Comparative efficacy and tolerability of 32 oral antipsychotics for the acute treatment of adults with multi-episode schizophrenia: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentaries: Study Distinguishes Schizophrenia Drug Effects Among Patients – MD Magazine (free) AND New Guidance on Antipsychotic Choice – Medscape (free registration required)

“These findings will aid clinicians in balancing risks versus benefits of those drugs available in their countries. They should consider the importance of each outcome, the patients’ medical problems, and preferences.”


The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness – The Lancet Psychiatry (free registration required)

Executive Summary and Podcast: A blueprint for protecting physical health in people with mental illness (free summary, audio and other resources)

Commentaries: Global commission into health inequities of mental illness gives blueprint for change – NICM Health Research Institute at Western Sydney University (free) AND People with mental illness experience poorer physical health, and the gap may be getting worse, experts say – ABC News (free) AND Why people with mental illness may face poorer physical health and early death – CNN (free)

Related WHO Guideline: Management of Physical Health Conditions in Adults with Severe Mental Disorders (free)


Related Commentary on Twitter (Thread – Click for More)


Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing – Korean Journal of Family Medicine (free PDF)

“individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.”


Physician Burnout: A Global Crisis

12 Jul, 2019 | 07:57h | UTC

Survey: Suicide Amongst Anesthetists

4 Jul, 2019 | 10:47h | UTC

Suicide amongst anaesthetists – an Association of Anaesthetists survey – Anaesthesia (free)

News Release: Survey highlights need for improved mental health guidance & support for anaesthetists – Association of Anaesthetists (free)


Related Commentary on Twitter


WHO Redefines Burnout As A ‘Syndrome’ Linked To Chronic Stress At Work – NPR (free)

See also: Burn-out an “occupational phenomenon”: International Classification of Diseases – World Health Organization (free)


Related Commentary on Twitter


Study: Alcohol-related Harm to Others

13 May, 2019 | 01:08h | UTC

BMJ Review: Depression in Primary Care

9 Apr, 2019 | 02:11h | UTC

State of the Art Review: Depression in primary care: part 1—screening and diagnosis – The BMJ (free for a limited period)

Depression in primary care: part 2—management


Related Commentary on Twitter


Brazilian guidelines for the management of psychomotor agitation – Brazilian Journal of Psychiatry (free articles)

Part 1. Non-pharmacological approach

Part 2. Pharmacological approach


FDA approves new nasal spray medication for treatment-resistant depression; available only at a certified doctor’s office or clinic – U.S. Food & Drug Administration (free)

Commentaries: A ketamine-like drug is the first new antidepressant to get FDA approval in years: But it’s also controversial. – Vox (free) AND FDA Approves Intranasal Esketamine as Adjunctive Treatment for Depression – NEJM Journal Watch (free)

“But while some patient and doctor groups are hailing the approval, others aren’t so sure there’s enough evidence to justify it. That’s because the benefits of ketamine and esketamine aren’t yet well-understood. According to the FDA, the drug has only been studied in four clinical trials, three of them lasting just four weeks. And the results were pretty mixed.” (from Vox)


Related Commentary on Twitter


Deprescribing benzodiazepine receptor agonists taken for insomnia: a review and key messages from practice guidelines – Polish Archives of Internal Medicine (free PDF)

Related: Guideline: Deprescribing Benzodiazepines (free guideline and resources) AND Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)



This Is Your Brain Off Facebook – The New York Times (10 articles per month are free)

Original randomized trial, involving nearly 3000 individuals: The Welfare Effects of Social Media (free PDF)

“Expect the consequences to be fairly immediate: More in-person time with friends and family. Less political knowledge, but also less partisan fever. A small bump in one’s daily moods and life satisfaction. And, for the average Facebook user, an extra hour a day of downtime.”


Prevalence of Cannabis Use Among Medical Students: A Systematic Review and Meta-analysis – Substance Abuse: Research and Treatment (free)

“1 in 3 medical students has used cannabis, whereas 8.8% were current users”


Study: Suicide Among Cancer Patients

15 Jan, 2019 | 00:13h | UTC

Study: Trazodone Associated Risks

30 Nov, 2018 | 02:40h | UTC

Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review – JNCI: Journal of the National Cancer Institute (free)

Commentary: Adverse Mental Health Outcomes in Breast Cancer Survivors – The ASCO Post (free)

“There is compelling evidence of an increased risk of anxiety, depression and suicide, and neurocognitive and sexual dysfunctions in breast cancer survivors compared with women with no prior cancer.”


Review: Lithium and Nephrotoxicity

20 Nov, 2018 | 14:52h | UTC

Antipsychotic drug use and pneumonia: Systematic review and meta-analysis – Journal of Psychopharmacology (link to abstract – $ for full-text)

Commentary: Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests – Psychiatric News Alert (free)

“Although antipsychotic use was associated with a higher risk of pneumonia, the researchers stopped short of claiming causality, citing a lack of data from randomized, controlled trials and a failure of observational studies to control for relevant confounders like tobacco use and weight.” (from Psychiatric News Alert)


Perioperative alcohol cessation intervention for postoperative complications – Cochrane Library (free)

Summary: Effects of perioperative alcohol cessation interventions on postoperative complications following surgery – Cochrane Library (free)

“Intensive alcohol cessation interventions offered for four to eight weeks to participants undergoing all types of surgical procedures to achieve complete alcohol cessation before surgery probably reduced the number of postoperative complications.”


Antidepressant withdrawal: reviewing the paper behind the headlines – The Mental Elf (free) (via @AllenFrancesMD)

Original Systematic Review: Antidepressant Withdrawal Effects (free article and commentaries)

“Last week a new review said: – Over half of people taking antidepressants experience withdrawal symptoms – These symptoms are severe in over half of cases. The press had a field day! Our blog today by @J_F_Hayes and @sameerjauhar offers a different view” (via @Mental_Elf see Tweet)


Review: Demystifying Serotonin Syndrome

16 Oct, 2018 | 23:23h | UTC

800,000 people kill themselves every year. What can we do? – The Guardian (free) (via @onisillos)

Related Guidelines: Preventing suicide: A community engagement toolkit – World Health Organization (free PDF) AND Preventing suicide in community and custodial settings – National Institute for Health and Care Excellence (free)

“In too many places mental health support services are non-existent and those with treatable conditions are criminalized. Bold action is long overdue”


Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentaries: Limiting children’s recreational screen time to less than 2 hours a day linked to better cognition – The Lancet (free) AND Limiting children’s screen time linked to better cognition, study says – CNN (free) AND Limiting children’s screen time linked to better cognition – BBC (free)

“Researchers said more work was now needed to better understand the effects of different types of screen use. However, they acknowledge that their observational study shows only an association between screen time and cognition and cannot prove a causal link.” (from BBC)


Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies – Molecular Psychiatry (link to abstract – $ for full-text)

Commentaries: Plant-rich diets may help prevent depression – new evidence – The Conversation (free) AND Eating a Mediterranean diet ‘may lower your risk of depression’ – NHS Choices (free) AND Expert reaction to observational studies on diet and depression – Science Media Centre (free) AND Mediterranean diet could prevent depression, new study finds – CNN (free)

“The current evidence is not sufficient to prove plant-rich diets can prevent depression as most of the evidence so far simply shows that those with poorer mental health eat worse, so it may be that those more prone to depression also choose less health” (from CNN)


Podcast: Geriatric Depression

27 Sep, 2018 | 22:45h | UTC