Systematic Reviews

Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis – British Journal of Sports Medicine (free)

 

Related Commentary on Twitter

 


Valproate for acute mania – Cochrane Library (free)

Summary: Valproate for acute mania  – Cochrane Library (free)

 

Related Commentary on Twitter

 


Efficacy of Neurohormonal Therapies in Preventing Cardiotoxicity in Patients With Cancer Undergoing Chemotherapy – JACC CardioOncology (free)

 

Related Commentary on Twitter

 


Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Meta-Analysis of TAVR vs. SAVR in Low-Risk Patients – American College of Cardiology (free) AND TAVR Survival Surpasses SAVR in Low-Risk Patients: Meta-analysis – Medscape (free registration required)

“The one clear unknown that everyone points to is valve durability” (form Medscape)

“longer follow-up regarding valve degeneration will be needed to confirm TAVR as the preferred treatment for low-risk patients with severe AS.” (from American College of Cardiology)

 


Antiviral treatment for Bell’s palsy (idiopathic facial paralysis) – Cochrane Library (free)

Summary: Antiviral treatment for Bell’s palsy – Cochrane Library (free)

“The combination of antivirals and corticosteroids may have little or no effect on rates of incomplete recovery in comparison to corticosteroids alone”

 


Altering the availability or proximity of food, alcohol, and tobacco products to change their selection and consumption – Cochrane Library (free)

Summary: Altering the availability or proximity of food, alcohol, and tobacco products to change their selection and consumption – Cochrane Library (free)

 

Related Commentary on Twitter

 


Chlorhexidine bathing of the critically ill for the prevention of hospital‐acquired infection – Cochrane Library (free)

Summary: Bathing critically ill patients with chlorhexidine to prevent hospital-acquired infections – Cochrane Library (free)

“Due to the very low-certainty evidence available, it is not clear whether bathing with chlorhexidine reduces hospital-acquired infections, mortality, or length of stay in the ICU”

 


Early Experience With Transcatheter Mitral Valve Replacement: A Systematic Review – Journal of the American Heart Association (free)

“TMVR was a feasible, less invasive alternative for treating severe mitral regurgitation in patients with high or prohibitive surgical risk”

 


Effects of maternal influenza vaccination on adverse birth outcomes: A systematic review and Bayesian meta-analysis – PLOS One (free)

Related Research: Cohort Study: Flu Vaccine in Pregnancy Safe for Children and Mothers (free)

Related ACOG Guideline: Influenza Vaccination During Pregnancy (free)

“maternal influenza vaccination is not associated with harmful effects on birth outcomes. The beneficial effects reported from previous studies on preterm birth, low birth weight, and fetal death could not be confirmed.”

 


Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

 

Related Commentary on Twitter

 


The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

 

Related Commentary on Twitter

 


Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ (free)

Related: Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention (link to abstract and commentary) AND NICE Guideline: Vitamin D Supplementation (free)

Vitamin D supplementation was not associated with all-cause mortality, cardiovascular mortality, or non-cancer, non-cardiovascular mortality. However, Vitamin D supplementation statistically significantly reduced the risk of cancer death by 16%.

 

Related Commentary on Twitter

 


Medications Affecting the Biochemical Conversion to Type 2 Diabetes: A Systematic Review and Meta-Analysis – The Journal of Clinical Endocrinology & Metabolism (free)

α-Glucosidase inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, metformin, orlistat, phentermine/topiramate, and pioglitazone significantly reduced the risk of biochemical conversion to T2DM, whereas statins and nateglinide increased the risk”

 


Lifestyle changes for treating psoriasis – Cochrane Library (free)

 

Related Commentary on Twitter

 


Association of Early Interventions With Birth Outcomes and Child Linear Growth in Low-Income and Middle-Income Countries: Bayesian Network Meta-analyses of Randomized Clinical Trials – JAMA Network Open (free)

 

Related Commentary on Twitter

 


Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis – The BMJ (free)

Commentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)

“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”

 

Related Commentary on Twitter

 


Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis – The BMJ (free)

Editorial: Preventable harm: getting the measure right (free)

Commentaries: One in 20 patients exposed to preventable harm in medical care – OnMedica (free) AND Half of All Patient Harms ‘Preventable’ – Medscape (free registration required)

 

Related Commentary on Twitter

 


Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis – Stroke (free)

Source: EvidenceAlerts

“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.

 


Surgical interventions for women with stress urinary incontinence: systematic review and network meta-analysis of randomised controlled trials – The BMJ (free)

Related Commentary on Twitter


Preventive lipid‐based nutrient supplements given with complementary foods to infants and young children 6 to 23 months of age for health, nutrition, and developmental outcomes – Cochrane Library (free)

Summary: Effect of lipid-based nutrient supplementation on infants and young children – Cochrane Library (free)

Related Commentary on Twitter


Positional therapy for obstructive sleep apnoea – Cochrane Library (free)

Summary: Are interventions to keep people sleeping on their side the best way to treat obstructive sleep apnoea? – Cochrane Library (free)

 

Related Commentary on Twitter

 


Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis – PLOS Medicine (free)

Source: EvidenceAlerts

“Our findings suggest that to provide clinical benefit with the least effect on growth, the number of repeat treatment courses should be limited to a maximum of three and the total dose to between 24 mg and 48 mg.”