The Covid-19 crisis too few are talking about: health care workers’ mental health – STAT

Related: Impact on mental health and perceptions of psychological care among medical and nursing staff in Wuhan during the 2019 novel coronavirus disease outbreak: A cross-sectional study – Brain, Behavior, and Immunity AND Mental Health Needs of Health Care Workers Providing Frontline COVID-19 Care – JAMA Health Forum AND Managing mental health challenges faced by healthcare workers during covid-19 pandemic – The BMJ AND Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019 – JAMA Network Open

Managing mental health challenges faced by healthcare workers during covid-19 pandemic – The BMJ

Related Study: Factors Associated With Mental Health Outcomes Among Health Care Workers Exposed to Coronavirus Disease 2019 – JAMA Network Open AND Commentary: Survey Finds COVID-19 Takes Heavy Psychological Toll on Health Care Workers – Psychiatric News Alert

Association between suicide reporting in the media and suicide: systematic review and meta-analysis – The BMJ (free)

Editorial: Suicide and the media: reporting could cost lives (free)

Commentaries: Responsible communication on suicide in the media is essential if we want to be serious about tackling the stigma surrounding suicide – The BMJ Opinion (free) AND Suicide and the media: reporting could cost lives – University of Bristol (free) AND Media reports of celebrity suicide linked to increased suicide rates – BMJ (free)

Psychotherapy for Depression Across Different Age Groups: A Systematic Review and Meta-analysis – JAMA Psychiatry (free)

Editorial: The Age of Depression and Its Treatments (free)

Commentary: Psychotherapy not as effective for kids, adolescents with depression, study says – UPI (free)

Mental Health and Psychosocial Considerations During COVID-19 Outbreak – World Health Organization (free PDF)

Related: The psychological impact of quarantine and how to reduce it: rapid review of the evidence – The Lancet (free) AND Behavioural scientists form new front in battle against coronavirus – The Guardian (free)

“Minimize watching, reading or listening to news that causes you to feel anxious or distressed; seek information only from trusted sources and mainly to take practical steps to prepare your plans and protect yourself and loved ones.”

Association of Functional, Cognitive, and Psychological Measures With 1-Year Mortality in Patients Undergoing Major Surgery – JAMA Surgery (free for a limited period)

Prevention of Psychosis: Advances in Detection, Prognosis, and Intervention – JAMA Psychiatry (free for a limited period)

Author Interview: Prevention of Psychosis—Advances in Detection, Prognosis, and Intervention (free audio)

Alcoholics Anonymous and other 12‐step programs for alcohol use disorder – Cochrane Library (free)

Author Interview: Alcoholics Anonymous and other 12-step programs for alcohol use disorder (free)

News Release: New Cochrane Review finds Alcoholics Anonymous and 12-Step Facilitation programs help people to recover from alcohol problems (free)

Commentaries: A new, big review of the evidence found that Alcoholics Anonymous works — for some – Vox (free) AND Alcoholics Anonymous validated by meta-analysis: ‘It absolutely does work’ – Stanford Medicine (free)

Efficacy of Gabapentin for the Treatment of Alcohol Use Disorder in Patients With Alcohol Withdrawal Symptoms: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentaries: Drug eases withdrawal, improves abstinence in alcohol use disorder – UPI (free) AND Gabapentin Found to Work Best for Those With Severe Alcohol Withdrawal Syndrome – Psychiatric News Alert (free)

FDA requires Boxed Warning about serious mental health side effects for asthma and allergy drug montelukast (Singulair); advises restricting use for allergic rhinitis – U.S. Food & Drug Administration (free)

Commentary: Montelukast to Get Boxed Warning – NEJM Journal Watch (free)

Male and Female Physician Suicidality: A Systematic Review and Meta-analysis – JAMA Psychiatry (free for a limited period)

Editorial: Physician Suicide—A Personal and Community Tragedy (free for a limited period)

Commentary: Meta-Analysis Spotlights Challenge of Physician Suicide – Psychiatric New Alert (free)

Computerised cognitive training for 12 or more weeks for maintaining cognitive function in cognitively healthy people in late life – Cochrane Library (free)

Summary: Computerised cognitive training for maintaining cognitive function in cognitively healthy people in late life – Cochrane Library (free)

A novel digital intervention for actively reducing severity of paediatric ADHD (STARS-ADHD): a randomised controlled trial – The Lancet Digital Health (free)

Commentaries: Digital health interventions for children with ADHD – The Lancet Digital Health (free) AND Video game-like intervention shows promise in improving attention of children with ADHD – The Lancet (free)

Related Commentary on Twitter

There's something much better than Ritalin to help kids with attention-deficit hyperactivity disorder (#ADHD) and it's not a pill. It's a video game, validated in a randomized, controlled trialhttps://t.co/Xikx0fUNa4 @LancetDigitalH by @skollins1 @StephenFaraone and colleagues pic.twitter.com/AKn6F4rMUX

— Eric Topol (@EricTopol) February 25, 2020

Efficacy of new-generation antidepressants assessed with the Montgomery-Asberg Depression Rating Scale, the gold standard clinician rating scale: A meta-analysis of randomised placebo-controlled trials – PLOS One (free)

Related: Evidence Synthesis: Should Antidepressants be Used for Major Depressive Disorder? (free studies on the subject)

A Russian Prescription to Reduce Alcohol Use – Think Global Health (free)

Screening for Cognitive Impairment in Older Adults: US Preventive Services Task Force Recommendation Statement (free)

Evidence Report: Screening for Cognitive Impairment in Older Adults – US Preventive Services Task Force/JAMA (free)

Editorials: Issues and Questions Surrounding Screening for Cognitive Impairment in Older Patients – JAMA (free for a limited period) AND Evidence Still Lacking for Recommendation of Screening for Cognitive Impairment in Older Adults – JAMA Internal Medicine (free for a limited period)

Author Interview: USPSTF Recommendation: Screening for Cognitive Impairment (free audio)

JAMA Patient Page: Screening for Cognitive Impairment in Older Adults (free)

Commentary: U.S. Medical Panel Thinks Twice About Pushing Cognitive Screening For Dementia – Kaiser Health News (free)

Maternal and fetal outcomes following exposure to duloxetine in pregnancy: cohort study – The BMJ (free)

Individual Differences in Response to Antidepressants: A Meta-analysis of Placebo-Controlled Randomized Clinical Trials – JAMA Psychiatry (free for a limited period)

Editorial: Is This Where We Stand After Decades of Research to Develop More Personalized Treatments for Depression? (free for a limited period)

Commentary: How Variable are Patient Responses to Antidepressants? – MedPage Today (free registration required)

The Management of Chronic Insomnia Disorder and Obstructive Sleep Apnea: Synopsis of the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines – Annals of Internal Medicine (free)

Commentary: New VA/DoD guidelines address sleep-related issues in military personnel, veterans – University of Texas Health Science Center at San Antonio (free)

Cannabis use during pregnancy and postpartum – Canadian Family Physician (free)

Related: AAP Clinical Report: Implications of Marijuana Use During Pregnancy and Breastfeeding (free report and commentaries)

“There is no known safe level of cannabis use during pregnancy or lactation”

Use of Methylphenidate Analogues as Cognitive Enhancers: The Prelude to Cosmetic Neurology and an Ethical Issue – Frontiers in Psychiatry (free)

Related: Perspective: Use of ‘Smart Drugs’ on the Rise (several texts on the subject)

An electroencephalographic signature predicts antidepressant response in major depression – Nature Biotechnology (link to abstract – $ for full-text)

Commentaries: Neural signature identifies people likely to respond to antidepressant medication – NIH News Releases (free) AND Brain-wave pattern can identify people likely to respond to antidepressant, study finds – Stanford Medicine (free) AND AI, brain scans may alter how doctors treat depression – UT Southwestern Medical Center (free) AND Brain scans could be used to identify who will benefit from antidepressants – Business Insider (free) AND Resting-State EEG Can Predict Sertraline Treatment Outcomes – MPR (free) AND Will That Antidepressant Work For You? The Answer May Lie In Your Brain Waves – NPR (free)

Practice guideline: Treatment for insomnia and disrupted sleep behavior in children and adolescents with autism spectrum disorder – Neurology (free PDF)

Commentaries: Addressing Sleep Issues in Children, Teens With Autism – AJMC (free) AND Recommendations Issued for Sleep Disturbance in Pediatric Autism – Clinical Advisor (free)

Dietary Interventions for Autism Spectrum Disorder: A Meta-analysis – Pediatrics (free PDF)

Commentary: Dietary interventions have small effect on autism symptoms – 2 Minute Medicine (free)

Scrutinizing the effects of digital technology on mental health – Nature (free)

#194 Alcohol Use Disorder Treatment with Dr. Marlene Martin – The Curbsiders Internal Medicine Podcast (free)

See also: Episode List

Smartphones, social media use and youth mental health – Canadian Medical Association Journal (free)

News Release: Review of evidence finds excessive smartphone, social media use may be linked to youth mental health – Canadian Medical Association Journal (free)

Canadian practice guidelines for the treatment of children and adolescents with eating disorders – Journal of Eating Disorders (free)

Clarifying the Language of Clinician Distress – JAMA (free for a limited period)

Outcomes of Online Mindfulness-Based Cognitive Therapy for Patients With Residual Depressive Symptoms: A Randomized Clinical Trial – JAMA Psychiatry (free for a limited period)

Commentary: Researcher: New online therapy for lingering depression symptoms could fill ‘gap in care’ – University of Toronto (free)

FDA strengthens warning that untreated constipation caused by schizophrenia medicine clozapine (Clozaril) can lead to serious bowel problems – U.S. Food & Drug Administration (free)

See also: Clozaril, Fazaclo ODT, Versacloz (clozapine): Drug Safety Communication – FDA Strengthens Warning That Untreated Constipation Can Lead to Serious Bowel Problems – U.S. Food & Drug Administration (free)

Source: FDA Strengthens Constipation Warning on Clozapine – NEJM Journal Watch (free)

Society for Developmental and Behavioral Pediatrics Clinical Practice Guideline for the Assessment and Treatment of Children and Adolescents with Complex Attention-Deficit/Hyperactivity Disorder – Journal of Developmental & Behavioral Pediatrics (free PDF)

Commentary: New clinical practice guideline for complex ADHD in children and adolescents – Boston Children’s Hospital (free)

Related: AAP Guideline for the Diagnosis, Evaluation, and Treatment of ADHD in Children and Adolescents (free)

First-Trimester Pregnancy Exposure to Modafinil and Risk of Congenital Malformations – JAMA (free for a limited period)

Commentary: Modafinil in First Trimester Associated with Birth Defects – NEJM Journal Watch (free)

Recommendations of the Spanish Society of Paediatric Cardiology and Congenital Heart Disease as regards the use of drugs in attention deficit hyperactivity disorder in children and adolescents with a known heart disease, as well as in the general paediatric population: position statement by the Spanish Paediatric Association – Anales de Pediatría (free)

Related: AAP Guideline for the Diagnosis, Evaluation, and Treatment of ADHD in Children and Adolescents (free)

Optimal doses of antidepressants in dependence on age: Combined covariate actions in Bayesian network meta-analysis – EClinicalMedicine (free)

Related Meta-analysis: Optimal Dose of Antidepressants in Major Depression – The Lancet Psychiatry (free study and commentaries)

Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS): An update (2014–2018) – Clinical Neurophysiology (free)

No benefit from flexible titration above minimum licensed dose in prescribing antidepressants for major depression: systematic review – Acta Psychiatrica Scandinavica (link to abstract – $ for full-text)

Related Meta-analysis: Optimal Dose of Antidepressants in Major Depression – The Lancet Psychiatry (free study and commentaries)

Second-generation antipsychotics and pregnancy complications – European Journal of Clinical Pharmacology (free)

Effectiveness of mirtazapine as add-on to paroxetine v. paroxetine or mirtazapine monotherapy in patients with major depressive disorder with early non-response to paroxetine: a two-phase, multicentre, randomized, double-blind clinical trial – Psychological Medicine (link to abstract – $ for full-text)

Mental health issues and psychological factors in athletes: detection, management, effect on performance and prevention: American Medical Society for Sports Medicine Position Statement—Executive Summary – British Journal of Sports Medicine (free for a limited period)

Commentary: Sports Medicine Group Issues Guidance on Athletes’ Mental Health – Reuters / Medscape (free registration required)

Pharmacological interventions for treatment‐resistant depression in adults – Cochrane Library (free)

Summary: Are there effective medications for treating depression that does not improve with the first medication used? – Cochrane Library (free)

Nutritional psychiatry: Towards improving mental health by what you eat – European Neuropsychopharmacology (free)

Commentary: Diet and Mental Health: The Evidence to Date – Medscape (free registration required)

A network meta‐analysis of the effects of psychotherapies, pharmacotherapies and their combination in the treatment of adult depression – World Psychiatry (free)

Risk of Psychiatric Disorders and Suicide Attempts in Emerging Adults With Diabetes – Diabetes Care (link to abstract – $ for full-text)

Commentary: Suicide rates sharply higher than average in teens, young adults with diabetes – Reuters (free)

The use of antidepressants in oncology: a review and practical tips for oncologists – Annals of Oncology (free)

Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial – JAMA Psychiatry (free)

Editorial: The Potential Role of Lumateperone—Something Borrowed? Something New? – JAMA Psychiatry (free for a limited period)

Related Commentary on Twitter

In a Phase 3 trial, lumateperone (42mg) demonstrated significant efficacy for improving the symptoms of schizophrenia with a favorable safety profile. https://t.co/0eukuf1Qrf

— JAMA Psychiatry (@JAMAPsych) January 8, 2020

Patient safety in inpatient mental health settings: a systematic review – BMJ Open (free)

Beyond depression: Other uses for tricyclic antidepressants – Cleveland Clinic Journal of Medicine (free)

Dose-Response Meta-Analysis of Antipsychotic Drugs for Acute Schizophrenia – American Journal of Psychiatry (link to abstract – $ for full-text)

FDA warns about serious breathing problems with seizure and nerve pain medicines gabapentin (Neurontin, Gralise, Horizant) and pregabalin (Lyrica, Lyrica CR) – U.S Food & Drug Administration (free)

See also: Neurontin, Gralise, Horizant (gabapentin) and Lyrica, Lyrica CR (pregabalin): Drug Safety Communication – Serious Breathing Problems – U.S Food & Drug Administration (free)

Commentaries: Gabapentinoids Linked to Respiratory Problems in Certain Patients – NEJM Journal Watch (free) AND FDA warns gabapentin, pregabalin may cause serious breathing problems – The Hospitalist (free)

The Real Deal on Brain Health Supplements: GCBH Recommendations on Vitamins, Minerals, and Other Dietary Supplements – Global Council and Brain Health (free)

Commentary: AARP report: Insufficient evidence that dietary supplements benefit brain health – Science-Based Medicine (free)

Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis – The Lancet Psychiatry (free)

Commentaries: Insights into metabolic dysregulations associated with antipsychotics – The Lancet Psychiatry (free) AND Not all antipsychotics increase the risk of diabetes and raise cholesterol – some may be protective – The Conversation (free)

Comparison of Lemborexant With Placebo and Zolpidem Tartrate Extended Release for the Treatment of Older Adults With Insomnia Disorder: A Phase 3 Randomized Clinical Trial – JAMA Network Open (free)

Commentary: Insomnia: Lemborexant With Placebo Vs Zolpidem Tartrate Extended Release – MedicalResearch.com (free)

Identification, Evaluation, and Management of Children With Autism Spectrum Disorder – Pediatrics (free)

Commentaries: American Academy of Pediatrics Report Provides Sweeping Review of Evidence Concerning Autism Spectrum Disorder – American Academy of Pediatrics (free) AND Report: Pediatricians Should Be Ready to Screen Youngest Children for Autism – AJMC (free)

Prioritising action on alcohol for health and development – The BMJ (free)

See Complete Collection: Solutions for Prevention and Control of Non-communicable Diseases – WHO / The BMJ (free)

Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries) AND Alcohol Use and Burden for 195 Countries and Territories – The Lancet (free study and commentaries)

Prevalence of problematic smartphone usage and associated mental health outcomes amongst children and young people: a systematic review, meta-analysis and GRADE of the evidence – BMC Psychiatry (free)

Commentaries: An estimated 1 in 4 children and young people have problematic smartphone usage – King’s College London (free) AND Expert reaction to problematic smart phone use in young people – Science Media Centre (free) AND Teens aren’t addicted to their phones – but we like to think they are – NewScientist (free)

Association Between Physician Depressive Symptoms and Medical Errors: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentary: Depression in Docs Leads to Medical Errors and Vice Versa – Medscape (free registration required)

What You Need to Know (And What We’re Working to Find Out) About Products Containing Cannabis or Cannabis-derived Compounds, Including CBD – U.S. Food & Drug Administration (free)

Commentaries: FDA’s Warning On CBD: Cannabis Stocks Drop, Companies Object – Forbes (free) AND ‘CBD has the potential to harm you,’ FDA warns consumers – MarketWatch (free)

Related: Cannabidiol Products Are Everywhere, but Should People Be Using Them? – JAMA (free for a limited period) AND NICE Guideline: Cannabis-Based Medicinal Products (free Guideline and other resources)

#184 Update in Sleep Medicine: LIVE from CHEST 2019! – The Curbsiders Internal Medicine Podcast (free)

Long-term Outcomes of Cognitive Behavioral Therapy for Anxiety-Related Disorders: A Systematic Review and Meta-analysis – JAMA Psychiatry (free for a limited period)

Nutritional psychiatry: Towards improving mental health by what you eat – European Neuropsychopharmacology (free)

Guidelines on suicide amongst anaesthetists 2019 – Anaesthesia (free)

The mental health of PhD researchers demands urgent attention – Nature (free)

Related: PhDs: the tortuous truth – Nature’s survey of more than 6,000 graduate students reveals the turbulent nature of doctoral research – Nature (free)

Evaluation of Long-term Risk of Epilepsy, Psychiatric Disorders, and Mortality Among Children With Recurrent Febrile Seizures: A National Cohort Study in Denmark – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Risk of Epilepsy with Febrile Seizure – Journal Feed (free) AND Repeated febrile convulsions linked to epilepsy and psychiatric disorders – Aarhus University (free) AND Kids’ Fever-Related Convulsions Tied to Greater Risk of Epilepsy, Schizophrenia – PsychCentral (free)

Cannabidiol Products Are Everywhere, but Should People Be Using Them? – JAMA (free for a limited period)

Related: NICE Guideline: Cannabis-Based Medicinal Products (free Guideline and other resources)

Intensivist Burnout: Running on Empty? – CHEST (free)

Cannabis-based medicinal products – National Institute for Health and Care Excellence (free)

Commentaries: Drug experts on the new guidance for medicinal cannabis – The Conversation (free) AND Ian Hamilton: New guidelines for prescribing medicinal cannabis—another dashed hope for patients – The BMJ Opinion (free)

Related: Guideline for Prescribing Medical Cannabinoids in Primary Care – Canadian Family Physician (free) AND Cannabinoids for Chronic Pain – Therapeutics Initiative AND (free) Meta-Analysis: Insufficient Evidence for The Use of Cannabinoids for Treating Mental Disorders – The Lancet Psychiatry (link to abstract and commentaries) AND The Effects of Cannabis Among Adults With Chronic Pain – Annals of Internal Medicine (link to abstract and commentaries)

“In short, NICE has concluded that more research is needed before it can recommend the use of cannabis-based products for medicinal use.” (from The Conversation)

Sleep-Related Disorders in Neurology and Psychiatry – Deutsches Ärzteblatt international (free)

Hospital administration response to physician stress and burnout – Journal of Hospital Practice (free)

Source: Hospital Medicine Virtual Journal Club

Recent advances in therapies for eating disorders – F1000Research (free)

Related Guidelines: Eating disorders: recognition and treatment – NICE Guideline (free) AND Gynecologic Care for Adolescents and Young Women With Eating Disorders – American College of Obstetricians and Gynecologists (free)

Insomnia symptoms and risk of cardiovascular diseases among 0.5 million adults: A 10-year cohort – Neurology (free PDF)

Commentaries: Difficulty sleeping linked with raised risk of heart attack and stroke – NHS Choices (free) AND Insomnia in adults linked to heart attack and stroke – CNN (free) AND Insomnia maybe a significant risk factor for heart attacks and strokes – News Medical (free)

Associations Between Screen-Based Media Use and Brain White Matter Integrity in Preschool-Aged Children – JAMA Pediatrics (free for a limited period)

Commentaries: Expert reaction to study on screen use and white brain matter in children – Science Media Centre (free) AND Preschoolers’ Screen Time Tied to Brain Structure Irregularities – MedPage Today (free registration required)

Related: Meta-Analysis: Association Between Screen Media Use and Academic Performance Among Children and Adolescents (link to abstract and commentaries)

Short-Term Impact of a Flavored Tobacco Restriction: Changes in Youth Tobacco Use in a Massachusetts Community – American Journal of Preventive Medicine (free for a limited period)

Commentaries: Restricting flavored tobacco could curb youth use – Reuters (free) AND A tale of two cities: Impact of reducing teens’ access to flavored tobacco products – Elsevier (free) AND One town’s flavor ban seemed to work to cut youth tobacco use – CNN (free)

Related Opinion: Ban Flavored E-Cigarettes to Protect Our Children (free commentaries)

Mind-Body Therapies for Opioid-Treated Pain: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)

Commentaries: Study highlights role of mind-body therapies in addressing opioid-treated pain – News Medical (free) AND Meditation, Mindfulness Hold Promise for Pain Treatment, Curbing Opioid Use – U.S. News (free)

Omega-3 and polyunsaturated fat for prevention of depression and anxiety symptoms: systematic review and meta-analysis of randomised trials – British Journal of Psychiatry (link to abstract – $ for full-text)

News Release: Fish oil supplements have no effect on anxiety and depression – University of East Anglia (free)

Emerging Applications for Ketamine – JAMA (free audio)

Related Resources:

Ketamine for Pain: Consensus Guidelines on the Use of Intravenous Ketamine Infusions for Acute Pain Management From the American Society of Regional Anesthesia and Pain Medicine, the American Academy of Pain Medicine, and the American Society of Anesthesiologists (free)

Ketamine for Depression: Ketamine and depression: a narrative review – Drug Design, Development and Therapy (free)

Mental Health Competencies for Pediatric Practice – Pediatrics (free)

Technical Report: Achieving the Pediatric Mental Health Competencies – Pediatrics (free)

News Release: American Academy of Pediatrics Provides Guidance on Helping Children With Mental Health Challenges – American Academy of Pediatrics (free)

Interventions for prodromal stage of psychosis – Cochrane Library (free)

Summary: Early interventions for people at risk of developing psychosis – Cochrane Library (free)

Schizophrenia—An Overview – JAMA Psychiatry (free for a limited period)

Association of Cord Plasma Biomarkers of In Utero Acetaminophen Exposure With Risk of Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder in Childhood – JAMA Psychiatry (free for a limited period)

Commentaries: NIH-funded study suggests acetaminophen exposure in pregnancy linked to higher risk of ADHD, autism – NIH News Releases (free) AND Babies at higher risk for ADHD, autism if pregnant moms took acetaminophen – Reuters (free) AND Expert reaction to study looking at paracetamol in pregnancy and autism, ADHD and other developmental disabilities in children – Science Media Centre (free)

Related Studies: Cohort Study: Associations Between Paracetamol Intake Between 18 and 32 Weeks Gestation and Neurocognitive Outcomes in the Child (free) AND Meta-Analysis: Prenatal Exposure to Acetaminophen and Risk for ADHD and Autistic Spectrum Disorder (free) AND Prenatal Exposure to Acetaminophen and Risk of ADHD (free)

Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials – Journal of Neurology, Neurosurgery & Psychiatry (free)

Commentaries: Expert reaction to systematic review and meta-analysis of RCTs on anti-inflammatory drugs for depression – Science Media Centre (free) AND Anti-inflammatories can curb major depressive symptoms – OnMedica (free) AND Anti-inflammatory agents can effectively and safely curb major depressive symptoms, study suggests – BMJ (free)

It’s time to talk about physician burnout and moral injury – The Lancet Psychiatry (free)

Related: Moral Injury and Burnout in Medicine: A Year of Lessons Learned (free Commentaries) AND Consensus Study – Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being (free)

Discrimination, Abuse, Harassment, and Burnout in Surgical Residency Training – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Women surgical residents suffer more mistreatment leading to burnout and suicidal thoughts – University of Northwestern (free) AND Harassment and Discrimination Are Leading to Burnout Among Female Doctors, Study Says – TIME (free)

A comprehensive analysis of mortality-related health metrics associated with mental disorders: a nationwide, register-based cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Life expectancy mapped for people with mental disorders – The University of Queensland (free) AND Mentally ill die many years earlier than others – Aarhus University (free)

Related Commentary on Twitter (Thread – Click for More)

Our paper published in @TheLancet: A large population-based cohort study to investigate a range of mortality-related health metrics associated with mental disorders
👉 https://t.co/4PZbUpQggM

Thread with results, webpage, open access version… 👇 #EpiTwitter @John_J_McGrath pic.twitter.com/HcX8HXSyqg

— Oleguer Plana-Ripoll (@oleguerplana) October 24, 2019

Cannabinoids for the treatment of mental disorders and symptoms of mental disorders: a systematic review and meta-analysis – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Marijuana Cannabinoids Don’t Help With Depression, Anxiety, ADHS, Tourettes, Psychosis, Or PTSD – Scientific Blogging (free) AND There is little evidence that cannabis helps mental health problems – NewScientist (free) AND There’s ‘Scarce Evidence’ to Suggest Cannabis Improves Mental Health Symptoms, a New Research Review Says – TIME (free) AND Medicinal cannabis not proven in mental health, study finds – Reuters (free) AND Risks of cannabis use for mental health treatment outweigh benefits – The Guardian (free)

Related Commentary on Twitter

NEW—Insufficient evidence that medicinal #cannabinoids improve #mentalhealth: finding from a systematic review and meta-analysis combining 83 studies including 3000 people @TheLancetPsych https://t.co/dD7czOHA7O pic.twitter.com/tvsDCqcnfa

— The Lancet (@TheLancet) October 28, 2019

Cognitive deficits in problematic internet use: meta-analysis of 40 studies – British Journal of Psychiatry (free)

Commentary: Too much of a good thing: the cognitive impact of problematic internet use – The Mental Elf (free)

Homepage: Drug Use – The Lancet (free articles, commentaries, and podcast – registration required)

Psychiatric morbidity and suicidal behaviour in low- and middle-income countries: A systematic review and meta-analysis – PLOS Medicine (free)

Commentary: Suicide and mental illness in low- and middle-income countries – The Mental Elf (free)

What causes us to burnout at work? – World Economic Forum (free)

Related: WHO Redefines Burnout As A ‘Syndrome’ Linked To Chronic Stress At Work (free)

Homepage: Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being – National Academies of Medicine (free resources)

Full Report: Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being (free PDF – registration required)

Commentary: Improving the System to Support Clinician Well-being and Provide Better Patient Care – JAMA (free for a limited period)

Author Interview: Improving the System to Support Clinician Well-being and Provide Better Patient Care (free audio)

See also: Report Highlights | Key Messages | Report Recommendations | Press Release | Report Release Slides | Social Media Toolkit

Effect of Fluoxetine on Obsessive-Compulsive Behaviors in Children and Adolescents With Autism Spectrum Disorders: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentaries: Study finds little evidence on effectiveness of common antidepressant in autism spectrum disorders – News Medical (free) AND Prozac proves no better than a placebo in treating kids with autism – ScienceNews (free)

Stress related disorders and subsequent risk of life threatening infections: population based sibling controlled cohort study – The BMJ (free)

Editorial: Stress related disorders and physical health (free)

Commentary: Stress-related disorders linked to subsequent risk of severe infections – British Medical Journal (free)

Social media use and adolescent sleep patterns: cross-sectional findings from the UK millennium cohort study – BMJ Open (free)

Commentaries: More LOLs, Fewer Zzzs: Teens May Be Losing Sleep Over Social Media – NPR (free) AND High social media use linked to poor sleep in teens – OnMedica (free) AND Heavy social media use linked to poor sleep – BBC (free)

Risk of Developing Parkinson Disease in Bipolar Disorder: A Systematic Review and Meta-analysis – JAMA Neurology (free for a limited period)

Commentaries: Patients With Bipolar Disorder More Than 3 Times as Likely to Develop PD – AJMC (free) AND Looking for links between Parkinson’s and bipolar disorder – Medical News Today (free) AND Parkinson’s And Bipolar Disorder: Is There A Link Between The Two? – Medical Daily (free) AND Bipolar Disorder Raises Subsequent Risk of Parkinson’s – MedPage Today (free registration required)

Lithium Exposure During Pregnancy and the Postpartum Period: A Systematic Review and Meta-Analysis of Safety and Efficacy Outcomes – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Prescribing Lithium During Pregnancy Requires Careful Balancing of Benefits, Risks – Psychiatric News Alert (free)

Treating restless legs syndrome in the context of sleep disordered breathing comorbidity – European Respiratory Review (free)

Effect of Depression Screening After Acute Coronary Syndromes on Quality of Life: The CODIACS-QoL Randomized Clinical Trial – JAMA Internal Medicine (free for a limited Period)

Commentary: Depression Intervention Flops for Heart Attack Survivors – MedPage Today (free registration required)

Mental health outcomes associated with of the use of amphetamines: A systematic review and meta-analysis – EClinicalMedicine (free)

Death Rates Due to Suicide and Homicide Among Persons Aged 10–24: United States, 2000–2017 – Centers for Disease Control and Prevention (free)

Commentary: Suicide Among Young People Climbs 56% in 10 Years – NEJM Journal Watch (free)

Using the 9-Item Patient Health Questionnaire to Screen for and Monitor Depression – JAMA (free for a limited period)

The Hyperactivity–Impulsivity–Irritiability–Disinhibition–Aggression–Agitation Domain in Alzheimer’s Disease: Current Management and Future Directions – Frontiers in Pharmacology (free)

Association Between Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Suicide – JAMA Network Open (free)

Commentaries: Concerns Raised by a Study of Suicide as an Adverse Drug Effect—Replicating Findings From Real-World Data – JAMA Network Open (free) AND Expert reaction to study looking at ACE inhibitor blood pressure drugs, angiotensin receptor blockers (ARBs) blood pressure drugs, and risk of suicide – Science Media Centre (free) AND Certain Blood Pressure Meds Tied to Suicide Risk in Study – HealthDay News (free)

Moderation of neural excitation promotes longevity – Nature News (free)

Original Article: Regulation of lifespan by neural excitation and REST – Nature (link to abstract – $ for full-text)

See also: Here’s a brain teaser: Surprising study shows reduced neuronal activity extends life – STAT (free) AND In a first, scientists pinpoint neural activity’s role in human longevity – Harvard Medical School (free)

Comparative Efficacy of Interventions for Aggressive and Agitated Behaviors in Dementia: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Non-pharmacologic treatments may be more effective for psychiatric symptoms of dementia – St. Michael’s Hospital (free) AND To ease dementia agitation, drugs may not be best option – Reuters (free)

Valproate for acute mania – Cochrane Library (free)

Summary: Valproate for acute mania  – Cochrane Library (free)

Related Commentary on Twitter

Valproate for acute mania https://t.co/TkYwwe64Gs Updated review from @Cochrane_CCMD Valproate is an effective antimanic treatment. Valproate may be inferior to olanzapine in adults. Valproate may be inferior to risperidone in acute mania in paediatric and adolescent populations. pic.twitter.com/eHN9dTcIzo

— Cochrane UK (@CochraneUK) October 12, 2019

HHS Guide for Clinicians on the Appropriate Dosage Reduction or Discontinuation of Long-Term Opioid Analgesics – U.S. Department of Health and Human Services (free)

News Release: HHS Announces Guide for Appropriate Tapering or Discontinuation of Long-Term Opioid Use – U.S. Department of Health and Human Services (free) AND

Commentaries: Patient-Centered Reduction or Discontinuation of Long-term Opioid Analgesics: The HHS Guide for Clinicians – JAMA (free for a limited period) AND With a new guide to tapering opioids, federal health officials seek a balanced approach to prescribing – STAT (free) AND Don’t Force Patients Off Opioids Abruptly, New Guidelines Say, Warning Of Severe Risks – NPR (free)

Author Interview: The HHS Guide to Patient-Centered Dose Reduction or Discontinuation of Long-term Opioids – JAMA (free)

Related: Pain Management With Opioids in 2019-2020 – JAMA (free registration required)

A brief diet intervention can reduce symptoms of depression in young adults – A randomised controlled trial – PLOS Medicine (free)

Commentaries: Changing Your Diet Can Help Tamp Down Depression, Boost Mood – NPR (free) AND Randomized Controlled Trial in Young Adults Suggests Healthier Diet May Directly Reduce Depression – PLOS (free)

Advice to Young Psychiatrists From a Very Old One – Psychiatric Times (free)

Draft Recommendation Statement: Illicit Drug Use in Children, Adolescents, and Young Adults: Primary Care–Based Interventions – U.S. Preventive Services Task Force (free)

Alcohol Consumption and Risk of Dementia and Cognitive Decline Among Older Adults With or Without Mild Cognitive Impairment – JAMA Network Open (free)

Commentaries: Alcohol and dementia risk: A complex relationship – Medical News Today (free) AND Alcohol Consumption May Increase Dementia Risk in Older Adults – Psychiatric News Alert (free) AND Expert reaction to study looking at alcohol and risk of dementia and cognitive decline – Science Media Centre (free)

Association of Use of Oral Contraceptives With Depressive Symptoms Among Adolescents and Young Women – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Teens taking oral contraceptives may be at increased risk for depressive symptoms – Brigham and Women’s Hospital (free) AND Teen OC Users More Likely to Report Depressive Symptoms – NEJM (free)

Antidepressant use during pregnancy and the risk of gestational diabetes mellitus: a nested case–control study – BMJ Open (free)

Commentaries: Antidepressants linked to heightened pregnancy related diabetes risk – BMJ (free) AND Antidepressants linked to risk of gestational diabetes – OnMedica (free) AND Antidepressants are linked to a higher gestational diabetes risk in a new study – CNN (free)

Association of Antidepressant Use With Adverse Health Outcomes: A Systematic Umbrella Review – JAMA Psychiatry (free for a limited period)

Editorial: Selective Serotonin Reuptake Inhibitor Use During Pregnancy—Associated With but Not Causative of Autism in Offspring (free for a limited period)

Commentaries: Antidepressant medications appear to be generally safe,study suggests – Linköping University (free) AND Expert reaction to study on association of antidepressant use with adverse health outcomes – Science Media Centre (free)

Long-term outcomes of childhood sexual abuse: an umbrella review – The Lancet Psychiatry (free)

Commentaries: Understanding and responding to the long-term burdens of childhood sexual abuse – The Lancet Psychiatry (free) AND Childhood sexual abuse linked to a range of physical and mental health conditions – University of Oxford (free)

Clinical Practice Guideline for the Diagnosis, Evaluation, and Treatment of Attention-Deficit/Hyperactivity Disorder in Children and Adolescents – Pediatrics (free)

News Release: Updated ADHD guideline addresses evaluation, diagnosis, treatment from ages 4-18 – American Academy of Pediatrics (free)

Commentary: Pediatricians Stand By Meds For ADHD, But Some Say Therapy Should Come First – NPR (free)

Incidence and Determinants of Mental Health Service Use After Bariatric Surgery – JAMA Psychiatry (free for a limited period)

Commentaries: Patients more likely to seek psychiatric help after weight-loss surgery – Reuters (free) AND Mental health service use up after bariatric surgery – MedicalXpress (free)

Suicide Prevention Strategies for General Hospital and Psychiatric Inpatients: A Narrative Review – Indian Journal of Psychological Medicine (free)

Related Review: Preventing Suicide Among Inpatients – Canadian Journal of Psychiatry (free)

News Release: First large-scale study of universal screening for autism raises questions about accuracy – Children’s Hospital of Philadelphia (free)

Original Study: Accuracy of Autism Screening in a Large Pediatric Network – Pediatrics (free)

Should antidepressants be used for major depressive disorder? – BMJ Evidence-Based Medicine (free)

Related Meta-analysis: Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis – The Lancet (free)

Related Commentary: Do Antidepressants Work? – The New York Times (10 articles per month are free)

“Generally, all the previous reviews show that antidepressants seem to have statistically significant effects on depressive symptoms, but the size of the effect has questionable importance to most patients.”

Injectable opioid agonist treatment for opioid use disorder: a national clinical guideline – Canadian Medical Association Journal (free)

Commentaries: First-of-its-kind guideline sets out best practices for delivering injectable opioid agonist treatment – The University of British Columbia (free) AND New national guideline sets out best practices for delivering injectable opioid agonist treatment – Canadian Medical Association Journal (free)

School-aged Children Who Are Not Progressing Academically: Considerations for Pediatricians – Pediatrics (free)

News Release: Report guides pediatricians in evaluating children with academic problems – American Academy of Pediatrics (free)

Commentary: Pediatrics Group Offers Guidance for Supporting Children who Struggle in School – NEJM Journal Watch (free)

Association of Relative Age in the School Year With Diagnosis of Intellectual Disability, Attention-Deficit/Hyperactivity Disorder, and Depression – JAMA Pediatrics (free)

Commentaries: Youngest children in school year could be at higher risk of mental health problems – London School of Hygiene & Tropical Medicine (free) AND Expert reaction to relative age in school year, and diagnosis of intellectual disability, depression and ADHD – Science Media Centre (free)

Related: Study: Youngest in Class More Likely to be Diagnosed with ADHD (link to abstract and commentaries) AND Systematic Review: Youngest in Class More Likely to be Diagnosed with ADHD (free study and commentaries)

Association Between Screen Media Use and Academic Performance Among Children and Adolescents: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)

Commentaries: Expert reaction to screen media use and academic performance – Science Media Centre (free) AND Not all screen time causes kids to underperform in school, study says – CNN (free)

The clinical effectiveness of sertraline in primary care and the role of depression severity and duration (PANDA): a pragmatic, double-blind, placebo-controlled randomised trial – The Lancet Psychiatry (free)

Commentaries: Examining the antidepressant scattergun approach – The Lancet Psychiatry (free) AND Expert reaction to study on the clinical effectiveness of the antidepressant sertraline – Science Media Centre (free) AND Common antidepressant more effective for anxiety than depression – UPI (free) AND Antidepressants work, but just not how scientists thought they worked – The Conversation (free) AND Antidepressants may reduce anxiety more than depressive symptoms – University College London (free)

Related Commentary on Twitter (Thread – click for more)

Important new trial on the real-world effectiveness of antidepressants (sertraline) in primary care patients. Main finding: There is no evidence that antidepressants effectively treat depression symptoms in real-world patients (effect size: d<0.2) https://t.co/bq9atTwrdo

— Michael P. Hengartner, PhD (@HengartnerMP) September 20, 2019

Nicotine patches used in combination with e-cigarettes (with and without nicotine) for smoking cessation: a pragmatic, randomised trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Commentary: Quick Take: Nicotine patches used in combination with e-cigarettes (with and without nicotine) for smoking cessation – 2 Minute Medicine (free)

Related: It’s safest to avoid e-cigarettes altogether – unless vaping is helping you quit smoking – The Conversation (free)

Related Commentary on Twitter

Pragmatic RCT (n=1124) finds combining #nicotinepatches with nicotine #ecigarettes -> higher abstinence rates at 6 months (measured using exhaled CO levels) compared with patches + nicotine-free e-cigarettes, or patches alone (7% vs 4% vs 2% respectively)https://t.co/QUfLln1eBv

— ⚖️Health Evidence Matters💡 (@HealthEvMatters) September 12, 2019

Mental health apps are scooping up your most sensitive data. Will you benefit? – STAT (free)

Ritalin at 75: what does the future hold? – The Conversation (free)

Medication-Assisted Treatment for Opioid-Use Disorder – Mayo Clinic Proceedings (free for a limited period)

“It’s All in Your Head”—Medicine’s Silent Epidemic – JAMA Neurology (free for a limited period)

Ketamine and depression: a narrative review – Drug Design, Development and Therapy (free)

Related Systematic Review: Ketamine and other glutamate receptor modulators for depression in adults – Cochrane Library (free)

Associations between paracetamol (acetaminophen) intake between 18 and 32 weeks gestation and neurocognitive outcomes in the child: A longitudinal cohort study – Pediatric and Perinatal Epidemiology (free)

Commentaries: Taking paracetamol during pregnancy may affect the child’s behaviour in early years – The Conversation (free) AND Expert reaction to study looking at paracetamol in pregnancy and behaviour, memory and IQ in children – Science Media Centre (free) AND Paracetamol in pregnancy linked to behaviour problems in children – OnMedica (free)

Related: Meta-Analysis: Prenatal Exposure to Acetaminophen and Risk for ADHD and Autistic Spectrum Disorder (free)

Association Between Antipsychotic Medication Use and Diabetes – Current Diabetes Reports (free)

Depression and Suicidality in Multiple Sclerosis: Red Flags, Management Strategies, and Ethical Considerations – Current Neurology and Neuroscience Reports (free)

Associations Between Time Spent Using Social Media and Internalizing and Externalizing Problems Among US Youth – JAMA Psychiatry (link to abstract – $ for full-text)

Author Interview: Associations Between Social Media Time and Internalizing and Externalizing Problems Among US Youth (free audio)

Commentaries: Social Media Use by Adolescents Linked to Internalizing Behaviors – Johns Hopkins Bloomberg School of Public Health (free) AND More Social Media Use Linked to More Depression and Anxiety in Teens – NEJM Journal Watch (free) AND Expert reaction to study looking at social media and adolescent mental health – Science Media Centre (free)

Related: Association of Screen Time and Depression in Adolescence (links to abstract and commentaries) AND The Adverse Effects of Social Media use on Young People’s Mental Health May be Caused by Exposure to Cyberbullying, Loss of Sleep, and Reduced Physical Activity (links to abstract and commentaries) AND Research: This Is Your Brain Off Facebook (free) AND Cohort Study: Social Media Use and Adolescent Mental Health (free) AND Supplement: Children, Adolescents and Screens: What We Know and What We Need To Learn (free articles)

How many premature deaths from pesticide suicide have occurred since the agricultural Green Revolution? – Clinical Toxicology (free)

Commentaries: Scale of suicides by pesticide poisoning revealed – University of Edinburgh (free) AND 15 million people worldwide may have died by suicide with pesticides – UPI (free)

Related: Suicide in the World: WHO Global Health Estimates (free report and commentaries) AND Preventing Suicide: A resource for pesticide registrars and regulators – World Health Organization (free PDF)

The Effectiveness of Selective Serotonin Reuptake Inhibitors for Treatment of Obsessive-Compulsive Disorder in Adolescents and Children: A Systematic Review and Meta-Analysis – Frontiers in Psychiatry (free)

Suicide in the World: Global Health Estimates – World Health Organization (free PDF)

News Release: Suicide: one person dies every 40 seconds – World Health Organization (free)

Commentaries: One person dies by suicide every 40 seconds: new UN health agency report – UN News (free) Suicide kills one person every 40 seconds, says WHO – Reuters (free) AND One person dies every 40 seconds from suicide, WHO says – CNN (free)

The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice – International Journal of Molecular Sciences (free)

Related Reviews: Serotonin syndrome: Preventing, recognizing, and treating it – Cleveland Clinic Journal of Medicine (free) AND Demystifying serotonin syndrome (or serotonin toxicity) – Canadian Family Physician (free)

The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution) – Forbes (free)

Related: Physician Burnout: A Global Crisis (several resources on the subject)

Medical education needs to stop burning out students — now – STAT (free)

Related: Meta-analysis: The Global Prevalence of Anxiety Among Medical Students (free studies)

Clinical guidelines for the management of treatment-resistant depression: French recommendations from experts, the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental – BMC Psychiatry (free)

Related Guidelines: Clinical guidelines for the management of depression with specific comorbid psychiatric conditions French recommendations from experts (the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental) – BMC Psychiatry (free) AND Depression in adults: recognition and management – National Institute for Health and Care Excellence (free)

Association of Cesarean Delivery With Risk of Neurodevelopmental and Psychiatric Disorders in the Offspring: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: There’s no evidence caesarean sections cause autism or ADHD – The Conversation (free) AND Expert reaction to study on caesareans and neurodevelopmental disorders – Science Media Centre (free)

Diagnosis and treatment of acute alcohol intoxication and alcohol withdrawal syndrome: position paper of the Italian Society on Alcohol – Internal and Emergency Medicine (free PDF)

Assessment and Management of Patients at Risk for Suicide: Synopsis of the 2019 U.S. Department of Veterans Affairs and U.S. Department of Defense Clinical Practice Guidelines – Annals of Internal Medicine (free)

Related Guidelines: Preventing suicide: A community engagement toolkit – World Health Organization (free PDF) AND Preventing suicide in community and custodial settings – National Institute for Health and Care Excellence (free)

Treatments for the Prevention and Management of Suicide: A Systematic Review – Annals of Internal Medicine (free)

Association of Restless Legs Syndrome With Risk of Suicide and Self-harm – JAMA Network Open (free)

Commentaries: Suicide risk nearly three times as high for those with restless legs syndrome – UPI (free) AND Restless Legs Syndrome Linked to Increased Risk for Self-Harm or Suicide – NEJM Journal Watch (free)

A Review on Strategies to Manage Physician Burnout – Cureus (free)

Related: Physician Burnout: A Global Crisis (several resources on the subject)

Source: Hospital Medicine Virtual Journal Club

Bipolar depression: the clinical characteristics and unmet needs of a complex disorder – Current Medical Research and Opinion (free)

Related: Bipolar disorder: assessment and management – National Institute for Health and Care Excellence (free) AND Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) 2018 guidelines for the management of patients with bipolar disorder – Bipolar Disorders (free) AND Systematic Review: Treatment for Bipolar Disorder in Adults – Agency for Healthcare Research and Quality (free)

Effect of Continuing Olanzapine vs Placebo on Relapse Among Patients With Psychotic Depression in Remission: The STOP-PD II Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Maintenance Treatment for Psychotic Depressive Disorders: Progress and Remaining Challenges (free for a limited period)

The Global Prevalence of Anxiety Among Medical Students: A Meta-Analysis – International Journal of Environmental Research and Public Health (free)

Related: Medical student wellbeing – a consensus statement from Australia and New Zealand – BMC Medical Education (free) AND Prevalence of Depression, Depressive Symptoms, and Suicidal Ideation Among Medical Students: A Systematic Review and Meta-Analysis – JAMA (free)

Association Between Electronic Cigarette Use and Marijuana Use Among Adolescents and Young Adults: A Systematic Review and Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: Youth Who Use E-Cigarettes May Be More Likely to Use Marijuana, Study Finds – Psychiatric News Alert (free) AND Teens who vape three times more likely to use marijuana – UPI (free) AND Vaping linked to marijuana use in young people, research says – CNN (free)

Draft Recommendation Statement: Screening for Illicit Drug Use, Including Nonmedical Use of Prescription Drugs: Screening – U.S. Preventive Services Task Force (free)

Commentaries: For the first time, U.S. panel recommends screening adults for illicit drug use – STAT (free) AND Screen All Adult Patients for Drug Abuse, National Panel Urges – The New York Times (10 articles per month are free) AND

Roles of cyberbullying, sleep, and physical activity in mediating the effects of social media use on mental health and wellbeing among young people in England: a secondary analysis of longitudinal data – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentaries: Social media use may harm teens’ mental health by disrupting positive activities, study says – CNN (free) AND Social-media use ‘disrupting teen sleep and exercise’ – BBC (free) Expert reaction to study on social media use and the role of cyberbullying, sleep and physical activity in the wellbeing in young people – Science Media Centre (free) AND Social Media’s Ill Effects in Teen Girls: 3 Factors Play Large Role – NEJM Journal Watch (free)

Related Commentary on Twitter

New study suggests that #SocialMedia itself doesn't cause harm to #adolescents, but #MentalHealth harms related to very frequent use in girls might be due to exposure to #cyberbullying, loss of sleep, or reduced physical activity. https://t.co/CGt63GnW7J @russellviner pic.twitter.com/J7SuMORjLj

— The Lancet Child & Adolescent Health (@LancetChildAdol) August 13, 2019

Public Health Policies and Alcohol-related Liver Disease – JHEP Reports (free)

Related: Treating alcohol-related liver disease from a public health perspective – Journal of Hepatology (free) AND WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries) AND Alcohol Use and Burden for 195 Countries and Territories – The Lancet (free study and commentaries)

The Role of Exercise in Preventing and Treating Depression – Current Sports Medicine Reports (free)

News Release: ‘Exercise as Medicine’ for Depression – A Key But Often Overlooked Role In Prevention And Treatment – Wolters Kluwer Health (free)

Related Meta-Analysis: Physical Activity and Incident Depression (free study and commentaries) AND Resistance Exercise for Depressive Symptoms (free study and commentaries) AND Aerobic Exercise for Adult Patients with Major Depressive Disorder (free study and commentaries)

Alcohol Use in Pregnancy and Miscarriage: A Systematic Review and Meta‐Analysis – Alcoholism: Clinical and Experimental Research (free PDF)

Commentary: Alcohol exposure during pregnancy linked with dose-dependent increase in miscarriage risk – News Medical (free)

Evaluation of spin in abstracts of papers in psychiatry and psychology journals – BMJ Evidence-Based Medicine (free)

Commentaries: Expert reaction to study reporting ‘spin’ in abstracts of psychiatry and psychology journals – Science Media Centre (free) AND ‘Spin’ found in over half of clinical trial abstracts published in top psychiatry journals – The British Medical Journal (free)

Related: Systematic Review: Spin in Published Cardiovascular Randomized Trials with Statistically Nonsignificant Primary Outcomes (free study and editorial) AND ‘Spin’ in published biomedical literature: A methodological systematic review – PLOS Biology (free)

If You Smoke Pot, Your Anesthesiologist Needs To Know – Kaiser Health News (free)

Related: Perioperative care of cannabis users: A comprehensive review of pharmacological and anesthetic considerations – Journal of Clinical Anesthesia (free)

“One small study of Colorado patients published in May found marijuana users required more than triple the amount of one common sedation medicine, propofol, as did nonusers.”

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Psychotherapy should be first-line treatment for depression in young people, trial finds – by Orygen, the National Centre of Excellence in Youth Mental Health (free) AND Psychotherapy should be first option to treat depression in young people, study says – UPI (free)

Generalised anxiety disorder and panic disorder in adults: management – National Institute for Health and Care Excellence (free)

Related Guideline: Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder (free)

Pharmacologic Management of Agitation in Patients with Dementia – Current Geriatrics Reports (free)

Related: Nonpharmacological Interventions to Reduce Behavioral and Psychological Symptoms of Dementia: A Systematic Review – BioMed Research International (free) AND Systematic review of systematic reviews of non-pharmacological interventions to treat behavioural disturbances in older patients with dementia. The SENATOR-OnTop series – BMJ Open (free)

Mounting Evidence and Netflix’s Decision to Pull a Controversial Suicide Scene – JAMA (free for a limited period)

Related: Release of “13 Reasons Why” Associated with Increase in Youth Suicide Rates (link to abstract and commentaries)

Clinical use of lithium salts: guide for users and prescribers – International Journal of Bipolar Disorders (free)

Prevalence of obstructive sleep apnea in suicidal patients with major depressive disorder – Journal of Psychiatric Research (link to abstract – $ for full-text)

Commentary: Obstructive sleep apnea may be one reason depression treatment doesn’t work – Medical College of Georgia at Augusta University (free)

Association of Genetic and Environmental Factors With Autism in a 5-Country Cohort – JAMA Psychiatry (free for a limited period)

Editorial: The Architecture of Autism Spectrum Disorder Risk: What Do We Know, and Where Do We Go From Here? (free)

Commentaries: Genetic factors are primary cause of autism, study finds – UPI (free) AND Study provides ‘strongest evidence’ yet for autism being a genetic condition – News Medical (free) AND A new study reinforces the conclusion that autism is primarily genetic – Science Based Medicine (free)

Efficacy of Short-term Treatment of Internet and Computer Game Addiction: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Author Interview: Efficacy of Short-term Treatment of Internet and Computer Game Addiction (free audio)

Commentaries: CBT Program Reduces Addictive Internet Behaviors in Men, Study Finds – Psychiatric News Alert (free) AND Does Short-term Treatment of Internet and Computer Game Addiction Work? – MedicalResearch.com (free) AND Addicted to the internet? Behavioral therapy could work, researchers find – CNN (free)

Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentaries: Study Distinguishes Schizophrenia Drug Effects Among Patients – MD Magazine (free) AND New Guidance on Antipsychotic Choice – Medscape (free registration required)

“These findings will aid clinicians in balancing risks versus benefits of those drugs available in their countries. They should consider the importance of each outcome, the patients’ medical problems, and preferences.”

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness – The Lancet Psychiatry (free registration required)

Executive Summary and Podcast: A blueprint for protecting physical health in people with mental illness (free summary, audio and other resources)

Commentaries: Global commission into health inequities of mental illness gives blueprint for change – NICM Health Research Institute at Western Sydney University (free) AND People with mental illness experience poorer physical health, and the gap may be getting worse, experts say – ABC News (free) AND Why people with mental illness may face poorer physical health and early death – CNN (free)

Related WHO Guideline: Management of Physical Health Conditions in Adults with Severe Mental Disorders (free)

Related Commentary on Twitter (Thread – Click for More)

Our new @TheLancetPsych Commission #BlueprintMPH tackles the growing health inequalities associated with mental illness – presenting a 'blueprint for protecting physical Health in people with mental illness" https://t.co/l6P3owTnq9 across 5 different Parts, as follows (thread): pic.twitter.com/lCiKvQbzQK

— Joseph Firth (@joefirth7) July 16, 2019

Lithium as the drug of choice for maintenance treatment in bipolar disorder – Acta Psychiatrica Scandinavica (free) (via @J_F_Hayes)

Original Article: A systematic review and meta‐analysis of clinical predictors of lithium response in bipolar disorder – Acta Psychiatrica Scandinavica (free)

Post‐intensive care syndrome: its pathophysiology, prevention, and future directions – Acute Medicine & Surgery (free) (via @NydahlPeter)

Related Reviews: Post-intensive care outpatient clinic: is it feasible and effective? A literature review – Revista Brasileira de Medicina Intensiva (free) AND Post-intensive Care Syndrome: an Overview – Journal of Translational Internal Medicine (free) AND Optimizing Post-Intensive Care Unit Rehabilitation – Turkish Thoracic Journal (free)

Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing – Korean Journal of Family Medicine (free PDF)

“individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.”

Association of Screen Time and Depression in Adolescence – JAMA Pediatrics (free for a limited period)

Commentaries: Expert reaction to a study on screen time and depression in adolescents – Science Media Centre (free) AND Increasing social media use tied to rise in teens’ depressive symptoms, study says – CNN (free)

Editorial: Physician burnout: a global crisis – The Lancet (free)

Related Perspectives: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free) AND The Burnout Crisis in American Medicine – The Atlantic (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record – Harvard Business Review (free commentaries) AND Physician burnout costs up to $17B a year, task force says – HealthcareDive (free)

Related Articles: Systematic Review: Prevalence of Burnout Among Physicians (free) AND Burnout syndrome among medical residents: A systematic review and meta-analysis – PLOS One (free) AND Prevalence of Burnout in Medical and Surgical Residents: A Meta-Analysis – International Journal of Environmental Research and Public Health (free) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and commentaries) AND Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction (link to abstract and commentaries)

Neuropsychiatric Sequelae in Adolescents With Acute Synthetic Cannabinoid Toxicity – Pediatrics (link to abstract – $ for full-text)

News Release: Study: Seizures, coma more common with synthetic cannabinoids than cannabis – American Academy of Pediatrics (free)

Commentary: Synthetic Cannabinoids Associated with More Comas and Seizures in Teens – NEJM Journal Watch (free)

Change in moderate alcohol consumption and quality of life: evidence from 2 population-based cohorts – Canadian Medical Association Journal (free)

Commentaries: Drinking less might be tied to higher quality of life – Reuters (free) AND Women’s mental health may improve after quitting alcohol – UPI (free) AND Quitting alcohol may improve mental well-being, health-related quality of life – EurekAlert (free)

Related Commentary on Twitter

Quitting alcohol may improve health-related quality of life for women, especially their mental well-being, according to a study by Dr. Xiaoxin Yao and colleagues published in CMAJ: https://t.co/1MrUw2gVVw@hkumed #HKUMed #WomensHealth pic.twitter.com/8UYhQ3163i

— CMAJ (@CMAJ) July 8, 2019