Open access

NEWS - Psychiatry

Do Antidepressants Work? – The New York Times (10 articles per month are free)

“The most comprehensive study on them has recently been published, showing mostly modest effects”.

See related meta-analysis and commentaries in our February 23rd issue (see #3)


Effectiveness of brief alcohol interventions in primary care populations – Cochrane Library (free)

In general practice or emergency care settings, brief alcohol interventions can reduce alcohol consumption and related harm.


Guidelines for Adolescent Depression in Primary Care – American Academy of Pediatrics

Part I. Practice Preparation, Identification, Assessment, and Initial Management (free)

Part II. Treatment and Ongoing Management (free)

Commentary: Pediatricians Call For Universal Depression Screening For Teens – NPR (free)


Comparative Effectiveness and Safety of Cognitive Enhancers for Treating Alzheimer’s Disease: Systematic Review and Network Meta-analysis – Journal of the American Geriatrics Society (free)

Source: Medscape (free registration required)

“Cognitive enhancers in general have minimal effects on cognition according to minimal clinically important difference and global ratings. The drugs appear safe, but this must be interpreted cautiously because trial participants may have less comorbidity and fewer adverse effects than those treated with these drugs in clinical practice”.


Electroconvulsive therapy and age: Age-related clinical features and effectiveness in treatment resistant major depressive episode – Journal of Affective Disorders (link to abstract – $ for full-text)

“Short-term ECT outcome in the treatment of depression in elderly is equivalent to that of young patients in efficacy and tolerability. Old patients reported faster ECT response than younger ones and required less sessions to achieve response and remission” (via @psychopharmacol see Tweet)


Atypical antipsychotics, insulin resistance and weight; a meta-analysis of healthy volunteer studies – Progress in Neuro-Psychopharmacology and Biological Psychiatry (link to abstract – $ for full-text) (via @psychopharmacol see Tweet)

“These findings provide preliminary evidence that atypical antipsychotics cause insulin resistance and weight gain directly, independent of psychiatric disease and may be associated with length of treatment”.


Postsurgical prescriptions for opioid naive patients and association with overdose and misuse: retrospective cohort study – The BMJ (free)

“The duration of treatment rather than dose is more strongly associated with opioid misuse after surgery, concludes this study” (via @bmj_latest see Tweet)


Editorial: Children and social media – The Lancet (free)

Original report: Life in ‘likes’ – Children’s Commissioner (free)

See also a recent Pediatrics supplement: Children, Adolescents and Screens: What We Know and What We Need To Learn (series of free articles) and related articles on Social Media and Mental Health


The role of selective serotonin reuptake inhibitors in preventing relapse of major depressive disorder – Therapeutic Advances in Psychotherapy (free PDF)

“Review: The relapse risk during 1 year in adults with MDD was lower when SSRIs were combined with psychotherapy. Results comparing SSRIs and SNRIs were inconclusive. TCAs may be equally as effective as SSRIs” (via @psychopharmacol see Tweet)


Practice guideline update summary: Mild cognitive impairment – American Academy of Neurology (free PDF)

Commentary: Mild cognitive impairment: a practice guideline update – Clinical Advisor (free)

“For patients diagnosed with MCI, clinicians may choose NOT to offer cholinesterase inhibitors”.

“If clinicians choose to offer cholinesterase inhibitors, they must first discuss with patients the fact that this is an off-label prescription not currently backed by empirical evidence”.


Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentary: Electrical Stimulation Works as Add-On in Bipolar Depression – MedPage Today (free registration required)

“Small RCT in BD I and II (n=59): active tDCS showed superior improvement versus sham in change in HDRS-17 scores at week 6 (βint = −1.68; NNT = 5.8; 3.3-25.8) and response rates (67.6% vs 30.4%; NNT = 2.69; 1.84-4.99)” (RT @psychopharmacol see Tweet)


Treating Anxiety in Children – The New York Times (10 articles per month are free)


Aerobic exercise moderately reduces depressive symptoms in new mothers – NIHR Signal (free)

Original article: Does aerobic exercise reduce postpartum depressive symptoms? a systematic review and meta-analysis – British Journal of General Practice (free)

“Involving new mothers in group exercise programmes, or advising them on an exercise of their choice, reduced depressive symptoms compared with usual care” (RT @NIHR_DC see Tweet)


Children, Adolescents and Screens: What We Know and What We Need To Learn – Pediatrics Supplement (free articles)

Table of contents

– Introduction

– Digital Screen Media and Cognitive Development

– Media Multitasking and Cognitive, Psychological, Neural, and Learning Differences

– Benefits and Costs of Social Media in Adolescence

– Digital Life and Youth Well-being, Social Connectedness, Empathy, and Narcissism

– Digital Media, Anxiety, and Depression in Children

– Internet Gaming Disorder in Children and Adolescents

– Virtual Reality in Pediatric Psychology

– Digital Media and Sleep in Childhood and Adolescence

– Screen Media Exposure and Obesity in Children and Adolescents

– Digital Media and Risks for Adolescent Substance Abuse and Problematic Gambling

– Small Screen Use and Driving Safety

– Parenting and Digital Media

– Children’s Privacy in the Big Data Era: Research Opportunities

– Developing Digital and Media Literacies in Children and Adolescents

– Digital Media, Participatory Politics, and Positive Youth Development

– Digital Inequality and Developmental Trajectories of Low-income, Immigrant, and Minority Children

– Global Perspectives on Children’s Digital Opportunities: An Emerging Research and Policy Agenda

– Screen Violence and Youth Behavior

– Defining Cyberbullying

– The Effect of Advertising on Children and Adolescents

– Social Group Stories in the Media and Child Development

– Sexual Media and Childhood Well-being and Health


Taking Care of the Physician – The New York Times (10 articles per month are free)


Clinical Management of Insomnia Disorder – JAMA (free)

“Cognitive Behavior Therapy for insomnia is recommended as 1st-line Tx; pharmacotherapy, if used, should be on a short-term basis” (RT @JAMAInternalMed see Tweet)


We Need to Talk About Kids and Smartphones – TIME (free)

Related: Have Smartphones Destroyed a Generation? – The Atlantic (free)

“Just how dangerous are smartphones for kids? Here’s why health experts are worried”


How Smartphones Hijack Our Minds – The Wall Street Journal (free) (RT @EricTopol see Tweet)

“Research suggests that as the brain grows dependent on phone technology, the intellect weakens”


Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies – Journal of The American Heart Association (free)

“Our findings indicate that both short and long sleep duration is associated with an increased risk of all‐cause mortality and cardiovascular events”.


Antipsychotic Use With and Without Comorbid Psychiatric Diagnosis Among Adults with Intellectual and Developmental Disabilities – The Canadian Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Antipsychotics common for adults with intellectual and developmental disabilities – Centre for Addiction and Mental Health (free) AND Antipsychotics Overused in Intellectually Disabled Adults – Medscape (free registration required)

“Antipsychotics are used inappropriately particularly in vulnerable groups: Poor children; Intellectually challenged; Autistic; Nursing homes. (RT @AllenFrancesMD see Tweet)


Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Breathing Disorders During Sleep Tied to Cognitive Issues – MedPage Today (free registration required) AND Sleep-Disordered Breathing Raises Risk for Cognitive Decline – Medscape (free registration required)

This meta-analysis of observational studies suggests a possible association. Further studies are needed to examine whether the treatment of this condition can help in the prevention of dementia and in improvement of cognition.


Online parental training may help to improve behaviour in children – NIHR Signal (free)

Original article: Technology-Assisted Parent Training Programs for Children and Adolescents With Disruptive Behaviors: A Systematic Review – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)


Lithium Use, but Not Valproate Use, Is Associated With a Higher Risk of Chronic Kidney Disease in Older Adults With Mental Illness – The Journal of Clinical Psychiatry (link to abstract -$ for full-text)

Case-control study suggests Lithium is associated with increased risk of chronic kidney disease.


Suicide Prevention in an Emergency Department Population: The ED-SAFE Study – JAMA Psychiatry (link to abstract – Free Full Text PDF via @unpaywall)

Commentaries: Intervention Phone Calls May Save The Lives Of Suicidal Patients, Reduce New Attempts, Trial Finds – Medical Daily (free) AND National study shows interventions like telephone calls can reduce suicides – EurekAlert (free) AND Intervention Curbs New Suicide Attempts in At-Risk ED Patients – Medscape (free registration required)

Source: Psychiatry Research Review

“Patients who received a multifaceted intervention that included follow-up telephone calls resulted in a 30 percent reduction in future suicide attempts” (from Medical Daily)


What do hypnotics cost hospitals and healthcare? – F1000 Research (free)

Source: Hospital Medicine Virtual Journal Club

“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.


Have Smartphones Destroyed a Generation? – The Atlantic (free)

Long read… very interesting.


Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Antipsychotic Response Rates Through the Prism of 60 Years – Psychiatric Times (free)

Source: EvidenceAlerts (free resource to find articles of interest)

Twice as many patients improved with antipsychotics as with placebo, confirming the benefits of antipsychotic drugs for the treatment of schizophrenia.



Simultaneous Antidepressant and Benzodiazepine New Use and Subsequent Long-term Benzodiazepine Use in Adults With Depression, United States, 2001-2014 – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Benzodiazepines With Antidepressants May Spark Long-term Use – Medscape (free registration required) AND Antidepressants plus benzos: Is it worth the risk? – Pharmacy News (free)

In this large cohort, patients who were treated with benzodiazepine associated with antidepressants in the beginning of the treatment for depression didn’t seem to have a clinical benefit, and 12.3% of patients who began treatment with both agents had long-term (6-month) benzodiazepine use. Due to the observational nature of this study, it may be that these patients had more severe depression, but caution is advised nonetheless.


Risk of Irritability With Psychostimulant Treatment in Children With ADHD: A Meta-Analysis – Journal of Clinical Psychiatry (link to abstract – $ for full-text)

“MPH decreased risk of irritability vs PLA (RR=0.89), whereas amphetamines increased the risk (RR=2.90)” (RT @psychopharmacol see Tweet)


Helping Those Who Hoard – The New York Times (10 articles per month are free)


Page 1 of 212

Stay updated in your specialty!

No spam, just news
Unsubscribe with one click