Systematic Reviews & Meta-analysis
M-A | Cardiovascular safety of febuxostat and allopurinol in patients with gout.
11 Nov, 2022 | 13:41h | UTC
M-A | Head-to-head trials comparing sulfonylureas and low hypoglycemic risk antidiabetic drugs.
11 Nov, 2022 | 13:38h | UTC
M-A | The response of subgroups of patients with schizophrenia to different antipsychotic drugs.
11 Nov, 2022 | 13:13h | UTCThe response of subgroups of patients with schizophrenia to different antipsychotic drugs: a systematic review and meta-analysis – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
"Overall, these results suggest that the effectiveness and side-effect patterns of the [antipsychotic] drugs do not differ in the various subgroups of patients with schizophrenia."
New research Article @StefanLeucht https://t.co/sjcRN5nH0T
— The Lancet Psychiatry (@TheLancetPsych) October 11, 2022
M-A | Medication reviews and deprescribing as a single intervention in falls prevention.
11 Nov, 2022 | 12:53h | UTC
M-A | DOACs increase the risk of arterial thrombosis vs. Vitamin-K antagonists in antiphospholipid syndrome.
9 Nov, 2022 | 12:28h | UTCDirect Oral Anticoagulants vs Vitamin-K Antagonists in Thrombotic Antiphospholipid Syndrome: Meta-analysis of Randomized Controlled Trials – Journal of the American College of Cardiology (link to abstract – $ for full-text)
M-A | Comparative efficacy of antiplatelet or anticoagulant therapy in patients with chronic coronary syndromes after PCI.
9 Nov, 2022 | 12:20h | UTC
Defining the optimum strategy for identifying adults and children with celiac disease: systematic review and economic modeling.
9 Nov, 2022 | 12:16h | UTC
M-A | Point-of-care ultrasound evaluation for patients with acute onset dyspnea.
9 Nov, 2022 | 12:14h | UTC
SR | Efficacy and safety of stereotactic body radiotherapy for painful bone metastases.
8 Nov, 2022 | 12:00h | UTC
M-A | Efficacy and safety of pharmacological interventions for pruritus in primary biliary cholangitis.
8 Nov, 2022 | 11:58h | UTC
M-A | Outcomes of dexmedetomidine vs. propofol sedation in critically ill adults requiring mechanical ventilation.
8 Nov, 2022 | 11:52h | UTC
SR | Efficacy and safety of IL-6 inhibition with biological DMARDs in immune-mediated inflammatory diseases.
8 Nov, 2022 | 11:47h | UTC
Commentary on Twitter
Check out our latest systematic literature review on IL-6 inhibition in immune-mediated inflammatory diseases:
▶️ positive clinical in a group of diseases
▶️ benefits in #COVID-19
▶️ similar safety outcomes vs other bDMARDs? https://t.co/N1S9H2NrLQ pic.twitter.com/IAFGoEgkrY
— ARD & RMD Open (@ARD_BMJ) September 29, 2022
Updated systematic review on cannabis and other plant-based treatments for chronic pain.
7 Nov, 2022 | 12:39h | UTCRelated:
Systematic Review: Cannabis-based products for chronic pain.
Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders
M-A: Birth outcomes of neonates exposed to marijuana in utero.
Cannabis-related allergies: an international overview and consensus recommendations.
Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.
Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.
Guideline: Medical cannabis or cannabinoids for chronic pain.
NICE Guideline: Cannabis-Based Medicinal Products
Short Review: Drug Interactions with Cannabinoids
Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain
Review: Considerations for cannabinoids in perioperative care by anesthesiologists.
Review: Cannabis-based Medicines and the Perioperative Physician
Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know
M-A | Association of intraventricular fibrinolysis with clinical outcomes in intracerebral hemorrhage.
7 Nov, 2022 | 12:31h | UTCAssociation of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis – Stroke (free for a limited period)
Commentary on Twitter
#STROKE #IntraventricularFibrinolysis is associated with better functional outcomes and reduced mortality in #ICH patients with #IVH, with treatment effect linked to an early time window <48h #MetaAnalysis https://t.co/hRQJ9w5ppv @WendyZiai @GuidoFalconeMD @sheth_kevin pic.twitter.com/INeDIIHCBw
— Stroke AHA/ASA (@StrokeAHA_ASA) September 30, 2022
M-A | Migraine is linked to an increased risk of anxiety and depressive symptoms in children and adolescents.
4 Nov, 2022 | 13:20h | UTCAnxiety and Depressive Symptoms and Disorders in Children and Adolescents With Migraine: A Systematic Review and Meta-analysis – JAMA Pediatrics (Free for a limited period)
Editorial: Migraine and Mental Health in Pediatrics – Pediatrics (free for a limited period)
Commentary: Youth With Migraines Twice as Likely to Have Anxiety, Depression – Psychiatric News Alert
M-A | Postoperative analgesia efficacy of erector spinae plane block in adult abdominal surgery.
3 Nov, 2022 | 13:59h | UTC
SR | Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults.
3 Nov, 2022 | 13:40h | UTCSummary: Treatment of inflammatory conditions of the eye with medications – Cochrane Library
M-A | Perioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy.
2 Nov, 2022 | 14:22h | UTCPerioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy: meta-analysis – British Journal of Surgery (link to abstract – $ for full-text)
Commentary on Twitter
Perioperative interventions to reduce POPF ? following pancreatoduodenectomy @BJSurgery
? Meta analysis reveal RCTs small and underpowered
Possible role for the following:
⛽️ External pancreatic duct drainage
? Ulinastatin
? Invagination techniquehttps://t.co/IqPMLjb1Er pic.twitter.com/wv6RQUE3lY— Giovanni Marchegiani (@Gio_Marchegiani) June 29, 2022
M-A | Association of SGLT2 inhibitors with cardiovascular outcomes and safety events.
1 Nov, 2022 | 11:56h | UTC
M-A | Efficacy of preventive use of oxygen therapy after planned extubation in high-risk patients with extubation failure.
1 Nov, 2022 | 11:55h | UTC
Perioperative mortality in pediatric patients: a systematic review of risk assessment tools for use in the preoperative setting.
31 Oct, 2022 | 13:57h | UTC
Commentary on Twitter
In a new systemic review of preexisting literature on the prediction of #mortality in #pediatric populations, all chosen models exhibited good performance. However, many had high or unclear risks of bias, and most had not been externally validated. https://t.co/dfw95xgd4y pic.twitter.com/9GxCzrsAD2
— Anesthesiology (@_Anesthesiology) October 21, 2022
SR | Immediate versus delayed postpartum insertion of contraceptive implant and IUD for contraception.
31 Oct, 2022 | 13:56h | UTC
M-A | Comparison of continuous versus intermittent enteral feeding in critically ill patients.
31 Oct, 2022 | 13:48h | UTC
M-A of RCT | Combination of ulinastatin and somatostatin evaluated in acute pancreatitis.
31 Oct, 2022 | 13:44h | UTC
M-A | Selective decontamination of the GI tract may reduce in-hospital mortality in ICU patients receiving mechanical ventilation.
27 Oct, 2022 | 12:39h | UTCAssociation Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis – JAMA (free for a limited period)
Related Study: Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA (free for a limited period)