Systematic Reviews

Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis – The BMJ (free)

Editorial: Preventable harm: getting the measure right (free)

Commentaries: One in 20 patients exposed to preventable harm in medical care – OnMedica (free) AND Half of All Patient Harms ‘Preventable’ – Medscape (free registration required)

 

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Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis – Stroke (free)

Source: EvidenceAlerts

“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.

 


Surgical interventions for women with stress urinary incontinence: systematic review and network meta-analysis of randomised controlled trials – The BMJ (free)

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Preventive lipid‐based nutrient supplements given with complementary foods to infants and young children 6 to 23 months of age for health, nutrition, and developmental outcomes – Cochrane Library (free)

Summary: Effect of lipid-based nutrient supplementation on infants and young children – Cochrane Library (free)

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Positional therapy for obstructive sleep apnoea – Cochrane Library (free)

Summary: Are interventions to keep people sleeping on their side the best way to treat obstructive sleep apnoea? – Cochrane Library (free)

 

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Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis – PLOS Medicine (free)

Source: EvidenceAlerts

“Our findings suggest that to provide clinical benefit with the least effect on growth, the number of repeat treatment courses should be limited to a maximum of three and the total dose to between 24 mg and 48 mg.”

 


Schedules for Self-monitoring Blood Pressure: A Systematic Review – American Journal of Hypertension (free)

Home blood pressure should be measured for 3 days, increased to 7 only when mean blood pressure is close to a diagnostic or treatment threshold.”

 


Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis – Blood Advances (free)

Our findings indicate that patients on VKA therapy who have an INR between 4.5 and 10.0 without bleeding are not likely to benefit from vitamin K administration in addition to temporary VKA cessation.”

 


Mode of delivery and preterm birth in subsequent births: A systematic review and meta-analysis – PLOS One (free)

“A previous cesarean section could increase the risk of preterm birth in subsequent pregnancies”

 


Epidural analgesia for adults undergoing cardiac surgery with or without cardiopulmonary bypass – Cochrane Library (free)

Summary: Epidural analgesia for heart surgery with or without the heart lung machine in adults – Cochrane Library (free)

“Compared with systemic analgesia, epidural analgesia may reduce the risk of myocardial infarction, respiratory depression, and atrial fibrillation / atrial flutter, as well as the duration of tracheal intubation and pain, in adults undergoing cardiac surgery.”

 


Paracetamol versus placebo for knee and hip osteoarthritis – Cochrane Library (free)

Summary: Paracetamol for treating people with hip or knee osteoarthritis – Cochrane Library (free)

Related: Paracetamol: widely used and largely ineffective (free)

 

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Subacromial decompression surgery for rotator cuff disease – Cochrane Library (free)

Summary: Surgery for rotator cuff disease (free)

Related Studies: Subacromial Decompression vs Diagnostic Arthroscopy for Shoulder Impingement (free study and commentaries) AND Arthroscopic subacromial decompression for subacromial shoulder pain (free study and commentaries)

“The data in this review do not support the use of subacromial decompression in the treatment of rotator cuff disease manifest as painful shoulder impingement.”

 


Short‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2 diabetes mellitus – Cochrane Library (free)

Summary: Short-acting insulin analogues versus regular human insulin for type 2 diabetes mellitus – Cochrane Library (free)

“The current evidence from clinical trials suggests neither clear benefits nor clear harms from the use of short‐acting insulin analogues over regular human insulin.”

 


Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life – Cochrane Library (free)

Summary: Vitamin and mineral supplementation for preventing cognitive deterioration in cognitively healthy people in mid and late life – Cochrane Library (free)

Commentary: Preventing dementia: do vitamin and mineral supplements have a role? – Evidently Cochrane (free)

 

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Proton pump inhibitors and risk of hip fracture: a meta-analysis of observational studies – Osteoporosis International (link to abstract – $ for full-text)

Commentary: PPIs up risk for hip fracture in large meta-analysis – Univadis (free registration required)

 

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Ezetimibe for the prevention of cardiovascular disease and all‐cause mortality events – Cochrane Library (free)

Summary: Ezetimibe for the prevention of heart disease and death – Cochrane Library (free)

In individuals with established atherosclerotic cardiovascular disease, Ezetimibe has modest beneficial effects, primarily driven by a reduction in non‐fatal MI and non‐fatal stroke, but with little or no effect on clinical fatal endpoints.