Psychiatry
Cohort Study: Metabolic biomarkers and long-term risk of psychiatric disorders in over 200,000 individuals
27 Apr, 2024 | 18:29h | UTCStudy Design and Population:
This population-based cohort study assessed 211,200 participants from the Apolipoprotein-Related Mortality Risk (AMORIS) cohort, who underwent occupational health screening primarily in the Stockholm region of Sweden from 1985 to 1996. Participants were followed longitudinally, with statistical analysis performed between 2022 and 2023. The study included extensive biomarker measurements such as glucose, triglycerides, and high-density lipoprotein.
Main Findings:
The study found significant associations between certain metabolic biomarkers and the risk of developing psychiatric disorders such as depression, anxiety, and stress-related disorders. Specifically, high levels of glucose (HR, 1.30) and triglycerides (HR, 1.15) were linked to an increased risk of these disorders, while high levels of high-density lipoprotein (HR, 0.88) were associated with a reduced risk. These findings held true across both genders and all disorders tested, with nested case-control analyses confirming these trends.
Implications for Practice:
The study suggests that metabolic dysregulation, as indicated by specific biomarkers, may either increase the risk or be a marker of increased risk for the development of common psychiatric disorders. These findings support the potential for closer monitoring and follow-up of individuals with abnormal metabolic profiles to aid in the prevention and early diagnosis of psychiatric conditions.
Reference (free full-text):
RCT | Field sobriety tests display insufficient accuracy for detecting THC-specific driving impairment
11 Aug, 2023 | 15:14h | UTCSee also: Visual Abstract
News Release: Can field sobriety tests identify drivers under the influence of cannabis? – University of California – San Diego
Commentary on Twitter
This randomized clinical trial investigates the accuracy of field sobriety tests administered by law enforcement officers to assess functional impairment and driving performance among individuals who have smoked cannabis. https://t.co/pThOOdZGUh
— JAMA Psychiatry (@JAMAPsych) August 2, 2023
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9 Aug, 2023 | 15:25h | UTC
M-A | Absence of evidence for antipsychotics in youth unipolar depression; limited evidence in bipolar depression
9 Aug, 2023 | 15:23h | UTC
Cohort Study | Clozapine, but not olanzapine or quetiapine, linked with higher perimyocarditis and heart failure risk
8 Aug, 2023 | 13:14h | UTC
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4 Aug, 2023 | 12:11h | UTCDuration of Adjunctive Antidepressant Maintenance in Bipolar I Depression – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Modern antidepressants may reduce risk of relapse for patients with bipolar depression – University of British Columbia
Commentary on Twitter
Among patients with bipolar I disorder who had remission of depression, there was no significant difference in the incidence of relapse of any mood episode between 8 weeks and 52 weeks of antidepressant treatment. Full results of the BEAM-BD trial: https://t.co/rCkCqIfMb6
— NEJM (@NEJM) August 2, 2023
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3 Aug, 2023 | 13:35h | UTC
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3 Aug, 2023 | 13:20h | UTCTrends in Alcohol-Related Deaths by Sex in the US, 1999-2020 – JAMA Network Open
Commentary: As alcohol-related deaths rise in the US, women are increasingly at risk, study shows – CNN
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2 Aug, 2023 | 14:05h | UTCAlcohol dependence: evidence and experience on 12 steps to recovery – Evidently Cochrane
Original study: Alcoholics Anonymous and other 12‐step programs for alcohol use disorder – Cochrane Library
Cohort Study | Depression at any life stage linked to increased dementia incidence
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Commentary: Depression Over Adulthood May Increase Risk of Dementia – Psychiatric News Alert
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31 Jul, 2023 | 13:53h | UTC
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Commentary on Twitter
In a randomized trial involving patients with narcolepsy, an oral orexin receptor 2 agonist reduced sleepiness and cataplexy but had liver toxic effects. Read the full trial results: https://t.co/Go7lmQTu62
— NEJM (@NEJM) July 26, 2023
RCT | Zuranolone, a potential rapid-acting oral treatment for severe postpartum depression
27 Jul, 2023 | 13:00h | UTCZuranolone for the Treatment of Postpartum Depression – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentary: Postpartum Depression Pill Zuralonone Shows Promise in Women With Severe Symptoms – Psychiatric News Alert
Related: RCT | Zuranolone outperforms placebo in major depressive disorder treatment
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26 Jul, 2023 | 13:28h | UTC
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25 Jul, 2023 | 13:37h | UTC
Cohort Study | Increased risk of depression and suicide among people with HIV, especially in the first two years post-diagnosis
24 Jul, 2023 | 13:01h | UTC
Commentary on Twitter
Risk of Depression in People With HIV: A nationwide population-based matched cohort study
✅ Just Accepted
? Freely Availablehttps://t.co/nyrzPqRRqw— Clinical Infectious Diseases (@CIDJournal) July 22, 2023
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24 Jul, 2023 | 12:39h | UTCSee also: Visual Abstract
News Release: Internet-based therapy effective against self-harm in adolescents – Karolinska Institutes
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M-A | Adverse effects of antipsychotics on sleep in patients with schizophrenia
18 Jul, 2023 | 13:45h | UTC
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Meta-Analysis | Nearly 6% of first-episode psychosis patients exhibit clinically relevant MRI abnormalities
17 Jul, 2023 | 13:32h | UTCNews Release: Routine brain scanning may improve clinical care for people with psychosis – University of Oxford
Cohort Study | Mental disorders linked to increased cardiovascular events in young patients
17 Jul, 2023 | 13:20h | UTCIncreased cardiovascular events in young patients with mental disorders: a nationwide cohort study – European Journal of Preventive Cardiology (free for a limited period)
News Release: Under 40s with mental health problems have elevated risks of heart attack and stroke – European Society of Cardiology
RCT | 4-week course of subcutaneous ketamine shows efficacy in treatment-resistant depression
17 Jul, 2023 | 13:17h | UTCNews Release: Ketamine effective for treatment-resistant depression: Clinical trial – University of New South Wales
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RCT | Ketamine non-Inferiority to ECT for nonpsychotic resistant depression
Clinical practice guideline for deprescribing opioid analgesics
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RCT | Opioids not more effective than placebo for acute low back and neck pain
RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care
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Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
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Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety