TOP 10 Medical News Stories

Fri, March 22 – 10 Stories of The Day!

22 Mar, 2019 | 07:42h | UTC


1 – Clinical Practice Guideline for the Management of Asymptomatic Bacteriuria: 2019 Update by the Infectious Diseases Society of America – Clinical Infectious Diseases (free)

Commentaries: Bacteria in urine doesn’t always indicate infection – Infectious Diseases Society of America (free) AND Most Urinary Bacteria Do Not Require Antibiotics – (free)


2 – Schedules for Self-monitoring Blood Pressure: A Systematic Review – American Journal of Hypertension (free)

Home blood pressure should be measured for 3 days, increased to 7 only when mean blood pressure is close to a diagnostic or treatment threshold.”


3 – Building a tuberculosis-free world: The Lancet Commission on tuberculosis (free articles – registration required)

Commentaries: Experts set out targets to eliminate tuberculosis within a generation – The Lancet (free) AND A human-rights approach is essential to end the global TB epidemic – The Conversation (free) AND A Roadmap for Ending the Moral Catastrophe of TB – Global Health NOW (free)


4 – Evaluation of the Collaborative Use of an Evidence-Based Care Bundle in Emergency Laparotomy – JAMA Surgery (free)

“A collaborative approach using a quality improvement methodology and a care bundle appeared to be effective in reducing mortality and length of stay in emergency laparotomy”.


5 – OBesity Treatment, Beyond the Guidelines: Practical Suggestions for Clinical Practice – JAMA (free for a limited period)

Related: European Practical and Patient-Centred Guidelines for Adult Obesity Management in Primary Care – Obesity Facts (free)


6 – AMSSM position statement update: blood-borne pathogens in the context of sports participation – British Journal of Sports Medicine (free)


7 – Opting Out of Vaccines Should Opt You Out of American Society – Scientific American (free)

Although you have a right to your own body, your choice to willfully be sick ends where another’s right to be healthy begins.”


8 – A prospective study of tea drinking temperature and risk of esophageal squamous cell carcinoma – International Journal of Cancer (free)

Commentaries: Expert reaction to research on hot tea and oesophageal cancer – Science Media Centre (free) AND Drinking hot tea linked with elevated risk of esophageal cancer – Wiley (free) AND Drinking very hot tea almost doubles risk of cancer, new study says – CNN (free) AND Hot tea linked to increased risk of esophageal cancer – UPI (free)


9 – Ultrasound guidance in difficult radial artery puncture for blood gas analysis: A prospective, randomized controlled trial – PLOS One (free)


10 – Performance of Screening Ultrasonography as an Adjunct to Screening Mammography in Women Across the Spectrum of Breast Cancer Risk – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Breast Screening: Adding Ultrasonography Doesn’t Seem Worth Associated Harms – NEJM Journal Watch (free) AND Does supplemental whole-breast ultrasound provide significant value? – Radiology Business (free)


Thu, March 21 – 10 Stories of The Day!

21 Mar, 2019 | 07:25h | UTC


1 – WHO consolidated guidelines on drug-resistant tuberculosis treatment – World Health Organization (free PDF)

News Release: New WHO recommendations to accelerate progress on TB – World Health Organization (free)


2 – WHO expert panel paves way for strong international governance on human genome editing – World Health Organization (free)

Commentaries: World Health Organization advisers call for registry of studies on human genome editing – STAT (free) AND W.H.O. Panel Demands a Registry for Human Gene Editing – The New York Times (10 articles per month are free) AND World Health Organization panel weighs in on CRISPR-babies debate – Nature (free)


3 – Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis – Blood Advances (free)

Our findings indicate that patients on VKA therapy who have an INR between 4.5 and 10.0 without bleeding are not likely to benefit from vitamin K administration in addition to temporary VKA cessation.”


4 – Podcast: Update on Atrial Fibrillation: Review of the New AHA/ACC/HRS Treatment Guidelines (free)


5 – Perspective: Mesh Implants for Women: Scandal or Standard of Care? – JAMA (free for a limited period)

“Urogyne mesh implants have been called the “biggest medical scandal” since thalidomide and the “gold standard” treatment for stress urinary incontinence. These divergent views illustrate the complexity of the ongoing debate over their safety and efficacy.” (via @JAMA_current see Tweet)


6 – Clinical practice guidelines and the overuse of health care services: need for reform – Canadian Medical Association Journal (free for a limited period)

Specialty bias and fee-for-service conflicts of interest threaten the validity of clinical practice guidelines and may lead to overdiagnosis, overtreatment and increasing health care costs.”


7 – Scientists rise up against statistical significance – Nature (free)

Editorial: It’s time to talk about ditching statistical significance – Nature (free)

Related: What a nerdy debate about p-values shows about science — and how to fix it – VOX (free) AND Big names in statistics want to shake up much-maligned P value – Nature News (free) AND ‘One-size-fits-all’ threshold for P values under fire – Nature News (free) AND Statisticians issue warning over misuse of P values – Nature News (free) AND Understanding common misconceptions about p-values – The 20% Statistician (free) AND PulmCrit- .050 shades of grey in p-value cutoffs (free) AND Statistical tests, P values, confidence intervals, and power: a guide to misinterpretations – European Journal of Epidemiology(free)

“We are not calling for a ban on P values. . . Rather, and in line with many others over the decades, we are calling for a stop to the use of P values in the conventional, dichotomous way.” (via @ericmjohnson)


8 – The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study – The Lancet Psychiatry (free)

Commentaries: Cannabis and psychosis: triangulating the evidence – The Lancet Psychiatry (free) AND Expert reaction to daily cannabis use, potency and psychosis – Science Media Centre (free) AND Daily or high-potency cannabis increases risk of psychotic disorder, study finds – CNN (free) AND Daily cannabis and skunk users run higher psychosis risk – Reuters (free)


9 – Psychosis with Methylphenidate or Amphetamine in Patients with ADHD – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Some ADHD medicines may increase psychosis more than others, ‘real-world’ data show – STAT (free) AND With ADHD, amphetamine has double the psychosis risk of methylphenidate – Reuters (free) AND Big data study identifies drugs that increase risk of psychosis in youth with ADHD – McLean Hospital (free)


10 – Long-Term Consumption of Sugar-Sweetened and Artificially Sweetened Beverages and Risk of Mortality in US Adults – Circulation (free PDF)

Commentaries: ‘Just one sugary drink a day’ linked to health problems – NHS Choices (free) AND Sugary drinks linked to higher risk of premature death, especially for women, study says – CNN (free) AND Sugary drinks could raise risk of early deaths finds study – News Medical (free)


Wed, March 20 – 10 Stories of The Day!

20 Mar, 2019 | 03:39h | UTC


1 – Anticonvulsant Prophylaxis and Steroid Use in Adults With Metastatic Brain Tumors: ASCO and SNO Endorsement of the Congress of Neurological Surgeons Guidelines – Journal of Clinical Oncology (free)


2 – Comparison of Dual Therapies for Lowering Blood Pressure in Black Africans – New England Journal of Medicine (free for a limited period)

Commentary: Two-Drug Combos Using Popular Calcium Channel Blocker Show Superiority in Lowering Blood Pressure – American College of Cardiology (free)


3 – High-Dose Nifedipine Tied to Higher Cardiac Arrest Risk – TCTMD (free)

See also: Nifedipine linked with cardiac arrest – Pharmacy News (free) AND Common blood pressure drug may increase cardiac arrest risk – Medical News Today (free)


4 – Diagnostic Test Interpretation: Evaluating the Erythrocyte Sedimentation Rate – JAMA (free for a limited period)


5 – Outpatient treatment for people with cancer who develop a low‐risk febrile neutropaenic event – Cochrane Library (free)

Summary: Outpatient treatment for cancer patient with low-risk febrile neutropaenic event is effective – Cochrane Library (free)

Related Guideline: Outpatient Management of Fever and Neutropenia in Adults Treated for Malignancy: American Society of Clinical Oncology and Infectious Diseases Society of America Clinical Practice Guideline Update – Journal of Clinical Oncology (free) 


6 – Pharmacologic and Nonpharmacologic Treatments for Urinary Incontinence in Women: A Systematic Review and Network Meta-analysis of Clinical Outcomes – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Behavioral therapy appears more effective than pharmacologic therapy for urinary incontinence outcomes – ACP Internist (free) AND For Urinary Incontinence, Behavioral Therapies Outperform Meds – NEJM Journal Watch (free)


7 – Best Practices for Evaluation and Treatment of Agitated Children and Adolescents (BETA) in the Emergency Department: Consensus Statement of the American Association for Emergency Psychiatry – West Journal of Emergency Medicine (free)


8 – Age, period, and cohort trends in mood disorder indicators and suicide-related outcomes in a nationally representative dataset, 2005–2017 – Journal of Abnormal Psychology (free PDF)

Commentaries: A Rise In Depression Among Teens And Young Adults Could Be Linked To Social Media Use – NPR (free) AND Mental health issues increased significantly in young adults over last decade – American Psychological Association (free)


9 – Levels of Evidence Supporting American College of Cardiology/American Heart Association and European Society of Cardiology Guidelines, 2008-2018 – JAMA (link to abstract – $ for full-text)

Commentaries: Many Guidelines For Heart Care Rely On Weak Evidence – NPR (free) AND Few heart care recommendations are based on rigorous study – News Medical (free)


10 – Diagnostic Accuracy of Point-of-Care Lung Ultrasonography and Chest Radiography in Adults With Symptoms Suggestive of Acute Decompensated Heart Failure: A Systematic Review and Meta-analysis – JAMA Network Open (free)

The findings suggest that Lung Ultrasonography is more sensitive than Chest Radiography in detecting pulmonary edema in ADHF”


Tue, March 19 – 10 Stories of The Day!

19 Mar, 2019 | 03:54h | UTC


1 – Coronary Angiography after Cardiac Arrest without ST-Segment Elevation – New England Journal of Medicine (free for a limited period)

Editorial: Coronary Angiography after Cardiac Arrest — The Right Timing or the Right Patients? (free for a limited period)

Commentaries: Angiography timing does not impact survival after cardiac arrest for NSTEMI patients – American College of Cardiology (free) AND COACT: Delayed Angiography Does Not Compromise Survival in Cardiac Arrest Patients Without STEMI – TCTMD (free)


2 – Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation – New England Journal of Medicine (free for a limited period)

Editorial: The RACE to Treat Atrial Fibrillation in the Emergency Department (free for a limited period)

Commentary: For Acute A-fib, Wait-and-See Approach May Spare Many Patients from Cardioversion – TCTMD (free)


3 – Management of asymptomatic arrhythmias: a European Heart Rhythm Association (EHRA) consensus document, endorsed by the Heart Failure Association (HFA), Heart Rhythm Society (HRS), Asia Pacific Heart Rhythm Society (APHRS), Cardiac Arrhythmia Society of Southern Africa (CASSA), and Latin America Heart Rhythm Society (LAHRS) – EP Europace (free)


4 – Guidelines for Antibiotic Prescription in Intensive Care Unit – Indian Journal of Critical Care Medicine (free PDF)

Source: Critical Care Reviews Newsletter

Comprehensive guideline covering many common conditions in the Critical Care Unit.


5 – Indian Antimicrobial Prescription Guidelines in Critically Ill Immunocompromised Patients – Indian Journal of Critical Care Medicine (free PDF)

Source: Critical Care Reviews Newsletter


6 – Multiple‐micronutrient supplementation for women during pregnancy – Cochrane Library (free)

Summary: Vitamin and mineral supplements for women during pregnancy – Cochrane Library (free)


7 – The Effects of Early Nutritional Interventions on the Development of Atopic Disease in Infants and Children: The Role of Maternal Dietary Restriction, Breastfeeding, Hydrolyzed Formulas, and Timing of Introduction of Allergenic Complementary Foods – Pediatrics (free)

Commentaries: Dietary interventions to prevent atopic disease: Updated recommendations – American Academy of Pediatrics (free) AND There’s new advice to prevent food allergies in children – CNN (free)


8 – Christopher Martyn’s research reviews, 18 March 2019 – The BMJ Opinion (free)


9 – British HIV Association guidelines for the management of HIV in pregnancy and postpartum 2018 – HIV Medicine (free)


10 – BHIVA/BASHH guidelines on the use of HIV pre–exposure prophylaxis (PrEP) 2018 – HIV Medicine (free)

Related guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Draft Recommendation Statement: Prevention of Human Immunodeficiency Virus (HIV) Infection: Pre-Exposure Prophylaxis – U.S. Preventive Services Task Force (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Australasian Society for HIV, Viral Hepatitis and Sexual Health Medicine HIV pre-exposure prophylaxis: clinical guidelines. Update April 2018 – Journal of Virus Eradication (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)


Mon, March 18 – 10 Stories of The Day!

18 Mar, 2019 | 00:17h | UTC


1 – 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – Journal of the American College of Cardiology (free PDF)

Guideline Hub: Primary Prevention of Cardiovascular Disease (free resources)

Executive Summary: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease (free PDF)

Guidelines Made Simple: A Selection of Tables and Figures (free PDF)

Summary with Key Points to Remember: 2019 ACC/AHA Guideline on the Primary Prevention of Cardiovascular Disease – American College of Cardiology (free)


2 – Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial – JAMA (free for a limited period)

Related Study: Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial – JAMA (free for a limited period)

Video Summary: Catheter Ablation vs Drug Therapy for Patients With Atrial Fibrillation: The CABANA Trial (free)

Editorial: Catheter Ablation for Atrial Fibrillation: Lessons Learned From CABANA (free for a limited period)

Commentary: Surgery no better than medication at preventing serious complications of atrial fibrillation – NIH News Releases (free)


3 – Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients – New England Journal of Medicine (free for a limited period)

Commentary: In study, TAVR is superior to surgery for low-risk patients with aortic valve stenosis – Columbia University Irving Medical Center (free)

“”The main limitation of the study is that the current results reflect outcomes after one year, which isn’t long enough to assess the long-term durability of the replacement valve,” said Leon. “Patients in the study will be followed for at least 10 years so that we can measure their long-term outcomes and inform the medical community.” (from Columbia University)


4 – Giant study shows Apple Watch can spot heart rhythm changes — but it’s far from ‘medical-grade technology’ – STAT (free)

See also: Beware the hype over the Apple Watch heart app. The device could do more harm than good – STAT (free) AND Apple Watch may spot heart problem but more research needed – Associated Press (free) AND Apple Watch May Detect A-fib in the General Population, but at What Cost? – TCTMD (free)

Related: Editorial: Downsides of Detecting Atrial Fibrillation in Asymptomatic Patients (free) AND USPSTF Statement: Screening with Resting or Exercise Electrocardiography (ECG) Not Recommended (free Guideline and commentaries) AND Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? (free commentaries) AND Get Ready For A Tsunami Of ECGs (free commentaries)


5 – True 99th centile of high sensitivity cardiac troponin for hospital patients: prospective, observational cohort study – The BMJ (free)

Commentaries: Evaluate Troponin Results Carefully, Researchers Warn – NEJM Journal Watch (free) AND Blood test to diagnose heart attacks is flawed, warn researchers – The BMJ (free) AND CHARIOT: 1 in 20 Hospitalized Patients Undergoing Blood Tests Have Elevated Troponin – TCTMD (free)

Related: Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival (free study and commentaries)


6 – Patient Blood Management Recommendations From the 2018 Frankfurt Consensus Conference – JAMA (free for a limited period)


7 – Review: Acute Respiratory Distress Syndrome – Nature Reviews Disease Primer (free PDF)


8 – Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality – JAMA (free for a limited period)

Commentaries: Are Eggs Good Or Bad? How You Should Interpret This Latest Study – Forbes (free) AND Are eggs good or bad for you? New research rekindles the debate – STAT (free) AND Eggs are bad – then good – then bad again? What gives? – Diet Doctor (free)


9 – An environmental cleaning bundle and health-care-associated infections in hospitals (REACH): a multicentre, randomised trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)

Commentary: Hospital cleaning trial cuts infections – Queensland University of Technology (free)


10 – Chlorhexidine versus routine bathing to prevent multidrug-resistant organisms and all-cause bloodstream infections in general medical and surgical units (ABATE Infection trial): a cluster-randomised trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Results of Trial to Stem Hospital-Acquired Bacterial Infections Published – NIAID (free) Quick Take: Chlorhexidine Versus Routine Bathing to Prevent Multidrug-Resistant Organisms and All-Cause Bloodstream Infections in General Medical and Surgical Units (ABATE Infection Trial) – 2 Minute Medicine (free) AND Infection control technique may reduce infections in patients with catheters, drains – Rush University Medical Center (free)

“Decolonisation with universal chlorhexidine bathing and targeted mupirocin for MRSA carriers did not significantly reduce multidrug-resistant organisms in non-critical-care patients.”


Fri, March 15 – 10 Stories of The Day!

15 Mar, 2019 | 04:29h | UTC


1 – Delirium: prevention, diagnosis and management – National Institute for Health and Care Excellence (free)

Related: SIGN Guideline: Risk Reduction and Management of Delirium (free)


2 – A Trial of a Shorter Regimen for Rifampin-Resistant Tuberculosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: STREAM trial final results show 9-month treatment for multi-drug resistant TB is as effective as 24-month treatment – University College London (free) AND Trial data support shorter drug-resistant TB regimen – CIDRAP (free)


3 – Decision Making for Older Adults With Multiple Chronic Conditions: Executive Summary for the American Geriatrics Society Guiding Principles on the Care of Older Adults With Multimorbidity – Journal of the American Geriatrics Society (free)

News Release: AGS releases new action steps to guide care for older adults with multiple chronic illnesses – American Geriatrics Society (free)


4 – Patient blood management in obstetrics: prevention and treatment of postpartum haemorrhage. A NATA consensus statement – Blood Transfusion (free)


5 – Continuous Renal Replacement Therapy: Who, When, Why, and How – Chest (free)


6 – Perspective: The Case for Being a Medical Conservative – The American Journal of Medicine (free for a limited period)


7 – Systolic Blood Pressure and Cognitive Decline in Older Adults with Hypertension – Annals of Family Medicine (free)

Commentary: Lower BP Linked to Cognitive Decline in Frail Elderly – Medscape (free registration required)

Related: Cohort Study: Control of Blood Pressure and Risk of Mortality in a Cohort of Older Adults (link to abstract and commentary)


8 – Efficacy and risk of harms of repeat ivermectin mass drug administrations for control of malaria (RIMDAMAL): a cluster-randomised trial – The Lancet (free)

Commentaries: Advancing the repurposing of ivermectin for malaria – The Lancet (free) AND Mosquito-killing drug reduces malaria episodes by a fifth among children – expert comment – London School of Hygiene & Tropical Medicine (free)


9 – Treatment, prevention and public health management of impetigo, scabies, crusted scabies and fungal skin infections in endemic populations: a systematic review – Tropical Medicine & International Health (free)


10 – Adopt a moratorium on heritable genome editing – Nature (free)

Editorial: Germline gene-editing research needs rules (free)

Commentaries: Leading scientists, backed by NIH, call for a global moratorium on creating ‘CRISPR babies’ – STAT (free) AND Expert reaction to a call for a moratorium on heritable genome editing – Science Media Centre (free)

Related: Genome-Edited Baby Provokes International Outcry (free commentaries) AND Consensus Statement on the Reported Birth of Genome-Edited Babies in China (free)


Thu, March 14 – 10 Stories of The Day!

14 Mar, 2019 | 01:15h | UTC


1 – One Month of Rifapentine plus Isoniazid to Prevent HIV-Related Tuberculosis – New England Journal of Medicine (free for a limited period)

Editorial: Ending Tuberculosis through Prevention (free)

Commentary: Ultrashort TB Therapy Found Just As Effective as 6 Month Course – (free)


2 – A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery – New England Journal of Medicine (free for a limited period)

Video Summary: Prophylactic Antibiotics before Miscarriage Surgery (free)

Commentaries: Research shines light on preventing infection after miscarriage – University of Birmingham (free) AND Antibiotics before miscarriage surgery not tied to fewer infections – CIDRAP (free)


3 – Progress in adolescent health and wellbeing: tracking 12 headline indicators for 195 countries and territories, 1990–2016 – The Lancet (free)

Commentaries: Improving adolescent health: an evidence-based call to action – The Lancet (free) AND The Lancet: Disease, violence and inequality threaten more adolescents worldwide than ever before – The Lancet (free) AND The world’s adolescents: large unmet needs and growing inequalities – University of Melbourne (free) AND Adolescent health, education needs unmet in many countries, study says – UPI (free)


4 – Trends in cause-specific mortality among children aged 5–14 years from 2005 to 2016 in India, China, Brazil, and Mexico: an analysis of nationally representative mortality studies – The Lancet (free)

Commentaries: Shedding light on a million annual deaths in mid-childhood – The Lancet (free) AND Most deaths in children aged 5 to 14 in India, China, Brazil, Mexico are preventable – St. Michael’s Hospital (free)


5 – Risk reduction and management of delirium – Scottish Intercollegiate Guidelines Network (SIGN) (free guideline and summary)

News Release: First delirium clinical guidelines for Scotland published on World Delirium Awareness Day (free)


6 – EAN guideline on trigeminal neuralgia – European Journal of Neurology (free PDF)


7 – Narrative review: clinical assessment of peripheral tissue perfusion in septic shock – Annals of Intensive Care (free)

Related Research: Randomized Trial: Resuscitation Strategy Targeting Peripheral Perfusion Status vs Serum Lactate Levels in Patients with Septic Shock (link to abstract $ for full-text)


8 – Pro/Con Debate: Should Asymptomatic Patients with Moderate-to-severe OSA be Treated?

Pro: should asymptomatic patients with moderate-to-severe OSA be treated? – Breathe (free)

Con: should asymptomatic patients with moderate-to-severe OSA be treated? – Breathe (free)

Related: Obstructive Sleep Apnea in Cardiovascular Disease: A Review of the Literature and Proposed Multidisciplinary Clinical Management Strategy (free reviews) AND Positive airway pressure doesn’t reduce cardiovascular events and death in adults with sleep apnea (link to abstract and commentaries)


9 – Ten myths around open scholarly publishing – PeerJ Preprints (free)

Related: UC Terminates Subscriptions with World’s Largest Scientific Publisher in Push for Open Access (several commentaries on the subject)


10 – Infections in Solid Organ Transplantation – Guidelines from the American Society of Transplantation Infectious Diseases Community of Practice (free PDF articles)

– BK Polyomavirus in Solid Organ Transplantation

– Adenovirus in Solid Organ Transplant Recipients

– Mycobacterium tuberculosis Infections in Solid Organ Transplantation

– Nocardia Infections in Solid Organ Transplantation

– Urinary Tract Infections in Solid Organ Transplant Recipients

– Viral Hepatitis

– Herpes Simplex Virus Infections in Solid Organ Transplantation

– RNA Respiratory Viral Infections in Solid Organ Transplant Recipients

– Interactions between Anti‐infective Agents and Immunosuppressants

– Travel Medicine, Transplant Tourism, and the Solid Organ Transplant Recipient

– Solid Organ Transplantation in the HIV‐Infected Patient

– Cytomegalovirus in Solid Organ Transplant Recipients

– Human Herpesvirus 6, 7 and 8 in Solid Organ Transplantation

– Strategies for Safe Living Following Solid Organ Transplantation

– Emerging Fungal Infections in Solid Organ Transplant Recipients


Wed, March 13 – 10 Stories of The Day!

13 Mar, 2019 | 06:15h | UTC


1 – Cardiovascular disease burden from ambient air pollution in Europe reassessed using novel hazard ratio functions – European Heart Journal (free)

Commentaries: Air pollution causes 8.8 million extra early deaths a year – European Society of Cardiology (free) AND Air Pollution Causes 8.8 Million Extra Deaths a Year – U.S. News (free) AND Air pollution kills 8.8 million people per year globally, study says – UPI (free)

Related: 9 out of 10 people worldwide breathe polluted air, but more countries are taking action – World Health Organization (free) AND The cost of a polluted environment: 1.7 million child deaths a year, says WHO – World Health Organization (free) AND Estimates and 25-year trends of the global burden of disease attributable to ambient air pollution: an analysis of data from the Global Burden of Diseases Study 2015 – The Lancet (free) AND Death in the Air: Air Pollution Costs Money and Lives – World Bank (free infographic and report)


2 – Evidence evolving on aspirin as prevention – ACP Internist (free)

Related: Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease (link to abstract and commentaries) AND Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes (link to abstract and commentaries) AND Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly (link to abstract and commentaries) AND Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events (link to abstract and commentaries)

In patients who have not had a prior cardiovascular event, aspirin’s protective effects are modest and may not necessarily outweigh its potential downsides (namely, risk of bleeding and hemorrhagic stroke).”


3 – Low Back Pain, a Comprehensive Review: Pathophysiology, Diagnosis, and Treatment. – Current Pain and Headache Reports (free)


4 – Italy bans unvaccinated children from school – BBC (free)


5 – Randomized Trial of Four Treatment Approaches for Actinic Keratosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Comparison of Four Treatments for Actinic Keratosis – NEJM Resident 360 (free) AND Actinic keratosis: fluorouracil cream tops other options in randomized trial – Univadis (free registration required)


6 – Podcast: #142 Cirrhosis TIPS for Acute Complications – The Curbsiders Internal Medicine Podcast (free)

See also: Episode List


7 – Perioperative care of cannabis users: A comprehensive review of pharmacological and anesthetic considerations – Journal of Clinical Anesthesia (free)


8 – ‘Test and Treat’ reduces new HIV infections by a third in southern Africa communities – London School of Hygiene & Tropical Medicine (free)

See also: Largest ever HIV prevention study delivers sobering message – Science (free)


9 – Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Commentary: The global burden of stroke: persistent and disabling – The Lancet Neurology (free)


10 – Sensitization in Heart Transplantation: Emerging Knowledge: A Scientific Statement From the American Heart Association – Circulation (free PDF)

Commentary: Navigating Allosensitization in Heart Transplant Candidates and Recipients – American Heart Association (free)

Top Ten Things to Know: Sensitization in Heart Transplantation: Emerging Knowledge – American Heart Association (free)


Tue, March 12 – 10 Stories of The Day!

12 Mar, 2019 | 03:00h | UTC


1 – Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies: A Scientific Statement from the American Heart Association – Circulation (free PDF)

Commentary: The Heart-Kidney, Kidney-Heart Connection and Our Improving Understanding of a Complex and Intimate Relationship – American Heart Association (free)

Top Things to Know: Cardiorenal Syndrome: Classification, Pathophysiology, Diagnosis, and Treatment Strategies – American Heart Association (free)


2 – WHO launches new global influenza strategy – World Health Organization (free)

See Report: Global influenza strategy 2019-2030 – World Health Organization (free)

Commentaries: World must prepare for inevitable next flu pandemic, WHO says – Reuters (free) AND WHO launches strategy to fight ‘inevitable’ flu pandemics – MedicalXpress (free)


3 – Signs and Symptoms That Rule out Community-Acquired Pneumonia in Outpatient Adults: A Systematic Review and Meta-Analysis – Journal of the American Board of Family Medicine (free)

Adults with an acute respiratory infection who have normal vital signs (temperature < 37,8 / respiratory rate < 20 / heart rate < 100) and a normal pulmonary examination are very unlikely to have CAP.


4 – Physical manoeuvers as a preventive intervention to manage vasovagal syncope: A systematic review – PLOS One (free)

Related: 2018 ESC Guidelines for the diagnosis and management of syncope (free) AND 2017 ACC/AHA/HRS Guideline for the Evaluation and Management of Patients With Syncope (free) AND Review: The Management of Vasovagal Syncope (free)


5 – Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults – JAMA (free for a limited period)

“This Viewpoint discusses the 2018 ACC/AHA cholesterol management guideline recommendation to consider statin treatment in adults aged >75 years with LDL levels 70-189 mg/dL, arguing that trial evidence does not support it…”


6 – Guide to Statistics and Methods: Overview of Cost-effectiveness Analysis – JAMA (free for a limited period)


7 – FDA Safety Alert: Safe Use of Surgical Staplers and Staples – Letter to Health Care Providers – U.S Food & Drug Administration (free)

Commentary: FDA Alerts Clinicians About Surgical Staple Risks – NEJM Journal Watch (free)

Related: Hidden FDA Reports Detail Harm Caused By Scores Of Medical Devices – Kaiser Health News (free)


8 – Review: Three neglected numbers in the CBC: The RDW, MPV, and NRBC count – Cleveland Clinic Journal of Medicine (free)


9 – Christopher Martyn’s research reviews, 11 March 2019 – The BMJ Opinion (free)

Christopher Martyn reviews the latest research from the top medical journals.


10 – Selective laser trabeculoplasty versus eye drops for first-line treatment of ocular hypertension and glaucoma (LiGHT): a multicentre randomised controlled trial – The Lancet (free)

Commentaries: Laser trabeculoplasty as first-line glaucoma treatment – The Lancet (free) AND 15-minute laser is best treatment for glaucoma patients, says study – The Guardian (free) AND 15-minute laser treatment best for glaucoma – OnMedica (free)


Mon, March 11 – 10 Stories of The Day!

11 Mar, 2019 | 04:16h | UTC


1 – Guidelines for Malaria Vector Control – World Health Organization (free)

See also: Cochrane Infectious Disease Group works with WHO on latest guidelines for malaria vector control – Cochrane Library (free) AND Current vector control challenges in the fight against malaria in Brazil – Revista da Sociedade Brasileira de Medicine Tropical (free)


2 – Selected Articles from the Annual Update in Intensive Care and Emergency Medicine 2019 – Critical Care (free articles)

– Sleep and Circadian Rhythm in Critical Illness

– Iron Metabolism: An Emerging Therapeutic Target in Critical Illness

– Heterogeneity in sepsis: new biological evidence with clinical applications

– Multidrug Resistant Gram-Negative Bacteria in Community-Acquired Pneumonia

– Uncovering Consciousness in Unresponsive ICU Patients: Technical, Medical and Ethical Considerations

– Mechanical Circulatory Support Devices for Cardiogenic Shock: State of the Art

– Physiological and Technical Considerations of Extracorporeal CO2 Removal

– ARDS in Obese Patients: Specificities and Management

– Recruitment Maneuvers and Higher PEEP, the So-Called Open Lung Concept, in Patients with ARDS


3 – Antiplatelet Therapy vs Anticoagulation Therapy in Cervical Artery Dissection: The Cervical Artery Dissection in Stroke Study (CADISS) Randomized Clinical Trial Final Results – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Antiplatelet and Anticoagulation Therapy May Equally Reduce Stroke Risk in Cervical Artery Dissection Patients – NeurologyToday (free) AND Stroke Prevention Agents on Par After Cervical Artery Dissection: Antiplatelet or anticoagulant treatment performed equally well in 1-year follow-up in CADISS trial – MedPage Today (free registration required)


4 – Enhanced recovery after surgery in emergency colorectal surgery: Review of literature and current practices – World Journal of Gastrointestinal Surgery (free)

Related Guidelines: Clinical Practice Guidelines for Enhanced Recovery After Colon and Rectal Surgery From the American Society of Colon and Rectal Surgeons and Society of American Gastrointestinal and Endoscopic Surgeons (free) AND Guidelines for Perioperative Care in Elective Colorectal Surgery: Enhanced Recovery After Surgery (ERAS®) Society Recommendations: 2018 (free)


5 – Man told he’s going to die by doctor on video-link robot – BBC (free)

See also: California family furious after hospital uses video call to tell grandfather he’s dying – The Guardian (free) AND Doctor on Video Screen Told a Man He Was Near Death, Leaving Relatives Aghast – The New York Times (10 articles per month are free)


6 – Overdiagnosis of pulmonary embolism: definition, causes and implications – Breathe (free)

Related: Time Trends in Pulmonary Embolism in the United States: Evidence of Overdiagnosis – JAMA Internal Medicine (free)


7 – Laboratory tests in rheumatology: A rational approach – Cleveland Clinical Journal of Medicine (free)

Source: Hospital Medicine Virtual Journal Club


8 – Diagnosing and managing diabetic somatic and autonomic neuropathy – Therapeutic Advances in Endocrinology and Metabolism (free)


9 – Impact on Cardiovascular Outcomes Among E-Cigarette Users: A Review From National Health Interview Surveys – American College of Cardiology’s 68th Annual Scientific Session (link to abstract)

Commentaries: E-cigarettes linked to heart attacks, coronary artery disease and depression – American College of Cardiology (free) AND E-cigarettes raise risk of heart attacks, strokes, depression, study says – UPI (free) AND e-Cigarettes Boost Heart Attack Risk, Emotional Stress, Findings Show – AJMC (free)


10 – Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: nationwide case-control study – The BMJ (free)

Editorial: Menopausal hormone therapy and cognition (free)

Commentaries: Systemic Hormone Therapy Tied to Small Increase in Alzheimer’s Risk – NEJM Journal Watch (free) AND ‘Small’ increase in risk of Alzheimer’s disease with HRT use, study suggests – NHS Choices (free)

“The findings of this case-control study, with the modest effect sizes and substantial potential for bias, will not change how I counsel patients regarding benefits and risks of HT.” (from Journal Watch)

“Evidence is reassuring for women needing a few years’ treatment for menopausal symptoms” (from Editorial)


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