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Systematic Reviews & Meta-analysis

M-A | Cardiovascular safety of febuxostat and allopurinol in patients with gout.

11 Nov, 2022 | 13:41h | UTC

Cardiovascular safety of febuxostat and allopurinol in patients with gout: A meta-analysis – Frontiers in Pharmacology

 


M-A | Head-to-head trials comparing sulfonylureas and low hypoglycemic risk antidiabetic drugs.

11 Nov, 2022 | 13:38h | UTC

Systematic review and meta-analysis of head-to-head trials comparing sulfonylureas and low hypoglycaemic risk antidiabetic drugs – BMC Endocrine Disorders

 


M-A | The response of subgroups of patients with schizophrenia to different antipsychotic drugs.

11 Nov, 2022 | 13:13h | UTC

The response of subgroups of patients with schizophrenia to different antipsychotic drugs: a systematic review and meta-analysis – The Lancet Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter (thread – click for more)

 


M-A | Medication reviews and deprescribing as a single intervention in falls prevention.

11 Nov, 2022 | 12:53h | UTC

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

 


M-A | DOACs increase the risk of arterial thrombosis vs. Vitamin-K antagonists in antiphospholipid syndrome.

9 Nov, 2022 | 12:28h | UTC

Direct Oral Anticoagulants vs Vitamin-K Antagonists in Thrombotic Antiphospholipid Syndrome: Meta-analysis of Randomized Controlled Trials – Journal of the American College of Cardiology (link to abstract – $ for full-text)

 


M-A | Comparative efficacy of antiplatelet or anticoagulant therapy in patients with chronic coronary syndromes after PCI.

9 Nov, 2022 | 12:20h | UTC

Comparative efficacy and safety of antiplatelet or anticoagulant therapy in patients with chronic coronary syndromes after percutaneous coronary intervention: A network meta-analysis of randomized controlled trials – Frontiers in Pharmacology

 


Defining the optimum strategy for identifying adults and children with celiac disease: systematic review and economic modeling.

9 Nov, 2022 | 12:16h | UTC

Defining the optimum strategy for identifying adults and children with coeliac disease: systematic review and economic modelling – Health Technology Assessment

 


M-A | Point-of-care ultrasound evaluation for patients with acute onset dyspnea.

9 Nov, 2022 | 12:14h | UTC

Point-of-care ultrasound improves clinical outcomes in patients with acute onset dyspnea: a systematic review and meta-analysis – Internal and Emergency Medicine

 


SR | Efficacy and safety of stereotactic body radiotherapy for painful bone metastases.

8 Nov, 2022 | 12:00h | UTC

Efficacy and safety of stereotactic body radiotherapy for painful bone metastases: Evidence from randomized controlled trials – Frontiers in Oncology

 


M-A | Efficacy and safety of pharmacological interventions for pruritus in primary biliary cholangitis.

8 Nov, 2022 | 11:58h | UTC

Efficacy and safety of pharmacological interventions for pruritus in primary biliary cholangitis: A systematic review and meta-analysis – Frontiers in Pharmacology

 


M-A | Outcomes of dexmedetomidine vs. propofol sedation in critically ill adults requiring mechanical ventilation.

8 Nov, 2022 | 11:52h | UTC

Outcomes of dexmedetomidine versus propofol sedation in critically ill adults requiring mechanical ventilation: a systematic review and meta-analysis of randomised controlled trials – British Journal of Anaesthesia

 


SR | Efficacy and safety of IL-6 inhibition with biological DMARDs in immune-mediated inflammatory diseases.

8 Nov, 2022 | 11:47h | UTC

A systematic literature review informing the consensus statement on efficacy and safety of pharmacological treatment with interleukin-6 pathway inhibition with biological DMARDs in immune-mediated inflammatory diseases – RMD Open

 

Commentary on Twitter

 


Updated systematic review on cannabis and other plant-based treatments for chronic pain.

7 Nov, 2022 | 12:39h | UTC

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Related:

Systematic Review: Cannabis-based products for chronic pain.

Podcast: #338 LIVE! Medical Cannabis: Is it still dope? – The Curbsiders

Medicinal Cannabis for Chronic Pain: The Bermuda Triangle of Low Quality Studies, Countless Meta-analyses and Conflicting Recommendations – European Journal of Pain

RCT: Effect of medical marijuana card ownership on pain, insomnia, and affective disorder symptoms in adults. 

Cohort Study: Long-term cannabis use is associated with cognitive deficits and smaller hippocampal volume in midlife. 

AHA Scientific Statement | How does cannabis use affect brain health? Caution advised, more research needed.

M-A: Birth outcomes of neonates exposed to marijuana in utero. 

Cannabis-related allergies: an international overview and consensus recommendations.

Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

Review: Considerations for cannabinoids in perioperative care by anesthesiologists.

Review: Cannabis-based Medicines and the Perioperative Physician

Study: Cannabis Use Disorder May Increase the Risk of Cardiovascular Events in Major Elective Surgeries

Perspective: If You Smoke Pot, Your Anesthesiologist Needs To Know

Perioperative Care of Cannabis Users: A Comprehensive Review of Pharmacological and Anesthetic Considerations

 


M-A | Association of intraventricular fibrinolysis with clinical outcomes in intracerebral hemorrhage.

7 Nov, 2022 | 12:31h | UTC

Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis – Stroke (free for a limited period)

Commentary: Article Commentary: “Association of Intraventricular Fibrinolysis With Clinical Outcomes in ICH” – Blogging Stroke

 

Commentary on Twitter

 


M-A | Migraine is linked to an increased risk of anxiety and depressive symptoms in children and adolescents.

4 Nov, 2022 | 13:20h | UTC

Anxiety and Depressive Symptoms and Disorders in Children and Adolescents With Migraine: A Systematic Review and Meta-analysis – JAMA Pediatrics (Free for a limited period)

Editorial: Migraine and Mental Health in Pediatrics – Pediatrics (free for a limited period)

Commentary: Youth With Migraines Twice as Likely to Have Anxiety, Depression – Psychiatric News Alert

 


M-A | Postoperative analgesia efficacy of erector spinae plane block in adult abdominal surgery.

3 Nov, 2022 | 13:59h | UTC

Postoperative analgesia efficacy of erector spinae plane block in adult abdominal surgery: A systematic review and meta-analysis of randomized trials – Frontiers in Medicine 

 


SR | Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults.

3 Nov, 2022 | 13:40h | UTC

Non‐biologic, steroid‐sparing therapies for non‐infectious intermediate, posterior, and panuveitis in adults – Cochrane Library

Summary: Treatment of inflammatory conditions of the eye with medications – Cochrane Library

 


M-A | Perioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy.

2 Nov, 2022 | 14:22h | UTC

Perioperative interventions to reduce pancreatic fistula following pancreatoduodenectomy: meta-analysis – British Journal of Surgery (link to abstract – $ for full-text)

 

Commentary on Twitter

 


M-A | Association of SGLT2 inhibitors with cardiovascular outcomes and safety events.

1 Nov, 2022 | 11:56h | UTC

Association of sodium-glucose cotransporter 2 inhibitors with cardiovascular outcome and safety events: A meta-analysis of randomized controlled clinical trials – Frontiers in Cardiovascular Medicine

 


M-A | Efficacy of preventive use of oxygen therapy after planned extubation in high-risk patients with extubation failure.

1 Nov, 2022 | 11:55h | UTC

Efficacy of preventive use of oxygen therapy after planned extubation in high-risk patients with extubation failure: A network meta-analysis of randomized controlled trials – Frontiers in Medicine

 


Perioperative mortality in pediatric patients: a systematic review of risk assessment tools for use in the preoperative setting.

31 Oct, 2022 | 13:57h | UTC

Perioperative Mortality in Pediatric Patients: A Systematic Review of Risk Assessment Tools for Use in the Preoperative Setting – Anesthesiology

 

Commentary on Twitter

 


SR | Immediate versus delayed postpartum insertion of contraceptive implant and IUD for contraception.

31 Oct, 2022 | 13:56h | UTC

Immediate versus delayed postpartum insertion of contraceptive implant and IUD for contraception – Cochrane Library

Summary: Is it better to insert an implant or intrauterine device (coil) for contraception within days of childbirth or wait 4 to 6 weeks? – Cochrane Library

 


M-A | Comparison of continuous versus intermittent enteral feeding in critically ill patients.

31 Oct, 2022 | 13:48h | UTC

Comparison of continuous versus intermittent enteral feeding in critically ill patients: a systematic review and meta-analysis – Critical Care

 


M-A of RCT | Combination of ulinastatin and somatostatin evaluated in acute pancreatitis.

31 Oct, 2022 | 13:44h | UTC

The combination of ulinastatin and somatostatin reduces complication rates in acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials – Scientific Reports

 


M-A | Selective decontamination of the GI tract may reduce in-hospital mortality in ICU patients receiving mechanical ventilation.

27 Oct, 2022 | 12:39h | UTC

Association Between Selective Decontamination of the Digestive Tract and In-Hospital Mortality in Intensive Care Unit Patients Receiving Mechanical Ventilation: A Systematic Review and Meta-analysis – JAMA (free for a limited period)

Related Study: Effect of Selective Decontamination of the Digestive Tract on Hospital Mortality in Critically Ill Patients Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA (free for a limited period)

 


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