Open access
Open access
Commentaries: Identifying Risk of Psychosis in a Primary Care Setting – JAMA Network Open (free) AND Spotting patients at risk for psychosis: 12 high-risk symptoms – Univadis (free registration required)
Potential Risks and Benefits of Mental Health Screening of Physicians – JAMA (free for a limited period)
Attention Deficit–Hyperactivity Disorder and Month of School Enrollment – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: When starting school, younger children are more likely to be diagnosed with ADHD – Harvard Medical School (free) AND Youngest Children In A Class Are Most Likely To Get ADHD Diagnosis – NPR (free) AND Younger school entry could set stage for ADHD diagnosis – Associated Press (free)
Related: Systematic Review: Youngest in Class More Likely to be Diagnosed with ADHD (free study and commentaries)
Commentaries: Study finds alternative to antipsychotic medication for seniors also has drawbacks – The Globe and Mail (free) AND Trazadone linked to more falls, major fractures in dementia patients – UPI (free) AND Trazadone associated with similar risk of falls and major fractures as antipsychotics in seniors with dementia – Canadian Medical Association Journal (free) AND Aggression in Dementia: Alternatives to Antipsychotics Also Have Side Effects – MedicalResearch.com (free)
Commentary: Adverse Mental Health Outcomes in Breast Cancer Survivors – The ASCO Post (free)
“There is compelling evidence of an increased risk of anxiety, depression and suicide, and neurocognitive and sexual dysfunctions in breast cancer survivors compared with women with no prior cancer.”
Association of Concussion with the Risk of Suicide: A Systematic Review and Meta-Analysis – JAMA Surgery (link to abstract – $ for full-text)
Commentaries: Concussions tied to doubled risk of suicide – Reuters (free) AND Suicide Risk Doubles After Concussion – Medscape (free registration required)
Replication failures in psychology not due to differences in study populations – Nature (free)
Related: Evaluating the Replicability of Social Science Experiments (link to abstract and commentaries) AND Essay: The Experiments Are Fascinating. But Nobody Can Repeat Them – The New York Times (10 articles per month are free)
Antipsychotic drug use and pneumonia: Systematic review and meta-analysis – Journal of Psychopharmacology (link to abstract – $ for full-text)
Commentary: Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests – Psychiatric News Alert (free)
“Although antipsychotic use was associated with a higher risk of pneumonia, the researchers stopped short of claiming causality, citing a lack of data from randomized, controlled trials and a failure of observational studies to control for relevant confounders like tobacco use and weight.” (from Psychiatric News Alert)
Editorials: Screening for Unhealthy Alcohol Use (free) AND Unhealthy Alcohol Use in Primary Care—The Elephant in the Examination Room (free)
Author Interview: USPSTF Recommendation: Screening and Interventions for Unhealthy Alcohol Use (free audio)
JAMA Patient Page: Screening and Counseling to Reduce Unhealthy Alcohol Use (free)
Perioperative alcohol cessation intervention for postoperative complications – Cochrane Library (free)
Summary: Effects of perioperative alcohol cessation interventions on postoperative complications following surgery – Cochrane Library (free)
“Intensive alcohol cessation interventions offered for four to eight weeks to participants undergoing all types of surgical procedures to achieve complete alcohol cessation before surgery probably reduced the number of postoperative complications.”
Guideline: Management of physical health conditions in adults with severe mental disorders – World Health Organization (free PDF)
News Release: WHO guidelines: Management of physical health conditions in adults with severe mental disorders (free)
WHO Video: Improving the physical health of people with severe mental disorders (free)
One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory – Journal of Clinical Psychiatry (link to abstract – $ for full-text)
Commentaries: When Adolescents Give Up Pot, Their Cognition Quickly Improves – NPR (free) AND Stopping Cannabis Tied to Memory Improvements – NEJM Journal Watch (free)
What Works in Youth Suicide Prevention? A Systematic Review and Meta-Analysis – EclinicalMedicine (free)
Related: 800,000 People Kill Themselves Every Year. What Can We do? (free Guidelines and commentary) AND Recommended Standard Care for People with Suicide Risk (free Guideline and commentary) AND Preventing Teen Suicide: What Does the Evidence Shows (free Guideline and commentary) AND AAP Clinical Report: Suicide and Suicide Attempts in Adolescents (free)
Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: E-therapy may help ease insomnia – Reuters (free) AND Some Apps May Help Curb Insomnia, Others Just Put You To Sleep – NPR (free) AND Insomnia symptoms, overall health improve with online insomnia program – Northwestern University (free)
Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness – New England Journal of Medicine (free for a limited period)
Editorial: Dopamine Antagonists in ICU Delirium (free for a limited period)
Commentaries: Common use of antipsychotics shown ineffective for delirium in intensive care patients – NIH News Releases (free) AND Antipsychotic Drugs Don’t Ease ICU Delirium Or Dementia – NPR (free) AND Antipsychotics ineffective for treating ICU delirium – Vanderbilt University Medical Center (free)
Related Research: Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium (free)
Antidepressant withdrawal: reviewing the paper behind the headlines – The Mental Elf (free) (via @AllenFrancesMD)
Original Systematic Review: Antidepressant Withdrawal Effects (free article and commentaries)
“Last week a new review said: – Over half of people taking antidepressants experience withdrawal symptoms – These symptoms are severe in over half of cases. The press had a field day! Our blog today by @J_F_Hayes and @sameerjauhar offers a different view” (via @Mental_Elf see Tweet)
Attention deficit hyperactivity disorder late birthdate effect common in both high and low prescribing international jurisdictions: systematic review – The Journal of Child Psychology and Psychiatry (free) (via @AllenFrancesMD)
Commentary: Global study finds youngest in class more likely to be diagnosed with ADHD – University of Adelaide (free)
Association of Depression With Risk of Incident Systemic Lupus Erythematosus in Women Assessed Across 2 Decades – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: Depression May Increase Risk of Developing an Autoimmune Disease – MedicalResearch.com (free) AND Depression Tied to Double the Risk for Lupus in Women – Medscape (free registration required)
The Lancet Commission on global mental health and sustainable development (free registration required)
Commentaries: Mental health crisis could cost the world $16 trillion by 2030 – Reuters (free) AND Mental health disorders will cause ‘monumental suffering’ and cost £12 TRILLION a year worldwide by 2030 – The Daily Mail (free) AND World in mental health crisis of ‘monumental suffering’, say experts – The Guardian (free)
800,000 people kill themselves every year. What can we do? – The Guardian (free) (via @onisillos)
Related Guidelines: Preventing suicide: A community engagement toolkit – World Health Organization (free PDF) AND Preventing suicide in community and custodial settings – National Institute for Health and Care Excellence (free)
“In too many places mental health support services are non-existent and those with treatable conditions are criminalized. Bold action is long overdue”
A Population-Based Analysis of the Relationship Between Substance Use and Adolescent Cognitive Development – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Teen cannabis use is not without risk to cognitive development – Université de Montréal (free) AND Cannabis ‘more harmful than alcohol’ for teen brains – BBC (free)
Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)
Related: Antidepressant Withdrawal Syndrome (free review and NYT article)
See also: SAFER High Impact Strategies (free)
Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries)
Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentaries: Limiting children’s recreational screen time to less than 2 hours a day linked to better cognition – The Lancet (free) AND Limiting children’s screen time linked to better cognition, study says – CNN (free) AND Limiting children’s screen time linked to better cognition – BBC (free)
“Researchers said more work was now needed to better understand the effects of different types of screen use. However, they acknowledge that their observational study shows only an association between screen time and cognition and cannot prove a causal link.” (from BBC)
Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial – JAMA Psychiatry (free for a limited period) (via @EricTopol)
Commentary: Insomnia symptoms, overall health improve with online insomnia program – Northwestern University (free)
Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies – Molecular Psychiatry (link to abstract – $ for full-text)
Commentaries: Plant-rich diets may help prevent depression – new evidence – The Conversation (free) AND Eating a Mediterranean diet ‘may lower your risk of depression’ – NHS Choices (free) AND Expert reaction to observational studies on diet and depression – Science Media Centre (free) AND Mediterranean diet could prevent depression, new study finds – CNN (free)
“The current evidence is not sufficient to prove plant-rich diets can prevent depression as most of the evidence so far simply shows that those with poorer mental health eat worse, so it may be that those more prone to depression also choose less health” (from CNN)
Global status report on alcohol and health 2018 – World Health Organization (free PDF)
News Release: Harmful use of alcohol kills more than 3 million people each year, most of them men (free)
Commentaries: Alcohol abuse kills 3 million a year, most of them men: WHO – Reuters (free) AND 1 in 20 deaths globally is a result of alcohol use – CNN (free) AND Alcohol causes one in 20 deaths worldwide, says WHO – The Guardian (free)
The cost of persuasive design: digital media use and ADHD – The Mental Elf (free)
Original Study: Association of Digital Media Use with ADHD Among Adolescents (link to abstract and free commentaries)
Prevalence of Burnout Among Physicians: A Systematic Review – JAMA (link to abstract – $ for full-text)
Commentaries: Doctors Today May Be Miserable, But Are They ‘Burnt Out’? – NPR (free) AND Physician burnout taking center stage – Reuters (free) AND Burnout Found to Be Common Among U.S. Resident Physicians – Psychiatric News Alert (free)
Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians (free) AND The Burnout Crisis in American Medicine – The Atlantic (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record (free commentaries)
Implementing Optimal Team-Based Care to Reduce Clinician Burnout – National Academy of Medicine (free)
Commentaries: Optimal team-based health care is associated with improved patient outcomes and physician well-being – ACP Newsroom (free) AND New Review Shows Team-Based Care May Reduce Physician Burnout – Medscape (free registration required)
Factors Associated With Long-term Benzodiazepine Use Among Older Adults – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: 1 in 4 Older Adults Prescribed a Benzodiazepine Goes on to Risky Long-Term Use, Study Finds – Michigan Medicine, via NewsWise (free) AND Long-Term Benzodiazepine Use Common Among Older Adults – Physician’s First Watch (free) AND Factors Predicting Long-term Benzodiazepine Use Identified – Medscape (free registration required) AND Larger Number of Benzodiazepine Pills in Initial Prescription Associated With Long Term Use – MedicalResearch.com (free)
Related: A Quiet Drug Problem Among the Elderly – The New York Times (free) AND Our Other Prescription Drug Problem – New England Journal of Medicine (free) AND Benzodiazepines: our other prescription drug epidemic – STAT (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)
Preventing suicide A community engagement toolkit – World Health Organization (free PDF)
Fact Sheet: Suicide – World Health Organization(free)
Editorial: Pain, Opioids, and Suicide Mortality in the United States (free)
Commentaries: Chronic pain may contribute to suicide, study warns – Reuters(free) ANDChronic Pain Tied to Increased Suicide Risk – NEJM Physician’s First Watch(free) AND Increasing rates of chronic pain found among those who die by suicide – ACP Internist(free)
Preventing Cognitive Decline in Black Individuals With Mild Cognitive Impairment: A Randomized Clinical Trial – JAMA Neurology (free for a limited period)
Commentary: Study provides evidence to prevent memory decline in older blacks with mild cognitive impairment – News Medical (free) AND Novel Intervention Markedly Slows Cognitive Decline in MCI – Medscape (free registration required)
Antidepressants for treating depression in dementia – Cochrane Library (free for a limited period)
Summary: Antidepressants for treating depression in dementia – Cochrane Library (free)
“On the only measure of efficacy for which we had high-quality evidence (depression rating scale scores), antidepressants showed little or no effect.”
Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015 – Nature Human Behavior (free for a limited period)
Commentaries: More social science studies just failed to replicate. Here’s why this is good – VOX (free) AND High-profile journals put to reproducibility test – Nature News (free) AND ‘Replication crisis’ spurs reforms in how science studies are done – ScienceNews (free) AND The Science Behind Social Science Gets Shaken Up—Again – WIRED (Free) AND In Psychology And Other Social Sciences, Many Studies Fail The Reproducibility Test – NPR (free)
“We replicated 21 social science experiments in Science or Nature. We succeeded with 13. Replication effect sizes were half of originals.” (via @BrianNosek see Tweet)
Commentaries: Distress boosts heart attack and stroke risk – Medical News Today (free) AND High Mental Distress Tied to Heart Troubles – MedPage Today (free registration required)
Exploring the Relationship Between Depression and Dementia – JAMA (free for a limited period)
Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Pregabalin may increase the risk of death when coprescribed with opioids – 2 Minute Medicine (free) AND Pregabalin Linked To Increased Risk for Opioid-Related Deaths – MedicalResearch.com (free) AND Anticonvulsant With Opioids Tied To Higher Mortality – MedPage Today (free registration required)
Association Between Traumatic Brain Injury and Risk of Suicide – JAMA (link to abstract – $ for full-text)
Commentaries: Traumatic brain injury tied to increased risk of suicide – Reuters (free) AND Risk of Suicide Increases After TBI, Study Finds – Psychiatric News Alert (free) AND Expert reaction to traumatic brain injury and suicide – Science Media Centre (free)
Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: Switching Anti-Psychotic Medications Doesn’t Improve Outcomes in First-Episode Schizophrenia Patients – Mount Sinai (free) AND No Benefit of Switching Antipsychotics in Early Schizophrenia – Medscape (free registration required) AND No Gain with Antipsych Meds Switch in Schizophrenia – MedPage Today (free registration required)
Opioid prescribing decreases after learning of a patient’s fatal overdose – Science (free for a limited period)
Commentary: Notification of patient overdose deaths reduces clinician opioid prescriptions – NIH News Releases (free) AND Clinicians were told their patient had died of an overdose. Then opioid prescribing dropped – STAT (free)
Commentaries: Refining treatment choices for ADHD – The Lancet Psychiatry (free) AND ADHD medications: Of all available drugs, methylphenidate should be first option for short-term treatment in children – ScienceDaily (free) AND Analysis of ADHD Drugs: Use Methylphenidate in Kids, Amphetamines in Adults – Physician’s First Watch (free)
Related: Cochrane Review: Adverse Events of Methylphenidate for ADHD in Children and Adolescents (link to abstract and free summary) AND Short Review: Stimulants for ADHD in children (free) AND Opinion: Drug treatment of ADHD – tenuous scientific basis (free)
Commentary: Higher alcohol taxes are cost-effective in reducing alcohol harms – ScienceDaily (free)
Related: To improve global health, tax the things that are killing us – Financial Times (free policies, articles and commentaries) AND Policy lessons from health taxes (free research and commentaries)
See also: Full Report (free PDF) AND Evidence Summary (free PDF)
Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: Expert reaction to physical activity linked to improved mental health – Science Media Centre (free) AND Regular exercise ‘best for mental health’ – BBC (free) AND Exercise is good for your body and your mind, study says – CNN (free)
Commentaries: Peer-delivered self-management programmes in mental health – The Lancet (free) AND After the crisis: self-management and peer-support – The Mental Elf (free) AND Peer Support Helps Reduce Mental Crisis Readmissions – MedPage Today (free registration required)
The association between suicide deaths and putatively harmful and protective factors in media reports – Canadian Medical Association Journal (free) (via @IrfanDhalla)
Invited Commentary: Responsible reporting to prevent suicide contagion (free for 1 week)
Drinking or Smoking While Breastfeeding and Later Cognition in Children – Pediatrics (free)
Commentaries: Study: Drinking while breastfeeding linked with children’s reasoning deficits – AAP News (free) AND Alcohol in breast milk may lead to lower cognition in kids, study finds – CNN (free) AND Fuel For Mommy Shaming: Breastfeeding And Alcohol Study Deeply Misleading – Forbes (free)
A Systematic Review and Meta‐analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department – Academic Emergency Medicine (link to abstract – $ for full-text)
Commentaries: Low-Dose Ketamine Offers Effective Alternative to Opioids in Treatment of Acute Pain, Meta-Analysis Suggests – Psychiatric News Alert (free) AND Ketamine vs Opioids for Acute Pain in the Emergency Department – MedicalResearch.com (free) AND Low-Dose Ketamine May Be a Safe Opioid Alternative, Review Confirms – Medscape (free registration required) AND Ketamine could help reduce opioid use in the ER – Medical News Today (free)
Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Treating Depression May Improve Cardiac Outcomes, Research Finds – AJMC (free) AND Treating depression may prevent repeat heart attack, study says – UPI (free)
Prevalence of Depression Among Fathers at the Pediatric Well-Child Care Visit – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: New dads need depression screening, too – Reuters (free) AND New Dads as Likely to Suffer From Depression as Moms, Study Suggests – Medscape (free registration required)
Physicians aren’t ‘burning out.’ They’re suffering from moral injury – STAT (free)
Related: The Burnout Crisis in American Medicine (free commentaries on the subject) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and free commentaries)
Antidepressant Withdrawal Syndrome – Therapeutics Initiative (free)
Related Perspective: Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)
“Antidepressants should be added to the list of drugs associated with tolerance, dependence and a withdrawal syndrome.”
“Withdrawal symptoms occur in at least one-third of patients who stop.”
Association of Digital Media Use With Subsequent Symptoms of Attention-Deficit/Hyperactivity Disorder Among Adolescents – JAMA (link to abstract – $ for full-text)
Commentaries: More Screen Time For Teens Linked To ADHD Symptoms – NPR (free) AND Digital media use linked to behavioral problems in kids – University of Southern California, via ScienceDaily (free) AND Screen time linked to ADHD symptoms in teens – Reuters (free) AND ADHD study links teens’ symptoms with digital media use – CNN (free) AND Expert reaction to association of digital media use and ADHD symptoms among teenagers – Science Media Centre (free)
Comparison of the Safety Planning Intervention With Follow-up vs Usual Care of Suicidal Patients Treated in the Emergency Department – JAMA Psychiatry (free for a limited period)
Author Interview: Association of Safety Planning Intervention With Subsequent Suicidal Behavior Among ER-Treated Suicidal Patients (free)
Commentaries: ED Intervention with Follow-Up Appears to Reduce Suicidal Behaviors – NEJM Physician’s First Watch (free) AND A Simple Emergency Room Intervention Can Help Cut Suicide Risk – NPR (free)
Related Studies: Suicide Prevention in an Emergency Department Population (free study and commentaries) AND Strategies to prevent death by suicide (link to abstract and commentaries)
Physician Burnout, Well-being, and Work Unit Safety Grades in Relationship to Reported Medical Errors – Mayo Clinic Proceedings (link to abstract – $ for full-text)
Commentaries: Medical errors may stem more from physician burnout than unsafe health care settings – Stanford Medicine, via ScienceDaily (free) AND Physician burnout, depression can lead to major medical errors: Study – ABC News (free) AND Burnout Tied to Twofold Higher Risk for Medical Errors – Medscape (free registration required)
Related: Perspective: The Burnout Crisis in American Medicine (free commentaries on the subject)
Use of ‘smart drugs’ on the rise – Nature (free)
Related: A ‘smart’ approach to performance drugs – ACP Internist (free) AND Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)
Risk of weight gain for specific antipsychotic drugs: a meta-analysis – npj Schizophrenia (free)
Related Study: Cohort Study: Weight Gain with Antidepressant Utilization (free research and commentaries)
Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies – The Lancet (link to abstract – $ for full-text)
Commentaries: Increased risk of birth defects in babies after first-trimester exposure to lithium – Mount Sinai School of Medicine, via ScienceDaily (free) AND Lithium in Pregnancy Tied to Infant Morbidity, Malformation Risk – Medscape (free)
Opinion: Endless Gaming May Be a Bad Habit. That Doesn’t Make It a Mental Illness – The New York Times (10 articles per month are free)
Related: Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free)
“The World Health Organization has made “internet gaming” a diagnosable disorder. But many experts aren’t even sure it exists”.
A Randomized Controlled Trial of Parent-Child Psychotherapy Targeting Emotion Development for Early Childhood Depression – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Parent-Child Psychotherapy Leads to Improvements in Young Children With Depression – Psychiatric News Alert (free) AND Psychotherapeutic intervention shows promise for treating depression in preschool-aged children – NIH News Releases (free) AND Parent-child therapy helps young children with depression – Washington University School of Medicine, via ScienceDaily (free)
Related Study: Talking therapy given by parents shows promise for childhood anxiety disorders (free research, editorial and commentaries)
Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study – Journal of Clinical Psychopharmacology (link to abstract – $ for full-text)
Commentaries: Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants – MPR (free) AND Antidepressants tied to Parkinson’s-like symptoms – Univadis (free registration required)
“Observational study: Incidence of EPSs with antidepressants. RRs: duloxetine, 5.68; mirtazapine, 3.78; citalopram, 3.47; escitalopram, 3.23; paroxetine, 3.07; sertraline, 2.57; venlafaxine, 2.37; bupropion, 2.31; and fluoxetine, 2.03 (all significant)” (via @psychopharmacol see Tweet)
Intramuscular Midazolam, Olanzapine, Ziprasidone, or Haloperidol for Treating Acute Agitation in the Emergency Department – Annals of Emergency Medicine (link to abstract – $ for full-text)
Commentary: Agitation in ED: a comparative study of fast-acting sedatives – Univadis (free)
Metabolic Effects of Antipsychotics on Adiposity and Insulin Sensitivity in Youths: A Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Study First to Show Antipsychotic Medication Use in Youths Increases Diabetes Risk, Body Fat – Florida Atlantic University, via NewsWise (free) AND Rapid Weight Gain, Decreased Insulin Sensitivity Found in Youth Taking SGAs for First Time – Psychiatric News Alert (free) AND Kids on Antipsychotics May See Adverse Metabolic Effects – MedPage Today (free registration required)
Prevalence of Prescription Medications With Depression as a Potential Adverse Effect Among Adults in the United States – JAMA (link to abstract – $ for full-text)
Commentaries: One-Third of US Adults May Unknowingly Use Medications That Can Cause Depression – University of Illinois at Chicago, via EurekAlert (free) AND Many U.S. adults take medicines that can cause depression – Reuters (free) AND Rx With Depression as Potential Adverse Effect Widely Used – Medscape (free registration required)
Commentaries: CDC: U.S. Suicide Rates Have Climbed Dramatically – NPR (free) AND CDC: Suicide rates rose 30% across nation since 1999 – UPI (free) AND More Americans Are Dying From Suicide – The Atlantic (free)
Associations between age and the course of major depressive disorder: a 2-year longitudinal cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: Older age tied to poorer course of major depressive disorder – MedicalXpress (free) AND Worse Depression Trajectory in Old Age – MedPage Today (free registration required)
Commentaries: Very late-onset schizophrenia-like psychosis: positive findings but questions remain unanswered – The Lancet Psychiatry (free) AND Low-Dose Antipsychotic Effective in Late-Onset Psychosis – Medscape (free registration required) AND Low-dose amisulpride effective for late-onset psychosis – Healio (free registration required)
Association of Hypertensive Disorders of Pregnancy With Risk of Neurodevelopmental Disorders in Offspring: A Systematic Review and Meta-analysis – JAMA Psychiatry (free for a limited period)
Commentary: Hypertension in Pregnancy Tied to Autism, ADHD – MedPage Today (free registration required)
“Researchers call for greater pediatric surveillance of infants in hypertensive moms” (from MedPage Today)
Mental Health ATLAS 2017 – World Health Organization (free PDF)
News Release: Mental health: massive scale-up of resources needed if global targets are to be met (free)
See also: WHO Campaign on Mental Health (free resources)
“Every US$ 1 invested in scaling up treatment for common mental illnesses such as depression and anxiety leads to a return of US$ 4 in better health and ability to work” (via @WHO see Tweet)
Stimulants for ADHD in children: Revisited – Therapeutics Initiative (via @AllenFrancesMD)
“There is convincing evidence that a proportion of boys and girls treated with stimulants in BC and around the world are simply the youngest in their class”
Dieting predicts engagement in multiple risky behaviours among adolescent Canadian girls: a longitudinal analysis – Canadian Journal of Public Health (link to abstract – $ for full-text)
Commentary: Dieting associated with risky behaviors in teenage girls – University of Waterloo, via ScienceDaily (free)
Has suicide become an occupational hazard of practicing medicine? – CMAJ News (free)
Related: Preventing physician suicide – ACP Hospitalist (free) AND What I’ve learned from my tally of 757 doctor suicides – The Washington Post (free) AND Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT (free) AND Protecting interns and other physicians from depression and suicide – STAT (free)
“Our work environments are unhealthy and it’s supported by a culture of giving and made worse in modern times by a culture of efficiencies and bureaucracies”
Editorial: Antidepressant induced weight gain (free)
Commentaries: Antidepressant therapy and risk of weight gain – The BMJ Opinion (free) AND Taking antidepressants could be linked to weight gain, according to a new study — and some drugs heighten the risk more than others – Business Insider (free) AND Antidepressants linked to risk of weight gain, study shows – OnMedica (free) AND Antidepressant use linked with weight gain – NHS Choices (free)
Committee Opinion: Gynecologic Care for Adolescents and Young Women With Eating Disorders – American College of Obstetricians and Gynecologists (free)
News Release: Ob-Gyns Have Important Role on Care Team for Women with Eating Disorders – ACOG (free)
Commentary: OB/GYN Group Offers Advice on Caring for Teens, Young Women with Eating Disorders – Physician’s First Watch (free)
The role of job strain in understanding midlife common mental disorder: a national birth cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: How job strain may impair mental health – Medical News Today (free) AND Job strain linked to onset of common mental illness – Black Dog Institute, via MedicalXpress (free) AND Job Stress May Be a ‘Substantial Contributor’ to Mental Illness – Medscape (free registration required)
Autism spectrum disorder: advances in diagnosis and evaluation – The BMJ (free for a limited period)
Pediatric ADHD Medication Exposures Reported to US Poison Control Centers – Pediatrics (link to abstract – $ for full-text)
Commentaries: Unnecessary and accidental use of ADHD drugs increases over 60%, study suggests – CNN (free) AND Add ADHD Meds To Call Burden For Poison Control Centers – American Council on Science and Health (free) AND As ADHD Diagnoses Increased, So Did Calls to Poison Control – U.S. News (free) AND More U.S. kids overdosing on ADHD drugs – Reuters (free)
Commentaries: Emergency hospital admissions for alcohol a red flag for suicide risk – new study – Public Health Wales (free) AND Alcohol-Related Emergency Admissions: A Marker for Suicide Risk – NEJM Journal Watch (free for a limited period)
Dose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized, Double-Blind Trials – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)
Commentary: Depression: boosting SSRIs doesn’t work – Univadis (free registration required)
“Meta-analysis: there is evidence from RCTs against increasing the dose of SSRIs (with the possible exception of citalopram) in adult patients with major depression and antidepressant treatment failure” (via @psychopharmacol see Tweet)
Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank – The Lancet Psychiatry (link to abstract – for full-text)
Commentaries: Disrupted sleep-wake cycle linked to mental health problems – new study – The Conversation (free) AND Study: Body clock disruption linked to mood disorders – UPI (free) AND Body clock disruptions linked to mood disorders – NHS Choices (free) AND Maintaining a daily rhythm is important for mental health, study suggests – CNN (free)
Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free) (via @Deprescribing)
Related: CaDeN Deprescribing Guidelines and Algorithms (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)
Association of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: Resistance Exercise Might Improve Depression Symptoms – NEJM Physician’s First Watch (free) AND Resistance exercise may reduce depressive symptoms in adults – MedicalXpress (free) AND Resistance Exercise Training May Alleviate Some Depressive Symptoms – MedicalResearch.com (free)
Global statistics on alcohol, tobacco and illicit drug use: 2017 status report – Addiction (free PDF)
Commentaries: Alcohol and tobacco are by far the biggest threat to human welfare of all addictive drugs – Society for the Study of Addiction, via ScienceDaily (free) AND Which drugs pose the biggest threat to public health? – Medical News Today (free)
Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of adverse events in non-randomised studies – Cochrane Library (link to abstract – $ for full-text)
“Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate”.
Cost-effectiveness of Electroconvulsive Therapy vs Pharmacotherapy/Psychotherapy for Treatment-Resistant Depression in the United States – JAMA Psychiatry (free for a limited period)
Author interview: Cost-effectiveness of Electroconvulsive Therapy for Treatment-Resistant Depression in the United States (free)
Commentaries: Study about ‘shock therapy’ for depression suggests more patients should try it sooner – Michigan Medicine – University of Michigan, via EurekAlert (free) AND Third-Line Electroconvulsive Therapy May Be Best for Patients With Treatment-Resistant Depression – Psychiatric News Alert (free) AND ECT Found Cost Effective Early in Depression Treatment – MedPage Today (free registration required)
Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Author Interview: Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults (free)
Commentaries: Psychological interventions can help treat chronic pain in seniors – UPI (free) AND Not All In Your Head: Psychological Therapies Not a Panacea for Pain – MedicalResearch.com (free)
Antidepressants for the treatment of people with co-occurring depression and alcohol dependence – Cochrane Library (link to abstract and summary – $ for full-text)
Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression – JAMA Psychiatry (free for a limited period)
Commentaries: With Early Intervention, Patients With Schizophrenia Experience Greater Improvements in Health, Function – Psychiatric News Alert (free) AND Early Intervention Best for Early-Phase Psychosis – MedPage Today (free registration required)
Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Regular exercise may help lower your risk of depression – NHS Choices (free) AND Regular Exercise Lowers Odds of Developing Depression, Meta-Analysis Finds – Psychiatric News Alert (free)
Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Three-Minute Brain Stimulation Sessions Effectively Reduce Depression Symptoms, Study Finds – Forbes (free) AND Three Minute Version of Brain Stimulation Therapy Effective for Hard to Treat Depression – Neuroscience News (free)
Commentaries: Moderate to severe mid-life anxiety may be linked to later life dementia – BMJ Open Blog (free) AND Anxiety in middle age linked to dementia later – Reuters (free) AND Expert reaction to a review of the association between mid-life anxiety and later life dementia – Science Media Centre (free)
“The current study isn’t designed to explain how anxiety and dementia might be connected, Iadecola added.
“We cannot say with confidence that anxiety is a cause (risk factor), an early manifestation of the dementia, or only coincidentally associated with it,”” (from Reuters)
Anticholinergic drugs and risk of dementia: case-control study – The BMJ (free)
Editorial: Anticholinergic drugs and dementia in older adults (free)
Commentaries: Expert reaction to study investigating the association between different types of anticholinergic drugs and risk of dementia – Science Media Centre (free) AND Anticholinergic drugs may be linked to increased risk of dementia – OnMedica (free)
“The effect of anticholinergic therapy is relatively small (odds ratio 1.1 – 1.2) and establishing an association does not prove a causal link. Nevertheless, the paper may act as a useful guide for future research and clinical practice”. (by Prof Les Iversen, in Science Media Centre)
Guideline Update: Depression in adults: recognition and management – National Institute for Health and Care Excellence (free)
Genome-wide association analyses identify 44 risk variants and refine the genetic architecture of major depression – Nature Genetics (link to abstract – $ for full-text)
Commentaries: Unprecedented study identifies 44 genetic risk factors for major depression – King’s College London, via MedicalXpress (free) AND ‘Gene map for depression’ sparks hopes of new generation of treatments – The Guardian (free) AND Global study finds 44 genetic risk factors for major depression – Reuters (free)
Related Guideline: Bipolar disorder: assessment and management – National Institute for Health and Care Excellence (free)
Efficacy and Safety of Intranasal Esketamine for the Rapid Reduction of Symptoms of Depression and Suicidality in Patients at Imminent Risk for Suicide: Results of a Double-Blind, Randomized, Placebo-Controlled Study – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Intranasal Esketamine Found Effective in Rapid Reduction of Depression, Suicidal Thoughts – Psychiatric News Alert (free) AND Fast-acting benefits of ketamine for depression and suicidality – American Psychiatric Association, via ScienceDaily (free) AND Ketamine ‘shows promise’ in treating depression – OnMedica (free) AND Ketamine Spray Effective for Suicidality, but Abuse Concerns Linger – Medscape (free registration required)
Related: ‘Cautious Optimism’ Marks Outlook for Ketamine, Mood Disorders – Psychiatric News (free)
Association of Cannabis With Cognitive Functioning in Adolescents and Young Adults: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: Marijuana’s effects on young brains diminish 72 hours after use, research says – CNN (free) AND ‘Poorer Cognitive Functioning’ of Marijuana Users Detailed in New Study – Inverse (free)
News Release: New Recommended Standard Care for People with Suicide Risk Aims to Fundamentally Improve Suicide Care Delivered Nationwide (free PDF)
Commentary: First-Ever Suicide Prevention Recommendations Released – Medscape (free registration required)
Perspective: Digital Addiction: A Recipe For Isolation, Depression And Anxiety – Forbes (free)
Original article: Digital Addiction: Increased Loneliness, Anxiety, and Depression – NeuroRegulation (free PDF)
Editorial: Thresholds for safer alcohol use might need lowering (free)
Commentaries: Drinking a pint of beer may lower your life expectancy by the same amount as smoking a cigarette – new research – The Conversation (free) AND Expert reaction to study looking at drinking alcohol, life expectancy and alcohol limits – Science Media Centre (free) AND More than six weekly glasses of wine could curb life expectancy by up to five years – OnMedica (free) AND Consuming more than five drinks a week could shorten your life – University of Cambridge, via ScienceDaily (free) AND How much alcohol is too much? A new study says it’s found the number – PBS News Hour (free)
Non-invasive brain stimulation techniques for chronic pain – Cochrane Library (free)
“There is a lack of high-quality evidence to support or refute the effectiveness of non-invasive brain stimulation techniques for chronic pain”
Antidepressants versus placebo for panic disorder in adults – Cochrane Library (link to abstract – $ for full-text)
Summary: Antidepressants for panic disorder in adults – Cochrane Library (free)
Commentary: Antidepressants are moderately effective in panic disorder – Univadis (free registration required)
Let It Go: Lingering Negative Affect in Response to Daily Stressors Is Associated With Physical Health Years Later – Psychological Science (link to abstract – $ for full-text)
Commentaries: Lingering negative responses to stress linked with health a decade later – Association for Psychological Science, via ScienceDaily (free) AND Even minor stress can impact long-term health, study warns – Medical News Today (free)
Associations Between Brain Structure and Connectivity in Infants and Exposure to Selective Serotonin Reuptake Inhibitors During Pregnancy – JAMA Pediatrics (free for a limited period)
Author interview: Associations Between SSRI Exposure During Pregnancy and MRI-Assessed Brain Structure and Connectivity in Infants (free)
Commentaries: We’re beginning to learn how moms’ antidepressants can affect fetuses – VOX (free) AND MRI study finds prenatal exposure to certain antidepressants may alter brain development – Health Imaging (free) AND SSRI use in pregnancy may affect fetal brain development – OnMedica (free) AND Antidepressants in pregnancy tied to changes in babies’ brains – Reuters (free)
Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)
Commentaries: Quitting Facebook can reduce stress – University of Queensland (free) AND Giving up Facebook leads to a drop in the stress-related hormone cortisol, study finds – PsyPost (free) AND Does Quitting Facebook Really Make You Less Happy? Probably Not – Forbes (free) AND Want to de-stress? Delete Facebook, study suggests – Medical News Today (free)
Commentary: Sleep deficiency increases risk of a motor vehicle crash – Brigham and Women’s Hospital, via ScienceDaily (free)
“Study finds that sleep deficiency due to either sleep apnea or insufficient sleep duration is strongly associated with motor vehicle crashes, regardless of one’s self-reported sleepiness level” (from ScienceDaily)
Effectiveness of preventive cognitive therapy while tapering antidepressants versus maintenance antidepressant treatment versus their combination in prevention of depressive relapse or recurrence (DRD study): a three-group, multicentre, randomised controlled trial – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary: Preventive cognitive therapy is an effective alternative and addition to antidepressants for preventing depression relapse, study finds – ACP Internist (free) AND Preventive Cognitive Therapy Helps Limit Depression Recurrence – NEJM Physician’s First Watch (free) AND Depression: preventive cognitive therapy improves outcome in recurrent depression – Univadis (free registration required)
Commentaries: Mindfulness Intervention Can Prevent Depression, Study Finds – Mad in America (free) AND Could mindfulness prevent major depression? – Medical News Today (free) AND Meditation May Reduce Depression in Primary Care – Medscape (free registration required)
Viewpoint: Driving Under the Influence of Cannabis: An Increasing Public Health Concern – JAMA (free for a limited period)
Adjunctive Bright Light Therapy for Bipolar Depression: A Randomized Double-Blind Placebo-Controlled Trial – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Light Therapy Might Help People With Bipolar Depression – NPR (free) AND Bright Light Therapy at Midday Helps Bipolar Patients – Neuroscience News (free) AND Midday Light Therapy May Improve Depressive Symptoms in Patients With Bipolar Disorder – Psychiatry News Alert (free) AND Brighter Days Ahead: Light Therapy Effective for Bipolar Depression – Medscape (free registration required)
Electroconvulsive therapy and risk of dementia in patients with affective disorders: a cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary: ECT for Mood Disorders ‘Does Not Cause Dementia’ – Medscape (free registration required)
Original Article: Cognitive-behavioural interventions for attention deficit hyperactivity disorder (ADHD) in adults – Cochrane Library (link to abstract – $ for full-text)
Preventing physician suicide – ACP Hospitalist (free)
Related: What I’ve learned from my tally of 757 doctor suicides – The Washington Post (free) AND Why are doctors killing themselves? – MJA InSight (free) AND Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT (free) AND Protecting interns and other physicians from depression and suicide – STAT (free)
Commentaries: Mental health risks to girls who spend more than an hour a day on social media – new study – The Conversation (free) AND How much is too much? Does increasing use of social media having a damaging effect on young girls? – BMC Series Blog (free) AND Social Media May Be More Harmful To Girls Than Boys, Study Finds – Forbes (free)
See also a recent Pediatrics supplement: Children, Adolescents and Screens: What We Know and What We Need To Learn (free supplement) and related texts on Social Media and Mental Health (free articles and commentaries)
Suicide After Deliberate Self-Harm in Adolescents and Young Adults – Pediatrics (free)
Commentary: Young People Who Self-Harm Face Striking Increase in Suicide Risk – Physician’s First Watch (free)
“Teens who self-harm are nearly 50 times more likely to commit suicide in the next year compared with their non-self-harming peers” (via @Physns1stWatch see Tweet)
A Quiet Drug Problem Among the Elderly – The New York Times (free)
Related: Our Other Prescription Drug Problem – New England Journal of Medicine (free) AND Benzodiazepines: our other prescription drug epidemic – STAT (free)
“Despite warnings from experts, older people are using more anti-anxiety and sleep medications, putting them at risk of serious side effects and even overdoses”.
Indian Clinical Practice Guidelines for Elderly with Psychiatric & Neurologic Symptoms – Indian Journal of Psychiatry
– The Geropsychiatric Interview- Assessment and Diagnosis (free)
– Clinical practice guidelines for management of dementia (free)
– Clinical practice guidelines for management of delirium in elderly (free)
– Clinical practice guidelines for management of depression in elderly (free)
– Clinical practice guideline for management of psychoses in elderly (free)
– Clinical practice guidelines for geriatric anxiety disorders (free)
– Clinical practice guideline on management of sleep disorders in the elderly (free)
Do Antidepressants Work? – The New York Times (10 articles per month are free)
“The most comprehensive study on them has recently been published, showing mostly modest effects”.
See related meta-analysis and commentaries in our February 23rd issue (see #3)
Preventing the Malignant Transformation of Bipolar Disorder – JAMA (free for a limited period)
Effectiveness of Early Psychosis Intervention: Comparison of Service Users and Nonusers in Population-Based Health Administrative Data – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Early Psychosis Intervention Program Found to Increase Patient Contact With Psychiatrists, Reduce Mortality – Psychiatry News Alert (free) AND Early Psychosis Interventions May Reduce Patient Mortality – PsychCentral (free)
Effectiveness of brief alcohol interventions in primary care populations – Cochrane Library (free)
In general practice or emergency care settings, brief alcohol interventions can reduce alcohol consumption and related harm.
Guidelines for Adolescent Depression in Primary Care – American Academy of Pediatrics
Part I. Practice Preparation, Identification, Assessment, and Initial Management (free)
Part II. Treatment and Ongoing Management (free)
Commentary: Pediatricians Call For Universal Depression Screening For Teens – NPR (free)
Source: Medscape (free registration required)
“Cognitive enhancers in general have minimal effects on cognition according to minimal clinically important difference and global ratings. The drugs appear safe, but this must be interpreted cautiously because trial participants may have less comorbidity and fewer adverse effects than those treated with these drugs in clinical practice”.
Related guideline: Social anxiety disorder: recognition, assessment and treatment – NICE (free) AND Summary: Recognition, assessment and treatment of social anxiety disorder: summary of NICE guidance – The BMJ (free)
Real-World Effectiveness of Pharmacologic Treatments for the Prevention of Rehospitalization in a Finnish Nationwide Cohort of Patients With Bipolar Disorder – JAMA Psychiatry (link to abstract – $ for full-text)
Editorial: Enthusiasm and Skepticism About Using National Registers to Analyze Psychotropic Drug Outcomes (free for a limited period)
Commentaries: Lithium treatment for bipolar disorder linked to lowest risk of rehospitalization – Karolinska Institutet, via EurekAlert (free) AND Lithium Top Choice for Preventing Bipolar Rehospitalization – MedPage Today (free registration required)
Related study: Effectiveness of maintenance therapy of lithium vs other mood stabilizers in monotherapy and in combinations: a systematic review of evidence from observational studies – Bipolar Disorders (free)
These observational studies suggest Lithium may be a better choice for treating these patients, but randomized controlled trials are needed to clarify this issue.
Commentaries: Alcohol and dementia: a complex relationship with potential for dementia prevention – The Lancet Public Health (free) AND Expert reaction to study looking at alcohol use disorders and dementia risk – Science Media Centre (free) AND Heavy Drinking Tied to Early-Onset Dementia in French Study – MedPage Today (free registration required)
“Of 57,000 people diagnosed before age 65 with early-onset dementia, 39% had alcohol-related dementia by definition, and 18% had an additional diagnosis of alcohol use disorders” (via @medpagetoday see Tweet)
The Origin of Spousal Resemblance for Alcohol Use Disorder – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: For Better or Worse: Risk of Alcohol Use Disorder Rises When Spouse is Diagnosed – Psychiatric News Alert (free) AND Spouses have strong influence on risk for alcohol abuse – Reuters (free)
Perspective: Our Other Prescription Drug Problem – New England Journal of Medicine (free)
Related opinion: Benzodiazepines: our other prescription drug epidemic – STAT (free)