Antiplatelet agents for preventing pre‐eclampsia and its complications – Cochrane Library (free)
Summary: Antiplatelet agents for preventing pre-eclampsia and its complications – Cochrane Library (free)
Related Randomized Trial: Aspirin versus Placebo in Pregnancies at High Risk for Preterm Preeclampsia – New England Journal of Medicine (free study and commentaries)
Summary: Does delaying cord clamping or using cord milking at birth improve the health of babies born too early? – Cochrane Library (free)
Related: Delayed umbilical cord clamping reduces hospital mortality for preterm infants (free) AND Cohort Study: Delayed Cord Clamping is Associated with Reduced Odds of Severe Neurological Injury or Mortality in Extremely Low-gestational-age Neonates (free) AND Randomized Trial: Delayed Clamping vs Milking of Umbilical Cord in Preterm Infants (link to abstract)
Related Commentary on Twitter
For babies who are born #preterm: delayed, rather than early #cordclamping, may reduce the risk of death before discharge. Updated #CochraneEvidence from @CochranePCG https://t.co/8nLKiPZvuW @CochraneNeonate
— The Cochrane Library (@CochraneLibrary) September 20, 2019
Cochrane Special Collection: Diagnosing Dementia – Cochrane Library (free articles)
Commentary: Dementia diagnosis: a decade of evidence – Evidently Cochrane (free)
Commentary: Rheumatoid arthritis: parenteral MTX tops pills for efficacy – Univadis (free registration required)
Related: The UK joint specialist societies guideline on the diagnosis and management of acute meningitis and meningococcal sepsis in immunocompetent adults (free) AND ESCMID guideline: diagnosis and treatment of acute bacterial meningitis (free) AND Meningitis (bacterial) and meningococcal septicaemia in under 16s: recognition, diagnosis and management – National Institute for Health and Care Excellence (free) AND Management of suspected viral encephalitis in adults – Association of British Neurologists and British Infection Association National Guidelines (free) AND Management of suspected viral encephalitis in children – Association of British Neurologists and British Paediatric Allergy, Immunology and Infection Group National Guidelines (free)
Summary: Bathing critically ill patients with chlorhexidine to prevent hospital-acquired infections – Cochrane Library (free)
“Due to the very low-certainty evidence available, it is not clear whether bathing with chlorhexidine reduces hospital-acquired infections, mortality, or length of stay in the ICU”
Related Guidelines: 2018 updated European League Against Rheumatism evidence-based recommendations for the diagnosis of gout – Annals of Rheumatic Disease (free) AND Management of Acute and Recurrent Gout: A Clinical Practice Guideline From the American College of Physicians (free) AND Diagnosis of Acute Gout: A Clinical Practice Guideline From the American College of Physicians (free) AND The British Society for Rheumatology Guideline for the Management of Gout – Rheumatology (free)
“TMVR was a feasible, less invasive alternative for treating severe mitral regurgitation in patients with high or prohibitive surgical risk”
Editorial: Every step you take – The BMJ (free)
Commentaries: “Sit less—move more and more often”: all physical activity is beneficial for longevity – The BMJ Opinion (free) AND ‘Sit less, move more’ may be key advice for living longer – NHS Choices (free) AND Every Little Step Helps – Any Physical Activity Linked to Decreased Mortality – MedicalResearch.com (free)
Commentaries: The Dynamics of Frailty Among Older Adults – JAMA Network Open (free) AND Frailty is a medical condition, not an inevitable result of aging – Monash University (free)
Related: Best practice guidelines for the management of frailty: a British Geriatrics Society, Age UK and Royal College of General Practitioners report – Age and Ageing (free) AND A Review of Frailty Syndrome and Its Physical, Cognitive and Emotional Domains in the Elderly – Geriatrics (free) AND Frailty: Identifying elderly patients at high risk of poor outcomes – Canadian Family Physician (free)
Screening for reducing morbidity and mortality in malignant melanoma – Cochrane Library (free)
Summary: Screening for malignant melanoma (a type of skin cancer) – Cochrane Library (free)
Featured Review: Evidence for the benefits and harms of screening for malignant melanoma – Cochrane Library (free)
Commentaries: The Evolving Paradigm of Prostate Cancer Screening – JAMA Network Open (free) AND MRIs Improve Targeting of Biopsies for Prostate Cancer Diagnosis – MedicalResearch.com (free)
Related Cochrane Review: MRI Pathway vs. Systematic Biopsy for Detecting Prostate Cancer (free)
“Prebiopsy magnetic resonance imaging combined with targeted biopsy is associated with improved detection of clinically significant prostate cancer and reduced numbers of biopsy cores per procedure, while potentially avoiding unnecessary biopsies.”
Related Guidelines: Formal guidelines: management of acute respiratory distress syndrome – Annals of Intensive Care (free) AND Guidelines on the management of acute respiratory distress syndrome – BMJ Open Respiratory Research (free) AND Guidelines On The Management Of Acute Respiratory Distress Syndrome – Intensive Care Society (free PDF) AND The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free) AND An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome (free)
Related Review: Acute Respiratory Distress Syndrome – Nature Reviews Disease Primer (free PDF)
“This network meta-analysis supports the use of prone positioning and venovenous extracorporeal membrane oxygenation in addition to lung protective ventilation in patients with ARDS.”
Lifestyle changes for treating psoriasis – Cochrane Library (free)
Related Commentary on Twitter
Lifestyle changes for treating #psoriasis – https://t.co/IqJHV5TDVE Cochrane Systematic Review includes RCTs with 1163 participants. Low‐calorie diet + exercise programme probably results in a greater reduction in the severity of psoriasis but effects vary. #skin
— The Cochrane Library (@CochraneLibrary) July 22, 2019
Meta‐analysis of effect of routine enteral nutrition on postoperative outcomes after pancreatoduodenectomy – British Journal of Surgery (link to abstract – $ for full-text)
Source: EvidenceAlerts
Related Commentary on Twitter
New @JAMANetworkOpen meta-analyses of 169 randomized trials including 302,061 participants concludes it is important to intervene early for child development in LMICs, during pregnancy if possible, & combine interventions from multiple domains https://t.co/YQnIqlz1P1 pic.twitter.com/q48D3SWhqm
— Keith Godfrey (@KeithMGodfrey) July 28, 2019
Related Meta-Analysis: Efficacy comparisons of enteral nutrition and parenteral nutrition in patients with severe acute pancreatitis: a meta-analysis from randomized controlled trials – Bioscience Reports (free) AND Enteral nutrition provided within 48 hours after admission in severe acute pancreatitis: A systematic review and meta-analysis – Medicine (free)
Related Guidelines: 2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery (free) AND American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis (free) AND Pancreatitis – National Institute for Health and Care Excellence (free) AND American College of Gastroenterology Guideline: Management of Acute Pancreatitis (free)
Safety and efficacy of testosterone for women: a systematic review and meta-analysis of randomised controlled trial data – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Testosterone may significantly improve sexual function and sexual well-being in postmenopausal women – The Lancet (free) AND Testosterone can enhance libido in postmenopausal women, new research says – CNN (free)
Related Commentary on Twitter
Just online: Safety and efficacy of #testosterone for #women: a systematic review and meta-analysis of randomised controlled trial data https://t.co/xKp6RCKd0g #postmenopausal #menopause #sexual desire pic.twitter.com/wqfMGHL37T
— The Lancet Diabetes & Endocrinology (@TheLancetEndo) July 26, 2019
Meta‐analysis of the effect of extending the interval after long‐course chemoradiotherapy before surgery in locally advanced rectal cancer – British Journal of Surgery (link to abstract – $ for full-text)
Source: EvidenceAlerts
Commentary: Review examines methods for diagnosis of elevated ICP in critically ill – MedicalXpress (free)
Related Guidelines: Management of severe traumatic brain injury (first 24 hours) – Anaesthesia Critical Care & Pain Medicine (free) AND Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury – Acta Neurochirurgica (free)
Related Reviews: Emergency Neurological Life Support: Intracranial Hypertension and Herniation – Neurocritical Care (free) AND Acute Management of Traumatic Brain Injury – Surgical Clinics of North America (free)
Related Commentary on Twitter
A question we often ask in the ED/ICU: Does this patient have increased ICP?
Our @bmj_latest study found that traditional physical exam and CT signs had poor accuracy for elevated ICP. If suspected, consider treatment & transfer for invasive monitoring.https://t.co/1Eb8PtYLFJ pic.twitter.com/bQFIgWnuur
— Shannon Fernando (@shanfernands) July 25, 2019
Commentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)
“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”
Related Commentary on Twitter
Excited to share my first study published today in @bmj_latest on recurrence risk after stopping #anticoagulation for unprovoked #VTE. Big thanks to the MARVELOUS collaborators, @CIHR_IRSC for funding/support & @RodgerMarc for continued mentorship https://t.co/jnT86dRzHK#phdlife pic.twitter.com/SSVTYwkXth
— Faizan Khan (@FaizanK91) July 25, 2019
Summary: Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Related Meta-Analysis: Choice of Intravenous Crystalloid Fluid and Mortality in Critically Ill Adult Patients – Southern Medical Journal (link to abstract – $ for full-text)
Related Randomized Trials: Balanced Crystalloids vs Saline in Hospitalized Patients (free studies and commentary)
“The three ongoing studies once published and assessed may alter the conclusions of the review.”
Editorial: Preventable harm: getting the measure right (free)
Commentaries: One in 20 patients exposed to preventable harm in medical care – OnMedica (free) AND Half of All Patient Harms ‘Preventable’ – Medscape (free registration required)
Related Commentary on Twitter
Around one in 20 patients are affected by preventable harm in medical care, of which around 12% causes permanent disability or death, finds a study published by @bmj_latest today – take a look at the research https://t.co/oHxTBlh4s1 and linked editorial https://t.co/MBW6moT3pE pic.twitter.com/gxoL4V435w
— BMJ (@bmj_company) July 18, 2019
Commentaries: Inserting informed choice into global menstrual product use and provision – The Lancet Public Health (free) AND Menstrual Cups: Study Finds They’re Safe To Use — And People Like Them – NPR (free) AND Menstrual cups ‘as reliable as tampons’ – BBC (free) AND A Better Way to Manage Your Period? Try the Menstrual Cup, Scientists Say – The New York Times (free)
Source: EvidenceAlerts
“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.
Related: Cochrane Review: Environmental Interventions to Reduce the Consumption of Sugar‐sweetened Beverages and Their Effects on Health (free study and commentaries) AND Soda Tax Linked to a 50 Percent Reduction in Sugary Drink Consumption (link to abstract and several resources on the subject) AND AAP/AHA Policy Statement: Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents (free statement and commentaries) AND Taxes on Sugar-Sweetened Beverages Associated with Reduced Consumption (link to abstract and commentaries)
Higher doses of antidepressants “not optimal”, according to new review – The Mental Elf (free)
Original Article: Meta-analysis: Optimal Dose of Antidepressants in Major Depression (free study and commentaries)
Related Commentary on Twitter
#BMJInfographic #VisualAbstract summarises new research on the effectiveness and harms of surgical interventions for stress urinary incontinence https://t.co/PWeHfzYjgA pic.twitter.com/x60OnfB9XY
— The BMJ (@bmj_latest) June 5, 2019