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NEWS - TOP 10 Medical News Stories

 

1 – Manual: Preventing surgical site infections: implementation approaches for evidence-based recommendations – World Health Organization (free PDF) (via @onisillos)

 

2 – Recommendations on screening for breast cancer in women aged 40–74 years who are not at increased risk for breast cancer – Canadian Medical Association Journal (free)

Summary: Breast Cancer Update (2018) – Canadian Task Force on Preventive Health Care (free)

News Release: Breast cancer screening: New emphasis on shared decision-making between women and their doctors (free)

See Also: Infographics for Shared Decision-Making (free)

 

3 – The Association of Coloproctology of Great Britain and Ireland consensus guidelines in surgery for inflammatory bowel disease – Colorectal Disease (free)

 

4 – Clinical Impact of the Polypill for Cardiovascular Prevention in Latin America: A Consensus Statement of the Inter-American Society of Cardiology – Global Heart (free) (via @gonzaeperez)

 

5 – Comparative effectiveness and safety of interventions for acute diarrhea and gastroenteritis in children: A systematic review and network meta-analysis – PLOS One (free)

 

6 – Review: Management Options for Irritable Bowel Syndrome – Mayo Clinic Proceedings (free)

 

7 – What These Medical Journals Don’t Reveal: Top Doctors’ Ties to Industry – The New York Times (10 articles per month are free)

 

8 – Cochrane Special Collections: Diagnosing skin cancer (free articles)

News Release: Cochrane Library Special Collection: Diagnosing skin cancer (free)

 

9 – Patient safety after implementation of a coproduced family centered communication programme: multicenter before and after intervention study – The BMJ (free)

Commentaries: Ensure that the family’s voice is heard first and last, and in their own words – The BMJ Opinion (free) AND Improving patient safety? Ask the patient – The BMJ Opinion (free) AND A new way to curb harmful medical errors: talk more to patients and families – STAT (free)

 

10 – Ultrarestrictive Opioid Prescription Protocol for Pain Management After Gynecologic and Abdominal Surgery – JAMA Network Open (free)

Commentaries: Striving for Evidence-Based Postoperative Opioid Prescribing While Optimizing Perioperative Pain Management—Shifting to Conservative Prescribing – JAMA Network Open (free) AND Opioid Prescriptions Can Be Drastically Reduced After Surgery with No Increase in Pain, Study Shows – Roswell Park (free)

 


 

1 – Guideline: Chronic obstructive pulmonary disease (acute exacerbation): antimicrobial prescribing – National Institute for Health and Care Excellence (free)

Commentary: GPs should consider restricting antibiotics for COPD – OnMedica (free)

 

2 – Guideline: Chronic obstructive pulmonary disease in over 16s: diagnosis and management – National Institute for Health and Care Excellence (free)

 

3 – Guideline: Post-traumatic stress disorder – National Institute for Health and Care Excellence (free)

 

4 – Essential points from Evidence-based Clinical Practice Guidelines for Chronic Kidney Disease 2018 – Japanese Society of Nephrology (free)

 

5 – Quantifying the benefits and harms of various preventive health activities – Australian Journal of General Practice (free) (via @PaulGlasziou)

 

6 – Dr. Lisa Schwartz, Critic of Medical Excess, Is Dead at 55 – The New York Times (10 articles per month are free)

 

7 – Critical review of the evidence underlying management of glucocorticoid-induced hyperglycaemia – European Journal of Endocrinology (free)

 

8 – Prevalence of and Factors Associated With Patient Nondisclosure of Medically Relevant Information to Clinicians – JAMA Network Open (free)

Commentaries: Threats to the Validity of the Clinical Interview: Can Anything Be Done? – JAMA Network Open (free) AND Patients often withhold relevant information from doctors – Reuters (free) AND Most Patients Have Held Back the Truth From Doctors, JAMA Results Show – AJMC (free) AND Why patients lie to their doctors – University of Utah Health (free) AND Majority of Patients Withhold Important Information From Their Health Care Providers – MedicalResearch.com (free)

 

9 – The UCL–Lancet Commission on Migration and Health: the health of a world on the move (free articles – registration required)

Commentaries: Harmful myths about migration and health used to justify policies of exclusion are unfounded – London School of Hygiene & Tropical Medicine (free) AND Report: Facts About Migrants Don’t Always Match What The Headlines Say – NPR (free) AND Myths about migrants spreading disease ‘inform hostile policies’ – The Guardian (free)

 

10 – Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial – The Lancet (free)

Commentaries: Fluoxetine and recovery after stroke – The Lancet (free) AND Fluoxetine (Prozac) Did Not Reduce Risk of Depression After Stroke, But Did Raise Risk of Fractures – MedicalResearch.com (free) AND Common antidepressant does not aid stroke recovery, study finds – University of Edinburgh (free)

 


 

1 – 2018 ACC Expert Consensus Decision Pathway on Tobacco Cessation Treatment – Journal of the American College of Cardiology (free)

Summary: 2018 ACC Decision Pathway on Tobacco Cessation Treatment – American College of Cardiology (free)

 

2 – Anesthesia interventions that alter perioperative mortality: a scoping review – Systematic Review (free)

 

3 – Apixaban to Prevent Venous Thromboembolism in Patients with Cancer – New England Journal of Medicine (free)

Commentary: NOACs Significantly Curb Risk of VTE in Cancer Patients – TCTMD (free)

 

4 – 2018 recommendations for the management of community acquired pneumonia – Jornal Brasileiro de Pneumologia (free PDF)

Related Guideline: Pneumonia in adults: diagnosis and management – National Institute for Health and Care Excellence (free)

 

5 – Review: Assessment and initial management of acute undifferentiated fever in tropical and subtropical regions – The BMJ (free for a limited period)

 

6 – Review: Diaphragmatic dysfunction – Pulmonology (free)

 

7 – Review: Examination of the Patient with Dizziness or Imbalance – Medical Clinics of North America (free)

 

8 – Perspective: Risk-Reducing Mastectomy in BRCA1 and BRCA2 Mutation Carriers: A Complex Discussion – JAMA (free for a limited period)

 

9 – China backs bold plan to tear down journal paywalls – Nature (free)

Related: Europe’s Bold Open-Access Plan Detailed (free report and commentaries)

 

10 – Epigenetically reprogrammed methylation landscape drives the DNA self-assembly and serves as a universal cancer biomarker – Nature Communications (free)

Commentaries: One test to diagnose them all: researchers exploit cancers’ unique DNA signature – The Conversation (free) AND Nano-signature discovery could revolutionise cancer diagnosis – University of Queensland (free) AND ‘Universal fingerprint’ in cancer DNA points to potential blood test. But it’s not ready for patients – Cancer Research UK (free) AND Holy grail cancer test? Hold on. Here’s what you need to know – HealthNewsReview (free)

 


 

1 – Systematic Review: What are the most common conditions in primary care? – Canadian Family Physician (free)

 

2 – Perspective: Whole-Fat or Nonfat Dairy? The Debate Continues – JAMA (free for a limited period)

 

3 – Livebirth after uterus transplantation from a deceased donor in a recipient with uterine infertility – The Lancet (link to abstract – $ for full-text)

Commentaries: For the first time, a baby is born via a uterus transplant from a deceased donor – STAT (free) AND Mother gives birth with uterus from deceased donor – OnMedica (free) AND Expert reaction to first baby born by uterus transplant from a deceased donor – Science Media Centre (free) AND First baby born after deceased womb transplant – BBC (free)

 

4 – 2018 Korean Guideline of Atrial Fibrillation Management – Korean Circulatory Journal (free)

Related Guidelines: 2018 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation (free) AND 2016 ESC Guidelines for the management of atrial fibrillation developed in collaboration with EACTS (free)

 

5 – Nurse staffing, nursing assistants and hospital mortality: retrospective longitudinal cohort study – BMJ Quality & Safety (free)

Commentaries: Lack of nurses linked to increased risk of patient death – OnMedica (free) AND Low Nurse Staffing Increases Risk for Inpatient Death – Medscape (free registration required)

 

6 – Caring for the critically ill patients over 80: a narrative review – Annals  of Intensive Care (free)

 

7 – Cardiac Screening of Young Athletes: a Practical Approach to Sudden Cardiac Death Prevention – Current Treatment Options in Cardiovascular Medicine (free)

 

8 – Podcast: Delirium: Prevention, Diagnosis, and Treatment – JAMA (free)

 

9 – Association of estimated sleep duration and naps with mortality and cardiovascular events: a study of 116 632 people from 21 countries – European Heart Journal (free)

News Release: Too much or too little sleep linked to increased risk of cardiovascular disease and death – European Society of Cardiology (free)

Editorial: Sleep and cardiovascular risk: how much is too much of a good thing? (free)

 

10 – Association of Primary Care Consultation Patterns With Early Signs and Symptoms of Psychosis – JAMA Network Open (free)

Commentaries: Identifying Risk of Psychosis in a Primary Care Setting – JAMA Network Open (free) AND Spotting patients at risk for psychosis: 12 high-risk symptoms – Univadis (free registration required)

 


 

1 – Finding the Balance Between Benefits and Harms When Using Statins for Primary Prevention of Cardiovascular Disease: A Modeling Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Statins may be significantly overprescribed for primary prevention, computer model suggests – ACP Internist (free) AND Benefits of Statins Only Exceed Harms at Higher 10-Year Risk Thresholds, Study Suggests – TCTMD (free) AND Higher Risk Thresholds May Be Needed for Starting Statins for Primary CVD Prevention, Study Suggests – NEJM Journal Watch (free) AND Statins are being overprescribed, study suggests – OnMedica (free)

 

2 – The Ethics of Heritable Genome Editing: New Considerations in a Controversial Area – JAMA (free for a limited period)

Related: WHO looks at standards in ‘uncharted water’ of gene editing – Reuters (free) AND The CRISPR Baby Scandal Gets Worse by the Day – The Atlantic (free) AND We need a temporary moratorium on using gene editing to create babies – STAT (free) AND Is the CRISPR baby controversy the start of a terrifying new chapter in gene editing? – VOX (free) AND First CRISPR babies: six questions that remain – Nature (free) AND ‘I feel an obligation to be balanced.’ Noted biologist comes to defense of gene editing babies – Science (free)

 

3 – Fasting-Evoked En Route Hypoglycemia in Diabetes (FEEHD): An Overlooked Form of Hypoglycemia in Clinical Practice – International Journal of Endocrinology (free)

Commentary: Fasting for lab tests isn’t good for patients with diabetes – Michigan State University (free)

 

4 – Last Month in Oncology with Dr. Bishal Gyawali: November 2018 – eCancer News (free)

 

5 – Review: Confounders of severe asthma: diagnoses to consider when asthma symptoms persist despite optimal therapy – World Allergy Organization Journal (free)

 

6 – Perspective: Potential Risks and Benefits of Mental Health Screening of Physicians – JAMA (free for a limited period)

 

7 – Perspective: Why the world is becoming more allergic to food – BBC (free)

 

8 – Clinical validation of a risk scale for serious outcomes among patients with chronic obstructive pulmonary disease managed in the emergency department – Canadian Medical Association Journal (free)

News Release: Tool identifies which patients with COPD are at risk of death, serious complications (free)

Commentary: Tool quickly identifies risk for deadly COPD complications – UPI (free)

 

9 – Predictors of dementia misclassification when using brief cognitive assessments – Neurology (free PDF)

Commentary: Study Finds Biases in Widely Used Dementia Identification Tests – University of Exeter (free) AND Primary Care Tests Flunk for Classifying Dementia – MedPage Today (free registration required) AND Brief Cognitive Exams Commonly Misdiagnose Dementia – NEJM Journal Watch (free)

 

10 – Body-weight fluctuation and incident diabetes mellitus, cardiovascular disease, and mortality: a 16-year prospective cohort study – The Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)

Commentaries: Weight cycling is associated with a higher risk of death – The Endocrine Society (free) AND Study: Yo-yo diets can increase death risk – UPI (free)

 


 

1 – Why the HIV epidemic is not over – World Health Organization (free)

 

2 – Clinical Report: Selecting Appropriate Toys for Young Children in the Digital Era – American Academy of Pediatrics (free)

News Release: Best toys for children’s development? Hint: They are not electronic or costly – AAP News (free)

Commentaries: AAP Offer Toy Tips for Parents and Clinicians in the Digital Age – NEJM Journal Watch (free) AND Empty boxes top high-tech toys on doctor-recommended list – Associated Press (free)

 

3 – Perspective: Why Hospitals Should Let You Sleep – The New York Times (10 articles per month are free)

“Frequent disruptions are more than just annoying for patients. They can also cause harm.”

 

4 – Podcast: #128 Aspirin Overhyped and Overused – The Curbsiders Internal Medicine Podcast (free)

 

5 – Editorial: Focus on randomised clinical trials – Intensive Care Medicine (free PDF) (via @CritCareReviews)

Related: What should we stop doing in the ICU? – ICU Management & Practice (free)

Their results add to what appears to be a constant theme in critical care, ‘less is more’ based on RCT results”

 

6 – Alex Nowbar’s weekly research reviews, 3 December 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 

7 – Interpreting the Athlete’s ECG: Current State and Future Perspectives – Current Treatment Options in Cardiovascular Medicine (free)

 

8 – Economic and Quality-of-Life Outcomes of Natriuretic Peptide–Guided Therapy for Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Natriuretic peptide-guided therapy falls flat in improving HFrEF outcomes – Cardiovascular Business (free) AND Quality-of-Life Outcomes With Natriuretic Peptide-Guided Therapy for Heart Failure – Cardiology Advisor (free)

 

9 – Clinical practice guidelines for older people with multimorbidity and life-limiting illness: what are the implications for deprescribing? – Therapeutic Advances in Drug Safety (free)

 

10 – Impact of patient and public involvement on enrolment and retention in clinical trials: systematic review and meta-analysis – The BMJ (free)

Commentaries: Joanna Crocker: Time to embrace patient involvement in clinical trials? – The BMJ Opinion (free) AND “Researchers don’t know what they’re missing”—the impact of patient involvement in research – The BMJ Opinion (free) AND Impact of PPI in clinical trials – University of Oxford (free)

 


 

1 – Hydroxyurea for Children with Sickle Cell Anemia in Sub-Saharan Africa – New England Journal of Medicine (free)

Commentaries: Studies Show Improved Sickle Cell Disease Outcomes Worldwide – American Society of Hematology (free) AND ASH 2018: Large Single-Arm Trial of Hydroxyurea for Sickle Cell Anemia in Sub-Saharan Africa – The ASCO Post (free) AND Sickle cell anemia treatment safely lowers disease burden in African children – Cincinnati Children’s Hospital Medical Center (free) AND ‘From Nothing to Gangbusters’: A Treatment for Sickle-Cell Disease Proves Effective in Africa – New England Journal of Medicine (10 articles per month are free)

 

2 – 2018 American College of Rheumatology/National Psoriasis Foundation Guideline for the Treatment of Psoriatic Arthritis – Arthritis Care & Research (free)

 

3 – 2018 Global Nutrition Report (free)

Commentaries: 2018 Global Nutrition Report reveals malnutrition is unacceptably high and affects every country in the world, but there is also an unprecedented opportunity to end it – UNICEF (free) AND ‘Diabolical’ diets: four in 10 children consume sugary drinks daily – The Guardian (free) AND ‘No country is untouched’: Global Nutrition Report highlights compounding malnutrition – Devex (free)

 

4 – Global Atlas of Cardiovascular Disease 2000-2016: The Path to Prevention and Control – Global Heart (free)

 

5 – Medical Screening Tests You Do and Don’t Need – Consumer Reports (free) (via @EricTopol)

“Some may be life-saving, but others can waste time and money—and pose risks”

 

6 – Current opinions for the management of asthma associated with ear, nose and throat comorbidities – European Respiratory Review (free)

 

7 – Viewpoint: The Challenges of Improving Treatments for Depression – JAMA (free)

 

8 – Outdoor Artificial Nighttime Light and Use of Hypnotic Medications in Older Adults: A Population-Based Cohort Study – Journal of Clinical Sleep Medicine (free)

Commentary: Light pollution may cause insomnia in older adults – American Academy of Sleep Medicine (free)

 

9 – Unscrambling the relations of egg and meat consumption with type 2 diabetes risk – American Journal of Clinical Nutrition (free)

Commentary: LLU School of Public Health study finds meat, not eggs, is linked to type 2 diabetes – Loma Linda University School of Public Health (free)

Related Studies: Red meat consumption and risk of type 2 diabetes: 3 cohorts of US adults and an updated meta-analysis – American Journal of Clinical Nutrition (free) AND Changes in Red Meat Consumption and Subsequent Risk of Type 2 Diabetes Mellitus: Three Cohorts of US Men and Women – JAMA Internal Medicine (free)

 

10 – Associations of Smoke‐Free Policies in Restaurants, Bars, and Workplaces With Blood Pressure Changes in the CARDIA Study – Journal of the American Heart Association (free)

News Release: Smoke-free policies associated with lower blood pressure – American Heart Association (free)

Editorial: Necessity of Preventing Cardiovascular Disease by Smoke‐Free Policies (free)

Commentaries: Smoking bans tied to lower blood pressure in non-smokers – Reuters (free) AND Smoking bans in restaurants, workplaces linked to lower SBP – Cardiovascular Business (free)

Related Study: Updating the evidence relating smoking bans to incidence of heart disease – Regulatory Toxicology and Pharmacology (free)

 


 

1 – The 2018 report of the Lancet Countdown on health and climate change: shaping the health of nations for centuries to come – The Lancet (free registration required)

Editorial: Humanising health and climate change (free)

Commentaries: Global warming will increase heat-related death and disease – study – Reuters (free) AND Climate change and air pollution damaging health and causing millions of premature deaths – International Institute for Applied Systems Analysis (free) AND 5 ways climate change is bad for your health – Imperial College London (free)

Related: Projections of Temperature-Related Excess Mortality Under Climate Change Scenarios (free study and commentaries) AND Quantifying Excess Deaths Related to Heatwaves Under Climate Change Scenarios (free study and commentaries)

 

2 – Inpatient and Outpatient Infection as a Trigger of Cardiovascular Disease: The ARIC Study – Journal of the American Heart Association (free)

Editorial: Spark That Lights the Fire: Infection Triggers Cardiovascular Event (free)

Commentary: Infections may be a ‘trigger’ for heart attack, stroke – American Heart Association News (free)

 

3 – Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis – International Journal of Cardiology (free)

“…current fluoroquinolone use was significantly associated with increased risk of aortic aneurysm and dissection.”

 

4 – Progress Toward Regional Measles Elimination — Worldwide, 2000–2017 – Centers for Disease Control and Prevention (free)

Commentaries: Measles cases spike globally due to gaps in vaccination coverage – World Health Organization (free) AND Report: Measles spike triggered by vaccination gaps – CIDRAP (free) AND Measles cases surged globally in 2017 due to gaps in vaccine coverage, health agencies say – CNN (free)

 

5 – Cesarean delivery rate and staffing levels of the maternity unit – PLOS One (free)

Commentary: Staffing more doctors and midwives tied to lower C-section rates – Reuters (free)

 

6 – We’re Living Longer … But A Medical Journal Sees Many Causes For Alarm – NPR (free)

Related Editorial: GBD 2017: a fragile world – The Lancet (free)

 

7 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentaries: DRC’s 426-case Ebola outbreak now 2nd largest ever – CIDRAP (free) AND Ebola and War in the Democratic Republic of Congo: Avoiding Failure and Thinking Ahead – JAMA (free) AND Ramping Up the Response to Ebola – New England Journal of Medicine (free) AND Ebola outbreak in east Congo now world’s second biggest – Reuters (free)

 

8 – Potentially serious incidental findings on brain and body magnetic resonance imaging of apparently asymptomatic adults: systematic review and meta-analysis – The BMJ (free)

Commentary: Many incidental findings spotted on MRIs, few turn out to be cancer – Reuters (free)

Related: Prevalence and outcomes of incidental imaging findings: umbrella review (free)

 

9 – Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Low-Dose Imipramine Alternative Treatment for Refractory Functional Dyspepsia – Clinical Advisor (free)

 

10 – Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Cardiovascular Toxicities Associated With Immune Checkpoint Inhibitor Treatment – The ASCO Post (free)

Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 


 

1 – ASH Clinical Practice Guidelines on Venous Thromboembolism – American Society of Hematology (free)

News Release: New clinical practice guidelines for venous thromboembolism (free)

 

2 – Principles for Patient and Family Partnership in Care: An American College of Physicians Position Paper – Annals of Internal Medicine (free)

News Release: American College of Physicians releases principles to guide patient partnership in health care (free)

 

3 – A guideline for the diagnosis and management of polycythaemia vera. A British Society for Haematology Guideline (free)

 

4 – Attention Deficit–Hyperactivity Disorder and Month of School Enrollment – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: When starting school, younger children are more likely to be diagnosed with ADHD – Harvard Medical School (free) AND Youngest Children In A Class Are Most Likely To Get ADHD Diagnosis – NPR (free) AND Younger school entry could set stage for ADHD diagnosis – Associated Press (free)

Related: Systematic Review: Youngest in Class More Likely to be Diagnosed with ADHD (free study and commentaries)

 

5 – Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)

Video Summary: Alirocumab and CV Events after Acute Coronary Syndrome (free)

 

6 – Prolonged thromboprophylaxis with low molecular weight heparin for abdominal or pelvic surgery – Cochrane Library (free)

Summary: Do blood thinner injections given after abdominal surgery further reduce blood clots if continued after discharge from the hospital? – Cochrane Library (free)

 

7 – Plan S: From Principles to Implementation. cOAlition S Releases Implementation Guidance on Plan S (free)

Commentary: Funders flesh out details of Europe’s bold open-access plan (free)

Related: In Win for Open Access, Two Major Funders Won’t Cover Publishing in Hybrid Journals (free commentaries) AND cOAlition S: Making Open Access a Reality by 2020 (free Statement and commentaries)

 

8 – Is our constant use of digital technologies affecting our brain health? We asked 11 experts – VOX (free)

 

9 – WHO Housing and health guidelines – World Health Organization (free)

 

10 – Global, regional, and national estimates of pneumonia morbidity and mortality in children younger than 5 years between 2000 and 2015: a systematic analysis – The Lancet Global Health (free)

Invited Commentary: Global childhood pneumonia: the good news, the bad news, and the way ahead (free)

 


 

1 – Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: Statistics on the burden of dementia: need for stronger data – The Lancet (free)

“In 2016, globally, 43·8 million individuals lived with dementia, increased from 20.2 million in 1990; dementia was the fifth leading cause of death globally (2·4 million) and more women than men had dementia” (via @TheLancet see Tweet with infographic)

 

2 – Sex differences in faecal occult blood test screening for colorectal cancer – British Journal of Surgery (free)

Commentaries: Screen­ing for colorectal can­cer spares male pa­tients from in­tense treat­ments – University of Helsinki (free) AND FOBT Colorectal Cancer Screening Only Effective in Men – Medscape (free registration required)

 

3 – Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study – Canadian Medical Association Journal (free)

Commentaries: Study finds alternative to antipsychotic medication for seniors also has drawbacks – The Globe and Mail (free) AND Trazadone linked to more falls, major fractures in dementia patients – UPI (free) AND Trazadone associated with similar risk of falls and major fractures as antipsychotics in seniors with dementia – Canadian Medical Association Journal (free) AND Aggression in Dementia: Alternatives to Antipsychotics Also Have Side Effects – MedicalResearch.com (free)

 

4 – Review: Therapy and Management of Pneumocystis jirovecii – Infection – Journal of Fungi (free)

This article belongs to the Special Issue Treatments for Fungal Infections (free reviews)

 

5 – Arterial thrombosis in unusual sites: A practical review – European Journal of Haematology (free)

 

6 – Survey Snapshot: What Would Accelerate the Adoption of Value-Based Care? – NEJM Catalyst (free)

 

7 – Ten simple rules for collaboratively writing a multi-authored paper – PLOS Computational Biology (free) (via @Abraham_RMI)

 

8 – Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications: A Systematic Review – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Some research may be encouraging ineffective prescriptions, says new study – McGill University (free)

“Our point is not to condemn these individual trials. Instead, we are saying that—when you zoom out and look at what’s happening at the level of the forest—the trees begin to look less healthy.” (from McGill University)

 

9 – Viewpoint: A Global Public Health Victory for Tobacco Plain-Packaging Laws in Australia – JAMA Internal Medicine (free)

 

10 – Long-Term Protection After Fractional-Dose Yellow Fever Vaccination: Follow-up Study of a Randomized, Controlled, Noninferiority Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Study affirms fractional dosing with yellow fever vaccine – CIDRAP (free)

Related: Fractional-Dose Yellow Fever Vaccination (free research and perspective)

 


 

1 – Guideline: Urinary tract infection (catheter-associated): antimicrobial prescribing – National Institute for Health and Care Excellence (free)

Related: NICE Antimicrobial Prescribing Guidelines (free guidelines and resources)

 

2 – SEOM clinical practice guideline: management and prevention of febrile neutropenia in adults with solid tumors (2018) – Clinical and Translational Oncology (free)

Related: Guideline: Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy (free guidelines on the subject)

 

3 – Genome-edited baby claim provokes international outcry – Nature (free)

See also: A Reckless and Needless Use of Gene-Editing on Human Embryos – The Atlantic (free) AND Chinese researcher claims first gene-edited babies – Associated Press (free) AND EXCLUSIVE: Chinese scientists are creating CRISPR babies – MIT Technology Review (free) AND Expert reaction to reports of the first genome edited baby – Science Media Centre (free) AND What we know — and what we don’t — about the claim of world’s first gene-edited babies – STAT (free)

 

4 – Implant Files – The International Consortium of Investigative Journalists (free articles)

News Releases: Medical Devices Harm Patients Worldwide As Governments Fail On Safety (free) AND ICIJ publishes new investigation: the Implant Files (free) AND About The Implant Files Investigation (free)

Commentaries: How lobbying blocked European safety checks for dangerous medical implants – The BMJ (free) AND Revealed: faulty medical implants harm patients around world – The Guardian (free) AND Medical device rules need ‘drastic change’ to protect patients – BBC (free)

 

5 – Clinical Practice Guideline: Maintenance Intravenous Fluids in Children – Pediatrics (free)

News Release: Evidence-based guideline recommends isotonic solutions for children who need intravenous fluids – AAP News (free)

 

6 – Podcast: #127 STIs: Syphilis, Gonorrhea and Chlamydia – The Curbsiders Internal Medicine Podcast (free)

 

7 – Ann Robinson’s research reviews, 26 November 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 

8 – Guideline Synopsis: Diagnosis and Management of Nonalcoholic Liver Disease – JAMA (free for a limited period)

 

9 – Acute Liver Failure: Evidence-Based Evaluation and Management – emDocs (free)

 

10 – 2018 ACC Expert Consensus Decision Pathway on Novel Therapies for Cardiovascular Risk Reduction in Patients With Type 2 Diabetes and Atherosclerotic Cardiovascular Disease – Journal of the American College of Cardiology (free)

 


 

1 – AAPT Diagnostic Criteria for Fibromyalgia – the Journal of Pain (free)

Related Guidelines: EULAR revised recommendations for the management of fibromyalgia (free) AND Canadian Guidelines for the diagnosis and management of fibromyalgia syndrome: Executive summary (free)

 

2 – Green‐top Guideline: Care of Women with Obesity in Pregnancy – Royal College of Obstetricians and Gynaecologists (free)

 

3 – Opioid-Prescribing Guidelines for Common Surgical Procedures: An Expert Panel Consensus – Journal of the American College of Surgeons (free)

Commentary: Johns Hopkins Experts Create Opioid Prescribing Guidelines For 20 Common Surgical Procedures – Johns Hopkins Newsroom (free)

 

4 – Coronary Physiology Beyond Coronary Flow Reserve in Microvascular Angina: JACC State-of-the-Art Review – Journal of the American College of Cardiology (free)

 

5 – Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study – Critical Care (free)

Commentaries: Over half of former ICU patients in the UK report symptoms of psychological disorders – BioMed Central (free) AND ICU stay can lead to depression – Reuters (free)

 

6 – Dietary Patterns and Breast Cancer Risk: A Systematic Review – Anticancer Research (free)

 

7 – A systematic review of the next‐day effects of heavy alcohol consumption on cognitive performance – Addiction (free)

 

8 – Effect of testing for cancer on cancer‐ or venous thromboembolism (VTE)‐related mortality and morbidity in people with unprovoked VTE – Cochrane Library (free)

Summary: Effect of testing for cancer (on cancer and blood clot-related death and illness) in people with unprovoked blood clots in the legs and lungs – Cochrane Library (free)

 

9 – Cannabinoids for Chronic Pain – Therapeutics Initiative (free)

Related: Meta-Analysis: Cannabinoids for the Treatment of Chronic Noncancer Pain Conditions (free) AND Guideline for Prescribing Medical Cannabinoids in Primary Care (free article and commentary)

“At the present time we lack good evidence that any cannabis-derived product works for chronic pain”

 

10 – Diagnosis and Management of Primary Biliary Cholangitis – The American Journal of Gastroenterology (free)

Related Guidelines: Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases – Hepatology (free) AND The British Society of Gastroenterology/UK-PBC primary biliary cholangitis treatment and management guidelines – Gut (free)

 


 

1 – Multicenter Trial of a Combination Probiotic for Children with Gastroenteritis – New England Journal of Medicine (link to abstract – $ for full-text)

Related Study: Lactobacillus rhamnosus GG versus Placebo for Acute Gastroenteritis in Children – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Two studies find probiotic therapy ineffective against stomach flu, diarrhea – Reuters (free) AND Probiotics no help to young kids with stomach virus – Washington University in St. Louis (free) AND Probiotics Found To Be Ineffective For Easing Symptoms Of Kids’ Stomach Bugs – NPR (free)

 

2 – Global, regional, and national burden of tuberculosis, 1990–2016: results from the Global Burden of Diseases, Injuries, and Risk Factors 2016 Study – The Lancet Infectious Diseases (free)

Invited Commentary: Global burden of tuberculosis: where we are and what to do – The Lancet Infectious Diseases (free)

Related: Global Tuberculosis Report 2018 – World Health Organization (free report and commentaries)

 

3 – Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses – The BMJ (free)

Commentaries: Night shifts worsen diabetes risk for unhealthy women – OnMedica (free) AND Night shifts and unhealthy lifestyle linked to particularly high risk of type 2 diabetes – MedicalXpress (free) AND Unhealthy nurses working irregular night shifts at high diabetes risk – Nursing Times (free)

 

4 – Food sources of fructose-containing sugars and glycaemic control: systematic review and meta-analysis of controlled intervention studies – The BMJ (free)

Commentary: Sugary Drinks Are More Harmful To Diabetics Than Sweetened Foods, According To Large-Scale Research Review – IFLScience (free)

 

5 – Recommendations on the Use of Ultrasound Guidance for Adult Thoracentesis: A Position Statement of the Society of Hospital Medicine – Journal of Hospital Medicine (free)

 

6 – Evaluation of the clinical outcomes of telehealth for managing diabetes: A PRISMA-compliant meta-analysis – Medicine (free)

 

7 – Effect of diet protein restriction on progression of chronic kidney disease: A systematic review and meta-analysis – PLOS One (free)

 

8 – Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births – BMC Medicine (free)

 

9 – Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review – JNCI: Journal of the National Cancer Institute (free)

Commentary: Adverse Mental Health Outcomes in Breast Cancer Survivors – The ASCO Post (free)

“There is compelling evidence of an increased risk of anxiety, depression and suicide, and neurocognitive and sexual dysfunctions in breast cancer survivors compared with women with no prior cancer.”

 

10 – Depression, antidepressants, and the risk of non-valvular atrial fibrillation: A nationwide Danish matched cohort study – European Journal of Preventive Cardiology (free)

Commentary: Depressed people have an increased risk of atrial fibrillation – European Society of Cardiology (free) AND Study: Depressed patients see up to 7-fold higher risk for AFib – Cardiovascular Business (free)

 


 

1 – Guideline: Management of Neonates Born at ≤34 6/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis – Pediatrics (free)

Related Guidance: Management of Neonates Born at ≥35 0/7 Weeks’ Gestation With Suspected or Proven Early-Onset Bacterial Sepsis – Pediatrics (free)

News Release: New sepsis guidance addresses epidemiology, microbiology, recommended empiric treatment – AAP News (free)

 

2 – Guideline: Dysmenorrhea and Endometriosis in the Adolescent – American College of Obstetricians and Gynecologists (free)

Commentary: OB/GYN Group Issues Guidance on Dysmenorrhea, Endometriosis in Adolescents – NEJM Journal Watch (free)

 

3 – Viewpoint: Protecting the Value of Medical Science in the Age of Social Media and “Fake News” – JAMA (free)

 

4 – Burnout syndrome among medical residents: A systematic review and meta-analysis – PLOS One (free)

 

5 – Things We Do For No Reason: Routine Chest Radiographs after Uncomplicated Thoracentesis – Journal of Hospital Medicine (free PDF)

 

6 – Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists – PLOS Medicine (free) (via @EricTopol)

Commentaries: AI matched, outperformed radiologists in screening X-rays for certain diseases – Stanford Medicine (free)

 

7 – Predicting the risk of emergency admission with machine learning: Development and validation using linked electronic health records – PLOS Medicine (free)

Commentary: Machine learning can help healthcare workers predict whether patients may require emergency hospital admission, new study finds – University of Oxford (free)

 

8 – Why A New Study Says Scientists Should Use Twitter – Forbes (free) (via @onisillos)

Related: Scientists on Twitter: Preaching to the choir or singing from the rooftops? (link to study and perspectives on the subject)

 

9 – A review of antibiotic prophylaxis for traveler’s diarrhea: past to present – Tropical Diseases, Travel Medicine and Vaccines (free)

 

10 – Association of Concussion With the Risk of Suicide: A Systematic Review and Meta-Analysis – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Concussions tied to doubled risk of suicide – Reuters (free) AND Suicide Risk Doubles After Concussion – Medscape (free registration required)

 


 

1 – Draft Recommendation Statement: Prevention of Human Immunodeficiency Virus (HIV) Infection: Pre-Exposure Prophylaxis – U.S. Preventive Services Task Force (free)

Commentaries: Panel recommends everyone at high risk of getting HIV be offered a prevention pill – STAT (free) AND U.S. officials recommend use of PrEP pills to stop spread of HIV – UPI (free)

Related Clinical Guidelines: HIV Pre-exposure Prophylaxis (free articles)

 

2 – Critical appraisal and systematic review of guidelines for perioperative diabetes management: 2011–2017 – Endocrine (free)

Source: Hospital Medicine Virtual Journal Club

 

3 – Intermediate Diabetes Outcomes in Patients Managed by Physicians, Nurse Practitioners, or Physician Assistants: A Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Diabetes outcomes similar when primary care provided by NPs, PAs, or physicians, study finds – ACP Internist Weekly (free) AND Diabetics Cared for by NPs, PAs Do as Well as Those in Physicians’ Care – NEJM Journal Watch (free)

 

4 – Preoperative fasting in children: review of existing guidelines and recent developments – British Journal of Anaesthesia (free)

 

5 – Replication failures in psychology not due to differences in study populations – Nature (free)

See also: 28 classic and contemporary psychology findings replicated in more than 60 laboratories each across three dozen nations and territories – Centers for Open Science (free)

Related: Evaluating the Replicability of Social Science Experiments (link to abstract and commentaries) AND Essay: The Experiments Are Fascinating. But Nobody Can Repeat Them – The New York Times (10 articles per month are free)

 

6 – Overall Survival with Palbociclib and Fulvestrant in Advanced Breast Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Drug improves survival in metastatic breast cancer – Northwestern University (free)

 

7 – Report: 2018 Access to Medicine Index – Access to Medicine Foundation (free PDF)

Commentaries: Big pharma leaves big gaps: drugmakers urged to do more for poor – Reuters (free) AND Big pharma ‘failing to develop urgent drugs for poorest countries’ – The Guardian (free)

 

8 – Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events – Cochrane Library (free)

Summary: Ezetimibe for the prevention of heart disease and death – Cochrane Library (free)

In individuals with established atherosclerotic cardiovascular disease, Ezetimibe has modest beneficial effects, primarily driven by a reduction in non‐fatal MI and non‐fatal stroke, but with little or no effect on clinical fatal endpoints.

 

9 – Updated European Consensus Statement on diagnosis and treatment of adult ADHD – European Psychiatry (free)

 

10 – Improving the quality of life of care home residents with dementia: Cost-effectiveness of an optimized intervention for residents with clinically significant agitation in dementia – Alzheimer’s & Dementia (link to abstract – $ for full-text)

Commentaries: Care homes with dementia ‘carer champions’ reduce agitation and antipsychotics – carehome.co.uk (free) AND Improving dementia care and treatment saves thousands of pounds in care homes – University of Exeter (free)

 


 

1 – World malaria report 2018 – World Health Organization (free PDF)

News Release: WHO and partners launch new country-led response to put stalled malaria control efforts back on track (free)

Commentaries: WHO reports malaria setbacks; groups launch response plan – CIDRAP (free) AND Malaria on the rise in more than 13 countries, experts warn – CNN (free) AND The Fight Against Malaria Has Reached a Standstill – The New York Times (10 articles per month are free) AND Faltering malaria fight should refocus on high-risk countries, says WHO – Reuters (free)

 

2 – Risk of sexual transmission of human immunodeficiency virus with antiretroviral therapy, suppressed viral load and condom use: a systematic review – Canadian Medical Association Journal (free)

News Release: Negligible risk of transmitting HIV during sex when viral load is suppressed (free)

Related: UNAIDS Explainer: UNDETECTABLE = UNTRANSMITTABLE (free report and commentaries)

 

3 – Workplace bullying and workplace violence as risk factors for cardiovascular disease: a multi-cohort study – European Heart Journal (free)

Editorial: Victimization in the workplace: a new target for cardiovascular prevention? (free)

Commentaries: Bullying and violence at work increases the risk of cardiovascular disease – European Society of Cardiology (free) AND Workplace bullying and violence tied to higher risk of heart problems – Reuters (free)

 

4 – Zackary Berger’s weekly research reviews, 19 November – The BMJ Opinion (free)

 

5 – Abraar Karan: Has the physical exam had its day? – The BMJ Opinion (free)

“Seeing patients in clinic today, I know that putting my stethoscope on them has a therapeutic effect, even if as their doctor, I am quite certain their heart and lungs are normal. However, this doesn’t mean the physical exam should not evolve.” (via @AbraarKaran see Tweet)

 

6 – Prevalence of Falls and Fall‐Related Outcomes in Older Adults with Self‐Reported Vision Impairment – Journal of the American Geriatrics Society (free)

Commentaries: Study: Impaired vision raises risk of falls in older adults – UPI (free) AND Having poor vision can raise risk for falls among older adults – American Geriatrics Society (free)

 

7 – AR101 Oral Immunotherapy for Peanut Allergy – New England Journal of Medicine (free)

Editorial: Oral Desensitization to Peanuts (free)

Commentaries: Oral Immunotherapy Desensitizes Youth with Peanut Allergy – NEJM Journal Watch (free) AND Peanut allergy treatment ‘in sight’ – BBC (free) AND Peanut allergy treatment is effective but not always easy to tolerate, new review shows – STAT (free)

 

8 – Policy Statement: The Role of Pediatricians in Global Health – Pediatrics (free)

News Release: Defining pediatricians’ role in global health: 10 recommendations (free)

 

9 – Development and Validation of a Deep Learning-Based Automatic Detection Algorithm for Active Pulmonary Tuberculosis on Chest Radiographs – Clinical Infectious Diseases (free PDF)

Commentary: Algorithm outperforms radiologists in detecting active pulmonary TB – Healio (free registration required)

 

10 – Development and Validation of a Deep Learning Algorithm for Improving Gleason Scoring of Prostate Cancer – Cornell University Library (free PDF)

Commentary: Google deep-learning system grades prostate cancer with 70% accuracy – AI in Healthcare (free)

 


 

1 – Prevalence of potentially inappropriate prescribing in older people in primary care and its association with hospital admission: longitudinal study – The BMJ (free)

Editorial: Tackling potentially inappropriate prescribing (free)

Commentary: Half of older patients exposed to potentially inappropriate prescribing – MedicalXpress (free)

 

2 – Twenty Year Trends and Sex Differences in Young Adults Hospitalized with Acute Myocardial Infarction: The ARIC Community Surveillance Study – Circulation (free for a limited period)

Commentaries: Heart attacks are becoming more common in younger people, especially women – AHA News (free) AND Greater Need for Cooperative Care in Women’s Heart Health, Two Studies Suggest – TCTMD (free)

 

3 – Clinical Practice Guideline on Screening for Colorectal Cancer in Individuals With a Family History of Nonhereditary Colorectal Cancer or Adenoma: The Canadian Association of Gastroenterology Banff Consensus – Gastroenterology (free)

 

4 – Nonoperative Management of Uncomplicated Appendicitis Among Privately Insured Patients – JAMA Surgery (free for a limited period)

Editorial: Treating the Patient With Appendicitis, Not Just the Appendicitis (free)

Related Randomized Trial: Antibiotic Therapy Alone Seems Reasonable for Uncomplicated Appendicitis (link to abstract, commentaries and resources on the subject)

 

5 – Diagnosis of Primary Ciliary Dyskinesia. An Official American Thoracic Society Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine (free)

 

6 – No More FOMO: Limiting Social Media Decreases Loneliness and Depression – Journal of Social and Clinical Psychology (free PDF)

Commentary: Is Social Media Making You Depressed and Lonely? – MedicalResearch.com (free)

 

7 – Clinically Diagnosing Pertussis-associated Cough in Adults and Children: Chest Guideline and Expert Panel Report (free)

Commentary: CHEST Guidelines for Clinical Diagnosis of Pertussis-Associated Cough – Pulmonology Advisor (free)

 

8 – Omega‐3 fatty acid addition during pregnancy – Cochrane Library (free)

Summary: Omega-3 fatty acid addition during pregnancy – Cochrane Library (free)

Commentaries: Omega-3 in pregnancy reduces the risk of premature birth: new evidence – Evidently Cochrane (free) AND Omega-3 supplements in pregnancy reduce the risk of premature birth – The Conversation (free)

 

9 – Dietary fat: From foe to friend? – Science (free for a limited period)

Commentary: Dietary fat is good? Dietary fat is bad? Coming to consensus – Harvard T.H. Chan School of Public Health (free)

 

10 – Human Resting Energy Expenditure Varies with Circadian Phase – Current Biology (free for a limited period)

Commentaries: How many calories do you burn? It depends on time of day – Cell Press (free) AND Study: Calories burned depend on time of day – UPI (free) AND What time of day do we burn the most calories? – Medical News Today (free) AND Here’s When Your Body Burns the Most Calories, According to a New Study – TIME (free) AND Eat Carbs in the Morning, Fat at Night? – MedicalResearch.com (free)

 


 

1 – Evaluation and Management of Youth-Onset Type 2 Diabetes: A Position Statement by the American Diabetes Association – Diabetes Care (free PDF)

 

2 – Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 – World Journal of Surgery (free)

 

3 – Perspective: Addressing Health-Related Misinformation on Social Media – JAMA (free for a limited period)

 

4 – American Academy of Pediatrics – Committee on Infectious Diseases and the Pediatric Infectious Diseases Society: Five Things Physicians and Patients Should Question – Choosing Wisely (free)

Commentary: Choosing Wisely: 5 Antibiotic Strategies to Avoid in Children – NEJM Journal Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

5 – Sodium glucose cotransporter 2 inhibitors and risk of serious adverse events: nationwide register based cohort study – The BMJ (free)

Commentaries: New diabetes drug may increase the risk of serious adverse events – Karolinska Institutet (free) AND SGLT2 Inhibitors Tied to Increased Risk for Amputation, Diabetic Ketoacidosis – NEJM Journal Watch (free) AND SGLT2 Inhibitor Amputation Risk Seen in Real-World Diabetes Study – Medscape (free registration required)

 

6 – Review: A time to fast – Science (free for a limited period) (via @EricTopol)

 

7 – Review: Interruption and Reversal of Direct Oral Anticoagulants in Preprocedural and Acute Settings – Journal of the American Board of Family Medicine (free)

Source: Medscape

 

8 – Acute mesenteric ischaemia: a pictorial review – Insights into Imaging (free)

 

9 – Interventions during pregnancy to prevent preterm birth: an overview of Cochrane systematic reviews – Cochrane Library (free)

Summary: Ways to help pregnant women avoid preterm birth – Cochrane Library (free)

 

10 – Prophylactic Intravenous Hydration to Protect Renal Function From Intravascular Iodinated Contrast Material (AMACING): Long-term Results of a Prospective, Randomised, Controlled Trial – EclinicalMedicine (free)

Related: Post-Contrast Acute Kidney Injury (free reviews) AND Does contrast cause kidney injury? The evidence (free) AND Meta-Analysis: Acute Kidney Injury After Computed Tomography (link to abstract and commentaries)

 


 

1 – Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS – New England Journal of Medicine (free)

“Prednisone treatment during the first 4 weeks after the initiation of ART for HIV infection resulted in a lower incidence of tuberculosis-associated immune reconstitution inflammatory syndrome than placebo, without evidence of an increased risk of severe infections or cancers.”

 

2 – Effects of a low carbohydrate diet on energy expenditure during weight loss maintenance: randomized trial – The BMJ (free)

Commentaries: Expert reaction to study looking at low carbohydrate diets and weight maintenance – Science Media Centre (free) AND How a Low-Carb Diet Might Help You Maintain a Healthy Weight – The New York Times (10 articles per month are free) AND Low carb diets can help maintain weight loss by increasing number of calories burned – The BMJ (free)

 

3 – Increasing Safe Outpatient Management of Emergency Department Patients With Pulmonary Embolism: A Controlled Pragmatic Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Electronic Decision Support Facilitates Home Discharge of Some PE Patients From ER – MedicalResearch.com (free) AND EMR-Integrated Tool Lets More PE Patients Be Discharged from the ED – NEJM Journal Watch (free)

 

4 – Perspective: Benjamin Mazer: Are medical errors a huge problem that’s simple to fix? – The BMJ Opinion (free)

 

5 – Comparative safety of immune checkpoint inhibitors in cancer: systematic review and network meta-analysis – The BMJ (free)

 

6 – Review: Neuroinfections caused by fungi – Infection (free)

 

7 – Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment – Cochrane Library (free)

Summary: Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment – Cochrane Library (free)

“The evidence on vitamin and mineral supplements as treatments for mild cognitive Impairment is very limited. “

 

8 – One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory – Journal of Clinical Psychiatry (link to abstract – $ for full-text)

Commentaries: When Adolescents Give Up Pot, Their Cognition Quickly Improves – NPR (free) AND Stopping Cannabis Tied to Memory Improvements – NEJM Journal Watch (free)

 

9 – Long-term Survival following Multivessel Revascularization in Patients with Diabetes (FREEDOM Follow-On Study) – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Long-term FREEDOM: At Nearly 8 years, CABG Maintains Mortality Benefit Over PCI – TCTMD (free) AND FREEDOM Follow-On Study Findings Further Support CABG Over PCI in DM Patients With CAD – American College of Cardiology (free) AND AHA: CABG Still Better for Multivessel Disease in Diabetes – MedPage Today (free registration required)

 

10 – Antipsychotic drug use and pneumonia: Systematic review and meta-analysis – Journal of Psychopharmacology (link to abstract – $ for full-text)

Commentary: Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests – Psychiatric News Alert (free)

Although antipsychotic use was associated with a higher risk of pneumonia, the researchers stopped short of claiming causality, citing a lack of data from randomized, controlled trials and a failure of observational studies to control for relevant confounders like tobacco use and weight.” (from Psychiatric News Alert)

 


 

1 – Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Unhealthy Alcohol Use (free) AND Unhealthy Alcohol Use in Primary Care—The Elephant in the Examination Room (free)

Author Interview: USPSTF Recommendation: Screening and Interventions for Unhealthy Alcohol Use (free audio)

JAMA Patient Page: Screening and Counseling to Reduce Unhealthy Alcohol Use (free)

 

2 – 2018 IDSA Clinical Practice Guideline for the Management of Outpatient Parenteral Antimicrobial Therapy – Clinical Infectious Diseases (free) (via @ABsteward)

Commentary: Updated Guidelines Advise on Outpatient Parenteral Antimicrobial Therapy – Pharmacy Times (free) AND ID specialist input improves outcomes for outpatient parenteral antimicrobial therapy – Infectious Diseases Society of America (free)

 

3 – Effect of a Pharmacist-Led Educational Intervention on Inappropriate Medication Prescriptions in Older Adults: The D-PRESCRIBE Randomized Clinical Trial – JAMA (free)

Video Summary: Effect of a Pharmacist-Led Intervention on Inappropriate Prescriptions in Older Adults (free)

 

4 – Effect of Exercise Intervention on Functional Decline in Very Elderly Patients During Acute Hospitalization: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentaries: A Novel Exercise Intervention and Functional Status in Very Elderly Patients During Acute Hospitalization – JAMA Internal Medicine (free for a limited period) AND Exercise intervention benefits elderly in hospital – OnMedica (free)

Author Interview: Effect of Exercise Intervention on Functional Decline in Very Elderly Patients (free audio)

Videos: Morning Exercise Session (free) AND Evening Exercise Session (free) AND Balance and Gait Retraining Exercises (free)

 

5 – Top 8 Healthcare Predictions for 2019 – Forbes (free)

 

6 – Supraventricular Arrhythmias: Clinical Framework and Common Scenarios for the Internist – Mayo Clinic Proceedings (free)

Source: Hospital Medicine Virtual Journal Club

 

7 – Treatment and Prevention of Recurrent Lower Urinary Tract Infections in Women: A Rapid Review with Practice Recommendations – The Journal of Urology (free)

 

8 – Review: Advances in optimizing the prescription of antibiotics in outpatient settings – The BMJ (free for a limited period)

 

9 – Clinical Report: Sport-Related Concussion in Children and Adolescents – Pediatrics (free)

Commentaries: Concussion management embraces earlier light exercise, earlier return to school – AAP News Release (free) AND Pediatrics Group Updates Guidance on Sports-Related Concussion – NEJM Journal Watch (free)

 

10 – Attributable deaths and disability-adjusted life-years caused by infections with antibiotic-resistant bacteria in the EU and the European Economic Area in 2015: a population-level modelling analysis – The Lancet Infectious Diseases (free)

Commentaries: Public health burden of antimicrobial resistance in Europe – The Lancet Infectious Diseases (free) AND 33,000 people die every year due to infections with antibiotic-resistant bacteria – European Centre for Disease Prevention and Control (ECDC) (free) AND European study: 33,000 deaths a year from resistant infections – CIDRAP (free)

 


 

1 – The Physical Activity Guidelines for Americans – JAMA (free)

Editorial: New Physical Activity Guidelines: A Call to Activity for Clinicians and Patients (free)

Video Summary: Physical Activity Guidelines for Americans, 2nd Edition (free)

Commentaries: New Physical Activity Guidelines Urge Americans: Move More, Sit Less – NPR (free) AND HHS Releases Physical Activity Guidelines for Americans, 2nd edition – U.S. Department of Health & Human Services (free)

 

2 – Withdrawal of pharmacological treatment for heart failure in patients with recovered dilated cardiomyopathy (TRED-HF): an open-label, pilot, randomised trial – The Lancet (free)

Commentaries: Stopping medication for heart failure with improved ejection fraction – The Lancet (free) AND Remission, Not Cure: No Weaning Off Meds for Dilated Cardiomyopathy Patients, Says TRED-HF – TCTMD (free) AND Drug Withdrawal Inadvisable in ‘Recovered’ Dilated Cardiomyopathy – Medscape (free registration required)

 

3 – Randomized Trial of Endoscopic or Open Vein-Graft Harvesting for Coronary-Artery Bypass – New England Journal of Medicine (free)

Commentaries: Endoscopic Vein-Graft Harvest for CABG Associated With Similar MACE, Less Pain vs Open Procedure: REGROUP – TCTMD (free) AND AHA: Endoscopic Vein-Graft Harvesting Redeems Itself in CABG – MedPage Today (free)

 

4 – Perspective: Getting Rid of Stupid Stuff – New England Journal of Medicine (free)

 

5 – Alex Nowbar’s research reviews, 12 November 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 

6 – Last Month in Oncology with Dr. Bishal Gyawali – The Health Care Blog (free)

 

7 – The Misunderstood Coagulopathy of Liver Disease: A Review for the Acute Setting – West Journal of Emergency Medicine (free)

 

8 – WHO Report on Surveillance of Antibiotic Consumption: 2016 – 2018 Early implementation – World Health Organization (free)

Commentary: WHO uncovers big national variations in antibiotics consumption – Reuters (free)

 

9 – SGLT2 inhibitors for primary and secondary prevention of cardiovascular and renal outcomes in type 2 diabetes: a systematic review and meta-analysis of cardiovascular outcome trials – The Lancet (link to abstract – $ for full-text)

Commentary: SGLT2 Inhibitors and CV and Renal Outcomes in Type 2 Diabetes – American College of Cardiology (free)

 

10 – Risk of Malignant Ovarian Cancer Based on Ultrasonography Findings in a Large Unselected Population – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Most simple ovarian cysts require no treatment, surveillance – UPI (free) AND Less surveillance needed for simple ovarian cysts – University of California, San Francisco (free)

“New study finds that simple cysts should be considered normal and ignored” (from The University of California)

 


 

#AHA2018 – Highlights from the AHA Scientific Sessions 2018

 

 

1 – Global Burden of Disease Study 2017 – The Lancet (8 free articles)

See also: Infographics with GBD 2017 Study Highlights – Institute for Health Metrics and Evaluation (all free) AND Updated GBD Compare Visualization Tool – Institute for Health Metrics and Evaluation (free resource)

All eight Global Burden of Disease 2017 papers providing 38 billion estimates of 359 diseases & injuries & 84 risk factors in 195 countries & territories” (via @TheLancet see Tweet)

 

2 – #AHA2018 – 2018 AHA/ACC Guideline on the Management of Blood Cholesterol – Circulation – A Report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines (free PDF)

Summary: 2018 ACC/AHA Multisociety Guideline on the Management of Blood Cholesterol – American College of Cardiology (free)

See also: Cholesterol Guideline Hub (free resources)

 

3 – #AHA2018 – Use of Risk Assessment Tools to Guide Decision-Making in the Primary Prevention of Atherosclerotic Cardiovascular Disease – A Special Report From the American Heart Association and American College of Cardiology (free PDF)

Summary: Use of Risk Assessment Tools to Guide Decision-Making in ASCVD Prevention – American College of Cardiology (free)

 

4 – #AHA2018 – Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease – New England Journal of Medicine (free)

Editorial: VITAL Signs for Dietary Supplementation to Prevent Cancer and Heart Disease (free)

Commentaries: Vitamin D And Fish Oil Supplements Mostly Disappoint In Long-Awaited Research Results – NPR (free) AND Fish Oil And Vitamin D Pills No Guard Against Cancer Or Serious Heart Trouble – Kaiser Health News (free)

 

5 – #AHA2018 – Marine n−3 Fatty Acids and Prevention of Cardiovascular Disease and Cancer – New England Journal of Medicine (free)

Commentaries: Vitamin D, omega-3 supplements do not prevent cancer or heart disease, study says – CNN (free) AND Vitamin D and Fish Oils Are Ineffective for Preventing Cancer and Heart Disease – The New York Times (10 articles per month are free)

Related Systematic Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (free review and commentaries)

 

6 – #AHA2018 – Amarin’s Fish-Oil-Derived Drug Shows Great Promise — With Big Caveats – Forbes (free) (via @cardiobrief)

Original Article: Cardiovascular Risk Reduction with Icosapent Ethyl for Hypertriglyceridemia – New England Journal of Medicine (free)

“what seriously bothered five of the six cardiologists I spoke to was that the mineral oil had not behaved as a placebo at all.”

 

7 – Effective healthcare cost-containment policies: a systematic review – Health Policy (free)

 

8 – Perioperative alcohol cessation intervention for postoperative complications – Cochrane Library (free)

Summary: Effects of perioperative alcohol cessation interventions on postoperative complications following surgery – Cochrane Library (free)

Intensive alcohol cessation interventions offered for four to eight weeks to participants undergoing all types of surgical procedures to achieve complete alcohol cessation before surgery probably reduced the number of postoperative complications.”

 

9 – 2018 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation – Canadian Journal of Cardiology (free)

 

10 – “Ten Commandments” for the 2018 ESC/EACTS Guidelines on Myocardial Revascularization – European Heart Journal (free)

See Original Article: ESC/EACTS Guidelines on Myocardial Revascularization (free)

 


 

1 – Guideline: Management of physical health conditions in adults with severe mental disorders – World Health Organization (free PDF)

News Release: WHO guidelines: Management of physical health conditions in adults with severe mental disorders (free)

WHO Video: Improving the physical health of people with severe mental disorders (free)

 

2 – A Trial of a Triple-Drug Treatment for Lymphatic Filariasis – New England Journal of Medicine (free)

Editorial: Advancing toward the Elimination of Lymphatic Filariasis (free)

Commentary: Triple-Drug Therapy Superior to Two Drugs for Treating Lymphatic Filariasis – NEJM Journal Watch (free)

 

3 – Single-Dose Zoliflodacin (ETX0914) for Treatment of Urogenital Gonorrhea – New England Journal of Medicine (link to abstract – $ for full-text)

Related Perspective: Neisseria gonorrhoeae — Rising Infection Rates, Dwindling Treatment Options – New England Journal of Medicine (free)

Commentaries: Novel antibiotic shows promise in treatment of uncomplicated gonorrhea – NIH News Release (free) AND Experimental treatment appears effective against gonorrhea in small study – STAT (free) AND Single Dose of New Oral Antibiotic Cures Most Gonorrhea – Medscape (free registration required)

 

4 – Alirocumab and Cardiovascular Outcomes after Acute Coronary Syndrome – New England Journal of Medicine (free)

Commentaries: Among heart attack survivors, drug reduces chances of second heart attack or stroke – University of Colorado Anschutz Medical Campus (free) AND Alirocumab Linked to Lower Risk for Recurrent Ischemic CV Events – NEJM Journal Watch (free)

An estimated 49 patients would need to be treated for 4 years to prevent one CV event.” (from NEJM Journal Watch)

 

5 – Gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome: common overlapping gastrointestinal disorders – Annals of Gastroenterology (free)

 

6 – Head To Head: Could artificial intelligence make doctors obsolete? – The BMJ (free)

Commentaries: Could machines using artificial intelligence make doctors obsolete? – The BMJ (free) AND Stop hyping artificial intelligence—patients will always need human doctors – The BMJ (free)

 

7 – A Deep Learning Model to Predict a Diagnosis of Alzheimer Disease by Using 18F-FDG PET of the Brain – Radiology (free for a limited period)

Commentaries: Artificial intelligence predicts Alzheimer’s years before diagnosis – Radiology Society of North America (free) AND Expert reaction to study looking at AI technology, brain imaging and Alzheimer’s disease detection – Science Media Centre (free) AND AI May Detect Alzheimer’s Years Before Diagnosis – Medscape (free registration required)

 

8 – Guideline Synopsis: Incidental Pulmonary Nodules Detected on CT Images – JAMA (free for a limited period)

 

9 – Triple therapy in the management of chronic obstructive pulmonary disease: systematic review and meta-analysis – The BMJ (free)

Commentary: Triple Therapy for COPD Tied to Fewer Exacerbations, More Pneumonia – NEJM Journal Watch (free)

 

10 – Associations between screen time and lower psychological well-being among children and adolescents: Evidence from a population-based study – Preventive Medicine Reports (free)

Commentaries: Reduced screen time for young highly recommended for well-being – San Diego State University (free) AND Children and Screens: a Little Can Do a Lot of Damage – Medscape (free registration required)

 


 

1 – 2018 ACC/AHA/HRS Guideline on the Evaluation and Management of Patients With Bradycardia and Cardiac Conduction Delay (free)

See also: Executive Summary (free) AND Summary form ACC (free) AND Bradycardia Guideline Hub (free resources)

 

2 – Basic Emergency Care: approach to the acutely ill and injured – World Health Organization (free PDF)

 

3 – Podcast: Battle of the Heart Societies: Who Is Right–the US or Europe–Regarding How to Manage Hypertension? – JAMA (free)

Related: Impact of the Discordance Between Blood Pressure Guidelines (free perspective and commentaries)

 

4 – In win for open access, two major funders won’t cover publishing in hybrid journals – Science (free)

See also: Wellcome and Gates join bold European open-access plan – Nature (free) AND Wellcome is updating its open access policy (free) AND Big funders back plan for instant free access to journals, but researchers say it is risky for science – Science|Business (free)

Related: cOAlition S: Making Open Access a Reality by 2020 (free Statement and commentaries)

 

5 – Perspective: Why Doctors Hate Their Computers – The New Yorker (free)

“Digitization promises to make medical care easier and more efficient. But are screens coming between doctors and patients?”

 

6 – Review: State-of-the-Art Diagnosis and Treatment of Hypertension in Pregnancy – Mayo Clinic Proceedings (free)

 

7 – Review: Lower extremity arterial disease in patients with diabetes: a contemporary narrative review – Cardiovascular Diabetology (free)

 

8 – Instant soups and noodles responsible for burning nearly 10,000 children each year – American Academy of Pediatrics (free)

Commentary: How Instant Soup, Noodle Burns Send Over 9500 Kids To ERs Each Year – Forbes (free)

 

9 – Vaccination and Allergic Sensitization in Early Childhood – The ALADDIN Birth Cohort – EClinicalMedicine (free)

Commentary: Link between vaccines and allergies dismissed – Karolinska Institutet (free)

 

10 – Health-motivated taxes on red and processed meat: A modelling study on optimal tax levels and associated health impacts – PLOS One (free)

Commentaries: Should there be a tax on red meat? – BBC (free) AND Taxing red meat would save many lives, research shows – The Guardian (free)

Related: To improve global health, tax the things that are killing us – Financial Times (free policies, articles and commentaries) AND Policy lessons from health taxes (free research and commentaries) AND Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND The Lancet taskforce on NCDs and economics (free series and commentaries)

 


 

1 – Clinical Practice Guidelines for Quality Palliative Care, 4th Edition – National Consensus Project’s (free)

News Release: New National Guidelines Seek to Improve Access to Palliative Care for People Living with Serious Illness (free)

Commentaries: Palliative care guidelines updated with increased focus on collaboration, communication – ACP Internist (free) AND New Palliative Care Guidelines Demand ‘Seismic Shift’ in Care – Medscape (free registration required)

 

2 – Brief summary of French guidelines for the prevention, diagnosis and treatment of hospital-acquired pneumonia in ICU – Annals of Intensive Care (free)

Related: Summary of the international clinical guidelines for the management of hospital-acquired and ventilator-acquired pneumonia (free) AND International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) AND Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society (free)

 

3 – Reduced Salt Intake for Heart Failure: A Systematic Review – JAMA Internal Medicine (free for a limited period)

Commentaries: Sodium Restriction in Heart Failure: Too Much Uncertainty—Do the Trials – JAMA Internal Medicine (free for a limited period) AND Review Questions Wisdom of Limiting Salt Intake in Heart Failure – NEJM Journal Watch (free) AND Review: Low-Sodium Diet for HF on Shaky Ground – MedPage Today (free registration required)

 

4 – Perspective: A Profusion of Diagnoses. That’s Good and Bad – The New York Times (10 articles per month are free)

“…we may also be medicalizing much of normal human behavior — labeling the healthy as diseased, and exposing them to undue risk of stigma, testing and treatment.”

 

5 – Off‐ Versus On‐Pump Coronary Surgery and the Effect of Follow‐Up Length and Surgeons’ Experience: A Meta‐Analysis – Journal of the American Heart Association (free)

Editorial: Long‐Term Survival Following Off‐Pump Coronary Surgery: Does Surgeon Experience Make a Difference? (free)

 

6 – Review: Lifestyle Modifications for Preventing and Treating Heart Failure – Journal of the American College of Cardiology (free for a limited period)

 

7 – Review: Causes and prevention of postoperative myocardial injury – European Journal of Preventive Cardiology (free)

 

8 – Review: Update on Perioperative Acute Kidney Injury – Anesthesia & Analgesia (free)

 

9 – Association of Prior Vaccination With Influenza Vaccine Effectiveness in Children Receiving Live Attenuated or Inactivated Vaccine – JAMA Network Open (free)

Commentaries: Repeated Vaccination May Protect Children From Influenza Infection – JAMA Network Open (free) AND What Getting The Flu Vaccine Every Year Does To Your Immunity – Forbes (free) AND Study: Kids’ flu vaccine protection not reduced by prior vaccination – CIDRAP (free)

 

10 – Age at last screening and remaining lifetime risk of cervical cancer in older, unvaccinated, HPV-negative women: a modelling study – The Lancet Oncology (link to abstract – $ for full-text)

Commentaries: Study finds there may be little benefit in screening women aged 55 with a negative HPV DNA test – The Lancet (free) AND New test could mean cervical cancer screening could stop sooner – OnMedica (free) AND At What Age Can We Stop Screening for Cervical Cancer? – NEJM Journal Watch (free)

 


 

1 – 2018 American Heart Association Focused Update on Advanced Cardiovascular Life Support Use of Antiarrhythmic Drugs During and Immediately After Cardiac Arrest: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care (free PDF) (via @gonzaeperez)

See also: Highlights of the 2018 Focused Updates to the American Heart Association Guidelines for CPR and ECC: Advanced Cardiovascular Life Support and Pediatric Advanced Life Support – American Heart Association (free PDF)

 

2 – 2018 American Heart Association Focused Update on Pediatric Advanced Life Support: An Update to the American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care (free PDF)

 

3 – A patient-level pooled analysis of treatment-shortening regimens for drug-susceptible pulmonary tuberculosis – Nature Medicine (link to abstract – $ for full-text)

Commentary: Pulmonary TB can be cured with shorter treatment, study finds – University of California – San Francisco (free)

 

4 – Policy Statement: Effective Discipline to Raise Healthy Children – American Academy of Pediatrics (free)

Commentaries: AAP policy opposes corporal punishment, draws on recent evidence – AAP News (free) AND Discipline vs. punishment: What works best for children? – AAP News (free) AND Pediatricians strengthen stance against spanking kids – CNN (free) AND Spanking Is Ineffective and Harmful to Children, Pediatricians’ Group Says – The New York Times (10 articles per month are free)

 

5 – Ann Robinson’s weekly research reviews, 5 November 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 

6 – Podcast: #123 Sleep Apnea Pearls and Pitfalls – The Curbsiders Internal Medicine Podcast (free audio and summary)

 

7 – Guideline Summary: Updated clinical practice guidelines on pregnancy care – Medical Journal of Australia (free for 7 days)

See full guidelines: Pregnancy Care Guidelines and related documents – Australian Government Department of Health (free)

 

8 – What Works in Youth Suicide Prevention? A Systematic Review and Meta-Analysis – EclinicalMedicine (free)

Related: 800,000 People Kill Themselves Every Year. What Can We do? (free Guidelines and commentary) AND Recommended Standard Care for People with Suicide Risk (free Guideline and commentary) AND Preventing Teen Suicide: What Does the Evidence Shows (free Guideline and commentary) AND AAP Clinical Report: Suicide and Suicide Attempts in Adolescents (free)

 

9 – Antibiotic Prophylaxis and Incidence of Endocarditis Before and After the 2007 AHA Recommendations – Journal of the American College of Cardiology (free)

Commentary: International study supports the use of antibiotic prophylaxis to prevent a life-threatening heart infection in high risk dental patients – contrary to NICE guidance that recommended against its use in the UK – The University of Sheffield (free)

 

10 – Pedestrian Fatalities Associated With Halloween in the United States – JAMA Pediatrics (free for a limited period)

Commentaries: Pedestrian fatalities increase on Halloween, particularly among children – University of British Columbia (free) AND High risk of child pedestrian deaths at Halloween – OnMedica (free) AND Really Scary! Pediatric Pedestrian Fatalities 10x Higher on Halloween – MedicalResearch.com (free)

 


 

1 – Randomized Trial of Platelet-Transfusion Thresholds in Neonates – New England Journal of Medicine (free)

Commentaries: Lower threshold for platelet transfusions appears safer – HematologyTimes (free)

 

2 – The Blood Pressure Landscape: Schism Among Guidelines, Confusion Among Physicians, and Anxiety Among Patients – Journal of the American College of Cardiology (free)

Commentary: Disagreements in Blood Pressure Guidelines Lead to Physician, Patient Confusion – Clinical Advisor (free) AND Competing hypertension guidelines: what’s a clinician to do? – Univadis (free registration required)

 

3 – Deprescribing: the fightback against polypharmacy has begun – The Pharmaceutical Journal (1 free article per month) (via @Deprescribing)

Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject) AND Deprescribing recommendations: An essential consideration for clinical guideline developers – Research in Social and Administrative Pharmacy (free)

 

4 – Case Report: Fatal Measles Virus Infection After Rituximab-Containing Chemotherapy in a Previously Vaccinated Patient – Open Forum Infectious Diseases (free)

Commentary: Fatal measles case highlights importance of herd immunity in protecting the vulnerable – Infectious Diseases Society of America (free)

 

5 – Things We Do For No Reason: Acute Treatment of Hypertensive Urgency – Journal of Hospital Medicine (free PDF)

 

6 – Perspective: Establishing the Effectiveness of Procedural Interventions: The Limited Role of Randomized Trials – JAMA (free for a limited period)

 

7 – Perspective: Accreditation, Quality, and Making Hospital Care Better – JAMA Forum (free)

Related: Questioning One of Healthcare’s Sacred Cows – Op-Med (free)

See Original Study: Hospital Accreditation not Associated with Better Outcomes in Observational Study (free study and commentaries)

 

8 – Practical approach to diastolic dysfunction in light of the new guidelines and clinical applications in the operating room and in the intensive care – Annals of Intensive Care (free)

 

9 – Stroke Prevention in Patients With Atrial Fibrillation: A Systematic Review Update – Agency for Healthcare Research and Quality (free)

Full Report: Stroke Prevention in Patients With Atrial Fibrillation: A Systematic Review Update (free PDF)

 

10 – Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: E-therapy may help ease insomnia – Reuters (free) AND Some Apps May Help Curb Insomnia, Others Just Put You To Sleep – NPR (free) AND Insomnia symptoms, overall health improve with online insomnia program – Northwestern University (free)

 


 

1 – Guidelines for the safe practice of total intravenous anaesthesia (TIVA) – Anaesthesia (free)

 

2 – Pediatric Readiness in the Emergency Department – Pediatrics (free)

News Release: Groups update joint guidance on pediatric emergency care (free)

 

3 – Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR) – The BMJ (free)

Commentary: Popular drug combination for treatment resistant depression is not more effective than a single antidepressant in primary care – University of Bristol (free)

 

4 – Report: Cell Phone Radio Frequency Radiation – National Toxicology Program (free)

Commentaries: High exposure to radio frequency radiation associated with cancer in male rats – NIH News Releases (free) AND Expert reaction to study on mobile phones and rats – Science Media Centre (free) AND Study of Cellphone Risks Finds ‘Some Evidence’ of Link to Cancer, at Least in Male Rats – The New York Times (10 articles per month are free)

 

5 – Perspective: Current and Future Landscape of Nutritional Epidemiologic Research – JAMA (free for a limited period)

 

6 – Perspective: The Emperor’s New Clothes: a Critical Appraisal of Evidence-based Medicine – International Journal of Medical Sciences (free)

 

7 – Hypoglycemia After Gastric Bypass Surgery: Current Concepts and Controversies – The Journal of Clinical Endocrinology & Metabolism (free)

 

8 – Myocarditis in Adults: ED Presentations, Evaluation, and Management – emDocs (free)

 

9 – Side Effects of Long‐Term Proton Pump Inhibitor Use: A Review – Basic & Clinical Pharmacology & Toxicology (free)

 

10 – Association of sodium intake and major cardiovascular outcomes: a dose-response meta-analysis of prospective cohort studies – BMC Cardiovascular Disorders (free)

Related: Effects of Sodium and Potassium Intake on Chronic Disease Outcomes and Risks (free report and summary) AND Urinary Sodium Excretion, Blood Pressure, Cardiovascular Disease, and Mortality (link to abstract and commentaries) AND Salt intake and Cardiovascular Disease (free report and commentary)

 


 

1 – Antimicrobial prescribing guidelines – National Institute for Health and Care Excellence (free resources)

Just Published Guidelines: Urinary tract infection (lower): antimicrobial prescribing (free) AND Urinary tract infection (recurrent): antimicrobial prescribing (free) AND Pyelonephritis (acute): antimicrobial prescribing (free) AND Prostatitis (acute): antimicrobial prescribing (free)

See also: Summary of antimicrobial prescribing guidance – managing common infections – National Institute for Health and Care Excellence (free PDF)

 

2 – Minimally Invasive versus Abdominal Radical Hysterectomy for Cervical Cancer – New England Journal of Medicine (free)

Related Study: Survival after Minimally Invasive Radical Hysterectomy for Early-Stage Cervical Cancer – New England Journal of Medicine (free)

Editorial: Surgery in Cervical Cancer – New England Journal of Medicine (free)

Commentaries: Studies Warn Against Minimally Invasive Surgery for Cervical Cancer – The New York Times (10 articles per month are free) AND More deaths seen for less invasive cervical cancer surgery – STAT (free) AND For Cervical Cancer Patients, Less Invasive Surgery Is Worse For Survival – NPR (free)

 

3 – Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3·6 million adults in the UK – The Lancet Diabetes & Endocrinology (free)

Commentaries: The association between BMI and mortality: implications for obesity prevention – The Lancet Diabetes & Endocrinology (free) AND BMI of 21-25kg/m2 linked to lowest risk of dying from cancer and heart disease – London School of Hygiene & Tropical Medicine (free) AND Being too fat or too thin ‘can cost four years of life’ – BBC (free)

 

4 – Effectiveness of plant-based diets in promoting well-being in the management of type 2 diabetes: a systematic review – BMJ Open Diabetes Research & Care (free)

Commentaries: Expert reaction to study looking at plant based or vegan diets and type 2 diabetes – Science Media Centre (free) AND Vegan diet linked to better diabetes control and wellbeing – OnMedica (free)

 

5 – Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

Summary: Preventative antibiotic therapy for people with COPD – Cochrane Library (free)

“Use of continuous and intermittent prophylactic antibiotics results in a clinically significant benefit in reducing exacerbations in COPD patients.”

 

6 – Revised Australian national guidelines for colorectal cancer screening: family history – Medical Journal of Australia (free for 7 days)

 

7 – Targeted neurotechnology restores walking in humans with spinal cord injury – Nature (free)

Editorial: Paralysed people walk again after spinal-cord stimulation (free)

Commentaries: Spinal implant helps three paralysed men walk again – BBC (free) AND Once Paralyzed, Three Men Take Steps Again With Spinal Implant – The New York Times (10 articles per month are free)

 

8 – Review: Management of Cancer-Therapy-Induced LV Dysfunction: Can the Guidelines Help? – American College of Cardiology (free) (via @md_arianemacedo)

Related: Cardio-Onco-Hematology in Clinical Practice (series of reviews and guidelines on the subject)

 

9 – Payment Designed for People: Introducing the Primary Care Outcomes Model – NEJM Catalyst (free)

 

10 – Antibiotic and acid-suppression medications during early childhood are associated with obesity – Gut (free)

Related Study: Early Antibiotic Exposure and Weight Outcomes in Young Children – Pediatrics (link to abstract – $ for full-text)

Commentaries: Expert reaction to antibiotic and antacid use in early childhood and risk of obesity – Science Media Centre (free) AND Antibiotic Exposure in Early Life Tied to Slightly Higher Obesity Risk – NEJM Journal Watch (free) AND Antibiotics, H2RAs and PPIs linked to child obesity – OnMedica (free) AND Two studies tie early antibiotic exposure to increased obesity risk – CIDRAP (free)

 


 

1 – Association of Short Interpregnancy Interval With Pregnancy Outcomes According to Maternal Age – JAMA Internal Medicine (free for a limited period)

Commentaries: Balancing the Risks and Desires for Pregnancy in Older Mothers: Increasing Morbidity, Declining Fertility – JAMA Internal Medicine (free for a limited period) AND Women ‘should leave at least a year between pregnancies’ – NHS Choices (free) AND Waiting a year between pregnancies lowers health risks, study says – CNN (free) AND Study: Do Even Older Moms Have To Wait 18 Months Between Pregnancies? – CommonHealth (free)

 

2 – Cannabis and cannabinoids for the treatment of people with chronic noncancer pain conditions: a systematic review and meta-analysis of controlled and observational studies – Pain (free)

“It seems unlikely that cannabinoids are highly effective medicines for chronic noncancer pain conditions.”

 

3 – Prevalence of Financial Conflicts of Interest Among Authors of Clinical Guidelines Related to High-Revenue Medications – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: More Than Half of Physician Guideline Authors for Expensive Medications Have Undeclared Conflicts of Interest – MedicalResearch.com (free) AND Many Clinical Guideline Authors Have Undeclared Payments – Medical Health News (free)

 

4 – Unpublished medical research ‘a threat to public health’ – BBC (free)

 

5 – Perspective: Surgical Value — Beyond Bundled Payments – NEJM Catalyst (free)

 

6 – Best practice guidelines for blunt cerebrovascular injury (BCVI) – Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine (free)

 

7 – Deep Learning for MR Angiography: Automated Detection of Cerebral Aneurysms – Radiology (free) (@EricTopol)

 

8 – Oral curcumin in elective abdominal aortic aneurysm repair: a multicentre randomized controlled trial – Canadian Medical Association Journal (free)

Editorial: Take turmeric with a grain of salt (free)

Commentary: Oral curcumin shows no benefit in reducing inflammation following vascular surgery – Canadian Medical Association Journal (free)

 

9 – Book: The Safe Food Imperative: Accelerating Progress in Low- and Middle-Income Countries – The World Bank (free PDF)

 

10 – Interventions for Preventing Thromboembolic Events in Patients With Atrial Fibrillation: A Systematic Review – Annals of Internal Medicine (free)

Commentary: DOACs in AF: Observational and Randomized Studies Don’t Always Agree – Medscape (free registration required)

 


 

1 – Report: Air pollution and child health: prescribing clean air – World Health Organization (free)

Commentaries: WHO says air pollution kills 600,000 children every year – Reuters (free) AND 90% of world’s children are breathing toxic air, WHO study finds – The Guardian (free)

Related: How air pollution is destroying our health – World Health Organization (free) AND Air pollution is the ‘new tobacco’, warns WHO head – The Guardian (free)

 

2 – Comparative Effectiveness and Safety of Bariatric Procedures for Weight Loss: A PCORnet Cohort Study – Annals of Internal Medicine (free)

Commentaries: Effectiveness and Safety of Bariatric Procedures for Weight Loss – Annals of Internal Medicine (free) AND Gastric bypass surgery associated with greater weight loss in adults – Kaiser Permanente (free)

 

3 – Modernized Classification of Cardiac Antiarrhythmic Drugs – Circulation (free)

 

4 – Drug-Induced Interstitial Lung Disease: A Systematic Review – Journal of Clinical Medicine (free)

Commentary: Drugs’ side effects in lungs ‘more widespread than thought’ – The University of Manchester (free)

 

5 – Alex Nowbar’s research reviews, 29 October 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 

6 – Podcast: #122 Headaches Advanced Class: Migraines, medication overuse, and more! – Curbsiders Internal Medicine Podcast (free audio and summary)

 

7 – What a massive database of retracted papers reveals about science publishing’s ‘death penalty’ – Science (free)

Related: A huge database of scientific retractions is live. That’s great for science. – VOX (free)

 

8 – Benefits and Harms of Antihypertensive Treatment in Low-Risk Patients With Mild Hypertension – JAMA Internal Medicine (free for a limited period)

Commentaries: Treatment for moderately high blood pressure may be best saved for those at high risk – University of Cambridge (free) AND Study Questions Whether Treating Mild Hypertension Benefits Patients – NEJM Journal Watch (free)

 

9 – European position paper on the management of patients with patent foramen ovale. General approach and left circulation thromboembolism – European Heart Journal (free)

Related: Patent foramen ovale closure, antiplatelet therapy or anticoagulation therapy alone for management of cryptogenic stroke? A clinical practice guideline – The BMJ (free)

 

10 – Genetic risk, incident stroke, and the benefits of adhering to a healthy lifestyle: cohort study of 306 473 UK Biobank participants – The BMJ (free)

Commentary: A healthy lifestyle cuts stroke risk, irrespective of genetic risk – University of Cambridge (free)

 


 

1 – Guideline: Myeloma: diagnosis and management – National Institute for Health and Care Excellence (free)

 

2 – Intravenous Iron in Patients Undergoing Maintenance Hemodialysis – New England Journal of Medicine (free)

Proactive administration of high-dose iv iron did not adversely affect mortality or CV events, but enabled reduced erythropoiesis-stimulating agent dosing and transfusion rates.” (via @NatRevNeph see Tweet)

 

3 – WHO guideline on health policy and system support to optimize community health worker programmes – World Health Organization (free PDF)

News Release: WHO launches new guideline on health policy and system support to optimize community health worker programmes (free)

Related: Health policy and system support to optimise community health worker programmes: an abridged WHO guideline – The Lancet Global Health (free)

 

4 – Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications – Cochrane Library (free)

Summary: The effect of having nutrition within the first 24 hours after bowel surgery on length of hospital stay and postoperative complications – Cochrane Library (free)

This review suggests that early enteral feeding is associated with a shorter length of hospital stay. For all other outcomes (postoperative complications, mortality, adverse events, and QoL) the findings are inconclusive.

 

5 – Perspective: Overdiagnosis of Penicillin Allergy Leads to Costly, Inappropriate Treatment – JAMA (free for a limited period)

Related: NICE: Double Check Patients with ‘Penicillin Allergy’ to Avoid Increased MRSA Risk (free) AND Antibiotic Use After Removal of Penicillin Allergy Label (link to abstract and commentaries) AND Allergy Testing in Children With Low-Risk Penicillin Allergy Symptoms (link to abstract and commentaries)

 

6 – Danish respiratory society position paper: palliative care in patients with chronic progressive non-malignant lung diseases – European Clinical Respiratory Journal (free)

 

7 – Physician burnout costs up to $17B a year, task force says – HealthcareDive (free)

Related Position Paper: The Business Case for Humanity in Healthcare – National Taskforce for Humanity in Healthcare (free PDF)

Related: Systematic Review: Prevalence of Burnout Among Physicians (link to abstract and commentaries) AND Implementing Optimal Team-Based Care to Reduce Clinician Burnout (free review and commentaries) AND Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction (link to abstract and commentaries) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and commentaries) AND The Burnout Crisis in American Medicine (free perspectives on the subject)

 

8 – The fight against non-communicable disease in emerging economies – Nature (free)

“Health-care providers in low- and middle-income countries are shifting their focus away from infections, and towards the bigger problems of diabetes and cardiovascular disease.”

 

9 – Review: Optimizing medication management for patients with cirrhosis: Evidence‐based strategies and their outcomes – Liver International (free) (via @Abraham_RMI)

 

10 – Albumin administrations can prolong survival for some people with liver disease – NIHR Signal (free)

Original Article: Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial – The Lancet (link to abstract – $ for full-text)

 


 

1 – Oxygen therapy for acutely ill medical patients: a clinical practice guideline – The BMJ (free)

News Release: New guidance recommends minimal oxygen use for most people in hospital – The BMJ (free)

 

2 – Management of antiplatelet therapy in patients undergoing elective invasive procedures. Proposals from the French Working Group on perioperative haemostasis (GIHP) and the French Study Group on thrombosis and haemostasis (GFHT). In collaboration with the French Society for Anaesthesia and Intensive Care Medicine (SFAR) (free)

 

3 – The global burden of multiple chronic conditions: A narrative review – Preventive Medicine Reports (free)

Related: Multimorbidity: A Priority for Global Health Research (free report and commentaries) AND Meta-Analysis: Effectiveness of Interventions for Managing Multiple High-Burden Chronic Diseases in Older Adults (free study and commentaries) Designing a High-Performing Health Care System for Patients with Complex Needs (several perspectives on the subject)

 

4 – Perspective: The troubling epidemic of unnecessary C-sections around the world, explained – VOX (free)

Related WHO Recommendations: Non-Clinical Interventions to Reduce Unnecessary Cesarean Sections (free guideline and commentaries)

Related The Lancet Series: Optimising Cesarean Section Use (free articles)

Related Cochrane Review: Non‐Clinical Interventions for Reducing Unnecessary Caesarean Section (free review and summary)

“The C-section rate has doubled in less than a generation, from 12 percent of all births in 2000 to 21 percent in 2015.”

 

5 – The skeptic: What precision medicine revolution? – MIT Technology Review (free)

Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free)

 

6 – Review: Similarities and differences between biliary sludge and microlithiasis: Their clinical and pathophysiological significances – Liver Research (free)

 

7 – Review: Pacemaker‐mediated arrhythmias – Journal of Arrythmia (free)

 

8 – Low-dose imipramine for refractory functional dyspepsia: a randomised, double-blind, placebo-controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Refractory functional dyspepsia: low-dose imipramine safe, effective – Univadis (free registration required)

 

9 – Angiotensin converting enzyme inhibitors and risk of lung cancer: population based cohort study – The BMJ (free)

Editorial: Angiotensin converting enzyme inhibitors and lung cancer (free)

Commentaries: Blood pressure drug linked to possible small increased risk of lung cancer – NHS Choices (free) AND Expert reaction to study looking at blood pressure drugs and lung cancer risk – Science Media Centre (free)

 

10 – Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis – The BMJ (free)

“Using the adjuvant recombinant subunit vaccine might prevent more cases of herpes zoster than using the live attenuated vaccine, but the adjuvant recombinant subunit vaccine also carries a greater risk of adverse events at injection sites.”

 


 

1 – Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU – New England Journal of Medicine (free for a limited period)

Editorial: Proton-Pump Inhibitor Prophylaxis in the ICU — Benefits Worth the Risks? (free for a limited period)

Proton pump inhibitors are minimally effective to reduce GI bleeding among the critically ill folks at high risk for stress ulcers. Takeaways: no role for routine PPI for any patients on the WARDS, and shouldn’t be considered ‘routine’ in the ICU” (via @AnilMakam see Tweet)

 

2 – Effect of Early Sustained Prophylactic Hypothermia on Neurologic Outcomes Among Patients with Severe Traumatic Brain Injury: The POLAR Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Hypothermia After Traumatic Brain Injury (free)

Commentary: Hypothermia for Severe TBI Called into Question – NEJM Journal Watch (free)

 

3 – Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Lessons From ARDS for Non-ARDS Research: Remembrance of Trials Past (free)

“Among patients in the ICU receiving invasive ventilation, a strategy with low tidal volume was not more effective than a strategy using intermediate tidal volume.”

 

4 – Association of Weather with Day-to-Day Incidence of Myocardial Infarction: A SWEDEHEART Nationwide Observational Study – JAMA Cardiology (free)

Commentaries: Your risk of a heart attack could increase as it gets colder, study says – CNN (free) AND Cold, cloudy weather ‘could increase your risk of having heart attack’ – The Guardian (free)

 

5 – Average Clinician‐Measured Blood Pressures and Cardiovascular Outcomes in Patients With Type 2 Diabetes Mellitus and Ischemic Heart Disease in the EXAMINE Trial – Journal of the American Heart Association (free)

Editorial: The Ongoing Saga of Optimal Blood Pressure Level in Patients With Diabetes Mellitus and Coronary Artery Disease (free)

“A U‐shaped relationship between cardiovascular outcomes and BPs was observed.”

 

6 – Association of Blood Pressure Measurements With Peripheral Artery Disease Events: Reanalysis of the ALLHAT Data – Circulation (free)

Editorial: New Curveball for Hypertension Guidelines? Blood Pressure Targets in Peripheral Artery Disease (free)

“we found a higher rate of lower extremity PAD events with higher and lower SBP and pulse pressure and with lower DBP.”

 

7 – Clinical Model to Predict 90-Day Risk of Readmission After Acute Myocardial Infarction: A Report From the National Cardiovascular Data Registry ACTION Registry – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Score predicts 90-day readmission risk after myocardial infarction – ACP Hospitalist (free) AND Novel risk predictor identifies likelihood of readmission after AMI – Cardiovascular Business (free)

 

8 – Review: Pulmonary Embolism: Contemporary Medical Management and Future Perspectives – Annals of Vascular Disease (free PDF)

 

9 – Canadian Urological Association guideline on male lower urinary tract symptoms/benign prostatic hyperplasia (MLUTS/BPH): 2018 update – Canadian Urological Association Journal (free)

Related Guideline: Surgical Management of Lower Urinary Tract Symptoms attributed to BPH (free guideline and commentary)

 

10 – Self-monitoring of blood glucose provides no important benefit for most people with type 2 diabetes – NIHR Signal (free)

Original Article: Self-monitoring blood glucose improves glycemic control in type 2 diabetes without intensive treatment: A systematic review and meta-analysis – Diabetes Research and Clinical Practice (link to abstract – $ for full-text)

 


 

1 – ACTIVE: A technical package for increasing physical activity – World Health Organization (free PDF)

News Release: WHO launches ACTIVE: a toolkit for countries to increase physical activity and reduce noncommunicable diseases (free)

 

2 – Screening for Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: US Preventive Services Task Force Final Recommendation Statement – JAMA (free)

Editorials: Challenges and Opportunities for Studying Routine Screening for Abuse (free) AND Addressing Intimate Partner Violence and Abuse of Older or Vulnerable Adults in the Health Care Setting—Beyond Screening (free)

 

3 – Efficacy and safety of cefazolin versus antistaphylococcal penicillins for the treatment of methicillin-susceptible Staphylococcus aureus bacteremia: a systematic review and meta-analysis – BMC Infectious Diseases (free)

 

4 – Perspective: Superfoods Are a Marketing Ploy – The Atlantic (free) (via @edyong209 and @onisillos)

 

5 – Perspective: The Problem With Probiotics – The New York Times (free)

Related: Probiotic Safety—No Guarantees (free perspective)

“There are potential harms as well as benefits, and a lot of wishful thinking and imprecision in the marketing of products containing them.”

 

6 – Perspective: The Price of Knowledge: Industry-Sponsored Studies in the Era of Evidence-Based Medicine – TCTMD (free)

 

7 – Deep neural network improves fracture detection by clinicians – Proceedings of the National Academy of Sciences (free)

“How to reduce emergency doctor misinterpretation of wrist X-rays for fracture by nearly 50%? Deep learning AI, of course” (via @EricTopol see Tweet)

 

8 – Association of Frequency of Organic Food Consumption With Cancer Risk: Findings From the NutriNet-Santé Prospective Cohort Study – JAMA Internal Medicine (free for a limited period)

Commentaries: Organic Foods for Cancer Prevention—Worth the Investment? – JAMA Internal Medicine (free for a limited period) AND Organic food and cancer – Science Media Centre (free) AND Organic foods tied to slightly lower cancer risk – Reuters (free)

 

9 – Atezolizumab and Nab-Paclitaxel in Advanced Triple-Negative Breast Cancer – New England Journal of Medicine (free for a limited period)

Commentaries: Not So Fast With Immune Therapy For Breast Cancer – Forbes (free) AND Immunotherapy drugs show some promise against breast cancer – STAT (free)

“…the benefit for most women was small, raising questions about whether the treatment is worth its high cost and side effects.” (from STAT)

 

10 – Diagnosis of Pulmonary Embolism During Pregnancy: A Multicenter Prospective Management Outcome Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Algorithm Rules Out Pulmonary Embolism in Pregnancy – NEJM Journal Watch (free) AND Algorithm Validated for Pulmonary Embolism Diagnosis in Pregnancy – MedPage Today (free registration required)

 


 

#LIVE2018 – Highlights from the European Society of Intensive Care Medicine Congress (via Critical Care Reviews)

 

 

1 – #LIVE2018 –  Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness – New England Journal of Medicine (free for a limited period)

Editorial: Dopamine Antagonists in ICU Delirium (free for a limited period)

Commentaries: Common use of antipsychotics shown ineffective for delirium in intensive care patients – NIH News Releases (free) AND Antipsychotic Drugs Don’t Ease ICU Delirium Or Dementia – NPR (free) AND Antipsychotics ineffective for treating ICU delirium – Vanderbilt University Medical Center (free)

Related Research: Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium (free)

 

2 – #LIVE2018 – Energy-Dense versus Routine Enteral Nutrition in the Critically Ill – New England Journal of Medicine (free for a limited period)

Energy-dense formulation for enteral delivery of nutrition was not associated with better outcomes.

 

3 – #LIVE2018 – Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit (free for a limited period)

Among patients receiving mechanical ventilation in ICUs with moderate to high ABX resistance prevalence, use of chlorhexidine mouthwash, selective oropharyngeal decontamination, or selective digestive tract decontamination was not associated with reductions in ICU-acquired bloodstream infections caused by MDRGNB vs standard care” (via @JAMA_current see Tweet with visual abstract)

 

4 – #LIVE2018 – Effect of Protocolized Weaning With Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Weaning From Mechanical VentilationWhat Should Be Done When a Patient’s Spontaneous Breathing Trial Fails? (free for a limited period)

Among patients requiring mechanical ventilation in whom a spontaneous breathing trial had failed, early extubation to noninvasive ventilation did not shorten time to liberation from any ventilation.”

 

5 – The Artificial Intelligence Clinician learns optimal treatment strategies for sepsis in intensive care – Nature Medicine (free link via Critical Care Reviews)

Commentaries: AI doctor could boost chance of survival for sepsis patients – Imperial College London (free) AND Artificial intelligence system could improve survival for sepsis patients – NHS National Institute for Health Research (free)

 

6 – Videos: Order Wisely®: Appropriate use of tests & treatments – High Value Practice Academic Alliance (free) (via @KariTikkinen)

Comprehensive educational program that reviews appropriate use of imaging exams, lab tests, medications, transfusions and procedures to promote high-value practice.

 

7 – Podcast: #121 HIV Care for the Internist – Curbsiders Internal Medicine Podcast (free audio and summary)

 

8 – Alex Nowbar’s research reviews—22 October 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 

9 – Want To Keep Your Brain Sharp? Take Care Of Your Eyes And Ears – NPR (free)

Related Articles: Longitudinal Relationship Between Hearing Aid Use and Cognitive Function in Older Americans – Journal of the American Geriatrics Society (free) AND Cataract surgery and age-related cognitive decline: A 13-year follow-up of the English Longitudinal Study of Ageing – NPR (free)

 

10 – Radiotherapy to the primary tumour for newly diagnosed, metastatic prostate cancer (STAMPEDE): a randomised controlled phase 3 trial – The Lancet (free)

Commentaries: Radiotherapy for newly diagnosed oligometastatic prostate cancer – The Lancet (free) AND ESMO 2018: Local radiotherapy improves survival in metastatic prostate cancer with low disease burden – eCancer News (free) AND Radiotherapy offers hopes in advanced prostate cancer – OnMedica (free) AND Cancer trial shows treating the prostate with radiotherapy improves survival – University of Birmingham (free)

 


 

1 – Effect of Theophylline as Adjunct to Inhaled Corticosteroids on Exacerbations in Patients With COPD: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: TWICS results suggest no role for low-dose theophylline as add-on therapy in COPD – Medwire News (free) AND Low-Dose Theophylline Not Effective at Reducing COPD Exacerbations, Study Finds – AJMC (free)

 

2 – Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis – Medicine (free)

 

3 – Association between patient outcomes and accreditation in US hospitals: observational study – The BMJ (free)

Commentaries: Joint Commission accreditation doesn’t lead to better outcomes, study shows – Modern Healthcare (free) AND Doubt cast on value of hospital accreditation in Harvard study – Healthcare Dive (free)

 

4 – The clinical and cost-effectiveness of corticosteroid injection versus night splints for carpal tunnel syndrome (INSTINCTS trial): an open-label, parallel group, randomised controlled trial – The Lancet (free)

Invited Commentary: Steroid injection or wrist splint for first-time carpal tunnel syndrome? (free)

“A single corticosteroid injection shows superior clinical effectiveness at 6 weeks compared with night-resting splints.”

 

5 – Talking about dying: How to begin honest conversations about what lies ahead – Royal College of Physicians (free)

News Release: New report asks why doctors find it so hard to talk to patients about dying (free)

Commentaries: Doctors must talk ‘honestly’ to patients about dying – OnMedica (free) AND Doctors ‘need to start early conversation with patients about dying’ – BBC (free)

 

6 – How early media exposure may affect cognitive function: A review of results from observations in humans and experiments in mice – Proceedings of the National Academy of Sciences (free)

Related Article: Screen media use and ADHD-related behaviors: Four decades of research – Proceedings of the National Academy of Sciences (free)

 

7 – Review: Eosinophilic Esophagitis: Review and Update – Frontiers in Medicine (free)

 

8 – 2019 Canadian guideline for physical activity throughout pregnancy – British Journal of Sports Medicine (free)

 

9 – Prokinetics for functional dyspepsia – Cochrane Library (free)

Summary: Medications which promote stomach movement to relieve upper abdominal discomfort that does not have a specific cause – Cochrane Library (free)

“We are unable to say whether prokinetics are effective for the treatment of functional dyspepsia.”

 

10 – Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing – JAMA Network Open (free)

Commentaries: Expansive New Study Says Not Exercising Is Worse for Your Health Than Smoking – TIME (free) AND Researchers show better cardiorespiratory fitness leads to longer life – MedicalXpress (free)

 


 

1 – Pre-eclampsia and risk of dementia later in life: nationwide cohort study – The BMJ (free)

Editorial: Pre-eclampsia and the brain (free)

Commentaries: Pre-eclampsia linked to raised risk of vascular dementia – OnMedica (free) AND Pre-eclampsia linked to an increased risk of dementia later in life – The BMJ (free)

 

2 – Perspective: To Prevent Cardiovascular Disease, Pay Attention to Pregnancy Complications – JAMA (free for a limited period)

Related: Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease (link to abstract and commentaries)

 

3 – Enhanced Recovery in Surgical Intensive Care: A Review – Frontiers in Medicine (free)

 

4 – Review: Newer technologies for detection of atrial fibrillation – The BMJ (free for a limited period)

 

5 – Effect of Cricoid Pressure Compared With a Sham Procedure in the Rapid Sequence Induction of Anesthesia: The IRIS Randomized Clinical Trial – JAMA Surgery (free for a limited period)

Commentaries: Is 30 Newtons of Prevention Worth a Pound of a Cure?—Cricoid Pressure – JAMA Surgery (free for a limited period) AND The Case of the Inferior Superiority – EMNerd (free)

 

6 – US FDA Breast Implant Postapproval Studies: Long-term Outcomes in 99,993 Patients – Annals of Surgery (free)

Commentary: Long-term safety of silicone breast implants still unclear – Reuters (free)

 

7 – See It, Want It, Buy It, Eat It – Cancer Research UK (free PDF)

Commentaries: Time spent by children online linked to requests for junk food – University of Liverpool (free) AND Does TV and internet advertising feed children’s junk food habits? – NHS Choices (free)

 

8 – Deep learning algorithms for detection of critical findings in head CT scans: a retrospective study – The Lancet (link to abstract – $ for full-text)

Commentary: AI: Deep Learning Algorithms Can Detect Critical Head CT Findings – MedicalResearch.com (free)

 

9 – Antidepressant withdrawal: reviewing the paper behind the headlines – The Mental Elf (free) (via @AllenFrancesMD)

Original Systematic Review: Antidepressant Withdrawal Effects (free article and commentaries)

“Last week a new review said: – Over half of people taking antidepressants experience withdrawal symptoms – These symptoms are severe in over half of cases. The press had a field day! Our blog today by @J_F_Hayes and @sameerjauhar offers a different view” (via @Mental_Elf see Tweet)

 

10 – Association of Aspirin With Prevention of Venous Thromboembolism in Patients After Total Knee Arthroplasty Compared With Other Anticoagulants: A Noninferiority Analysis – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: More Research Supports Use of Aspirin Alone to Prevent VTE After Knee Replacement Surgery – TCTMD (free) AND Aspirin Noninferior to Other Anticoagulants in Knee Arthroplasty – Journal Watch (free)

Related Randomized Trial: Aspirin Starting Five Days After Hip or Knee Arthroplasty for VTE Prophylaxis (link to abstract, video summary and commentary)

 


 

1 – Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016–40 for 195 countries and territories – The Lancet (free)

Commentaries: Major strides in forecasting future health – The Lancet (free) AND Why Life Expectancy in 2040 Could Be Lower Than It Is Today – LiveScience (free) AND How healthy will we be in 2040? – Institute for Health Metrics and Evaluation (free)

 

2 – Acute Flaccid Myelitis Investigation Page – Centers for Disease Control and Prevention (free)

Commentaries: CDC, partners probe 127 polio-like cases in 22 states – CIDRAP (free) AND CDC Investigates Cases Of Rare Neurological ‘Mystery Illness’ In Kids – NPR (free) AND Acute Flaccid Myelitis Cases Confirmed in 22 States Physician’s First Watch (free) AND CDC expresses concern over mysterious surge in polio-like paralysis cases – STAT (free)

 

3 – Survivorship, Version 2.2018, NCCN Clinical Practice Guidelines in Oncology – Journal of the National Comprehensive Cancer Network (free)

Related: Cardiovascular Toxicity in Cancer Survivors (free review and guidelines) AND Burden of cardiovascular risk factors and cardiovascular disease in childhood cancer survivors (link to abstract and commentaries) AND The cumulative burden of surviving childhood cancer (link to abstract and commentaries) AND Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood (free study and commentaries) AND Endocrine Disorders in Survivors of Childhood Cancer (free guideline and commentaries)

 

4 – Australia is responding to the complex challenge of overdiagnosis – The Medical Journal of Australia (free for 7 days)

Commentaries: Overdiagnosis: a deep cultural problem – MJA InSight (free) AND Overdiagnosis is harming patients and action is required, says chief medical officer – The Sidney Morning Herald (free)

Related: Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician (free) AND Overdiagnosis across medical disciplines: a scoping review – The BMJ Open (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free) AND Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free) AND Position Paper on Overdiagnosis and Action to be Taken – Wonca (free PDF)

 

5 – Podcast: #119 Nutrition Pearls, Heart Health, Bacon – Curbsiders Internal Medicine Podcast (free audio and summary)

 

6 – Sarcopenia: revised European consensus on definition and diagnosis – Age and Ageing (free)

 

7 – Position Statement: Guidelines for vitamin K prophylaxis in newborns: A joint statement of the Canadian Paediatric Society and the College of Family Physicians of Canada – Canadian Family Physician (free)

 

8 – Progestogen for preventing miscarriage in women with recurrent miscarriage of unclear etiology – Cochrane Library (free for a limited period)

Summary: Progestogen for preventing miscarriage – Cochrane Library (free)

 

9 – Deep Learning to Distinguish Recalled but Benign Mammography Images in Breast Cancer Screening – Clinical Cancer Research (free PDF)

Commentaries: Study Finds Deep Learning Can Distinguish Recalled-Benign Mammogram Images From Malignant and Negative Cases – The ASCO Post (free) AND AI distinguishes false-positive mammograms from malignant, negative mammograms – Radiology Business (free) AND Deep learning can distinguish recalled-benign mammograms from malignant and negative images – eCancer News (free)

 

10 – Hospital Readmission Following Takotsubo Syndrome – European Heart Journal – Quality of Care and Clinical Outcomes (link to abstract – $ for full-text)

Commentaries: Takotsubo Syndrome Linked to Heart Failure Admissions and Mortality Risk in Nationwide Study – TCTMD (free) AND Avoiding Broken-Heart Syndrome Readmissions – MedPage Today (free registration required)

Related: International Registry: Long-Term Prognosis of Patients With Takotsubo Syndrome (link to abstract and commentaries) International Expert Consensus Document on Takotsubo Syndrome (free guideline) AND Review: Takotsubo Syndrome (free reviews)

 


 

1 – Association Between Bariatric Surgery and Macrovascular Disease Outcomes in Patients With Type 2 Diabetes and Severe Obesity – JAMA (link to abstract – $ for full-text)

Video Summary: How Does Bariatric Surgery Compare With Medical Care for Reducing Cardiovascular Disease in Patients With Type 2 Diabetes? (free)

Commentary: Obesity surgery may lower heart attack danger in diabetics – Associated Press (free)

 

2 – Perspective: The New Age of Patient Autonomy: Implications for the Patient-Physician Relationship – JAMA (free for a limited period) (via @EricTopol)

 

3 – Perspective: What should we stop doing in the ICU? – ICU Management & Practice (free)

 

4 – Perspective: I hate guidelines (but they can improve and you can help) – First10Em (free) (via @srrezaie)

 

5 – Review: Treatments targeting inotropy – European Heart Journal (free)

 

6 – Review: Disseminated Intravascular Coagulation: An Update on Pathogenesis, Diagnosis, and Therapeutic Strategies – Clinical and Applied Thrombosis/Hemostasis (free)

Source: Critical Care Reviews Newsletter

 

7 – Researcher Requests for Inappropriate Analysis and Reporting: A U.S. Survey of Consulting Biostatisticians – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: When scientists want their data fudged and why you should care – CBC (free)

 

8 – Heart disease used to be an ailment of the rich. But it’s now striking the world’s poor. – VOX (free)

“In 2016, an estimated 1 million people died of HIV/AIDS, 445,000 people died of malaria, and 1.7 million died of tuberculosis. Nearly 18 million died of heart disease. And more than three-quarters of those deaths occurred in the developing world.”

 

9 – Calcium supplementation during pregnancy for preventing hypertensive disorders and related problems – Cochrane Library (free for a limited period)

Summary: Calcium supplementation during pregnancy for preventing blood pressure disorders and related problems – Cochrane Library (free)

 

10 – Early clindamycin for bacterial vaginosis in pregnancy (PREMEVA): a multicentre, double-blind, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Study: Antibiotics for bacterial vaginosis don’t cut preterm birth risk – CIDRAP (free)

 


 

1 – Attention deficit hyperactivity disorder late birthdate effect common in both high and low prescribing international jurisdictions: systematic review – The Journal of Child Psychology and Psychiatry (free)

Commentary: Global study finds youngest in class more likely to be diagnosed with ADHD – University of Adelaide (free)

“Youngest kids in class much more likely get ADHD diagnosis than oldest. Bad News: Simple immaturity now turned into mental illness & treated with meds” (via @AllenFrancesMD see Tweet)

 

2 – Many Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results – Advances in Methods and Practices in Psychological Science (free) (via @f_g_zampieri)

“This is one of most important studies published this century. 29 teams used same data set to address same research question; estimated effect sizes ranged from 0.89 to 2.93 in odds-ratio units. Dramatic implications for observational research.” (via @hmkyale see Tweet)

 

3 – WHO Statement: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: DR Congo: managing Ebola virus in war – The Lancet (free) AND Ebola experts from CDC were pulled from outbreak zone amid security concern – STAT (free) AND Ebola showed up in a war zone. It’s not going well – VOX (free) AND Experts Said A War Zone Ebola Outbreak Would Be A Nightmare. It’s Been Even Worse – HuffPost (free) AND DRC Ebola cases top 200 as security problems fuel the spike – CIDRAP (free)

 

4 – A pandemic killing tens of millions of people is a real possibility — and we are not prepared for it – VOX (free)

Related: Innovation for Pandemics (free perspectives and video on the subject)

 

5 – Ann Robinson’s research reviews, 15 October 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 

6 – Demystifying serotonin syndrome (or serotonin toxicity) – Canadian Family Physician (free)

 

7 – Approach to the detection and management of chronic kidney disease: What primary care providers need to know – Canadian Family Physician (free)

 

8 – Oliguria in critically ill patients: a narrative review – Journal of Nephrology (free)

Source: Critical Care Reviews Newsletter

 

9 – β-Blocker Use in Pregnancy and the Risk for Congenital Malformations: An International Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Beta-Blocker Use in First Trimester Seems Safe – Physician’s First Watch (free) AND Beta-blocker Use in Pregnancy Doesn’t Up Birth Defect Risk, Study Suggests – TCTMD (free)

 

10 – Identity inference of genomic data using long-range familial searches – Science (free for a limited period)

Commentaries: Most White Americans’ DNA Can Be Identified Through Genealogy Databases – The New York Times (10 articles per month are free) AND How an Unlikely Family History Website Transformed Cold Case Investigations – The New York Times (10 articles per month are free) AND ‘We are increasingly exposed’: New studies show how easy it is to identify people using genetic databases – STAT (free) AND Supercharged crime-scene DNA analysis sparks privacy concerns – Nature (free)

 


 

1 – WHO recommendations: non-clinical interventions to reduce unnecessary caesarean sections – World Health Organization (free PDF)

News Release: New WHO guidance on non-clinical interventions specifically designed to reduce unnecessary caesarean sections (free)

Related Cochrane Review: Non‐clinical interventions for reducing unnecessary caesarean section (free review and summary)

 

2 – Series: Optimising caesarean section use – The Lancet (free articles and commentaries, registration required)

Commentaries: Caesarean section use has almost doubled globally since 2000 – The Lancet (free) AND C-section births rise rapidly to more than 20 percent worldwide – Reuters (free) AND Rate Of C-Sections Is Rising At An ‘Alarming’ Rate, Report Says – NPR (free) AND C-section deliveries nearly doubled worldwide since 2000, study finds – CNN (free) AND C-section births surge to ‘alarming’ rates worldwide – study – BBC (free)

 

3 – A blueprint for the primary prevention of cancer: Targeting established, modifiable risk factors – CA: A Cancer Journal for Clinicians (free)

Commentary: Comprehensive report says tobacco control must be highest priority in cancer control – American Cancer Society (free)

 

4 – Analysis: Treatment burden should be included in clinical practice guidelines – The BMJ (free for a limited period)

 

5 – Opinion: Professional Societies Should Abstain From Authorship of Guidelines and Disease Definition Statements – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Professional Societies, Clinical Specialists, and Guidelines – Circulation: Cardiovascular Quality and Outcomes (free) AND Turn Cardiology Guidelines Over to Outsiders – MedPage Today (free registration required)

John Ioannidis, MD. “questioned whether cardiovascular guidelines “homogenize biased, collective, and organized ignorance” through use of predominantly “insider” experts as authors.” (from MedPage Today)

 

6 – Diagnosis and management of non-dialysis chronic kidney disease in ambulatory care: a systematic review of clinical practice guidelines – BMC Nephrology (free)

 

7 – KAAACI Evidence-Based Clinical Practice Guidelines for Chronic Cough in Adults and Children in Korea – Allergy, Asthma & Immunology Research (free)

Related: Managing Patients with Chronic Cough (free CHEST guidelines on the subject)

 

8 – Supplement: Digital Health and Health Systems of the Future – Global Health: Science and Practice (free articles)

Source: International Health Policies Newsletter

 

9 – Association of Mechanical Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery With Surgical Site Infection: A Network Meta-analysis – JAMA Network Open (free)

Invited Commentary: When Will the Surgical Community Acknowledge the Evidence Regarding Prophylaxis With Oral Antibiotics for Scheduled Colorectal Operations? (free)

Bowel Preparation and Oral Antibiotics Before Elective Colorectal Surgery. Once again the combination of oral antibiotic and oral mechanical cathartic bowel preparation yields the lowest rates of surgical site infections” (via @SWexner see Tweet)

 

10 – Unapproved Pharmaceutical Ingredients Included in Dietary Supplements Associated With US Food and Drug Administration Warnings – JAMA Network Open (free)

Editorial: The FDA and Adulterated Supplements—Dereliction of Duty – JAMA Network Open (free)

Commentaries: Nearly 800 dietary supplements contained unapproved drug ingredients, study finds – CNN (free) AND No Wonder It Works So Well – NPR (free) AND Hundreds of Dietary Supplements Are Tainted with Prescription Drugs – Scientific American (free) AND Hundreds of health, weight loss products contain unapproved ingredients: Study – UPI (free) AND Some dietary supplements contain potentially harmful drugs – Reuters (free)

 


 

1 – Review: What treatments are effective for common cold in adults and children? – The BMJ (free review and infographic)

Commentaries: What works for treating children’s colds? – BBC (free) AND Doctors should steer young children away from decongestants – OnMedica (free)

 

2 – How To Prevent Brain-Sapping Delirium In The ICU – NPR (free text and podcast)

Related: ABCDEF Bundle – Society of Critical Care Medicine (free resource) AND The ABCDEF Bundle: Science and Philosophy of How ICU Liberation Serves Patients and Families – Critical Care Medicine (free)

 

3 – Correspondence: Real-Time Patient–Provider Video Telemedicine Integrated with Clinical Care – New England Journal of Medicine (free)

 

4 – Perspective: The approach to predictive medicine that is taking genomics research by storm – Nature (free)

“Polygenic risk scores represent a giant leap for gene-based diagnostic tests. Here’s why they’re still so controversial.”

 

5 – Review: Venous thromboembolism prophylaxis may cause more harm than benefit: an evidence-based analysis of Canadian and international guidelines – Thrombosis Journal (free) (via @amtejani)

 

6 – Review: A New Vaccine for Shingles – Therapeutics Initiative (free)

“Need to vaccinate 31 people to prevent one instance of HZ; Need to vaccinate 358 people to prevent one instance on post herpetic neuralgia” (via @amtejani)

 

7 – Environmental Noise Guidelines for the European Region (2018) – World Health Organization (free PDF)

Commentary: Noise: The other pollution hurting our health – CNN (free)

 

8 – Clinical management of cutaneous adverse events in patients on targeted anticancer therapies and immunotherapies: a national consensus statement by the Spanish Academy of Dermatology and Venereology and the Spanish Society of Medical Oncology – Clinical and Translational Oncology (free)

 

9 – Effectiveness of the Stand More AT (SMArT) Work intervention: cluster randomised controlled trial – The BMJ (free)

Editorial: Reducing sedentary behaviour in the workplace (free)

Commentaries: Standing-desk workers ‘less tired, more engaged’ – BBC (free) AND Sit-stand desks may improve job performance, psychological health – UPI (free)

 

10 – Association of Unrecognized Myocardial Infarction With Long-term Outcomes in Community-Dwelling Older Adults: The ICELAND MI Study – JAMA (free for a limited period)

Commentaries: Silent Infarcts Have Similar Mortality Over 10 Years as Clinically Recognized MI – TCTMD (free) AND Association of Unrecognized MI With Long-Term Outcomes – American College of Cardiology (free)

Related Study: Silent Myocardial Infarction and Long-Term Risk of Heart Failure (link to abstract and commentaries)

 


 

1 – The Lancet Commission on global mental health and sustainable development (free registration required)

Commentaries: Mental health crisis could cost the world $16 trillion by 2030 – Reuters (free) AND Mental health disorders will cause ‘monumental suffering’ and cost £12 TRILLION a year worldwide by 2030 – The Daily Mail (free) AND World in mental health crisis of ‘monumental suffering’, say experts – The Guardian (free)

 

2 – Canadian Cardiovascular Harmonized National Guidelines Endeavour (C-CHANGE) guideline for the prevention and management of cardiovascular disease in primary care: 2018 update – Canadian Medical Association Journal (free)

 

3 – Timing of Renal-Replacement Therapy in Patients with Acute Kidney Injury and Sepsis – New England Journal of Medicine (link to abstract – $ for full-text)

Video Summary: Renal-Replacement Therapy for AKI (free)

Commentary: Is Kidney Dialysis Always Needed When Septic Shock Strikes? – HealthDay (free)

“Trial comparing early vs. delayed strategies of renal-replacement therapy in patients with early-stage septic shock who had severe acute kidney injury finds no significant between-group difference in overall mortality at 90 days.” (via @NEJM see Tweet)

 

4 – Effect of Immediate vs Delayed Pushing on Rates of Spontaneous Vaginal Delivery Among Nulliparous Women Receiving Neuraxial Analgesia: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Immediate vs Delayed Pushing During Second Stage of Labor (free)

Commentaries: When Giving Birth For The First Time, Push Away – NPR (free) AND In childbirth, when to begin pushing does not affect C-section rates – Washington University in St. Louis (free) AND Vaginal delivery not affected by delayed pushing, study says – UPI (free)

 

5 – Review: Management of severe acute exacerbations of COPD: an updated narrative review – Multidisciplinary Respiratory Medicine (free)

 

6 – Review: An update on the use of inhaled therapy in COPD – Clinical Medicine (free)

 

7 – Review: What is the significance of monoclonal gammopathy of undetermined significance? – Clinical Medicine (free)

 

8 – Ghost authorship haunts industry-funded clinical trials – Nature (free)

Original Article: Collaboration Between Academics and Industry in Clinical Trials (free study and commentaries)

 

9 – Evaluation of the diet wide contribution to serum urate levels: meta-analysis of population based cohorts – The BMJ (free)

Editorial: The role of diet in serum urate concentration (free)

Commentary: Diet Might Play Less of a Role in Gout Than Previously Thought – Physician’s First Watch (free)

 

10 – Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin – BMJ Case Reports (free)

Commentaries: Planned intermittent fasting may help reverse type 2 diabetes, suggest doctors – BMJ (free) AND Therapeutic Fasting Could Be an Alternative to Insulin for Some Diabetes Patients – Physician’s First Watch (free)

 


 

1 – Cluster Randomized Clinical Trial of FAITH (Faith-Based Approaches in the Treatment of Hypertension) in Blacks – Circulation: Cardiovascular Quality and Outcomes (free)

Editorial: Of Barbershops and Churches: Can Community-Based Interventions Improve Cardiovascular Risk in High-Risk Patients? (free)

Commentaries: Faith-based approach to changing lifestyle lowers blood pressure – AHA Newsroom (free) AND How church communities can help lower African-Americans’ blood pressure – CNN (free) AND Church-Based Lifestyle Intervention Shows Promise for Lowering BP in Hypertensive African-Americans – TCTMD (free)

Related Study: Cluster-Randomized Trial of Blood-Pressure Reduction in Black Barbershops (free study and commentaries)

 

2 – Fluoroquinolone and quinolone antibiotics: PRAC recommends new restrictions on use following review of disabling and potentially long-lasting side effects – European Medicines Agency (free)

Commentaries: EMA committee recommends restrictions on fluoroquinolone, quinolone antibiotics – Reuters (free) AND PRAC Recommends Restrictions on Fluoroquinolone, Quinolones – Medscape (free registration required)

Related FDA Safety Alert: Warnings for Fluoroquinolones on Risks of Mental Health and Low Blood Sugar Adverse Reactions (free statement and commentaries)

 

3 – Evidence synthesis for health policy and systems: a methods guide – World Health Organization (free PDF) (via @trishgreenhalgh)

 

4 – Non-celiac gluten/wheat sensitivity (NCGS)—a currently undefined disorder without validated diagnostic criteria and of unknown prevalence – Position statement of the task force on food allergy of the German Society of Allergology and Clinical Immunology (DGAKI) (free)

 

5 – Review: Managing the Patient with Heart Failure in the Emergency Department – European Heart Journal (free) (via @gonzaeperez)

 

6 – Review: Office approach to small fiber neuropathy – Cleveland Clinic Journal of Medicine (free)

 

7 – Review: Bicuspid aortic valve: Basics and beyond – Cleveland Clinic Journal of Medicine (free)

 

8 – Nine ways research could save the NHS money – NHS Dissemination Centre (free)

New infographic series with selected NIHR Signals covering a range of treatments and initiatives that are cost effective.

 

9 – 800,000 people kill themselves every year. What can we do? – The Guardian (free) (via @onisillos)

Related Guidelines: Preventing suicide: A community engagement toolkit – World Health Organization (free PDF) AND Preventing suicide in community and custodial settings – National Institute for Health and Care Excellence (free)

“In too many places mental health support services are non-existent and those with treatable conditions are criminalized. Bold action is long overdue”

 

10 – Electronic cigarette explosion and burn injuries, US Emergency Departments 2015–2017 – Tobacco Control (link to abstract – $ for full-text)

Commentaries: E-cigarette explosion and burn injuries have been underestimated by federal agencies – George Mason University (free) AND Study: E-Cigarette Injuries Drastically Underestimated – MedPage Today (free registration required)

 


 

1 – Level 3 guideline on the treatment of patients with severe/multiple injuries – German Trauma Society (free)

News Release: The updated German “Polytrauma – Guideline”: an extensive literature evaluation and treatment recommendation for the care of the critically injured patient (free)

Source: Critical Care Reviews Newsletter

 

2 – ESPEN guideline on clinical nutrition in the intensive care unit – Clinical Nutrition (free)

Source: Critical Care Reviews Newsletter

 

3 – Non‐clinical interventions for reducing unnecessary caesarean section – Cochrane Library (free for a limited period)

Summary: Non-clinical interventions for reducing unnecessary caesarean section (free)

 

4 – Pelvic floor muscle training versus no treatment, or inactive control treatments, for urinary incontinence in women – Cochrane Library (free)

Based on the data available, we can be confident that pelvic floor muscle training can cure or improve symptoms of stress urinary incontinence and all other types of urinary incontinence”

 

5 – Perspective: The Name of the Dog – New England Journal of Medicine (free)

“During morning rounds, I had presented a patient who was admitted for chest pain after walking his dog. My attending had asked, ‘What was the name of his dog?’ ” (via @fischmd see Tweet)

 

6 – Zackary Berger’s journal reviews, 8 October 2018 – The BMJ Opinion (free)

Zackary Berger reviews the latest research from the top medical journals.

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: September 2018 – eCancer News (free)

 

8 – Genomic Risk Prediction of Coronary Artery Disease in 480,000 Adults: Implications for Primary Prevention (via @EricTopol)

 

9 – Laparoscopic cholecystectomy versus percutaneous catheter drainage for acute cholecystitis in high risk patients (CHOCOLATE): multicentre randomised clinical trial – The BMJ (free)

“Laparoscopic cholecystectomy compared with percutaneous catheter drainage reduced the rate of major complications in high risk patients with acute cholecystitis.”

 

10 – Statins and Multiple Noncardiovascular Outcomes: Umbrella Review of Meta-analyses of Observational Studies and Randomized Controlled Trials – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Statin Benefits: Yes for CVD but No for Everything Else, Says New Review – TCTMD (free) AND Statins’ benefits beyond heart health aren’t clear-cut, analysis says – CNN (free)

 


 

1 – Management of Hyperglycemia in Type 2 Diabetes, 2018. A Consensus Report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) – Diabetes Care (free PDF)

Commentaries: New Consensus Report from the American Diabetes Association® (ADA) and the European Association for the Study of Diabetes (EASD) Calls for Paradigm Shift to Patient-Centered Care for Type 2 Diabetes – American Diabetes Association (free) AND New EASD-ADA consensus guidelines on managing hyperglycaemia in type 2 diabetes launched at EASD meeting – Diabetologia (free)

Related Guidelines: WHO Guideline: Medicines for the Treatment of Diabetes in Low-Resource Settings (free guideline and commentaries) AND Pharmacologic Glycemic Management of Type 2 Diabetes in Adults – Canadian Journal of Diabetes (free) AND ADA 2018 Standards of Medical Care in Diabetes (free guideline and commentaries) AND ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes (free guideline and commentaries)

 

2 – Supplement: ESMO Updated Clinical Practice Guidelines – European Society of Medical Oncology (free)

 

3 – Perspective: What the tests don’t show – The Washington Post (a few articles per month are free)

“Many doctors are surprisingly bad at reading test results and/or fail to grasp how false positives work. This is putting patients at risk” (via @pash22 see Tweet)

 

4 – Perspective: Why Employers Should Stop Giving Away Snacks – Pacific Standart (free)

Source: Global Health NOW Newsletter

 

5 – Outpatient antibiotics widely prescribed without an infection diagnosis – CIDRAP (free)

Related Commentary: Study Finds Almost Half of Antibiotic Prescriptions Written Without a Diagnosis – Pharmacy Times (free)

 

6 – Review: The Diagnosis and Treatment of Anxiety Disorders – Deutsches Ärzteblatt international (free)

 

7 – Review: Cardiovascular disease and COPD: dangerous liaisons? – European Respiratory Review (free)

 

8 – COPD Guidelines: A Review of the 2018 GOLD Report – Mayo Clinic Proceedings (free)

Related: Highlights from the New GOLD COPD Guidelines (free guideline and commentaries)

 

9 – Closed-loop insulin delivery in suboptimally controlled type 1 diabetes: a multicentre, 12-week randomised trial – The Lancet (free)

Commentaries: Enlarging the loop: closed-loop insulin delivery for type 1 diabetes – The Lancet (free) AND Hybrid Closed Loop System Aid for Tighter Glucose Control – MedPage Today (free registration required)

 

10 – Effectiveness of Online vs In-Person Care for Adults With Psoriasis: A Randomized Clinical Trial – JAMA Network Open (free)

Commentary: Treating psoriasis in the future could be as easy as going online – USC News (free)

 


 

1 – Acceleration of BMI in Early Childhood and Risk of Sustained Obesity – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Childhood BMI Acceleration and Sustained Obesity (free)

Commentary: BMI in Early Childhood and Sustained Obesity – American College of Cardiology (free)

 

2 – Effects of vitamin D supplementation on musculoskeletal health: a systematic review, meta-analysis, and trial sequential analysis – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentaries: The Lancet Diabetes & Endocrinology: Vitamin D supplementation in adults does not prevent fractures, falls or improve bone mineral density – The Lancet (free) AND Vitamin D supplements don’t help bone health, major study concludes – The Guardian (free) AND Millions of Americans take vitamin D. Most should just stop – VOX (free)

Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline) AND Vitamin D Not Linked to Fracture Risk (free study and commentaries)

 

3 – Clinical Update: Immune Checkpoint Inhibitor Toxicity in 2018 – JAMA (free for a limited period)

Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 

4 – Perspective: Given Their Potential for Harm, It’s Time to Focus on the Safety of Supplements – JAMA (free) (via @NUNESDOC)

“About 23 000 visits to emergency departments each year can be attributed to adverse events from dietary supplements.”

 

5 – Perspective: When Conventional Wisdom Is Put on Trial – UNDark (free) (via @EricTopol)

“The author of “Randomistas” shows how randomized trials have overturned many popular findings, from hormone therapy to the benefits of multivitamins.”

 

6 – Report: The future of healthcare – The Economist (free PDF)

 

7 – Effect of lorcaserin on prevention and remission of type 2 diabetes in overweight and obese patients (CAMELLIA-TIMI 61): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Weight loss drug shows positive effect on diabetes – Brigham and Women’s Hospital (free) AND Weight Loss Drug Helped Prevent Diabetes in Overweight People – MedPage Today (free registration required)

Related Article: Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients (link to abstract and commentaries)

 

8 – Collaboration between academics and industry in clinical trials: cross sectional study of publications and survey of lead academic authors – The BMJ (free)

Commentaries: Shining a light on industry collaboration – The BMJ Opinion (free) AND Industry funders involved in most aspects of funded trials – OnMedica (free)

 

9 – Perspective: New Tools in the Ebola Arsenal – New England Journal of Medicine (free)

Related: DRC Ebola cases rise as security concerns continue – CIDRAP (free) AND Officials fear Ebola epidemic may be spinning beyond their control, threatening regional spread – STAT (free) AND Ebola Likely to Spread From Congo to Uganda, W.H.O. Says – The New York Times (10 articles per month are free)

 

10 – Prescribed Exercise With Compression vs Compression Alone in Treating Patients With Venous Leg Ulcers: A Systematic Review and Meta-analysis – JAMA Dermatology (link to abstract – $ for full-text)

Commentaries: Adding Exercise to Compression Improves Outcomes in Venous Leg Ulcers – Physcian’s First Watch (free) AND Compressions May Remedy Venous Leg Ulcers – MedPage Today (free)

 


 

1 – NICE Guideline: Renal replacement therapy and conservative management – National Institute for Health and Care Excellence (free)

 

2 – The projected timeframe until cervical cancer elimination in Australia: a modelling study – The Lancet Public Health (free)

Commentaries: Modelling cervical cancer elimination – The Lancet Public Health (free) AND Australia on track to wipe out cervical cancer within 20 years – The Guardian (free) AND In Australia, Cervical Cancer Could Soon Be Eliminated – The New York Times (10 articles per month are free)

 

3 – Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: The burden of Parkinson’s disease: a worldwide perspective (free)

“In 2016, 6·1 million people worldwide had Parkinson’s disease, 2·9 million (48%) women & 3·2 million (52%) men; the increase in burden since 1990 was not exclusively explained by an increasing number of older people” (via @TheLancet see Tweet)

 

4 – Guidelines for Perioperative Care in Esophagectomy: Enhanced Recovery After Surgery (ERAS®) Society Recommendations – World Journal of Surgery (free for a limited period)

 

5 – Recommendations for the use of Electrophysiological Study: Update 2018 – Helenic Journal of Cardiology (free)

 

6 – Congenital Adrenal Hyperplasia Due to Steroid 21-Hydroxylase Deficiency: An Endocrine Society Clinical Practice Guideline – Journal of Clinical Endocrinology and Metabolism (free PDF)

News Release: Managing congenital adrenal hyperplasia requires shared decisions among patients, families, and heal – The Endocrine Society (free)

 

7 – Evaluating Progression-Free Survival as a Surrogate Outcome for Health-Related Quality of Life in Oncology: A Systematic Review and Quantitative Analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Health-related quality of life overlooked in cancer drug studies – McMaster University (free) AND Investigators Question the Use of PFS as a Surrogate End Point – Cancer Therapy Advisor (free) AND Preventing tumor spread may not improve quality of life – Reuters (free) AND Research: Consider quality of life when evaluating cancer drug studies – UPI (free)

 

8 – Committee Opinion: Well-Woman Visit – American College of Obstetrics and Gynecology (free)

News Release: ACOG and WPSI Release Materials to Support Women’s Preventive Care at Every Life Stage (free)

Commentary: ACOG Stresses Role of Ob/Gyns in Preventive Care For Women – Medscape (free registration required)

 

9 – Two antiplatelet drugs may prevent further strokes but increase major bleeds – NIHR Signal (free)

Original Article: Clopidogrel and Aspirin in Acute Ischemic Stroke and High-Risk TIA – New England Journal of Medicine (link to abstract – $ for full-text)

 

10 – A Population-Based Analysis of the Relationship Between Substance Use and Adolescent Cognitive Development – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Teen cannabis use is not without risk to cognitive development – Université de Montréal (free) AND Cannabis ‘more harmful than alcohol’ for teen brains – BBC (free)

 


 

1 – Ten Principles for More Conservative, Care-Full Diagnosis – Annals of Internal Medicine (free) (via @EricTopol)

 

2 – Management of Malignant Pleural Effusions. An Official ATS/STS/STR Clinical Practice Guideline – American Journal of Respiratory and Critical Care Medicine (free)

Related Guideline: ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)

 

3 – Effect of Early Surgery vs Physical Therapy on Knee Function Among Patients With Nonobstructive Meniscal Tears: The ESCAPE Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: PT an Alternative to Surgery for Some Meniscal Tears – Physician’s First Watch (free)

Related: Adverse Outcomes After Arthroscopic Partial Meniscectomy (free study, commentary and guideline on the subject)

 “Our Dutch multi center RCT demonstrates noninferiority of physical therapy compared with early surgery with arthroscopic partial meniscectomy for improving self-reported knee function in patients with nonobstructive meniscal tears.” (via @RudolfPoolman see Tweet)

 

4 – Association of Thyroid Hormone Therapy With Quality of Life and Thyroid-Related Symptoms in Patients With Subclinical Hypothyroidism: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: Most Patients With Subclinical Hypothyroidism May Not Require Thyroid Medication – MedicalResearch.com (free) AND Hormone Tx May Not Benefit Subclinical Hypothyroidism – MedPage Today (free registration required) AND Treating Subclinical Hypothyroidism Is of Little Benefit – Medscape (free registration required)

 

5 – A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)

Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)

Related: Antidepressant Withdrawal Syndrome (free review and NYT article)

 

6 – Association is not causation: treatment effects cannot be estimated from observational data in heart failure – European Heart Journal (free)

 

7 – Fracture Prevention with Zoledronate in Older Women with Osteopenia – New England Journal of Medicine (free)

Editorial: A Not-So-New Treatment for Old Bones (free)

Commentary: Study Suggests More Older Women May Benefit From Bone Drugs – The Associated Press (free)

 

8 – Review: Neuro-Ophthalmology at the bedside: A clinical guide – Journal of Neurosciences in Rural Practice (free)

 

9 – Efficacy of Low-Dose Amitriptyline for Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Low-dose antidepressants ease back pain – Australian Hospital + Healthcare Bulletin (free) AND Antidepressant Amitriptyline Might Help Ease Low Back Pain – Physician’s First Watch (free)

 

10 – Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial – The BMJ (free)

Related Research: 6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (link to abstract and commentaries)

In this study, DAPT for 6 months was non-inferior to DAPT for 12 months after drug-eluting stent implantation in ST-elevation myocardial infarction.

 


 

1 – WHO launches SAFER alcohol control initiative to prevent and reduce alcohol-related death and disability – World Health Organization (free)

See also: SAFER High Impact Strategies (free)

Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries)

 

2 – Guideline: Placenta Praevia and Placenta Accreta: Diagnosis and Management – British Journal of Obstetrics and Gynaecology (free)

 

3 – Guideline: Vasa Praevia: Diagnosis and Management – British Journal of Obstetrics and Gynaecology (free)

 

4 – Video: KHN Conversation on Overtreatment – Kaiser Health News (free)

Commentary: Changing Healthcare’s Culture of Overtreatment a Challenge – MedPage Today (free registration required)

Related KHN Series: Treatment Overkill (free articles)

 

5 – WCLC 2018: NELSON Study: CT Screening for Early Lung Cancer Reduces Lung Cancer Mortality – The ASCO Post (free)

Related: NELSON lung cancer study encourages widespread screening, Medicare reimbursement – Health Imaging (free) AND Second Large Study Shows That Lung Cancer Screening Works – Medscape (free registration required)

 

6 – Perspective: More Evidence That Nutrition Studies Don’t Always Add Up – The New York Times (10 articles per month are free)

 

7 – Podcast: #116 Geriatric Psychiatry: Sleep, Dementia, and Behavioral Disturbances – Curbsiders Internal Medicine Podcast (free)

Related Podcast: #115 Geriatric Depression – The Curbsiders Internal Medicine Podcast (free)

 

8 – Effects of Coenzyme Q10 on Statin‐Induced Myopathy: An Updated Meta‐Analysis of Randomized Controlled Trials – Journal of the American Heart Association (free)

Commentary: Coenzyme Q10 reduces statin-induced myopathy symptoms – Univadis (free registration required)

 

9 – Prediction of Susceptibility to First-Line Tuberculosis Drugs by DNA Sequencing – New England Journal of Medicine (free)

Editorial: The Coming of Age of Drug-Susceptibility Testing for Tuberculosis (free)

Commentaries: Study heralds genetic era of TB drug susceptibility testing – CIDRAP (free) AND UK-led study marks shift towards genetic era in tackling TB – NIHR Oxford Biomedical Research Centre (free)

 

10 – 2018 IDSA Guidelines for Clostridium Difficile Infection: fecal transplant gets its moment in the sun – PulmCCM (free)

Related Guidelines: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free) AND The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines – GUT (free)

 


 

1 – Press Release: The Nobel Prize in Physiology or Medicine 2018 – The Nobel Prize (free)

Commentaries: Cancer immunologists scoop medicine Nobel prize – Nature (free) AND Nobel Prize in medicine awarded to two cancer researchers for immune system breakthrough – STAT (free) AND 2018 Nobel Prize in Medicine Awarded to 2 Cancer Immunotherapy Researchers – The New York Times (10 articles per month are free)

 

2 – Effect of Increased Daily Water Intake in Premenopausal Women With Recurrent Urinary Tract Infections: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Editorial: Drinking More Water for Prevention of Recurrent Cystitis (free)

Commentaries: Drinking more water reduces bladder infections in women – UT Southwestern Medical Center (free) AND Drinking more water linked to fewer bladder infections in women – UPI (free)

 

3 – Report: Taking action on childhood obesity report – World Health Organization (free PDF) (via @equitylist)

 

4 – Supplement: Practical guide for allergy and immunology in Canada 2018 – Allergy, Asthma & Clinical Immunology (free reviews)

– Homepage

– Introduction from the Editors

– An introduction to immunology and immunopathology

– Asthma

– Allergic rhinitis

– Atopic dermatitis

– Allergen-specific immunotherapy

– Anaphylaxis

– IgE-mediated food allergy

– Non-IgE-mediated food hypersensitivity

– Early introduction of foods to prevent food allergy

– Eosinophilic esophagitis

– Urticaria and angioedema

– Drug allergy

– Primary immunodeficiency

 

5 – Perspective: Failing the Public Health — Rofecoxib, Merck, and the FDA – New England Journal of Medicine (free)

 

6 – Zackary Berger’s journal reviews, 1 October 2018 – The BMJ Opinion (free)

 

7 – Standards for Neurologic Critical Care Units: A Statement for Healthcare Professionals from The Neurocritical Care Society – Neurocritical Care (free)

Source: Critical Care Reviews Newsletter

 

8 – Review: Pulmonary vasculitis – Journal of Thoracic Disease (free)

Source: Critical Care Reviews Newsletter

 

9 – Over 80,000 Americans Died of Flu Last Winter, Highest Toll in Years – The New York Times (10 articles per month are free)

Related: 80,000 people died of flu last winter in US – Associated Press (free)

 

10 – Language Experience in the Second Year of Life and Language Outcomes in Late Childhood – Pediatrics (free)

Commentaries: Early Language Exposure and Middle School Language and IQ: Implications for Primary Prevention – Pediatrics (free) AND Conversations Between Parents and Toddlers Help Build Intelligence and Vocabulary – Journal Watch (free)

 


 

1 – Editorial: We Know How to Conquer Tuberculosis – The New York Times (10 articles per month are free)

Related: Tuberculosis experts hail historic week in the fight against TB – London School of Hygiene & Tropical Medicine (free) AND You Can’t Treat Tuberculosis With Platitudes – Foreign Policies (a few articles are free) AND Tuberculosis is a disease the world could control. But will it? – STAT (free) AND Addressing the Tuberculosis Epidemic: 21st Century Research for an Ancient Disease – JAMA (free)

 

2 – Potential effect of household contact management on childhood tuberculosis: a mathematical modelling study – The Lancet Global Health (free)

Invited Commentary: Preventing tuberculosis in household contacts crucial to protect children and contain epidemic spread (free)

Related: New roadmap to prevent and treat tuberculosis in children and adolescents – UNICEF (free)

 

3 – Doctor Referral of Overweight People to Low Energy total diet replacement Treatment (DROPLET): pragmatic randomised controlled trial – The BMJ (free)

Commentaries: Susan Jebb: Interventions to treat obesity work—so why am I not celebrating? – The BMJ Opinion (free) AND Expert reaction to study looking at total diet replacement programmes and obesity – Science Media Centre (free) AND Crash diets are highly effective – new evidence – The Conversation (free)

 

4 – Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentaries: Limiting children’s recreational screen time to less than 2 hours a day linked to better cognition – The Lancet (free) AND Limiting children’s screen time linked to better cognition, study says – CNN (free) AND Limiting children’s screen time linked to better cognition – BBC (free)

“Researchers said more work was now needed to better understand the effects of different types of screen use. However, they acknowledge that their observational study shows only an association between screen time and cognition and cannot prove a causal link.” (from BBC)

 

5 – Association of Same-Day Discharge After Elective Percutaneous Coronary Intervention in the United States With Costs and Outcomes – JAMA Network Open (free)

“Same day discharge after elective PCI used infrequently (3.5%), while safe + associated w/ reduced costs” (via @krychtiukmd see Tweet)

 

6 – Video: Understanding How Machine Learning Works – JAMA (free)

 

7 – Deprescribing recommendations: An essential consideration for clinical guideline developers – Research in Social and Administrative Pharmacy (free)

Related: Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

““Clinical guidelines often do not accommodate frailty or patients with multiple comorbid conditions. This can give rise to complex medication regimens and risk of medication harm. “Paper discusses the need to include deprescribing in clinical guidelines” (via @Deprescribing see Tweet)

 

8 – Opinion: No more first authors, no more last authors – Nature (free)

“The controversial suggestion that we “blow up” authorship conventions to foster team, collaborative science” (via @EricTopol see Tweet)

 

9 – Perspective: No One Knows Exactly What Would Happen If Mosquitoes Were to Disappear – The Atlantic (free)

Related: Mosquitoes Genetically Modified To Crash Species That Spreads Malaria – NPR (free) AND Scientists use gene drive to eradicate lab mosquitoes for the first time – STAT (free) AND Malaria mosquitoes wiped out in lab trials of gene drive technique – Reuters (free)

 

10 – Ethanol lock is effective on reducing the incidence of tunneled catheter-related bloodstream infections in hemodialysis patients: a systematic review and meta-analysis – International Urology and Nephrology (link to abstract – $ for full-text)

Commentary: Ethanol locks in catheters for dialysis may prevent sepsis – NIHR Signal (free)

 


 

1 – Phase 2b Controlled Trial of M72/AS01E Vaccine to Prevent Tuberculosis – New England Journal of Medicine (free)

Editorial: New Promise for Vaccines against Tuberculosis (free)

Commentaries: New TB vaccine protects half of people with latent infection – NBC Health News (free) AND Experimental vaccine shows promise in preventing TB – MedicalXpress (free)

 

2 – Systematic review update of observational studies further supports aspirin role in cancer treatment: Time to share evidence and decision-making with patients? – PLOS One (free)

Commentaries: Aspirin could play key role in treating some cancers – UPI (free) AND Could aspirin play role in treatment of cancer? – Cardiff University (free)

 

3 – Two‐year results of the randomized clinical trial DILALA comparing laparoscopic lavage with resection as treatment for perforated diverticulitis – British Journal of Surgery (free)

Commentary: Comparing Laparoscopic Lavage vs Resection for Perforated Diverticulitis – Medscape (free registration required)

 

4 – Temporal trends in muscular fitness of English 10-year-olds 1998–2014: An allometric approach – Journal of Science and Medicine in Sport (link to abstract – $ for full-text)

Commentary: Fall in strength and fitness of 10-year-olds, study shows – BBC (free) AND Ten-Year-Olds Are Weaker Today Than They Were 16 Years Ago – HuffPost (free) AND British study reveals fall in muscle strength of 10-year-olds – The Guardian (free)

 

5 – STAT’s cheerleading coverage of prescription fish oil capsule lacks crucial context – Health News Review (free)

Original Commentary: Amarin fish oil capsule shows dramatic benefit for cardiovascular patients, potentially upending market – STAT (free)

 

6 – Conventional Autopsy versus Minimally Invasive Autopsy with Postmortem MRI, CT, and CT-guided Biopsy: Comparison of Diagnostic Performance – Radiology (free for a limited period) (via @EricTopol)

Commentary: Minimally invasive autopsy improves postmortem diagnoses – Radiology Society of North America (free)

Related Systematic Review: Non-invasive or minimally invasive autopsy compared to conventional autopsy of suspected natural deaths in adults  – European Radiology (free)

 

7 – Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial – JAMA Psychiatry (free for a limited period) (via @EricTopol)

Commentary: Insomnia symptoms, overall health improve with online insomnia program – Northwestern University (free)

 

8 – Association between physician US News & World Report medical school ranking and patient outcomes and costs of care: observational study – The BMJ (free)

“Overall, little or no relation was found between the USNWR ranking of the medical school from which a physician graduated and subsequent patient mortality or readmission rates.”

 

9 – Modifying the consistency of food and fluids for swallowing difficulties in dementia – Cochrane Library (free for a limited period)

Summary: Modifying the consistency of food and fluids for swallowing difficulties in dementia (free)

“We are uncertain about the immediate and long-term effects of modifying the consistency of fluid for swallowing difficulties in dementia”

 

10 – Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies – Molecular Psychiatry (link to abstract – $ for full-text)

Commentaries: Plant-rich diets may help prevent depression – new evidence – The Conversation (free) AND Eating a Mediterranean diet ‘may lower your risk of depression’ – NHS Choices (free) AND Expert reaction to observational studies on diet and depression – Science Media Centre (free) AND Mediterranean diet could prevent depression, new study finds – CNN (free)

“The current evidence is not sufficient to prove plant-rich diets can prevent depression as most of the evidence so far simply shows that those with poorer mental health eat worse, so it may be that those more prone to depression also choose less health” (from CNN)

 


 

1 – Five-Year Follow-up of Antibiotic Therapy for Uncomplicated Acute Appendicitis in the APPAC Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Podcast: Treating Appendicitis Without Surgery – 5-Year Follow-up from a Randomized Clinical Trial of Antibiotic Treatment (free)

Video Summary: Five-Year Follow-up of Patients Given Antibiotic Therapy for Uncomplicated Acute Appendicitis (free)

Commentaries: Pills for appendicitis? Surgery often not needed, study says – STAT (free) AND Antibiotics Alone Seem Reasonable for Uncomplicated Appendicitis in Adults – Physician’s First Watch (free) AND Appendicitis? Antibiotics May Be All You Need – The New York Times (10 articles per month are free)

Related: Randomized clinical trial of antibiotic therapy for uncomplicated appendicitis (link to abstract and commentaries) AND Antibiotics Versus Surgical Therapy for Uncomplicated Appendicitis (link to abstract and commentaries) AND Antibiotic Therapy versus Appendectomy for Acute Uncomplicated Appendicitis (free study and commentaries) AND New appendicitis guideline incorporates the possibility of non-operative treatment for uncomplicated disease (free guideline)

 

2 – Type 1 Diabetes in Children and Adolescents: A Position Statement by the American Diabetes Association – Diabetes Care (free)

 

3 – Recovery of Over-Ground Walking after Chronic Motor Complete Spinal Cord Injury – New England Journal of Medicine (free)

Commentaries: Technology and therapy help individuals with chronic spinal cord injuries take steps – University of Louisville (free) AND Epidural Stimulation Helps Patients Walk After Total Paralysis – MedPage Today (free registration required) AND Paralyzed Patients Able to Walk Following Epidural Stimulation, Intense Rehab – Physician’s First Watch (free)

 

4 – Prevalence of drug–herb and drug–supplement interactions in older adults: a cross-sectional survey – British Journal of General Practice (free)

Commentaries: New study finds concurrent use of prescription drugs and dietary supplements could pose health risks – University of Hertfordshire (free) AND Concerns raised about older adults mixing prescription drugs and herbal remedies – NHS Choices (free)

 

5 – Development and Validation of Deep Learning–based Automatic Detection Algorithm for Malignant Pulmonary Nodules on Chest Radiographs – Radiology (link to abstract – $ for full-text)

Commentary: Deep learning algorithm detects malignant pulmonary nodules better than radiologists – Radiology Business (free)

Related Studies: Deep Learning for the Diagnosis of Fibrotic Lung Disease (link to abstract and commentaries) AND Can Artificial Intelligence Reliably Report Chest X-Rays? (free study and commentaries) AND Artificial Intelligence Can Determine Lung Cancer Type (link to abstract and commentaries)

 

6 – Measuring human capital: a systematic analysis of 195 countries and territories, 1990–2016 – The Lancet (free)

Commentary: Unprecedented study finds nations failing to invest in education and health care at risk of slow economic growth – Institute for Health Metrics and Evaluation (free)

Infographic: What is human capital and why is it relevant? – Institute for Health Metrics and Evaluation (free)

The first-ever study ranking countries by human capital has been published in @TheLancet. This novel approach looks at nations’ investments in health and education and their relation to GDP growth” (via @IHME_UW see Tweet)

 

7 – Pharmacokinetics–pharmacodynamics issues relevant for the clinical use of beta-lactam antibiotics in critically ill patients – Critical Care (free)

Related: Extended Antibiotic Infusions Could Save Lives: Here’s How to Do It (free commentary) AND Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (link to abstract and free commentary)

 

8 – Ebola response faces ‘grave obstacles’ as count hits 150 – CIDRAP (free)

Related: WHO warns of ‘perfect storm’ for Ebola in eastern Congo – STAT (free) AND WHO extremely concerned about Ebola ‘perfect storm’ in Congo – Reuters (free)

 

9 – Adverse outcomes after arthroscopic partial meniscectomy: a study of 700 000 procedures in the national Hospital Episode Statistics database for England – The Lancet (free)

Invited Commentary: Potential harms of isolated arthroscopic partial meniscectomy (free)

Related: Needless procedures: knee arthroscopy is one of the most common but least effective surgeries – The Conversation (free) AND Arthroscopic surgery for degenerative knee arthritis and meniscal tears: a clinical practice guideline (free guideline and commentary)

 

10 – Effect of Algorithm-Based Therapy vs Usual Care on Clinical Success and Serious Adverse Events in Patients with Staphylococcal Bacteremia: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Treatment Algorithms for Staphylococcal Bacteremia: Improving Clinical Care and Enhancing Antimicrobial Stewardship (free for a limited period)

Commentary: Algorithm may reduce antibiotics for staph bloodstream infections – CIDRAP (free)

 


 

1 – Noncommunicable Diseases Country Profiles 2018 – World Health Organization (free PDF)

See also: NCDs profile by country (free)

 

2 – Transcatheter Mitral-Valve Repair in Patients with Heart Failure – New England Journal of Medicine (free)

Commentary: COAPT: MitraClip Reduces Repeat Hospitalizations, Mortality in Functional MR Patients With Severe HF – TCTMD (free)

Related MITRA-FR trial: Percutaneous Repair or Medical Treatment for Secondary Mitral Regurgitation – New England Journal of Medicine (free)

“Physicians responded with shock and excitement to findings, but struggled to reconcile the results with the MITRA-FR trial.” (from TCTMD)

 

3 – Effect of Variation in Published Stroke Rates on the Net Clinical Benefit of Anticoagulation for Atrial Fibrillation – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Benefit of anticoagulation for stroke prevention may vary in patients with afib, study finds – ACP Internist (free)

 

4 – Review: Streptococcal toxic shock syndrome in the intensive care unit – Annals of Intensive Care (free)

Source: Critical Care Reviews Newsletter

 

5 – Targeted temperature management in patients with intracerebral haemorrhage, subarachnoid haemorrhage, or acute ischaemic stroke: consensus recommendations – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter

 

6 – Podcast: #115 Geriatric Depression – The Curbsiders Internal Medicine Podcast (free)

Summary: #115 Geriatric Depression: Diagnosis, Antidepressants, and More (free)

 

7 – Ann Robinson’s research reviews, 24 September 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 

8 – Congratulations. Your Study Went Nowhere – The New York Times (10 articles per month are free) (via @kennylinafp)

“Researchers should embrace negative results instead of accentuating the positive, which is one of several biases that can lead to bad science.”

 

9 – Just Started! Free Online Course: Antibiotic Stewardship – Stanford University and Coursera (via @classcentral)

 

10 – Double check patients with ‘penicillin allergy’ to avoid increased MRSA risk – NICE News and Features (free)

Related Study: Risk of Meticillin Resistant Staphylococcus Aureus and Clostridium Difficile in Patients with a Documented Penicillin Allergy (free article and commentaries)

 


 

1 – Global status report on alcohol and health 2018 – World Health Organization (free PDF)

News Release: Harmful use of alcohol kills more than 3 million people each year, most of them men (free)

Commentaries: Alcohol abuse kills 3 million a year, most of them men: WHO – Reuters (free) AND 1 in 20 deaths globally is a result of alcohol use – CNN (free) AND Alcohol causes one in 20 deaths worldwide, says WHO – The Guardian (free)

 

2 – NCD Countdown 2030: worldwide trends in non-communicable disease mortality and progress towards Sustainable Development Goal target 3.4 – The Lancet (free registration required)

Commentaries: Most nations falling short of targets to cut early deaths from chronic disease – Imperial College London (free) AND New Data Suggest More Than Half of Countries Not on Track to Meet Global NCD Goals – American College of Cardiology (free) AND Globally, losing the fight against cancer and other chronic diseases – CNN (free)

 

3 – Residual vein occlusion in relation to immediate compression and postthrombotic syndrome in deep vein thrombosis – Blood (free PDF)

Commentary: Immediate compression could help prevent complications after deep-vein thrombosis – American Society of Hematology (free)

“Study supports use of this simple, low-cost intervention even for patients without symptoms” (from American Society of Hematology)

 

4 – Clinical Update: Management of Chronic Wounds—2018 – JAMA (free for a limited period)

 

5 – Diagnostic Test Interpretation: Diagnostic Testing for Elevated Cortisol in the Setting of an Adrenal Mass – JAMA (free for a limited period)

 

6 – ‘Latent’ Tuberculosis? It’s Not That Common, Experts Find – The New York Times (1o articles per month are free)

Related Analysis: Revisiting the timetable of tuberculosis – The BMJ (free analysis and commentary)

 

7 – The cost of persuasive design: digital media use and ADHD – The Mental Elf (free)

Original Study: Association of Digital Media Use with ADHD Among Adolescents (link to abstract and free commentaries)

 

8 – Amazing ways artificial intelligence is used in healthcare – World Economic Forum (free)

 

9 – Global epidemiology and outcomes of acute kidney injury – Nature Reviews Nephrology (free for a limited period) (via @Abraham_RMI)

 

10 – Racial and ethnic estimates of Alzheimer’s disease and related dementias in the United States (2015–2060) in adults aged ≥65 years – Alzheimer’s & Dementia (free for a limited period)

Commentaries: Alzheimer’s and dementia cases will double by 2060 -HealthExec (free) AND Alzheimer’s Burden Projected to Double by 2060 – Physician’s First Watch (free) AND Alzheimer’s Disease Burden to Double by 2060 – MedPage Today (free registration required)

 


 

1 – Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Infectious Diseases (free)

Invited Commentary: The global burden of lower respiratory infections: making progress, but we need to do better (free)

 

2 – Estimates of the global, regional, and national morbidity, mortality, and aetiologies of diarrhoea in 195 countries: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Infectious Diseases (free)

Invited Commentary: Old and new challenges related to global burden of diarrhea (free)

Related Report: Variation in Childhood Diarrheal Morbidity and Mortality in Africa (free article and commentaries)

 

3 – Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits – Nature Genetics (link to abstract – $ for full-text)

Commentaries: World’s biggest study of blood pressure genetics – Queen Mary University of London (free) AND Researchers find 535 new gene regions that influence blood pressure – UPI (free) AND High blood pressure breakthrough: Over 500 genes uncovered – Medical News Today (free)

 

4 – Modeling NAFLD disease burden in China, France, Germany, Italy, Japan, Spain, United Kingdom, and United States for the period 2016–2030 – Journal of Hepatology (free)

Editorial: Predicting the future burden of NAFLD and NASH (free)

 

5 – Incidence of cardiovascular disease up to 13 year after cancer diagnosis: A matched cohort study among 32 757 cancer survivors – Cancer Medicine (free)

 

6 – The preventable proportion of healthcare-associated infections 2005–2016: Systematic review and meta-analysis – Infection Control & Hospital Epidemiology (link to abstract – $ for full-text)

Commentary: Even the best healthcare facilities can do more to prevent infections – Society for Healthcare Epidemiology of America (free)

“Multifaceted tactics for infection control reduce healthcare-associated infections 35-55 percent”

 

7 – Analysis: Diagnostic expansion in clinical trials: myocardial infarction, stroke, cancer recurrence, and metastases may not be the hard endpoints you thought they were – The BMJ (free)

 

8 – Perspective: The Case For Expensive Antibiotics – Wired (a few articles per month are free) (via @CarlosdelRio7)

 

9 – Opinion: Everything You Know About Obesity Is Wrong – HuffPost (free) (via @cardiobrief)

“For decades, the medical community has ignored mountains of evidence to wage a cruel and futile war on fat people, poisoning public perception and ruining millions of lives.”

 

10 – Association between maternal gluten intake and type 1 diabetes in offspring: national prospective cohort study in Denmark – The BMJ (free)

Editorial: Dietary gluten and type 1 diabetes (free for a limited period)

Commentaries: Expert reaction to research on high gluten intake during pregnancy and type 1 diabetes in children – Science Media Centre (free) AND Higher Gluten Intake in Pregnancy Tied to Increased Diabetes Risk in Offspring – Physician’s First Watch (free) AND High gluten intake during pregnancy associated with diabetes – OnMedica (free)

“As such these results, whilst well executed and very interesting, would need to be confirmed within independent similarly sized or bigger studies as stated by the authors themselves.” (from Science Media Centre)

 


 

1 – Variation in Childhood Diarrheal Morbidity and Mortality in Africa, 2000–2015 – New England Journal of Medicine (free)

News Release: Discomfort or death? New study maps hot spots of child mortality from diarrhea across Africa – Institute for Health Metrics and Evaluation (free)

Quick Take Video Summary: Variation in Childhood Diarrheal Morbidity and Mortality in Africa (free)

 

2 – Refractory septic shock: our pragmatic approach – Critical Care (free)

 

3 – Intensification of older adults’ outpatient blood pressure treatment at hospital discharge: national retrospective cohort study – The BMJ (free)

Commentaries: Study: Hospitals may overprescribe blood pressure meds – UPI (free) AND Veterans overtreated for blood pressure on leaving hospital – MedicalXpress (free) AND Antihypertensive treatment intensified at discharge regardless of outpatient blood pressure history – ACP Hospitalist (free)

 

4 – Meta-analyses were supposed to end scientific debates. Often, they only cause more controversy – Science (free) (via @Onisillos)

 

5 – Oral Fluoroquinolone and the Risk of Aortic Dissection – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: The Fluoroquinolone/Aortic Dissection Association – Emergency Medicine Literature of Note (free)

Related observational studies with similar conclusions: Fluoroquinolone use and risk of aortic aneurysm and dissection (free articles)

 

6 – Deep learning for classifying fibrotic lung disease on high-resolution computed tomography: a case-cohort study – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Related Audio: Deep learning and fibrotic lung disease (free)

Commentary: Machine Tops Humans in Fibrotic Lung Disease Classification – Medical Health News (free)

 

7 – Neoadjuvant Chemoradiotherapy Followed by Surgery Versus Surgery Alone for Locally Advanced Squamous Cell Carcinoma of the Esophagus (NEOCRTEC5010): A Phase III Multicenter, Randomized, Open-Label Clinical Trial – Journal of Clinical Oncology (free)

Commentary: Neoadjuvant Chemoradiotherapy in Locally Advanced Esophageal Cancer – The ASCO Post (free)

Source: EvidenceAlerts

 

8 – Are noise and air pollution related to the incidence of dementia? A cohort study in London, England – BMJ Open (free)

Commentaries: Air pollution linked to dementia risk – NHS Choices (free) AND Expert reaction to air pollution and risk of dementia – Science Media Centre (free) AND Air pollution may be linked to heightened dementia risk – OnMedica (free) AND Is air pollution tied to higher dementia risk? – CNN (free)

 

9 – Nutritional quality of food as represented by the FSAm-NPS nutrient profiling system underlying the Nutri-Score label and cancer risk in Europe: Results from the EPIC prospective cohort study – PLOS Medicine (free)

Commentaries: Expert reaction to study looking at nutritional quality of food and risk of cancer – Science Media Centre (free) AND Foods with low nutritional quality tied to higher cancer risk – Medical News Today (free)

 

10 – Association of Medical Scribes in Primary Care With Physician Workflow and Patient Experience – JAMA Internal Medicine (free for a limited period)

Commentaries: Use of Medical Scribes to Reduce Documentation Burden: Are They Where We Need to Go With Clinical Documentation? – JAMA Internal Medicine (free for a limited period) AND Scribes improve physician workflow, patient interaction – MedicalXpress (free) AND Scribes ease physician administrative burden and boost patient experience, JAMA study says – Healthcare Finance (free)

 


 

1 – Global Tuberculosis Report 2018 – World Health Organization (free PDF)

Commentaries: UN tuberculosis summit ‘historic opportunity’ to put response ‘back on track’: new WHO report – UN News (free) AND WHO TB Report Sets Stage for Historic U.N.TB Meeting – American Thoracic Society (free) AND WHO report warns efforts to end TB are falling short – CIDRAP (free)

 

2 – Positive Pressure Ventilation in the Cardiac Intensive Care Unit – Journal of the American College of Cardiology (free for a limited period) (via @Abraham_RMI)

 

3 – Can Artificial Intelligence Reliably Report Chest X-Rays?: Radiologist Validation of an Algorithm trained on 1.2 Million X-Rays – Cornell University Library (free PDF)

News Release: Qure.ai’s qXR Algorithm can ID Abnormal Chest X-rays With Unprecedented Accuracy (free)

Commentary: AI algorithm IDs abnormal chest x-rays with 90% accuracy – Health Imaging (free) AND AI startup trains algorithm with 1.2M chest x-rays, confirms its accuracy – Radiology Business (free)

 

4 – Classification and mutation prediction from non–small cell lung cancer histopathology images using deep learning – Nature Medicine (link to abstract – $ for full-text)

Commentaries: Artificial intelligence can determine lung cancer type – eCancer News (free) AND Google AI Tool Identifies a Tumor’s Mutations From An Image – WIRED (free)

 

5 – Behavioral Weight Loss Interventions to Prevent Obesity-Related Morbidity and Mortality in Adults: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Author Interview: USPSTF Recommendation: Behavioral Interventions to Prevent Adult Obesity-Related Outcomes (free)

Editorials: Weight Management in Adults With Obesity: What Is a Primary Care Clinician to Do? (free for a limited period) AND Treating Obesity—Moving From Recommendation to Implementation (free for a limited period)

Commentaries: Intensive lifestyle changes best for people with BMI above 30, task force says – UPI (free) AND Doctors Should Send Obese Patients To Diet Counseling, Panel Says. But Many Don’t – NPR (free)

 

6 – Efficacy and Safety of Short‐term Dual Antiplatelet Therapy (≤ 6 Months) after Percutaneous Coronary Intervention for Acute Coronary Syndrome; A Systematic Review and Meta‐analysis of Randomized Controlled Trials – Clinical Cardiology (free PDF)

 

7 – Daily Fasting Improves Health and Survival in Male Mice Independent of Diet Composition and Calories – Cell Metabolism (link to abstract and infographic – $ for full-text)

Commentaries: Fasting increases health and lifespan in male mice – NIH Research Matters (free) AND Study: Mice healthier, live longer with increased daily fasting times – UPI (free) AND Study: Daily Fasting Improves Health and Longevity in Male Mice – Sci News (free)

 

8 – Higher Whole-Grain Intake Is Associated with Lower Risk of Type 2 Diabetes among Middle-Aged Men and Women: The Danish Diet, Cancer, and Health Cohort – The Journal of Nutrition (link to abstract – $ for full-text)

Commentary: What you need to know about claims that whole grains can prevent diabetes – Health News Review (free)

 

9 – Association of Hospital Participation in a Medicare Bundled Payment Program With Volume and Case Mix of Lower Extremity Joint Replacement Episodes – JAMA (link to abstract – $ for full-text)

Commentaries: Can Paying for a Health Problem as a Whole, Not Piece by Piece, Save Medicare Money? – The New York Times (10 articles per month are free) AND Medicare’s Bundled Payment Program–Does it Change Hospital Volume or Case Mix? – MedicalResearch.com (free) AND One of Obamacare’s big experiments to lower costs is working surprisingly well – VOX (free)

 

10 – Prevalence of Burnout Among Physicians: A Systematic Review – JAMA (link to abstract – $ for full-text)

Commentaries: Doctors Today May Be Miserable, But Are They ‘Burnt Out’? – NPR (free) AND Physician burnout taking center stage – Reuters (free) AND Burnout Found to Be Common Among U.S. Resident Physicians – Psychiatric News Alert (free)

Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians (free) AND The Burnout Crisis in American Medicine – The Atlantic (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record (free commentaries)

 


 

1 – Implementing Optimal Team-Based Care to Reduce Clinician Burnout – National Academy of Medicine (free)

Commentaries: Optimal team-based health care is associated with improved patient outcomes and physician well-being – ACP Newsroom (free) AND New Review Shows Team-Based Care May Reduce Physician Burnout – Medscape (free registration required)

 

2 – Diagnosis and management of Aspergillus diseases: executive summary of the 2017 ESCMID-ECMM-ERS guideline – Clinical Microbiology and Infection (free)

Related: Practice Guidelines for the Diagnosis and Management of Aspergillosis: 2016 Update by the Infectious Diseases Society of America (free)

Source: Critical Care Reviews Newsletter

 

3 – Viewpoint: Probiotic Safety—No Guarantees – JAMA Internal Medicine (free for a limited period)

Related: Probiotics: Does the Evidence Match the Hype? (free articles and commentaries) AND Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries)

 

4 – Zackary Berger’s journal reviews, 17 September 2018 – The BMJ Opinion (free)

Zackary Berger reviews the latest research from the top medical journals.

 

5 – Opinion: Medicine’s Financial Contamination – The New York Times (10 articles per month are free)

 

6 – Infant Walker–Related Injuries in the United States – Pediatrics (free)

News Release: Study: Infant walker injuries support AAP’s call for a ban (free)

Commentaries: As Injuries Continue, Doctors Renew Call For Ban On Infant Walkers – NPR (free) AND Injuries associated with infant walkers still sending children to the emergency department – Nationwide Children’s Hospital (free)

 

7 – Ensuring Comprehensive Care and Support for Transgender and Gender-Diverse Children and Adolescents – Pediatrics (free)

News release: AAP Policy Statement Urges Support and Care of Transgender and Gender-Diverse Children and Adolescents (free) AND New Guidance for Care of Transgender Children, Teenagers – Medscape (free registration required)

 

8 – Let’s stop the burning and the bleeding at Cochrane—there’s too much at stake – The BMJ Opinion (free)

Related: Evidence-based medicine group in turmoil after expulsion of co-founder – Science (free) AND Trish Greenhalgh: The Cochrane Collaboration—what crisis? – The BMJ Opinion (free) AND Cochrane – A sinking ship? – BMJ EBM Spotlight (free) AND Turmoil erupts over expulsion of member from leading evidence-based medicine group – STAT (free)

See also: Statement from Cochrane’s Governing Board (free)

 

9 – Treatments of Primary Basal Cell Carcinoma of the Skin: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (free)

 

10 – Development of a New Classification System for Idiopathic Inflammatory Myopathies Based on Clinical Manifestations and Myositis-Specific Autoantibodies – JAMA Neurology (link to abstract – $ for full-text)

Commentary: New Classification of Idiopathic Inflammatory Myopathies – RheumNow (free)

 


 

1 – Effect of Aspirin on All-Cause Mortality in the Healthy Elderly – New England Journal of Medicine (free) (via @EricTopol)

Related Studies: Effect of Aspirin on Cardiovascular Events and Bleeding in the Healthy Elderly – New England Journal of Medicine (free) AND Effect of Aspirin on Disability-free Survival in the Healthy Elderly – New England Journal of Medicine (free)

Commentaries: Daily low-dose aspirin found to have no effect on healthy life span in older people- NIH News Releases (free) AND Low-Dose Aspirin Late in Life? Healthy People May Not Need It – The New York Times (10 articles per month are free)

 

2 – WHO water, sanitation and hygiene strategy 2018-2025 – World Health Organization (free PDF)

 

3 – Optimizing medications in older adults with cognitive impairment: Considerations for primary care clinicians – Canadian Family Physicians (free)

 

4 – Viewpoint: Antibiotics for Sepsis—Finding the Equilibrium – JAMA (free for a limited period)

 

5 – Shared Decision-Making: Staying Focused on the Ultimate Goal – NEJM Catalyst (free)

 

6 – Ig Nobel win for kidney stone removing roller-coaster – BBC (free)

Related: Ig Nobel prizes honor do-it-yourself colonoscopies, a curious use for postage stamps, and other peculiar research – Science (free)

 

7 – Can health services handle the Apple Watch? – BBC (free)

Related: The New Apple Watch 4: Cardiac Accuracy Unknown, “Game-Changing” Benefits Overblown – The Skeptical Cardiologist (free) AND The New ECG Apple Watch Could do More Harm Than Good – Wired (a few articles per month are free)

See also: New Watch can Help Doctors Monitor your Heart in Real Time (free commentaries)

 

8 – Patients vs. paywalls: Is the U.S. ready for open-access publishing? – STAT (free)

Related: Scientific publishing is a rip-off. We fund the research – it should be free – The Guardian (free) AND cOAlition S: Making Open Access a Reality by 2020 (free Statement and commentaries)

 

9 – Prevalence of Chronic Pain and High-Impact Chronic Pain Among Adults — United States, 2016 – Centers for Disease Control and Prevention (free)

Commentaries: Chronic Pain Affects 20% of Americans, CDC Reports – MedPage Today (free registration required) AND CDC: About 1 in 5 US Adults Have Chronic Pain – MPR (free) AND One-fifth of American adults experience chronic pain, CDC estimates – CNBC (free)

 

10 – Total Medicare Costs Associated With Diagnosis and Treatment of Prostate Cancer in Elderly Men – JAMA Oncology (link to abstract – $ for full-text)

Commentaries: Are Older Prostate Cancer Patients Overtreated? – MedPage Today (free registration required)

 


 

1 – Resistant Hypertension: Detection, Evaluation, and Management: A Scientific Statement From the American Heart Association – Hypertension (free PDF)

News Release: Diagnosing and treating resistant hypertension (free)

Commentaries: Tackling Resistant Hypertension – Opportunities and Challenges (free) AND Heart Group Updates Guidelines on Resistant Hypertension – Physician’s First Watch (free)

Top Ten Things to Know: Resistant Hypertension: Detection, Evaluation, and Management (free PDF)

 

2 – Elevated blood pressure and risk of aortic valve disease: a cohort analysis of 5.4 million UK adults – European Heart Journal (free)

Commentary: Elevated blood pressure is linked to increased risk of aortic valve disease – European Society of Cardiology (free)

 

3 – Global Cancer Statistics 2018: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries – CA: A Cancer Journal for Clinicians (free)

See also: Latest global cancer data: Cancer burden rises to 18.1 million new cases and 9.6 million cancer deaths in 2018 – International Agency for Research on Cancer (free PDF)

Infographic: Global Cancer Data 2018 (free)

Commentaries: WHO: 9.6 million cancer deaths, 18 million new cases this year – UPI (free) AND Cancer will kill nearly 10 million people this year, report estimates – CNN (free) AND Cancer deaths rise to 9.6 million as populations grow and age – Reuters (free)

 

4 – Are Invasive Procedures Effective for Chronic Pain? A Systematic Review – Pain Medicine (free)

Commentaries: New study questions effectiveness of invasive procedures for chronic pain – The Reis Group (free) AND Invasive Procedures For Chronic Pain Have Not Been Proven to Work – MedicalResearch.com (free)

Related: Needless procedures: knee arthroscopy is one of the most common but least effective surgeries – The Conversation (free)

 

5 – What 21st Century Health Care Should Learn from 20th Century Business – NEJM Catalyst (free)

 

6 – The New ECG Apple Watch Could do More Harm Than Good – Wired (a few articles per month are free) (via @EricTopol)

See also: New Watch can Help Doctors Monitor your Heart in Real Time (free commentaries)

 

7 – Opinion: Scientific publishing is a rip-off. We fund the research – it should be free – The Guardian (free)

Related: cOAlition S: Making Open Access a Reality by 2020 (free Statement and commentaries)

 

8 – Thousands of scientists publish a paper every five days – Nature (free)

Related: Some scientists publish more than 70 papers a year. Here’s how—and why—they do it – Science (free)

 

9 – Effect of organised mammography screening on breast cancer mortality: A population‐based cohort study in Norway – International Journal of Cancer (free)

Commentaries: Breast cancer screening does not reduce mortality – eCancer News (free) AND Danish study attributes improved treatment, not screening, to decline in breast cancer deaths – Health Imaging (free)

 

10 – Fatal Toxic Effects Associated With Immune Checkpoint Inhibitors: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)

Commentaries: Study Discerns Rare Risks of Fatal Side Effects From Cancer Immunotherapy – AJMC (free) AND Fatal Toxicities Rare With Checkpoint Inhibitors – MedicalResearch.com (free)

Related Guidelines: Management of Immune-Related Adverse Events in Patients Treated With Immune Checkpoint Inhibitor Therapy: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Managing toxicities associated with immune checkpoint inhibitors: consensus recommendations from the Society for Immunotherapy of Cancer (SITC) Toxicity Management Working Group (free)

Related Review: New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free)

 


 

1 – Guideline: Chronic heart failure in adults: diagnosis and management – National Institute for Health and Care Excellence (free)

 

2 – European Union Standards for Tuberculosis Care – European Centre for Disease Prevention and Control (free PDF in several languages) (via @ECDC_TB and @Onisillos)

 

3 – Review: Arterial Hypertension: Diagnosis and treatment – Deutsches Ärzteblatt international (free)

 

4 – USPSTF Draft Recommendation Statement: Ocular Prophylaxis for Gonococcal Ophthalmia Neonatorum (free)

Commentaries: USPSTF Again Recommends Ointment to Prevent Gonococcal Eye Infection in Newborns – Physician’s First Watch (free) AND USPSTF Reaffirms Ocular Prophylaxis for All Newborns – MedPage Today (free)

 

5 – New watch can help doctors monitor your heart in real time – American Heart Association News (free)

See also: The new Apple Watch, with FDA’s blessing, comes with an EKG app – STAT (free)

Related: USPSTF Statement: Screening with Resting or Exercise Electrocardiography (ECG) Not Recommended (free Guideline and commentaries) AND Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? (free commentaries) AND Get Ready For A Tsunami Of ECGs (free commentaries)

 

6 – Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician (free) (via @cantaskforce)

Related: Overdiagnosis across medical disciplines: a scoping review – The BMJ Open (free) AND Too much medical care: bad for you, bad for health care systems – STAT News (free) AND Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine (free) AND Position Paper on Overdiagnosis and Action to be Taken – Wonca (free PDF)

 

7 – FDA News Release: FDA takes new steps to address epidemic of youth e-cigarette use, including a historic action against more than 1,300 retailers and 5 major manufacturers for their roles perpetuating youth access (free)

Commentaries: FDA: we might have to ban some e-cigarettes to stop teens from vaping – VOX (free) AND FDA Intensifies Crackdown On E-Cigarette Sales To Teenagers – NPR (free)

“The agency is eyeing a crackdown on flavored e-cigs in the face of an “epidemic” of teen use.” (from VOX)

 

8 – Restrictive compared with liberal red cell transfusion strategies in cardiac surgery: a meta-analysis – European Heart Journal (free)

Related study: Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery (link to abstract)

 

9 – Report: Egg freezing in fertility treatment Trends and figures: 2010-2016 – Human Fertilisation and Embryology Authority (HFEA) (free PDF)

Press release: Age is the key factor for egg freezing success says new HFEA report, as overall treatment numbers remain low (free)

Commentaries: Expert reaction to HFEA report on trends in egg freezing – Science Media Centre (free) AND Freeze eggs before 35 for a better chance of IVF success, says report – The Guardian (free)

 

10 – Factors Associated With Long-term Benzodiazepine Use Among Older Adults – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: 1 in 4 Older Adults Prescribed a Benzodiazepine Goes on to Risky Long-Term Use, Study Finds – Michigan Medicine, via NewsWise (free) AND Long-Term Benzodiazepine Use Common Among Older Adults – Physician’s First Watch (free) AND Factors Predicting Long-term Benzodiazepine Use Identified – Medscape (free registration required) AND Larger Number of Benzodiazepine Pills in Initial Prescription Associated With Long Term Use – MedicalResearch.com (free)

Related: A Quiet Drug Problem Among the Elderly – The New York Times (free) AND Our Other Prescription Drug Problem – New England Journal of Medicine (free) AND Benzodiazepines: our other prescription drug epidemic – STAT (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)

 


 

1 – Effect of Piperacillin-Tazobactam vs Meropenem on 30-Day Mortality for Patients With E coli or Klebsiella pneumoniae Bloodstream Infection and Ceftriaxone Resistance: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Effect of Piperacillin-Tazobactam vs Meropenem on Mortality in Gram-Negative Bloodstream Infection – JAMA (free)

Commentaries: Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free) AND Drug Combo No Better for Hard-to-Treat Bloodstream Infections – Medscape (free registration required)

“The results do not support the use of Pip/Tazo as 30 d mortality was 12.3% in Pip/Tazo vs 3.7% in Mero arms” (via @CarlosdelRio7 see Tweet)

 

2 – Antibiotics for acute rhinosinusitis in adults – Cochrane Library (free for a limited period)

Summary: Antibiotics for sinus infection of short duration in adults – Cochrane Library (free)

“Considering antibiotic resistance, and the very low incidence of serious complications, we conclude there is no place for antibiotics for people with uncomplicated acute rhinosinusitis.”

 

3 – Opinion: Are We Being Misled About Precision Medicine? – The New York Times (10 articles per month are free)

“Doctors and hospitals love to talk about the cancer patients they’ve saved, and reporters love to write about them. But deaths still vastly outnumber the rare successes.”

 

4 – Comparisons of Guidelines and Recommendations on Managing Antineutrophil Cytoplasmic Antibody–Associated Vasculitis – Kidney International Reports (free)

 

5 – Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free)

“All screening programs do harm, some do good as well.”

 

6 – Last Month in Oncology with Dr. Bishal Gyawali: August 2018 – eCancer News (free)

 

7 – Alex Nowbar’s research reviews, 10 September 2018 – The BMJ (free)

 

8 – How well do you know your anticholinergic (antimuscarinic) drugs? – Therapeutics Initiative (free)

 

9 – Long-term Outcomes of the Effects of Home Blood Pressure Telemonitoring and Pharmacist Management on Blood Pressure Among Adults With Uncontrolled Hypertension: Follow-up of a Cluster Randomized Clinical Trial – JAMA Network Open (free)

Commentary: Pharmacist-Led BP Telemonitoring Intervention Works Up to 1 Year After Program Stops – TCTMD (free)

 

10 – Association of dairy intake with cardiovascular disease and mortality in 21 countries from five continents (PURE): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: The Lancet: Dairy consumption linked to lower rates of cardiovascular disease and mortality – EurekAlert (free) AND Dairy food in moderation ‘may protect the heart’ – The Guardian (free) AND Is Whole-Fat Dairy Good for the Heart? – New York Times (free)

Related: Meta-Analysis: Cheese consumption and risk of cardiovascular disease (link to abstract and commentaries) AND Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality (free study and commentaries)

“It is not the ultimate seal of approval for recommending whole-fat dairy over its low-fat or skimmed counterparts. Readers should be cautious, and treat this study only as yet another piece of the evidence (albeit a large one) in the literature.”

 


 

World #SuicidePrevention Day Highlights (10 September 2018)

 

1 – Preventing suicide A community engagement toolkit – World Health Organization (free PDF)

Fact Sheet: Suicide – World Health Organization (free)

 

2 – Guideline: Preventing suicide in community and custodial settings – National Institute for Health and Care Excellence (free)

 

3 – Chronic Pain Among Suicide Decedents, 2003 to 2014: Findings From the National Violent Death Reporting System – Annals of Internal Medicine (free)

Editorial: Pain, Opioids, and Suicide Mortality in the United States (free)

Commentaries: Chronic pain may contribute to suicide, study warns – Reuters (free) AND Chronic Pain Tied to Increased Suicide Risk – NEJM Physician’s First Watch (free) AND Increasing rates of chronic pain found among those who die by suicide – ACP Internist (free)

 

4 – It’s Hard for Doctors to Unlearn Things. That’s Costly for All of Us – The New York Times (10 articles per month are free) (via @CaulfieldTim)

 

5 – State of The Art Review: Perioperative lung protective ventilation – The BMJ (free for a limited period)

 

6 – Podcast: #113 Gout: Uric acid targets, urate lowering therapy, and random questions from social media – The Curbsiders Internal Medicine Podcast (free)

 

7 – Lifestyle changes reduce the need for blood pressure medications – American Heart Association Meeting Report (free)

Commentary: Lifestyle Interventions Cut Need for Antihypertensives Within Months – NEJM Physician’s First Watch (free)

 

8 – Pharmacist services for non‐hospitalised patients – Cochrane Library (free)

Summary: Can services delivered by pharmacists improve patient health? – Cochrane Library (free)

Commentaries: Pharmacists play vital role in improving patient health shows biggest review of evidence to date – University of Bath (free) AND Community pharmacy can significantly improve care in long-term conditions, large-scale analysis finds – The Pharmaceutical Journal (free)

 

9 – Effectiveness of a Therapeutic Tai Ji QuanIntervention vs a Multimodal Exercise Intervention to Prevent Falls Among Older Adults at High Risk of Falling: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Commentaries: Tai Chi May Work Best to Prevent Falls in Old Age – WebMD (free) AND Tai Ji Quan Can Reduce Falls in Elderly – MedicalResearch.com (free)

 

10 – Preventing Cognitive Decline in Black Individuals With Mild Cognitive Impairment: A Randomized Clinical Trial – JAMA Neurology (free for a limited period)

Commentary: Study provides evidence to prevent memory decline in older blacks with mild cognitive impairment – News Medical (free) AND Novel Intervention Markedly Slows Cognitive Decline in MCI – Medscape (free registration required)

 


 

1 – 2018 European Thyroid Association Guideline for the Management of Graves’ Hyperthyroidism – European Thyroid Journal (free) (via @CristobMorales and @Abraham_RMI)

 

2 – Consensus Recommendations for RBC Transfusion Practice in Critically Ill Children From the Pediatric Critical Care Transfusion and Anemia Expertise Initiative – Pediatric Critical Care Medicine (free)

 

3 – Viewpoint: Aligning Patient and Physician Incentives – JAMA (free for a limited period)

 

4 – Top Cancer Researcher Fails to Disclose Corporate Financial Ties in Major Research Journals – ProPublica (free)

 

5 – Financial Conflicts of Interest Among Oncologist Authors of Reports of Clinical Drug Trials – JAMA Oncology (link to abstract – $ for full-text)

Commentaries: Financial disclosure lacking in publication of clinical trials – eCancer News (free) AND Oncologist-Authors Often Do Not Fully Disclose Financial Relationships with Pharmaceutical Companies – MedicalResearch.com (free) AND One-third of oncologist authors fail to disclosure industry payments – Healio News (free registration required)

 

6 – Palliative care in intensive care units: why, where, what, who, when, how – BMC Anesthesiology (free)

 

7 – Idiopathic Pulmonary Fibrosis (IPF): An Overview – Journal of Clinical Medicine (free)

 

8 – Perspective: The Moral Dilemma of Learning Medicine from the Poor – The Doctors Weight In (free) (via @kennylinafp)

I learned good skills because I was allowed to practice on people who had no other option.”

 

9 – Peer reviewers unmasked: largest global survey reveals trends – Nature News (free)

Original Report: 2018 Global State of Peer Review (free)

 

10 – Variability in Ejection Fraction Measured By Echocardiography, Gated Single-Photon Emission Computed Tomography, and Cardiac Magnetic Resonance in Patients With Coronary Artery Disease and Left Ventricular Dysfunction – JAMA Network Open (free) (via @LuisCLCorreia)

“There is substantial variability in LVEF assessment between modalities, which should be considered in trial design and clinical management.”

 


 

1 – Guideline: Pancreatitis – National Institute for Health and Care Excellence (free)

 

2 – Clinically Localized Prostate Cancer: ASCO Clinical Practice Guideline Endorsement of an American Urological Association/American Society for Radiation Oncology/Society of Urologic Oncology Guideline – Journal of Clinical Oncology (free)

 

3 – Statins for primary prevention of cardiovascular events and mortality in old and very old adults with and without type 2 diabetes: retrospective cohort study – The BMJ (free)

Editorial: Primary prevention with statins for older adults (free)

Commentaries: Expert reaction to study on use of statins in older people – Science Media Centre (free) AND Widespread use of statins in healthy older people to prevent heart disease not recommended in new study – BMJ, via ScienceDaily (free)

New research does not support widespread use of statins in healthy older people to prevent heart disease and stroke. Results found that any protective effect was limited to those with type 2 diabetes aged between 75 and 84” (via @bmj_latest see Tweet)

 

4 – Commission: High-quality health systems in the Sustainable Development Goals era: time for a revolution – The Lancet Global Health (free articles)

Related Article: Mortality due to low-quality health systems in the universal health coverage era: a systematic analysis of amenable deaths in 137 countries – The Lancet (free)

Editorial: Putting quality and people at the centre of health systems – The Lancet (free)

Commentaries: Political and technical barriers to improving quality of health care – The Lancet (free) AND What Kills 5 Million People A Year? It’s Not Just Disease – NPR (free)

Related Report: Crossing the Global Quality Chasm: Improving Health Care Worldwide (free report and commentaries)

 

5 – The 2018 Surviving Sepsis Campaign’s Treatment Bundle: When Guidelines Outpace the Evidence Supporting Their Use – Annals of Emergency Medicine (free) (via @EMNerd)

Related Opinions: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free) AND The Surviving Sepsis Campaign: A Rush to Judgment – NEJM Journal Watch (free)

Original Guideline: The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)

 

6 – Tuberculosis: the curable disease on the rise, and how to tackle it – The Guardian (free)

 

7 – The treatment of anal fistula: second ACPGBI Position Statement – 2018 – Colorectal Disease (free)

 

8 – Guidelines for the Evaluation and Treatment of Perimenopausal Depression: Summary and Recommendations – Journal of Women’s Health (free)

Commentaries: First-Ever Guidelines for Detecting, Treating Perimenopausal Depression – University of Illinois at Chicago, via NewsWise (free) AND Guidelines for Managing Perimenopausal Depression Now Available – MPR (free)

 

9 – A pilot study using telehealth to implement antimicrobial stewardship at two rural Veterans Affairs medical centers – Infection Control & Hospital Epidemiology (free)

News Release: Telehealth Proves Valuable for Promoting Safe Antibiotic Prescribing Practices in Remote Healthcare Settings – Society for Healthcare Epidemiology of America (free)

Commentary: VA pilot study finds telehealth could aid stewardship – CIDRAP (free)

 

10 – Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features – Cell (free)

Related Article: Post-Antibiotic Gut Mucosal Microbiome Reconstitution Is Impaired by Probiotics and Improved by Autologous FMT – Cell (free)

Commentaries: Probiotics: Does the evidence match the hype? – Medical News Today (free) AND Probiotics labelled ‘quite useless’ – BBC (free)

 


 

1 – Ten Commandments of the 2018 ESC/ESH HTN Guidelines on Hypertension in Adults – European Heart Journal (free) (via @gonzaeperez)

 

2 – Rapid Recommendations: Prostate cancer screening with prostate-specific antigen (PSA) test: a clinical practice guideline – The BMJ (free)

Related guidelines: American Cancer Society Guideline for the Early Detection of Prostate Cancer (free) AND PSA-Based Prostate Cancer Screening in Men Aged 55-69 – American Academy of Family Physicians (free) AND USPSTF Recommendation Statement: Screening for Prostate Cancer (free guideline, editorial and commentaries)

 

3 – Antimicrobial Prophylaxis for Adult Patients With Cancer-Related Immunosuppression: ASCO and IDSA Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

See also: Guideline Update Summary (free)

 

4 – Baloxavir Marboxil for Uncomplicated Influenza in Adults and Adolescents – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Baloxavir for Uncomplicated Influenza (free)

Commentary: New single-dose antiviral cuts flu symptoms, viral loads – CIDRAP (free)

 

5 – Perspective: “Precision” Public Health — Between Novelty and Hype – New England Journal of Medicine (free)

 

6 – Guidance: Writing Outpatient Clinic Letters to Patients – Academy of Medical Royal Colleges (free PDF)

Commentaries: Doctors told to ditch Latin and use ‘plain English’ – BBC News (free) AND New drive to encourage doctors to write to patients in plain English – The Guardian (free) AND Rx for British Doctors: Use Plain English Instead of Latin – The New York Times (free)

“Guidance suggests specialists should avoid Latin terms, acronyms and convoluted language” (from The Guardian)

 

7 – Subsegmental pulmonary embolism: anticoagulation or observation? – PulmCCM (free)

 

8 – Policy Statement: Recommendations for Prevention and Control of Influenza in Children, 2018–2019 – American Academy of Pediatrics (free)

News Release: AAP Issues Flu Vaccine Recommendations for 2018-2019 (free)

 

9 – Diclofenac use and cardiovascular risks: series of nationwide cohort studies – The BMJ (free)

Commentary: Diclofenac Again Tied to Major Cardiovascular Events – NEJM Physician’s First Watch (free) AND ‘A major safety concern’: World’s most common NSAID doubles CVD risk – Cardiovascular Business (free)

 

10 – Machine learning models in electronic health records can outperform conventional survival models for predicting patient mortality in coronary artery disease – PLOS One (free)

Commentaries: AI beats doctors at predicting heart disease deaths – The Francis Crick Institute, via ScienceDaily (free) AND Novel AI algorithm beats cardiologists’ models in predicting heart disease mortality – Cardiovascular Business (free)

 


 

1 – cOAlition S: Making Open Access a Reality by 2020 – Science Europe (free)

See also: 10 principles of Plan S (free PDF) AND Press Release (free PDF)

Commentaries: Radical open-access plan could spell end to journal subscriptions – Nature News (free) AND ‘Plan S’ and ‘cOAlition S’ – Accelerating the transition to full and immediate Open Access to scientific publications – European Commission (free) AND Science without publication paywalls: cOAlition S for the realisation of full and immediate Open Access – PLOS Biology (free)

“…free access to all scientific publications from publicly funded research is a moral right of citizens.” (from European Comission)

 

2 – Centers for Disease Control and Prevention Guideline on the Diagnosis and Management of Mild Traumatic Brain Injury Among Children – JAMA Pediatrics (free)

Commentaries: CDC releases updated guideline on diagnosis and management of pediatric mTBI – Kennedy Krieger Institute, via EurekAlert (free) AND CDC Seeks to Standardize Mild TBI Management in Kids – MedPage Today (free registration required) AND New advice on kids’ concussions calls for better tracking – Associated Press (free) AND CDC issues first guidelines to treat youth concussions – CNN (free)

 

3 – Screening for Syphilis Infection in Pregnant Women: US Preventive Services Task Force Reaffirmation Recommendation Statement – JAMA (free)

Editorial: Congenital Syphilis—Still a Shadow on the Land (free)

“The USPSTF recommends early screening for syphilis infection in all pregnant women. (A recommendation)”

 

4 – Experts brace for more super-resistant gonorrhea – CIDRAP (free)

 

5 – Perspective: Good Documentation – JAMA (free for a limited period)

“In this narrative medicine essay, the author, who transitioned from paper and pen to computer-generated electronic health record keeping wonders whether the self-select menu items ultimately dehumanizes both the patient and the physician.” (via @JAMA_current see Tweet)

 

6 – Margaret McCartney: A summary of four and a half years of columns in one column – The BMJ (free) (via @oncology_bg)

 

7 – 2018 Korean Clinical Imaging Guideline for Hemoptysis – Korean Journal of Radiology (free)

 

8 – Policy Statement: Child Passenger Safety – American Academy of Pediatrics (free)

News Release: AAP Updates Recommendations on Car Seats for Children (free)

Commentary: Children Should Remain in Rear-Facing Car Seats as Long as Possible – Physician’s First Watch (free)

 

9 – Worldwide trends in insufficient physical activity from 2001 to 2016: a pooled analysis of 358 population-based surveys with 1·9 million participants – The Lancet Global Health (free)

Commentaries: Quarter of world’s population ‘not active enough to stay healthy’ – The Guardian (free) AND A quarter of adults are too inactive, putting health at risk – Reuters (free)

 

10 – Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Physician Burnout Poses Risks to Patient Safety – Psychiatric News Alert (free) AND Burnout in doctors doubles risk of patient safety incidents, study finds – Pulse (free)

 


 

1 – Guideline Summary: Medicines for Treatment Intensification in Type 2 Diabetes and Type of Insulin in Type 1 and Type 2 Diabetes in Low-Resource Settings: Synopsis of the World Health Organization Guidelines on Second- and Third-Line Medicines and Type of Insulin for the Control of Blood Glucose Levels in Nonpregnant Adults With Diabetes Mellitus – Annals of Internal Medicine (free)

Original Guideline: Guidelines on second-and third-line medicines and type of insulin for the control of blood glucose levels in non-pregnant adults with diabetes mellitus – World Health Organization (free PDF)

 

2 – Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus – The Journal of Rheumatology (free PDF)

Related Guidelines: The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (PANLAR) – Annals of Rheumatic Diseases (free)

 

3 – The use of faecal microbiota transplant as treatment for recurrent or refractory Clostridium difficile infection and other potential indications: joint British Society of Gastroenterology (BSG) and Healthcare Infection Society (HIS) guidelines – GUT (free)

 

4 – Perspective: Five of the scariest antibiotic-resistant bacteria in the past five years – The Conversation (free)

 

5 – Review: Hypertensive Disorders of Pregnancy and Future Maternal Cardiovascular Risk – Journal of the American Heart Association (free)

 

6 – Review: Ischemia and No Obstructive Coronary Artery Disease (INOCA): What Is the Risk – Journal of the American Heart Association? (free)

 

7 – Ann Robinson’s research reviews, 3 September 2018 – The BMJ Opinion (free)

 

8 – Primary antifungal prophylaxis for cryptococcal disease in HIV‐positive people – Cochrane Library (free for a limited period)

Summary: Preventing cryptococcal disease in HIV-positive people – Cochrane Library (free)

Antifungal prophylaxis reduced the risk of developing and dying from cryptococcal disease. Therefore, where CrAG screening is not available, antifungal prophylaxis may be used in patients with low CD4 counts at diagnosis and who are at risk of developing cryptococcal disease.”

 

9 – Performance of Electronic Prediction Rules for Prevalent Delirium at Hospital Admission – JAMA Network Open (free)

Commentary: New prediction rule may help detect delirium at hospital admission – ACP Hospitalist (free)

 

10 – Strategy of endovascular versus open repair for patients with clinical diagnosis of ruptured abdominal aortic aneurysm: the IMPROVE RCT – Health Technology Assessment (free)

Commentary: Endovascular aortic repair (EVAR) surgery more beneficial for ruptured abdominal aortic aneurysms than open repair – NIHR Signal (free)

 


 

1 – Consensus document of the Italian Association of Medical Oncology and the Italian Society of Palliative Care on early palliative care – Tumori Journal (free PDF)

Related Video: Early Palliative Care: a video for health and care professionals – University of Edinburgh (free)

Related Systematic Review: Early palliative care for adults with advanced cancer – Cochrane Library (free) AND Summary: Early palliative care for adults with advanced cancer – Cochrane Library (free)

Related guideline: Integration of Palliative Care Into Standard Oncology Care: American Society of Clinical Oncology Clinical Practice Guideline Update (free)

 

2 – Podcast: #111: Hotcakes – Complementary Medicine in Cancer, Dosing Aspirin by Body Weight, Marijuana & Respiratory Symptoms, Penicillin Allergies and More! – The Curbsiders (free audio and summary)

 

3 – Review: Cardiorenal Syndrome Revisited – Circulation (free) (via @Abraham_RMI)

 

4 – “So, Blood Cultures… or No?” – Use of Blood Cultures in the ED – emDocs (free)

Related Review: How to Optimize the Use of Blood Cultures for the Diagnosis of Bloodstream Infections? A State-of-the Art – Frontiers in Microbiology (free)

 

5 – Government proposes energy drinks ban for children – BBC (free)

Related: England Proposes Ban on Selling Energy Drinks to Children – The New York Times (10 articles per month are free)

 

6 – Abraar Karan: Changing the way we communicate about patients – The BMJ Opinion (free) (via @NUNESDOC)

“Father of 2, retired car salesman and keen on football NOT the colon cancer in Bed 4 – social history brings humanity back to the bedside” (via @hospicedoctor see Tweet)

 

7 – American Epilepsy Society: Five Things Physicians and Patients Should Question – Choosing Wisely (free)

Commentary: Choosing Wisely: 5 Practices to Question When Treating Epilepsy – NEJM Physician’s First Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

8 – Antidepressants for treating depression in dementia – Cochrane Library (free for a limited period)

Summary: Antidepressants for treating depression in dementia – Cochrane Library (free)

“On the only measure of efficacy for which we had high-quality evidence (depression rating scale scores), antidepressants showed little or no effect.”

 

9 – The impact of exposure to air pollution on cognitive performance – Proceedings of the National Academies of Sciences (link to abstract – $ for full-text)

Commentaries: Air pollution could be making us less intelligent – Science Magazine (free) AND Air Pollution Exposure Harms Cognitive Performance, Study Finds – NPR (free) AND Air pollution may harm cognitive intelligence, study says – BBC (free) AND Pollution May Dim Thinking Skills, Study in China Suggests – New York Times (10 articles per month are (free) AND Air pollution is making you less intelligent, according to a new study – World Economic Forum (free)

 

10 – Kawasaki disease: guidelines of the Italian Society of Pediatrics, part I – definition, epidemiology, etiopathogenesis, clinical expression and management of the acute phase – Italian Journal of Pediatrics (free)

Part II: Treatment of resistant forms and cardiovascular complications, follow-up, lifestyle and prevention of cardiovascular risks (free)

Related guideline: Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association (free)

Related reviews: Dissecting Kawasaki disease: a state-of-the-art review – European Journal of Pediatrics (free) AND Diagnosis and Management of Kawasaki Disease – American Family Physician (free) AND Controversies in diagnosis and management of Kawasaki disease – World Journal of Clinical Pediatrics (free)

 


 

1 – ESC Council on hypertension position document on the management of hypertensive emergencies – European Heart Journal – Cardiovascular Pharmacotherapy (free) (@Abraham_RMI)

“Patients that lack acute hypertension-mediated end organ damage to the heart, retina, brain, kidneys, or large arteries do not have a hypertensive emergency and can be treated with oral BP-lowering agents and usually discharged after a brief period of observation.”

 

2 – ERS/EACTS statement on the management of malignant pleural effusions – European Respiratory Journal (free)

 

3 – Guideline for the management of hip and knee osteoarthritis – Royal Australian College of General Practitioners (free PDF)

News Release: Updated osteoarthritis guideline designed to reduce unnecessary imaging and surgery (free)

Commentary: Australia hopes to reduce unnecessary imaging, surgery with updated osteoarthritis guidelines – Health Imaging (free)

“The Guideline for the management of knee and hip osteoarthritis,” offer up exercise and weight loss as a first line defense, and warn against costly treatments using glucosamine, opioids and arthroscopic surgery, said David Hunter, co-chair of the RACGP group responsible for the update.” (from Health Imaging)

 

4 – Opinion: Is one drink per day really unsafe? That new alcohol study, explained – VOX (free)

Related Commentary: Study Causes Splash, but Here’s Why You Should Stay Calm on Alcohol’s Risks – The New York Times (10 articles per month are free)

Original Article: Alcohol Use and Burden for 195 Countries and Territories (free study and commentaries)

 

5 – Earwax, Of All Things, Poses Unrecognized Risk In Long-Term Care – Kaiser Health News (free)

“Of all the indignities that come with aging, excessive earwax may be the most insidious… when it goes unrecognized, it can pose serious problems, especially for the 2.2 million people who live in U.S. nursing homes and assisted living centers.”

 

6 – #ESCCongress – Early Versus Standard Care Invasive Examination and Treatment of Patients with Non-ST-Segment Elevation Acute Coronary Syndrome: The VERDICT (Very EaRly vs Deferred Invasive evaluation using Computerized Tomography) – Randomized Controlled Trial – Circulation (free PDF)

Editorial: Timing of Intervention in Non ST Elevation Acute Coronary Syndromes: And the VERDICT is? (free PDF)

Commentaries: VERDICT: Very Early Invasive Coronary Angiography vs. Standard Care in NSTE-ACS Patients- American College of Cardiology (free) AND ESC: Early Invasive Strategy in NSTEMI Does Not Improve Outcomes – MedPage Today (free registration required) AND VERDICT: Very Early Invasive Angiography No Help Overall for NSTE ACS – TCTMD (free)

 

7 – #ESCCongress – Non-invasive detection of coronary inflammation using computed tomography and prediction of residual cardiovascular risk (the CRISP CT study): a post-hoc analysis of prospective outcome data – The Lancet (free)

Commentaries: Imaging of coronary inflammation for cardiovascular risk prediction – The Lancet (free) AND New Imaging Biomarker of Coronary Inflammation Shows Prognostic Value Exceeding All Current Noninvasive Measures – Cleveland Clinic (free) AND Imaging biomarker can predict coronary inflammation – UPI (free)

 

8 – #ESCCongress – Radial versus femoral access and bivalirudin versus unfractionated heparin in invasively managed patients with acute coronary syndrome (MATRIX): final 1-year results of a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: MATRIX: 1-Year Results Confirm Superiority of Transradial PCI – TCTMD (free) AND Radial vs. Femoral Access for Angiography with or Without Bivalirudin in Patients with Acute Coronary Syndrome – NEJM Journal Watch (free for a limited period) AND ESC: Radial Access Tied to Better 1-Year Outcomes in ACS – MedPage Today (free registration required)

 

9 – #ESCCongress – Psychological Distress and Risk of Myocardial Infarction and Stroke in the 45 and Up Study: A Prospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Distress boosts heart attack and stroke risk – Medical News Today (free) AND High Mental Distress Tied to Heart Troubles – MedPage Today (free registration required)

 

10 – #ESCCongress – Deep forehead wrinkles may signal a higher risk for cardiovascular mortality – ESC Press Releases (free)

Commentaries: Forehead wrinkles – an early sign of cardiovascular disease? – Medical News Today (free) AND Excessive forehead wrinkles may be early sign of atherosclerosis – Cardiovascular Business (free)

 


 

1 – Assessment of the genetic and clinical determinants of fracture risk: genome wide association and mendelian randomisation study – The BMJ (free)

Commentaries: Vitamin D: a pseudo-vitamin for a pseudo-disease – The Conversation (free) AND Fracture risk not linked to low vitamin D or calcium levels – OnMedica (free)

Related: Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It (free commentaries and NICE Guideline)

 

2 – Bacterial Factors That Predict Relapse after Tuberculosis Therapy – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Bacterial Factors That Predict Relapse after Antituberculosis Therapy – NEJM Resident 360 (free) AND MICs of Isoniazid, Rifampin May Predict Tuberculosis Relapse – Drugs.com (free) AND Variation in bacterial drug susceptibility tied to TB relapse risk – CHEST Physician (free)

 

3 – Revisiting the timetable of tuberculosis – The BMJ (free)

Related: Soumya Swaminathan: TB programmes should focus on people with highest risk of progression to disease – The BMJ Opinion (free)

 

4 – Clinical Decisions: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome – New England Journal of Medicine (free)

 

5 – 2018 STD Prevention Conference – Centers for Disease Control and Prevention (free)

Press Release: New CDC analysis shows steep and sustained increases in STDs in recent years (free)

Commentaries: 5 reasons why 3 STDs are roaring back in America – VOX (free) AND Rates of three STDs in US reach record high, CDC says – CNN (free) AND Record High Number Of STD Infections In U.S., As Prevention Funding Declines – NPR (free) AND STD cases in U.S. hit record highs as officials warn about resistant gonorrhea – STAT (free) AND US sees record STD cases, rising gonorrhea resistance – CIDRAP (free)

 

6 – Clinical Implications and Challenges of Artificial Intelligence and Deep Learning – JAMA (free for a limited period)

Related Viewpoints: Deep Learning—A Technology With the Potential to Transform Health Care – JAMA (free for a limited period) AND Deep Learning—A Technology With the Potential to Transform Health Care – JAMA (free for a limited period)

 

7 – Publication: Immigration as a Social Determinant of Health: Proceedings of a Workshop – National Academies of Sciences, Engineering, and Medicine (free PDF)

“Immigration as a social determinant of health – NEW publication explores complex interactions between immigration and health disparities + grappling with the complexities of immigration” (via @julianmfisher see Tweet)

 

8 – Optimal Blood Pressure Target in Diabetic and Nondiabetic Hypertensive Patients – Circulation Research (free)

See counterpoint suggesting lower BP targets: Sprinting Toward the Optimal Blood Pressure Target for Hypertensive Patients – Circulation Research (free)

“We have reviewed the randomized trial evidence in favor of a target blood pressure (BP) around 130/80 mm Hg in hypertensive patients with and without diabetes mellitus”

 

9 – Environmental toxic metal contaminants and risk of cardiovascular disease: systematic review and meta-analysis – The BMJ (free)

Editorial: Environmental metals and cardiovascular disease (free)

Commentary: Experts warn of cardiovascular risk from heavy metal pollution – University of Cambridge (free)

“Since metals are associated with cardiovascular disease even at relatively low levels of exposure, population wide strategies to minimize exposure can further contribute to overall cardiovascular prevention efforts” (from @bmj_latest see Tweet)

 

10 – Functional Status and Survival After Breast Cancer Surgery in Nursing Home Residents – JAMA Surgery (free for a limited period)

Commentaries: Surgical Decision Making in Elderly, Impaired Nursing Home Patients – JAMA Surgery (free for a limited period) AND For Nursing Home Patients, Breast Cancer Surgery May Do More Harm Than Good – Kaiser Health News (free)

 


 

1 – Report: Crossing the Global Quality Chasm: Improving Health Care Worldwide – National Academies Of Sciences, Engineering, and Medicine (free PDF)

News Release: Up to 8 Million Deaths Occur in Low- and Middle-Income Countries Yearly Due to Poor-Quality Health Care, Says New Report; Major Quality Chasm Must Be Fixed in Order to Reap Benefits of Universal Health Coverage (free)

Videos: The Scope of the Problem (free) AND Health Systems of the Future (free)

See also: Report Highlights (free PDF) AND Recommendations (free PDF)

 

2 – #ESCCongress – Partial Oral versus Intravenous Antibiotic Treatment of Endocarditis – New England Journal of Medicine (free for a limited period)

Commentaries: Partial Oral Treatment of Endocarditis – POET – American College of Cardiology (free) AND New treatment can halve hospital stays for some patients with heart infection – ESC Press Releases (free)

 

3 – #ESCCongress – High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial – The Lancet (free)

Commentaries: Diagnosing myocardial infarction: a highly sensitive issue – The Lancet (free) AND Hs-TnI in Suspected ACS: High-STEACS Trial – American College of Cardiology (free)

Introduction of a high-sensitivity cardiac troponin I assay reclassified 1 in 6 patients with previously undetected myocardial necrosis, but did not lead to improved clinical outcomes in this large randomised trial” (via @chapdoc1 see Tweet)

Very important study. What’s weird is that the “better” (more sensitive) troponin assays get, the less helpful the test becomes at the bedside. Look for a coming tsunami of iatrogenesis from overzealous evaluation of troponin bumps.” (via @drjohnm see Tweet)

 

4 – #ESCCongress – One-Year Outcomes after PCI Strategies in Cardiogenic Shock – New England Journal of Medicine (free for a limited period)

Commentaries: Less Is Still More in Patients with Acute Myocardial Infarction and Cardiogenic Shock – NEJM Journal Watch (free for a limited period) AND 1-year outcomes still support culprit-only PCI for cardiogenic shock – Cardiovascular Business (free) AND CULPRIT-SHOCK: 1-Year Results Continue to Support Culprit-Only PCI for Shock Patients – TCTMD (free)

 

5 – #ESCCongress – Efficacy of telemedical interventional management in patients with heart failure (TIM-HF2): a randomised, controlled, parallel-group, unmasked trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Telemedicine in Heart Failure Patients (TIM-HF2) – American College of Cardiology (free) AND ESC: Telemonitoring of HF Cuts Admissions, Mortality MedPage Today (free registration required)

 

6 – Global Mortality From Firearms, 1990-2016 – JAMA (free for a limited period)

Video Summary: Global Firearm Mortality, 1990-2016 – JAMA (free)

Infographic: Firearm deaths around the world 1990–2016 – Institute for Health Metrics and Evaluation (free) (via @kleachkemon)

Commentaries: Six countries in the Americas account for half of all firearm deaths – Institute for Health Metrics and Evaluation (free) AND Gun-related homicides, suicides kill more people than war, study says – CNN (free)

 

7 – Zackary Berger’s journal reviews, 28 August 2018 – The BMJ Opinion (free)

 

8 – Guide to Statistics and Methods: Case-Control Studies: Using “Real-world” Evidence to Assess Association – JAMA (free for a limited period)

 

9 – Guiding Principles for the Care of People With or at Risk for Diabetes – National Institute of Diabetes and Digestive and Kidney Diseases (free PDF)

Commentaries: NIDDK Updates ‘Guiding Principles’ for Diabetes, Prediabetes – Medscape (free registration required) AND NDEP revises principles for managing diabetes, prediabetes – Cardiovascular Business (free)

Related Book: Diabetes in America, 3rd Edition – National Institutes of Health (free reference book, just released)

 

10 – Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015 – Nature Human Behavior (free for a limited period)

Commentaries: More social science studies just failed to replicate. Here’s why this is good – VOX (free) AND High-profile journals put to reproducibility test – Nature News (free) AND ‘Replication crisis’ spurs reforms in how science studies are done – ScienceNews (free) AND The Science Behind Social Science Gets Shaken Up—Again – WIRED (Free) AND In Psychology And Other Social Sciences, Many Studies Fail The Reproducibility Test – NPR (free)

We replicated 21 social science experiments in Science or Nature. We succeeded with 13. Replication effect sizes were half of originals.” (via @BrianNosek see Tweet)

 


 

1 – Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal (free)

Commentaries: Care coordination improves health of older patients with multiple chronic diseases – CMAJ, via EurekAlert (free) AND Seniors healthier when medical care is coordinated – Reuters (free)

Related: Ten Recommendations: Designing a High-Performing Health Care System for Patients with Complex Needs (free Guidance and related perspectives) AND Multimorbidity: A Priority for Global Health Research (free research and commentaries)

 

2 – A Simple, Evidence-Based Approach to Help Guide Diagnosis of Heart Failure With Preserved Ejection Fraction – Circulation (free) (via @CircAHA see Tweet with Infographic)

Editorial: H2FPEF Score: At Last, a Properly Validated Diagnostic Algorithm for Heart Failure With Preserved Ejection Fraction (free)

 

3 – Clinical Guideline Synopsis: Diagnosis and Treatment of Clostridium difficile Infection – JAMA (free for a limited period) (via @ABsteward and @Abraham_RMI)

Original Guideline: Clinical Practice Guidelines for Clostridium difficileInfection in Adults and Children: 2017 Update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA) – Clinical Infectious Diseases (free)

 

4 – Review: Acute Clinical Care for Transgender Patients – JAMA Internal Medicine (free for a limited period) (via @CarlosdelRio7)

 

5 – Antithrombotic Therapy for Atrial Fibrillation: CHEST Guideline and Expert Panel Report (free PDF)

News Release: The American College of Chest Physicians updates their antithrombotic therapy guidelines for patients with atrial fibrillation (free)

 

6 – Clinical Report: Marijuana Use During Pregnancy and Breastfeeding: Implications for Neonatal and Childhood Outcomes – Pediatrics (free)

News Release: Counsel against marijuana use in pregnancy, breastfeeding – American Academy of Pediatrics (free)

Related Article: Marijuana Use by Breastfeeding Mothers and Cannabinoid Concentrations in Breast Milk – Pediatrics (free)

Commentaries: A Modern Conundrum for the Pediatrician: The Safety of Breast Milk and the Cannabis-Using Mother – Pediatrics (free) AND Marijuana study finds THC in breast milk up to 6 days after mom’s use – CNN (free) AND Pediatricians Put It Bluntly: Motherhood And Marijuana Don’t Mix – Kaiser Health News (free) AND Clinical report provides guidance on marijuana use in pregnancy and lactation – 2 Minute Medicine (free)

 

7 – #ESCCongress – Effects of n−3 Fatty Acid Supplements in Diabetes Mellitus – New England Journal of Medicine (free for a limited period)

Commentaries: Fish oils do not prevent heart attack or strokes in people with diabetes – ESC News Releases (free) AND Omega-3 Fatty Acids Fail to Reduce CVD Events in Diabetic Patients: ASCEND – TCTMD (free)

Related Cochrane Review: Omega-3 fatty Acids for the Prevention of Cardiovascular Disease (link to abstract and commentaries)

Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free study and commentary)

 

8 – #ESCCongress – Cardiovascular Safety of Lorcaserin in Overweight or Obese Patients – New England Journal of Medicine (free for a limited period)

Editorial: Lorcaserin — Elixir or Liability? (free for a limited period)

Commentaries: CAMELLIA-TIMI 61: Weight Loss Drug Lorcaserin Did Not Increase CV Events – American College of Cardiology (free) AND Weight-Loss Drug Lorcaserin Clears Cardiovascular Safety Hurdle: CAMELLIA-TIMI 61 – TCTMD (free) AND Weight loss drug lorcaserin found safe in large study – Reuters (free)

 

9 – #ESCCongress – Rivaroxaban for Thromboprophylaxis after Hospitalization for Medical Illness – New England Journal of Medicine (free for a limited period)

Commentaries: VTE risk unchanged by rivaroxaban after discharge – The Hospitalist (free) AND MARINER: Rivaroxaban vs. Placebo Post-Discharge in Patients at High Risk For VTE – American College of Cardiology (free) AND MARINER: No Reduction in Death, VTE With Rivaroxaban After Discharge in Medically Ill Patients – Medscape (free registration required)

 

10 – #ESCCongress – Tafamidis Treatment for Patients with Transthyretin Amyloid Cardiomyopathy – New England Journal of Medicine (free for a limited period)

Editorial: Stabilizing Transthyretin to Treat ATTR Cardiomyopathy (free for a limited period)

Commentaries: Tafamidis, a Transthyretin Stabilizer, Offers Hope for Rare Cardiomyopathy – TCTMD (free) AND ATTR-ACT: Tafamidis Findings Offer Hope For Patients With ATTR-CM – American College of Cardiology (free) AND Drug reduces deaths and hospitalizations from underdiagnosed form of heart failure – Columbia University Irving Medical Center, via EurekAlert (free)

 


 

#ESCCongress – Highlights from the 2018 Meeting of the European Society of Cardiology

 

 

1 – #ESCCongress – 2018 ESC/ESH Guidelines for the management of arterial hypertension – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

2 – #ESCCongress – 2018 ESC/EACTS Guidelines on myocardial revascularization – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

3 – #ESCCongress – Fourth universal definition of myocardial infarction (2018) – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

4 – #ESCCongress – 2018 ESC Guidelines for the management of cardiovascular diseases during pregnancy – European Heart Journal (free) (via @escardio see Tweet with Key Infographics)

 

5 – #ESCCongress – Recommendations for participation in competitive sports of athletes with arterial hypertension: a position statement from the sports cardiology section of the European Association of Preventive Cardiology (EAPC) – European Heart Journal (free)

 

6 – #ESCCongress – Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery – New England Journal of Medicine (free for a limited period)

In moderate-to-high-risk patients undergoing cardiac surgery, six-month outcomes show that a restrictive red-cell transfusion strategy is noninferior to a liberal strategy” (via @NEJM see Tweet with Visual Abstract)

 

7 – #ESCCongress – CLARIFY: No Survival Benefit With Beta-Blockers Beyond 1 Year Post-MI in Stable CAD – TCTMD (free)

Related Study: B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction (free study and commentary)

“The problem, said Sorbets, is that there have never been large randomized trials to test the prognostic effects of beta-blockers in this patient group and instead, recommendations have been drawn from meta-analyses using data extracted from the acute MI setting or from observational studies.”

 

8 – #ESCCongress – Coronary CT Angiography and 5-Year Risk of Myocardial Infarction – New England Journal of Medicine (free for a limited period)

Commentary: Five Reasons I Don’t Believe an Imaging Test Improves Outcomes – by Dr. John Mandrola, in Medscape (free registration required)

See also an interesting Tweetorial by @AnilMakam, also suggesting caution before adopting this study results in clinical practice.

 

9 – #ESCCongress – Effects of Aspirin for Primary Prevention in Persons with Diabetes Mellitus – New England Journal of Medicine (free for a limited period)

Commentaries: Bleeds and benefit with aspirin balanced in patients with diabetes and no effect on cancer – ESC Press Releases (free) AND  ASCEND: Aspirin Doesn’t Look Good for Primary CV Prevention in Diabetic Patients – TCTMD (free)

 

10 – #ESCCongress – Use of aspirin to reduce risk of initial vascular events in patients at moderate risk of cardiovascular disease (ARRIVE): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Aspirin Fails to Prevent CV Events in People at ‘Moderate’ Risk of Disease: ARRIVE – TCTMD (free) AND ARRIVE: New Findings Contribute to Growing Body of Evidence Surrounding Aspirin Use – American College of Cardiology (free) AND Daily Aspirin Fails to Lower CV Risk in Long-term, Primary Prevention ARRIVE Trial – Medscape (free registration required) AND Jury still out on aspirin a day to prevent heart attack and stroke – ESC Press Releases (free)

 


 

1 – Alcohol use and burden for 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet (free)

Commentaries: No level of alcohol consumption improves health – The Lancet (free) AND No amount of alcohol is good for your overall health, global study says – CNN (free) AND New scientific study: no safe level of alcohol – Institute for Health Metrics and Evaluation (free)

“Alcohol was responsible for nearly 3 million deaths in 2016, the study says. It was the leading risk factor for disease and premature death in men and women between the ages of 15 and 49 worldwide in 2016, accounting for nearly one in 10 deaths.” (from @cnni see Tweet)

 

2 – Antibiotics should not be issued as first line of treatment for a cough, says NICE and PHE – NICE News and Features (free)

Commentaries: Promote honey rather than antibiotics for coughs, doctors told – The Guardian (free) AND Use honey first for a cough, new guidelines say – BBC (free)

Related: Honey for acute cough in children – Cochrane Library (free systematic review and commentary)

 

3 – How scientists are learning to predict your future with your genes – VOX (free) (via @EricTopol)

There’s not one light switch but hundreds, each with the ability to slightly increase or decrease the chances of developing the illness.”

 

4 – Perspective: Adolescents’ Use of “Pod Mod” E-Cigarettes — Urgent Concerns – New England Journal of Medicine (free)

 

5 – A Late-Life Surprise: Taking Care Of Frail, Aging Parents – Kaiser Health News (free)

 

6 – Viewpoint: The Challenge of Reforming Nutritional Epidemiologic Research – JAMA (free)

“…the emerging picture of nutritional epidemiology is difficult to reconcile with good scientific principles. The field needs radical reform.”

 

7 – Review: Difficult tracheal intubation in critically ill – Journal of Intensive Care (free)

 

8 – Glucocorticoids for croup in children – Cochrane Library (free for a limited period)

Summary: Glucocorticoids for croup in children – Cochrane Library (free)

Commentary: Glucocorticoid Therapy Examined in Pediatric Patients With Croup – MPR (free)

 

9 – Risk of Esophageal Adenocarcinoma After Antireflux Surgery in Patients With Gastroesophageal Reflux Disease in the Nordic Countries – JAMA Oncology (free for a limited period)

 

10 – Association of Cardiovascular Health Level in Older Age With Cognitive Decline and Incident Dementia – JAMA (link to abstract – $ for full-text)

Commentaries: Study confirms that keeping the heart healthy also reduces dementia risk – NHS Choices (free) AND The Healthier Your Heart, the Healthier Your Brain May Be – The New York Times (10 articles per month are free) AND Cardiovascular Risk Factors Also Linked to Dementia – MedicalResearch.com (free) AND Reducing CV Risk May Improve Brain Health at Any Stage in Life, Studies Hint – TCTMD (free)

 


 

1 – Screening for Cervical Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Related articles: Screening for Cervical Cancer With High-Risk Human Papillomavirus Testing: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA (free) AND Screening for Cervical Cancer in Primary Care: A Decision Analysis for the US Preventive Services Task Force – JAMA (free)

Editorials: Screening for Cervical Cancer: New Tools and New Opportunities (free for a limited period) AND Cervical Cancer Screening—Moving From the Value of Evidence to the Evidence of Value (free for a limited period)

Author Interview: USPSTF Recommendation: Screening for Cervical Cancer (free)

Final Update Summary: Cervical Cancer: Screening – US Preventive Service Task Force (free)

Commentaries: Cervical cancer screening without Pap test OK for some women – Reuters (free) AND For Cervical Cancer Screening, Women Over 30 Can Now Choose The HPV Test Only – NPR (free) AND Annual Pap Test a ‘Thing of the Past?’ – Florida Atlantic University (free)

 

2 – Joint Consensus Document: Management of antithrombotic therapy in AF patients presenting with ACS and/or undergoing PCI – European Heart Journal (free)

 

3 – CSI position statement on management of heart failure in India – Indian Heart Journal (free)

 

4 – 2017 WSES guidelines on colon and rectal cancer emergencies: obstruction and perforation – World Journal of Emergency Surgery (free)

 

5 – The Japanese Clinical Practice Guideline for acute kidney injury 2016 – Journal of Intensive Care (free)

 

6 – Our first year together – World Health Organization (free)

“Delighted to share my first annual letter as WHO Director-General. It outlines our major achievements over the past year and what I believe are the keys to achieving #HealthForAll. I’m proud of everything we’ve achieved – but we’re just getting started!” (via @DrTedros see Tweet)

 

7 – How smartphones are becoming a weapon in the global fight against tuberculosis – STAT (free)

 

8 – Long-Term Association of Low-Density Lipoprotein Cholesterol With Cardiovascular Mortality in Individuals at Low 10-Year Risk of Atherosclerotic Cardiovascular Disease – Circulation (free)

Commentaries: ‘Bad’ cholesterol can be deadly in otherwise healthy people – AHA News (free) AND LDL >160 Tied to Increased Mortality in Low-Risk Patients – Physician’s First Watch (free) AND Study: Elevated LDL, non-HDL increase CVD mortality risk in young, healthy individuals – Cardiovascular Business (free) AND Moderate ‘bad cholesterol’ levels tied to early death for healthy people – Reuters (free)

 

9 – Effect of procalcitonin-guided antibiotic treatment on clinical outcomes in intensive care unit patients with infection and sepsis patients: a patient-level meta-analysis of randomized trials – Critical Care (free)

Commentary: Procalcitonin guidance linked to improved sepsis survival – Univadis (free registration required)

 

10 – Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Pregabalin may increase the risk of death when coprescribed with opioids – 2 Minute Medicine (free) AND Pregabalin Linked To Increased Risk for Opioid-Related Deaths – MedicalResearch.com (free) AND Anticonvulsant With Opioids Tied To Higher Mortality – MedPage Today (free registration required)

 


 

1 – Podcast: #109: Things We Do For No Reason: A High Value Episode – The Curbsiders (free audio and summary)

Related Series: Choosing Wisely: Things We Do For No Reason – Journal of Hospital Medicine (some free articles)

 

2 – Perspective: Outbreaks in a Rapidly Changing Central Africa — Lessons from Ebola – New England Journal of Medicine (free)

Related: Experimental Ebola treatments OK’d in DRC as cases top 100 – CIDRAP (free) AND Congo approves more experimental Ebola treatments as cases rise – Reuters (free)

 

3 – Sport Specialization and Risk of Overuse Injuries: A Systematic Review With Meta-analysis – Pediatrics (link to abstract – $ for full-text)

Commentary: Sport specialization tied to injuries in kids and teens – Reuters (free)

 

4 – Asthma and COPD Overlap in Women: Incidence and Risk Factors – Annals of the American Thoracic Society (link to abstract – $ for full-text)

Commentaries: More than 40 percent of women with asthma may develop COPD, but risk may be reduced – Annals of Thoracic Society (free) AND Four in 10 women with asthma may develop COPD – Reuters (free) AND Four in 10 women with asthma may develop COPD – OnMedica (free)

 

5 – Perspective: Exploring the Relationship Between Depression and Dementia – JAMA (free for a limited period)

 

6 – Association Between Electronic Cigarette Use and Myocardial Infarction – American Journal of Preventive Medicine (free for a limited period)

Commentary: Risk of heart attacks is double for daily e-cigarette users – University of California – San Francisco, via ScienceDaily (free)

“New analysis shows five-fold risk for people who use both cigarettes and e-cigarettes daily”

 

7 – Phosphate binders for preventing and treating chronic kidney disease‐mineral and bone disorder (CKD‐MBD) – Cochrane Library (free for a limited period)

Summary: Phosphate binders to prevent complications of chronic kidney disease – Cochrane Library (free)

 

8 – Extended antibiotic infusions could save lives: Here’s how to do it – PulmCCM (free)

Related Research: Mortality lower with prolonged vs. short-term IV infusion of antipseudomonal beta-lactams (free)

The simplest (and cheapest) technique is simply to reduce the time between doses.”

 

9 – Seven days of antibiotics were as good as 14 for gram-negative bacteremia – PulmCCM (free)

Related Commentary: Seven-day antibiotic course delivers similar outcomes to 14-days for Gram-negative bacteraemia – European Society of Clinical Microbiology and Infectious Diseases, via EurekAlert (free)

“It’s important to note that source control was believed to be achieved in all enrolled patients. If source control cannot be achieved (e.g., an abscess, or an infected heart valve or indwelling catheter that cannot safely be removed), prolonged antibiotic courses are often advisable.”

 

10 – Breastfeeding History and Risk of Stroke Among Parous Postmenopausal Women in the Women’s Health Initiative – Journal of the American Heart Association (free)

Commentaries: Breastfeeding linked to lower stroke risk – Reuters (free) AND Breastfeeding may help protect mothers against stroke – AHA News (free)

“…ultimately, the study is observational, which means that it can only prove that breastfeeding is associated with lower risk of stroke as opposed to being the cause of the lowered risk.” (from Reuters)

 


 

1 – Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management: A Scientific Statement From the American Heart Association – Circulation (free PDF)

AHA News Release: Chagas disease, caused by a parasite, has spread outside of Latin America and carries a high risk of heart disease (free)

Top Ten Things to Know: Chagas Cardiomyopathy: An Update of Current Clinical Knowledge and Management (free PDF)

 

2 – Clinical Report: The Power of Play: A Pediatric Role in Enhancing Development in Young Children – Pediatrics (free)

News Release: Want Creative, Curious, Healthier Children with 21st Century Skills? Let Them Play – American Academy of Pediatrics (free)

Commentary: It’s come to this: A checkup with the pediatrician may soon include a prescription for play – Los Angeles Times (free) AND Let Kids Play – The New York Times (10 articles per month are free) AND AAP Report Highlights Importance of Children’s Play for Development – Journal Watch (free)

 

3 – Rapid Communication: Key changes to treatment of multidrug- and rifampicin-resistant tuberculosis (MDR/RR-TB) – World Health Organization (free PDF)

News Release: WHO announces landmark changes in MDR-TB treatment regimens (free)

Commentary: WHO revises MDR-TB treatment with focus on oral drugs – CIDRAP (free)

 

4 – Measles cases hit record high in the European Region – World Health Organization (free)

Commentaries: Measles cases hit record high in Europe – BBC (free) AND Expert reaction to measles cases in Europe – Science Media Centre (free) AND Low MMR uptake blamed for surge in measles cases across Europe – The Guardian (free) AND Measles cases reach record high in Europe – CNN (free)

 

5 – Assessment of the Safety of Discharging Select Patients Directly Home From the Intensive Care Unit: A Multicenter Population-Based Cohort Study – JAMA Internal Medicine (free for a limited period)

Invited Commentary: The Complexity and Challenges of Intensive Care Unit Admissions and Discharges: Similarities With All Hospitalized Patients – JAMA Internal Medicine (free for a limited period)

 

6 – Clinical Update: Management of Groin Hernias in Adults—2018 – JAMA (free for a limited period)

 

7 – Perspective: This Drug Is Safe and Effective. Wait. Compared With What? – The New York Times (10 articles per month are free)

 

8 – Rotavirus Vaccination and the Global Burden of Rotavirus Diarrhea Among Children Younger Than 5 Years – JAMA Pediatrics (free)

“Rotavirus-associated mortality has decreased by 48.2% in children under 5 between 1990 and 2016” (via @IHME_UW see Tweet with infographics)

 

9 – Optimising first- and second-line treatment strategies for untreated major depressive disorder — the SUND study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial – BMC Medicine (free)

 

10 – Clinical chemistry score versus high-sensitivity cardiac troponin I and T tests alone to identify patients at low or high risk for myocardial infarction or death at presentation to the emergency department – Canadian Medical Association Journal (free)

Commentaries: Simple score to diagnose heart attacks is safer, faster than current methods – McMaster University (free) AND Clinical Chemistry Score Helps Rule Out Diagnosis of Heart Attack – MedicalResearch.com (free)

 


 

1 – Oral steroids for resolution of otitis media with effusion in children (OSTRICH): a double-blinded, placebo-controlled randomised trial – The Lancet (free)

Invited commentary: Helping children with hearing loss from otitis media with effusion – The Lancet (free)

“Short-course oral prednisolone is not an effective treatment for most children aged 2–8 years with persistent otitis media with effusion but is well tolerated—findings from OSTRICH, the first placebo-controlled trial” (via @TheLancet see Tweet)

 

2 – Report: E-Cigarettes – House of Commons Science and Technology Committee (free PDF)

Commentaries: Stop treating e-cigs like conventional cigarettes, MPs tell NHS – OnMedica (free) AND E-cigarettes can be key weapon against smoking, say MPs – BBC (free)

See also: related guidelines, reports and commentaries on e-cigarettes (all free)

 

3 – Corticosteroids in Sepsis: An Updated Systematic Review and Meta-Analysis – Critical Care Medicine (free)

Related: Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)

 

4 – Vitamin D, the Sunshine Supplement, Has Shadowy Money Behind It – The New York Times (10 articles per month are free) (via @CarlosdelRio7 see Tweet)

Related commentaries: Vitamin D Screening and Supplementation in Primary Care: Time to Curb Our Enthusiasm – American Family Physician (free) AND Your vitamin D tests and supplements are probably a waste of money – VOX (free) AND Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

Related Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (free)

“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk” (from NICE Guideline)

 

5 – Too Much Medicine: A small medical conference with a big impact – HealthNewsReview (free)

 

6 – Review: Intravenous fluid therapy in critically ill adults – Nature Reviews Nephrology (free for a limited period) (via @CritCareReviews)

 

7 – Review: Airway and ventilation management during cardiopulmonary resuscitation and after successful resuscitation – Critical Care (free)

 

8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentaries: WHO Expects Ebola To Spread In Congo In Areas Too Dangerous To Send Workers – NPR (free) AND Health worker among 5 new cases in DRC Ebola outbreak – CIDRAP (free) AND Militia threat hampers Ebola fight in Congo as disease kills 47 – Reuters (free)

 

9 – Association of Body Mass Index With Blood Pressure Among 1.7 Million Chinese Adults – JAMA Network Open (free)

Commentary: As body mass index increases, blood pressure may as well – Yale University (free)

 

10 – Dietary carbohydrate intake and mortality: a prospective cohort study and meta-analysis – The Lancet Public Health (free)

Commentaries: Evolving evidence about diet and health – The Lancet Public Health (free) AND Expert reaction to study looking at carbohydrate intake and health – Science Media Centre (free) AND Moderate carbohydrate intake may be best for health, study suggests – The Lancet, via ScienceDaily (free) AND Low-carb diets could shorten life, study suggests – BBC (free)

 


 

1 – 2018 AHA/ACC Guideline for the Management of Adults With Congenital Heart Disease (free PDF)

News Release: Societies Release Updated Guideline for Treating Adult Congenital Heart Disease Patients (free)

Key Points to Remember: 2018 AHA/ACC Guideline for Adults With Congenital Heart Disease – American College of Cardiology (free)

 

2 – Clinical Practice Guidelines for the Prevention and Management of Pain, Agitation/Sedation, Delirium, Immobility, and Sleep Disruption in Adult Patients in the ICU – Critical Care Medicine (free) (via @Abraham_RMI)

 

3 – Association of Compensation From the Surgical and Medical Device Industry to Physicians and Self-declared Conflict of Interest – JAMA Surgery (free for a limited period)

Author Interview: Association of Compensation to Physicians From Industry and Self-declared Conflict of Interest (free)

Commentaries: Safeguarding Against Conflicts of Interest in the Surgical Literature – JAMA Surgery (free for a limited period) AND Financial Ties That Bind: Studies Often Fall Short On Conflict-Of-Interest Disclosures – Kaiser Health News (free)

 

4 – Recent trends in life expectancy across high income countries: retrospective observational study – The BMJ (free)

Editorial: Reversals in life expectancy in high income countries? (free for a limited period)

Commentaries: Life Expectancy Declining Across High Income Countries – Eurasia Review (free) AND Australians living longer but life expectancy dips in US and UK – The Guardian (free) AND UK life expectancy drops while other western countries improve – NHS Choices (free)

 

5 – Changes in midlife death rates across racial and ethnic groups in the United States: systematic analysis of vital statistics – The BMJ (free)

Infographic: Why is US Life Expectancy Falling Behind? (free PDF)

Commentary: Life expectancy drops in the US and the UK, rises in Australia, a new study finds – CNN (free)

 

6 – Keeping Up With Cardiology: Old-School Learning Versus the Twittersphere – TCTMD (free)

Related: Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free) AND Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

 

7 – Effect of Peer Comparison Letters for High-Volume Primary Care Prescribers of Quetiapine in Older and Disabled Adults: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Behavioral nudges lead to striking drop in prescriptions of potent antipsychotic – Columbia University’s Mailman School of Public Health, via ScienceDaily (free) AND Study Reduces Over-prescription of Antipsychotics in Older Adults – Mad in America (free) AND ‘Dear Doctor’ Letters Use Peer Pressure, Government Warning To Stop Overprescribing – NPR (free) AND Peer Pressure Tactic Successfully Curbs Overprescribing – Medscape (free registration required)

 

8 – Smoking Cessation, Weight Change, Type 2 Diabetes, and Mortality – The New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Weight gain after smoking cessation linked with increased short-term diabetes risk – Harvard T.H. Chan School of Public Health (free) AND Weight gain temporarily hikes diabetes risk when smokers quit – Reuters (free) AND Smokers Are Better Off After They Quit Even if They Gain Weight – Physician’s First Watch (free)

 

9 – Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free for a limited period)

Summary: Endovascular coiling versus neurosurgical clipping for people with aneurysmal subarachnoid haemorrhage – Cochrane Library (free)

 

10 – Association of Maternal Insecticide Levels With Autism in Offspring From a National Birth Cohort – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Autism and DDT: What one million pregnancies can — and can’t — reveal – Nature News (free) AND Epidemiologists Link DDT From The 1970s To Modern Autism Diagnoses – Science 2.0 (free – skeptical point of view on study results)

 


 

1 – Risk Factors, Mortality, and Cardiovascular Outcomes in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: In Type 2 Diabetes, Five Risk Factor Targets Keep MI, Stroke, and Death in Check – TCTMD (free) AND How People With Type 2 Diabetes Can Lower Their Risk of Health Problems – TIME (free) AND T2D, Without Other Risks, Not Tied to Excess Mortality – MedPage Today (free registration required)

 

2 – Absolute risk and predictors of the growth of acute spontaneous intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data – The Lancet Neurology (free)

Commentary: Brain scan checklist set to boost care for stroke survivors – University of Edinburgh, via EurekAlert (free)

 

3 – Trends in Use of Daily Chest Radiographs Among US Adults Receiving Mechanical Ventilation – JAMA Network Open (free)

Commentaries: Daily Chest X-Rays Still Overused in Mechanically Ventilated Patients – MedicalResearch.com (free) AND Routine daily CXRs for ventilated patients: de-adoption is lagging – Univadis (free registration required) AND Chest x-rays overused on ventilation patients despite ACR guideline – HealthImaging (free)

 

4 – Editorial: Making diagnostic tests as essential as medicines – BMJ Global Health (free)

Related: Report: First-ever WHO List of Essential Diagnostic Tests (free report and news release) AND The WHO Essential Diagnostic List: A Tool for the Future (free commentaries)

 

5 – How Unpaywall is transforming open science – Nature News (free)

Related: Unlocking paywalled research papers (legally) (free commentaries) AND Half of papers searched for online are free to read (free)

We have been using the Unpaywall Extension for a while, and it is indeed a handy tool to find free versions (entirely legal) of paywalled articles.

 

6 – Long-Term Prognosis of Patients With Takotsubo Syndrome – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Long-Term Prognosis of Takotsubo Syndrome – American College of Cardiology (free) AND How deadly is Takotsubo syndrome? It depends on the trigger – Cardiovascular Business (free)

Related: International Expert Consensus Document on Takotsubo Syndrome (free)

 

7 – Perspective: Medical students are skipping class in droves — and making lectures increasingly obsolete – STAT (free)

 

8 – Ebola virus disease in the Democratic Republic of the Congo – Operational readiness and preparedness in neighbouring countries – World Health Organization (free)

Related: WHO chief calls for end to fighting in Congo to halt Ebola spread – The Guardian (free) AND Ebola cases mounting in DRC as region prepares for more – CIDRAP (free)

 

9 – Association Between Traumatic Brain Injury and Risk of Suicide – JAMA (link to abstract – $ for full-text)

Commentaries: Traumatic brain injury tied to increased risk of suicide – Reuters (free) AND Risk of Suicide Increases After TBI, Study Finds – Psychiatric News Alert (free) AND Expert reaction to traumatic brain injury and suicide – Science Media Centre (free)

 

10 – Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Switching Anti-Psychotic Medications Doesn’t Improve Outcomes in First-Episode Schizophrenia Patients – Mount Sinai (free) AND No Benefit of Switching Antipsychotics in Early Schizophrenia – Medscape (free registration required) AND No Gain with Antipsych Meds Switch in Schizophrenia – MedPage Today (free registration required)

 


 

1 – State of the Art Review: Overdiagnosis in primary care: framing the problem and finding solutions – The BMJ (free for two weeks)

 

2 – Genome-wide polygenic scores for common diseases identify individuals with risk equivalent to monogenic mutations – Nature Genetics (link to abstract – $ for full-text)

Commentaries: Researchers predict risk for common deadly diseases from millions of genetic variants – Broad Institute of MIT and Harvard, ScienceDaily (free) AND Clues to Your Health Are Hidden at 6.6 Million Spots in Your DNA – The New York Times (10 articles per month are free) AND Multi-gene test may find risk for heart disease and more – Associated Press (free) AND A Harvard Scientist Thinks He Has a Gene Test for Heart Attack Risk. He Wants to Give It Away Free – Forbes (free)

  

3 – Fixed Low-Dose Triple Combination Antihypertensive Medication vs Usual Care for Blood Pressure Control in Patients With Mild to Moderate Hypertension in Sri Lanka: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video Summary: Fixed-Dose Combination Pill for Hypertension Treatment in Sri Lanka (free)

Commentaries: Three-in-one pill lowers blood pressure significantly, study say – UPI (free) AND Innovative triple pill significantly lowers blood pressure, study finds – George Institute for Global Health, via EurekAlert (free)

 

4 – Richard Smith: The polypill and the long journey to major impact – The BMJ Opinion (free)

Related Reviews: Strengths and Limitations of Using the Polypill in Cardiovascular Prevention – Current Cardiology Reports (free) AND The polypill approach – An innovative strategy to improve cardiovascular health in Europe – BMC Pharmacology and Toxicology (free)

 

5 – Cancer in People Living with HIV – NCCN Clinical Practice Guidelines in Oncology – Journal of the National Cancer Center Network (free)

 

6 – Opinion: Lessons for physicians from ‘The Bleeding Edge’: If you see something, say something – STAT (free)

“…physicians must act decisively when they identify the rare outlier in their midst. To do anything less would risk our credibility. Worse still, it could risk the lives of the people we took an oath not to harm.”

 

7 – Yoga, Depression, & Clinical Trial Critique 101 – Hilda Bastian, in Absolutely Maybe Blog (free)

“5 steps to unpack a randomized trial!” (via @hildabast, see Tweet)

 

8 – DRC Ebola cases surpass earlier outbreak total, virus infects 4 more health workers – CIDRAP (free)

Related: DRC may provide model for containing future Ebola outbreaks – The Conversation (free)

 

9 – Book: Diabetes in America, 3rd Edition – National Institutes of Health (free chapters)

News Release: New NIH reference book is one-stop resource for diabetes medical information – National Institutes of Health (free)

 

10 – Treatments for women with gestational diabetes mellitus: an overview of Cochrane systematic reviews – Cochrane Library (free)

Summary: Treatments to improve pregnancy outcomes for women who develop diabetes during pregnancy: an overview of Cochrane systematic reviews – Cochrane Library (free)

 


 

1 – Clinically applicable deep learning for diagnosis and referral in retinal disease – Nature Medicine (free for a limited period)

Commentaries: Opening the ‘black box,’ Google DeepMind AI system diagnoses eye diseases and shows its work – STAT (free) AND Artificial intelligence tool ‘as good as experts’ at detecting eye problems – The Guardian (free)

 

2 – Automated deep-neural-network surveillance of cranial images for acute neurologic events – Nature Medicine (free for a limited period)

Commentaries: Artificial Intelligence Platform Screens for Acute Neurological Illnesses at Mount Sinai – Mount Sinai Health System, via NewsWise (free) AND AI diagnoses neurological diseases on CT in 1.2 seconds – Health Imaging (free) AND New AI system can screen for neurological illnesses in seconds – UPI (free)

 

3 – Screening for Urinary Incontinence in Women: A Recommendation From the Women’s Preventive Services Initiative – Annals of Internal Medicine (free)

Commentaries: WPSI says screen all women annually for urinary incontinence – American College of Physicians, via EurekAlert (free)

 

4 – Diagnosis of Invasive Fungal Diseases in Haematology and Oncology. 2018 Update of the Recommendations of the Infectious Diseases Working Party of the German Society for Hematology and Medical Oncology (AGIHO) – Mycosis (free PDF)

 

5 – American Academy of Family Physicians: Twenty Things Physicians and Patients Should Question (free)

Commentary: Choosing Wisely: New Practices to Avoid in Family Medicine – NEJM Journal Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

6 – Analysis of clinical benefit, harms, and cost-effectiveness of screening women for abdominal aortic aneurysm – The Lancet (free)

Commentaries: Should we screen women for abdominal aortic aneurysm? – The Lancet (free) AND Cost-Effectiveness of Screening Women for AAA – American College of Cardiology (free) AND Women Likely Not Good Targets for AAA Screening, Study Suggests – TCTMD (free)

 

7 – Prevalence and Estimated Economic Burden of Substandard and Falsified Medicines in Low- and Middle-Income Countries: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: Prevalence of Substandard and Falsified Essential Medicines: Still an Incomplete Picture – JAMA Network Open (free) AND New Study Finds Fake, Low-Quality Medicines Prevalent in the Developing World – University of North Carolina at Chapel Hill, via R&D (free)

 

8 – Evaluating Shared Decision Making for Lung Cancer Screening – JAMA Internal Medicine (free for a limited period)

Editorial: Failing Grade for Shared Decision Making for Lung Cancer Screening (free for a limited period)

Author Interview: Evaluating Shared Decision Making for Lung Cancer Screening (free audio)

Commentaries: Doctors may not explain pros, cons of lung cancer screening – Reuters (free) AND Shared Decision-Making Flops for Lung Ca Screening – MedPage Today (free registration required)

 

9 – Perspective: Surrogate End Points Ain’t all that Bad – The Health Care Blog (free) (via @RogueRad)

 

10 – Excess mortality and cardiovascular disease in young adults with type 1 diabetes in relation to age at onset: a nationwide, register-based cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Early type 1 diabetes shortens women’s lives by 18 years – University of Gothenburg, via ScienceDaily (free) AND Early age type 1 diabetes linked to shorter life expectancy than later age diagnosis – OnMedica (free)

 


 

1 – Corticosteroid therapy for sepsis: a clinical practice guideline – The BMJ (free)

 

2 – Outbreaks: Behind the headlines – World Health Organization (free)

 

3 – Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction – JAMA Network Open (free)

Commentaries: Algorithm IDs Patients at Risk of Post-MI Events – MedPage Today (free registration required) AND Risk Model Helps Predict CV Events 1 Year After Acute MI – Medscape (free registration required)

 

4 – Analysis: Renaming low risk conditions labelled as cancer – The BMJ (free for a limited period)

Commentaries: Is it time to remove the cancer label from low-risk conditions? – The Conversation (free) AND Doctors should avoid saying ‘cancer’ for minor lesions – study – The Guardian (free) Drop ‘cancer’ label to protect patients from over-treatment, researchers say – The Sidney Morning Herald (free)

 

5 – Review: Dos and Don’ts in the Management of Cirrhosis: A View from the 21st Century – American Journal of Gastroenterology (via @Abraham_RMI)

 

6 – The multivitamin industry rakes in billions of dollars. But science says we’re not getting healthier – by Timothy Caulfield, in NBC News THINK (free)

Related Study: Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free) AND Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)

“Unless you have a clinically identified deficiency, the research tells us there is little reason to consume supplements.”

 

7 – Tick- and Mosquito-Borne Diseases Are Increasing Dramatically – Scientific American (free)

Related: CDC Report: U.S Trends in Vector-borne Diseases (link to report and commentaries)

 

8 – Infographic: High burden, low budget: non-communicable diseases in low- and middle-income countries – Institute for Health Metrics and Evaluation (free) (via @equitylist)

 

9 – Multifactorial and multiple component interventions for preventing falls in older people living in the community – Cochrane Library (free)

Summary: Featured Review: Multifactorial and multiple component interventions for preventing falls in older people living in the community – Cochrane Library (free)

 

10 – Analysis of the Global Burden of Disease study highlights the global, regional, and national trends of chronic kidney disease epidemiology from 1990 to 2016 – Kidney International (free)

News release and visual abstract: KI article shows the doubling incidence, prevalence and mortality of CKD – International Society of Nephrology (free)

Commentary: Global Burden of Kidney Disease on the Rise, Unequally Distributed – Medscape (free registration required)

 


 

1 – Dietary Diversity: Implications for Obesity Prevention in Adult Populations: A Science Advisory From the American Heart Association – Circulation (free PDF)

News Release: A diverse diet may not be the healthiest one (free)

Commentary: Diet Recommendations for Obesity Prevention: Time to Ditch Diversity (free)

Top Ten Things to Know: Dietary Diversity: Implications for Obesity Prevention in Adult Populations (free PDF)

 

2 – Opioid prescribing decreases after learning of a patient’s fatal overdose – Science (free for a limited period)

Commentary: Notification of patient overdose deaths reduces clinician opioid prescriptions – NIH News Releases (free) AND Clinicians were told their patient had died of an overdose. Then opioid prescribing dropped – STAT (free)

 

3 – Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis – The Lancet Psychiatry (free)

Commentaries: Refining treatment choices for ADHD – The Lancet Psychiatry (free) AND ADHD medications: Of all available drugs, methylphenidate should be first option for short-term treatment in children – ScienceDaily (free) AND Analysis of ADHD Drugs: Use Methylphenidate in Kids, Amphetamines in Adults – Physician’s First Watch (free)

Related: Cochrane Review: Adverse Events of Methylphenidate for ADHD in Children and Adolescents (link to abstract and free summary) AND Short Review: Stimulants for ADHD in children (free) AND Opinion: Drug treatment of ADHD – tenuous scientific basis (free)

 

4 – Viewpoint: Clinical Practice Guidelines: What’s Next? – JAMA (free for a limited period)

 

5 – Urinary sodium excretion, blood pressure, cardiovascular disease, and mortality: a community-level prospective epidemiological cohort study – The Lancet (link to abstract – $ for full-text)

Commentary: Lancet Paper Adds To Evidence That Reducing Salt To Very Low Levels May Be Dangerous – CardioBrief (free)

Related Report: Salt intake and Cardiovascular Disease (free report and commentaries)

 

6 – Are the “Best Buys” for Alcohol Control Still Valid? An Update on the Comparative Cost-Effectiveness of Alcohol Control Strategies at the Global Level – Journal of Studies on Alcohol and Drugs (free)

Commentary: Higher alcohol taxes are cost-effective in reducing alcohol harms – ScienceDaily (free)

Related: To improve global health, tax the things that are killing us – Financial Times (free policies, articles and commentaries) AND Policy lessons from health taxes (free research and commentaries)

 

7 – Nonsurgical Treatments for Urinary Incontinence in Women: A Systematic Review Update – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF)

 

8 – Scaled deployment of Wolbachia to protect the community from Aedes transmitted arboviruses – Gates Open Research (free)

Commentary: Dengue rates plummet in Australian city after release of modified mosquitoes – Nature News (free)

 

9 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: DRC probes more suspected Ebola cases, rules out 3 – CIDRAP (free) AND War zone complicates roll-out of Ebola vaccine in latest outbreak – Nature News (free)

 

10 – Association of Endometrial Cancer Risk With Postmenopausal Bleeding in Women: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: How common is endometrial cancer in women with postmenopausal bleeding? – eCancer News (free) AND Postmenopausal Bleeding: Reliable Sign of Endometrial Cancer – Medscape (free registration required)

 


 

1 – Practice guideline update recommendations summary: Disorders of consciousness – American Academy of Neurology (free PDF)

Related: Ethical, palliative, and policy considerations in disorders of consciousness – Neurology (free PDF) AND Comprehensive systematic review update summary: Disorders of consciousness – Neurology (free PDF)

Commentaries: New Guideline Released for Managing Vegetative and Minimally Conscious States – American Academy of Neurology, via NewsWise (free) AND Groups Issue New Disorders of Consciousness Guidelines – MedPage Today (free registration required)

 

2 – Labor Induction versus Expectant Management in Low-Risk Nulliparous Women – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Labor Induction versus Expectant Management in Low-Risk Women (free)

Commentaries: Induced labor at 39 weeks may reduce likelihood of C-section, NIH study suggests – NIH News Releases (free) AND Pregnancy Debate Revisited: To Induce Labor, Or Not? – NPR (free)

 

3 – Vitamin D Supplementation in Pregnancy and Lactation and Infant Growth – New England Journal of Medicine (free)

Commentary: Maternal Vitamin D Supplementation Doesn’t Improve Infant Growth – Physician’s First Watch (free)

 

4 – Outcomes of Cardiac Screening in Adolescent Soccer Players – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Footballer heart death risk ‘underestimated’ – BBC (free) AND No Easy Answers on Best Heart Check-Up for Young Athletes – Associated Press, via NYT (free)

 

5 – Would technology enabled remote consulting save time and add value in primary care? – The BMJ Opinion (free)

“Would remote consulting save time and add value in primary care? Rising multimorbidity makes the evaluation of potentially time saving technologies ever more necessary” (via @bmj_latest see Tweet)

 

6 – Treatment for Bipolar Disorder in Adults: A Systematic Review – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF) AND Evidence Summary (free PDF)

 

7 – WHO MERS Global Summary and Assessment of Risk – World Health Organization (free PDF)

Commentary: WHO highlights ongoing hospital MERS outbreak threat – CIDRAP (free)

 

8 – Perspective: Addressing Barriers to Inclusion of Pregnant Women in Clinical Trials – JAMA (free for a limited period)

 

9 – Publication bias: The answer to your research question may be sitting in somebody’s file drawer – Students 4 Best Evidence (free)

Related: Bias in medical research: A glossary of common research biases – First10Em (free) Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

 

10 – Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Expert reaction to physical activity linked to improved mental health – Science Media Centre (free) AND Regular exercise ‘best for mental health’ – BBC (free) AND Exercise is good for your body and your mind, study says – CNN (free)

 


 

1 – Screening for Atrial Fibrillation With Electrocardiography: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Atrial Fibrillation Comes With Many Snags (free for a limited period) AND Electrocardiography Screening for Atrial Fibrillation: We Can Do Better (free for a limited period)

Author Interview: USPSTF Recommendation: Screening for Atrial Fibrillation With Electrocardiography (free audio)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of screening for atrial fibrillation with ECG. (I statement)”

 

2 – Mortality effects of timing alternatives for hip fracture surgery – Canadian Medical Association Journal (free)

Commentaries: Lower death rate when senior hip fractures are repaired quickly – Reuters (free) AND Delayed surgery for hip fractures cause of preventable deaths, study finds – The Globe and Mail (free) AND The sun should not set twice before hip fracture repair – CMAJ, via ScienceDaily (free)

 

3 – Update: Interim Guidance for Preconception Counseling and Prevention of Sexual Transmission of Zika Virus for Men with Possible Zika Virus Exposure — United States, August 2018 – CDC, MMWR (free)

Related: Vital Signs: Zika-Associated Birth Defects and Neurodevelopmental Abnormalities Possibly Associated with Congenital Zika Virus Infection — U.S. Territories and Freely Associated States, 2018 – CDC, MMWR (free)

Commentaries: 1 in 7 kids exposed to Zika in utero suffers defects, delays – CIDRAP (free) AND 1 in 7 babies exposed to Zika in the womb have health problems, CDC reports – STAT (free) AND One in 7 babies prenatally exposed to Zika has health problems, CDC says – CNN (free)

 

4 – Corticosteroid use and intensive care unit-acquired weakness: a systematic review and meta-analysis – Critical Care (free)

 

5 – The use of viscoelastic haemostatic assays in the management of major bleeding: A British Society for Haematology Guideline – British Journal of Haematology (free)

Source: Critical Care Reviews Newsletter

 

6 – Perspective: Workplace Wellness Programs Don’t Work Well. Why Some Studies Show Otherwise. – The New York Times (10 articles per month are free)

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: July 2018 – eCancer News (free)

 

8 – Cardiotoxicity and Cardiac Monitoring Among Chemotherapy-Treated Breast Cancer Patients – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

Commentaries: Prioritize cardiac monitoring for high-risk breast cancer patients, study suggests – ACP Internist (free) AND Cardiac monitoring may benefit high-risk breast cancer patients against heart failure – Cardiovascular Business (free) AND After Cardiotoxic Chemo, Less Than Half of Women With Breast Cancer Get Recommended Monitoring – TCTMD (free) AND Study Shows Importance of Cardiac Monitoring in High-Risk Breast Cancer Patients – American College of Cardiology (free)

 

9 – Special Issue: Roles of Physicians in Healthy Dying- AMA Journal of Ethics (free articles)

“What the roles of clinicians and patients should be in defining what constitutes a quality dying experience and good care of dying people has received less attention than issues like euthanasia and assisted death. Which parts of dying, if any, should be medicalized and why? What do patients and clinicians need to know about dying and why? The August 2018 issue of the AMA Journal of Ethics explores these and other questions.”

 

10 – Twelve-Month Outcomes After Transplant of Hepatitis C–Infected Kidneys Into Uninfected Recipients: A Single-Group Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Patients who accepted infected kidneys cured of hepatitis C – STAT (free) AND Good Outcomes for HCV-Negative Recipients of HCV Kidneys – Renal & Urology News (free)

 


 

1 – Sedentary Behaviors in Today’s Youth: Approaches to the Prevention and Management of Childhood Obesity: A Scientific Statement From the American Heart Association – Circulation (free PDF)

News release: New tools, old rules: limit screen-based recreational media at home – AHA/ASA Newsroom (free)

 

2 – Primary Biliary Cholangitis: 2018 Practice Guidance from the American Association for the Study of Liver Diseases – Hepatology (free)

 

3 – AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2018 – German Gynecological Oncology Group (free)

 

4 – AGO Recommendations for the Diagnosis and Treatment of Patients with Advanced and Metastatic Breast Cancer: Update 2018 – German Gynecological Oncology Group (free)

 

5 – Patient–physician gender concordance and increased mortality among female heart attack patients – PNAS (link to abstract – $ for full-text)

Commentaries: Women More Likely to Survive Heart Attacks If Treated by Female Doctors – The Atlantic (free) AND Women survive a heart attack more often when their doctor is female, study finds – STAT (free) AND Women survive heart attacks better with women doctors – Washington University in St. Louis, via ScienceDaily (free)

 

6 – Review: Oxygen Treatment in Intensive Care and Emergency Medicine – Deutsches Ärzteblatt International (free)

 

7 – Review: Liver enzymes: No trivial elevations, even if asymptomatic – Cleveland Clinic Journal of Medicine (free)

 

8 – Opinion: Anti-Vaccine Activists Have Taken Vaccine Science Hostage – The New York Times (10 articles per month are free)

“Should researchers not publish findings when there’s a chance they might be misinterpreted and scare the public?” (via @NYTHealth see Tweet)

 

9 – Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews – Cochrane Library (link to abstract – $ for full-text)

Summary: An overview of Cochrane Reviews on red blood cell transfusions to treat or prevent sickle cell disease-related complications – Cochrane Library (free)

 

10 – Microvascular Outcomes in Patients With Diabetes After Bariatric Surgery Versus Usual Care: A Matched Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Bariatric Surgery for Diabetes May Halve the Risk for Microvascular Disease – NEJM Physician’s First Watch (free) AND Bariatric surgery linked to significant reduction in microvascular complications of type 2 diabetes – MedicalXpress (free)

 


 

1 – Delirium in adult cancer patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

2 – Comparison of Clinical Outcomes Among Patients With Atrial Fibrillation or Atrial Flutter Stratified by CHA2DS2-VASc Score – JAMA Network Open (free)

Commentaries: Ischemic Stroke Risk Scoring May Not Be Accurate for Patients with Atrial Flutter – TCTMD (free) AND Don’t Group Afib, Atrial Flutter Together in Evaluating Stroke Risk – MedPage Today (free registration required)

 

3 – The Surviving Sepsis Campaign: A Rush to Judgment – NEJM Journal Watch (free)

Original Guideline: The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)

Related Opinion: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free)

 

4 – Playing Doctor with Watson: Medical Applications Expose Current Limits of AI – Spiegel (free) (via @EricTopol)

“IBM has big plans for how its Watson artificial intelligence software could change the medical industry. But a number of hospitals have ended their experiments with the platform, arguing that it doesn’t help diagnose or treat diseases.”

 

5 – Bias in medical research: A glossary of common research biases – First10Em (free) (via @pash22)

Related: Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

 

6 – The Illness Is Bad Enough. The Hospital May Be Even Worse – The New York Times (10 articles per month are free)

Related: Post-Hospital Syndrome — An Acquired, Transient Condition of Generalized Risk – New England Journal of Medicine (free) AND Is Posthospital Syndrome a Result of Hospitalization-Induced Allostatic Overload? – Journal of Hospital Medicine (free) (via @hmkyale)

“The elderly are particularly vulnerable to “post-hospital syndrome,” some experts believe, and that may be why so many patients return.”

 

7 – Quantifying excess deaths related to heatwaves under climate change scenarios: A multicountry time series modelling study – PLOS Medicine (free)

Commentaries: Heatwave deaths will rise steadily by 2080 as globe warms up – Monash University, via ScienceDaily (free) AND Heatwave deaths likely to rise steadily by 2080 without appropriate climate and health policies – London School of Hygiene & Tropical Medicine (free)

Related Lancet Editorial: Heatwaves and health (free)

Related Report: Lancet Countdown: Traking Progress on Health and Climate Change (free report, commentaries, infographics, video and other resources)

 

8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: Conflict in new Ebola zone of DR Congo exacerbates complexity of response: WHO emergency response chief – UN News (free) AND WHO: Ebola DRC outbreak taking place in ‘war zone’ – CIDRAP (free) AND Ebola In A Conflict Zone – NPR (free) AND WHO sees complex vaccine and security questions in Ebola response – Reuters (free)

 

9 – Colloids versus crystalloids for fluid resuscitation in critically ill people – Cochrane Library (link to abstract – $ for full-text)

Summary: Colloids or crystalloids for fluid replacement in critically people – Cochrane Library (free)

Using starches, dextrans, albumin or FFP (moderate-certainty evidence), or gelatins (low-certainty evidence), versus crystalloids probably makes little or no difference to mortality. Starches probably slightly increase the need for blood transfusion and RRT (moderate-certainty evidence), and albumin or FFP may make little or no difference to the need for renal replacement therapy (low-certainty evidence)”.

 

10 – Peer-supported self-management for people discharged from a mental health crisis team: a randomised controlled trial – The Lancet (free)

Commentaries: Peer-delivered self-management programmes in mental health – The Lancet (free) AND After the crisis: self-management and peer-support – The Mental Elf (free) AND Peer Support Helps Reduce Mental Crisis Readmissions – MedPage Today (free registration required)

 


 

1 – National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the management of heart failure 2018 – The Medical Journal of Australia (free for 10 days)

 

2 – National Heart Foundation of Australia and Cardiac Society of Australia and New Zealand: Australian clinical guidelines for the diagnosis and management of atrial fibrillation 2018 – The Medical Journal of Australia (free for 10 days)

 

3 – Diagnosis, treatment and prevention of pediatric obesity: consensus position statement of the Italian Society for Pediatric Endocrinology and Diabetology and the Italian Society of Pediatrics – Italian Journal of Pediatrics (free)

 

4 – The Top 10 Pulmonary Pearls for Primary Care Physicians – Mayo Clinic Proceedings (free for a limited period)

 

5 – Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence – Mayo Clinic Proceedings (free for a limited period)

Commentaries: Regular sauna users may have fewer chronic diseases – Reuters (free) AND Saunas Linked to Numerous Health Benefits – Medscape (free registration required) AND Frequent sauna bathing has many health benefits – Elsevier, via ScienceDaily (free)

 

6 – No proof that moderate drinking prevents dementia – NHS Choices (free)

See original study: Alcohol consumption and risk of dementia (free text, editorial and commentaries)

“”Middle aged drinking may reduce dementia risk, new study finds,” is the misleading and irresponsible headline in The Daily Telegraph.”

 

7 – Viewpoint: Lyme Disease in 2018: What Is New (and What Is Not) – JAMA (free for a limited period)

 

8 – ACG Clinical Guideline: Management of Crohn’s Disease in Adults – The American Journal of Gastroenterology (free)

Commentary: New Crohn Disease Management Guidelines: Top Five Takeaways – Medscape (free registration required)

 

9 – Obesity Increases the Duration of Influenza A Virus Shedding in Adults – The Journal of Infectious Diseases (free)

Commentaries: Study suggests obesity may increase flu spread – CIDRAP (free) AND Beyond Disease Severity: The Impact of Obesity on Influenza A Virus Shedding – The Journal of Infectious Diseases (free) AND Study suggests obesity may also impact flu transmission, not just severity of illness – Infectious Diseases Society of America, via EurekAlert (free) AND Obesity extends duration of influenza A virus shedding – NIH News (free)

 

10 – Increasing tolerance of hospital Enterococcus faecium to handwash alcohols – Science Translational Medicine (link to abstract – $ for full-text)

Commentaries: Study finds increased alcohol tolerance in common hospital pathogen – CIDRAP (free) AND Superbugs now also becoming resistant to alcohol disinfectants – Reuters (free) AND Some Bacteria Are Becoming ‘More Tolerant’ Of Hand Sanitizers, Study Finds – NPR (free)

Researchers found that E faecium isolates collected in 2 Australian hospitals after 2009 were 10x more tolerant to alcohol than those collected before 2004, and that the date of isolation was a much better predictor of survival than the genotype” (via @CIDRAP_ASP see Tweet)

 


 

1 – Four Months of Rifampin or Nine Months of Isoniazid for Latent Tuberculosis in Adults – New England Journal of Medicine (free)

Related Article: Safety and Side Effects of Rifampin versus Isoniazid in Children – New England Journal of Medicine (free)

Quick Take Video Summary: Rifampin or Isoniazid for Latent Tuberculosis (free)

Commentaries: New tuberculosis treatment could help tackle global epidemic – The Guardian (free) AND Rifampin Promising for Latent TB in Phase 3 Trials – Medscape (free registration required)

 

2 – Clinical Report: Physician’s Role in Coordinating Care of Hospitalized Children – American Academy of Pediatrics (free)

News Release: Report guides pediatricians in improving care coordination of hospitalized children – AAP News (free)

 

3 – Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Validation of ESC 0/1-h Algorithm for MI – American College of Cardiology (free) AND ESC Algorithm Safely Rules Out NSTEMI, But Caution May Be Warranted in the US – TCTMD (free)

Related Review: High-Sensitivity Cardiac Troponin in the Evaluation of Possible AMI – American College of Cardiology (free)

 

4 – Prospective Randomized Evaluation of Preoperative Angiotensin-Converting Enzyme Inhibition (PREOP-ACEI) – Journal of Hospital Medicine (free)

Commentary: Omitting ACE inhibitor before surgery reduced intraoperative hypotension, study finds – ACP Hospitalist (free)

 

5 – Cluster of presumptive Ebola cases in North Kivu in the Democratic Republic of the Congo – World Health Organization (free)

Commentaries: New Ebola outbreak declared in DRC a week after earlier one declared over – STAT (free) AND DRC confirms new Ebola cluster days after outbreak declared over – CIDRAP (free) AND Congo declares new Ebola outbreak in eastern province – Reuters (free) AND Deadly Ebola Strikes Anew, a Week After Previous Outbreak Was Extinguished – The New York Times (10 articles per month are free)

 

6 – Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline – Neurology (link to abstract – $ for full-text)

Commentary: People who frequently feel dizzy on standing ‘at future risk of dementia’ – NHS Choices (free)

Related Research: Orthostatic hypotension and symptomatic subclinical orthostatic hypotension increase risk of cognitive impairment: an integrated evidence review and analysis of a large older adult hypertensive cohort – European Heart Journal (free)

 

7 – A Consensus Statement on acromegaly therapeutic outcomes – Nature Reviews Endocrinology (free)

Commentary: Consensus statement: optimizing acromegaly management – Univadis (free registration required)

 

8 – Alcohol consumption and risk of dementia: 23 year follow-up of Whitehall II cohort study – The BMJ (free)

Editorial: Relation between alcohol consumption in midlife and dementia in late life (free)

Commentaries: Expert reaction to long term abstinence and heavy drinking associated with dementia – Science Media Centre (free) AND Middle-aged non-drinkers may have ‘higher risk’ of dementia – The Guardian (free)

 

9 – Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis – JAMA Cardiology (free for a limited period)

Author Interview: Efficacy and Safety of Further Lowering of LDL Cholesterol in Patients Starting With Very Low Levels (free)

 

10 – MRI-defined White Matter Microstructural Alteration Associated with Soccer Heading Is More Extensive in Women than Men – Radiology (free for a limited period)

Commentaries: Soccer Heading May Be Riskier for Female Players – RSNA (free) AND Heading May Be Riskier For Female Soccer Players Than Males – NPR (free)

 


 

1 – Report: Capture the moment – Early initiation of breastfeeding: the best start for every newborn – World Health Organization (free)

News Release: 3 in 5 babies not breastfed in the first hour of life (free)

Commentaries: When it comes to breastfeeding, ‘timing is everything’ in saving newborn lives – UNICEF chief – UN News (free) AND 60% of babies ‘at risk due to breastfeeding delay after birth’ – The Guardian (free)

 

2 – Evidence Synopsis: Aspirin Plus Clopidogrel vs Aspirin Alone for Preventing Cardiovascular Events Among Patients at High Risk for Cardiovascular Events – JAMA (free for a limited period)

“Clopidogrel+ASA: Reduced risk for MI and ischemic stroke – Increased risk for major bleeding compared with aspirin alone. Combined therapy is NOT associated with lower mortality.” (via @ehlJAMA see Tweet)

 

3 – Risk factors associated with revision for prosthetic joint infection after hip replacement: a prospective observational cohort study – The Lancet Infectious Diseases (free)

Commentaries: Risk factors in septic revisions following total hip arthroplasty – The Lancet Infectious Diseases (free) AND Several factors associated with hip replacement revision due to prosthetic joint infection – ACP Internist Weekly (free)

 

4 – Choosing Wisely: Society for the Advancement of Blood Management: Five Things Physicians and Patients Should Question (free)

Commentary: Choosing Wisely: Five Anemia, Transfusion Practices to Avoid – Physician’s First Watch (free)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

5 – Perspective: Europe Expanded the “No Elsevier Deal” Zone & This Could Change Everything – Hilda Bastian, in Absolutely Maybe Blog (free)

 

6 – Perspective: Assisted suicide is controversial, but palliative sedation is legal and offers peace – The Washington Post (free)

 

7 – Perspective: A Fear of Lawsuits Really Does Seem to Result in Extra Medical Tests – The New York Times (10 articles per month are free)

“Doctors are known for complaining about how the malpractice system adds costs. But it has been hard to prove, until now.”

 

8 – Review: Differential diagnosis, investigation and therapy of bilateral adrenal incidentalomas – European Journal of Endocrinology (free)

 

9 – Antithrombotic Therapy in Patients With Atrial Fibrillation Treated With Oral Anticoagulation Undergoing Percutaneous Coronary Intervention – Circulation (free)

Commentary: New Consensus Statement: NOAC and Clopidogrel for Most A-fib Patients Treated With PCI – TCTMD (free)

 

10 – Association of Statin Exposure With Histologically Confirmed Idiopathic Inflammatory Myositis in an Australian Population – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Rare Inflammatory Muscle Inflammation Increased With Statin Exposure – MedicalResearch.com (free) AND Statin Associated with an Increase in Inflammatory Myopathy – RheumNow (free) AND Statin use may increase risk for idiopathic inflammatory myositis – Healio (free registration required)

 


 

1 – Guidelines for the care and treatment of persons diagnosed with chronic hepatitis C virus infection – World Health Organization (free)

See also: World Hepatitis Day (28 July 2018) – World Health Organization (free manuals, guidelines and campaign resources)

 

2 – Management of cancer pain in adult patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

3 – Analysis of clinical benefit, harms, and cost-effectiveness of screening women for abdominal aortic aneurysm – The Lancet (free)

Invited Commentary: Should we screen women for abdominal aortic aneurysm? – The Lancet (free)

 

4 – Esomeprazole and aspirin in Barrett’s oesophagus (AspECT): a randomised factorial trial – The Lancet (free)

Invited Commentary: Should aspirin and PPIs be recommended for patients with Barrett’s oesophagus? – The Lancet (free)

 

5 – Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Treating Depression May Improve Cardiac Outcomes, Research Finds – AJMC (free) AND Treating depression may prevent repeat heart attack, study says – UPI (free)

 

6 – Opinion: How Do You Want to Die? – The New York Times (10 articles per month are free)

“Are we turning sudden cardiac death into a longer, winding path? Defibrillators can prevent sudden death but they also can take away the sudden-death option.” (via @RasoiniR see Tweet)

 

7 – Treatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)

Summary: Treatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)

 

8 – Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Protease inhibitors may increase risk of death in people with HIV and heart failure – OnMedica (free) AND Protease inhibitors may increase risk of death in people with HIV and heart failure – Massachusetts General Hospital, via EurekAlert (free)

 

9 – Prevalence of Depression Among Fathers at the Pediatric Well-Child Care Visit – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: New dads need depression screening, too – Reuters (free) AND New Dads as Likely to Suffer From Depression as Moms, Study Suggests – Medscape (free registration required)

 

10 – Pharmacological Treatment of Arterial Hypertension in Children and Adolescents: A Network Meta-Analysis – Hypertension (free)

Commentary: Pediatric hypertension: ACEi/ARBs look like the best choice – Univadis (free)

According to the present analysis, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers could represent the best choice as antihypertensive treatment for pediatric hypertension. However, because of the paucity of available data for the other classes of antihypertensive drugs, definitive conclusions are not allowed and further randomized controlled trials are warranted.”

 


 

1 – Low-Calorie Sweetened Beverages and Cardiometabolic Health: A Science Advisory From the American Heart Association – Circulation (free PDF)

News Release: Limit low-calorie sodas and drinks, and stick to water instead, researchers advise (free)

 

2 – Health Collection: Strategic review of child health – The BMJ (free articles)

“About 5.6m children died before their 5th birthday in 2016. The new global child health collection launching today explores how we can work together to safeguard the health and wellbeing of children across the world.”

 

3 – Guideline: PSA-Based Prostate Cancer Screening in Men Aged 55-69 – American Academy of Family Physicians (free)

News Release: AAFP Updates Its PSA Screening Recommendation (free)

Related Guidelines with conflicting viewpoints: American Cancer Society Guideline for the Early Detection of Prostate Cancer (free) AND USPSTF Recommendation Statement: Screening for Prostate Cancer (free guideline, editorial and commentaries)

 

4 – The association between suicide deaths and putatively harmful and protective factors in media reports – Canadian Medical Association Journal (free) (via @IrfanDhalla)

Invited Commentary: Responsible reporting to prevent suicide contagion (free for one week)

 

5 – Richard Lehman’s journal reviews, 30 July 2018 – The BMJ Opinion (free)

Richard Lehman’s final review of the latest research in the top medical journals.

 

6 – Viewpoint: Gaps in the Clinical Management of Influenza: A Century Since the 1918 Pandemic – JAMA (free)

 

7 – Counseling in Pediatric Populations at Risk for Infertility and/or Sexual Function Concerns – Pediatrics (free)

News Release: How and when to counsel at-risk patients about fertility preservation, sexual function – AAP News (free)

 

8 – Drinking or Smoking While Breastfeeding and Later Cognition in Children – Pediatrics (free)

Commentaries: Study: Drinking while breastfeeding linked with children’s reasoning deficits – AAP News (free) AND Alcohol in breast milk may lead to lower cognition in kids, study finds – CNN (free) AND Fuel For Mommy Shaming: Breastfeeding And Alcohol Study Deeply Misleading – Forbes (free)

 

9 – LOw dose MAGnesium sulfate versus HIgh dose in the early management of rapid atrial fibrillation: randomised controlled double blind study – Academic Emergency Medicine (link to abstract – $ for full-text)

Commentaries: Low-dose vs. High-dose Magnesium in Rapid Afib – The PharmERToxGuy (free) AND Magnesium to treat rapid Afib in the ED – Univadis (free registration required)

 

10 – A Systematic Review and Meta‐analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department – Academic Emergency Medicine (link to abstract – $ for full-text)

Commentaries: Low-Dose Ketamine Offers Effective Alternative to Opioids in Treatment of Acute Pain, Meta-Analysis Suggests – Psychiatric News Alert (free) AND Ketamine vs Opioids for Acute Pain in the Emergency Department – MedicalResearch.com (free) AND Low-Dose Ketamine May Be a Safe Opioid Alternative, Review Confirms – Medscape (free registration required) AND Ketamine could help reduce opioid use in the ER – Medical News Today (free)

 


 

1 – Medications that reduce emergency hospital admissions: an overview of systematic reviews and prioritisation of treatments – BMC Medicine (free) (via @OxPrimaryCare)

Commentary: The eleven best medications for reducing pressure on emergency care services – University of Oxford (free)

 

2 – First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (PANLAR) – Annals of Rheumatic Diseases (free) (via @Abraham_RMI)

Commentary: Latin American Clinical Practice Guidelines for Lupus – RheumNow (free)

Related Guideline: The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND Executive Summary (free)

 

3 – Fluid therapy in the emergency department: an expert practice review – Emergency Medicine Journal (free)

Related Guidelines: Intravenous fluid therapy in adults in hospital – National Institute for Health and Care Excellence (free) AND Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany – European Journal of Anaesthesiology (free)

Related Reviews: Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy – Annals of Intensive Care (free) AND A rational approach to fluid therapy in sepsis – British Journal of Anaesthesia (free)

Source: Critical Care Reviews Newsletter

 

4 – Timing of intervention in aortic stenosis: a review of current and future strategies – Heart (free)

 

5 – Intensive blood pressure control and ‘dementia’: another mad rush to report incomplete SPRINT findings – HealthNewsReview (free)

See also: No, A Big NIH Trial Did Not Show That Lowering Blood Pressure Will Prevent Dementia – Cardiobrief (free)

 

6 – Opinion: Physicians aren’t ‘burning out.’ They’re suffering from moral injury – STAT (free)

Related: The Burnout Crisis in American Medicine (free commentaries on the subject) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and free commentaries)

 

7 – Choosing Wisely: American Academy of Pediatrics – Section on Nephrology and the American Society of Pediatric Nephrology: Five Things Physicians and Patients Should Question (free)

AAP News Release: Choosing Wisely Offers Advice on Appropriate Nephrology Testing in Children (free)

Commentary: AAP offers guidance on pediatric nephrology tests, procedures – Univadis (free registration required)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UKChoosing Wisely Australia AND Choosing Wisely Canada

 

8 – Mirror therapy for improving motor function after stroke – Cochrane Library (link to abstract – $ for full-text)

Summary: Mirror therapy for improving movement after stroke – Cochrane Library (free)

 

9 – Association of Osteoporosis Medication Use After Hip Fracture With Prevention of Subsequent Nonvertebral Fractures: An Instrumental Variable Analysis – JAMA Network Open (free)

Commentaries: Osteoporosis Treatment After Hip Fracture: Bad News and Getting Worse – JAMA Network Open (free) AND Rate of Osteoporosis Drug Treatment to Prevent Recurrent Fractures Dropping – AJMC (free) AND Osteoporosis treatment often not started after hip fracture in elderly patients, study finds – ACP Internist (free)

 

10 – Is the consumption of fast foods associated with asthma or other allergic diseases? – Respirology (free)

Commentary: Consumption of Fast Food Linked with Asthma and Other Allergic Diseases – Wiley (free) AND Study Links Fast Food Consumption to Severe Asthma – AJMC (free)

 


 

1 – UNDETECTABLE = UNTRANSMITTABLE: Public Health and HIV Viral Load Suppression – UNAIDS Explainer (free PDF)

News Release: Undetectable = Untransmittable – UNAIDS (free)

Related: Science Validates Undetectable = Untransmittable HIV Prevention Message – National Institute of Allergy and Infectious Diseases (free) AND The “Undetectable = Untransmittable” message goes global: I=I, N=N and B=B – Aidsmap (free)

 

2 – Rapid Recommendations: Patent foramen ovale closure, antiplatelet therapy or anticoagulation therapy alone for management of cryptogenic stroke? A clinical practice guideline – The BMJ (free)

 

3 – Diagnosis, treatment and prevention of ankle sprains: update of an evidence-based clinical guideline – British Journal of Sports Medicine (free)

 

4 – Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Giving Plasma to Trauma Patients with Severe Bleeding During Air Transport Saves Lives – Health Sciences at the University of Pittsburgh, via NewsWise (free)

 

5 – EASL Clinical Practice Guidelines for the management of patients with decompensated cirrhosis – Journal of Hepatology (free)

Source: Critical Care Reviews Newsletter

 

6 – Drug Therapy for Early Rheumatoid Arthritis: A Systematic Review Update – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF)

 

7 – Breastfeeding Programs and Policies, Breastfeeding Uptake, and Maternal Health Outcomes in Developed Countries – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF) AND Evidence Summary (free PDF)

 

8 – Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands – JNCI: Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentary: Pediatric CT Scans and Subsequent Malignancy Risk – The ASCO Post (free)

 

9 – Sexual transmission of Zika virus and other flaviviruses: A living systematic review – PLOS Medicine (free) (via @NIAIDNews)

Commentary: Study suggests smaller window for Zika sexual transmission – CIDRAP (free)

 

10 – Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis – JAMA (link to abstract – $ for full-text)

Commentaries: Pediatric sepsis care within an hour increases chances of survival, shows study – News Medical (free) AND “Rory’s Regulations” Improves Pediatric Sepsis Care – MedicalResearch.com (free) AND Sepsis Survival Higher in Kids With Quick Bundle Completion – Medscape (free registration required)

 


 

1 – Antiretroviral Drugs for Treatment and Prevention of HIV Infection in Adults: 2018 Recommendations of the International Antiviral Society–USA Panel – JAMA (free)

Editorial: 2018 IAS-USA Recommendations for the Use of Antiretroviral Therapy for HIV: Building on Decades of Progress (free)

Commentary: International Organization Releases New Guidelines for Treatment and Prevention of HIV Infection in Adults – University of Alabama at Birmingham, via NewsWise (free)

 

2 – Clinical Review Audio: Working on the Precipice: On the Frontlines of the AIDS Epidemic at the CDC, Part I – JAMA (free)

Related Perspective: Anthony Fauci, MD: Working to End HIV/AIDS – JAMA (free)

 

3 – Recommendations for participation in leisure time or competitive sports in athletes-patients with coronary artery disease: a position statement from the Sports Cardiology Section of the European Association of Preventive Cardiology (EAPC) – European Heart Journal (free)

 

4 – A Clinician’s Guide for Trending Cardiovascular Nutrition Controversies: Part II – Journal of the American College of Cardiology (free)

Related – Part I: Trending Cardiovascular Nutrition Controversies – Journal of the American College of Cardiology (free)

Commentary: Chew on This: Review Tackles Controversies in Nutrition for CV Health – TCTMD (free) AND Separating health from hype for a diet that’s kind on your heart – ABC News (free)

 

5 – Ebola outbreak in DRC ends: WHO calls for international efforts to stop other deadly outbreaks in the country – World Health Organization (free)

Commentaries: Deadly Ebola outbreak in Congo is declared over by health ministry – STAT (free) AND Congo declares Ebola flare-up over after rapid response – Reuters (free) AND DRC declares end to Ebola outbreak – CIDRAP (free)

Related: An Ebola Outbreak Has Just Been Stopped. Here’s What It Tells Us About Containing Epidemics – Harvard Business Review (free) AND Ebola: How a killer disease was stopped in its tracks – BBC (free) AND Congo’s Ebola outbreak is all but over. Did an experimental vaccine help? – Science Magazine (free)

 

6 – Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentaries: Flare-up of Ebola in Liberian family highlights virus persistence – CIDRAP (free) AND For the First Time, a Female Ebola Survivor Infects Others – The New York Times (10 article per month are free)

 

7 – Antidepressant Withdrawal Syndrome – Therapeutics Initiative (free)

Related Perspective: Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)

Antidepressants should be added to the list of drugs associated with tolerance, dependence and a withdrawal syndrome.”

“Withdrawal symptoms occur in at least one-third of patients who stop.”

 

8 – Development and validation of a cardiovascular disease risk-prediction model using population health surveys: the Cardiovascular Disease Population Risk Tool (CVDPoRT) – Canadian Medical Association Journal (free)

See also: Heart Attack & Stroke Calculator (free tool)

Commentaries: New health calculator can help predict heart disease risk, estimate heart age – CMAJ, via ScienceDaily (free) AND Calculator can predict heart age, risk for heart disease – UPI (free) AND Algorithm Allows Patients To Calculate Their Risk of Stroke and Heart Disease – MedicalResearch.com (free)

Related Calculators: ACC/AHA CV Risk Calculator (free) AND QRISK3-2017 Cardiovascular Disease Risk Calculator (free)

 

9 – When We Eat, or Don’t Eat, May Be Critical for Health – The New York Times (10 articles per month are free)

Original Article: Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes – Cell Metabolism (link to abstract – $ for full-text)

 

10 – Effect of Intermittent Compared With Continuous Energy Restricted Diet on Glycemic Control in Patients With Type 2 Diabetes: A Randomized Noninferiority Trial – JAMA Network Open (free)

Commentaries: Study: 5:2 diet as effective at controlling diabetes as monitoring daily caloric intake – UPI (free) AND HbA1c improves just as much on dieting only two days a week – OnMedica (free) AND Two-Day Fast Per Week vs Daily Calorie Restriction in Diabetes – MedicalResearch.com (free)

 


 

1 – Canadian Stroke Best Practice Recommendations for Acute Stroke Management: Prehospital, Emergency Department, and Acute Inpatient Stroke Care, 6th Edition, Update 2018 – International Journal of Stroke (free)

 

2 – Canadian Stroke Best Practice Consensus Statement: Acute Stroke Management during pregnancy – International Journal of Stroke (free)

 

3 – Tropical diseases in the ICU: A syndromic approach to diagnosis and treatment – Journal of Critical Care (free)

 

4 – Reports from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine:

– Sepsis in tropical regions

– Intensive care in severe malaria

– Dengue fever

– Ebola virus disease

– Leptospirosis

– Zika virus

– Chikungunya

Source: Critical Care Reviews Newsletter

 

5 – Policy statement: Food Additives and Child Health – American Academy of Pediatrics (free)

Technical Report: Food Additives and Child Health (free)

Commentaries: Chemicals in Food May Harm Children, Pediatricians’ Group Says – The New York Times (10 articles per month are free) AND Pediatrics Group Issues Statement on Food Additives and Child Health – Physician’s First Watch (free) AND Report: Common food additives may pose danger to kids – University of Washington Medicine (free)

 

6 – Honey for cough in children: can it help? – Evidently Cochrane (free)

Original Cochrane Review: Honey for acute cough in children – Cochrane Library (free) AND Summary: Honey for acute cough in children (free)

 

7 – Richard Lehman’s journal reviews, 23 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

8 – Recommendations from the international evidence‐based guideline for the assessment and management of polycystic ovary syndrome – Clinical Endocrinology (free)

 

9 – The 10 fundamental principles of lay resuscitation: Recommendations by the German Resuscitation Council – European Journal of Anaesthesiology (free PDF)

 

10 – Association between maternal adherence to healthy lifestyle practices and risk of obesity in offspring: results from two prospective cohort studies of mother-child pairs in the United States – The BMJ (free)

Commentaries: Mums with healthy habits ‘less likely’ to have obese children – NHS Choices (free) AND Mother’s lifestyle influences child’s obesity risk – Cardiovascular Business (free) AND 5 habits for moms that help prevent childhood obesity – Harvard Medical School (free)

 


 

1 – Guideline: Early and locally advanced breast cancer: diagnosis and management – National Institute for Health and Care Excellence (free)

 

2 – 4th ESO–ESMO International Consensus Guidelines for Advanced Breast Cancer (ABC 4) – Annals of Oncology (free)

 

3 – Blood pressure targets for the treatment of people with hypertension and cardiovascular disease – Cochrane Library (free)

Summary: Blood pressure targets in people with cardiovascular disease – Cochrane Library (free)

Insufficient evidence to justify lower than standard blood pressure targets in people with hypertension + CVD” (via @CochraneHTN see Tweet)

 

4 – Opinion: Paramedic 2: Epinephrine harms/helps in out of hospital cardiac arrest – First10EM (free)

See Also: Original Article (free study and editorial) AND Expert Reaction (free commentaries)

“Paramedic 2 quick summary:

If 1000 people treated with epinephrine:

– 246 extra ROSC (return of spontaneous circulation)

– 158 extra admissions

– 8 extra survivors (5 with bad neuro outcomes, 3 with good neuro outcomes)

– What those numbers mean is a value question, not a science question.” (via @First10EM see Tweet)

 

5 – Guideline: Human Immunodeficiency Virus Drug Resistance: 2018 Recommendations of the International Antiviral Society–USA Panel – Clinical Infectious Diseases (free) (via @CarlosdelRio7)

 

6 – Report: Miles to go—closing gaps, breaking barriers, righting injustices – UNAIDS (free PDF)

Press Release: UNAIDS warns that progress is slowing and time is running out to reach the 2020 HIV targets (free)

Commentary: U.N. says global fight against AIDS is at ‘precarious point’ – Reuters (free)

Source: International Health Policies Newsletter

 

7 – Advancing global health and strengthening the HIV response in the era of the Sustainable Development Goals: the International AIDS Society—Lancet Commission (free articles and commentaries – registration required)

Commentaries: Report Warns Of ‘Dangerous Complacency’ In The Fight Against HIV – NPR (free) AND ‘Dangerous complacency’ to global HIV epidemic risks resurgence – BBC (free) AND Experts warn approach to HIV/AIDS is complacent – OnMedica (free)

 

8 – Burden of disease in Brazil, 1990–2016: a systematic subnational analysis for the Global Burden of Disease Study 2016 – The Lancet (free)

Related Study: The burden of Neglected Tropical Diseases in Brazil, 1990-2016: A subnational analysis from the Global Burden of Disease Study 2016 – PLOS Neglected Tropical Diseases (free)

 

9 – Definitions and pathophysiology of vasoplegic shock – Critical Care (free)

 

10 – Application of enhanced recovery after gastric cancer surgery: An updated meta-analysis – World Journal of Gastroenterology (free)

Commentary: Enhanced recovery programmes after stomach cancer surgery reduce hospital stay without increasing complications – NIHR Signals (free)

See also: Enhanced Recovery After Surgery Guidelines and Reviews (all free)

 


 

1 – Expert reaction to trial looking at adrenaline for cardiac arrests – Science Media Centre (free)

See original article in yesterday’s issue: A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest (see #1)

Related Review: The role of adrenaline in cardiopulmonary resuscitation – Critical Care (free)

 

2 – A Phase 3 Trial of l-Glutamine in Sickle Cell Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Glutamine to Treat Sickle Cell Disease (free)

Commentary: Drug may ease pain, lessen hospitalization from sickle cell disease – UPI (free)

 

3 – Subacromial decompression versus diagnostic arthroscopy for shoulder impingement: randomised, placebo surgery controlled clinical trial – The BMJ (free)

Commentary: Most common shoulder operation is no more beneficial than placebo surgery – University of Helsinki, via EurekAlert (free)

Related research with similar results: Arthroscopic subacromial decompression for subacromial shoulder pain (free article, editorial and commentaries)

 

4 – Mortality due to cirrhosis and liver cancer in the United States, 1999-2016: observational study – The BMJ (free)

Commentaries: A Spike In Liver Disease Deaths Among Young Adults Fueled By Alcohol – NPR (free) AND Alcohol-related liver failure deaths rising among U.S. young adults – Reuters (free) AND More Americans Are Dying of Cirrhosis and Liver Cancer – The New York Times (10 articles per month are free)

 

5 – Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers – JAMA Oncology (free for a limited period)

Commentary: Association of complementary medicine, cancer treatment, survival – eCancer News (free)

 

6 – Clinical Evidence Synopsis: Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics – JAMA (free for a limited period)

Original Article: Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children – Cochrane Library (link to abstract – $ for full-text) AND Summary: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use (free)

Related Meta-Analysis: Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection (free) AND Probiotics for the Prevention of Clostridium difficile (link to abstract and commentaries)

 

7 – To continue taking or to stop taking antiplatelet drugs for a few days before non-cardiac surgery in adults – Cochrane Library (link to abstract – $ for full-text)

Summary: To continue taking or to stop taking antiplatelet drugs for a few days before non-cardiac surgery in adults – Cochrane Library (free)

We found low-certainty evidence that either continuation or discontinuation of antiplatelet therapy before non-cardiac surgery may make little or no difference to mortality, bleeding requiring surgical intervention, or ischaemic events”.

 

8 – Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study – Journal of the American Heart Association (free)

Commentaries: Poor air quality does not offset exercise’s heart benefits – AHA/ASA Newsroom (free) AND Why smog should not be your excuse to skip workouts – Reuters (free)

 

9 – Metformin and Risk of Hypertension in Taiwanese Patients With Type 2 Diabetes Mellitus – Journal of the American Heart Association (free)

“A reduced risk of hypertension is observed in metformin users in a dose‐response pattern”.

 

10 – Sulfonylureas as second line drugs in type 2 diabetes and the risk of cardiovascular and hypoglycaemic events: population based cohort study – The BMJ (free)

Editorial: Sulfonylureas as second line treatment for type 2 diabetes – The BMJ (free for a limited period)

Commentaries: Diabetes: Switching to Sulfonylureas from Metformin Linked to Increased Side Effects – MedicalResearch.com (free) AND Switching diabetes patients to sulfonylurea linked with complications – Pulse (free) AND Raised risk of MI and mortality when starting sulfonylurea – OnMedica (free)

 


 

1 – A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (free)

Editorial: Testing Epinephrine for Out-of-Hospital Cardiac Arrest (free)

Commentary: Using adrenaline in cardiac arrests results in less than 1 percent more people leaving hospital alive – University of Warwick, via EurekAlert (free)

See also: Infographic detailing result findings (free)

“A clinical trial of the use of adrenaline in cardiac arrests has found that its use results in less than 1% more people leaving hospital alive – but almost doubles the risk of severe brain damage for survivors of cardiac arrest”.

 

2 – Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease – Cochrane Library (link to abstract – $ for full-text)

Cochrane Summaries: New Cochrane health evidence challenges belief that omega 3 supplements reduce risk of heart disease, stroke or death (free) AND Omega-3 intake for cardiovascular disease (free)

Commentaries: Expert reaction to Cochrane review on omega-3 fatty acids and risk of heart disease, stroke and death – Science Media Centre (free) AND Omega 3 supplements don’t protect against heart disease – new review – The Conversation (free)

Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free article and commentary)

 

3 – Randomized Controlled Trial of E-Counseling for Hypertension: REACH – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Virtual counseling helps lower blood pressure – AHA News (free) AND E-counseling can lower blood pressure, heart disease risk – Medical News Today (free)

 

4 – Guideline: Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

5 – The association between nurse staffing and omissions in nursing care: A systematic review – Journal of Advanced Nursing (free)

Commentary: Nurse staffing levels linked to reports of missed care in adult wards – NIHR Signal (free)

 

6 – Global Burden of Atherosclerotic Cardiovascular Disease in People Living with the Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis – Circulation (free PDF)

Commentaries: HIV infection doubles risk of heart disease – University of Edinburgh, via ScienceDaily (free) AND Global Burden of HIV-Related CVD Has Tripled Over Two Decades – TCTMD (free)

 

7 – Report: Feeding in the first year of life – Scientific Advisory Committee on Nutrition (SACN) (free)

Commentaries: SACN publishes ‘Feeding in the first year of life’ report – Public Health England (free) AND Too many babies overfed, experts fear – BBC (free)

 

8 – Contrary to common belief, randomised controlled trials inevitably produce biased results – LSE Impact Blog (free)

Original Article: Why all randomised controlled trials produce biased results – Annals of Medicine (free)

Source: Nature Briefing Newsletter

 

9 – CBT for anxiety: new meta-analysis confirms significant improvements to target symptoms – The Mental Elf (free) (via @AllenFrancesMD)

Original article: Cognitive behavioral therapy for anxiety and related disorders: A meta-analysis of randomized placebo-controlled trials – Depression and Anxiety (free)

 

10 – Are electronic nicotine delivery systems helping cigarette smokers quit? Evidence from a prospective cohort study of U.S. adult smokers, 2015–2016 – PLOS One (free)

Commentaries: More Than 90 Percent Of Smokers Using E-cigarettes Still Smoking A Year Later – Georgia State University (free) AND Study casts doubt on effectiveness of e-cigs for smoking cessation – National Institutes of Health (free) AND Vaping May Not Help Smokers Kick the Habit – MedPage Today (free registration required)

 


 

1 – Association of Digital Media Use With Subsequent Symptoms of Attention-Deficit/Hyperactivity Disorder Among Adolescents – JAMA (link to abstract – $ for full-text)

Commentaries: More Screen Time For Teens Linked To ADHD Symptoms – NPR (free) AND Digital media use linked to behavioral problems in kids – University of Southern California, via ScienceDaily (free) AND Screen time linked to ADHD symptoms in teens – Reuters (free) AND ADHD study links teens’ symptoms with digital media use – CNN (free) AND Expert reaction to association of digital media use and ADHD symptoms among teenagers – Science Media Centre (free)

 

2 – Perspective: “Is There a Doctor on the Plane?” – JAMA (free for a limited period)

Interview: “Is There a Doctor on the Plane?” (free)

 

3 – Guideline for the treatment of chronic lymphocytic leukaemia: A British Society for Haematology Guideline (free)

 

4 – Report: Open Science by Design: Realizing a Vision for 21st Century Research (2018) – National Academies of Sciences, Engineering, and Medicine (free PDF)

News Release: Report Proposes Recommendations and New Framework to Speed Progress Toward Open Science (free)

 

5 – Clinical Trial Evidence Supporting FDA Approval of Drugs Granted Breakthrough Therapy Designation – JAMA (link to abstract – $ for full-text)

Commentaries: Are ‘breakthrough’ drugs as safe as other FDA-approved medicines? – CNN (free) AND Evidence to support ‘breakthrough’ drugs often very limited: study – Reuters (free)

 

6 – Head To Head: Does evidence based medicine adversely affect clinical judgment? – The BMJ (free) (via @michelaccad)

 

7 – Harms Reporting in Randomized Controlled Trials of Interventions Aimed at Modifying Microbiota: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Reporting on risks often inadequate for prebiotics, probiotics, synbiotics – ACP Internist (free) AND Probiotics studies often don’t disclose safety data or risks, report finds – STAT (free) AND Safety of Probiotic Supplements Is Not Guaranteed, Study Says – Consumer Reports (free)

“How to make an intervention safe? Don’t report the adverse events”. (via @EricTopol see Tweet)

 

8 – Review: Noninvasive ventilation in acute respiratory failure: which recipe for success? – European Respiratory Review (free)

Source: Critical Care Reviews Newsletter

 

9 – Auscultation for bowel sounds in patients with ileus: an outdated practice in the ICU? – Netherlands Journal of Critical Care (free PDF)

Editorial: It’s not a gut feeling: don’t listen to the bowels (free PDF)

Source: Critical Care Reviews Newsletter

 

10 – Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality – Gut (free)

Commentaries: FOB associated with rise in all-cause mortality – OnMedica (free) AND 3 key findings from Gut study on all-cause mortality associated with occult blood in stool – GI & Endoscopy (free) AND Fecal Occult Blood Flags Risks Beyond Colon Cancer – MedPage Today (free)

 


 

1 – Systematic Review: Nurses as substitutes for doctors in primary care – Cochrane Library (free)

Summary: Nurses as substitutes for doctors in primary care – Cochrane Library (free)

“This updated Cochrane Review indicates that nurses can effectively expand the capacity of the primary care workforce”.

 

2 – Comparison of Antibiotic Prescribing in Retail Clinics, Urgent Care Centers, Emergency Departments, and Traditional Ambulatory Care Settings in the United States – JAMA Internal Medicine (free for a limited period)

Commentaries: Overprescription in Urgent Care Clinics—The Fast and the Spurious – JAMA Internal Medicine (free for a limited period) AND Urgent care centers often prescribe unnecessary antibiotics – Reuters (free) AND Study spotlights inappropriate prescribing in urgent care – CIDRAP (free)

 

3 – Clinical Review: Novel therapies for diabetes mellitus in pregnancy – The BMJ (free for a limited period)

 

4 – 9 in 10 infants worldwide received vaccinations in 2017 – World Health Organization (free)

 

5 – Integrating Responses at the Intersection of Opioid Use Disorder and Infectious Disease Epidemics: Proceedings of a Workshop – National Academies of Sciences, Engineering and Medicine (free)

Commentaries: National Academies target opioid abuse and infectious disease consequences – Emory Health Sciences (free) AND Within opioid abuse epidemic, infectious disease epidemic emerges – Reuters (free)

 

6 – Richard Lehman’s journal review, 16 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

7 – Is your cellphone giving you cancer? A comprehensive guide to the messy, frustrating research – VOX (free)

 

8 – Risks of ovarian, breast, and corpus uteri cancer in women treated with assisted reproductive technology in Great Britain, 1991-2010: data linkage study including 2.2 million person years of observation – The BMJ (free)

Commentaries: No association found between fertility treatment, some types of cancer – ACP Internist (free) AND Fertility treatment does not appear to raise serious cancer risk – OnMedica (free)

 

9 – Smartphone-based screening for visual impairment in Kenyan school children: a cluster randomised controlled trial – The Lancet Global Health (free)

Commentaries: Strengthening eye health evidence for children in low-income and middle-income countries (free) AND App screening boosts children’s eye health – Medical Health News (free)

 

10 – International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging (free)

Related: Polypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) AND The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF) AND Common ED Medication Errors: Polypharmacy – emDocs (free) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free) AND The other big drug problem: Older people taking too many pills – The Whashington Post (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) 

 


 

1 – Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials – The Lancet (free)

Commentaries: Weight-adjusted aspirin for cardiovascular prevention – The Lancet (free) AND One dose of aspirin doesn’t fit all – University of Oxford (free)

Practice Changing Article. “Low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and had no benefit in the 80% of men and nearly 50% of all women weighing 70 kg or more. By contrast, higher doses of aspirin were only effective in patients weighing 70 kg or more.”

 

2 – Vulnerability to snakebite envenoming: a global mapping of hotspots – The Lancet (free)

Commentaries: Addressing the global challenge of snake envenoming – The Lancet (free) AND New study maps the areas where people are most vulnerable to death following snakebite – London School of Tropical Medicine (free) AND New study finds 93 million people vulnerable to death from snakebites – Institute for Health Metrics and Evaluation (free)

 

3 – Association of Inferior Vena Cava Filter Placement for Venous Thromboembolic Disease and a Contraindication to Anticoagulation With 30-Day Mortality – JAMA Network Open (free)

Commentaries: Inferior Vena Cava Filters and Mortality: Is It the Underlying Process, the Patient, or the Device? (free)

“Could IVC filters be causing harm? They began being used before @US_FDA started approving devices. This article raises possibility of increased mortality. Maybe where we need trials to determine safety and effectiveness”. (via @hmkyale see Tweet)

 

4 – 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis – Annals of Rheumatic Disease (free)

 

5 – 2018 Guidelines of the Taiwan Society of Cardiology, Taiwan Society of Emergency Medicine and Taiwan Society of Cardiovascular Interventions for the management of non ST-segment elevation acute coronary syndrome – Journal of the Formosan Medical Association (free)

Related Guidelines: 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (free) AND 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes (free)

 

6 – CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) in 2018 – Japanese Association of Cardiovascular Intervention and Therapeutics (free)

 

7 – Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility – Toxicological Sciences (free)

Commentaries: New digital chemical screening tool could help eliminate animal testing – Science (free) AND Database Analysis More Reliable Than Animal Testing For Toxic Chemicals – Johns Hopkins Bloomberg School of Public Health (free) AND Software beats animal tests at predicting toxicity of chemicals – Nature News (free)

 

8 – Review: Cardiac rehabilitation: A class 1 recommendation – Cleveland Clinic Journal of Medicine (free)

Related Guidelines: Cardiac rehabilitation – Scottish Intercollegiate Guidelines Network (free) AND Myocardial infarction: cardiac rehabilitation and prevention of further cardiovascular disease – National Institute for Health and Care Excellence (free)

 

9 – Hypertension Among Youths — United States, 2001–2016 – Centers for Disease Control and Prevention (free)

Commentaries: 800,000 More Adolescents Classified as Hypertensive Under New Guidelines – NEJM Physician’s First Watch (free) AND New guidelines label 795K more US children as hypertensive – Cardiovascular Business (free)

 

10 – Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study – American Journal of Clinical Nutrition (free for a limited period)

Commentaries: Study finds no significant link between whole dairy products and heart disease, stroke – News Medical (free) AND Full-fat dairy may actually benefit heart health – Medical News Today (free)

Related Studies: Meta-Analysis: Cheese consumption and risk of cardiovascular disease (link to abstract and commentaries) AND Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality (free study and commentaries)

 


 

1 – INSPIRE: Seven strategies for ending violence against children – World Health Organization (free resources)

Fact Sheet: Violence against children – World Health Organization (free)

The package includes the core document describing what the INSPIRE strategies and interventions are; an implementation handbook that provides details on how to implement the interventions, and a set of indicators to measure the uptake of INSPIRE and its impact on levels of violence against children.

 

2 – Comparison of the Safety Planning Intervention With Follow-up vs Usual Care of Suicidal Patients Treated in the Emergency Department – JAMA Psychiatry (free for a limited period)

Author Interview: Association of Safety Planning Intervention With Subsequent Suicidal Behavior Among ER-Treated Suicidal Patients (free)

Commentaries: ED Intervention with Follow-Up Appears to Reduce Suicidal Behaviors – NEJM Physician’s First Watch (free) AND A Simple Emergency Room Intervention Can Help Cut Suicide Risk – NPR (free)

Related Studies: Suicide Prevention in an Emergency Department Population (free study and commentaries) AND Strategies to prevent death by suicide (link to abstract and commentaries)

 

3 – Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Bleeding Risk Increased With NSAID Use in Anticoagulated A-fib Patients: RE-LY Analysis – TCTMD (free) AND NSAID, anticoagulant combo ups risk for bleeding events in AFib patients – Cardiovascular Business (free) Concomitant NSAIDs and Anticoagulants in Atrial Fibrillation – American College of Cardiology (free)

 

4 – Infographic: Testing for non-alcoholic fatty liver disease -The BMJ (free PDF)

 

5 – The right diet can boost potency of cancer drugs – Nature News (free)

Original article: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors – Nature (link to abstract – $ for full-text)

Related: Top oncologist to study effect of diet on cancer drugs – The Guardian (free)

“Diets appear to matter in mouse cancer Rx – can these preclinical findings be translated to humans?” (via @Aiims1742 see Tweet)

 

6 – Report: Research into physiotherapy for musculoskeletal conditions – NIHR Dissemination Centre (free PDF)

This new NIHR report brings together key research relevant to those delivering musculoskeletal physiotherapy services.

 

7 – Last Month in Oncology with Dr. Bishal Gyawali: June 2018 – eCancer News (free)

This review has an interesting opinion on changing definitions of clinically meaningful endpoints in cancer research.

 

8 – Research Methods & Reporting: Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians – The BMJ (free)

 

9 – Anticoagulation for perioperative thromboprophylaxis in people with cancer – Cochrane Library (free)

Summary: Blood thinners for the prevention of blood clots in people with cancer undergoing surgery – Cochrane Library (free)

 

10 – Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Stopping the Alteplase Indication Creep – Emergency Medicine Literature of Note (free) AND Alteplase unlikely to reduce disability after mild stroke without disabling deficits – 2 Minute Medicine (free) AND Lytic No Better Than Aspirin for Mild Ischemic Stroke – MedPage Today (free registration required)

 


 

1 – Guideline: Rheumatoid arthritis in adults: management – National Institute for Health and Care Excellence (free)

 

2 – Guideline: Brain tumours (primary) and brain metastases in adults – National Institute for Health and Care Excellence (free)

 

3 – Impact of 2017 ACC/AHA guidelines on prevalence of hypertension and eligibility for antihypertensive treatment in United States and China: nationally representative cross sectional study – The BMJ (free)

Commentary: Expert reaction to study looking at American blood pressure guidelines and how many people in the USA and China would be classed as having high blood pressure – Science Media Centre (free)

 

4 – Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy (link to abstract – $ for full-text)

Commentary: Is Short-Course Antibiotic Treatment for CAP Effective? – MPR (free)

 

5 – News Release: Trial wipes out more than 80 per cent of disease-spreading mozzie – Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Government (free)

Commentary: Australian experiment wipes out over 80% of disease-carrying mosquitoes – CNN (free)

 

6 – Perspective: Fractional-Dose Yellow Fever Vaccination — Advancing the Evidence Base – New England Journal of Medicine (free)

Related Research: Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Preliminary Report – The New England Journal of Medicine (free)

 

7 – Cumulative Incidence of Hypertension by 55 Years of Age in Blacks and Whites: The CARDIA Study – Journal of the American Heart Association (free)

Commentaries: Most black adults have high blood pressure before age 55 – AHA / ASA Newsroom (free) AND New CARDIA Data: 75% of African-Americans Have Hypertension by Age 55 – TCTMD (free)

 

8 – News Release: FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions – U.S. Food and Drug Administration (free)

Commentaries: FDA Strengthens Warnings for Fluoroquinolone Antibiotics – MPR (free) AND FDA Announces Labeling Changes for Fluoroquinolones Due to Mental Health AEs, Blood Sugar Disturbances – MD Magazine (free)

 

9 – Effect of cannabis use in people with chronic non-cancer pain prescribed opioids: findings from a 4-year prospective cohort study – The Lancet Public Health (free)

Commentaries: A painful lesson: are we repeating previous mistakes in pain management? – The Lancet Public Health (free) AND Use of illicit cannabis does not reduce chronic pain, according to new Australian study – RACGP (free)

Related: Efficacy and adverse effects of medical marijuana for chronic noncancer pain: Systematic review of randomized controlled trials – Canadian Family Physician (free) AND Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review – VA Evidence-based Synthesis Program (free) AND Cannabis products for adults with chronic neuropathic pain – Cochrane Library (free)

 

10 – Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Smoking Marijuana May Be Tied to Cough, Sputum Production – HealthDay (free) AND Regular marijuana use is associated with development of respiratory issues – 2 Minute Medicine (free)

 


 

1 – Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorial: USPSTF Recommendations for Assessment of Cardiovascular Risk With Nontraditional Risk Factors: Finding the Right Tests for the Right Patients (free)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) level, or coronary artery calcium (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.

 

2 – Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)

Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)

Commentaries: Study: Multivitamins Do Not Prevent Strokes, Heart Attacks or Cardiovascular Disease Deaths – University of Alabama at Birmingham, via NewsWise (free) AND Multivitamin-mineral supplements do not reduce heart disease, deaths – Reuters (free)

Related: Supplements Not Effective for CVD Prevention and Treatment (link to abstract and commentaries) AND Multivitamins are probably a waste of money (free commentaries)

 

3 – Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Newer, older insulin formulations may offer similar glucose-lowering effects – ACP Internist (free) AND HbA1c Reduction Similar in Old, New Basal Insulin Analogues – MedPage Today (free registration required)

 

4 – Association of Early Introduction of Solids With Infant Sleep: A Secondary Analysis of a Randomized Clinical Trial – JAMA Pediatrics (free)

Author Interview: Effects of Early Solid Food Introduction on Infant Sleep (free audio)

Commentaries: Babies fed solids earlier ‘sleep better’ – NHS Choices (free) AND Feeding your baby solids early may help them sleep, study suggests – The Guardian (free) AND Giving your baby solid food early won’t help them sleep better – The Conversation (free)

 

5 – Effect of a Home-Based Wearable Continuous ECG Monitoring Patch on Detection of Undiagnosed Atrial Fibrillation: The mSToPS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Video: Effect of a Home-Based Wearable ECG Patch Monitor on Detection of Undiagnosed Atrial Fibrillation in Individuals at Increased Risk of Atrial Fibrillation (free)

Commentary: If You Look For Atrial Fibrillation You Will Find Atrial Fibrillation – Cardiobrief (free)

Related: Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? (free commentaries)

 

6 – Review: Update on infection control practices in cancer hospitals – CA: A Cancer Journal of Clinicians (free)

 

7 – Review:  Optimal pain management for patients with cancer in the modern era – CA: A Cancer Journal of Clinicians (free)

 

8 – Periconception glycaemic control in women with type 1 diabetes and risk of major birth defects: population based cohort study in Sweden – The BMJ (free)

Commentary: Higher risk of heart defects in babies of mothers with type 1 diabetes – Karolinska Institutet, via EurekAlert (free)

 

9 – Public health implications of overscreening for carotid artery stenosis, prediabetes, and thyroid cancer – Public Health Reviews (free)

 

10 – Consensus Report: Returning Individual Research Results to Participants: Guidance for a New Research Paradigm (2018) – National Academies of Sciences, Engineering, and Medicine (free PDF)

Commentaries: National Academies panel urges researchers to routinely share test results with study participants – STAT (free) AND If you give your DNA and tissues to science, should you get a peek at what they might contain? – Science (free) AND New report says individual research results should be shared with participants more often – National Academies of Sciences, Engineering, and Medicine (free)

Related Viewpoint: Return of Research Results to Study Participants: Uncharted and Untested – JAMA (free for a limited period)

 


 

1 – Summary of the international clinical guidelines for the management of hospital-acquired and ventilator-acquired pneumonia – ERJ Open Research (free)

Editorial: Treating nosocomial pneumonia: what’s new (free)

Related Guidelines: International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) AND Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society (free)

Source: Critical Care Reviews Newsletter

 

2 – Guideline: Recommendations on screening for asymptomatic bacteriuria in pregnancy – Canadian Task Force on Preventive Health Care (free)

See also: Summary of recommendations for clinicians and policy-makers / other resources from CTFPHC (all free)

 

3 – Draft Statement: Antibiotics should be restricted for COPD – National Institute for Health and Care Excellence (free)

Commentaries: Antibiotics should be restricted for COPD, says NICE – OnMedica (free) AND UK officials recommend limits on antibiotics for COPD – CIDRAP (free)

The draft antimicrobial guidance recommends that antibiotics should be offered to people who have a severe flare up of symptoms, also known as a severe acute exacerbation”

 

4 – Oposition to Breast-Feeding Resolution by U.S. Stuns World Health Officials – The New York Times (10 articles per month are free)

 

5 – Richard Lehman’s journal review, 9 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals

 

6 – Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Cabozantinib in Hepatocellular Carcinoma – NEJM Resident 360 (free)

Median overall survival was 10.2 months with cabozantinib and 8.0 months with placebo, but the rate of high-grade adverse events in the cabozantinib group was approximately twice that observed in the placebo group. (more on this study in Richard Leeman’s review above)

 

7 – Percutaneous coronary intervention for stable angina in ORBITA – Authors’ reply – The Lancet (free) – The Lancet (free)

Original study: Percutaneous coronary intervention in stable angina (ORBITA) (link to abstract and commentaries)

Related commentaries: Viewpoint: Placebo Effect of the Heart (free) AND Sham Surgeries: A Tale of Medical Reversals & the Role of the Media (free)

Related research: Research: Physiology-Stratified Analysis of ORBITA (free research and commentaries)

 

8 – Richard Smith: Reducing global road traffic crashes and injuries – The BMJ Opinion (free)

Related reports: The High Toll of Traffic Injuries : Unacceptable and Preventable – The World Bank (free PDF) AND Save LIVES: a road safety technical package (free) AND Unfinished Journey: The Global Health Response to Children & Road Traffic – FIA Foundation (free PDF) AND Securing safe roads: the politics of change – World Resources Institute Ross Center for Sustainable Cities (free news release and PDF)

 

9 – Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)

Summary: Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)

Related Research: Randomized Trial: Negative Pressure Wound Therapy No Better Than Regular Dressing in Severe Open Fracture of the Lower Limb (link to abstract and commentaries)

 

10 – Physician Burnout, Well-being, and Work Unit Safety Grades in Relationship to Reported Medical Errors – Mayo Clinic Proceedings (link to abstract – $ for full-text)

Commentaries: Medical errors may stem more from physician burnout than unsafe health care settings – Stanford Medicine, via ScienceDaily (free) AND Physician burnout, depression can lead to major medical errors: Study – ABC News (free) AND Burnout Tied to Twofold Higher Risk for Medical Errors – Medscape (free registration required)

Related: Perspective: The Burnout Crisis in American Medicine (free commentaries on the subject)

 


 

1 – Guidelines On The Management Of Acute Respiratory Distress Syndrome – Intensive Care Society (free PDF) (via @CritCareReviews)

Related Guidelines: The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free) AND An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome (free)

 

2 – WHO Manual: Preventing disease through a healthier and safer workplace – World Health Organization (free PDF)

Source: International Health Policies Newsletter

 

3 – Clinical Update: Long-acting Reversible Contraception—Highly Efficacious, Safe, and Underutilized – JAMA (free for a limited period)

Clinical Review Audio: Return of the IUD: Long-acting Reversible Contraception Is Safe and Effective (free)

 

4 – Seriously, Juice Is Not Healthy – The New York Times (10 articles per month are free)

“Would you take a multivitamin if it contained 10 teaspoons of sugar? No. Then why are you drinking juice?” (via @NYTHealth see Tweet)

 

5 – Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: For Women Over 30, There May Be A Better Choice Than The Pap Smear – NPR (free) AND Study Suggests HPV Test More Accurate Than Pap Smear for Cervical Cancer Screening – AJMC (free) AND HPV testing could be more accurate than smear tests for initial screening of cervical cancer – NHS Choices (free)

 

6 – The health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes – Environmental Research (free) (via @Mental_Elf and @AllenFrancesMD)

Commentary: It’s official — spending time outside is good for you – University of East Anglia, via ScienceDaily (free)

 

7 – A Systematic Review of the Effects of Hyperoxia in Acutely Ill Patients: Should We Aim for Less? – BioMed Research International (free)

Related Meta-Analysis:  Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)

Source: Critical Care Reviews Newsletter

 

8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Related: Ebola virus outbreak likely over in Congo, WHO says – NBC News (free) AND Good news: the Ebola outbreak in DRC is contained – VOX (free)

 

9 – Use of ‘smart drugs’ on the rise – Nature (free)

Related: A ‘smart’ approach to performance drugs – ACP Internist (free) AND Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)

 

10 – Association of Prenatal Exposure to Population-Wide Folic Acid Fortification With Altered Cerebral Cortex Maturation in Youths – JAMA Psychiatry (free)

Commentaries: Folic acid linked to healthy brain development through childhood – Reuters (free) AND Folic Acid Fortification May Have Role in Sustaining Mental Health – AJMC (free) AND Prenatal Exposure to Folic Acid Appears to Promote Healthy Brain Development – Psychiatric News Alert (free) AND Perinatal Folic Acid May Protect Against Serious Mental Illness in Young People – MedicalResearch.com (free)

 


 

1 – Report: Delivering quality health services: A global imperative for universal health coverage – World Health Organization (free)

News Release: Low quality healthcare is increasing the burden of illness and health costs globally (free)

Commentary: Universal quality healthcare coverage—a commitment to building a healthier and more productive society – The BMJ Opinion (free)

Related: Handbook for national quality policy and strategy: A practical approach for developing policy and strategy to improve quality of care – World Health Organization (free)

 

2 – Hypothalamic–Pituitary and Growth Disorders in Survivors of Childhood Cancer: An Endocrine Society Clinical Practice Guideline – The Journal of Clinical Endocrinology & Metabolism (free PDF)

Commentaries: Up to half of childhood cancer survivors will develop hormone disorders – The Endocrine Society, via ScienceDaily (free) AND Guideline Addresses Endocrine Effects After Childhood Cancer – Medscape (free registration required)

 

3 – Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Screening for Breast Cancer: A Life-Table Model – JAMA Oncology (free)

Editorial: Implementation Challenges for Risk-Stratified Screening in the Era of Precision Medicine (free)

Author Interview: Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Breast Cancer Screening (free)

Commentaries: New approach to breast cancer screening — tailoring guidelines for each patient — may save lives and money, study says – STAT (free) AND No screening is better for women with low breast cancer risk, finds study – Guardian (free) AND Breast Cancer Screening Only for Women at Higher Risk – Medscape (free registration required)

 

4 – Review: Heart failure with preserved ejection fraction: from mechanisms to therapies – European Heart Journal (free)

 

5 – Review: Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies – Circulation (free)

 

6 – Hidden conflicts? – Science Magazine (free)

““Pay-later conflicts of interest” have gone largely unnoticed & entirely unpoliced”. (via @cpiller see Tweet)

 

7 – Clinical practice guidelines for the management of non-specific low back pain in primary care: an updated overview – European Spine Journal (free)

 

8 – Risks and benefits of direct oral anticoagulants versus warfarin in a real world setting: cohort study in primary care – The BMJ (free)

Commentary: Analysis Finds Less Bleeding — But Potentially Greater Mortality Risk — with Some Newer Anticoagulants – NEJM Physician’s First Watch (free)

 

9 – Species-specific activity of antibacterial drug combinations – Nature (link to abstract – $ for full-text)

Commentaries: Study: For antibiotics, good things may come in pairs – CIDRAP (free) AND Combining antibiotics alters effectiveness, study says – UPI (free) AND As drug resistance grows, combining antibiotics could turn up new treatments – STAT (free)

 

10 – Continuous low-dose antibiotic prophylaxis for adults with repeated urinary tract infections (AnTIC): a randomised, open-label trial – The Lancet Infectious Diseases (free)

Invited Commentary: Preventing urinary tract infections in patients with neurogenic bladder (free)

 


 

1 – Guideline for Antibiotic Use in Adults with Community-acquired Pneumonia – The Korean Society of Infectious Disease (free)

Related Guideline: Pneumonia: Diagnosis and Management of Community- and Hospital-Acquired Pneumonia in Adults – National Institute for Health and Care Excellence (free)

 

2 – An evidence-based approach to evaluation and management of the febrile child in Indian emergency department – International Journal of Critical Illness & Injury Science (free)

 

3 – Pathophysiology, diagnosis and management of MINOCA: an update – European Heart Journal: Acute Cardiovascular Care (free)

 

4 – Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study – Journal of the American Heart Association (free)

Editorial: Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): It’s Time to Face Reality! (free)

 

5 – Treatment of Angina: Where Are We? – Cardiology (free)

Source: Critical Care Reviews Newsletter

 

6 – Adverse effect of long work hours on incident diabetes in 7065 Ontario workers followed for 12 years – BMJ Open Diabetes Research & Care (free)

Commentaries: Clocking up 45+ working hours/week linked to heightened risk of diabetes in women – BMJ, via ScienceDaily (free) AND Greater Risk of Diabetes in Women With Longer Work Week – MedicalResearch.com (free)

Related Study: Effect of Work Stressors on the Risk of Type 2 Diabetes (link to abstract and commentary)

 

7 – Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates – Nature Medicine (link to abstract – $ for full-text)

Commentaries: Pregnancy loss occurs in 26 percent of Zika-infected monkeys – NIH News Releases (free) AND Monkey studies suggest Zika role in miscarriage may be higher than thought – CIDRAP (free)

 

8 – Alarming polio outbreak spreads in Congo, threatening global eradication efforts – Science (free)

 

9 – Carbohydrate Replacement of Rice or Potato with Lentils Reduces the Postprandial Glycemic Response in Healthy Adults in an Acute, Randomized, Crossover Trial – The Journal of Nutrition (link to abstract – $ for full-text)

Commentaries: Lentils significantly reduce blood glucose levels – University of Guelph, via ScienceDaily (free) AND Replace Carbs With Lentils to Blunt Glucose Spike After Meals – Medscape (free registration required)

 

10 – Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease Risk Factor Development: An Observational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Hypertensive disorders during pregnancy associated with increased rates of later CVD – ACP Internist (free) AND High blood pressure in pregnancy tied to heart disease risk afterward – Reuters (free) AND Women who experience hypertensive disorders during pregnancy are at high risk for developing high blood pressure, diabetes, and high cholesterol later in life – 2 Minute Medicine (free)

Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries) AND Gestational Hypertension and Future Risk of Cardiovascular Disease (free research and editorial)

 


 

1 – Anticonvulsants in the treatment of low back pain and lumbar radicular pain: a systematic review and meta-analysis – Canadian Medical Association Journal (free)

Commentaries: Class of drugs used as alternative to opioids for back pain are ineffective, have potentially serious side effects: report – The Globe and Mail (free) AND Anticonvulsant drugs ineffective for low back pain and can cause harm, despite increased prescribing – CMAJ, via EurekAlert (free)

Related Meta-Analysis: Benefits and safety of gabapentinoids in chronic low back pain (free research and commentaries)

 

2 – The Carbohydrate-Insulin Model of Obesity: Beyond “Calories In, Calories Out” – JAMA Internal Medicine (free for a limited period)

 

3 – Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Epinephrine vs. Norepinephrine for Cardiogenic Shock – American College of Cardiology (free) AND Norepinephrine Bests Epinephrine in Battle of the Vasopressors in Cardiogenic Shock – TCTMD (free)

 

4 – Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Related Perspective: Metastasis-free Survival — A New End Point in Prostate Cancer Trials – New England Journal of Medicine (free)

Commentaries: Enzalutamide: Now Also for Earlier Use in Prostate Cancer? – Medscape (free registration required) AND Enzalutamide Improves Outcomes for Aggressive Prostate Cancer – MPR (free) AND Enzalutamide Postpones Metastasis for a Subset of High-Risk Patients With Prostate Cancer – Cancer Therapy Advisor (free)

 

5 – Editorial: Immunotherapy: hype and hope – The Lancet Oncology (free) (via @OphiraG)

Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)

 

6 – Fertility Preservation for Patients with Malignant Disease. Guideline of the DGGG, DGU and DGRM – Recommendations and Statements for Girls and Women – Geburtshilfe Frauenheilkd (free)

Related guidelines: Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free) AND Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines – Clinical and Experimental Reproductive Medicine (free) AND Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline – Human Fertility (free)

 

7 – Influenza vaccine for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

Summary: Influenza vaccine for people with chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

 

8 – Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies – The Lancet (link to abstract – $ for full-text)

Commentaries: Increased risk of birth defects in babies after first-trimester exposure to lithium – Mount Sinai School of Medicine, via ScienceDaily (free) AND Lithium in Pregnancy Tied to Infant Morbidity, Malformation Risk – Medscape (free)

 

9 – Metformin exposure in first trimester of pregnancy and risk of all or specific congenital anomalies: exploratory case-control study – The BMJ (free)

In this large international, population-based database, no evidence was found of an overall increased risk of congenital anomalies after first trimester metformin exposure.

 

10 – Australia wins landmark WTO ruling on plain tobacco packaging – Reuters (free)

Other commentaries: WTO Tobacco Ruling Opens Door to New Plain-Packaging Laws – Bloomberg (free) AND ‘Resounding victory’: Australia wins tobacco plain packaging dispute – The Guardian (free) AND Australian Tobacco Plain Packaging Upheld In Decision At WTO – Intellectual Property Watch (free)

Source: International Health Policies Newsletter

 


 

1 – A Multicenter Study of Patient-Reported Infectious and Noninfectious Complications Associated With Indwelling Urethral Catheters – JAMA Internal Medicine (free)

Commentary: Foleys Aren’t Fun: Patient Study Shows Catheter Risks – University of Michigan, via NewsWise (free)

“More than half of patients surveyed while they had a urinary catheter, and again weeks later, reported a complication – and infections were only part of the problem” (from NewsWise)

 

2 – Out-of-hours discharge from intensive care, in-hospital mortality and intensive care readmission rates: a systematic review and meta-analysis – Intensive Care Medicine (free)

Source: Critical Care Reviews Newsletter

“Out-of-hours discharge from an ICU is strongly associated with both in-hospital death and ICU readmission. Whether these increases in mortality and readmission result from patient differences, differences in care, or a combination remains unclear”.

 

3 – Review: Chronic hyperkalemia in non-dialysis CKD: controversial issues in nephrology practice – Journal of Nephrology (free)

 

4 – Opinion: Endless Gaming May Be a Bad Habit. That Doesn’t Make It a Mental Illness – The New York Times (10 articles per month are free)

Related: Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free)

“The World Health Organization has made “internet gaming” a diagnosable disorder. But many experts aren’t even sure it exists”.

 

5 – Richard Lehman’s journal review, 2 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

6 – Outbreak of Ebola virus disease in the Democratic Republic of the Congo, April–May, 2018: an epidemiological study – The Lancet (free)

Invited Commentary: Ebola virus disease: 11 323 deaths later, how far have we come? (free)

Related: Ebola Outbreak in Congo ‘Largely Contained’, says WHO (free statement and commentary)

 

7 – Management of multimorbidity using a patient-centred care model: a pragmatic cluster-randomised trial of the 3D approach – The Lancet (free)

Commentaries: Patient-centred care for multimorbidity: an end in itself? – The Lancet (free) AND Results of the largest ever multimorbidity trial in primary care challenge current thinking -NIHR News (free)

Related: Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers (series of free articles on the topic) AND Multimorbidity: A Priority for Global Health Research (free report and commentaries)

“In the largest ever trial of an intervention to treat people with multiple long-term conditions (multimorbidity) in primary care, NIHR-researchers found that the patient-centred approach taken improved patients’ experience of their care but did not improve their health-related quality of life. This is a challenge to current thinking on which UK and international guidelines are based”. (from NIHR News)

 

8 – Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Expert reaction to research association between coffee and lower risk of death – Science Media Centre (free) AND Fresh grounds for coffee: Study shows it may boost longevity – Associated Press (free) AND Coffee Drinkers Are More Likely To Live Longer. Decaf May Do The Trick, Too – NPR (free)

Related Studies: Meta-Analysis: Coffee consumption and health (free research and commentaries) AND Coffee Drinking and Mortality Studies (link to abstract and commentaries)

Another observational study showing possible benefits from drinking coffee.

 

9 – Endocrine Late Effects in Survivors of Cancer in Adolescence and Young Adulthood: A Danish Population-Based Cohort Study – JAMA Network Open (free)

Invited Commentary: Unmet Survivorship Care Needs of Adolescent and Young Adult Cancer Survivors (free)

Related Reviews: Endocrine late-effects of childhood cancer and its treatments – European Journal of Endocrinology (free) AND Metabolic syndrome induced by anticancer treatment in childhood cancer survivors – Annals of Pediatric Endocrinology & Metabolism (free) AND Screening and management of adverse endocrine outcomes in adult survivors of childhood and adolescent cancer – The Lancet Diabetes & Endocrinology (free)

 

10 – Cardiovascular Toxicity in Cancer Survivors: Current Guidelines and Future Directions – American College of Cardiology (free)

Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)

 


 

1 – Continuity of care with doctors—a matter of life and death? A systematic review of continuity of care and mortality – BMJ Open (free)

Commentaries: Seeing same doctor every time ‘reduces risk of death’ – NHS Choices (free) AND Sticking with 1 doctor could have health benefits: Study – UPI (free)

 

2 – Opinion: Why do-it-yourself blood tests are a bad idea – Common Sense Family Doctor (free)

Related: Benjamin Mazer: Theranos’ dystopian vision lives on – The BMJ Opinion (free)

“Routine blood testing in healthy people has numerous downsides that Holmes never mentioned, including poor predictive value, false positives, and overdiagnosis” (from Common Sense Family Doctor)

“When you go about testing everyone for everything, you don’t create a world of healthy people….you create a nightmare where everyone is sick” (from The BMJ Opinion)

 

3 – Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free)

Related: Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

“Great new study about science outreach via Twitter: Initially, scientists mostly tweet to each other. But after accumulating about 1000 followers, scientists reach an increasing number of journalists, policy makers, and other members of the public”. (via @JSheltzer see Tweet)

 

4 – Four principles to make evidence synthesis more useful for policy – Nature (free)

Related: A fresh approach to evidence synthesis – Nature (free)

“Reward the creation of analyses for policymakers that are inclusive, rigorous, transparent and accessible, urge Christl A. Donnelly and colleagues”.

 

5 – American College of Gastroenterology Monograph on Management of Irritable Bowel Syndrome – American Journal of Gastroenterology (free for a limited period)

Related guidelines: Irritable bowel syndrome in adults: diagnosis and management – National Institute for Health and Care Excellence (free) AND Clinical Practice Guidelines for Irritable Bowel Syndrome in Korea, 2017 Revised Edition – Journal of Neurogastroenterology and Motility (free) AND Evidence-based clinical practice guidelines for irritable bowel syndrome – Journal of Gastroenterology (free)

Source: NewsWise

 

6 – Update of Recommendations for Use of Once-Weekly Isoniazid-Rifapentine Regimen to Treat Latent Mycobacterium tuberculosis Infection – Centers for Disease Control and Prevention (free)

Commentary: CDC Updates Guidelines on Weekly Therapy for Latent TB Infection – Physician’s First Watch (free)

Related WHO Guideline: Latent TB Infection (free guideline and news release)

 

7 – The plateau of human mortality: Demography of longevity pioneers – Science (link to abstract – $ for full-text)

Commentaries: There’s no limit to longevity, says study that revives human lifespan debate – Nature News (free) AND Italian study suggests human lifespan could continue increasing – NHS Choices (free) AND Age 105? Then you’ve a better chance of living even longer – The Guardian (free) AND How Long Can We Live? The Limit Hasn’t Been Reached, Study Finds – The New York Times (free)

 

8 – Editorial: HPV vaccination: balancing facts – Cochrane Library (free)

Related Cochrane Review: Prophylactic Vaccination Against HPV to Prevent Cervical Cancer (link to review and commentaries)

 

9 – Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

Summary: Beta-blockers and inhibitors of the renin-angiotensin aldosterone system for chronic heart failure with preserved ejection fraction – Cochrane Library (free)

Related Meta-Analysis: Drug treatment effects on outcomes in heart failure with preserved ejection fraction: a systematic review and meta-analysis – Heart (free)

This Cochrane review suggests mineralocorticoid receptor antagonists may be of benefit to reduce hospitalizations, while the meta-analysis in Heart suggests beta-blockers may improve all-cause and cardiovascular mortality…

 

10 – The 2016 global and national burden of diabetes mellitus attributable to PM2·5 air pollution – The Lancet Planetary Health (free)

Commentaries: Air pollution and diabetes: it’s time to get active! – The Lancet Planetary Health (free) AND Air pollution linked to 3.2 million new diabetes cases in one year – CNN (free) AND Air pollution contributes significantly to diabetes globally – Washington University School of Medicine (free)

Related: WHO Report: 9 out of 10 People Worldwide Breathe Polluted Air (free report and commentaries) AND Ambient Air Pollution in Relation to Diabetes (free research) AND The Lancet Commission on pollution and health (free resources) AND Air Pollution and Mortality (free research and commentaries) AND Global burden of disease attributable to ambient air pollution (free report and commentaries) AND 5.5 million lives were lost in 2013 to diseases associated with Air Pollution (free report and infographic)

 


 

1 – A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiology – Clinical Infectious Diseases (free)

News Release: IDSA/ASM Lab Diagnosis Guide Helps Health Care Providers Navigate Rapidly Changing Landscape of Infectious Diseases Tests, Enabling Faster, Better Treatment – Infectious Diseases Society of America (free)

 

2 – Prospective external validation of the Predicting Out-of-OFfice Blood Pressure (PROOF-BP) strategy for triaging ambulatory monitoring in the diagnosis and management of hypertension: observational cohort study – The BMJ (free)

Commentary: Reducing the need for 24-hour blood pressure monitors in general practice – University of Oxford (free)

The tool: freely available online here 

 

3 – Risk of meticillin resistant Staphylococcus aureus and Clostridium difficile in patients with a documented penicillin allergy: population based matched cohort study – The BMJ (free)

Commentaries: Penicillin-allergic patients may run bigger risk of MRSA, C diff – CIDRAP (free) AND Patients believed allergic to penicillin have increased risks of MRSA and C. difficile – Massachusetts General Hospital (free) AND Patients with Documented Penicillin Allergy at Higher Risk for MRSA, C. difficile – NEJM Physician’s First Watch (free)

 

4 – Perspective: Potential Policy Approaches to Address Diet-Related Diseases – JAMA (free for a limited period)

Related: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND To improve global health, tax the things that are killing us – Financial Times (free articles, commentaries and reports) AND The Lancet taskforce on NCDs and economics (free series and commentaries)

 

5 – Perspective: What’s the Best Way to Treat Normal-Weight People With Metabolic Abnormalities? – JAMA (free for a limited period)

 

6 – Guidelines for the management of osteoporosis and fragility fractures – Internal and Emergency Medicine (free)

Related Guidelines: UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free) AND Treatment of Low Bone Density or Osteoporosis to Prevent Fractures in Men and Women: A Clinical Practice Guideline Update from the American College of Physicians – Annals of Internal Medicine (free)

 

7 – Chinese Society of Allergy Guidelines for Diagnosis and Treatment of Allergic Rhinitis – Allergy Asthma & Immunology Research (free)

 

8 – Midlife contributors to socioeconomic differences in frailty during later life: a prospective cohort study – The Lancet Public Health (free)

Commentaries: Frailty: from clinical syndrome to epidemiological construct? – The Lancet Public Health (free) AND Old before your time? Scientists have put together five warning signs middle-aged people will suffer from frailness in retirement – Daily Mail (free) AND Five modifiable risk factors found to help reach healthy old age – OnMedica (free)

Related Study: Impact of Healthy Lifestyle Factors on Life Expectancies (link to abstract and commentaries)

 

9 – Oncological outcome after MRI‐based selection for neoadjuvant chemoradiotherapy in the OCUM Rectal Cancer Trial – British Journal of Surgery (link to abstract – $ for full-text)

Commentaries: Many patients with rectal cancer may not need chemoradiotherapy – eCancer News (free) AND Limiting Chemo to High-Risk Rectal Cancer Called Feasible – MedPage Today (free registration required) AND OCUM Trial: Some Rectal Cancers Need Only Surgery – Medscape (free registration required)

 

10 – Study Guide: Rip Current Heroes Study Guide – National Geographic (free PDF)

News Release: Rip Current Heroes Study Guide (Free)

Videos: Rip Current Heroes (free)

Related Reports: Preventing drowning: an implementation guide – World Health Organization (free) AND Global report on drowning: preventing a leading killer – World Health Organization (free) AND Hidden Hazards: An Exploration of Open Water Drowning and Risks for Children – Safe Kids Worldwide (free PDF)

Source: Global Health NOW Newsletter

Each year they kill, on average, more lives in Australia than bushfires, floods, cyclones and sharks combined.
The global drowning prevention community is out to spread the word on identifying and escaping deadly rip currents with a public awareness campaign today. Check out a documentary and study guide focused on rip current science and survival strategies from National Geographic and Australia’s Rob Brander, a global expert in the field from UNSW Sydney”. (from Global Health NOW Newsletter)

 


 

1 – Heat-Stable Carbetocin versus Oxytocin to Prevent Hemorrhage after Vaginal Birth – New England Journal of Medicine (free)

Commentaries: Heat-stable drug could save thousands from post-childbirth bleeding: WHO – Reuters (free) AND Saving Moms’ Lives During Childbirth Just Got Easier – NPR (free)

 

2 – Clinical Report: The Prenatal Visit – The American Academy of Pediatrics (free)

News Release: What to cover during prenatal visit: AAP clinical report offers guidance – AAP News (free)

Commentaries: Urge expectant parents to have prenatal pediatrician visit – Pediatric News (free) AND AAP updates recommendations for prenatal visits – Healio (free registration required)

 

3 – Guideline Synopsis: Management of Ventricular Arrhythmias and Sudden Cardiac Death Risk Associated With Cardiac Channelopathies – JAMA Cardiology (free for a limited period)

Original Guideline: 2017 AHA/ACC/HRS Guideline for Management of Patients With Ventricular Arrhythmias and the Prevention of Sudden Cardiac Death – Circulation (free PDF)

 

4 – Sex‐Specific Associations Between Alcohol Consumption and Incidence of Hypertension: A Systematic Review and Meta‐Analysis of Cohort Studies – Journal of the American Heart Association (free for a limited period)

Related Study: Effects of Repeated Binge Drinking on Blood Pressure Levels and Other Cardiovascular Health Metrics in Young Adults: National Health and Nutrition Examination Survey, 2011‐2014 – Journal of the American Heart Association (free for a limited period)

Editorial: Alcohol Consumption, Hypertension, and Cardiovascular Health Across the Life Course: There Is No Such Thing as a One‐Size‐Fits‐All Approach (free)

Commentaries: Young binge drinkers may have higher heart risks – AHA Newsroom (free) AND Alcohol Intake Tied to Elevated Blood Pressure – NEJM Physician’s First Watch (free) AND Binge drinking may increase heart risks for younger people – UPI (free)

 

5 – Dietary Recommendations for Adults With Psoriasis or Psoriatic Arthritis From the Medical Board of the National Psoriasis Foundation: A Systematic Review – JAMA Dermatology (link to abstract- $ for full-text)

Commentaries: What is the Role of Diet in Psoriasis and Psoriatic Arthritis? – MedicalResearch.com (free) AND Dietary Changes Can Lessen Severity of Psoriatic Disease – Medscape (free registration required) AND Can Diet Help in Psoriasis? – MedPage Today (free registration required) AND NPF Dietary Recommendations for Psoriatic Disease – RheumNow (free)

 

6 – Perspective: FDA Repays Industry by Rushing Risky Drugs to Market – ProPublica (free)

 

7 – Society of Anesthesia and Sleep Medicine Guideline on Intraoperative Management of Adult Patients With Obstructive Sleep Apnea – Anesthesia & Analgesia (free PDF)

 

8 – Nutritional Considerations in Pediatric Pancreatitis: A Position Paper from the NASPHAN Pancreas Committee and ESPHAN Cystic Fibrosis/Pancreas Working Group – Journal of Pediatric Gastroenterology and Nutrition (free)

Commentary: Pediatric pancreatitis: nutritional care recommendations from ESPGHAN-NASPGHAN – Univadis (free registration required)

 

9 – Systemic Therapy for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

Related Guideline: Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer and Brain Metastases: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

 

10 – Association of Retinal Nerve Fiber Layer Thinning With Current and Future Cognitive Decline: A Study Using Optical Coherence Tomography – JAMA Neurology (free for a limited period)

Commentaries: Eye Sign of Dementia Risk? Thinning of Retinal Nerve Fiber Layer – MedicalResearch.com (free) AND Are the Eyes Windows to Early Dementia? – MedPage Today (free registration required)

“A thinner Retinal Nerve Fiber Layer is associated with worse cognitive function in individuals without a neurodegenerative disease as well as greater likelihood of future cognitive decline”.

 


 

1 – Screening for Osteoporosis to Prevent Fractures: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Osteoporosis (free) AND Osteoporosis Screening—2 Steps May Be Too Much for Women Younger Than 65 Years (free)

Author Interview: USPSTF Recommendation Statement: Screening for Osteoporosis to Prevent Fractures (free)

See also: USPSTF Final Recommendation Statement (free)

 

2 – The Society for Vascular Surgery practice guidelines on follow-up after vascular surgery arterial procedures – Journal of Vascular Surgery (free)

 

3 – Recurrent Glioblastoma Treated with Recombinant Poliovirus – New England Journal of Medicine (free for a limited period)

Editorial: Exploiting Viruses to Treat Diseases (free for a limited period)

Commentaries: Doctors Try Genetically Modified Poliovirus As Experimental Brain Cancer Treatment – NPR (free) AND Poliovirus therapy shows early promise in patients with aggressive brain cancer but questions linger – STAT (free)

 

4 – Closed-Loop Insulin Delivery for Glycemic Control in Noncritical Care – New England Journal of Medicine (free for a limited period)

Commentaries: Improved Glycemic Control With Closed-Loop Insulin Delivery System – Endocrinology Advisor (free) AND Closed-Loop Diabetes Systems (Artificial Pancreas) Can Be Used For Inpatient Care – MedicalResearch.com (free)

 

5 – Different defibrillation strategies in survivors after out-of-hospital cardiac arrest – Heart (free)

Commentary: Onsite defibrillators helping to increase cardiac arrest survival – Reuters (free)

Related Studies: Impact of Bystander Automated External Defibrillator Use on Outcomes (free study and commentaries) AND Use of public defibrillators linked to out-of-hospital cardiac arrest survival (link to abstract and commentaries) AND Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest (link to abstract and commentaries)

 

6 – Deprescribing Proton Pump Inhibitors – Therapeutics Initiative (free)

Related guidelines: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antihyperglycemic agents in older persons: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing antipsychotics for behavioural and psychological symptoms of dementia and insomnia: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)

 

7 – Intentional Weight Loss for Overweight and Obese Knee Osteoarthritis Patients: Is More Better? – Arthritis Care & Research (free PDF)

Commentaries: Long-term weight loss of at least 20% helps improve outcomes in overweight, obese patients with knee osteoarthritis – ACP Internist (free) AND When it comes to weight loss in overweight and obese adults with knee osteoarthritis, more is better – Wiley, via ScienceDaily (free) AND More weight loss tied to less knee pain for obese people – Reuters (free) AND More Weight Loss Linked To Greater Decrease in Knee Arthritis Pain – MedicalResearch.com (free)

 

8 – The economic cost of inadequate sleep – Sleep (free)

Commentaries: Inadequate sleep could cost countries billions – Oxford University Press USA, via EurekAlert (free) AND Wake-up call: Sleepiness ‘epidemic’ costing global economies billions – The Sidney Morning Herald (free)

 

9 – Donepezil for dementia due to Alzheimer’s disease – Cochrane Library (free)

Summary: Donepezil for people with dementia due to Alzheimer’s disease – Cochrane Library (free)

 

10 – Percutaneous Ablation Versus Partial and Radical Nephrectomy for T1a Renal Cancer: A Population-Based Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Percutaneous ablation may be preferred to nephrectomy for selected patients with early-stage renal cancer – ACP Internist (free) AND New Findings Support Ablation for Small Renal Tumors – Renal & Urology News (free)

Related Meta-Analysis: Radiofrequency ablation versus partial nephrectomy for treatment of renal masses: A systematic review and meta-analysis – The Kaohsiung Journal of Medical Sciences (free) AND Radiofrequency Ablation Versus Partial Nephrectomy in Treating Small Renal Tumors: A Systematic Review and Meta-Analysis – Medicine (free)

“Percutaneous ablation for T1a renal cancer has similar 5-year survival rates to radical nephrectomy but with far fewer 30-day complications and less kidney failure (via @AnnalsofIM see Tweet)

 


 

1 – Association of a Bundled Hospital-at-Home and 30-Day Postacute Transitional Care Program With Clinical Outcomes and Patient Experiences – JAMA Internal Medicine (free for a limited period)

Editorial: Hospital-at-Home Care Programs—Is the Hospital of the Future at Home? (free for a limited period)

Author Interview: Association of a Bundled Hospital-at-Home Program With Clinical Outcomes and Patient Experiences (free)

Commentaries: Hospital-at-Home Bundled Program Associated With Better Clinical Outcomes, Patient Experiences – AJMC (free) AND Clinical outcomes and patient experiences vastly improved with hospital at home – The Mont Sinai Hospital, via MedicalXpress (free) AND Hospital-at-Home Care a Potential Alternative to Inpatient Care – Physician’s First Watch (free)

 

2 – Advance care planning in dementia: recommendations for healthcare professionals – BMC Palliative Care (free)

Related: New Document for Patients: Advanced Health Directive for Dementia (free document and commentaries) AND Alzheimer’s? Your Paperwork May Not Be in Order – The New York Times (10 articles per month are free)

 

3 – Errors in estimating usual sodium intake by the Kawasaki formula alter its relationship with mortality: implications for public health – International Journal of Epidemiology (link to abstract – $ for full-text)

Commentaries: Accurate measurements of sodium intake confirm relationship with mortality – ScienceDaily (free) AND Better estimate of intake more firmly links salt, death – UPI (free)

Related Report: Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks – Agency for Healthcare Research and Quality (free)

 

4 – Saline irrigation for allergic rhinitis – Cochrane Library (free)

Summary: Nasal saline for allergic rhinitis – Cochrane Library (free)

 

5 – Richard Lehman’s journal review, 25 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 

6 – Update on difficult airway management with a proposal of a simplified algorithm, unified and applied to our daily clinical practice – Colombian Journal of Anesthesiology (free)

Related Guidelines: Difficult Airway Society 2015 guidelines for management of unanticipated difficult intubation in adults – British Journal of Anaesthesia (free) AND Practice Guidelines for Management of the Difficult Airway: An Updated Report by the American Society of Anesthesiologists Task Force on Management of the Difficult Airway – Anesthesiology (free)

Source: Critical Care Reviews Newsletter

 

7 – Robot-assisted radical cystectomy versus open radical cystectomy in patients with bladder cancer (RAZOR): an open-label, randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Robotic, Open Cystectomy Offer Comparable Bladder Cancer Outcomes – Renal & Urology News (free) AND RAZOR study: No differences in robotic vs open surgery for bladder cancer – Coloproctology News (free) AND Robotic surgery is no better than traditional surgery, bladder cancer study finds – The Washington Post (free)

 

8 – A Randomized Controlled Trial of Parent-Child Psychotherapy Targeting Emotion Development for Early Childhood Depression – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Parent-Child Psychotherapy Leads to Improvements in Young Children With Depression – Psychiatric News Alert (free) AND Psychotherapeutic intervention shows promise for treating depression in preschool-aged children – NIH News Releases (free) AND Parent-child therapy helps young children with depression – Washington University School of Medicine, via ScienceDaily (free)

Related Study: Talking therapy given by parents shows promise for childhood anxiety disorders (free research, editorial and commentaries)

 

9 – Association Between Oxygen Saturation Targeting and Death or Disability in Extremely Preterm Infants in the Neonatal Oxygenation Prospective Meta-analysis Collaboration – JAMA (link to abstract – $ for full-text)

Commentaries: Oxygen for preterm infants, what dose of this toxic drug is the right dose? #NeoEBM – Neonatal Research (free) AND Lower and higher oxygen saturation targets result in equal but contrasting outcomes for extremely preterm infants – 2 Minute Medicine (free)

 

10 – Association Between Portable Music Player Use and Hearing Loss Among Children of School Age in the Netherlands – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)

Commentaries: Portable music players tied to hearing loss in kids – Reuters (free) AND Portable Music Player Use Linked to Hearing Loss in Children – MPR (free)

 


 

1 – Diarrhoea in adult cancer patients: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

 

2 – Neonatal interventions for preventing cerebral palsy: an overview of Cochrane Systematic Reviews – Cochrane Library (free)

Summary: Interventions for babies from birth to one month of life for preventing cerebral palsy: an overview of Cochrane Systematic Reviews (free)

 

3 – Prophylactic abdominal drainage for pancreatic surgery – Cochrane Library (free)

Summary: Drain use after pancreatic surgery – Cochrane Library (free)

 

4 – Resuscitation Education Science: Educational Strategies to Improve Outcomes From Cardiac Arrest: A Scientific Statement From the American Heart Association – Circulation (free PDF)

See also: Highlights (free PDF) AND FAQs (free PDF) AND Infographic (free PDF)

 

5 – Perspective: Breathing Tubes Fail to Save Many Older Patients – The New York Times (10 articles per month are free)

“One-third of patients over age 65 die in the hospital after they are put on ventilators. Doctors are beginning to wonder if the procedure should be used so often”.

 

6 – Core Competencies in Evidence-Based Practice for Health Professionals: Consensus Statement Based on a Systematic Review and Delphi Survey – JAMA Network Open (free)

Editorial: Interprofessional Evidence-Based Practice Competencies: Equalizing the Playing Field (free)

“68 core competencies for evidence-based practice for health professionals, developed using systematic review & Delphi consensus process” (via @hildabast see Tweet)

 

7 – Association of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes – JAMA (free for a limited period)

Editorial: Revisiting NPH Insulin for Type 2 Diabetes: Is a Step Back the Path Forward? (free for a limited period)

Clinical Review Audio: Health Care Spending Gone Wild: Using Expensive Insulin Analogs With Few Clinical Advantages (free)

“Long-acting insulin analogs not associated with reduced hypoglycemia-related ED visits or hospital admissions when compared with NPH insulin, despite costing 5-10x as much” (via @jsross119 see Tweet)

 

8 – Long-term albumin administration in decompensated cirrhosis (ANSWER): an open-label randomised trial – The Lancet (link to abstract – $ for full-text)

Commentary: Spotlight on albumin in cirrhosis – ACP Gastroenterology (free)

 

9 – Sodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: BICAR-ICU – The Bottom Line (free)

This study will reassure clinicians that already use sodium bicarbonate for correcting metabolic acidaemia, that this may delay and/or reduce the requirement for RRT. Equally, for those that opt to avoid sodium bicarbonate, there is no compelling evidence to change practice” (from The Bottom Line)

 

10 – Determinants of long-term clinical outcomes in patients with angina but without obstructive coronary artery disease: a systematic review and meta-analysis – European Heart Journal (free)

Commentaries: Outcomes in Patients With Angina but Without Obstructive CAD – American College of Cardiology (free)

 


 

1 – Report: Sodium and Potassium Intake: Effects on Chronic Disease Outcomes and Risks – Agency for Healthcare Research and Quality (free)

See also: Evidence Summary (free PDF) AND Full Report (free PDF)

 

2 – NICE Guideline: Hearing loss in adults: assessment and management – National Institute for Health and Care Excellence (free)

 

3 – Conventional and biologic disease-modifying anti-rheumatic drugs for osteoarthritis: a meta-analysis of randomized controlled trials – Rheumatology (free)

Commentary: OA: DMARDs fail to relieve pain in meta-analysis – Univadis (free registration required)

 

4 – Presented at EULAR 2018: NSAIDs Account for Large Part of Osteoarthritis-CVD Link, Study Suggests – TCTMD (free)

 

5 – Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss – New England Journal of Medicine (link to abstract – $ for full-text)

Quick Take Video Summary: Sodium Thiosulfate for Cisplatin-Induced Hearing Loss (free)

Commentaries: New drug halves hearing loss in children following cancer treatment – Cancer Research UK, via ScienceDaily (free) AND Otoprotectant Guards Against Cisplatin-Induced Hearing Loss – Medscape (free registration required) AND Antioxidant Cuts Hearing Loss in Cisplatin-Treated Kids – MedPage Today (free registration required)

 

6 – Review: What’s new in severe pulmonary embolism? – Intensive Care Medicine (free for a limited period) (via @srrezaie)

 

7 – Perspective: This Mediterranean diet study was hugely impactful. The science just fell apart – VOX (free)

See Related Retraction and Republication: PREDIMED Study on Mediterranean Diet (free article and commentaries)

 

8 – Perspective: To Fight Burnout, Organize – New England Journal of Medicine (free)

The social determinants of health — and physicians’ sense of powerlessness in the face of them — seem crucially missing from the discussion of burnout”.

 

9 – Review: Acute myocardial infarction in young women: current perspectives – International Journal of Women’s Health (free)

Related Review: Young Women With Acute Myocardial Infarction: Current Perspectives – Circulation: Cardiovascular Quality and Outcomes (free)

Related Guideline: Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association – Circulation (free)

 

10 – Review: Managing patients with chronic cough: challenges and solutions – Therapeutics and Clinical Risk Management (free)

See also recently published CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Cough Due to TB and Other Chronic Infections  (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)

 


 

1 – Bologna guidelines for diagnosis and management of adhesive small bowel obstruction (ASBO): 2017 update of the evidence-based guidelines from the world society of emergency surgery ASBO working group – World Journal of Emergency Surgery (free)

 

2 – NICE Guideline: Dementia: assessment, management and support for people living with dementia and their carers – National Institute for Health and Care Excellence (free)

 

3 – The association of lifetime alcohol use with mortality and cancer risk in older adults: A cohort study – PLOS Medicine (free)

Commentaries: Risks of cancer and mortality by average lifetime alcohol intake – PLOS, via ScienceDaily (free) AND Drinking Alcohol Can Raise Cancer Risk. How Much Is Too Much? – NPR (free) AND Light drinkers at a lower combined risk of earlier death or developing cancer – The Conversation (free) AND Expert reaction to the association between lifetime drinking and mortality and cancer risk – Science Media Centre (free)

Related Meta-analysis: Risk Thresholds for Alcohol Consumption (free study, editorial and commentaries)

 

4 – Association of Stress-Related Disorders With Subsequent Autoimmune Disease – JAMA (link to abstract – $ for full-text)

Commentaries: Association of Stress-Related Disorders With Subsequent Autoimmune Disease – University of Iceland (free) AND Stress disorders tied to increased risk of autoimmune diseases – Reuters (free) AND Does Psychological Stress Trigger Autoimmune Disorders? – MedPage Today (free registration required)

 

5 – Pancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort – Journal of the National Cancer Institute (link to abstract – $ for full-text)

Commentaries: Diabetes may be an early manifestation of pancreatic cancer – eCancer News (free) AND Recent-onset diabetes linked to pancreatic cancer for some minorities – UPI (free) AND Diabetes after 50 could be early sign of pancreatic cancer, study says – CNN (free)

 

6 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)

Commentary: Ebola outbreak in Congo ‘largely contained’, says WHO – Reuters (free)

 

7 – The venous ulcer continues to be a clinical challenge: an update – Burns & Trauma (free)

Related Cochrane Review: Dressings and topical agents for treating venous leg ulcers (free) AND Summary (free)

 

8 – Long-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction – JAMA Surgery (free for a limited period)

Invited Commentary: Autologous vs Prosthetic Breast Reconstruction: Where Do We Stand? (free for a limited period)

Author Interview: Long-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction (free audio)

Commentaries: Breast reconstruction more satisfying than implants after cancer, survey says – UPI (free) AND Flap vs Implant for Breast Reconstruction: How to Choose – MedPage Today (free registration required) AND Study explores satisfaction, quality of life after breast reconstruction – Brigham and Women’s Hospital, via MedicalXpress (free)

 

9 – Idiopathic intracranial hypertension: consensus guidelines on management – Journal of Neurology, Neurosurgery & Psychiatry (free) 

 

10 – Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study – Journal of Clinical Psychopharmacology (link to abstract – $ for full-text)

Commentaries: Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants – MPR (free) AND Antidepressants tied to Parkinson’s-like symptoms – Univadis (free registration required)

“Observational study: Incidence of EPSs with antidepressants. RRs: duloxetine, 5.68; mirtazapine, 3.78; citalopram, 3.47; escitalopram, 3.23; paroxetine, 3.07; sertraline, 2.57; venlafaxine, 2.37; bupropion, 2.31; and fluoxetine, 2.03 (all significant)” (via @psychopharmacol see Tweet)