

IBM overhyped its Watson machine-learning system, but the company still could have the best access to the kind of data needed to make medicine much smarter”.

 

9 – Cardiovascular Testing and Clinical Outcomes in Emergency Department Patients With Chest Pain – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Cardiac Tests in ED Patients Not Tied to Better Outcomes – Medscape (free registration required) AND Cardiac Testing for Slight ACS Risk Just Means More Procedures – MedPage Today (free registration required) AND Cardiac Testing in Emergency Room Chest Pain Patients – American College of Cardiology, Latest in Cardiology (free)

 

10 – Trial of Electrical Direct-Current Therapy versus Escitalopram for Depression – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: A New Brain-Stimulation Treatment Disappoints – Physician’s First Watch (free)

“For depression, new transcranial direct current stimulation treatment is not as effective as escitalopram” (RT @JWatch see Tweet)

 

Wed, June 28 – 10 Stories of The Day!

28Jun
2017

 

1 – Asthma self-management programmes can reduce unscheduled care – NIHR Signal (free)

Original article: Systematic meta-review of supported self-management for asthma: a healthcare perspective – BMC Medicine (free)

 

2 – The Impact of Whole-Genome Sequencing on the Primary Care and Outcomes of Healthy Adult Patients: A Pilot Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: In healthy patients, genome sequencing raises alarms while offering few benefits – STAT News (free) AND Whole genome sequencing not ready for routine use: study – Reuters Health News (free) AND One in five ‘healthy’ adults may carry disease-related genetic mutations – Science (free) AND Whole-Genome Sequencing Possible in Clinic, but Value Unclear – Medscape (free registration required) AND Whole-genome sequencing finds rare genetic disease risk in 1 of 5 healthy adults – ACP Internist Weekly (free)

“While some primary care physicians may be able to manage genomic information appropriately, findings could prompt increased health care use with limited clinical value, the researchers said” (from ACP)

 

3 – Blinding: A detailed guide for students – Students 4 Best Evidence (free)

“New @Students4BE blog: Saul provides a detailed overview of ‘blinding’ in RCTs. What is it & why is it important?” (RT @CochraneUK see Tweet)

 

4 – Breast Cancer Risk Assessment and Screening in Average-Risk Women – American College of Obstetricians and Gynecologists (free)

Commentary: OB/GYN Group Revises Breast Screening Recommendations for Average-Risk Women Physician’s First Watch (free)

Related guideline with a more conservative approach: Breast Cancer: Screening – U.S.Preventive Services Task Force (free)

 

5 – Improving Awareness of and Screening for Health Risks Among Sex Workers – American College of Obstetricians and Gynecologists (free)

News release: Ob-Gyn Awareness of Sex Workers’ Health Risks During Routine Visits is Essential (free)

Commentary: Group Offers Guidance on Screening for Female Sex Workers – Physician’s First Watch (free)

 

6 – Tamiflu: an expensive lesson in panic stockpiling – Dr Justin Coleman Blog (RT @pash22 see Tweet)

 

7 – WHO guidelines on ethical issues in public health surveillance – World Health Organization (free)

Commentary: Ethics of public health surveillance: new guidelines – The Lancet Public Health (free)

Public health surveillance: privacy, autonomy, equity, common good need to be balanced. New ethics guidelines” (RT @trished see Tweet)

 

8 – Report: Preventing Cognitive Decline and Dementia: A Way Forward – The National Academies of Sciences, Engineering, and Medicine (free PDF)

News Release: Evidence Supporting Three Interventions That Might Slow Cognitive Decline and the Onset of Dementia Is Encouraging but Insufficient to Justify a Public Health Campaign Focused on Their Adoption (free)

Commentaries: When it comes to preventing dementia, not much is proved to work, says expert committee – STAT News (free) AND National Academies Committee Sees Promising but Inconclusive Evidence on Interventions to Prevent Cognitive Decline, Dementia – National Institute on Aging (free)

 

9 – Consensus-based recommendations for the management of juvenile dermatomyositis – Annals of Rheumatic Diseases (free)

 

10 – Adverse Events Reported to the US Food and Drug Administration for Cosmetics and Personal Care Products – JAMA Internal Medicine (free)

Editorial: Cosmetics, Regulations, and the Public Health – Understanding the Safety of Medical and Other Products (free)

The JAMA Network – For the Media: How Many Adverse Events Are Reported to FDA for Cosmetics, Personal Care? (free)

Commentaries: More Health Problems Reported With Hair And Skin Care Products – NPR (free) AND The Hidden Dangers of Makeup and Shampoo – TIME (a few articles per month are free)

 

Tue, June 27 – 10 Stories of The Day!

27Jun
2017

 

1 – Management of Brain Arteriovenous Malformations: A Scientific Statement for Healthcare Professionals from the American Heart Association/American Stroke Association (free PDF)

Commentary: Update on the Statement on Brain AVMs: Despite New Data, Questions Still Unanswered (free)

Top Ten Things to Know: Management of Brain Arteriovenous Malformations (free PDF)

Slide Set: Management of Brain Arteriovenous Malformations (free PDF)

 

2 – Guideline summary: Consensus on Surgical Treatment of Infective Endocarditis – American College of Cardiology, Latest in Cardiology (free)

Original article: 2016 The American Association for Thoracic Surgery (AATS) consensus guidelines: Surgical treatment of infective endocarditis: Executive summary (link to abstract – $ for full-text)

 

3 – Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium Difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)

Source: EvidenceAlerts (free resource to find articles of interest)

In this meta-analysis including 19 randomized trials, probiotics given within 2 days of the first antibiotic dose (more effective than if started later) reduced the risk of Clostridium difficile infection (CDI) by >50% in hospitalized adults. 1 case of CDI would be prevented for every 23−144 patients treated with probiotics when antibiotics are started. “There was no convincing evidence of superior efficacy for any of the tested probiotic formulations, delivery methods (drink or capsule), or probiotic doses”.

 

4 – A Meta-analysis of the Impact of Aspirin, Clopidogrel, and Dual Antiplatelet Therapy on Bleeding Complications in Noncardiac Surgery – Annals of Surgery (link to abstract – $ for full-text)

Source: EvidenceAlerts (free resource to find articles of interest)

“Antiplatelet therapy at the time of noncardiac surgery confers minimal bleeding risk with no difference in thrombotic complications. In many cases, it is safe to continue antiplatelet therapy in patients with important indications for their use”

 

5 – Policy lessons from health taxes: a systematic review of empirical studies – BMC Public Health (free)

Related: Proper debate on sugar tax needed in fight against obesity and diabetes – The AGE (free)

See more on Fiscal policies for the prevention of diseases in our June 8th issue (see #4) and in our April 20th issue (see #1)

“91 studies on health taxes show they change consumption: a systematic review of empirical studies” (RT @BoydSwinburn see Tweet)

 

6 – New Choosing Wisely Canada List: Respiratory medicine: Six things physicians and patients should question (free) (RT @ChooseWiselyCA see Tweet)

See more on the Choosing Wisely initiative in our April 5 issue, see #6.

 

7 – Richard Lehman’s journal review, 26 June 2017 – The BMJ Blogs (free)

Reviews on the latest research in the top medical journals.

 

8 – Better Medicine – Shared decisions, best evidence – The BMJ

Related article: Overdiagnosis and overtreatment: generalists — it’s time for a grassroots revolution (free)

“This Better Medicine resource page builds on the work of The BMJ’s Too Much Medicine initiative and the overdiagnosis group of the RCGP in helping health professionals worldwide to share knowledge with patients and jointly make better informed choices about their care”.

 

9 – Chinese courts call for death penalty for researchers who commit fraud – STAT News (free)

Related: China cracks down on fake data in drug trials – Nature (free) 

 

10 – Viewpoint: Contact Precautions for Endemic MRSA and VRE: Time to Retire Legal Mandates – JAMA (free)

“Contact precautions are easy to use with a single patient, but burdensome when applied to an entire hospital” (RT @JAMA_current see Tweet)

This viewpoint suggests a more selective use of contact precautions for the control of endemic pathogens.

 

Mon, June 26 – 10 Stories of The Day!

26Jun
2017

 

1 – ACG and CAG Clinical Guideline: Management of Dyspepsia – American College of Gastroenterology and Canadian Association of Gastroenterology (free PDF)

 

2 – Targeted temperature management in the ICU: guidelines from a French expert panel – Annals of Intensive Care (free)

 

3 – Heart Rate and Rhythm and the Benefit of Beta-Blockers in Patients With Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Do mortality rates differ according to baseline heart rates for those taking beta-blockers? – Cardiovascular Business (free) AND Heart Rate and Rhythm and the Benefit of Beta-Blockers in Patients With Heart Failure – PracticeUpdate (free registration required)

In HFrEF, beta blockers reduce mortality – but only for those in sinus rhythm says new work in JACC” (RT @JACCJournals see Tweet)

 

4 – Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Door-to-Furosemide Time in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free) AND The Door-to-Lasix Quality Measure – Emergency Medicine Literature of Note (free)

“God help us if this sort of observational data leads to “door to furosemide time” being adopted as a quality measure” (RT @adamcifu see Tweet)

 

5 – KDIGO 2017 Clinical Practice Guideline Update for the Diagnosis, Evaluation, Prevention, and Treatment of Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) (free PDF) (RT @goKDIGO see Tweet)

Executive summary: 2017 KDIGO Chronic Kidney Disease–Mineral and Bone Disorder (CKD-MBD) Guideline Update: what’s changed and why it matters (free PDF)

News release and available resources: CKD-Mineral and Bone Disorder (CKD-MBD) (free)

 

6 – Effect of Nebulized Hypertonic Saline Treatment in Emergency Departments on the Hospitalization Rate for Acute Bronchiolitis: A Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)

Source: No Benefit of Nebulized Hypertonic Saline for Acute Bronchiolitis – Journal Watch ($ resource to find articles of interest)

Hypertonic saline clearly does not have any benefit for bronchiolitis (RT @JAMAPeds see Tweet)

 

7 – Special Issue – Homepage: Association of Coloproctology of Great Britain & Ireland (ACPGBI): Guidelines for the Management of Cancer of the Colon, Rectum and Anus (2017)

 

1 – Introduction (free)

2 – Diagnosis, Investigations and Screening (free)

3 – Surgical Management (free)

4 – Multidisciplinary Management (free)

5 – Follow Up, Lifestyle and Survivorship (free)

6 – Audit and Outcome Reporting (free)

7 – Pathology Standards and Datasets (free)

8 – Anal Cancer (free)

 

8 – Knowledge, Attitudes, and Beliefs Regarding Cardiovascular Disease in Women: The Women’s Heart Alliance – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Women and Heart Disease: New Data Reaffirm Lack of Awareness By Women and Physicians – American College of Cardiology, Latest in Cardiology (free) AND Women’s CV Risk Underestimated, Underassessed – MedPage Today (free registration required) AND Greater emphasis on preventing, treating heart disease in women needed – American College of Cardiology, via EurekAlert (free)

Related guidelines: Preventing and Experiencing Ischemic Heart Disease as a Woman: State of the Science: A Scientific Statement From the American Heart Association (free) AND Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association (free)

Women continue to underestimate their risk of cardiovascular disease.

 

9 – Host and viral traits predict zoonotic spillover from mammals – Nature (link to abstract – $ for full-text)

Commentaries: Spillover Beasts: Which Animals Pose The Biggest Viral Risk? – NPR Goats and Soda (free) (RT @NPRGoatsandSoda see Tweet with interesting illustration) AND Bats Are the Number-One Carriers of Disease – TIME Health (free) AND Where in the world will the next emerging disease appear? – CNN (free text and video) AND Bats really do harbor more dangerous viruses than other species – Science (free) AND Whence new plagues? – The Economist (a few articles per month are free)

“The majority of human emerging infectious diseases are zoonotic, with viruses that originate in wild mammals of particular concern”

 

10 – News release: Latest health evidence shows that making changes to diet, physical activity and behaviour may reduce obesity in children and adolescents – Cochrane Library (free)

Review 1: Diet, physical activity and behavioural interventions for the treatment of overweight or obese children from the age of 6 to 11 years (link to summary – $ for full-text)

Review 2: Diet, physical activity and behavioural interventions for the treatment of overweight or obese adolescents aged 12 to 17 years (link to summary – $ for full-text)

Commentary: What’s the best way for children to lose weight? Here’s what the research says – The Conversation (free)

 

Fri, June 23 – 10 Stories of The Day!

23Jun
2017

 

1 – WHO Framework on integrated people-centered health services (free resources)

Video: WHO – What is people-centered care? And why does it matter? Our new video explains! (free) (RT @WHO see Tweet)

“Integrated people-centered health services means putting the comprehensive needs of people and communities, not only diseases, at the center of health systems, and empowering people to have a more active role in their own health”.

 

2 – Cluster-Randomized, Crossover Trial of Head Positioning in Acute Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: The Head Position in Stroke Trial (free)

Commentary: Head Positioning During Early Stroke Treatment Apparently Doesn’t Affect Outcome – Physician’s First Watch (free)

 

3 – Review: Radiation Associated Cardiac Disease – American College of Cardiology, Latest in Cardiology (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)

 

4 – Why We Overrate the Lifesaving Power of Cancer Tests – Scientific American (free) (RT @EricTopol see Tweet)

 

5 – Continuous positive airway pressure for children with undifferentiated respiratory distress in Ghana: an open-label, cluster, crossover trial – The Lancet Global Health (free)

Invited commentary: Every breath you take… (free)

Commentary: CPAP improves respiratory and survival rates in children in Ghana – Columbia University’s Mailman School of Public Health, via EurekAlert (free)

 

6 – Breastfeeding and the Risk of Maternal Cardiovascular Disease: A Prospective Study of 300 000 Chinese Women – Journal of the American College of Cardiology (free)

Commentaries: Mother’s heart health tied to breastfeeding – Reuters Health (free) Does breastfeeding prevent heart disease and strokes? – STAT News (free) AND Breastfeeding could help a mother’s heart – in more ways than you think – American Heart Association News (free)

Observational data suggests there may be a protective effect.

 

7 – Cardiopulmonary resuscitation – 30:2 or just keep going? – by Scott Munro, in Evidently Cochrane (free) (RT @NIHR_DC see Tweet)

“Untrained bystander CPR had better outcomes when given telephone advice from EMS services to perform continuous CPR, rather than interrupted CPR with rescue breaths”. For trained EMS professionals, “it is possible that there is little or no difference between the two approaches”.

 

8 – An update on Zika virus infection – The Lancet (free registration required)

“Update on Zika virus infection (2017): review focuses on important updates & gaps in the knowledge” (RT @TheLancet see Tweet)

 

9 – WHO toolkit for the care and support of people affected by complications associated with Zika virus – World Health Organization (free)

 

10 – Acupuncture for analgesia in the emergency department: a multicentre, randomised, equivalence and non-inferiority trial – Medical Journal of Australia (link to abstract – Free PDF here) (RT @theMJA see Tweet)

Author commentaries: Emergency doctors are using acupuncture to treat pain, now here’s the evidence – The Conversation (free)

Positive commentaries: Acupuncture Found to Be an Effective Analgesia Option in ER – PracticeUpdate (free registration required) AND Acupuncture relieves pain in emergency patients: Study – RMIT University, via ScienceDaily (free)

“Not so fast” commentaries: Acupuncture in the ER: No, study did not prove it was ‘safe and effective’ – HealthNewsReview (free) AND A skeptical look at a study of acupuncture delivered in emergency rooms, by James C Coyne (free)

 

Thu, June 22 – 10 Stories of The Day!

22Jun
2017

 

1 – Every Newborn Action Plan – World Health Organization (free) (RT @WHO see Tweet with infographic)

Related report from UK: Each Baby Counts – Royal College of Obstetricians and Gynaecologists (free PDF) Each Baby Counts Homepage (free resources) AND Reducing baby deaths and brain injuries during childbirth – BBC News (free)

Every year, 2.7 million babies die in the first 28 days of life. 75% of these deaths are preventable.

 

2 – WHO bids goodbye to Dr Chan and celebrates her achievements – World Health Organization (Source: WHO Newsletter)

Report 1: Ten years of transformation: Making WHO fit for purpose in the 21st century (free)

Report 2: Ten years in public health 2007-2017 (free)

Report 3: Healthier, fairer, safer: the global health journey 2007–2017 (free)

Related: My decade leading the WHO: dirty fights and steps toward universal coverage – by By Margaret Chan, Via STAT News (free)

“As Dr Margaret Chan’s term as Director-General of WHO comes to an end, we’d like to share some of the successes, setbacks and enduring challenges of the past decade in global public health.”

 

3 – Your vitamin D tests and supplements are probably a waste of money – VOX (free)

Related: Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

“Screening for vitamin D has exploded — with no good evidence that it helps people.”

 

4 – Performance Improvement: Phenytoin Toxicity – JAMA (free)

Interesting case of medication error and prevention of subsequent adverse events (RT @JAMA_current see Tweet)

 

5 – Obstetrics and Gynaecology: Ten Things Physicians and Patients Should Question – Choosing Wisely (free) (RT @ChooseWiselyCA see Tweet)

“New Choosing Wisely recommendations list! @SOGCorg identifies 10 tests, treatments to question in obstetrics and gynecology

 

6 – ACR Thyroid Imaging, Reporting and Data System (TI-RADS): White Paper of the ACR TI-RADS Committee – Journal of the American College of Radiology (free, and legal, PDF via Unpawall)

Commentary: New ultrasound scoring system for thyroid nodules to reduce unnecessary biopsies – University of Alabama at Birmingham, via EurekAlert (free)

 

7 – Harnessing the Power of Data in Health – Stanford Medicine 2017 Health Trends Report (free PDF)

News release: Stanford Medicine launches health care trends report (free)

“Stanford Medicine launches report on health care trends” (RT @StanfordMed see Tweet)

 

8 – A medicine review is about stopping medicine as much as it is about prescribing – Royal Pharmaceutical Society of Great Britain (free) (RT @MaryanneDemasi see Tweet)

Original report: The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF)

Related: Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)

 

9 – Is aircraft noise exposure associated with cardiovascular disease and hypertension? Results from a cohort study in Athens, Greece – Occupational and Environmental Medicine (link to abstract – $ for full-text)

Commentaries: Noise May Raise Blood Pressure Risk – New York Times (10 articles per month are free) AND Long term exposure to aircraft noise linked to high blood pressure – The BMJ, via EurekAlert (free) AND Live Near an Airport? Nighttime Airplane Noise May Cause Hypertension – Medscape (free registration required)

Cohort study suggests a possible association.

 

10 – EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome (free)

Commentary: EULAR: Guidance for Managing Lupus Pregnancy – MedPage Today (free registration required)

 

Wed, June 21 – 10 Stories of The Day!

21Jun
2017

 

1 – Colorectal cancer screening: Recommendations for physicians and patients from the U.S. Multi-Society Task Force on Colorectal Cancer – Gastrointestinal Endoscopy (free)

Commentaries: Task Force presents new ranking of colorectal cancer screening tests – American Society of Gastrointestinal Endoscopy, via EurekAlert (free) AND Latest Colorectal Cancer Screening Guidelines – Latest Colorectal Cancer Screening Guidelines – GI and Hepatology News (free)

Related: Colorectal Cancer Screening – U.S. Preventive Services Task Force (free)

 

2 – Screening for Obesity in Children and Adolescents: US Preventive Services Task Force Recommendation Statement (free)

Editorial 1: Putting the US Preventive Services Task Force Recommendation for Childhood Obesity Screening in Context (free)

Editorial 2: Practical Considerations for the US Preventive Services Task Force Recommendations on Obesity in Children and Adolescents (free)

Author interview: USPSTF Recommendation: Screening for Obesity in Children and Adolescents (free audio)

The JAMA Network – for the media: Screening for Obesity in Children and Adolescents Recommended (free)

Commentary: USPSTF Recommends Screening For Obesity in Children and Adolescents – American College of Cardiology, Latest in Cardiology (free)

“The USPSTF recommends that clinicians screen for obesity in children and adolescents 6 years and older and offer or refer them to comprehensive, intensive behavioral interventions to promote improvements in weight status”

 

3 – The Evidence-Based Medicine Manifesto for Better Healthcare – Centre for Evidence-Based Medicine, University of Oxford (free)

 

4 – Review: Differentiating lower motor neuron syndromes – Journal of Neurology, Neurosurgery, and Psychiatry – Journal of Neurology, Neurosurgery, and Psychiatry (free)

 

5 – Antiplatelet Therapy in Patients With Coronary Stents Undergoing Elective Noncardiac Surgery: Continue, Stop, or Something in Between? – JAMA (free)

 

6 – Risks of Breast, Ovarian, and Contralateral Breast Cancer for BRCA1 and BRCA2 Mutation Carriers – JAMA (link to abstract – $ for full-text)

The JAMA Network – For the media: Study Estimates Age-Specific Overall Risk of Breast, Ovarian Cancer among Women with BRCA1/2 Genetic Mutations (free)

Commentary: Risk for Breast and Ovarian Cancer in BRCA1 and BRCA2 Mutation Carriers: Refining Our Estimates – Physician’s First Watch (free)

 

7 – Taxing sugary drinks would boost productivity, not just health – The Conversation (free)

Original article: The impact on productivity of a hypothetical tax on sugar-sweetened beverages – Health Policy (link to abstract – $ for full-text)

See more on the potential benefits of sugar taxes in our June 8th issue (see #4) and in our April 20th issue (see #1)

 

8 – Yoga, Physical Therapy, or Education for Chronic Low Back Pain: A Randomized Noninferiority Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Yoga Vs. Physical Therapy For Chronic Low Back Pain: Which Is More Effective? – Forbes (free) AND Yoga Noninferior to Physical Therapy for Low Back Pain – Physician’s First Watch (free) AND Yoga as Good for Low Back Pain as Physical Therapy – Medscape (free registration required)

 

9 – Levocetirizine and Prednisone Are Not Superior to Levocetirizine Alone for the Treatment of Acute Urticaria: A Randomized Double-Blind Clinical Trial – Annals of Emergency Medicine (free)

Commentaries: No Benefit From Corticosteroids for Acute, Simple Urticaria – Medscape (free registration required) AND Got hives? Hold the steroids – American College of Emergency Physicians, via EurekAlert (free)

 

10 – Can Zika infection attack the brains of newborns? Scientists head to field for answers – STAT News (free)

Related: Is Zika Dangerous For Kids? It Probably Depends On The Age – NPR Goats and Soda (free)

 

Tue, June 20 – 10 Stories of The Day!

20Jun
2017

 

1 – Glucose targets for preventing diabetic kidney disease and its progression – Cochrane Library (link to summary – $ for full review)

Sources: EvidenceAlerts and @anupam1623

Intensive glycemic control had no effect on risks of kidney failure, death and major cardiovascular events. “The clinical impact of targeting an HbA1c < 7% or blood glucose < 6.6 mmol/L (120 mg/dL) is unclear and the potential harms of this treatment approach are largely unmeasured.”

 

2 – Evidence for Therapeutic Patient Education Interventions to Promote Cardiovascular Patient Self-Management: A Scientific Statement for Healthcare Professionals From the American Heart Association (free)

News Release: Healthcare providers should individualize patient education (free)

AHA statement: Doctors’ orders should include tailored health education for patients (free)

Commentary: Sharpening the Focus on Therapeutic Patient Education and Self-management (free)

Top Ten Things to Know: Evidence for Therapeutic Patient Education Interventions to Promote Cardiovascular Patient Self-Management (free PDF)

 

3 – Effect of antibiotic stewardship on the incidence of infection and colonisation with antibiotic-resistant bacteria and Clostridium difficile infection: a systematic review and meta-analysis – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Antibiotic Stewardship Programs Linked to Lower Rates of Drug-Resistant Infections – Physician’s First Watch (free) AND Review ties stewardship to sharp drop in resistant bacteria – CIDRAP (free)

 

4 – Reducing Cancer Burden in the Population: An Overview of Epidemiologic Evidence to Support Policies, Systems, and Environmental Changes – Epidemiologic Reviews (free)

 

5 – Treating patients with opioid disorders is not just about treating addiction. Here’s why – STAT News (free)

Original analysis: What data from 205 million private health insurance claims reveals about America’s opioid crisis – Amino (free)

 

6 – Alterations in Cardiac Deformation, Timing of Contraction and Relaxation, and Early Myocardial Fibrosis Accompany the Apparent Recovery of Acute Stress-Induced (Takotsubo) Cardiomyopathy: An End to the Concept of Transience – Journal of the American Society of Echocardiography (link to abstract – $ for full-text)

Commentaries: Broken heart syndrome may have lasting damage, say researchers – BBC Health News (free) AND Broken heart syndrome may cause permanent damage – News Medical (free) AND ‘Octopus pot’ syndrome: why a broken heart can be as bad as cardiac arrest – The Guardian (free)

 

7 – Changes in Hospital Quality Associated with Hospital Value-Based Purchasing – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Value-Based Purchasing Program Has Little Effect – Medscape (free registration required) AND Is There Value in Hospital Value-Based Purchasing? – NEJM Catalyst (free)

How VBP works: Hospital Value-Based Purchasing – U.S. Centers for Medicare & Medicaid Services (free)

 

8 – Richard Lehman’s weekly review of medical journals, 19 June 2017 – The BMJ Blogs (free)

 

9 – The Science Behind How Nature Affects Your Health – Forbes (free)

“100% agree: Social determinants of health have a far greater impact on our health than healthcare delivery systems” (RT @SueDHellmann see Tweet)

 

10 – Inspired by War Zones, Balloon Device May Save Civilians From Fatal Blood Loss – The New York Times (10 articles per month are free)

 

Mon, June 19 – 10 Stories of The Day!

19Jun
2017

 

1 – Comparison of sputum collection methods for tuberculosis diagnosis: a systematic review and pairwise and network meta-analysis – The Lancet Global Health (free)

Invited commentary: Remembering the basics: interventions to improve sputum collection for tuberculosis diagnosis (free)

Pooled sputum collection (sputum that was pooled from each spontaneous expectoration into the same sputum container over a period of several hours) increased the diagnostic performance of smear microscopy 1.6 times and the delivery of standardized instruction emphasizing the difference between sputum and saliva (verbally or visually) increased the odds of a positive microscopy result 1.4 times. “The effect of these simple, inexpensive strategies on diagnostic performance was similar to that of the relatively expensive GeneXpert MTB/RIF test, which, in the largest published studies, increased the odds of diagnosing tuberculosis by 1.3–1.5 times”

 

2 – Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association (free PDF)

Invited Commentary: Trimming the Fat on Diet Recommendations for a Healthy Heart: Emphasis on Eating Patterns over Dietary Restrictions (free)

Top Ten Things to Know: Dietary Fats and Cardiovascular Disease: A Presidential Advisory from the American Heart Association (free PDF)

AHA News: Advisory: Replacing saturated fat with healthier fat could lower cardiovascular risks (free)

News release: Replacing saturated fat with healthier fat may lower cholesterol as well as drugs in context of a healthy diet (free)

AHA no longer recommends decreasing total fat, but to replace saturated fats with polyunsaturated or monounsaturated fats. “Replacing saturated fat with healthier fat in the diet lowers cardiovascular disease risk as much as cholesterol-lowering statin drugs”

 

3 – Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer: cohort study – The BMJ (free)

Commentary: New web calculator to more accurately predict bowel cancer survival – University of Nottingham, via EurekAlert (free)

See also: QCancer-2017(colorectal, survival) risk calculator (free risk calculator based on the data)

 

4 – Racial Differences in the Relationship of Glucose Concentrations and Hemoglobin A1c Levels – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Glycation of Hemoglobin Differs by Race – Physician’s Briefing (free) AND Hemoglobin A1c Overestimates Average Glucose in Blacks – Medscape (free registration required) AND Why a key diabetes test may work differently depending on your race – CNN (free)

In this study with 104 black patients and 104 white patients with type 1 diabetes, HbA1c values in black persons were 0.4 percentage points higher than those in white persons for a given mean glucose concentration.

 

5 – Free online course. Starts today! Improving the Health of Women, Children and Adolescents: from Evidence to Action – London School of Hygiene & Tropical Medicine, via FutureLearn (free)

 

6 – 2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty (free)

Press release: New Guideline Aims to Reduce Infections in Total Hip & Knee Replacement Patients (free)

Commentaries: New medication guidelines for rheumatic disease patients having joint replacement – Hospital for Special Surgery, via EurekAlert (free) AND New Guidelines Issued on Antirheumatic Drugs for Patients Undergoing Knee or Hip Replacement – Physician’s First Watch (free)

 

 

7 – What If (Almost) Every Gene Affects (Almost) Everything? – The Atlantic (free) (RT @AllenFrancesMD see Tweet)

 

8 – Evolocumab for Treatment of High Cholesterol: Clinical Effectiveness (free PDF) (RT @AnilMakam see Tweet 1, Tweet 2, Tweet 3 and Tweet 4)

News release: Institute for Clinical and Economic Review’s “New Evidence Update” on PCKS9 Inhibitors Highlights Lack of Mortality Benefit With Evolocumab (free)

Lack of mortality benefit in a recent large trial is highlighted in this updated review. Se more on the FOURIER trial and commentaries in our March 20th issue, see #2.

 

9 – Why are doctors killing themselves? – by Anne Malatt, via MJA Insight (free)

Related: Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT News (free)

 

10 – EULAR/EFORT recommendations for management of patients older than 50 years with a fragility fracture and prevention of subsequent fractures (free)

 

Fri, June 16 – 10 Stories of The Day!

16Jun
2017

 

1 – World Elder Abuse Awareness Day (June 15, 2017)

WHO News release: Abuse of older people on the rise – 1 in 6 affected – World Health Organization (free)

See also:  Elder abuse fact sheet (free) AND WHO’s work on elder abuse (free) AND World report on ageing and health (free)

Related: Elder abuse prevalence in community settings: a systematic review and meta-analysis – The Lancet Global Health (free) AND Protecting the global longevity dividend – The Lancet Global Health (free)

 

2 – OpenWHO – The World Health Organization launched a series of video courses on epidemics, pandemics & health emergencies, open to the public (free courses and videos) (RT @WHO see Tweet)

 

3 – A randomized trial of telemedicine efficacy and safety for nonacute headaches – Neurology (free) (RT @EricTopol see Tweet)

Commentary: For Headache, Telemedicine May Be as Effective as in-Person – American Academy of Neurology, via NewsWise (free)

 

4 – New Choosing Wisely List: American Society of Health-System Pharmacists – Five Things Physicians and Patients Should Question (free)

See more on the Choosing Wisely initiative in our April 5 issue, see #6.

“Great choosing wisely list from @ASHPOfficial. Great doctoring tips for physicians & trainees” (RT @AnilMakam see Tweet)

 

5 – Doctors are prone to burn-out and depression. We need to take care – World Economic Forum (free)

 

6 – Pharmacological treatments and risk of readmission to hospital for unipolar depression in Finland: a nationwide cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary: Lithium Markedly Cuts Hospital Readmission in Depression – Medscape (free registration required)

 

7 – Review: Pathophysiology of Takotsubo Syndrome – Circulation (free)

 

8 – Risk of major congenital malformations in relation to maternal overweight and obesity severity: cohort study of 1.2 million singletons – The BMJ (free)

Commentaries: Risks of major birth defects greater if mother is overweight – OnMedica (free) AND Obese women more likely to have babies with serious birth defects, says study – The Guardian (free)

 

9 – Machine Learning Versus Standard Techniques for Updating Searches for Systematic Reviews: A Diagnostic Accuracy Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Artificial intelligence may help doctors keep up with new research – Reuters (free)

“Machine-learning fed by citations of a systematic saved a ton of time for updating it, didn’t miss important studies” (RT @hildabast see Tweet)

 

10 – Opinion: Too much medical care: bad for you, bad for health care systems – STAT News (free)

 

Thu, June 15 – 10 Stories of The Day!

15Jun
2017

 

1 – World Blood Donor Day (June 14, 2017) – World Health Organization (free)

See also: 10 facts on blood transfusion (free) AND Giving blood in a time of crisis (free) AND WHO’s work on blood transfusion safety (free)

 

2 -Time to Delivery of an Automated External Defibrillator Using a Drone for Simulated Out-of-Hospital Cardiac Arrests vs Emergency Medical Services – JAMA (link to abstract – $ for full-text)

The JAMA Network – For the Media: Can Use of a Drone Improve Response Times for Out-Of-Hospital Cardiac Arrests Compared to an Ambulance? (free)

Commentaries: Drones Can Get Defibrillators to Bystanders Faster Than EMS Can – Physician’s First Watch (free) AND Defibrillator Drones Can Reach You Four Times Faster Than EMS – ECN (free)

In 18 simulated cases in Sweden, the drones could get automatic external defibrillators to the scene an average of 16 minutes faster than emergency medical services.

 

3 – 6 Ways Drones Could Change Health Care – Scientific American (free)

 

4 – Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentary: NOAC Doses: Just Stick to the Label – MedPage Today (free registration required)

“Among the 1,473 patients with a renal indication for dose reduction, 43.0% were potentially overdosed, which was associated with a higher risk of major bleeding”

 

5 – Hospitals Are Dramatically Overpaying for Their Technology – Harvard Business Review (a few articles per month are free)

“For years, hospitals have invested in sophisticated devices and IT systems that, on their own, can be awe-inspiring. Yet these technologies rarely share data, let alone leverage it to support better clinical care”.

 

6 – Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

The JAMA Network – For the Media: Treating Nutritional Iron-Deficiency Anemia in Children (free)

Commentaries: Ferrous Sulfate Drops Tied to Higher Hemoglobin Increases in Kids with Anemia – Physician’s First Watch (free) AND Traditional treatment is better for iron-deficiency anaemia in children – OnMedica (free) AND Ferrous Sulfate Effective for Iron-Deficiency Anemia in Kids – Medscape (free registration required)

Researchers expected that Iron Polysaccharide Complex would restore hemoglobin more effectively, because it is designed to be tolerated better, but the proportion of infants and children with a complete resolution of iron-deficiency anemia was higher in the ferrous sulfate group (29 percent vs 6 percent).

 

7 – Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events: a population-based cohort study – The Lancet (free)

Invited commentary: Preventing major gastrointestinal bleeding in elderly patients (free)

Commentaries: Aspirin Bleeding Risk in Over 75s Higher Than Thought – Medscape (free registration required) AND Aspirin linked to higher risk of serious bleeding in the elderly – Reuters Health News (free)

In this cohort, the risk of major bleeding increased sharply in patients above 75 years.

 

8 – Reframing non-communicable diseases as socially transmitted conditions – The Lancet Global Health (free)

“Socially transmitted conditions”: a new name for non-communicable diseases (RT @LancetGH see Tweet)

 

9 – Essential medicines require essential diagnostics – The Huffington Post Canada Blogs (free)

See more about the new WHO list of essential medicines in our June 7th issue, see #1.

“To use essential medicines, have to know what you’re treating says @paimadhu so need essential diagnostics list too” (RT @markcha see Tweet)

 

10 – Real-World Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of 29 823 Patients With Schizophrenia – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Oral clozapine, long-acting injectables tied to lower relapse risk in schizophrenia – Clinical Psychiatry News (free registration required) AND Long-Acting Antipsychotics Tied to Superior Outcomes – Medscape (free registration required)

“The risk of rehospitalization is about 20% to 30% lower during long-acting injectable treatments compared with equivalent oral formulations”

 

Wed, June 14 – 10 Medical Stories of The Day!

14Jun
2017

 

1 – Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes – New England Journal of Medicine (free)

Commentary: CANVAS: Canagliflozin Reduces CV Events, but at Cost of Amputations – Medscape (free registration required)

Patients treated with canagliflozin had a lower risk of cardiovascular events than those who received placebo but a greater risk of amputation and fractures. The benefits and harms were likely small. See interesting commentaries on the trade-offs by @AnilMakam, see Tweet 1; Tweet 2; Tweet 3; Tweet 4; Tweet 5; Tweet 6; Tweet 7; Tweet 8; and Tweet 9.

 

2 – The End of Human Doctors – The Bleeding Edge of Medical AI Research (Part 1) – By Luke Oakden-Rayner (RT @pash22 see Tweet)

Original article: Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs – JAMA (free)

See more on the impact of artificial intelligence in healthcare in our April 28th issue, see #1, and in our April 10th issue, see #8

 

3 – The End of Human Doctors – The Bleeding Edge of Medical AI Research (Part 2) – By Luke Oakden-Rayner (RT @pash22 see Tweet)

Original article: Dermatologist-level classification of skin cancer with deep neural networks – Nature (link to abstract – $ for full-text)

See more on the impact of artificial intelligence in healthcare in our April 28th issue, see #1, and in our April 10th issue, see #8

 

4 – Association of Adverse Events With Antibiotic Use in Hospitalized Patients – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Antibiotic-Associated Adverse Events Common – Medscape (free registration required)

“20% of hospitalized patients receiving antibiotics had adverse drug event. Of those, 20% of regimens inappropriate” (RT @PeterPronovost see Tweet)

 

5 – Medical News & Perspectives: More Treatments on Deck for Alcohol Use Disorder – JAMA (free)

 

6 – Association Between Persistent Pain and Memory Decline and Dementia in a Longitudinal Cohort of Elders – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Persistent Pain May Increase Dementia Risk – The New York Times (10 articles per month are free)

Cohort of community-dwelling older adults suggests there might be a link.

 

7 – Snakebite finally makes a WHO list of top global health priorities – STAT News (free)

 

8 – How to fall to your death and live to tell the tale – Mosaic Science (free)

“Falls—such as slipping in the shower or tripping down stairs—kill over 420,000 people worldwide each year” (RT @ghn_news see Tweet)

 

9 – A Test in Context: Fractional Flow Reserve: Accuracy, Prognostic Implications, and Limitations – Journal of The American College of Cardiology (link to abstract – $ for full-text)

10 key points to remember: FFR: Accuracy, Prognostic Implications, and Limitations – American College of Cardiology, Latest in Cardiology (free)

 

10 – Combination inhaler treatment in emergency departments may reduce admissions for asthma attacks – NIHR Signal (free)

Original article: Combined inhaled beta-agonist and anticholinergic agents for emergency management in adults with asthma – Cochrane Library (link to abstract – $ for full-text)

 

Mon, June 12 – 10 Medical Stories of The Day!

12Jun
2017

 

1 – New Series from The Lancet: Health in Humanitarian Crises (free registration required)

Related: How to Fix the Broken Humanitarian System: A Q&A with Paul Spiegel – Global Health NOW (free)

“Evidence is important to guide more effective & efficient health responses in humanitarian contexts” (RT @TheLancet see Tweet)

 

2 – Glucose Self-monitoring in Non–Insulin-Treated Patients With Type 2 Diabetes in Primary Care Settings: A Randomized Trial – JAMA Internal Medicine (free)

Editorial: The Need to Test Strategies Based on Common Sense (free)

The JAMA Network – For the Media: Home Monitoring of Blood Sugar Did Not Improve Glycemic Control After 1 Year (free)

Commentary: Is the finger-stick blood test necessary for type 2 diabetes treatment? – University of North Carolina Health Care, via EurekAlert (free)

Related: Self-Monitoring of Blood Glucose – Canadian Agency for Drugs and Technologies in Health (free)

“Another RCT showing no benefit for Glucose Self-monitoring in Non–Insulin-Treated Patients with Type 2 Diabetes” (RT @PaulGlasziou see Tweet)

 

3 – Prevention of acute kidney injury and protection of renal function in the intensive care unit: update 2017 – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

 

4 – Palliative care: A pathway to value-based care for nursing homes – Diane E. Meier, M.D via McKnight (free)

 

5 – ‘How long have I got?’: Why many cancer patients don’t have answers – USA Today (free)

Related: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

See more on Standardized Criteria for Palliative Care Consultation in our April 24 issue, see #8

“ASCO now recommends that everyone with advanced cancer receive palliative care within eight weeks of diagnosis.” (RT @cancerassassin1 see Tweet)

 

6 – Diagnosis and management of dementia with Lewy bodies – Neurology (free)

Commentary: New International Guidelines Issued on Dementia with Lewy Bodies – Mayo Clinic, via NewsWise (free)

 

7 – Timing of food introduction and development of food sensitization in a prospective birth cohort – Pediatric Allergy and Immunology (link to abstract – $ for full-text)

Commentary: Delayed food introduction may increase likelihood of allergy in later childhood – McMaster University, via News Medical (free)

 

8 – Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors Versus Other Glucose-Lowering Drugs: The CVD-REAL Study – Circulation (free PDF)

Commentaries: Risk of HF and Death in Patients on SGLT-2 Inhibitors – American College of Cardiology, Latest in Cardiology (free) AND SGLT2 inhibitors may have class effect for reduction of cardiac risk – ACP Diabetes Monthly (free)

Observational data suggests these class of drugs may be associated with lower risk of heart failure and deaths compared to other drugs.

 

9- Canagliflozin will receive new boxed warning about amputation risks – ACP Internist (free)

FDA Drug Safety Communication: FDA confirms increased risk of leg and foot amputations with the diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) (free)

 

10 – Working with influenza-like illness: Presenteeism among US health care personnel during the 2014-2015 influenza season – American Journal of Infection Control (link to abstract – $ for full-text)

Commentaries: Working while sick – ACP Internist (free) AND Health worker survey reveals many work during flu illness – CIDRAP (free)

Over 40% of surveyed health care personnel worked with self-reported influenza-like illness. “To reduce levels of health-worker–associated flu transmission, the researchers said that misconceptions about working while sick and sick leave policies both need to be addressed” (from CIDRAP)

 

Tue, June 13 – 10 Medical Stories of The Day!

13Jun
2017

 

1 – Health Effects of Overweight and Obesity in 195 Countries over 25 Years – New England Journal of Medicine (free)

Editorial: Global Health Effects of Overweight and Obesity (free)

Commentaries: New study finds more than 2 billion people overweight or obese – Institute for Health Metrics and Evaluation (free) AND More Than 10 Percent of World’s Population Is Obese, Study Finds – The New York Times (free) AND Being overweight – not just obese – kills millions a year, say experts – The Guardian (free)

“High BMI accounted for 4.0 million deaths globally, nearly 40% of which occurred in persons who were not obese”

 

2 – Improving Recognition of Pediatric Severe Sepsis in the Emergency Department: Contributions of a Vital Sign–Based Electronic Alert and Bedside Clinician Identification – Annals of Emergency Medicine (free)

Editorial: Between the Devil and the Deep Blue Sea: Use of Real-Time Tools to Identify Children With Severe Sepsis in the Pediatric Emergency Department (free)

Commentary: New pediatric protocol reduces missed sepsis diagnoses by 76 percent – American College of Emergency Physicians, via EurekAlert (free)

 

3 – Strategies for Preventing HIV Infection Among HIV-Uninfected Women Attempting Conception with HIV-Infected Men – CDC/MMWR (free)

Commentaries: CDC Outlines Options for HIV-Discordant Couples Who Want to Conceive – Physician’s First Watch (free) AND CDC Reversal: Sperm From HIV-Infected Men Okay for Insemination – Medscape (free registration required)

 

4 – It’s time to get serious about the safety of medical devices – STAT News (free)

 

5 – The 2017 Focused Update of the Guidelines of the Taiwan Society of Cardiology (TSOC) and the Taiwan Hypertension Society (THS) for the Management of Hypertension (free)

 

6 – Kidney Cancer, Version 2.2017, NCCN Clinical Practice Guidelines in Oncology (free)

 

7 – Guidelines for the recognition and management of mixed depression – CNS Spectrums (free)

Commentary: First-Ever Guideline for Mixed Depression Released – Medscape (free registration required)

 

8 – Richard Lehman’s weekly review of medical journals, 12 June 2017 – The BMJ Blogs (free)

 

9 – Conflicts of interest in health care journalism. Who’s watching the watchdogs? We are. Part 1 of 3 – HealthNewsReview (free)

 

10 – Drugs may help people pass larger kidney stones – NIHR Signal (free)

Original article: Alpha blockers for treatment of ureteric stones: systematic review and meta-analysis – The BMJ (free)

 

Fri, June 9 – 10 Medical Stories of The Day!

9Jun
2017

 

1 – Head injury: assessment and early management – NICE Guideline (free)

 

2 – Are Small Breast Cancers Good because They Are Small or Small because They Are Good? – New England Journal of Medicine (no abstract available – $ for full-text)

Commentaries: Some Small Tumors In Breasts May Not Be So Bad After All – NPR Health News (free) AND Mammograms: Are we overdiagnosing small tumors? – Yale University, via MedicalXpress (free) AND With Breast Cancer, the Best Treatment May Be No Treatment – Wired (free)

See a related article and commentaries on Mammography and Overdiagnosis in our October 14th, 2016 issue, see #1 and #2.

 

3 – Completion Dissection or Observation for Sentinel-Node Metastasis in Melanoma – New England Journal of Medicine (link to abstract – $ for full-text)

Quick take video summary: Dissection or Observation for Sentinel-Node Metastasis (free)

Commentaries: Watch-and-Wait OK in Sentinel Node Positive Melanoma – MedPage Today (free registration required) AND Common Surgical Treatment for Melanoma Does Not Improve Patients’ Overall Survival, Study Shows – Cedars-Sinai Medical Center, via NewsWise (free)

 

4 – 2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis (free)

Commentary: ACR Releases Guideline on prevention & treatment of glucocorticoid-induced osteoporosis – American College of Rheumatology, via EurekAlert (free)

 

5 – Practice Guidelines for Preoperative Fasting and the Use of Pharmacologic Agents to Reduce the Risk of Pulmonary Aspiration – Anesthesiology, via Medscape (free registration required)

 

6 – Risk of Diabetic Ketoacidosis after Initiation of an SGLT2 Inhibitor – New England Journal of Medicine (free)

Commentaries: Study Warns of Diabetic Ketoacidosis With SGLT2 Inhibitors in T2D – MedPage Today (free registration required) AND SGLT2 Inhibitors Double the Risk for Diabetic Ketoacidosis – Medscape (free registration required) AND New class of type 2 diabetes drug associated with rare, life-threatening outcome – Brigham and Women’s Hospital, Via EurekAlert (free)

Related: SGLT2 inhibitors and diabetic ketoacidosis: data from the FDA Adverse Event Reporting System – Diabetologia (link to abstract – $ for full-text)

 

7 – Precision Oncology: Who, How, What, When, and When Not? – ASCO Educational Book (free) (RT @pash22)

See also: 2017 ASCO Educational Book – full volume (free)

 

8 – Hope and hype around cancer immunotherapy – CNN (free)

 

9 – Cervical stitch (cerclage) for preventing preterm birth in singleton pregnancy – Cochrane Library (link to abstract – $ for full-text)

“Cervical cerclage reduces the risk of preterm birth in women at high-risk of preterm birth and probably reduces risk of perinatal deaths”

 

10 – Income and Cancer Overdiagnosis: When Too Much Care Is Harmful – New England Journal of Medicine (no abstract available – $ for full-text)

Commentary: Are wealthier people more likely to receive a diagnosis of cancer? – Dartmouth Institute for Health Policy and Clinical Practice, via EurekAlert (free)

 

Thu, June 8 – 10 Medical Stories of The Day!

8Jun
2017

 

1 – Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline: longitudinal cohort study – The BMJ (free)

Editorial: Alcohol consumption and brain health (free)

Commentaries: Even moderate drinking linked to a decline in brain health, finds study – Oxford’s Department of Psychiatry (free) AND Moderate drinking may alter brain, study says – CNN (free) AND Even moderate drinking may speed brain decline – STAT News (free) AND Even moderate drinking linked to changes in brain structure, study finds – Reuters (free)

 

2 – Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies – The BMJ (free)

Observational studies suggest that high serum uric acid levels are associated with multiple health outcomes, including cardiovascular and metabolic diseases. This review findings suggest there is a clear association only for gout and nephrolithiasis.

 

3 – The opioid crisis changed how doctors think about pain – VOX (free)

“One of the expectations our patients have is that pain can be completely eliminated. We as a medical community are coming to an understanding that this is not realistic.” (RT @KariTikkinen and @voxdotcom and see Tweet)

 

4 – Reducing US cardiovascular disease burden and disparities through national and targeted dietary policies: A modelling study – PLOS Medicine (free)

Commentaries: Change in USA food policies could prevent 230,000 heart disease deaths by 2030 – Imperial College of London (free) AND U.S. nutrition policies may cut heart disease and save lives – Reuters Health News (free)

Related: Taxes and Subsidies for Improving Diet and Population Health in Australia: A Cost-Effectiveness Modelling Study – PLOS Medicine (free) AND The US had no soda taxes in 2013. Now nearly 9 million Americans live with them – VOX (free)

“Increased discounts on fruit and vegetables, and higher taxes on sugary drinks, could prevent heart disease deaths, says a new study” (from Imperial College of London commentary)

 

5 – Perspective: Cyberattack on Britain’s National Health Service: A Wake-up Call for Modern Medicine – New England Journal of Medicine (free)

Related: 11 Things the Health Care Sector Must Do to Improve Cybersecurity – Harvard Business Review (free) AND Eric D Perakslis: Cyber security modeled as infection prevention and control in the healthcare delivery setting – The BMJ Opinion (free) AND Healthcare Seen Highly Vulnerable to Cyberattack – MedPage Today (free registration required)

 

6 – Current and future perspectives on the management of polypharmacy – BMC Family Practice (free) (RT @Azeem_Majeed see Tweet)

 

7 – Handshake-free zone in a neonatal intensive care unit: Initial feasibility study – American Journal of Infectious Control (link to abstract – $ for full-text)

Commentaries: Hospitals Could One Day Be Handshake-Free Zones To Prevent The Spread Of Disease – WBGH News (free) AND Handshake-Free Zone: Stopping the Spread of Germs in the Hospital – Medscape (free registration required) AND Handshake-Free Zones Target Spread Of Germs In The Hospital – NPR Health News (free)

 

8 – Association of Gestational Weight Gain With Maternal and Infant Outcomes: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: RCOG statement on gestational weight gain or loss and adverse outcomes – Royal College of Obstetricians and Gynaecologists (free) AND Weight gain greater, less than recommended during pregnancy linked with increased risk of adverse outcomes – The JAMA Network Journals, via EurekAlert (free) AND Pregnancy Weight Gain Status Tied to Adverse Outcomes – MedPage Today (free registration required) AND Gaining Too Much, Too Little Weight in Pregnancy Tied to Adverse Outcomes for Mother, Baby – Physician’s First Watch (free) AND Global study finds 75% of pregnant women don’t have healthy weight gain – The Guardian (free)

 

9 – Pelvic floor exercises may reduce need for further treatments for pelvic organ prolapse – NIHR Signal (free)

Original article: Pelvic floor muscle training for secondary prevention of pelvic organ prolapse (PREVPROL): a multicentre randomised controlled trial – The Lancet (link to abstract – $ for full-text)

 

10 – Eggs in Early Complementary Feeding and Child Growth: A Randomized Controlled Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Eggs Significantly Increase Growth in Young Children – Washington University in St. Louis, via NewsWise (free) AND An egg a day appears to help young children grow taller – BBC Health News (free)

“Surpassing previous research, study finds eggs are more viable nutrition, better intervention for children in developing countries” (from NewsWise)

 

Wed, June 7 – 10 Medical Stories of The Day!

7Jun
2017

 

1 – News release: WHO updates Essential Medicines List with new advice on use of antibiotics, and adds medicines for hepatitis C, HIV, tuberculosis and cancer (free)

Report 1: The 2017 Expert Committee on the Selection and Use of Essential Medicines (free PDF)

Report 2: WHO Model List of Essential Medicines (free PDF)

Report 3: WHO Model List of Essential Medicines for Children (free PDF)

Commentaries: WHO creates controversial ‘reserve’ list of antibiotics for superbug threats – The Washington Post (free) AND Health officials set to release a list of drugs everyone on Earth should be able to access – STAT News (free) AND WHO’s New Essential Medicines List Includes a 40-Year First – Medscape (free registration required)

WHO Essential Medicines List is used by many countries to guide decisions regarding which medications should be available for their population.

 

2 – Pharmacologic Management of Newly Detected Atrial Fibrillation: Updated clinical practice guideline:  – American Academy of Family Physicians (free PDF)

Key Recommendations: Pharmacologic Management of Newly Detected Atrial Fibrillation (free)

 

3 – #ASCO2017 (Unpublished results) – Risk-Based Approach to Chemotherapy Duration Recommended for Stage III Colon Cancer – ASCO Daily News (free) AND ASCO2017:The IDEA Collaboration: Global Study Sets New Risk-Based Standard to Personalize Chemotherapy for Colon Cancer After Surgery – ASCO Post (free)

Commentaries: Chemo Cut in Half Following Surgery Without Increased Recurrence Risk in Patients With Low-Risk Colon Cancer – Targeted Oncology (free) Less Is More: Patients With Colon Cancer Get a Chemo Break – Medscape (free registration required) Cutting Chemo Time in Low-Risk Colon Ca an Option – MedPage Today (free registration required)

 

4 – #ASCO2017 (Unpublished results) – Pregnancy After Breast Cancer Does Not Increase Chance of Recurrence – ASCO News Releases (free)

Commentaries: Yes, a Pregnancy After Breast Cancer Is Safe – Medscape (free registration required) AND Pregnancy after breast cancer doesn’t raise recurrence risk – Reuters Health News (free) AND Pregnancy After Breast Cancer Does Not Increase Recurrence Risk – Oncology Times (free)

 

5 – Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis: Systematic Review and Meta-analysis of Controlled Trials – Annals of Surgery (link to abstract – $ for full-text)

Commentary: Antibiotics Versus Surgery: Equally Effective in Treating Appendicitis? – Medscape (free registration required)

This meta-analysis and the author’s conclusions do not favor antibiotics alone for the treatment of uncomplicated appendicitis, contradiction the results of other recent meta-analysis, as well as a recent guideline on the subject, suggesting antibiotics might be an option in selected cases.

 

6 – BSACI guideline for the diagnosis and management of peanut and tree nut allergy – British Society for Allergy and Clinical Immunology (free)

Editorial: Nut allergy guideline (free)

Commentary: First ever single guidance published for investigating and managing nut allergy – EurekAlert (free)

See also related guidelines (U.S.) and commentaries recommending early introduction of peanuts to prevent allergies in our January 6 issue, see #1 and #2.

 

7 – Data fabrication and other reasons for non-random sampling in 5087 randomised, controlled trials in anaesthetic and general medical journals – Anaesthesia (free)

Commentaries: Dozens of recent clinical trials may contain wrong or falsified data, claims study – The Guardian (free) AND Two in 100 clinical trials in eight major journals likely contain inaccurate data: Study – Retraction Watch (free)

 

8 – Inflammatory bowel disease: Five things physicians and patients should question – Choosing Wisely Canada (free)

 

9 – Association Between Cirrhosis and Stroke in a Nationally Representative Cohort – JAMA Neurology (free)

Commentary: Cirrhosis Tied to Stroke Risk- Physician’s First Watch (free)

Patients with cirrhosis seem to have a higher risk of stroke, particularly hemorrhagic stroke.

 

10 – Current Tobacco Smoking and Desire to Quit Smoking Among Students Aged 13–15 Years — Global Youth Tobacco Survey, 61 Countries, 2012–2015 – MMWR: Centers for Disease Control and Prevention (free)

Commentaries: What’s The Rate Of Smoking In The 13- To 15-Year-Old Crowd? – NPR Goats and Soda (free)

 

Mon, June 5 – 10 Medical Stories of The Day!

5Jun
2017

 

1 – #ASCO2017 – Overall Survival Results of a Trial Assessing Patient-Reported Outcomes for Symptom Monitoring During Routine Cancer Treatment – JAMA (free)

Commentaries: Quickly reporting cancer complications may boost survival – STAT News (free) AND If This Were a Drug, the Price Would Be $100,000 – Medscape (free registration required) AND How a simple tech tool can help cancer patients live longer – The Washington Post (free)

“For surveillance of cancer, digital tracking of patient-generated data improves survival”. “The cost of digital tracking is very low and > 5 months median survival improvement is more than cancer drugs that cost > $100,000” (RT @EricTopol see Tweets and Answers)

 

2 – #ASCO2017 – Abiraterone for Prostate Cancer

Abiraterone plus Prednisone in Metastatic, Castration-Sensitive Prostate Cancer – New England Journal of Medicine (free) AND Abiraterone for Prostate Cancer Not Previously Treated with Hormone Therapy – New England Journal of Medicine (free)

ASCO News Releases: Abiraterone Delays Metastatic Prostate Cancer Growth by 18 Months, Extends Survival (free) Abiraterone Slows Advanced Prostate Cancer, Helps Patients Live Longer (free)

 

3 – Perspectives: Changing the narratives for patient safety – World Health Organization (free)

“No simple solutions to patient safety: why we have to change the narratives” (RT @MaryDixonWoods See Tweet)

 

4 – Engaging Patients in Patient Safety – a Canadian Guide (free) (RT @pash22)

News release: How to Effectively Engage Patients in Patient Safety: New Guide available (free)

 

5 – ACP Decries Withdrawal from Climate Agreement – American College of Physicians (free)

See also: How scientists reacted to the US leaving the Paris climate agreement – Nature News (free) Leaving the Paris Climate Accord Could Lead to a Public Health Disaster – Scientific American (free)

Related guideline: Climate Change and Health: A Position Paper of the American College of Physicians (free)

See more on Climate Change and Health in our April 21 issue, see #6, #7, #8 and #9.

 

6 – Introducing a One-Page Adult Preventive Health Care Schedule: USPSTF Recommendations at a Glance – American Family Physician (free PDF)

“The popular one-page preventive health care schedule is now available with the latest USPSTF recs from 2017” (RT @AFPJournal see Tweet)

 

7 – Estimates of global, regional, and national morbidity, mortality, and aetiologies of diarrhoeal diseases: a systematic analysis for the Global Burden of Disease Study 2015 – The Lancet Infectious Diseases (free)

Invited commentary: Diarrhoeal disease trends in the GBD 2015 study: optimism tempered by skepticism (free)

Other commentaries: Despite substantial global reduction in diarrhea deaths, half a million children still die from diseases each year – Institute for Health Metrics and Evaluation (IHME) (free) AND Global diarrhoea deaths down by a third – BBC News (free)

“Deaths due to diarrhoea in children under 5 down 34% 2005-15, but still 4th leading cause of death” (RT @TheLancetInfDis see Tweet)

Global diarrhoea deaths in children down by a third, but still fourth biggest killer in under fives, >500,000 a year” (RT @anetrid see Tweet)

 

8 – Spondyloarthritis in over 16s: diagnosis and management – NICE Updated Guideline (free)

See also: 2016 update of the ASAS-EULAR management recommendations for axial spondyloarthritis (free)

 

9 – Italy has introduced mandatory vaccinations – other countries should follow its lead – The Conversation (free)

See more on mandatory vaccination in our May 29 issue, see #6

 

10 – Carotid Artery Stenting Versus Endarterectomy for Stroke Prevention: A Meta-Analysis of Clinical Trials – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: CAS vs. CEA for Stroke Prevention – American College of Cardiology, Latest in Cardiology (free)

“CAS and CEA were associated with similar rates of a composite of periprocedural death, stroke, MI, or nonperiprocedural ipsilateral stroke. The risk of long-term overall stroke was significantly higher with CAS, and was mostly attributed to periprocedural minor stroke”.

 

Tue, June 6 – 10 Medical Stories of The Day!

6Jun
2017

 

1 – The impact of the environment on children’s health – New WHO Reports

News release: The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free)

Report 1: Don’t pollute my future! The impact of the environment on children’s health – World Health Organization (free)

Report 2: Inheriting a sustainable world: Atlas on children’s health and the environment – World Health Organization (free)

Related links: WHO’s work on environmental health (free) AND 10 facts on children’s environmental health (free)

 

2 – #ASCO2017 – CT-P6 compared with reference trastuzumab for HER2-positive breast cancer: a randomised, double-blind, active-controlled, phase 3 equivalence trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Biosimilar May Be As Effective as Trastuzumab for Early Breast Cancer – Physician’s First Watch (free)

 

3 – #ASCO2017 – Small studies get big headlines at ASCO 2017 – HealthNewsReview (free)

“Claim – Biggest breakthrough in a decade”. “Reality – The trial included only 15 women; no survival outcomes measured” (RT @HealthNewsRevu see Tweet)

 

4 – Simplified diagnostic management of suspected pulmonary embolism (the YEARS study): a prospective, multicentre, cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Simplified Diagnosis of Acute PE: The YEARS Study – American College of Cardiology, Latest in Cardiology (free) AND A Simple, Safe Approach to Decrease Use of CT for Pulmonary Embolism – Journal Watch (free)

 

5 – Growth and Rupture Risk of Small Unruptured Intracranial Aneurysms: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Growth, rupture risk appear low for small intracranial aneurysms, review indicates – ACP Internist Weekly (free) AND How Frequently Do Small Brain Aneurysms Rupture? – MedPage Today (free registration required)

“The annualized rupture rate was 0% for aneurysms 3 mm or smaller, below 0.5% for aneurysms 5 mm or smaller, and below 1% for aneurysms 7 mm or smaller”

 

6 – Health officials set to release a list of drugs everyone on Earth should be able to access – STAT News (free)

“The World Health Organization is making a list of drugs that everyone on Earth should have access to” (RT @statnews see Tweet)

 

7 – Small Steps Can Save Millions of Lives – Bloomberg (free) (RT @ghn_news see Tweet)

“More people now die from noncommunicable diseases than from causes like malaria and polio. Policy makers need to catch up”.

 

8 – Data Sharing Statements for Clinical Trials — A Requirement of the International Committee of Medical Journal Editors (free)

 

9 – Assessing the Efficacy of First-Aid Measures in Physalia sp. Envenomation, Using Solution- and Blood Agarose-Based Models – Toxins (free)

Commentary: What is the best antidote for a jellyfish sting? (Clue: it’s not urine) – The Guardian (free)

Vinegar seems to be the best treatment.

 

10 – Prenatal antidepressant use and risk of attention-deficit/hyperactivity disorder in offspring: population based cohort study – The BMJ (free)

Editoral: The safety of antidepressants in pregnancy (free)

Commentary: Kids’ ADHD Risk May Be Linked to Mother’s Underlying Mental Health, Not Prenatal Antidepressant Use – Physician’s First Watch (free)

 

Fri, June 2 – 10 Medical Stories of The Day!

2Jun
2017

 

1 – EASL Clinical Practice Guidelines: The diagnosis and management of patients with primary biliary cholangitis (free)

Commentary: EASL releases updated guidelines for managing hepatitis B virus infection – Clinical Advisor (free registration required)

 

2 – Trial of Minocycline in a Clinically Isolated Syndrome of Multiple Sclerosis – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Minocycline to Delay the Onset of MS

Commentaries: Acne antibiotic delays development of multiple sclerosis in small trial – Reuters Health (free)

 

3 – Sofosbuvir, Velpatasvir, and Voxilaprevir for Previously Treated HCV Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: When DAA Treatment for Hepatitis C Fails, 3-Drug Regimen “Highly Effective” – Physician’s First Watch (free)

 

4 – Health Policy Trials: The Changing Face of Clinical Trials – New England Journal of Medicine (free)

 

5 – Prophylactic Acid-Suppressive Therapy in Hospitalized Adults: Indications, Benefits, and Infectious Complications – Critical Care Nurse (free)

Source: Restraint Urged Before Prescribing Acid-Suppressive Therapy in Hospitalized Patients – American Association of Critical-Care Nurses, via Newswise (free)

 

6 – Review: Chronic constipation: Update on management – Cleveland Clinic Journal of Medicine (free)

 

7 – Research transparency: 5 questions about open science answered – The Conversation (free)

 

8 – Viewpoint: No Shortcuts on the Long Road to Evidence-Based Genomic Medicine – JAMA (free)

“The need for evidence in genomic medicine is more important than ever” (RT @JAMA_current see Tweet)

 

9 – Editorial: Acting on Social Determinants of Health: A Primer for Family Physicians – American Family Physician (free) (RT @kennylinafp)

 

10 – Transient ischaemic attacks may have greater long-term impact than previously thought – NIHR Signal (free)

Original article: Ongoing impairments following transient ischaemic attack: retrospective cohort study – European Journal of Neurology (free)

 

Thu, June 1 – 10 Medical Stories of The Day!

1Jun
2017

 

1 – Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis – JAMA Cardiology (free) (RT @GreenlandRohan see Tweet)

Commentaries: Reducing blood pressure below recommended targets significantly reduces CVD, mortality risk – Clinical Advisor (free registration required) And New Review Supports Aggressive BP Targets – MedPage Today (free registration required)

Ideal blood pressure targets are controversial and recommendations vary across hypertension guidelines. This new meta-analysis suggests the risk of cardiovascular disease would be lowest with a systolic blood pressure between 120-124 mmHg.

 

2 – The UK Injection and Infusion Technique Recommendations 4th Edition – Forum for Injection Technique (FIT) (free PDF)

Commentary: New Guidance Focuses on Best Injection Practices for Diabetes – Medscape (free registration required)

Related guideline: New Insulin Delivery Recommendations – Mayo Clinic Proceedings (free)

 

3 – Review: Improving the Management of COPD in Women – Chest (free)

 

4 – World No Tobacco Day 2017 – Cochrane Evidence resources to support stop smoking efforts (free)

See also our coverage of World No Tobacco Day in our May 31 issue, see #1.

 

5 – Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free)

“Students used to take drugs to get high. Now they take them to get higher grades” (RT @ConversationUK see Tweet)

 

6 – Powerful New Ebola Vaccine Heads To Congo To Help Stop Outbreak – NPR Goats and Soda (free)

See also: DRC approves use of Ebola vaccine – CIDRAP (free) AND Ebola vaccine approved for use in ongoing outbreak – Nature News (free)

 

7 – State of the art review: Diagnosis and management of inflammatory bowel disease in children – The BMJ (free until 15 June)

 

8 – Cancer drugs are getting better and dearer – The Economist (a few articles per month are free) (RT @pash22 see Tweet)

See more articles and commentaries about “financial toxicity” of cancer treatments in our April 27 issue, see #8.

 

9 – A blood test threshold for diagnosing heart failure in general practice is reviewed – NIHR Signal (free)

Original article: Primary care REFerral for EchocaRdiogram (REFER) in heart failure: a diagnostic accuracy study (free)

“Most accurate diagnosis for heart failure in general practice came from using NTproBNP level at a low cut-off of ≥125 pg/ml” (RT @NIHR_DC see Tweet)

 

10 – Maternal and Fetal Outcomes of Anticoagulation in Pregnant Women With Mechanical Heart Valves – Journal of The American College of Cardiology (free)

Commentaries: Warfarin OK in Expectant Moms with Mechanical Heart Valve – MedPage Today (free registration required) AND Anticoagulation in Pregnant Women With Mechanical Valves – American College of Cardiology, Latest in Cardiology (free) (RT @keaglemd see Tweet)

In this meta-analysis, warfarin was associated with lower risk of adverse maternal outcomes, whereas LMWH was associated with lower risk of adverse fetal outcomes.

 

Wed, May 31 – 10 Medical Stories of The Day!

31May
2017

 

1 – World No Tobacco Day, 31 May 2017: Beating tobacco for health, prosperity, the environment and national development – World Health Organization (free)

Press release: World No Tobacco Day 2017: Beating tobacco for health, prosperity, the environment and national development (free)

See more on the Beating Tobacco Campaign in our May 29th issue, see #1.

 

2 – The British Society for Rheumatology Guideline for the Management of Gout – Rheumatology (free)

Source: BSR guideline: Urate-lowering drugs should be offered early in gout – Healio Rheumatology (free)

 

3 – Triple Therapy Versus Biologic Therapy for Active Rheumatoid Arthritis: A Cost-Effectiveness Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: In Rheumatoid Arthritis, Adding a Biologic Agent Before Trying Triple Therapy Likely Not Cost-Effective – Physician’s First Watch (free) AND Biologics before triple therapy not cost effective for rheumatoid arthritis – MedicalXpress (free) Triple Therapy More Cost-Effective Than MTX + Biologic in RA – Medscape (free registration required)

 

4 – Treatment of Osteoarthritis of the Knee: An Update Review – Agency for Healthcare Research and Quality (US) (Key messages and abstract – free)

See also: Executive Summary (free PDF) AND Full Report (free PDF)

Source: EvidenceAlerts

 

5 – Recommendations for the Use of Mechanical Circulatory Support: Ambulatory and Community Patient Care: A Scientific Statement From the American Heart Association (free PDF)

See also: News release (free) AND Top Ten Things to Know (free PDF)

Related: Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support: A Scientific Statement From the American Heart Association (free PDF) AND CPR in Patients With Mechanical Circulatory Support – American College of Cardiology, Latest in Cardiology (free)

 

6 – Clinical Policy: Critical Issues in the Evaluation and Management of Adult Patients Presenting to the Emergency Department With Acute Carbon Monoxide Poisoning – American College of Emergency Physicians (free)

Source: First10EM – Articles of the month, May 2017 (free)

 

7 – Handshake-Free Zones Target Spread Of Germs In The Hospital – NPR (free)

 

8 – Healthcare Providers Shouldn’t Come to Work While Sick, but They Do — Here’s Why – HIV and ID Observations, Journal Watch Blog (free)

 

9 – Richard Lehman’s weekly review of medical journals – The BMJ Blogs (free)

 

10 – Draft Recommendation Statement: Adolescent Idiopathic Scoliosis: Screening – U.S. Preventive Services Task Force (free)

Commentary: USPSTF: Not Enough Evidence to Recommend Routine Scoliosis Screening – Physician’s First Watch (free)

 

Tue, May 30 – 10 Medical Stories of The Day!

30May
2017

 

1 – B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)

Commentary: Some heart attack patients may not benefit from beta blockers – University of Leads, via Science Daily (free)

Large cohort suggests there may be no benefit in continuing B-Blockers in patients who do not develop heart failure or ventricular dysfunction after myocardial infarction.

 

2 – A New Renaissance in Pericardial Diseases – Progress in Cardiovascular Diseases (special issue with series of review articles on the management of pericardial disease).

Source: Hospital Medicine Virtual Journal Club

1 – Introduction: A New Renaissance in Pericardial Diseases (free)

2 – Structure and Anatomy of the Human Pericardium (free)

3 – Pathophysiology of the Pericardium (free)

4 – Acute Pericarditis (free)

5 – Recurrent Pericarditis (free)

6 – Constrictive Pericarditis: A Practical Clinical Approach (free)

7 – Pericardial Effusions: Causes, Diagnosis, and Management (free)

8 – Pericardial Masses, Cysts and Diverticula: A Comprehensive Review Using Multimodality Imaging (free)

9 – Congenital Absence of the Pericardium (free)

10 – Surgical Management of Pericardial Diseases (free)

 

3 – Sat-fat bait and switch – ACP Internist (free)

Related: Backlash after report claims saturated fats do not increase heart risk – The Guardian (free)

Interesting and balanced point of view arguing against recent articles suggesting saturated fats are not that bad (April 27th issue, see #3).

 

4 – Review: Current guidelines on prevention with a focus on dyslipidemias – Cardiovascular Diagnosis & Therapy (free)

Review comparing current recommendations for the treatment of dyslipidemia.

 

5 – Science Needs a Solution for the Temptation of Positive Results – The New York Times (10 articles per month are free)

 

6 – Diagnosis creep: the new problem in medicine – MJA Insight (free)

Related: How to rein in the widening disease definitions that label more healthy people as sick – The Conversation (free)

 

7 – Updated tutorial: What is a Systematic Review? – PubMed Health (free) (RT @hildabast)

 

8 – Report: From Panic and Neglect to Investing in Health Security: Financing Pandemic Preparedness at a National Level – World Bank (free PDF)

Press release: After Ebola and Zika, Most Countries Still Not Prepared for a Pandemic (free)

Commentary: World Bank says most nations not ready for pandemic – CIDRAP (free)

 

9 – The tiny pill which gave birth to an economic revolution – BBC News (free)

A great read—and a powerful reminder that contraceptives are one of the best tools we have to drive economic growth” (RT @melindagates see Tweet).

 

10 – Comparison of general obesity and measures of body fat distribution in older adults in relation to cancer risk: meta-analysis of individual participant data of seven prospective cohorts in Europe – British Journal of Cancer (free)

Commentaries: Why your waist measurement can predict cancer risk – The Guardian (free) AND Large Waist Raises Cancer Risk – Medscape (free registration required)

 

Mon, May 29 – 10 Medical Stories of The Day!

29May
2017

 

1 – Preparing for the next WHO Campaign: World No Tobacco Day, 31 May 2017 – World Health Organization (free infographics, posters, banners, publications and other resources for the upcoming campaign)

See also: “Tobacco Endgame” policies in our May 12th issue, see #3.

See also: Smoking prevalence and attributable disease burden in 195 countries and territories in our April 7th issue, see #1.

“Wednesday 31 May is World No Tobacco Day. Tweet using #NoTobacco “Protect health, reduce poverty, promote development” (RT @gmacscotland see Tweet)

 

2 – Type 2 diabetes in adults: management – NICE Guideline (free)

See also: Algorithm for blood glucose lowering therapy in adults with type 2 diabetes (free PDF)

Source: UK NICE Elevates SGLT2 Inhibitors in Diabetes Guidance – Medscape (free registration required)

 

3 – Viewpoint: Direct-to-Consumer Medical Testing in the Era of Value-Based Care – JAMA (free)

See also a recent discussion on direct-to-consumer genetic testing in our April 10th issue, see #5

Others disagree: “Dissing every consumer medical test as “low value”. Sorry, that’s not true. It’s called paternalism” (RT @EricTopol see Tweet)

 

4 – The Weight Loss Trap: Why Your Diet Isn’t Working – Time (cover story) (free)

“The challenges of weight loss and obesity – really well addressed” (RT @EricTopol see Tweet)

 

5 – Exercise and other non-pharmaceutical interventions for cancer-related fatigue in patients during or after cancer treatment: a systematic review incorporating an indirect-comparisons meta-analysis – British Journal of Sports Medicine (free)

Commentary: Several non-drug options help with fatigue during, after cancer treatment – Reuters Health News (free)

 

6 –  Countries like German and Italy are adopting mandatory vaccination policies

Germany vaccination: Fines plan as measles cases rise – BBC Health News (free) AND German kindergartens must report parents for refusing vaccine advice under new law – Reuters Health News (free)

See also: Italy makes 12 vaccinations compulsory for children and related commentaries in our May 22nd issue, see #2.

 

7 – #ATS2017 – Antibiotic therapy for nearly one in four adults with pneumonia does not work – American Thoracic Society, via Science Daily (free) (RT @IDSAInfo see Tweet)

See also: Pneumonia Treatment Failure Rates High – Medscape (free registration required) AND Adults With Pneumonia Often Fail First Antibiotic – MedPage Today (free registration required)

 

8 – Clinical relevance of thrombocytosis in primary care: a prospective cohort study of cancer incidence using English electronic medical records and cancer registry data – British Journal of General Practice (link to abstract – $ for full-text)

Commentaries: Cautions and caveats help buoy Guardian story on using high platelet count for cancer detection – HealthNewsReview (free) High blood platelet count ‘as good a cancer predictor as a lump in the breast’ – The Guardian (free)

Thrombocytosis seems to be a risk marker of cancer in adults, but questions remain about the clinical usefulness of these findings.

 

9 – New Guideline Summaries – National Guideline Clearinghouse (US):

1 – Systemic therapy of incurable gastroenteropancreatic neuroendocrine tumours – Cancer Care Ontario (free) AND 2 – Guidelines for the management of severe traumatic brain injury, 4th edition – Brain Trauma Foundation (free) AND 3 – American Gastroenterological Association Institute guideline on the management of Crohn’s disease after surgical resection – National Guideline Clearinghouse (free) AND 4 – Management of adult pancreatic injuries: a practice management guideline from the Eastern Association for the Surgery of Trauma – National Guideline Clearinghouse (free)

 

10 – Cancer Pain – Updated PDQ Cancer Information Summary, National Cancer Institute (US) (free)

 

Fri, May 26 – 10 Medical Stories of The Day!

26May
2017

 

1 – Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use – Circulation (link to abstract – $ for full-text)

Commentaries: Anabolic Steroid Use Linked With Myocardial Dysfunction and Accelerated Atherosclerosis – TCTMD (free) AND Chronic anabolic steroid use may damage heart – American Heart Association News (free)

“The findings are a public health concern, given that as many as 1% of young men, not all of them athletes, may use these agents” (from TCTMD above).

 

2 – The Surgical Infection Society Revised Guidelines on the Management of Intra-Abdominal Infection – Surgical Infections (free)

Related: Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference – World Journal of Emergency Surgery (free)

 

3 – Thrombolysis may reduce complications of deep vein thrombosis – NIHR Signal (free)

Original article: Thrombolysis for acute deep vein thrombosis – Cochrane Library (Link to abstract – $ for full-text)

Thrombolysis reduced post-thrombotic syndrome, but lead to more bleeding complications than standard anticoagulation. “Individuals with clots in the pelvis and thigh, which carry higher risk of complications, may be likely to gain most benefit”.

 

4 – Induction of labour within 24 hours, if waters break at 37 weeks of pregnancy, can reduce womb infection – NIHR Signal (free)

Original article: Planned early birth versus expectant management (waiting) for prelabour rupture of membranes at term (37 weeks or more) – Cochrane Library (Link to abstract – $ for full-text)

“Inducing labour within 24hrs may halve risk of infection in the womb when waters break from 37 weeks” (RT @NIHR_DC see Tweet)

 

5 – Diagnostic accuracy of post-mortem CT with targeted coronary angiography versus autopsy for coroner-requested post-mortem investigations: a prospective, masked, comparison study – The Lancet (free)

Editorial: Targeted coronary post-mortem CT angiography, straight to the heart (free)

Commentary: Digital autopsies should be standard for probable natural deaths, says study – The Guardian (free)

 

6 – American Society of Clinical Oncology (ASCO) 2017 Annual Meeting

Can cashews keep colon cancer patients alive? Study says yes — but cautions abound – STAT News (free) AND Reducing Risk After Cancer: Healthy Lifestyle (and Tree Nuts) – Medscape (free registration required)

 

7 – Recent articles on payment models published in JAMA

The Next Generation of Episode-Based Payments – JAMA (free) AND Value-Based Payment Models for Community Health Centers: Time to (Cautiously) Take the Plunge? – JAMA (free) AND Business Model–Related Conflict of Interests in Medicine: Problems and Potential Solutions – JAMA (free)

 

8 – Idiopathic pulmonary fibrosis in adults: diagnosis and management – NICE Guideline (free)

 

9 – Eating disorders: recognition and treatment – NICE Guideline (free)

 

10 – The lap band for weight loss is a tale of medicine gone wrong – VOX (free)

See also a recent study showing high complication rates of laparoscopic gastric band surgeries in our May 23rd issue (see #7)

 

Wed, May 24 – 10 Medical Stories of The Day!

24May
2017

 

1 – World Health Assembly elects Dr Tedros Adhanom Ghebreyesus as new WHO Director-General – WHO Media Center (free)

Commentaries: World Health Organization gets first leader from Africa – Nature News (free) AND WHO elects first ever African director-general after tense vote – The Guardian (free) AND World Health Organization Elects a New Director General from Ethiopia – TIME (free)

 

2 – Electronic WHO Postpartum Family Planning Compendium – World Health Organization (free)

How to use it: Introducing the World Health Organization Postpartum Family Planning Compendium – International Journal of Gynaecology and Obstetrics (free)

This interactive website integrates essential guidance on postpartum family planning for clinicians, program managers, and policy makers.

 

3 – Review: Perioperative management of patients on direct oral anticoagulants – Thrombosis Journal (free)

 

4 – Guidelines for screening and management of late and long-term consequences of myeloma and its treatment – British Journal of Haematology (free)

Related: Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology (free)

 

5 – Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support: A Scientific Statement From the American Heart Association (free PDF)

See also: News release (free) AND Top Ten Things to Know (free PDF)

 

6 – Diet, Nutrition, Physical Activity and Breast Cancer – American Institute for Cancer Research (free PDF)

News release: Just one alcoholic drink a day increases breast cancer risk, exercise lowers risk – American Institute for Cancer Research, via EurekAlert (free)

Commentaries: Today’s alcohol and breast cancer headlines are wrong: Here’s how news reports could have done better – HealthNewsReview (free) AND ‘Half a glass of wine every day’ increases breast cancer risk – BBC Health News (free) AND Just One Drink a Day Raises Breast Cancer Risk – Medscape (free registration required)

 

7 – #ATS2017 – COPD National Action Plan – National Heart, Lung and Blood Institute (link to summary) PDF report available for download (free)

Source: ATS 2017: New COPD Action Plan Outlines Strategies for Improved Care – University of Michigan, via NewsWise (free)

 

8 – The Worst Fat in the Food Supply – The New York Times (10 articles per month are free)

See also a recent study and commentaries on the effects of trans-fat bans in our April 23rd issue (see #1)

Trans-fat bans seem to be reducing cardiovascular deaths.

 

9 – Richard Lehman’s weekly review of medical journals, 22 May 2017 – The BMJ Blogs (free)

 

10 – Association of Long-term Opioid Therapy With Functional Status, Adverse Outcomes, and Mortality Among Patients With Polyneuropathy – JAMA Neurology (free)

Editorial: Lack of Evidence for Benefit From Long-term Use of Opioid Analgesics for Patients With Neuropathy (free)

Commentaries: Long-Term Opioid Treatment Seems Only to Add Complications to Polyneuropathy – Physician’s First Watch (free) AND Long-Term Opioids May Not Help in Polyneuropathy – MedPage Today (free registration required)

“Patients had worse functional outcomes than controls; some became dependent” (from MedPage Today)

 

Thu, May 25 – 10 Medical Stories of The Day!

25May
2017

 

1 – Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study – BMJ (free)

Recommended: New QRISK-3 2017 Calculator (free)

QRISK-3 risk prediction model was developed with data from 7.89 million patients in the derivation cohort and 2.67 million patients in the validation cohort. QRISK-3 includes more factors than QRISK2 to help enable doctors to identify those at most risk of heart disease and stroke. New risk factors include: 1) Chronic kidney disease, which now includes stage 3 CKD; 2) Migraine; 3) Use of corticosteroids; 4) Systemic lupus erythematosus (SLE); 5) Use of atypical antipsychotics; 6) Severe mental illness; 7) Erectile dysfunction; 8) and Systolic blood pressure variability.

 

2 – Stroke in Childhood: Clinical guideline for diagnosis, management and rehabilitation (2017) – Royal College of Paediatrics and Child Health (free PDF) (RT @bmj_latest see Tweet)

News release: New guidelines launched to help healthcare professionals and parents spot the signs of stroke in children (free)

Other resources: Stroke in Childhood: Clinical guideline for diagnosis, management and rehabilitation (2017) (free)

 

3 – Effect of Cephalexin Plus Trimethoprim-Sulfamethoxazole vs Cephalexin Alone on Clinical Cure of Uncomplicated Cellulitis: A Randomized Clinical Trial – JAMA (Link to abstract – $ for full-text)

Commentaries: Adding Anti-MRSA to Cephalexin No Better for Simple Cellulitis – Medscape (free registration required) AND Adding TMP/SMX to Cephalexin May Not Boost Cure Rate in Uncomplicated Cellulitis – Physician’s First Watch (free)

 

4 – Oil-Based or Water-Based Contrast for Hysterosalpingography in Infertile Women – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Study confirms ‘flushing’ blocked fallopian tubes can improve fertility and reduce need for IVF – The Conversation (free) AND Can poppyseed oil help infertile couples conceive? – STAT News (free)

 

5 – Effect of a Modified Hospital Elder Life Program on Delirium and Length of Hospital Stay in Patients Undergoing Abdominal Surgery: A Cluster Randomized Clinical Trial – JAMA Surgery (free) (RT @PreetiNMalani see Tweet)

Commentary: Anti-delirium strategy reduces after-surgery confusion in elderly – Reuters Health (free)

Multicomponent nonpharmacologic interventions, including orienting communications, oral and nutritional assistance, and early mobilization reduced postoperative delirium by 56% and length of stay by 2 days.

 

6 – Very strict blood sugar control in critically ill children provides no benefit – NIHR Signal (free)

Original article (link to abstract – $ for full-text): Tight Glycemic Control in Critically Ill Children – New England Journal of Medicine (free)

 

7 – Human papillomavirus vaccines: WHO position paper, May 2017 – World Health Organization Weekly epidemiological record (free PDF)

“WHO update on HPV vaccine. Short summary – it’s very safe, very effective, widespread implementation recommended” (RT @michaelghead see Tweet)

 

8 – Factors Associated with Pediatric Mortality from Motor Vehicle Crashes in the United States: A State-Based Analysis – The Journal of Pediatrics (free PDF)

Commentaries: 43 Percent Of Children Who Died From Car Crashes Were Improperly Restrained – NPR Health News (free)

 

9 – Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (link to abstract – $ for full-text) (RT @Gas_Craic see Tweet)

Compared with culprit-only intervention, the complete revascularisation strategy may be superior due to lower proportions of long-term cardiovascular mortality, long-term revascularisation, and long-term non-fatal myocardial infarction, but these findings are based on evidence of very low quality”

 

10 – Angioedema in the emergency department: a practical guide to differential diagnosis and management – International Journal of Emergency Medicine (free) (RT @Gas_Craic see Tweet)

 

Tue, May 23 – 10 Medical Stories of The Day!

23May
2017

 

1- Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)

Editorial: Risks of Statin Therapy in Older Adults (free)

Commentaries: Older adults may not benefit from taking statins to prevent heart disease – Medical News Today (free) AND Pravastatin Doesn’t Improve Clinical Outcomes in Seniors – Physician’s First Watch (free)

Patients > 65 years with moderate hyperlipidemia and hypertension had no benefit from pravastatin for primary prevention. “A nonsignificant direction toward increased all-cause mortality with pravastatin was observed among adults 75 years and older” (HR 1.34; 95% CI, 0.98-1.84; P = .07).

 

2 – Fruit Juice in Infants, Children, and Adolescents: Current Recommendations – American Academy of Pediatrics (free)

Commentaries: Pediatricians Advise No Fruit Juice Until Kids Are 1 – NPR Health News (free) AND Pediatricians Say No Fruit Juice in Child’s First Year – New York Times (10 articles per month are free)

 

3 – #ATS2017 – Effect of Home Noninvasive Ventilation With Oxygen Therapy vs Oxygen Therapy Alone on Hospital Readmission or Death After an Acute COPD Exacerbation: A Randomized Clinical Trial – JAMA (free)

Editorial: Home Noninvasive Ventilation to Reduce Readmissions for Chronic Obstructive Pulmonary Disease (free)

Commentary: Addition of Home Noninvasive Ventilation Tied to Fewer Readmissions After COPD Exacerbation – Physician’s First Watch (free)

 

4 – #ATS2017 – Directly Observed Therapy for Multidrug-Resistant TB Decreases Mortality – ATS 2017 Conference (free summary)

Directly Observed Therapy (DOT) for multidrug-resistant tuberculosis (MDR TB) was associated with a 77 percent decrease in mortality in observational study.

 

5 – Cancer screening in the United States, 2017: A review of current American Cancer Society guidelines and current issues in cancer screening – CA: A Cancer Journal for Clinicians (free)

 

6 – Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults – United European Gastroenterology Journals (free)

 

7 – Reoperation and Medicare Expenditures After Laparoscopic Gastric Band Surgery – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Following gastric band surgery, device-related reoperation common, costly – Science Daily (free) AND Safety, Effectiveness of Gastric Banding Called Into Question – Medscape (free registration required) AND 1 In 5 Gastric Band Surgeries Require Corrective Operations – American Council on Science and Health (free)

 

8 – American Urological Assn. Adds 5 More Unnecessary Practices to Choosing Wisely – Physician’s First Watch (free)

See also: Complete American Urological Association list with 15 Things Physicians and Patients Should Question – Choosing Wisely (free)

 

9 – Effects of the Informed Health Choices primary school intervention on the ability of children in Uganda to assess the reliability of claims about treatment effects: a cluster-randomised controlled trial – The Lancet (free registration required)

Commentaries: Belief in health bullshit is a global problem; a big study points to solutions – HealthNewsReview (free) AND This researcher may have discovered the antidote to health bullshit – VOX (free)

 

10 – Metformin, Lifestyle Intervention, and Cognition in the Diabetes Prevention Program Outcomes Study – Diabetes Care (link to abstract – $ for full-text)

Commentary: Long-term Metformin Use ‘Has No Cognitive Impact’ – Medscape (free registration required)

Contradicting previous studies suggesting a link between metformin use and cognitive impairment, possibly related to an impaired absorption of B12, this study has shown no such association.

 

Mon, May 22 – 10 Medical Stories of The Day!

22May
2017

 

1 – Time to Treatment and Mortality during Mandated Emergency Care for Sepsis – New England Journal of Medicine (free)

Commentary: Doctors have resisted guidelines to treat sepsis. New study suggests those guidelines save lives – STAT News (free)

“For every hour you delay antibiotics in sepsis, mortality goes up” (RT @CMichaelGibson see Tweet)

“Trauma: Golden Hour

Cardiology: Time is muscle

Neurology: Time is brain

Sepsis: Early antibiotics to survive”

(interesting remark by @CMichaelGibson see Tweet)

 

2 – Italy makes 12 vaccinations compulsory for children – BBC Health News (free) AND Italy passes law obliging parents to vaccinate children – Reuters Health (free)

Related: Embrace the facts about vaccines, not the myths – World Health Organization (free) AND World Immunisation Week: The Rise of Anti-Vaccine Movement and What it Means for Public Health – Independent (free) AND The riskiest vaccine? The one that is not given – Science (free)

“If children are not vaccinated by the age of six, the school starting age, their parents will be fined” (RT @anetrid see Tweet)

 

3 – Science Has Begun Taking Gluten Seriously – The Atlantic (free)

Original article: Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study – The BMJ (free)

“New research from Harvard and Columbia says gluten does not cause heart disease. Why is that even a question?”

 

4 – The effect of replacing saturated fat with mostly n-6 polyunsaturated fat on coronary heart disease: a meta-analysis of randomised controlled trials – Nutrition Journal (free)

There has been a lot of controversy going on over the benefits and harms of saturated fats (April 27th issue, see #3) and it is difficult to interpret this new meta-analysis from randomized trials suggesting there may be no benefit from replacing saturated fats for unsaturated fats, since they contradict current guidelines and most epidemiological data from high-quality, long-term prospective cohort studies.

 

5 – Report: Healthier, fairer, safer: the global health journey 2007–2017 (free)

“New report on WHO’s role in Global Health by Sir Liam Donaldson” (RT @WHO see Tweet)

 

6 – Healthcare Access and Quality Index based on mortality from causes amenable to personal health care in 195 countries and territories, 1990–2015: a novel analysis from the Global Burden of Disease Study 2015 – The Lancet (free)

Commentaries: First-ever global study finds massive health care inequity – Institute for Health Metrics and Evaluatio (IHME) (free) AND Account for primary health care when indexing access and quality – The Lancet (free)

 

7 – Without action on antibiotics, medicine will return to the dark ages – The Guardian (free)

See more on “superbugs” in our February 28th issue (see #1), April 6th issue (see #9) and also in our Selection of news and education resources on Antibiotic Resistance

 

8 – Finally, Success Reducing Recurrent Stroke With PFO Closure – Medscape (free registration required)

Two randomized trials presented at the 3rd European Stroke Organization Conference (ESOC) 2017 showed that in carefully selected stroke patients in whom Patent Foramen Oval (PFO) was suspected to be a cause of their strokes, a reduction in recurrent stroke was observed with PFO closure.

 

9 – Report: #StatusOfMind Social media and young people’s mental health and wellbeing – Royal Society of Public Health (link to introduction – free PDF)

Commentaries: Instagram ‘worst for young mental health’ – BBC News (free) AND Instagram worst social media app for young people’s mental health – CNN news (free)

 

10 – Point of view: Is ‘Internet Addiction’ Real? – NPR Health News (free)

 

Thu, May 18 – 10 Medical Stories of The Day!

18May
2017

 

1 – Report: World Health Statistics 2017: Monitoring health for the SDGs – World Health Organization (free)

News release: Almost half of all deaths now have a recorded cause, WHO data show (free)

See also: World Health Statistics data visualizations dashboard – Monitoring health for the SDGs (free)

Commentaries: More Than Half of World’s Deaths Still Have No Recorded Cause – Scientific American (free) Reporting of Global Vital Death Statistics Improving: WHO – Medscape (free registration required)

 

2 – Global, Regional, and National Burden of Cardiovascular Diseases for 10 Causes, 1990 to 2015 – Journal of The American College of Cardiology (free)

Commentaries: Cardiovascular disease causes one-third of deaths worldwide – Institute for Health Metrics and Evaluation (IHME) (free) AND CVD Causes One-Third of Deaths Worldwide: Study Examines Global Burden of CVD From 1990 to 2015 – American College of Cardiology, Latest in Cardiology (free)

“New Study: Cardiovascular disease causes one-third of deaths worldwide” (RT @IHME_UW see Tweet)

 

3 – Systematic Review: Antenatal corticosteroids for accelerating fetal lung maturation for women at risk of preterm birth – Cochrane Library (link to summary)

Source: A dose of corticosteroids benefit most women anticipating a preterm delivery – NIHR Dissemination Centre Discover Portal (free)

 

4 – Physician age and outcomes in elderly patients in hospital in the US: observational study – The BMJ (free)

Editorial: Physician age and patient outcomes (free)

Commentaries: Patients fare worse with older doctors, study finds – STAT News (free) AND Mortality Higher Among Inpatients Treated by Older Physicians – Medscape (free registration required) AND Study links physician age to patient mortality risk – EurekAlert (free)

 

5 – FDA Drug Safety Communication: FDA confirms increased risk of leg and foot amputations with the diabetes medicine canagliflozin (Invokana, Invokamet, Invokamet XR) (free)

Commentaries: FDA warns of foot, leg amputations with J&J diabetes drug – Reuters Health News (free) (RT @davidludwigmd) AND FDA Adds Boxed Warning to Canagliflozin for Increased Amputation Risk – Physician’s First Watch (free)

See also our May 11th issue with commentaries on a recent study showing that nearly 1 In 3 recent FDA drug approvals are followed by major safety concerns in the following years, see #10.

 

6 – What the World Will Learn from Chile’s Bold Policy to Curb Obesity – Bloomberg Philantropies Blog (free)

“Chile’s advertising policies stop high sugar, salt, fat products marketing to kids using cartoon characters” (RT @OPCAustralia see Tweet)

 

7 – The science behind One Health: at the interface of humans, animals, and the environment – Annals of the New York Academy of Sciences (free) (RT @greg_folkers see Tweet)

Related: One Health – Centers for Disease Control and Prevention (CDC) Resources (free) AND Advancing One Health Policy and Implementation Through the Concept of One Medicine One Science – Global Advances in Health and Medicine (free) AND One Medicine One Science: a framework for exploring challenges at the intersection of animals, humans, and the environment – Annals of the New York Academy of Sciences (free)

 

8 – Richard Lehman reviews the latest research in the top medical journals – The BMJ Blogs (free)

 

9 – Caffeine overdose is extremely rare — but here’s how it can happen – VOX (free) (RT @juliaoftoronto see Tweet)

 

10 – Review: Nutrition and metabolism in burn patients – Burns & Trauma (free)

 

Fri, May 19 – 10 Medical Stories of The Day!

19May
2017

 

1 – Joint statement on public disclosure of results from clinical trials – World Health Organization (free)

News release: Major research funders and international NGOs to implement WHO standards on reporting clinical trial results (free)

Commentary: Industry leaders agree to implement UN agency’s standards on clinical trial reporting – United Nations News Centre (free)

“Funders of medical research & international NGOs to implement WHO standards on reporting clinical trial results”. “Today, on average 50% of Clinical Trials go unreported, according to several studies, often because the results are negative”. “Unreported trial results leave an incomplete & potentially misleading picture of the risks & benefits of vaccines, drugs and medical devices” (see Tweets)

 

2 – Health and Public Policy to Facilitate Effective Prevention and Treatment of Substance Use Disorders Involving Illicit and Prescription Drugs: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

News release: ACP issues recommendations to prevent and treat substance use disorders (free)

Commentary: Treat Addiction Like a Chronic Disease, ACP Recommends – AJMC (free)

 

3 – Viewpoint: Primary Care of Patients with Chronic Pain – JAMA (free)

“Opioids should be a therapy of last resort rather than the first choice as is often the case currently”.

 

4 – Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free)

Commentary: New Guideline Recommends Opioids Only as a Last Resort – Medscape (free registration required)

 

5 – The Best Intervention: Gavi CEO Seth Berkley’s Q&A, Part I – Global Health NOW (free)

“Perhaps just 10% of the world’s children receive all 11 vaccines recommended by the @WHO, says @GaviSeth, @Gavi CEO” (RT @ghn_news see Tweet)

 

6 – Tackling Ebola outbreak in remote Congo presents huge challenge: WHO – Reuters Health (free)

Related: As DRC Ebola cases grow, expert sees parallels to Guinea – CIDRAP (free) As Ebola outbreak grows, question of using vaccine becomes more urgent – Science (free) (RT @greg_folkers) AND Suspected Cases of Ebola Rise to 18 in Democratic Republic of Congo – The New York Times (10 articles per month are free)

 

7 – New Advice to Move More After a Concussion – The New York Times (10 articles per month are free)

Related: Consensus statement on concussion in sport—the 5th international conference on concussion in sport held in Berlin, October 2016 – British Journal of Sports Medicine (free) AND So, Tom Brady had a concussion. What does that mean? Your guide to the latest science – STAT News (free)

 

8 – Pressure ulcer prevention and treatment. Is ‘best practice’ evidence-based? – Cochrane Blogs: Evidence for Everyday Nursing (free) (RT @CochraneUK see Tweet)

Evidence for the treatment of pressure ulcers reviewed.

 

9 – Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Exercise and Dieting in Obese Older Adults (free)

Commentary: Aerobic Plus Resistance Exercise Best for Obese Older Adults – MedPage Today (free)

 

10 – Long-term oxygen therapy shows no benefit for moderate lung disease – NIHR Signal: Dissemination Centre Discover Portal (free)

Original article: A Randomized Trial of Long-Term Oxygen for COPD with Moderate Desaturation – New England Journal of Medicine (free)

Patients with stable COPD and moderate resting desaturation (Spo2, 89 to 93%) or moderate exercise-induced desaturation (during the 6-minute walk test, Spo2 ≥80% for ≥5 minutes and <90% for ≥10 seconds) don’t seem to benefit from supplemental oxygen therapy.

 

Wed, May 17 – 10 Medical Stories of The Day!

17May
2017

 

1 – Global accelerated action for the health of adolescents (AA-HA!): Guidance to support country implementation – World Health Organization (free)

News release: More than 1.2 million adolescents die every year, nearly all preventable – World Health Organization (free)

Commentaries: How Many Teenagers Die Each Day … And Why – NPR Goats and Soda (free) AND 1.2 million adolescents’ deaths mostly preventable, report says – CNN (free) AND Pregnancy problems are leading global killer of ​​females aged 15 to 19 – The Guardian (free) AND Road accidents biggest global killer of teenagers – BBC News (free)

See also recently released Lancet Series making a case for global investment in the capabilities of adolescents, see #2.

 

2 – Cough in Children – Chest Guidelines

Use of Management Pathways or Algorithms in Children With Chronic Cough: CHEST Guideline and Expert Panel Report (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis: CHEST Guideline and Expert Panel Report (free)

See also other recent CHEST guidelines on the management of cough in Adults: Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND / Cough in the athlete (free) AND / Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND / Treatment of Unexplained Chronic Cough (free)

 

3 – WHO prepares experimental Ebola vaccine for possible first use in Democratic Republic of Congo – STAT News (free)

Related: WHO preparing authorization, logistics for Ebola vaccination in Congo if needed – Reuters Health (free)

 

4 – Viewpoint: How to rein in the widening disease definitions that label more healthy people as sick – The Conversation (free)

 

5 – Draft Recommendation Statement: Menopausal Hormone Therapy: Primary Prevention of Chronic Conditions – U.S. Preventive Services Task Force (free)

Source: USPSTF Recommendation Against HRT for Chronic Conditions Stands – Medscape (free registration required)

The USPSTF recommends against the use of combined estrogen and progestin for the prevention of chronic conditions in postmenopausal women”.

 

6 – Effect of Intra-articular Triamcinolone vs Saline on Knee Cartilage Volume and Pain in Patients With Knee Osteoarthritis: A Randomized Clinical Trial – JAMA (free)

Author interview video: Comparison of Intra-articular Triamcinolone vs Saline for Knee Osteoarthritis (free)

JAMA report video: Comparison of Intra-articular Triamcinolone vs Saline for Knee Osteoarthritis (free)

Source: Study: Intra-articular triamcinolone not effective for symptomatic knee osteoarthritis – Healio Rheumatology (free)

 

7 – Therapeutic Approach to Adult Fibrotic Lung Diseases – Chest (free)

Source: Hospital Medicine Virtual Journal Club

 

8 – Early Versus Delayed Feeding in Patients With Acute Pancreatitis: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Faster Feeding May Mean Faster Recovery in Pancreatitis – NewsWise (free) AND Early Feeding May Benefit Patients With Mild Pancreatitis – Medscape (free registration required).

For patients with mild to moderate pancreatitis, early feeding appears to be safe and may reduce length of hospital stay.

 

9 – Review: Renal dysfunction in cirrhosis: acute kidney injury and the hepatorenal syndrome – Gastroenterology Report (free)

Source: Critical Care Reviews Newsletter

 

10 – Review: Portal vein thrombosis in patients with cirrhosis – Gastroenterology Report (free)

Source: Critical Care Reviews Newsletter

 

Tue, May 16 – 10 Medical Stories of The Day!

16May
2017

 

1 – Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs: A Bayesian meta-analysis of survival data – Diabetes, Obesity and Metabolism (free)

Source: Review: Sulfonylureas are associated with overall mortality and CV events vs other antihyperglycemics – ACP Diabetes Monthly (free)

 

2 – Prevalence of Elevated Cardiovascular Risks in Young Adults: A Cross-sectional Analysis of National Health and Nutrition Examination Surveys – Annals of Internal Medicine (link to abstract – $ for full-text)

Source: Study Assesses ASCVD Risk in Non-Diabetic Adults – American College of Cardiology, Latest in Cardiology (free)

In the absence of diabetes, smoking or hypertension, most adult men younger than 40 years and adult women younger than 50 years are at low risk of cardiovascular disease (defined as < 5% in 10 years, usually not eligible for statin therapy) and may not benefit from cholesterol screening.

 

3 – BTS guideline for oxygen use in adults in healthcare and emergency settings – British Thoracic Society (free PDF via Critical Care Reviews)

 

4 – Updated: Will vaccine help curb new Ebola outbreak in the DRC? – Science (free)

“A comprehensive update on Ebola outbreak in DRC. Still unclear whether vaccine requested” (RT @sciencecohen see Tweet)

 

5 – Editorial: Drowning: a silent killer – The Lancet (free)

See also the World Health Organization report on Preventing Drowning in our May 3rd issue, see #2

 

6 – Report: Global Health and the Future Role of the United States – The National Academies of Sciences, Engineering, and Medicine (free)

Source: New report recommends priority actions to achieve global health security – EurekAlert (free)

 

7 – Switching from originator infliximab to biosimilar CT-P13 compared with maintained treatment with originator infliximab (NOR-SWITCH): a 52-week, randomised, double-blind, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentary: Celltrion Healthcare: Lancet Publishes Full Data-Set from Influential NOR-SWITCH Study – Business Wire (free)

 

8 – Choosing Wisely? Measuring the Burden of Medications in Older Adults near the End of Life: Nationwide, Longitudinal Cohort Study – The American Journal of Medicine (free)

See related study on the use of Medications of Questionable Benefit at the End of Life in our April 10th issue, see #8 and Deprescribing guidelines for elderly in our May 8th issue, see #4.

Source: Patient often prescribed potentially futile drugs in their final months of life – Science Daily (free)

“Nearly half of older adults in Sweden take 10 or more medications in their last months of life” (from Science Daily)

 

9 – Review: Recent advances in the management of variceal bleeding – Gastroenterology Report (free)

Source: Critical Care Reviews Newsletter

 

10 – Review: Hepatic encephalopathy – Gastroenterology Report (free)

Source: Critical Care Reviews Newsletter

 

Thu, May 11 – 10 Medical Stories of The Day!

11May
2017

 

1 – Practice guideline summary: Reducing brain injury following cardiopulmonary resuscitation (link to abstract – free PDF available)

Sources: Guideline: Offer Cooling After Cardiac Arrest – MedPage Today (free) AND Body Cooling Recommended for Some Comatose Patients After Cardiac Arrest – Physician’s First Watch (free)

 

2 – Ten Principles of Good Prescribing – by J K Aronson, Centre for Evidence-Based Medicine (CEBM) (free)

 

3 – Estimating the future burden of multidrug-resistant and extensively drug-resistant tuberculosis in India, the Philippines, Russia, and South Africa: a mathematical modelling study – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Drug Resistant TB Is Predicted To Steadily Spread In 4 Countries – NPR Goats and Soda (free) AND The Deadliest Form Of Tuberculosis Is Snowballing In Countries That Are Already Hard Hit – Huffington Post (free) AND Researchers Predict Increase in Drug-resistant TB – VOA News (free) AND Drug-resistant tuberculosis strains gain foothold – Science (free)

See also our coverage of #WorldTBDay in our March 24th issue

 

4 – Survival of HIV-positive patients starting antiretroviral therapy between 1996 and 2013: a collaborative analysis of cohort studies – The Lancet HIV (free)

Invited commentary: Improved life expectancy of people living with HIV: who is left behind? (free)

Source: Treatment now gives some HIV patients a normal life expectancy, study finds – STAT News (free)

 

5 – Risk of acute myocardial infarction with NSAIDs in real world use: bayesian meta-analysis of individual patient data – The BMJ (free)

Commentaries: Meta-Analysis: Just a Week of NSAID Use Tied to Increased Heart Attack Risk – Journal Watch (free) AND Common painkillers linked to increased risk of heart attack, study says – CNN (free) All NSAIDs Linked to Increased MI Risk – Medscape (free registration required)

Another study suggesting NSAIDs may be associated with increased cardiovascular risk.

 

6 – Meta-Analysis of Drug-Eluting Stents Versus Coronary Artery Bypass Grafting in Unprotected Left Main Coronary Narrowing – Journal of The American College of Cardiology (link to abstract – $ for full-text) (source: EvidenceAlerts)

Related recent meta-analysis: Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials – Circulation: Cardiovascular Interventions (free) AND Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis – BMC Medicine (free)

PCI with drug-eluding stents seems to be a safe alternative to CABG in Unprotected Left Main Coronary Artery Stenosis, but it is associated with higher rates of repeat revascularization.

 

7 – How To Do A Really Good Job Washing Your Hands – NPR Health News (free)

See also World Health Organization and Centers for Disease Control and Prevention (CDC) “Clean Hands” campaigns in our May 5th issue, see #2.

 

8 – Clinically Localized Prostate Cancer: AUA/ASTRO/SUO Guideline (free)

Source: Urologic Groups Offer New Prostate Cancer Management Guideline – Physician’s First Watch (free)

 

9 – Antibiotic Prescribing for Nonbacterial Acute Upper Respiratory Infections in Elderly Persons – Annals of Internal Medicine (link to abstract – $ for full-text)

Source: Half of all seniors who went to doctor for common cold prescribed unnecessary antibiotics – Science Magazine (free)

 

10 – Review: Current Trends in the Management of Gastroesophageal Reflux Disease – Gut and Liver (free PDF)

 

Mon, May 15 – 10 Medical Stories of The Day!

15May
2017

 

1 – Guideline: Hip fracture: management – National Institute for Health and Care Excellence (NICE – UK) (free)

 

2 – Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)

See more on “Deprescribing” in our May 9th issue (see #7) and in our May 8th issue (see #4)

 

3 – Ebola virus disease: Democratic Republic of the Congo – World Health Organization (free)

Updated fact sheet: Ebola virus disease (free) (RT @greg_folkers)

See also: WHO confirms second Ebola case in Congo outbreak – Reuters Health (free) AND Ebola Outbreak Is Declared in Congo, With at Least 3 Dead – The New York Times (10 articles per month are free) AND Ebola: WHO declares outbreak in DR Congo – BBC News (free) AND Ebola: an outbreak has been confirmed in the DRC. Here’s what you need to know – VOX (free) AND The Confusion Over the New Ebola Outbreak – The Atlantic (free) (RT @juliaoftoronto)

 

4 – Cybercrime and healthcare

The hackers holding hospitals to ransom – The BMJ (free) AND NHS cyber-attack: GPs and hospitals hit by ransomware – BBC News (free) AND Disruption from cyber-attack to last for days, says NHS Digital – as it happened – The Guardian (free) AND Worldwide ransomware attack hits NHS hospitals – video – The Guardian (free) AND British Patients Reel as Hospitals Race to Revive Computer Systems – The New York Times (10 articles per month are free) AND Hackers Hit Dozens of Countries Exploiting Stolen N.S.A. Tool – New York Times (10 articles per month are free)

Many hospitals were affected around the world.

 

5 – Treatment Deintensification Is Uncommon in Adults With Type 2 Diabetes Mellitus: A Retrospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (link to abstract – $ for full-text)

Source: Treatment deintensification uncommon in type 2 diabetes – ACP Internist (free)

Editorial: Diabetes Mellitus Treatment Deintensification: When Well-Controlled Diabetes Mellitus Becomes Overcontrolled (free)

 

6 – Zika virus: Brazil says emergency is over – BBC (free) (RT @AthaliaChristie see Tweet)

Related: Brazil announces end to Zika public health emergency – The Guardian (free)

 

7 – Management of intra-abdominal infections: recommendations by the WSES 2016 consensus conference – World Journal of Emergency Surgery (free)

Source: Critical Care Reviews Newsletter

 

8 – 2016 AHA/ACC Guideline on the Management of Patients With Lower Extremity Peripheral Artery Disease: Executive Summary: A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines – Journal of the American College of Cardiology (free, and legal, PDF via Unpawall)

 

9 – Review: Infection in systemic lupus erythematosus, similarities, and differences with lupus flare – Korean Journal of Internal Medicine (free)

 

10 – Researchers have ditched the autism-vaccine theory. Here’s what they think actually causes it – VOX (free)

 

Fri, May 12 – 10 Medical Stories of The Day!

12May
2017

 

1 – Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline – The BMJ (free)

Commentaries: This orthopedic surgery is the world’s most common. But patients rarely benefit, a panel says – STAT News (free) AND Guideline Recommends Against Arthroscopy for Most Cases of Degenerative Knee Disease – Journal Watch (free) AND Arthroscopic Surgery Doesn’t Help With Arthritis Knee Pain – NPR Health News (free)

 

2 – Internet-Based Vestibular Rehabilitation for Older Adults With Chronic Dizziness: A Randomized Controlled Trial in Primary Care – Annals of Family Medicine (free)

See also: Balance retraining tool used in the study (free)

Commentaries: Online Rehabilitation Program Reduces Chronic Dizziness – Medscape (free registration required) AND Online Intervention Could Reduce Chronic Dizziness – Physician’s First Watch (free)

 

3 – Can Endgame Tobacco radically reduce cigarette smoking? – Healthy Debate (free) (RT @IrfanDhalla see Tweet)

Related: The tobacco endgame: a qualitative review and synthesis – Tobacco Control (free) AND It’s time to focus on an endgame for tobacco regulation – The Conversation (free)

“The “Tobacco Endgame” concept moves thinking away from the mere control of tobacco towards plans for ending the tobacco pandemic, and foresees a tobacco-free future” (from The Conversation)

 

4 – Review: Countering cognitive biases in minimizing low value care – The Medical Journal of Australia (free)

“How cognitive bias affects clinical decision making and what to do about it. Well written & useful” (RT @carissa_bon and @JulieLeask see Tweet)

 

5 – Using AI to Detect Cancer, Not Just Cats – Wired (free) (RT @EricTopol see Tweet)

Related: Is AI a threat or benefit to health workers? – CMAJ News (free)

More on Artificial Intelligence in Healthcare in our April 28Th issue (see #1) and in our April 10th issue (see #8)

 

6 – NCCN Guidelines Insights: Hepatobiliary Cancers, Version 1.2017 (free)

 

7 – Hodgkin Lymphoma Version 1.2017, NCCN Clinical Practice Guidelines in Oncology (free)

 

8 – Enhanced Recovery After Surgery Program Implementation in 2 Surgical Populations in an Integrated Health Care Delivery System – JAMA Surgery (free)

Invited commentary: Enhanced Surgical Recovery Through Enhanced Research From Integrated Health Systems (free)

See also our selection of Enhanced Recovery After Surgery Free Guidelines and Reviews

In this pre-post difference-in-differences study with 20 medical centers and 15849 surgical patients, implementation of ERAS protocols in patients undergoing elective colorectal resection and patients undergoing emergency hip fracture repair were associated with decreases in hospital length of stay and postoperative complication rates.

 

9 – Editorial: Vector control: time for a planetary health approach – The Lancet Global Health (free)

 

10 – Socioeconomic status as an effect modifier of alcohol consumption and harm: analysis of linked cohort data – The Lancet Public Health (free)

Invited commentary: Socioeconomic status and susceptibility to alcohol-related harm (free)

Commentary: Poorest at greater risk from heavy drinking, says study – BBC (free)

 

Tue, May 9 – 10 Medical Stories of The Day!

9May
2017

 

1 – Noncommunicable diseases: the slow-motion disaster – World Health Organization (free)

Related WHO resources: Other dimensions of the NCD crisis: from mental health, ageing, dementia and malnutrition to deaths on the roads, violence and disability (free) AND Tools for implementing WHO PEN (Package of essential noncommunicable disease interventions) (free) AND WHO’s work on NCDs (free)

Source: Noncommunicable Diseases: A Global ‘Slow-Motion Disaster’ – Medscape (free registration required)

 

2 – UN Global Road Safety Week, 8-14 May 2017 – World Health Organization

Press release 1: Fourth UN Global Road Safety Week 2017, 8-14 May 2017 (free)

Press release 2: Speed management key to saving lives, making cities more livable (free)

New WHO Report: Save LIVES: a road safety technical package (free)

WHO campaign: “Road Safety: Around 1.25 million people die every year on the world’s roads. Save lives, Slow Down!” (see Tweet) AND “Global Road Safety week: Excessive or inappropriate speed contributes to 1 in 3 road traffic fatalities, Slow Down!” (see Tweet).

 

3 – Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update from the American College of Physicians – Annals of Internal Medicine (free)

Commentaries: ACP Updates Guidelines on Treating Low Bone Density, Osteoporosis – Physician’s First Watch (free) AND New ACP Guidelines on the Treatment of Osteoporosis  – Medscape (free registration required)

Related guideline: UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free)

 

4 – Review: Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes – Circulation Research (free)

 

5 – Intravenous fluid therapy in adults in hospital – Updated National Institute for Health and Care Excellence (NICE – UK) Guideline (free)

 

6 – Type 2 diabetes in adults: management – Updated National Institute for Health and Care Excellence (NICE – UK) Guideline (free)

 

7 – Missed Opportunities for Deprescription: A Teachable Moment – JAMA Internal Medicine (free)

Related: This physician wants her patients to use fewer medications – The Washington Post (free)

For more on ”Deprescribing” see our May 8th issue, see #4

“Deprescription needs to be prescribed more” (RT @EricTopol see Tweet)

 

8 – Richard Lehman’s weekly review of medical journals – The BMJ Blogs (free)

 

9 – Review: Approach to the Patient with Hematochezia – Mayo Clinic Proceedings (free) (RT @HMVJC)

 

10 – Review: Fever of unknown origin (FUO) revised – Wiener klinische Wochenschrift (free) (RT @HMVJC)

 

Wed, May 10 – 10 Medical Stories of The Day!

10May
2017

 

1 – Screening for Thyroid Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorial 1: The USPSTF Recommendation on Thyroid Cancer Screening: Don’t “Check Your Neck” (free)

Editorial 2: Cancer Screening, Overdiagnosis, and Regulatory Capture (free)

Editorial 3: How to Look for Thyroid Cancer (free)

Commentaries: No Symptoms, No Thyroid Screening, Says USPSTF – Medscape (free registration required) AND Don’t Screen For Thyroid Cancer, Task Force Says – NPR Health News (free) AND USPSTF Says No to Thyroid Cancer Screening – MedPage Today (free registration required)

The USPSTF recommended against screening for thyroid cancer in asymptomatic adults with “grade D” recommendation (Grade D = “The USPSTF recommends against the service. There is moderate or high certainty that the service has no net benefit or that the harms outweigh the benefits”).

 

2 – Meta-analysis: Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study – The BMJ (free)

High intakes of red and processed meat are associated with increased risks of all-cause mortality and death due to nine different causes.

 

3 – Meta-analysis: Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality: dose–response meta-analysis of prospective cohort studies – European Journal of Epidemiology (free)

Source: Eating cheese does not raise risk of heart attack or stroke, study finds – The Guardian (free)

Dairy seems to be neutral regarding risks of cardiovascular diseases and all-cause mortality.

 

4 – Guideline for opioid therapy and chronic noncancer pain – Canadian Medical Association Journal (free) (RT @IrfanDhalla and @jendlake see Tweet)

 

5 – UK clinical practice guidelines for the management of gastrointestinal stromal tumours (GIST) – Clinical Sarcoma Research (free)

 

6 – Guideline for the Management of Fever and Neutropenia in Children With Cancer and Hematopoietic Stem-Cell Transplantation Recipients: 2017 Update (free)

 

7 – Viewpoint: Business Model–Related Conflict of Interests in Medicine: Problems and Potential Solutions – JAMA (free)

Source: Doctors should be paid by salary, not fee-for-service, argue behavioral economists – EurekAlert (free)

 

8 – Insights: Finding the Rare Pathogenic Variants in a Human Genome – JAMA (free)

“Prudent perspective on whole genome sequencing for healthy individuals” (RT @EricTopol see Tweet)

Technology allows sequencing of the entire human genome, but for healthy people, it currently has no clear clinical benefit and is inconsistent with a fundamental clinical axiom—to refrain from seeking uninterpretable and misleading information in patients or healthy individuals” .

 

9 – First opinion: The shadow of Big Tobacco looms over e-cigarettes and harm reduction – STAT News (free)

“Should we settle for lesser harms?”. “Examples of harm reduction strategies include providing methadone to heroin users… opening needle exchanges to prevent the spread of HIV and hepatitis among individual who inject drugs…and promoting e-cigarettes or smokeless tobacco as alternatives to smoking combustible cigarettes”.

 

10 – Postmarket Safety Events Among Novel Therapeutics Approved by the US Food and Drug Administration Between 2001 and 2010 – JAMA (link to abstract – $ for full-text)

Commentaries: Nearly 1 In 3 Recent FDA Drug Approvals Followed By Major Safety Actions – Scientific American (free) AND One in Three Newly Approved Drugs Has Safety Issues – MedPage Today (free registration required) AND Safety Events Common in Newly Approved Drugs – Medscape (free registration required) AND New safety risks detected in one-third of FDA-approved drugs – The Washington Post (free) (RT @EricTopol see Tweet) AND One-Third Of New Drugs Had Safety Problems After FDA Approval – NPR Health News (free)

*Newer is not always better.

 

Mon, May 8 – 10 Medical Stories of The Day!

8May
2017

 

1 – Conflict of Interest Theme Issue – JAMA

Theme Issue – Homepage (free)

Highlights (free)

Editorial: The Complex and Multifaceted Aspects of Conflicts of Interest (free)

Editorial: Conflict of Interest and Medical Journals (free)

Conflict of Interest: Why Does It Matter? (free)

Payments to Physicians: Does the Amount of Money Make a Difference? (free)

Why There Are No “Potential” Conflicts of Interest (free)

Addressing Bias and Conflict of Interest Among Biomedical Researchers (free)

Conflict of Interest and the Integrity of the Medical Profession (free)

Strategies for Addressing a Broader Definition of Conflicts of Interest (free)

Role of Leaders in Fostering Meaningful Collaborations Between Academic Medical Centers and Industry While Also Managing Individual and Institutional Conflicts of Interest (free)

Conflict of Interest Among Medical School Faculty: Achieving a Coherent and Objective Approach (free)

Teaching Medical Students About Conflicts of Interest (free)

Funding, Institutional Conflicts of Interest, and Schools of Public Health: Realities and Solutions (free)

Conflicts of Interest and Professional Medical Associations: Progress and Remaining Challenges (free)

Conflict of Interest in Practice Guidelines Panels (free)

Financial Conflicts of Interest in Continuing Medical Education: Implications and Accountability (free)

Challenges and Opportunities in Disclosing Financial Interests to Patients (free)

Business Model–Related Conflict of Interests in Medicine: Problems and Potential Solutions (free)

What Do Patients Think About Physicians’ Conflicts of Interest? Watching Transparency Evolve (free)

Public Disclosure of Payments to Physicians From Industry (free)

Managing Conflicts of Interest in Industry-Sponsored Clinical Research: More Physician Engagement Is Required (free)

Physicians, Industry Payments for Food and Beverages, and Drug Prescribing (free)

Conflict of Interest and the Role of the Food Industry in Nutrition Research (free)

How Should Journals Handle the Conflict of Interest of Their Editors? Who Watches the “Watchers”? (free)

Medical Journals, Publishers, and Conflict of Interest (free)

Conflict of Interest and Legal Issues for Investigators and Authors (free)

Is There a Conflict of Interest? (free)

 

2 – Research letter: Applicability of the IMPROVE-IT Trial to Current Patients With Acute Coronary Syndrome – JAMA Internal Medicine (link to abstract – $ for full text)

Source: Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today (free registration required)

Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)

Patients in clinical trials are often younger, healthier (with less comorbidities), better plugged in to the health care system, better educated and wealthier, indicating that the external validity or generalizability of much of the current evidence to real-world settings may be relatively weak.

 

3 – Medical News & Perspectives: The Paternal Epigenome Makes Its Mark – JAMA (free)

Related: Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype – American Journal of Stem Cells (free)

“Epigenetic changes may be the underlying mechanism by which paternal factors such as age, diet, weight, stress, and alcohol consumption contribute to a range of health outcomes in offspring including birth defects, behavioral problems, developmental disorders, obesity, diabetes, cardiovascular disease, and cancer”.

 

4 – Reducing inappropriate prescribing easier said than done – CMAJ News (free)

Related: Canadian Deprescribing Network (CaDeN) (free)

AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free)

 

5 – USPSTF recommendations: A 2017 roundup – Journal of Family Practice

 

6 – Multiple myeloma: ESMO Clinical Practice Guidelines for diagnosis, treatment and follow-up – Annals of Oncology (free)

 

7 – Guidelines for Management of Incidental Pulmonary Nodules Detected on CT Images: From the Fleischner Society 2017 – Radiology (free)

Source: Management of Pulmonary Nodules Found Incidentally on Computed Tomography Scans – Journal Watch (free)

Incidental pulmonary nodules discovered outside the context of screening or cancer follow-up are increasingly common in clinical practice. The purpose of these updated recommendations is to reduce the number of unnecessary follow-up examinations while providing practical guidance on follow-up intervals for selected larger nodules.

 

8 – CDC updates Zika test guidance for pregnant women – CIDRAP (free)

Centers for Disease Control and Prevention (CDC) related resources: CDC Zika Interim Response Plan (free) (RT @greg_folkers) AND CDC updates guidance on interpretation of Zika testing results for pregnant women AND Outcomes of Pregnancies with Laboratory Evidence of Possible Zika Virus Infection in the United States AND Prolonged IgM Antibody Response in People Infected with Zika Virus: Implications for Interpreting Serologic Testing Results for Pregnant Women (free)

 

9 – Series: Acute Kidney Injury in the Intensive Care Unit

Fluid management in acute kidney injury – Intensive Care Medicine (free PDF)

Renal recovery after acute kidney injury – Intensive Care Medicine (free)

Diagnostic work-up and specific causes of acute kidney injury – Intensive Care Medicine (free PDF)

Acute kidney injury in the ICU: from injury to recovery: reports from the 5th Paris International Conference – Annals of Intensive Care (free)

Source: Critical Care Reviews Newsletter

 

10 – Management of severe perioperative bleeding: guidelines from the European Society of Anaesthesiology (free)

Source: Critical Care Reviews Newsletter

 

Fri, May 5 – 10 Medical Stories of The Day!

5May
2017

 

1 – Centers for Disease Control and Prevention Guideline for the Prevention of Surgical Site Infection, 2017 – JAMA Surgery (free) (RT @jankluytmans and @CIDRAP_ASP see Tweet)

Invited commentary: Surgical Site Infection Prevention – What We Know and What We Do Not Know – JAMA Surgery (free)

Commentary: ‘Long-Awaited’ CDC Guidelines on SSI Prevention Released – Medscape (free registration required)

Related: Global guidelines on the prevention of surgical site infection 2016 – World Health Organization (free)

 

2 – World Hand Hygiene Day (May 5th, 2017)

World Health Organization: SAVE LIVES: Clean Your Hands 5 May 2017 AND Campaign Resources

Centers for Disease Control and Prevention (CDC): Clean Hands Count Campaign (free) AND Hand Hygiene in Healthcare Settings (free)

 

3 – First opinion: 8 things that excellent hospital doctors do – STAT News (free)

 

4 – Multiple-micronutrient supplementation for women during pregnancy – Cochrane Library (free summary – $ for full-text)

See also a recent landmark study on the subject in our March 27th issue, see #9.

Source: EvidenceAlerts

The findings of this systematic review support the effect of Multiple-micronutrient supplements with iron and folic acid in improving some birth outcomes.

 

5 – The World Is Not Ready for the Next Pandemic – TIME cover story (RT @HealthTalkUMN and @paimadhu see Tweet)

Related: The World Is Completely Unprepared for a Global Pandemic – Harvard Business Review (free) Seven reasons we’re at more risk than ever of a global pandemic – CNN (free)

 

6 – Handheld screen time linked with speech delays in young children – ScienceDaily (free)

Commentary on text and video: Letting a baby play on an iPad might lead to speech delays, study says – CNN (free)

See also more on the subject and screen time recommendations from the American College of Pediatrics in our April 10th issue, see #6.

“New research being presented at the 2017 Pediatric Academic Societies Meeting suggests the more time children under 2 years old spend playing with smartphones, tablets and other handheld screens, the more likely they are to begin talking later” (from ScienceDaily).

 

7 – Randomized controlled trial: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial – The Lancet (free)

Invited commentary: Weight management programmes of extended duration – The Lancet (free)

Commentary: Give overweight patients a year of weight-loss classes, say researchers – The Guardian (free)

In this trial with 1,267 overweight or obese participants an extended weight loss program (1 year) was more effective for weight loss and seems cost-effective in the longer term.

 

8 – Association of Donor Age and Sex With Survival of Patients Receiving Transfusions – JAMA Internal Medicine (link to abstract – $ required for full-text)

Source: Blood Donor Age, Sex Do Not Affect Outcomes After All – Medscape (free registration required)

After reviewing almost 1 million transfusions, the researchers concluded all donations are about the same” (RT @theheartorg see Tweet)

 

9 – Editor’s Choice: Give patients access to their medical records – The BMJ, by Fiona Godlee, editor in chief (free)

Patients are being empowered in decisions regarding their health care, and this is probably a tendency for the future.

 

10 – Correspondence: Trial of Transplantation of HCV-Infected Kidneys into Uninfected Recipients – The New England Journal of Medicine (free)

Transplantation of HCV-infected-kidneys into uninfected recipients seems feasible in this era of direct-acting antiviral agents, maybe shortening waiting times for those willing to take the risk.

 

Thu, May 4 – 10 Medical Stories of The Day!

4May
2017

 

1 – Selection of patients for intra-arterial treatment for acute ischaemic stroke: development and validation of a clinical decision tool in two randomised trials – The BMJ (free)

New decision tool: MR CLEAN-R Registry (free)

This new clinical decision tool will improve the selection of patients with acute ischemic stroke who will benefit the most from intra-arterial treatment.

 

2 – Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (Link to abstract – $ for full-text)

Quick Take Video Summary: Bystander Efforts in Out-of-Hospital Cardiac Arrest (free)

Commentary: Bystander CPR and Defibrillation Are Associated with Better Long-Term Outcomes – Journal Watch (free)

In patients who have initially survived after out-of-hospital cardiac arrest, those who were submitted to bystander CPR and defibrillation had lower risk of brain damage, nursing home admission and death after one year when compared to patients who survived but were not submitted to bystander CPR.

 

3 – As scientists take to Twitter, study shows power of ‘visual abstract’ graphics – Scienmag (free) (RT @jdimick1 @UM_IHPI)

Have a look: Example of visual abstract and its benefits for engagement (Tweet)

Original article ($ for full-text): Visual Abstracts to Disseminate Research on Social Media: A Prospective, Case-control Crossover Study – Annals of Surgery

See also: an open-source primer on visual abstracts (free)

This new tendency might increase engagement with medical research.

 

4 – Cardiology groups issue guidance on heart failure – ACP Hospitalist

Key points from the recently published AHA Heart Failure Guideline (free)

See also our coverage on the new guidelines on our May 1st issue, see #2.

 

5 – Association Between Academic Medical Center Pharmaceutical Detailing Policies and Physician Prescribing – JAMA (link to abstract – $ for full-text)

Commentaries: Doctors Prescribe More Generics When Drug Reps Are Kept At Bay – NPR (free) AND Limiting Interactions with Pharma Reps Cuts Brand Name Drug Prescriptions – Physician’s First Watch (free)

See more about conflicts of interest in medicine in our yesterday’s issue, see #10.

 

6 – Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study – The BMJ (free)

Commentary: Gluten-Restricted Diets Seem Not to Lower Coronary Risk – Physician’s First Watch (free)

 

7 – Viewpoint: Breaking the Rules for Better Care – JAMA (free) (RT @gmacscotlan)

“Administrative burdens and complexity are alleged to be among the most costly forms of waste in US health care”. This comentary addresses the problem and provide a few suggestions for better care.

See more about the burden of administrative tasks in healthcare in our April 21st issue, see #5, and about physician’s burnout and clerical work in our April 24th issue, see #9.

 

8 – Interesting read: The Death of Expertise – The Federalist (free) (RT @wellcometrust and @MaryDixonWoods see Tweet)

This interesting commentary may as well be applied to the changing relationships between patients and doctors.

 

9 – Statins, Like All Medicines, Are Neither Good Nor Bad – By John Mandrola, MD (free)

I am sick of the “bad” drug frame. My latest fast-writing: Statins, Like All Medicines, Are Neither Good Nor Bad” (RT @drjohnm see Tweet)

 

10 – Urinary catheter care: what does the evidence say? – Cochrane Library (free)

How frequently should indwelling urinary catheters be changed? Are catheter washouts effective? Which type of catheter reduces rates of urinary tract infection?”. This post look at the evidence regarding urinary catheter care.

 

Wed, May 3 – 10 Medical Stories of The Day!

3May
2017

 

1 – World Asthma Day (May 2, 2017): Asthma Updated Fact Sheet – World Health Organization (free)

Related:  Cochrane Evidence resources related to World Asthma Day (free summaries)

 

2 – Report: Preventing drowning: an implementation guide – World Health Organization (free) (See @WHO Tweet 1 and Tweet 2)

Related publication: Global report on drowning: preventing a leading killer – World Health Organization (free)

 

3 – Embrace the facts about vaccines, not the myths – World Health Organization (free) (RT @gmacscotland see Tweet)

Related: The amazing power of vaccines, explained in 6 seconds – World Economic Forum (free) AND World Immunisation Week: The Rise of Anti-Vaccine Movement and What it Means for Public Health – Independent (free) (RT @LSHTMpress see Tweet)

See also our coverage on World Immunization Week in our April 25 issue, see #1.

 

4 – What is public health? Some reflections for teaching – Dr Graham Mackenzie, Consultant in Public Health (free)

 

5 – Systematic review: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library (free summary – $ for full-text))

The evidence so far suggests that PCSK9 inhibitor use probably leads to little or no difference in mortality and leads to a modest absolute risk reduction (often less than 1%) in cardiovascular events in high-risk patients.

 

6 – Effect of Alternate-Day Fasting on Weight Loss, Weight Maintenance, and Cardioprotection Among Metabolically Healthy Obese Adults: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Commentaries: Fasting Studies Clash With Our Desire To Eat What We Want, When We Want It – NPR Health News (free) AND Fasting Every Other Day Does Not Lead to Greater Weight Loss – Physician’s First Watch (free) AND Same Weight Loss With Alternate-Day Fasting vs Cutting Calories – Medscape (free registration required) AND Alternate-Day Fasting Doesn’t Lead to Speedier Weight Loss – MedPage Today (free registration required)

Randomized trial with 100 patients showed no difference in weight loss between alternate-day fasting versus calorie restriction.

 

7 – Updated Guidelines for the Use of Antiretroviral Agents in Pediatric HIV Infection – AIDSInfo (free)

 

8 – Second-Line Hormonal Therapy for Men With Chemotherapy-Naïve, Castration-Resistant Prostate Cancer: American Society of Clinical Oncology Provisional Clinical Opinion (free)

Source: ASCO Issues Guideline on Castrate-Resistant Prostate Cancer – Medscape (free registration required)

 

9 – Interesting read: Here’s What Your Future Doctor Visits Could Look Like – Fortune (free) (RT @EricTopol see Tweet)

According to this point of view “tomorrow’s office visit will increasingly take place everywhere but the office”, with a sharp increase in virtual visits and home visits, with doctors coming to patients.

 

10 – Viewpoint: Conflict of Interest: Why Does It Matter? – JAMA (free)

Editorial 1: The Complex and Multifaceted Aspects of Conflicts of Interest (free)

Editorial 2: Conflict of Interest and Medical Journals (free)

Source: Bruno Besen, MD

 

Tue, May 2 – 10 Medical Stories of The Day!

2May
2017

 

1 – Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free) (RT @CMAJ see Tweet)

Commentary: Use of Certain Antibiotics in Pregnancy Tied to Spontaneous Abortion – Physician’s First Watch (free)

In this nested case-control study, use of common antibiotics such as macrolides (excluding erythromycin), quinolones, tetracyclines, sulfonamides and metronidazole during early pregnancy was associated with an increased risk of spontaneous abortion.

 

2 – Effect of Using the HEART Score in Patients With Chest Pain in the Emergency Department: A Stepped-Wedge, Cluster Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

See also: HEART Score for Major Cardiac Events – MdCalc (free)

Commentaries: HEART Score for Chest Pain in ED Found to Be Safe, Cost-Effective – Physician’s First Watch (free) AND HEART Score Safely Informs Chest Pain Decisions in ED – Medscape (free registration required) AND HEART score to risk stratify patients with chest pain is safe but underutilized in the ED – ScienceDaily (free)

 

3 – Just started. Essentials of Global Health – Free Online Course from the Yale University and Coursera (RT @glassmanamanda)

 

4 – Expert consensus document: Echocardiography and lung ultrasonography for the assessment and management of acute heart failure – Nature Reviews Cardiology (free)

Source: Critical Care Reviews Newsletter

 

5 – Short review: CPAP Use in Obstructive Sleep Apnea: What a Cardiologist Needs to Know – American College of Cardiology, Latest in Cardiology (free)

 

6 – Review: Acute Respiratory Distress Syndrome – European Respiratory Review (free)

 

7 – Women with symptoms of a urinary tract infection but a negative urine culture: PCR-based quantification of Escherichia coli suggests infection in most cases – Clinical Microbiology and Infection (link to abstract – Free and legal PDF here – via @unpaywall)

Sources: The most reliable test and predictive entity for uncomplicated UTI is the patient’s symptoms – Emergency Literature of Note Blog (free) AND Negative Urine Culture + Symptoms = UTI in Most Women – MedPage Today (free registration required)

This study suggests that women with symptoms of uncomplicated cystitis and a negative urinary culture should be treated nonetheless.

 

8 – Prevalence of multidrug-resistant gram-negative bacteria among nursing home residents: A systematic review and meta-analysis – American Journal of Infection Control (free)

Sources: Study: Resistant gram-negative bacteria common in nursing homes – CIDRAP (free) (RT @IDSAInfo see Tweet) AND A quarter of nursing home residents are colonized with drug-resistant bacteria – EurekAlert (free)

 

9 – For Pregnant Women, Getting Serious About Whooping Cough – The New York Times (10 articles per month are free)

Related: Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis – Pediatrics (free) AND Study: Pertussis shot in pregnant moms protects newborns – CIDRAP (free) AND Get the Whooping Cough Vaccine While You Are Pregnant – Centers for Disease Control and Prevention (CDC) (free)

 

10 – More Evidence that Excessive Blood Pressure Lowering Can Heighten Cardiovascular Risk – Journal Watch (free)

Original article abstract ($ for full-text): Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials – The Lancet

See more about this article in our April 11 issue, see #8.

 

Mon, May 1 – 10 Medical Stories of The Day!

1May
2017

 

1 – Guidelines for treatment of drug-susceptible tuberculosis and patient care (2017 update) – World Health Organization (free) (RT @paimadhu see Tweet)

 

2 – 2017 ACC/AHA/HFSA Focused Update of the 2013 ACCF/AHA Guideline for the Management of Heart Failure (free)

Commentaries: Societies Update Heart Failure Management Guidelines – Heart Failure Society of America (free) AND Societies Release HF Guideline Focused Update – American College of Cardiology, Latest in Cardiology (free)

 

3 – UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free)

 

4 – Adjuvant Systemic Therapy and Adjuvant Radiation Therapy for Stage I to IIIA Completely Resected Non–Small-Cell Lung Cancers: American Society of Clinical Oncology/Cancer Care Ontario Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

 

5 – Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association (free PDF)

News release: New guidance on heart failure tests can improve care – American Heart Association News (free)

 

6 – Management of Inherited Bleeding Disorders in Pregnancy: Green-top Guideline – Royal College of Obstetricians and Gynaecologists (free)

 

7 – Guidelines for the Economic Evaluation of Health Technologies: Canada – 4th Edition – Canadian Agency for Drugs and Technologies in Health (free)

News release: Guidelines for the Economic Evaluation of Health Technologies (free)

Commentary: New guidelines for evaluating health tech: New guide for economic analysis of drugs and technology – CMAJ News (free)

Best practices guidelines for conducting economic evaluations of health care technologies, so that the information produced is standardized and of high quality and can effectively inform health care decision-making.

 

8 – Screening for Preeclampsia: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Evidence Report and Systematic Review: Preeclampsia Screening (free)

Editorial 1: Early Identification of Pregnant Women at Risk for Preeclampsia (free)

Editorial 2: Screening for Preeclampsia and the USPSTF Recommendations (free)

Editorial 3: Preeclampsia and Hypertension – Courting a Long While: Time to Make It Official (free)

“The USPSTF recommends screening for preeclampsia in all pregnant women with blood pressure measurements throughout pregnancy”

 

9 – Practice guideline summary: Sudden unexpected death in epilepsy incidence rates and risk factors: Report of the Guideline Development, Dissemination, and Implementation Subcommittee of the American Academy of Neurology and the American Epilepsy Society (free)

Editorial: Gaining perspective on SUDEP: The new guideline (free)

Commentary: New guideline: Address GTCS frequency to reduce SUDEP risk – Clinical Neurology News (free)

 

10 – Management of Aromatase Inhibitor-Associated Bone Loss (AIBL) in postmenopausal women with hormone sensitive breast cancer: Joint position statement of the IOF, CABS, ECTS, IEG, ESCEO, IMS, and SIOG (free)

News release: New guidance for management of aromatase-inhibitor related bone loss in breast cancer – Internationa Osteoporosis Foundation (free)

Source: Guidelines Issued on Managing Bone Loss Tied to Aromatase Inhibitor Therapy – Physician’s First Watch (free)

 

Fri, Apr 28 – Top 10 Medical News Stories!

28Apr
2017

 

1 – Automated Identification of Diabetic Retinopathy Using Deep Learning – Ophthalmology (free)

Source: Artificial Intelligence Shows Potential to Fight Blindness – NewsWise (free)

Related article: Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs – JAMA (link to abstract -$ for full-text)

Another study showing an artificial intelligence-based algorithm can be used with high reliability to screen for diabetic retinopathy, with cases referred to an ophthalmologist for further evaluation and treatment.

See more about how doctors might be affected by artificial intelligence in our April 10 issue, see #8.

 

2 – Text and video: The riskiest vaccine? The one that is not given – Science (free) (RT @greg_folkers)

 

3 – Systematic review: Tobacco packaging design for reducing tobacco use – Cochrane Library (link to summary – $ for full-text)

News release: Standardised tobacco packaging: will banning branding cut down smoking? (free)

See also: Standardised cigarette packaging is on its way, but will it reduce smoking? – The Guardian (free)

New evidence finds standardized cigarette packaging may reduce the number of people who smoke.

 

4 – A better way to care for the dying – The Economist (free) (RT @EricTopol see Tweet)

“How the medical profession is starting to move beyond fighting death to easing it”.

 

5 – Normal-Weight Central Obesity and Risk for Mortality – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Waist circumference stronger predictor of death risk than BMI – Haelio (free) AND Forget Your BMI and Focus on This Measurement Instead – TIME (free) AND Central Obesity Ups Mortality Across BMI Range – Physician’s Briefing (free) AND Central obesity may increase mortality risk from cardiovascular disease – Cardiovascular Business (free) AND People with a normal BMI who carry weight around the middle at greatest risk of death – HealthCanal (free)

 

6 – Advil, Motrin and other NSAIDs painkillers should be prescription only, Danish study says – Pittsburgh Post-Gazette (free) (RT @medpagetoday see Tweet)

Original article: Non-steroidal anti-inflammatory drug use is associated with increased risk of out-of-hospital cardiac arrest: a nationwide case–time–control study – European Heart Journal – Cardiovascular Pharmacotherapy (free)

See more commentaries on this study in our March 17 issue, see #5.

 

7 – Mortality risk during and after opioid substitution treatment: systematic review and meta-analysis of cohort studies – The BMJ (free)

Editorial: Opioid substitution treatment is linked to reduced risk of death in opioid use disorder – The BMJ (free)

Commentary: Opioid Substitution Therapy Associated with Reduced Mortality – Physician’s First Watch (free)

Opioid substitution treatment seems to be associated with decreased mortality.

 

8 – Viewpoint: Should we abandon routine blood tests? – The BMJ Opinion (free)

The practice of ordering routine blood tests for patients attending hospital regardless of clinical need is wasteful and potentially damaging, argue three doctors”.

 

9 – Viewpoint: Universal health coverage, priority setting, and the human right to health – The Lancet (free registration required)

 

10 – Sepsis can send a child to the brink of death within hours. A new coalition of hospitals is fighting back – STAT News (free)

 

Thu, Apr 27 – 10 Medical Stories of The Day!

27Apr
2017

 

1 – Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial – The Lancet (free)

Editorial: WOMAN: reducing maternal deaths with tranexamic acid (free)

Commentary: Overlooked Drug Could Save Thousands Of Moms After Childbirth – NPR Goats and Soda (free)

“Tranexamic acid reduced deaths of mothers caused by bleeding after childbirth by 1/3” (RT @LSHTMpress see Tweet)

 

2 – Guideline: Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure: A Scientific Statement From the American Heart Association (free PDF)

News release: New guidance on heart failure tests can improve care – American Heart Association News (free)

 

3 – Editorial: Saturated fat does not clog the arteries: coronary heart disease is a chronic inflammatory condition, the risk of which can be effectively reduced from healthy lifestyle interventions – British Journal of Sports Medicine (free)

Commentaries on the editorial: Does saturated fats clog your arteries? Controversial paper says ‘no’ – CNN (free) AND The Battle Over the Causes of Cardiovascular Disease Heats Up! – By George Henderson and Grant Schofield (free) AND Backlash after report claims saturated fats do not increase heart risk – The Guardian (free) AND Expert reaction to editorial on saturated fat and heart disease – Science Media Centre (free)

Fat wars continue. New interesting but controversial editorial heats up the debate.

 

4 – Guidelines For Management Of Dyslipidemia And Prevention Of Cardiovascular Disease – American Association Of Clinical Endocrinologists And American College Of Endocrinology (free PDF) (RT @greg_folkers)

 

5 – Adherence to High-Intensity Statins Following a Myocardial Infarction Hospitalization Among Medicare Beneficiaries – JAMA Cardiology (link to abstract – $ for full-text)

Source: Heart Attack Survivors Often Fail to Take Statins – The New York Times (free)

In this cohort only 41.6% of patients aged 66 to 75 years continued taking statins as prescribed at 2 years.

 

6 – Five years wisely: A look at Choosing Wisely’s effort to reduce unnecessary medical care – HealthNewsReview (free) (RT @pash22 and @glassmanamanda see Tweet)

See also: Choosing Wisely initiative was launched 5 years ago in our April 5 issue.

 

7 – How to Fight Cancer (When Cancer Fights Back) – The Atlantic (free)

“Understanding how the disease evolves is the key to stopping it”.

 

8 – How hype can mislead cancer patients, families – CNN (free)

Related: Financial toxicity: 1 in 3 cancer patients have to turn to friends or family to pay for care – STAT News (free) AND Not Just Nausea And Vomiting: Cancer Docs Now Worry About ‘Financial Toxicity’ – WBUR (free)

“Cancer cost crisis forces tough choices”.

 

9 – Alcohol consumption, sinus tachycardia, and cardiac arrhythmias at the Munich Octoberfest: results from the Munich Beer Related Electrocardiogram Workup Study (MunichBREW) – European Heart Journal (free)

Sources: Alcohol binge can upset heart’s rhythm, say researchers – BBC Health News (free) AND Binge Drinkers Beware: Study Finds Link Between Alcohol And Heart Arrhythmias – NPR (free) AND Oktoberfest: Downing Beers, Raising Heart Rates – Acute measurement in beer tents shows high rate of sinus tachycardia – MedPage Today (free registration required)

 

10 – After Knee or Hip Replacement, No Place Like Home – The New York Times (10 articles per month are free)

See also: Time to Rethink Inpatient Rehab After Knee Replacement? – The Rheumatologist (free)

Original article abstract ($ for full-text): Effect of Inpatient Rehabilitation vs a Monitored Home-Based Program on Mobility in Patients With Total Knee Arthroplasty: The HIHO Randomized Clinical Trial – JAMA (free)

The NYT commentary talks about the futility of some interventions currently used to postpone surgery and about the benefits of outpatient rehabilitation.

 

Tue, Apr 25 – 10 Medical Stories of The Day!

25Apr
2017

 

1 – World Immunization Week, 24-30 April 2017 – World Health Organization (free)

Press release: World Immunization Week 2017 (free)

See also: WHO’s work on immunization (free)

“Increasing immunization globally could save an additional 1.5 million people every year”.

 

2 – Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy – The Lancet (free registration required)

Chronic kidney disease is increasingly recognized as a global public health problem affecting as many as 10–15% of the population worldwide. It is associated with impaired quality of life and strongly reduced life expectancy. The article identifies key activities for the next 5-10 years to address the problem.

 

3 – Guideline: Community Mitigation Guidelines to Prevent Pandemic Influenza – United States, 2017 – CDC – MMWR (free)

Source: New CDC guidelines on flu pandemic measures reflect 2009 lessons – CIDRAP (free)

These new guidelines focus on nonpharmaceutical measures to fight and prevent influenza pandemics.

 

4 – Guideline: Recommendations on hepatitis C screening for adults – Canadian Task Force on Preventive Health Care (free)

News release: CTFPHC Releases Its First Hepatitis C Population-wide Screening Guideline (free)

See also: Summary of recommendations for clinicians and policy-makers (free) AND Clinician FAQ (free)

Commentary: Canada recommends against testing everyone for hepatitis C – Reuters Health (free) (RT @CMichaelGibson)

“Guideline recommends against screening for HCV in adults who are not at elevated risk”.

 

5 – Nursery Product-Related Injuries Treated in United States Emergency Departments – Pediatrics (free)

Source: Common Nursery Products Send Thousands of Children to Hospitals – The New York Times (10 articles per month are free) (RT @CMichaelGibson)

Baby carriers, mattresses, strollers, high chairs, changing tables, bath seats and other ordinary nursery products lead to injuries and emergency room visits for 66,000 children a year in U.S.

 

6 – Spend a Dollar on Drug Treatment, and Save More on Crime Reduction – The New York Times (10 articles per month are free)

 

7 – Committee Opinion: Hormone Therapy in Primary Ovarian Insufficiency – American College of Obstetricians and Gynecologists (free)

Source: Group Offers Guidance on Treating Primary Ovarian Insufficiency with Hormone Therapy – Physician’s First Watch (free)

 

8 – Empyema Guidelines Published – Physician’s First Watch (free)

Original article ($ for full-text): The American Association for Thoracic Surgery consensus guidelines for the management of empyema

 

9 – Richard Lehman’s weekly review of medical journals, 24 April 2017 – The BMJ Blogs (free)

 

10 – Relationship between hospital ward design and healthcare-associated infection rates: a systematic review and meta-analysis – Antimicrobial Resistance & Infection Control (RT @brhospitalist and @PreetiNMalani see Tweet)

Single-patient rooms and easily accessible hand rub dispensers located near the patient’s bed are the most effective measures.

 

Wed, Apr 26 – 10 Medical Stories of The Day!

26Apr
2017

 

1 – World Malaria Day, 25 April 2017 – World Health Organization (free)

Press release: Prevent malaria – save lives: WHO push for prevention on World Malaria Day, 25th April (free)

WHO Reports 2017: A framework for malaria elimination (free) AND Malaria prevention works: let’s close the gap – World Malaria Day 2017 (free)

See also: WHO’s work on malaria (free)

Related: Mapping the End of Malaria – Gates Notes (free) (RT @glassmanamanda and @BillGates see Tweet) AND 7 Good Reads For #WorldMalariaDay – NPR Goats and Soda (free) AND Editorial: Is malaria elimination within reach? – The Lancet Infectious Diseases (free)

 

2 – Guideline: Screening for Preeclampsia: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Evidence Report and Systematic Review: Preeclampsia Screening (free)

Editorial 1: Early Identification of Pregnant Women at Risk for Preeclampsia (free)

Editorial 2: Screening for Preeclampsia and the USPSTF Recommendations (free)

Editorial 3: Preeclampsia and Hypertension – Courting a Long While: Time to Make It Official (free)

“The USPSTF recommends screening for preeclampsia in all pregnant women with blood pressure measurements throughout pregnancy”

 

3 – Eat, Sleep, Repeat: How Kids’ Daily Routines Can Help Prevent Obesity – NPR (free)

Observational data suggests regular evening meals, limited screen-viewing time and sleep routine may help prevent obesity in children.

 

4 – Updated Guideline: Prevention and Management of Cardiovascular Disease Risk in Primary Care – Toward Optimized Practice (TOP) Guidelines (free)

Practical guideline for primary care providers.

 

5 – Meta-analysis: Exercise interventions for cognitive function in adults older than 50: a systematic review with meta-analysis – British Journal of Sports Medicine (free)

Source: Exercise Could Benefit Cognition in Older Adults – Physician’s First Watch (free)

“Physical exercise interventions significantly improved cognitive function in adults older than 50 years, regardless of baseline cognitive status”.

 

6 – Accuracy of PECARN, CATCH, and CHALICE head injury decision rules in children: a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Sources: External Validation of Three Decision Rules for Pediatric Head Injury – Journal Watch (free) AND Best way to diagnose head injuries in children and minimize CT scans – ScienceDaily (free) AND PECARN, CATCH, CHALICE … or None of the Above? – By Ryan P. Radecki, MD, in Emergency Medicine Literature of Note (free)

The 3 decision rules performed well with negative predictive values >99%. The PECARN clinical decision rule was more sensitive and missed only 1 patient with clinically important traumatic brain injury, but was less specific, meaning more CTs would be required. These findings indicate that CT can generally be avoided if one of the prediction rules are negative.

 

7 – Cohort study: Use of azithromycin and risk of ventricular arrhythmia – Canadian Medical Association Journal (free)

Source: No Major Azithromycin Arrhythmia Risk in Huge European Cohort – Medscape (free registration required)

Contradicting a previous study (free) and a 2013 safety warning from the US Food and Drug Administration (free), this large cohort did not show an association between azithromycin and ventricular arrhythmia when compared to amoxicillin.

 

8 – Review: Aneurysmal Subarachnoid Hemorrhage: Diagnosis and Treatment – Deutsches Ärzteblatt international (free)

Source: Critical Care Reviews Newsletter (free)

 

9 – With yellow fever reaching Rio, official says Brazil prepared – CIDRAP (free)

 

10 – Assessment of Global Kidney Health Care Status – JAMA (free)

Source: One in 10 People Worldwide Have Chronic Kidney Disease – Medscape (free registration required)

Related: Global kidney health 2017 and beyond: a roadmap for closing gaps in care, research, and policy – The Lancet (free registration required)

 

Mon, Apr 24 – 10 Medical Stories of The Day!

24Apr
2017

 

1 – Report: Global hepatitis report, 2017 – World Health Organization (free)

Press release: New hepatitis data highlight need for urgent global response (free)

Related resources: WHO’s work on Hepatitis (free) AND Global health sector strategy on viral hepatitis, 2016-2021 (free)

The World Health Organization has released the first ever Global Hepatitis Report, with estimates on Hepatitis B and C burden, incidence and mortality. According to the report, deaths from viral hepatitis are increasing, with 1.34 million deaths in 2015, a number comparable to deaths caused by tuberculosis and HIV.

 

2 – FDA Safety Alert: Codeine and Tramadol Medicines: Drug Safety Communication – Restricting Use in Children, Recommending Against Use in Breastfeeding Women (free)

FDA Statement: New warnings about the use of codeine and tramadol in children & nursing mothers (free)

Commentaries on the statement: FDA: Codeine Now Contraindicated for Pain and Cough in Kids – Physician’s First Watch (free) AND Codeine cough syrup should not be given to kids, FDA warns – STAT News (free)

These drugs should not be used at all for children younger than 12 years, and their use should also be limited in some older children.

 

3 – Prospective cohort study: Sugar- and Artificially Sweetened Beverages and the Risks of Incident Stroke and Dementia – Stroke (free PDF)

Editorial: Sugar-Sweetened and Artificially Sweetened Beverages in Relation to Stroke and Dementia: Are Soft Drinks Hard on the Brain? – Stroke (free PDF)

Commentaries on the study: Diet soda and stroke & dementia news coverage: 3 key points weren’t always reported – HealthNewsReview (free – See Tweet) AND Stroke and dementia risk linked to artificial sweeteners, study suggests – The Guardian (free) AND A diet soda a day might affect dementia risk, study suggests – American Heart Association News (free)

This study has drawn a lot of attention from the media, but no firm conclusions can be made due to the observational nature of the study.

 

4 – Perspective: Focusing on High-Cost Patients — The Key to Addressing High Costs? – NEJM Catalyst (free) (RT @brhospitalist)

Related commentaries: Caring for High-Need, High-Cost Patients — An Urgent Priority – New England Journal of Medicine (free) AND Richard Smith: The challenge of high need, high cost patients – The BMJ Blogs (free) 

Playbook: Better Care for People with Complex Needs – Institute for Healthcare Improvement (free)

 

5 – Two new articles in The Lancet address important issues in global health economics.

Article 1: Evolution and patterns of global health financing 1995–2014: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries – The Lancet (free)

Article 2: Future and potential spending on health 2015–40: development assistance for health, and government, prepaid private, and out-of-pocket health spending in 184 countries – The Lancet (free)

Invited commentary: Patterns of global health financing and potential future spending on health – The Lancet (free)

Commentary on the studies: What Country Spends the Most (And Least) On Health Care Per Person? – NPR Goats and Soda (free)

 

6 – Systematic review: Effect of Weight Reduction on Hemoglobin A1c in weight loss trials of Type 2 Diabetes Patients – Diabetes, Obesity and Metabolism (link to abstract – $ for full-text)

“Each 1kg reduction in weight loss trials associated with 0.1% reduction in HbA1c” (RT @kamleshkhunti see Tweet)

 

7 – Short review: Statistical significance vs. clinical significance – Students 4 Best Evidence Blog (free) (RT @CochraneUK see Tweet)

Related review: Reporting the findings: Absolute vs relative risk – HealthNewsReview (free) (See Tweet)

 

8 – Prospective, before-after cohort study: Standardized Criteria for Palliative Care Consultation on a Solid Tumor Oncology Service Reduces Downstream Health Care Use – Journal of Oncology Practice (free)

Editorial: Making the Right Thing Easier to Do: Standardized Integration of Oncology and Palliative Care – Journal of Oncology Practice (free)

Related Guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Commentaries on the study: Standardized Palliative Care Consults Cut Cancer Readmissions – Also, less chemotherapy after discharge – MedPage Today (free registration required) AND Standardized Cancer Palliative Care Consults Linked to Stronger Home-Based Support – AJMC (free)

Patients with at least one of the following 4 criteria: 1) advanced solid tumor; 2) prior hospitalization within 30 days; 3) hospitalization > 7 days; or 4) active symptoms – received automatic palliative care consultation. The rates of 30-day readmissions dropped from 35% to 18% and chemotherapy after discharge dropped from 44% to 18%.

 

9 – Survey and commentaries: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free)

Increased in clerical burden seems to be one of the leading causes, heavily influenced by expanded and more comprehensive use of electronic health records. More on the burden of administrative tasks in healthcare in our April 21 issue, see #5.

 

10 – Review: The efficacy of bedside chest ultrasound: from accuracy to outcomes – European Respiratory Review (free)

 

Fri, Apr 21 – Top 10 Medical News Stories!

21Apr
2017

 

1 – Frequency of Evidence-Based Screening for Retinopathy in Type 1 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

See also: Researchers Propose Extending Diabetic Retinopathy Screening Interval – Physician’s First Watch (free) AND Research from long-term study advocates individualized eye screenings in type 1 diabetes – Diabetes.co.uk (free)

In patients who have had type 1 diabetes for 5 years, annual retinal examinations are currently recommended. Based on their findings, the authors suggest an individualized screening schedule, with less frequent screening for patients at low risk and more frequent screening for patients at higher risk, leading to decreased cost without delaying the diagnosis of clinically significant disease.

 

2 – Report: Building the foundations for sustainable development: a case for global investment in the capabilities of adolescents – The Lancet (free)

See also: Securing investments to realise the social and economic rights of adolescents (free) Our Future – Invest in Adolescent Health Now (free) AND Our future: a Lancet commission on adolescent health and wellbeing (all articles are free)

“Investing in adolescent health & education could bring 10-fold economic benefit” (RT @TheLancet see Tweet)

 

3 – Beyond Medication Reconciliation: The Correct Medication List – JAMA (free) (RT @AnilMakam see Tweet)

Achieving a “correct medication list” involves multiple levels of medication reconciliation. This viewpoint describes the main steps for achieving this goal.

 

4 – Association between active commuting and incident cardiovascular disease, cancer, and mortality: prospective cohort study – The BMJ (free)

Editorial: Active commuting is beneficial for health (free)

See also: Cycling to work can cut cancer and heart disease, says study – BBC News (free) AND Cycling to work: major new study suggests health benefits are staggering – The Conversation (free)

 

5 – Electronic Health Record Logs Indicate That Physicians Split Time Evenly Between Seeing Patients And Desktop Medicine – Health Affairs (link to abstract – $ for full-text)

Source: By the Numbers: Docs’ Logged-On Time Increases – MedPage Today (free registration required)

Related: Putting Patients First by Reducing Administrative Tasks in Health Care: A Position Paper of the American College of Physicians (free)

“Electronic health records systems now account for about half of the average doctor’s day”

 

6 – Why the Menace of Mosquitoes Will Only Get Worse – The New York Times Magazine (RT @CIDRAP  and @marynmck see Tweet) (10 articles per month are free)

Related: Disease Burden Growing as Vector Insects Adapt to Climate Change – IPS (free) (source Global Health NOW Newsletter) AND UN Doc: Climate Change is New Challenge in Fighting Disease Outbreaks – MedPage Today (free registration required)

“Climate change is altering the environment in ways that increase the potential for viruses like Zika”.

 

7 – The Lancet Countdown: Tracking Progress on Health and Climate Change – The Lancet (free)

Editorial: Climate and health: joining up the pieces, scaling up the action (free)

 

8 – Diabetes incidence and glucose intolerance prevalence increase with higher outdoor temperature – BMJ Open Diabetes Research & Care (free)

Sources: Climate Change Linked to Rising Diabetes Prevalence: Study – MedPage Today (free registration required) AND Is there a link between climate change and diabetes? – CNN (free)

“Association between climate change and diabetes?” (RT @kamleshkhunti see Tweet)

 

9 – Medical Alert! Climate Change Is Harming Our Health – Medical Society Consortium on Climate & Health (link to summary – free PDF available)

Sources: Medical Societies Come Together on Harms of Climate Change – Medscape (free registration required) AND Climate Change Already Affecting Human Health – Physician’s First Watch (free)

 

10 – Too many studies have hidden conflicts of interest. A new tool makes it easier to see them – VOX (free)

“Great news: PubMed is finally publishing info about funding sources/conflicts of interest on its abstracts” (RT @paimadhu and @juliaoftoronto see Tweet)

 

Wed, Apr 19 – Top 10 Medical News Stories!

19Apr
2017

 

1 – Integrating neglected tropical diseases in global health and development: Fourth WHO report on neglected tropical diseases (free)

Press release: Unprecedented progress against neglected tropical diseases, WHO reports (free)

See also: Executive summary (free) AND Neglected No More – Gates Notes (free) AND The world’s assault on tropical diseases is working – STAT News (free)

 

2 – A guide to neglected tropical diseases prioritised by the World Health Organisation – Financial Times (free) (RT @NTDCOUNTDOWN See Tweet)

See also: Fact sheets relating to NTD – World Health Organization (free)

“The World Health Organisation has selected 18 as good candidates to be controlled”

 

3 – Rapid Rule-out of Acute Myocardial Infarction with a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

See also: High-Sensitivity Troponin T Test Rules Out AMI in ED – Medscape (free registration required) AND Meta-Analysis: Single Cardiac Troponin Test Plus ECG Can Quickly Rule Out MI – Physician’s First Watch (free)

“This analysis indicates that a nonischemic ECG and a single negative High-Sensitivity Cardiac Troponin T only misses about 1 in 100 myocardial infarctions – and can provide rapid, useful information in an assessment.” (from Physician’s First Watch commentary above).

 

4 – Comparison of Recommended Eligibility for Primary Prevention Statin Therapy Based on the US Preventive Services Task Force Recommendations vs the ACC/AHA Guidelines – JAMA (link to abstract – $ for full-text)

See also: ACC/AHA vs. USPSTF statin guidelines – Cardiology News (free)

Although recommended by most guidelines for individuals at high risk, there is still some controversy over prescribing statins for primary prevention and over what patients benefit the most – see related commentary: Cholesterol-lowering statin therapy for healthy people is not as simple as ‘yes’ or ‘no’ – The Pharmaceutical Journal (free)

Adherence to the 2016 USPSTF recommendations for statin therapy, compared with the 2013 ACC/AHA guidelines, could lead to a lower number of individuals (an estimated difference of 9.3 million individuals in the U.S. population) recommended for primary prevention statin therapy.

 

5 – Associations of Maternal Antidepressant Use During the First Trimester of Pregnancy With Preterm Birth, Small for Gestational Age, Autism Spectrum Disorder, and Attention-Deficit/Hyperactivity Disorder in Offspring – JAMA (link to abstract – $ for full-text)

Contradicting a previous study showing increased risk of autism with antidepressant use during pregnancy (free), this large retrospect cohort study of 1 580 629 Swedish offspring did not show an association of antidepressant use during pregnancy and autism or other neurodevelopment problems.

 

6 – Dexamethasone versus standard treatment for postoperative nausea and vomiting in gastrointestinal surgery: randomised controlled trial (DREAMS Trial) – The BMJ (free)

A single dose of 8 mg intravenous dexamethasone at induction of anesthesia reduced postoperative nausea and vomiting with no increase in adverse events.

 

7 – Maternal asthma: Management strategies – Cleveland Clinic Journal of Medicine (free)

 

8 – Why it’s a bad idea to space out your child’s vaccination shots – The Washington Post (a few articles per month are free)

“Splitting immunizations into several visits only increases children’s stress” (RT @IDSAInfo see Tweet)

 

9 – The 2017 Atlas of Sustainable Development Goals: a new visual guide to data and development – The World Bank (free) (RT @glassmanamanda and @St_Klingebiel see Tweet)

With over 150 maps and data visualizations, the new publication charts the progress societies are making towards the United Nations 17 Sustainable Development Goals.

 

10 – Preventing Sports Injury and Illness: Key Resources for Family Physicians – American Family Physician (free)

Selection of resources for primary care providers to improve their ability to prevent and treat injuries from sports and physical activity.

 

Thu, Apr 20 – Top 10 Medical News Stories!

20Apr
2017

 

1 – Changes in prices, sales, consumer spending, and beverage consumption one year after a tax on sugar-sweetened beverages in Berkeley, California, US: A before-and-after study – PLOS One (free)

Sources: First US sugar tax sees soft drink sales fall by almost 10%, study shows – The Guardian (free) (RT @kamleshkhunti see Tweet) AND Sugary Drink Sales Fizzled After Soda Tax – MedPage Today (free registration required)

Related articles and commentaries on the possible benefits of sugar taxes: W.H.O. Urges Tax on Sugary Drinks to Fight Obesity – The New York Times (10 articles per month are free) Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND Mexico’s sugar tax leads to fall in consumption for second year running – The Guardian (free) AND Why the government should tax unhealthy foods and subsidise nutritious ones – The Conversation (free)

 

2 – Updated Guideline: Alcohol-use disorders: diagnosis and management of physical complications – National Institute for Health and Care Excellence (NICE – UK) (free)

 

3 – Updated Guideline: Irritable bowel syndrome in adults: diagnosis and management – National Institute for Health and Care Excellence (NICE – UK) (free)

 

4 – Cost-effectiveness of Common Diagnostic Approaches for Evaluation of Asymptomatic Microscopic Hematuria – JAMA Internal Medicine (free)

Invited commentary: Asymptomatic Microscopic Hematuria – Rethinking the Diagnostic Algorithm (free)

Routine urinalysis for screening is not presently recommended by any major health organization, but asymptomatic microscopic hematuria is a common incidental finding. This study suggests that the combination of renal ultrasound and cystoscopy is the most cost-effective approach for the evaluation of these patients.

 

5 – β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies – JAMA Internal Medicine (link to abstract – $ for full-text)

See also: No Fetal Heart Risk from Mom’s Beta-Blocker Use – MedPage Today (free registration required)

 

6 – Syncope and Its Impact on Occupational Accidents and Employment: A Danish Nationwide Retrospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (free)

News release: Fainting spells may increase risk of workplace accidents, job loss – American Heart Association News (free)

See also: 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (free PDF) AND First fainting guidelines issued to diagnose life-threatening heart conditions – American Heart Association News (free)

 

7 – Australasian Society for Infectious Diseases: low value interventions – The Medical Journal of Australia (free) (RT @ChooseWiselyAU and @ASIDANZ see Tweet)

See also: Choosing Wisely initiative was launched 5 years ago in our April 5 issue.

The society has just released a selection of 5 low value interventions (details in the text):

 

– Prescribing antibiotics for asymptomatic bacteriuria.

– Taking a swab of a leg ulcer without signs of clinical infection and treating the patient with antibiotics against the identified bacteria.

– Treating upper respiratory tract infections with antibiotics.

– Investigation for fecal pathogens in the absence of diarrhea or other gastrointestinal symptoms.

– Ordering multiple serological investigations for patients with fatigue without a clinical indication or relevant epidemiology.

 

8 – Use of Medications of Questionable Benefit at the End of Life in Nursing Home Residents with Advanced Dementia – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

See also: Use of Medications of Questionable Benefit at the End of Life in Nursing Home Residents with Advanced Dementia – CBCNews (free) AND Many With Advanced Dementia Receiving Drugs of Uncertain Benefit – Medscape (free registration required)

“Too much use of meds of questionable benefit at the end of life: Just Stop.” (RT @DeeMangin see Tweet)

 

9 – Should You Take an Anticoagulant for AF? — Applying the 4 questions – Dr John M Blog (free) (@drjohnm see Tweet)

See also: anticoagulation for atrial fibrillation decision aid endorsed by NICE – National Institute for Health Care Excellence (UK) (free)

Very interesting post about how to practice shared decision making in patients with atrial fibrillation.

 

10 – Mortality Trends After a Voluntary Checklist-based Surgical Safety Collaborative – Annals of Surgery (link to abstract – free PDF available)

Sources: Global Health NOW Newsletter (free) AND South Carolina Hospitals Saw Surgery Deaths Drop After Implementing WHO Checklist – AJMC News (free) AND A simple checklist prevents deaths after surgery, a large new study suggests – The Washington Post (a few articles per month are free)

See also: WHO Surgical Safety Checklist – World Health Organization (free) AND A Surgical Safety Checklist to Reduce Morbidity and Mortality in a Global Population – New England Journal of Medicine (free)

 

Tue, Apr 18 – Top 10 Medical News Stories!

18Apr
2017

 

1 – WHO Approves World’s First-Ever Dengue Vaccine – TIME (free) (RT @Onisillos and @JoanneLiu_MSF)

“For general background take a look at The Lancet Infectious Diseases Dengue series” (all articles are free) (RT @Onisillos see Tweet) 1 – Disease and economic burdens of dengue; 2 – Prevention and control of dengue – the light at the end of the tunnel; and 3 – Dengue: knowledge gaps, unmet needs, and research priorities

“World Health Organization Approves Dengue Vaccine: still lots of challenges ahead: it needs three injections & price” (RT @JoanneLiu_MSF see Tweet)

 

2 – Changes in the Employment Status and Risk of Stroke and Stroke Types – Stroke (Free PDF)

News release: Japanese study: Unemployment may increase stroke risk – American Heart Association News

Source: STAT Newsletter

 

3 – Non-Small Cell Lung Cancer – NCCN Clinical Practice Guidelines in Oncology (free)

 

4 – New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

Source: Critical Care Reviews Newsletter

 

5 – The Cost of Not Taking Your Medicine – The New York Times (10 articles per month are free)

According to the commentary, the lack of adherence to prescribed medications is estimated to cause approximately 125.000 deaths, at least 10 percent of hospitalizations and cost the American health care system between $100 billion and $289 billion a year.

 

6 – Too Clean for Our Children’s Good? – The New York Times (10 articles per month are free)

According to the “hygiene hypothesis”, some exposure to germs and microorganisms might be good for us because it helps develop the immune system. 

 

7 – The Breastfeeding-Friendly Pediatric Office Practice – American Academy of Pediatrics (free)

Source: AAP: Pediatricians Should Support Breastfeeding Moms – MedPage Today (free registration required)

Recent recommendation from another organization: Breastfeeding: Primary Care Interventions – U.S. Preventive Services Task Force (free)

Summary of USPSTF recommendations: Primary Care Interventions to Support Breastfeeding: Recommendation Statement – American Family Physician (free)

The American Academy of Pediatrics and the U.S. Preventive Services Task Force have issued recommendations for promoting and supporting breastfeeding.

 

8 – Association Between Hospitals’ Engagement in Value-Based Reforms and Readmission Reduction in the Hospital Readmission Reduction Program – JAMA Internal Medicine (link to abstract – $ for full-text)

Sources: Value-Based Reforms Linked to Readmission Reductions – Medscape (free registration required) AND Richard Lehman’s weekly review (free – see below)

A program of incentives (Medicare Hospital Readmission Reduction Program in the US) was effective in reducing 30 day readmissions following infarction, heart failure, and pneumonia.

 

9 – Richard Lehman’s weekly review of medical journals, 17 April 2017 – The BMJ Blogs (free)

 

10 – Relative effectiveness of insulin pump treatment over multiple daily injections and structured education during flexible intensive insulin treatment for type 1 diabetes: cluster randomised trial (REPOSE) – The BMJ (free)

See also: Insulin pump didn’t improve glycemic control compared to training on injections – ACP Diabetes Monthly (free)

 

Mon, Apr 17 – Top 10 Medical News Stories!

17Apr
2017

 

1 – Hospital costs in relation to body-mass index in 1.1 million women in England: a prospective cohort study – The Lancet (free)

Related commentary: The costs of overweight – The Lancet (free)

“Every 2 kg/m2 increase in BMI associated with a 7.4% increase in annual hospital costs” (RT @ZaherToumi see Tweet)

 

2 – Can machine-learning improve cardiovascular risk prediction using routine clinical data? – PLOS One (free)

See also: Self-taught artificial intelligence beats doctors at predicting heart attacks – Science (free)

“When expert MD guidelines are outperformed by machine learning for heart risk prediction” (RT @EricTopol see Tweet)

 

3 – A New, More Rigorous Study Confirms: The More You Use Facebook, the Worse You Feel – Harvard Business Review (free) (RT @EricTopol see Tweet)

Original article abstract ($ for full-text): Association of Facebook Use With Compromised Well-Being: A Longitudinal Study – American Journal of Epidemiology

 

4 – Amsterdam’s solution to the obesity crisis: no fruit juice and enough sleep – The Guardian (free) (RT @DrAseemMalhotra see Tweet)

“The city is successfully fighting fat by promoting tap water in its schools, along with healthy cooking classes and a ban on fast food sponsorship”

 

5 – The Ebola outbreak, 2013–2016: old lessons for new epidemics – Philosophical Transactions of the Royal Society B (free) (RT @royalsociety see Tweet)

This article is part of the themed issue ‘The 2013–2016 West African Ebola epidemic: data, decision-making and disease control’ (all articles are free)

Comprehensive review of the latest Ebola outbreak with lessons learned and recommendations for future epidemics.

 

6 – Integrating Clinical Research into Epidemic Response: The Ebola Experience (2017) – National Academies of Sciences, Engineering, and Medicine (Free Download – PDF)

Source: New report charts ways to expedite critical research during epidemics – STAT News (free)

 

7 – Yellow Fever – Once Again on the Radar Screen in the Americas – New England Journal of Medicine (free)

See also: Is Yellow Fever Knocking At Our Door? – NPR (free) AND ‘We didn’t expect this’: A historic yellow fever outbreak spreads in Brazil – STAT News (free)

 

8 – CSH (Chinese Society of Hepatology) guidelines for the diagnosis and treatment of drug-induced liver injury (free)

 

9 – Life after breast, prostate, and colon cancer: Primary care’s role – Cleveland Clinic Journal of Medicine (free)

 

10 – Diagnosis and management of psoriasis – Canadian Family Physician (free)

 

Fri, Apr 14 – 10 Medical Stories of The Day!

14Apr
2017

 

1 – Mortality and Cardiovascular Disease in Type 1 and Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Mortality and Cardiovascular Disease in Diabetes (free)

Large cohort showing the long-term cardiovascular outcomes in patients with diabetes.

 

2 – Ten years in public health 2007-2017 – World Health Organization (free)

WHO has launched a report that chronicles the evolution of global public health over the last decade. The first chapter examines WHO’s key role in promoting universal health coverage (free). The full series will be published over the next 6 weeks.

 

3 – Radical increase in water and sanitation investment required to meet development targets – World Health Organization (free)

See also: WHO’s work on water, sanitation and hygiene (free) AND WHO’s work on public health, environment and social determinants of health (free)

 

4 – Screening for Endocrine Hypertension: An Endocrine Society Scientific Statement (free)

Source: Screen for Endocrine Hypertension, Endocrine Society Says – Medscape (free registration required)

“The statement provides guidance on screening for 15 hormonal disorders that present with hypertension and that can be potentially cured with surgery or treated with medication” (from Medscape commentary above).

 

5 – European Association of Urology releases its 1st thromboprophylaxis guideline (free)

 

6 – Procedure-specific Risks of Thrombosis and Bleeding in Urological Cancer Surgery: Systematic Review and Meta-analysis – European Urology (free)

“Extended thromboprophylaxis is warranted in some procedures (eg, open and robotic cystectomy) but not others (eg, robotic prostatectomy without pelvic lymph node dissection in low-risk patients)

 

7 – Procedure-specific Risks of Thrombosis and Bleeding in Urological Non-cancer Surgery: Systematic Review and Meta-analysis – European Urology (free)

“Extended prophylaxis is warranted for some procedures (eg, kidney transplantation procedures in high-risk patients) but not others (transurethral resection of the prostate and reconstructive female pelvic surgery in low-risk patients)”

 

8 – Four reasons why we shouldn’t forget about Zika – The Conversation (free)

 

9 – Recorded childhood cancers rise by 13% worldwide, study finds – The Guardian (free)

Original articles: International incidence of childhood cancer, 2001–10: a population-based registry study – The Lancet Oncology (free) AND Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries – The Lancet Haematology (free) Related commentary: Issues raised by the incidence and survival of childhood cancers (free)

 

10 – ASCO has just published 3 guidelines on the management of pancreatic cancer:

1 – Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (free) AND 2 – Metastatic Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Summary (free) AND 3 – Locally Advanced Unresectable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Summary (free)

 

Thu, Apr 13 – 10 Medical Stories of The Day!

13Apr
2017

 

1 – Hospital Admissions for Myocardial Infarction and Stroke Before and After the Trans-Fatty Acid Restrictions in New York – JAMA Cardiology (link to abstract – $ for full-text)

Sources: Banning trans fats in New York prevented thousands of heart attacks, study finds – STAT News (free) AND Trans Fat Bans Tied to Fewer Heart Attacks and Strokes – The New York Times (10 articles per month are free)

Other localities might consider doing the same as well.

 

2 – Short term use of oral corticosteroids and related harms among adults in the United States: population based cohort study – The BMJ (free)

Corticosteroids, even if used for short periods of time, seems to be associated with significant morbidity and mortality. In this retrospective cohort with 1.5 million adults, the incidence of acute adverse events (sepsis, venous thromboembolism, fracture) increased by twofold to fivefold above background rates.

 

3 – Prostate Cancer Screening – Conflicting views on the new USPSTF draft recommendations

In favor of screening: New Official Prostate Cancer Screening Guidelines Announced: Too Little, Too Late? – Forbes (free) AND Federal Task Force Softens Opposition To Routine Prostate Cancer Screening – NPR

Against screening: The new recommendations for prostate cancer screenings are a bad deal – STAT News (free)

See also: Original USPSTF draft recommendations and related commentaries in yesterday’s issue

 

4 – Childhood cancers: 2 new studies on international incidence and survival (RT @TheLancet see Tweet)

Childhood cancer: International incidence of childhood cancer, 2001–10: a population-based registry study – The Lancet Oncology (free)

Childhood leukemia: Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries – The Lancet Haematology (free)

Related commentary: Issues raised by the incidence and survival of childhood cancers (free)

 

5 – Screening to Prevent Invasive Cervical Cancer: ASCO Resource-Stratified Clinical Practice Guideline (free)

“The ASCO guidelines outline the minimum standards for HPV-based screening for each resource strata; additional and more frequent screening may be added as the resources become available”.

 

6 – Potentially Curable Pancreatic Cancer: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

Due to a recent study showing a 2,5 month increase in median overall survival, the doublet regimen of gemcitabine and capecitabine seems to be preferred in the absence of concerns for toxicity or tolerance.

 

7 – The Patients Were Saved. That’s Why the Families Are Suing – The New York Times (free)

“Historically, the practice has been “if in doubt, err on the side of aggressive, life-sustaining treatment,””. That might be changing.

 

8 – Famine now threatens 20 million people – more than at any time since World War II – Washington Post (RT @AthaliaChristie and @wpjenna)

 

9 – Why Chinese Scientists Are More Worried Than Ever About Bird Flu – NPR Goats and Soda

Source: Global Health NOW Newsletter

H7N9 is a very deadly virus, killing around a third of the people who have contracted it. The virus has proved an ability to mutate quickly and researchers are concerned that a future mutation could make them to spread more easily among humans.

 

10 – Fresh fruit consumption in relation to incident diabetes and diabetic vascular complications: A 7-y prospective study of 0.5 million Chinese adults – PLOS Medicine (free)

Source: Fresh Fruit Protects Against Diabetes, Complications – MedPage Today (free registration required)

 

Tue, Apr 11 – 10 Medical Stories of The Day!

11Apr
2017

 

1 – Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study – BMC Medicine (free) (RT @atscommunity)

Cardioselective beta-blockers, mostly atenolol and bisoprolol in this cohort, were not associated with increased risk of moderate or severe asthma exacerbations. In contrast, non-selective beta-blockers, mostly sotalol and carvedilol in this cohort, were associated with increased risk.

 

2 – Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

“Labs performing these tests are reporting perfectly normal levels of vitamin D — 20 to 30 nanograms per milliliter of blood — as “insufficient.” As a consequence, millions of healthy people think they have a deficiency”

Note: Some organizations still think appropriate levels would be above 30 nanograms per milliliter of blood, more details in the text.

 

3 – Updated Fact Sheet: Lymphatic filariasis – World Health Organization (free) (RT @AbraarKaran)

See also: The Unexpected Cause Of This Awful Disease Lay Right Underfoot – NPR Health News (free) AND WHO’s Work on Neglected Tropical Diseases (free)

 

4 – Body-Weight Fluctuations and Outcomes in Coronary Disease – New England Journal of Medicine (link to abstract – $ required for full-text)

Source: Weight Fluctuation Tied to Mortality in CAD Population – MedPage Today (free registration required)

 

5 – Emergencies in Hematology and Oncology – Mayo Clinic Proceedings (free)

Comprehensive review covering the most common oncological emergencies.

 

6 – Pharmacological treatment optimization for stable chronic obstructive pulmonary disease. Proposals from the Société de Pneumologie de Langue Française (free)

 

7 – Risk of pneumonia associated with incident benzodiazepine use among community-dwelling adults with Alzheimer disease – CMAJ (free)

Source: Benzodiazepines Tied to Higher Pneumonia Risk in Patients with Alzheimer’s – Physician’s First Watch (free)

 

8 – Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials – The Lancet (link to abstract – $ required for full-text) (RT @AnilMakam “Lower achieved blood pressure in high risk patients for cardiovascular disease do WORSE” see Tweets)

In high-risk patients, patients who achieved a systolic blood pressure < 120 mmHg or a diastolic blood pressure < 70 mmHg had HIGHER risk of complications. “These data suggest that the lowest blood pressure possible is not necessarily the optimal target for high-risk patients”

 

9 – Richard Lehman’s weekly review of medical journals – The BMJ Blogs (free)

 

10 – Toward Responsible Human Genome Editing – JAMA (free)

 

Wed, Apr 12 – 10 Medical Stories of The Day!

12Apr
2017

 

1 – Prostate Cancer Screening Draft Recommendations – U.S. Preventive Services Task Force (free)

Viewpoint: The US Preventive Services Task Force 2017 Draft Recommendation Statement on Screening for Prostate Cancer: An Invitation to Review and Comment – JAMA (free)

See also: Should you get screened for prostate cancer? We break down the latest advice – STAT News (free)

For those aged 55 to 69 it recommends “informed, individualized decision making based on a man’s values and preferences”. According to a useful infographic from the draft recommendations, the benefits are likely small. For every 1000 men offered PSA based screening over a period of 10-15 years, the test would avoid cancer spreading in 3 men and death from prostate cancer in 1-2 men, with the undesired consequences of false positives and subsequent procedures in many patients.

 

2 – Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free)

Related commentary: Tallying the bills of mortality from air pollution (free)

4.2 million deaths globally were attributable to fine particles and another 254 000 to surface ozone in 2015. The article also has details on country-specific deaths and disability-adjusted life-years from 1990 through 2015.

 

3 – How Many Pills Are Too Many? – The New York Times (10 articles per month are free)

“Evidence has mounted about the dangers of taking multiple, perhaps unnecessary, medications” (from Tweet)

 

4 – The hospital of tomorrow in 10 points – Critical Care (free)

This is the first article in a new thematic series about the future of critical care (free)

 

5 – EULAR revised recommendations for the management of fibromyalgia – Annals of Rheumatic Diseases (free)

Source: EULAR Revised Recommendations for the Management of Fibromyalgia – Medscape (free registration required)

 

6 – Management of Osteoarthritis of the Hip – American Academy of Orthopedic Surgeons (free PDF)

Source: AAOS releases new clinical practice guideline for osteoarthritis of the hip – Medical Express (free)

 

7 – New ILAE Epilepsy Classification Published – Medscape (free registration required)

Position paper: Operational classification of seizure types by the International League Against Epilepsy (free)

Practical manual: Instruction manual for the ILAE 2017 operational classification of seizure types (free)

“For the first time in 30 years, an epileptic seizures classification update” (RT @MedscapeNeuro see Tweet)

 

8 – Vitamins and the Failure of Free-Market Health – The Atlantic (free)

“The booming dietary-supplement industry is plagued by outlandish claims, undermining credible science, and seeding confusion”.

 

9 – Effect of Baseline Nutritional Status on Long-term Multivitamin Use and Cardiovascular Disease Risk – JAMA Cardiology (link to abstract – $ required for full-text)

See also: Multivitamins may not improve heart health in men – UPI (free) AND Other recent commentary on multivitamins: Multivitamins a waste of money and just create ‘very expensive urine’ – The Guardian (free)

“Multivitamin use does not prevent major CV disease events in men, regardless of baseline nutritional status” (RT @CaulfieldTim)

 

10 – Surprising And Sobering: 7 Facts About Global Health – NPR (free)

 

Mon, Apr 10 – Top 10 Medical News Stories

10Apr
2017

 

Links = Interest ≠ Endorsement

 

1 – Hypertension Canada’s 2017 Guidelines for Diagnosis, Risk Assessment, Prevention, and Treatment of Hypertension in Adults (free)

 

2 – Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients – New England Journal of Medicine (link to abstract – $ required for full text)

Quick Take Video Summary: SURTAVI Study: TAVR versus Open Surgery (free)

See this and other highlights from the American College of Cardiology’s 66th Annual Scientific Session (some articles are no longer free)

This innovative technology seems to be useful for patients with aortic stenosis at high risk for surgery. In this new study, it was noninferior to surgery at 2 years of follow-up in old patients (averaged nearly 80 years) at intermediate risk. Longer follow up data will be important to see if it is a suitable alternative for younger patients.

 

3 – The cross-cutting contribution of the end of neglected tropical diseases to the sustainable development goals – Infectious Diseases of Poverty (free) (RT @ghn_news see Tweet)

Related commentary from the author: Impact beyond the neglected (free)

See also: United Nations – Sustainable Development Goals

This review examines how the interventions being used against neglected tropical diseases are contributing to achieving the United Nation’s Sustainable Development Goals.

 

4 – The World Health Organization Adult Attention-Deficit/Hyperactivity Disorder Self-Report Screening Scale for DSM-5 – JAMA Psychiatry (free)

Invited commentary: Good News for Screening for Adult Attention-Deficit/Hyperactivity Disorder – JAMA Psychiatry (free)

See also: Do You Zone Out? Procrastinate? Might Be Adult ADHD – NPR Health News (free)

Others disagree… call it “disease mongering”, “overdiagnosis”. For example, Prof Allen Francis, author of Saving Normal: An Insider’s Revolt against Out-of-Control Psychiatric Diagnosis, DSM-5, Big Pharma, and the Medicalization of Ordinary Life, wrote some remarks about the study, see Tweet 1, Tweet 2 and Tweet 3

See also: The Selling of Attention Deficit Disorder – The New York Times (10 articles per month are free)

 

5 – F.D.A. Will Allow 23andMe to Sell Genetic Tests for Disease Risk to Consumers – The New York Times (10 articles per month are free)

See also: Before you send your spit to 23andMe, what you need to know – STAT News (free) AND 23andMe given green light to sell DNA tests for 10 diseases – Nature News (free) AND 23andMe Rides Again: FDA Clears Genetic Tests To Predict Disease Risk – Forbes (free) AND Too Much Information? FDA Clears 23AndMe to Sell Home Genetic Tests for Alzheimer’s and Parkinson’s – Scientific American (free)

“The controversial step will significantly expand direct-to-consumer testing – but what if the news is bad?” (from Scientific American above)

 

6 – TV. How much is too much for our kids? – World Economic Forum (free)

Original Article Abstract ($ required for full-text): Family Socioeconomic Status Moderates Associations Between Television Viewing and School Readiness Skills – Journal of developmental and behavioral pediatrics

See also: Media and Young Minds – Recommendations from The American Academy of Pediatrics (free) AND Pediatricians relax guidelines on screen time for kids to give more flexibility – STAT News (free)

 

7 – No TV during meals may lower obesity risk – Medical News Today (free)

Original article abstract ($ required for full-text): Television, Home-Cooked Meals, and Family Meal Frequency: Associations with Adult Obesity – Journal of the Academy of Nutrition and Dietetics

Related article: Screen time is associated with adiposity and insulin resistance in children – Archives of Diseases in Childhood (free) AND Screentime linked to greater diabetes risk among children – The Guardian (free)

The first study in adults and the second study in children suggest there might be a link between screen time and weight gain or adiposity.

 

8 – Here’s why one tech investor thinks some doctors will be ‘obsolete’ in five years – CNBC (free) (RT @CMichaelGibson)

According to this point of view, radiologists will be the first ones that are affected by Artificial Intelligence. As we can see below, other specialists that work by interpreting medical images may follow, like dermatologists, ophthalmologists and pathologists.

See also: If You Look at X-Rays or Moles for a Living, AI Is Coming for Your Job – Wired (free) AND Adapting to Artificial Intelligence: Radiologists and Pathologists as Information Specialists – JAMA Viewpoint (free – and legal – PDF found with Unpaywall) AND Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs – JAMA Internal Medicine (link to abstract – $ required for full-text) AND Predicting non-small cell lung cancer prognosis by fully automated microscopic pathology image features – Nature (free) see commentary in Computers trounce pathologists in predicting lung cancer type, severity, researchers find – Science News (free)

 

9 – When Globalization Brings Brain-Invading Worms – The Atlantic (free) (RT @PreetiNMalani and @AdrienneLaF)

Infectious diseases are spreading faster and emerging quicker due to globalization.

 

10 – Seniors are given so many drugs, it’s madness – The Globe and Mail (free) (RT @RasoiniR)

“While most prescribing is well-intentioned, it’s also unco-ordinated; there is a tendency to overmedicate and leave people on drugs for too long”.

 

Thu, Apr 6 – 10 Medical Stories of The Day!

6Apr
2017

 

1 – The first issue of the Lancet Planetary Health is out (#OpenAccess)

Editorial: Welcome to The Lancet Planetary Health

 

2 – Unpaywall finds free versions of paywalled papers – Nature (free) (RT @dannykay68)

See also: Unlocking paywalled research papers: Two big steps forward, two steps back, by James C Coyne – Coyne of the Realm (RT @hildabast)

Apparently, it successfully finds an open-access version (completely legal) of a paper around 30% of the time. We have tried and it worked for some of the articles we’ve tested. See it for yourself.

 

3 – Long-term use of antibiotics and risk of colorectal adenoma – Gut (free)

Sources: Antibiotics overuse could increase bowel cancer risk, study finds – The Guardian (free) (RT @Onisillos) AND Long-Term Use of Antibiotics Associated with Later-Life Colorectal Adenomas – Physician’s First Watch (free)

 

4 – Effectiveness of Vaccination During Pregnancy to Prevent Infant Pertussis – Pediatrics (free)

See also: Study: Pertussis shot in pregnant moms protects newborns – CIDRAP (free)

Source: Global Health NOW Newsletter

 

5 – Inhaled Corticosteroids May Raise Women’s Risk of the Metabolic Syndrome – NewsWise (free)

See also: Inhaled Corticosteroid Use May Up Metabolic Syndrome Risk – MPR (free)

This study was presented at #ENDO2017 and hasn’t been published yet.

 

6 – National Heart Foundation of Australia & Cardiac Society of Australia and New Zealand: Australian Clinical Guidelines for the Management of Acute Coronary Syndromes (free)

 

7 – Low-dose aspirin can reduce risk of death from cancer, research says – CNN (free)

Not so fast: CNN claims aspirin can reduce cancer death risk, falling into observational study trap – HealthNewsReviews (free)

See also: Final Recommendation Statement: Aspirin Use to Prevent Cardiovascular Disease and Colorectal Cancer – U.S. Preventive Services Task Force (free)

 

8 – Cancer patients have 55% greater risk of suicide, study finds – The Guardian (free) (RT @ghn_news)

 

9 – Antibiotic-Resistant ‘Superbugs’ Are Here – Council on Foreign Relations (free)

See also: Tackling Drug-Resistant Infections Globally: final report and recommendations (free)

Source: Global Health NOW Newsletter

 

10 – Managing supplies of vaccines is a huge problem – The Economist (free) (RT @glassmanamanda)

See also: Building Next Generation Immunization Supply Chains – Vaccine Supplement (free) AND Global Immunization Impact Constrained by Outdated Vaccine Delivery Systems, Researchers Say – World Health Organization (free)

 

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