Open access


Aerobic exercise moderately reduces depressive symptoms in new mothers – NIHR Signal (free)

Original article: Does aerobic exercise reduce postpartum depressive symptoms? a systematic review and meta-analysis – British Journal of General Practice (free)

“Involving new mothers in group exercise programmes, or advising them on an exercise of their choice, reduced depressive symptoms compared with usual care” (RT @NIHR_DC see Tweet)


Children, Adolescents and Screens: What We Know and What We Need To Learn – Pediatrics Supplement (free articles)

Table of contents

– Introduction

– Digital Screen Media and Cognitive Development

– Media Multitasking and Cognitive, Psychological, Neural, and Learning Differences

– Benefits and Costs of Social Media in Adolescence

– Digital Life and Youth Well-being, Social Connectedness, Empathy, and Narcissism

– Digital Media, Anxiety, and Depression in Children

– Internet Gaming Disorder in Children and Adolescents

– Virtual Reality in Pediatric Psychology

– Digital Media and Sleep in Childhood and Adolescence

– Screen Media Exposure and Obesity in Children and Adolescents

– Digital Media and Risks for Adolescent Substance Abuse and Problematic Gambling

– Small Screen Use and Driving Safety

– Parenting and Digital Media

– Children’s Privacy in the Big Data Era: Research Opportunities

– Developing Digital and Media Literacies in Children and Adolescents

– Digital Media, Participatory Politics, and Positive Youth Development

– Digital Inequality and Developmental Trajectories of Low-income, Immigrant, and Minority Children

– Global Perspectives on Children’s Digital Opportunities: An Emerging Research and Policy Agenda

– Screen Violence and Youth Behavior

– Defining Cyberbullying

– The Effect of Advertising on Children and Adolescents

– Social Group Stories in the Media and Child Development

– Sexual Media and Childhood Well-being and Health


Taking Care of the Physician – The New York Times (10 articles per month are free)


Clinical Management of Insomnia Disorder – JAMA (free)

“Cognitive Behavior Therapy for insomnia is recommended as 1st-line Tx; pharmacotherapy, if used, should be on a short-term basis” (RT @JAMAInternalMed see Tweet)


We Need to Talk About Kids and Smartphones – TIME (free)

Related: Have Smartphones Destroyed a Generation? – The Atlantic (free)

“Just how dangerous are smartphones for kids? Here’s why health experts are worried”


How Smartphones Hijack Our Minds – The Wall Street Journal (free) (RT @EricTopol see Tweet)

“Research suggests that as the brain grows dependent on phone technology, the intellect weakens”


Relationship of Sleep Duration With All‐Cause Mortality and Cardiovascular Events: A Systematic Review and Dose‐Response Meta‐Analysis of Prospective Cohort Studies – Journal of The American Heart Association (free)

“Our findings indicate that both short and long sleep duration is associated with an increased risk of all‐cause mortality and cardiovascular events”.


Antipsychotic Use With and Without Comorbid Psychiatric Diagnosis Among Adults with Intellectual and Developmental Disabilities – The Canadian Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Antipsychotics common for adults with intellectual and developmental disabilities – Centre for Addiction and Mental Health (free) AND Antipsychotics Overused in Intellectually Disabled Adults – Medscape (free registration required)

“Antipsychotics are used inappropriately particularly in vulnerable groups: Poor children; Intellectually challenged; Autistic; Nursing homes. (RT @AllenFrancesMD see Tweet)


Association of Sleep-Disordered Breathing With Cognitive Function and Risk of Cognitive Impairment: A Systematic Review Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Breathing Disorders During Sleep Tied to Cognitive Issues – MedPage Today (free registration required) AND Sleep-Disordered Breathing Raises Risk for Cognitive Decline – Medscape (free registration required)

This meta-analysis of observational studies suggests a possible association. Further studies are needed to examine whether the treatment of this condition can help in the prevention of dementia and in improvement of cognition.


Online parental training may help to improve behaviour in children – NIHR Signal (free)

Original article: Technology-Assisted Parent Training Programs for Children and Adolescents With Disruptive Behaviors: A Systematic Review – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)


Lithium Use, but Not Valproate Use, Is Associated With a Higher Risk of Chronic Kidney Disease in Older Adults With Mental Illness – The Journal of Clinical Psychiatry (link to abstract -$ for full-text)

Case-control study suggests Lithium is associated with increased risk of chronic kidney disease.


Suicide Prevention in an Emergency Department Population: The ED-SAFE Study – JAMA Psychiatry (link to abstract – Free Full Text PDF via @unpaywall)

Commentaries: Intervention Phone Calls May Save The Lives Of Suicidal Patients, Reduce New Attempts, Trial Finds – Medical Daily (free) AND National study shows interventions like telephone calls can reduce suicides – EurekAlert (free) AND Intervention Curbs New Suicide Attempts in At-Risk ED Patients – Medscape (free registration required)

Source: Psychiatry Research Review

“Patients who received a multifaceted intervention that included follow-up telephone calls resulted in a 30 percent reduction in future suicide attempts” (from Medical Daily)


What do hypnotics cost hospitals and healthcare? – F1000 Research (free)

Source: Hospital Medicine Virtual Journal Club

“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.


Have Smartphones Destroyed a Generation? – The Atlantic (free)

Long read… very interesting.


Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Antipsychotic Response Rates Through the Prism of 60 Years – Psychiatric Times (free)

Source: EvidenceAlerts (free resource to find articles of interest)

Twice as many patients improved with antipsychotics as with placebo, confirming the benefits of antipsychotic drugs for the treatment of schizophrenia.



Simultaneous Antidepressant and Benzodiazepine New Use and Subsequent Long-term Benzodiazepine Use in Adults With Depression, United States, 2001-2014 – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Benzodiazepines With Antidepressants May Spark Long-term Use – Medscape (free registration required) AND Antidepressants plus benzos: Is it worth the risk? – Pharmacy News (free)

In this large cohort, patients who were treated with benzodiazepine associated with antidepressants in the beginning of the treatment for depression didn’t seem to have a clinical benefit, and 12.3% of patients who began treatment with both agents had long-term (6-month) benzodiazepine use. Due to the observational nature of this study, it may be that these patients had more severe depression, but caution is advised nonetheless.


Risk of Irritability With Psychostimulant Treatment in Children With ADHD: A Meta-Analysis – Journal of Clinical Psychiatry (link to abstract – $ for full-text)

“MPH decreased risk of irritability vs PLA (RR=0.89), whereas amphetamines increased the risk (RR=2.90)” (RT @psychopharmacol see Tweet)


Helping Those Who Hoard – The New York Times (10 articles per month are free)


Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Study Compares Switching Meds vs an Additional Med for Patients Unresponsive to an Antidepressant – The Jama Network (free) AND For Treatment-Resistant Depression, Add an Antipsychotic or Switch Antidepressants? – Physician’s First Watch (free)

Augmentation with aripiprazole led to a modestly increased likelihood of remission, but with more adverse effects. “Given the small effect size and adverse effects associated with aripiprazole, further analysis including cost-effectiveness is needed to understand the net utility of this approach”.


Treating Anxiety in 2017: Optimizing Care to Improve Outcomes – JAMA (free)

“Exercise, mindfulness-based stress reduction = 1st-line treatments for anxiety; move on to SSRIs and CBT as needed” (RT @JAMA_current see Tweet)


Association of Electroconvulsive Therapy With Psychiatric Readmissions in US Hospitals – JAMA Psychiatry (free)

Editorial: Modern Electroconvulsive Therapy: Vastly Improved Yet Greatly Underused – JAMA Psychiatry (free) (RT @JAMA_current see Tweet)

In this observational study, electroconvulsive therapy was associated with reduced 30-day readmission risk among psychiatric inpatients with severe affective disorders (RR=0.54;0.28-0.81).


Practice: I am your trans patient – The BMJ (free)

Related infographic: Managing disclosure of gender dysphoria – The BMJ (free PDF)

“Five transgender authors share their experiences of healthcare & the important messages they’d like doctors to know” (RT @bmj_latest see Tweet)


When Anxiety or Depression Masks a Medical Problem – New York Times (10 articles month are free)

Related: Managing Anxiety in the Medically Ill – Psychiatric Times (free)

“Very 1st differential before making a psych diagnosis should be – is this due to medical problem? 2nd question – medication/substance/alcohol? (RT @AllenFrancesMD see Tweet)


Trial of Electrical Direct-Current Therapy versus Escitalopram for Depression – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: A New Brain-Stimulation Treatment Disappoints – Physician’s First Watch (free)

“For depression, new transcranial direct current stimulation treatment is not as effective as escitalopram” (RT @JWatch see Tweet)


Spasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers – Medscape (free registration required)

Unpublished results, presented at the 13th World Congress of Biological Psychiatry, suggesting baclofen is an effective alternative for high-risk alcohol consumption.


Real-World Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of 29 823 Patients With Schizophrenia – JAMA Internal Medicine(link to abstract – $ for full-text)

Commentaries: Oral clozapine, long-acting injectables tied to lower relapse risk in schizophrenia – Clinical Psychiatry News (free registration required) AND Long-Acting Antipsychotics Tied to Superior Outcomes – Medscape (free registration required)

“The risk of rehospitalization is about 20% to 30% lower during long-acting injectable treatments compared with equivalent oral formulations”


Medical News & Perspectives: More Treatments on Deck for Alcohol Use Disorder – JAMA (free)


Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free)

“Students used to take drugs to get high. Now they take them to get higher grades” (RT @ConversationUK see Tweet)


Survey and commentaries: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free)

Increased in clerical burden seems to be one of the leading causes, heavily influenced by expanded and more comprehensive use of electronic health records. More on the burden of administrative tasks in healthcare in our April 21 issue, see #5.


Press release: “Depression: let’s talk” says WHO, as depression tops list of causes of ill health – World Health Organization (free)

See also: Depression: let’s talk – WHO campaign (free) AND Depression updated factsheet (free) AND Depression and Other Common Mental Disorders: Global Health Estimates (free)

Depression is now the leading cause of ill health and disability worldwide, according to The World Health Organization.


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