Systematic Reviews & Meta-analysis
M-A: Airway ultrasound as predictor of difficult direct laryngoscopy.
21 Mar, 2022 | 08:36h | UTC
Systematic Review: Strategies for using topical corticosteroids in children and adults with eczema.
21 Mar, 2022 | 08:33h | UTCStrategies for using topical corticosteroids in children and adults with eczema – Cochrane Library
Summary: What is the best way to use topical corticosteroids to treat people with eczema? – Cochrane Library
Commentary on Twitter
What is the best way to use topical #corticosteroids to treat people with #eczema?
"Generally, stronger topical corticosteroids are probably more effective than weaker preparations". https://t.co/iaH6fzyXL4Read the latest evidence from @CochraneSkin @CebdNottm pic.twitter.com/f01BO2FyDs
— Cochrane UK (@CochraneUK) March 17, 2022
M-A: Duration of postpartum magnesium sulphate for the prevention of eclampsia.
18 Mar, 2022 | 07:38h | UTC
Systematic Review: Behavioral approaches to recruitment and retention in clinical trials.
18 Mar, 2022 | 07:40h | UTCRelated:
Perspective: How Can We Keep Participants in Clinical Trials Involved
Treatments for moderate to severe COVID-19: Cochrane evidence.
17 Mar, 2022 | 09:19h | UTCTreatments for moderate to severe COVID-19: Cochrane evidence – Evidently Cochrane
Treatments for mild COVID-19: Cochrane evidence.
17 Mar, 2022 | 09:17h | UTCTreatments for mild COVID-19: Cochrane evidence – Cochrane Library
At-a-glance PICO summaries are now available with Cochrane Abstracts.
17 Mar, 2022 | 08:36h | UTC
Commentary on Twitter
New @CochraneLibrary feature! #PICO terms will now display on Cochrane review pages, helping you to find the most relevant Cochrane evidence to answer your research or clinical question! https://t.co/KkRaXJXpCc pic.twitter.com/LHCPgyPiE6
— The Cochrane Library (@CochraneLibrary) March 16, 2022
M-A: The role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS.
17 Mar, 2022 | 08:31h | UTCThe role of acute hypercapnia on mortality and short-term physiology in patients mechanically ventilated for ARDS: a systematic review and meta-analysis – Intensive Care Medicine (free for a limited period)
Commentary on Twitter
Acute hypercapnia in #ARDS pts on MV, SR/MA.
Conflicting effect! Protective effects of permissive hypercapnia seem driven by associated PV (improved hemodynamics) vs deleterious effects of imposed hypercapnia seem mediated by pulmonary vascular dysfunctionhttps://t.co/H1TuliectW pic.twitter.com/uLoAZPvbWg— Intensive Care Medicine (@yourICM) March 16, 2022
Systematic Review: Perioperative enhanced recovery programs for women with gynecological cancers.
16 Mar, 2022 | 10:05h | UTCPerioperative enhanced recovery programmes for women with gynaecological cancers – Cochrane Library
See also: Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines (some guidelines are free)
M-A: Association of low- and no-calorie sweetened beverages as a replacement for sugar-sweetened beverages with body weight and cardiometabolic risk.
16 Mar, 2022 | 09:49h | UTCCommentary: Alternative sweeteners in your drinks can help with weight and diabetes risk, study says – CNN
Commentary on Twitter
Meta-analysis of 17 trials found low-calorie sweetened beverages were associated with improvement in body weight and metabolic risk, suggesting they may be a viable alternative to water when replacing sugar-sweetened beverages in overweight & obese adults. https://t.co/coz3U4pIZA
— JAMA Network Open (@JAMANetworkOpen) March 14, 2022
M-A: Intraoperative redosing of surgical antibiotic prophylaxis in addition to preoperative prophylaxis vs. single-dose prophylaxis for the prevention of surgical site infection.
16 Mar, 2022 | 08:34h | UTC
M-A: Survival after neoadjuvant therapy with trastuzumab–lapatinib and chemotherapy in patients with HER2-positive early breast cancer.
16 Mar, 2022 | 08:30h | UTC
M-A: Evaluating the association between LDL Cholesterol reduction and relative and absolute effects of statin treatment.
15 Mar, 2022 | 10:04h | UTCEvaluating the Association Between Low-Density Lipoprotein Cholesterol Reduction and Relative and Absolute Effects of Statin Treatment: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Commentary from the author: Benefits of statins may have been overstated – new study – The Conversation
Commentary on Twitter
Our study in @JAMAInternalMed asked 2 questions 1. Is reducing one’s ‘bad’ cholesterol was associated with a proportional reduction in death, heart attack and stroke? 2. What's the absolute reduction in risk from taking statins? https://t.co/Zwh7LmUD0e
— Dr Paula Byrne (@pbyrne82) March 14, 2022
M-A: Reassessment of the efficacy of carboplatin for metastatic urothelial carcinoma in the era of immunotherapy.
15 Mar, 2022 | 08:05h | UTC
Systematic review and non-inferiority meta-analysis of randomized phase II/III trials on S-1-based therapy vs. 5-fluorouracil- or capecitabine-based therapy in the treatment of patients with metastatic colorectal cancer.
15 Mar, 2022 | 08:06h | UTC
Meta-analysis of randomized controlled trials comparing intraoperative red blood cell transfusion strategies.
14 Mar, 2022 | 01:47h | UTCRelated:
Research: Restrictive or Liberal Red-Cell Transfusion for Cardiac Surgery
Transfusion Requirements After Cardiac Surgery: The TRACS Randomized Controlled Trial – JAMA
Systematic Review: Inhaled corticosteroids for the treatment of COVID‐19.
11 Mar, 2022 | 10:18h | UTCInhaled corticosteroids for the treatment of COVID‐19 – Cochrane Library
Related:
[Preprint] M-A: Inhaled corticosteroids in COVID-19 outpatients.
Position Paper: Recommendations for the use of topical inhalant budesonide in COVID-19.
RCT: Inhaled budesonide shortens recovery time in non-hospitalized patients with COVID-19
Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
Commentary on Twitter (thread – click for more)
Are inhaled #corticosteroids an effective treatment for people with mild #COVID19?
New #systematicreview from @CochraneAirways looks at using this well established treatment for asthma & COPD as a #COVIDtreatment https://t.co/dxUtudHLiW 1/4 pic.twitter.com/4nUs56Xfsg— The Cochrane Library (@CochraneLibrary) March 9, 2022
Optimizing hospital electronic prescribing systems: a systematic scoping review.
11 Mar, 2022 | 10:02h | UTC
Efficacy and safety of non-operative management of uncomplicated acute appendicitis compared to appendectomy: an umbrella review of systematic reviews and meta-analyses.
11 Mar, 2022 | 09:49h | UTCRelated:
Review: Diagnosis of uncomplicated and complicated appendicitis in adults.
A Randomized trial comparing antibiotics with appendectomy for appendicitis
Systematic Review: Antiplatelet agents for chronic kidney disease.
11 Mar, 2022 | 09:35h | UTCAntiplatelet agents for chronic kidney disease – Cochrane Library
Study Commentary: Telemental health is promising as an effective and engaging alternative for in-person therapy.
11 Mar, 2022 | 09:26h | UTCOriginal Study: Implementation of Telemental Health Services Before COVID-19: Rapid Umbrella Review of Systematic Reviews – Journal of Medical Internet Research
RCT: In patients with low-risk thyroid cancer, thyroidectomy without ablation radioiodine was noninferior to thyroidectomy with ablation radioiodine at 3 years.
10 Mar, 2022 | 10:59h | UTCThyroidectomy without Radioiodine in Patients with Low-Risk Thyroid Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: New research casts doubt on a cornerstone of thyroid cancer treatment – STAT
Commentary on Twitter
In RCT involving patients with low-risk differentiated thyroid cancer undergoing thyroidectomy, a follow-up strategy that did not involve the use of radioiodine was noninferior to the use of radioiodine in the response to treatment at 3 years. https://t.co/RaJL3tdE4T pic.twitter.com/8nIPw50nkg
— NEJM (@NEJM) March 9, 2022
Meta-analysis of randomized trials: benefits and harms of direct oral anticoagulation and low molecular weight heparin for thromboprophylaxis in patients undergoing non-cardiac surgery.
10 Mar, 2022 | 10:48h | UTC
Commentary on Twitter
Led by Maura Marcucci, network meta-analysis of of 68 surgery #RCT's (45,445 patients; mainly #ortho) found that #DOAC's & #LMWH reduce #VTE but probably increase major bleeding to a similar extent. DOACs probably prevent symptomatic VTE more than #LMWH. https://t.co/7vrgVpfD3s pic.twitter.com/H5Fuq7p1hi
— Kari Tikkinen (@KariTikkinen) March 9, 2022
M-A: Comparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia.
10 Mar, 2022 | 10:54h | UTCComparative efficacy and tolerability of 32 oral and long-acting injectable antipsychotics for the maintenance treatment of adults with schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)
Systematic Review: Pharmacotherapy for post-traumatic stress disorder.
10 Mar, 2022 | 10:30h | UTCPharmacotherapy for post traumatic stress disorder (PTSD) – Cochrane Library