Oral Sex and Condom Use in a U.S. National Sample of Adolescents and Young Adults – Journal of Adolescent Health (link to abstract – $ for full-text)
Commentaries: Long-Term Safety of Glucocorticoids in Patients with Early Rheumatoid Arthritis – Journal Watch (free) AND Long-term Low-dose Steroids OK in Early RA – MedPage Today (free registration required)
“Long-Term Safety of Glucocorticoids in Early Rheumatoid Arthritis. Stopping steroids completely is difficult in patients whose disease flares with tapering, but low-dose levels are relatively safe” (RT @JWatch see Tweet)
Editorial: No benefit of arthroscopy in subacromial shoulder pain (free)
Commentaries: Common shoulder surgery may offer little pain relief – OnMedica (free) AND Is a common shoulder surgery useless? – MedicalXpress (free) AND Popular Surgery To Ease Chronic Shoulder Pain Called Into Question – NPR (free)
Exercise for the Prevention of Low Back Pain: Systematic Review and Meta-Analysis of Controlled Trials – American Journal of Epidemiology (link to abstract – $ for full-text)
Commentary: Exercise may help prevent low back pain or make it less severe – Reuters (free)
Related meta-analysis: Prevention of Low Back Pain: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free)
Commentary: New USPSTF Draft Recommendations for Osteoporosis Screening – Medscape (free registration required)
Association of trauma and posttraumatic stress disorder with incident systemic lupus erythematosus (SLE) in a longitudinal cohort of women – Arthritis & Rheumatology (link to abstract – $ for full-text)
Commentaries: A Stress Link to Lupus – The New York Times (10 articles per month are free) AND PTSD linked with increased lupus risk – Willey, via EurekAlert (free) AND Lupus risk almost three times higher after trauma – Medical News Today (free)
Corticosteroids and NSAIDs did not have different effects on pain scores, but there was a higher risk of indigestion, nausea and vomiting with NSAIDs.
Top Ten Things to Know: Management of Cardiac Involvement Associated With Neuromuscular Diseases (free PDF)
Commentary: Statement on the Management of Cardiac Involvement Associated With Neuromuscular Diseases – Practice Update (free registration required)
Effect of vitamin D supplementation in chronic widespread pain: a systematic review and meta-analysis – Clinical Rheumatology (link to abstract – $ for full-text)
Commentary: Vitamin D Supplementation Reduces Pain Scores in Chronic Widespread Pain – Practice Update (free registration required)
Mortality in idiopathic inflammatory myopathy: results from a Swedish nationwide population-based cohort study – Annals of Rheumatic Diseases (link to abstract – $ for full-text)
Commentaries: Idiopathic Inflammatory Myopathy Quadruples Death Risk – MedPage Today (free registration required) AND Inflammatory Myopathy Mortality Highest in First Year – Medscape (free registration required)
Osteoarthritis of the Knee Clical Care Standard – Australian Commission on Safety and Quality in Health Care (PDF Guideline and other resources)
Source: Research Review Australia (free resource to find articles of interest)
Source: ACP Journal Wise ($)
“Epidural injections of corticosteroid plus lidocaine offered no benefits from 6 weeks to 12 months beyond that of injections of lidocaine alone”
Is Weight Loss Associated with Less Progression of Changes in Knee Articular Cartilage among Obese and Overweight Patients as Assessed with MR Imaging over 48 Months? Data from the Osteoarthritis Initiative – Radiology (free)
Commentaries: Weight Loss Can Slow Down Knee Joint Degeneration – RSNA Press Release (free) AND Osteoarthritis: Knee joint degeneration slowed with weight loss, study confirms – Medical News Today (free)
Commentaries: Benefits and harms of osteoporosis medications unclear for patients with CKD – Medical News Today (free) AND Benefits and harms of osteoporosis medications unclear for patients with CKD – 2 Minute Medicine (free)
Source: ACP Journal Club ($)
Uric acid and incident dementia over 12 years of follow-up: a population-based cohort study – Annals of Rheumatic Diseases (link to abstract – $ for full-text)
Commentaries: Elevated Uric Acid Linked to Dementia in the Elderly – MedPage Today (free registration required) AND Dementia risk may be higher in elderly patients with high serum uric acid levels – ACP Internist (free)
When Sports Injuries Lead to Arthritis in Joints – The New York Times (10 articles per month are free)
Related guideline: The Role of Athletic Trainers in Preventing and Managing Posttraumatic Osteoarthritis in Physically Active Populations: a Consensus Statement of the Athletic Trainers’ Osteoarthritis Consortium (free)
Commentaries: Gabapentinoids Seem to Offer Little Benefit, Substantial Risks in Low Back Pain – Physician’s First Watch (free) AND Evidence does not support the use of gabapentinoids for chronic low back pain – PLOS, via Science Daily (free) AND Gabapentinoids for Chronic Low Back Pain? Not So Fast – Practical Pain Management (free)
Pregabalin and gabapentin have significant risk of adverse effects without any demonstrated benefit in chronic low back pain.
Occupation and Risk of Developing Rheumatoid Arthritis: Results From a Population-Based Case-Control Study – Arthritis Care & Research (link to abstract – $ for full-text)
Commentaries: Certain occupations linked to an increased risk of rheumatoid arthritis – Willey, via EurekAlert (free) AND Occupational Exposures Increase Rheumatoid Arthritis Risk – Medscape (free registration required) AND Some jobs tied to higher risk of rheumatoid arthritis – Reuters (free)
Case-control study suggests bricklayers, concrete workers, electricians and nurses are at increased risk.
Ibuprofen versus placebo effect on acute kidney injury in ultramarathons: a randomised controlled trial – Emergency Medicine Journal (link to abstract – $ for full-text)
State of the Art Review: Advances in the diagnosis and management of neck pain – The BMJ (free)
Related guideline: Neck Pain: Revision 2017 – Clinical Practice Guidelines Linked to the International Classification of Functioning, Disability and Health from the Orthopaedic Section of the American Physical Therapy Association (free)
Commentaries: Gout Patients Run Higher Risk of Kidney Stones – MedPage Today (free registration required) AND Gout associated with elevated risk for kidney stones – MedWire News (free)
“60% increased risk of first-time nephrolithiasis versus general population, with little protection from allopurinol” (from MedPage Today)
Functional Gain and Pain Relief After Total Joint Replacement According to Obesity Status – The Journal of Bone & Joint Surgery (link to abstract – $ for full-text)
Commentaries: Joint Replacement Weight Loss Requirements Challenged – Medscape (free registration required) AND Pain relief, functional outcomes after joint replacement similar in obese and normal-weight patients – News Medical (free)
“Mainstream medicine has failed people with chronic back pain”
Trial of Tocilizumab in Giant-Cell Arteritis – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: The GiACTA Trial (free)
Commentaries: Tocilizumab improves remission rates in giant-cell arteritis: The GiACTA trial – 2 Minute Medicine (free) AND Phase 3 trial confirms superiority of tocilizumab to steroids for giant cell arteritis – Massachusetts General Hospital, via EurekAlert (free) AND Tocilizumab With Steroid Taper Superior in GCA – Medscape (free registration required)
Commentaries: Long-Term Bisphosphonate Use Degrades Cortical Bone – Medscape (free registration required) AND How Do Bisphosphonates Cause Atypical Femoral Fractures? – MedPage Today (free registration required) AND Study highlights underlying mechanisms of fractures associated with osteoporosis drug – Cornell University, via EurekAlert (free)
Subgroup analyses of the effectiveness of oral glucosamine for knee and hip osteoarthritis: a systematic review and individual patient data meta-analysis from the OA trail bank – Annals of Rheumatic Diseases (link to abstract – $ for full-text) (RT @PhysioMeScience see Tweet)
“Currently, there is no good evidence to support the use of glucosamine for hip or knee OA”
New National Guideline Clearinghouse (NGC) Summaries in Low back, Cervical and Thoracic Spine Disorders with focus on occupational health.
Original article: Effectiveness of an Internet-Delivered Exercise and Pain-Coping Skills Training Intervention for Persons With Chronic Knee Pain: A Randomized Trial – Annals of Internal Medicine (free) AND Commentaries: Online Intervention Reduces Knee Pain, Improves Mobility – Medscape (free registration required) AND The Internet may be an effective tool for treating chronic knee pain – 2 Minute Medicine (free) AND Chronic knee pain eased with the help of Skype – CNN (free text and video)
Diclofenac 150 mg/day is the most effective NSAID available at present (are the cardiac and renal risks worth it?) and Paracetamol does not seem to work for this condition.
Related guideline: Low back pain and sciatica in over 16s: assessment and management – NICE (free)
Related Report and Consensus Statement: Sports Specialization and Intensive Training in Young Athletes – American Academy of Pediatrics (free) AND Overuse injuries and burnout in youth sports: a position statement from the American Medical Society for Sports Medicine (free)
“…cyclobenzaprine is a long-acting sedative, not a muscle relaxant, and questioning whether any potential benefits are worth the side effects”. (from TI Newsletter). “If prescribed, a dose of 5 mg at bedtime should be tried first. Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week”.
Treating axial spondyloarthritis and peripheral spondyloarthritis, especially psoriatic arthritis, to target: 2017 update of recommendations by an international task force – Annals of Rheumatic Diseases (free)
Commentary: International Guidelines Say Use Treat-to-Target for SpA, PsA – Medscape (free registration required)
Clinical Review: Optimal diagnosis and disease activity monitoring of intestinal Behçet’s disease (free)
Clinical Review: Treatment and outcomes: medical and surgical treatment for intestinal Behçet’s disease (free)
Commentary: Prompt Evaluation of Lung Bleeds Needed in Lupus – MedPage Today (free registration required)
“Low hemoglobin, low C4 and hypoxia are features of poor outcome” (from MedPage Today)
Association Between Alendronate Use and Hip Fracture Risk in Older Patients Using Oral Prednisolone – JAMA (link to abstract – $ for full-text)
Commentaries: Alendronate Cuts Hip-Fracture Rates in High-Risk Elderly – Medscape (free registration required) AND Alendronate helps cut hip fracture risk with prednisolone – OnMedica (free) AND Alendronate Might Help Protect Against Hip Fracture in Patients Taking Prednisolone – Physician’s First Watch (free)
Retrospective cohort suggests alendronate might reduce fracture risk in the short term in elderly patients taking prednisolone.
Type 2 diabetes and osteoporosis: a guide to optimal management – Journal of Clinical Endocrinology & Metabolism (link to abstract – $ for full-text)
Commentaries: Specific diabetes medications to protect bone health recommended – Endocrine Society, via ScienceDaily (free) AND Advice for Optimal Management of Diabetes and Osteoporosis – Medscape (free registration required)
Concordance of autoimmune disease in a nationwide danish systemic lupus erythematosus twin cohort – Seminars in Arthritis and Rheumatism (link to abstract – $ for full-text)
Commentary: SLE Concordance in Twins Lower than Previously Reported – MedPage Today (free registration required)
What I Wish I’d Known About My Knees – The New York Times (10 articles per month are free)
Prevalence of Axial Spondyloarthritis Among Patients With Fibromyalgia: A Magnetic Resonance Imaging Study With Application of the Assessment of SpondyloArthritis International Society Classification Criteria – Arthritis Care & Research (link to abstract – $ for full-text)
Commentary: Does Fibromyalgia Mask Spondyloarthritis? – MedPage Today (free registration required)
Small study (99 patients) showed some patients diagnosed with fibromyalgia have imaging changes suggestive of axial Spondyloarthritis, suggesting that Fibromyalgia may mask an underlying Spondyloarthropathy.
News release and available resources: CKD-Mineral and Bone Disorder (CKD-MBD) (free)
Invited commentary: Guided graded exercise self-help as a treatment of fatigue in chronic fatigue syndrome (free)
Commentary: Self-help graded exercise programme may curb CFS fatigue – OnMedica (free)
Yoga, Physical Therapy, or Education for Chronic Low Back Pain: A Randomized Noninferiority Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Yoga Vs. Physical Therapy For Chronic Low Back Pain: Which Is More Effective? – Forbes (free) AND Yoga Noninferior to Physical Therapy for Low Back Pain – Physician’s First Watch (free) AND Yoga as Good for Low Back Pain as Physical Therapy – Medscape (free registration required)
Related: Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)
“Screening for vitamin D has exploded — with no good evidence that it helps people.”
2017 American College of Rheumatology/American Association of Hip and Knee Surgeons Guideline for the Perioperative Management of Antirheumatic Medication in Patients With Rheumatic Diseases Undergoing Elective Total Hip or Total Knee Arthroplasty (free)
Press release: New Guideline Aims to Reduce Infections in Total Hip & Knee Replacement Patients (free)
Commentaries: New medication guidelines for rheumatic disease patients having joint replacement – Hospital for Special Surgery, via EurekAlert (free) AND New Guidelines Issued on Antirheumatic Drugs for Patients Undergoing Knee or Hip Replacement – Physician’s First Watch (free)
EULAR recommendations for women’s health and the management of family planning, assisted reproduction, pregnancy and menopause in patients with systemic lupus erythematosus and/or antiphospholipid syndrome (free)
Commentary: EULAR: Guidance for Managing Lupus Pregnancy – MedPage Today (free registration required)
Observational studies suggest that high serum uric acid levels are associated with multiple health outcomes, including cardiovascular and metabolic diseases. This review findings suggest there is a clear association only for gout and nephrolithiasis.
Commentaries: RA, Methotrexate and Alcohol May Mix Well, to a Degree – Rheumatology Network (free) AND Moderate Alcohol Use Could Be Safe With Methotrexate for RA – Medscape (free registration required)
See also: DASH Diet May Reduce Gout Risk – Medscape (free registration required)
Triple Therapy Versus Biologic Therapy for Active Rheumatoid Arthritis: A Cost-Effectiveness Analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: In Rheumatoid Arthritis, Adding a Biologic Agent Before Trying Triple Therapy Likely Not Cost-Effective – Physician’s First Watch(free) AND Biologics before triple therapy not cost effective for rheumatoid arthritis – MedicalXpress (free) Triple Therapy More Cost-Effective Than MTX + Biologic in RA – Medscape (free registration required)
Author interview video: Comparison of Intra-articular Triamcinolone vs Saline for Knee Osteoarthritis (free)
JAMA report video: Comparison of Intra-articular Triamcinolone vs Saline for Knee Osteoarthritis (free)
Switching from originator infliximab to biosimilar CT-P13 compared with maintained treatment with originator infliximab (NOR-SWITCH): a 52-week, randomised, double-blind, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentaries: This orthopedic surgery is the world’s most common. But patients rarely benefit, a panel says – STAT News (free) AND Guideline Recommends Against Arthroscopy for Most Cases of Degenerative Knee Disease – Journal Watch (free) AND Arthroscopic Surgery Doesn’t Help With Arthritis Knee Pain – NPR Health News (free)
Commentaries: ACP Updates Guidelines on Treating Low Bone Density, Osteoporosis – Physician’s First Watch (free) AND New ACP Guidelines on the Treatment of Osteoporosis – Medscape (free registration required)
Related guideline: UK clinical guideline for the prevention and treatment of osteoporosis – Archives of Osteoporosis (free)
After Knee or Hip Replacement, No Place Like Home – The New York Times (10 articles per month are free)
Original article abstract ($ for full-text): Effect of Inpatient Rehabilitation vs a Monitored Home-Based Program on Mobility in Patients With Total Knee Arthroplasty: The HIHO Randomized Clinical Trial – JAMA (free)
The NYT commentary talks about the futility of some interventions currently used to postpone surgery and about the benefits of outpatient rehabilitation.
Selection of resources for primary care providers to improve their ability to prevent and treat injuries from sports and physical activity.
Source: EULAR Revised Recommendations for the Management of Fibromyalgia – Medscape (free registration required)
Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)
“Labs performing these tests are reporting perfectly normal levels of vitamin D — 20 to 30 nanograms per milliliter of blood — as “insufficient.” As a consequence, millions of healthy people think they have a deficiency”
Note: Some organizations still think appropriate levels would be above 30 nanograms per milliliter of blood, more details in the text.
The wound/burn guidelines – Japanese Dermatological Association (all guidelines are free)
Wounds in general / Guidelines for the diagnosis and treatment for pressure ulcers / Guidelines for the diagnosis and treatment for diabetic ulcer/gangrene / Guidelines for the management of skin ulcers associated with connective tissue disease/vasculitis / Guidelines for the management of lower leg ulcers/varicose veins / Guidelines for the management of burns
Browse Appropriateness Criteria Topics (free)
This comprehensive guide from American College of Radiology (ACR) covers 230 topics with more than 1,100 clinical indications and has just been updated. It is a very useful resource for doctors in all specialties to guide which exam is most appropriate in each clinical situation.
Total knee replacement for patients with osteoarthritis had minimal effects on quality of life in this study. Severely affected patients seem to benefit the most from the procedure.
See also: EULAR Releases New RA Tx Recommendations: Focus is on conventional agents, biologics, and targeted synthetic drugs – MedPage Today(free registration required)
Source: EvidenceAlerts Newsletter
Comprehensive review with practical algorithm.