Higher doses of antidepressants “not optimal”, according to new review – The Mental Elf (free)

Original Article: Meta-analysis: Optimal Dose of Antidepressants in Major Depression (free study and commentaries)

Associations between gabapentinoids and suicidal behaviour, unintentional overdoses, injuries, road traffic incidents, and violent crime: population based cohort study in Sweden – The BMJ (free)

Editorial: Gabapentinoids linked to new risks, including suicidal behavior (free)

Commentaries: Epilepsy drugs linked to increased risk of suicidal behavior, particularly in young people – The BMJ (free) AND Expert reaction to study on gabapentinoids and risk of suicidal behavior – Science Media Centre (free)

Optimal dose of selective serotonin reuptake inhibitors, venlafaxine, and mirtazapine in major depression: a systematic review and dose-response meta-analysis – The Lancet Psychiatry (free)

Commentaries: Which antidepressant doses are optimal? – The Lancet Psychiatry (free) AND Expert reaction to systematic review and dose-response meta-analysis of antidepressants – Science Media Centre (free)

Managing opioid use disorder in primary care: PEER simplified guideline – Canadian Family Physician (free)

Related: Opioid use disorder in primary care: PEER umbrella systematic review of systematic reviews – Canadian Family Physician (free)

Lithium for acute mania – Cochrane Library (free)

Summary: Lithium for the treatment of acute mania – Cochrane Library (free)

Effect of Exposure to Gun Violence in Video Games on Children’s Dangerous Behavior With Real Guns: A Randomized Clinical Trial – JAMA Network Open (free)

Commentaries: Gun Violence in Video Games and Subsequent Firearm Play: An Argument for the Safe Storage of Firearms – JAMA Network Open (free) AND Kids who play violent videogames may be more likely to pick up a gun and pull the trigger – Reuters (free) AND Expert reaction to study on violent video games and behaviour with real guns – Science Media Centre (free)

Antidepressants and weight gain: long-term population impact #SUSANAsurvey – The Mental Elf (free)

Original Study: Cohort Study: Weight Gain with Antidepressant Utilization (free study and commentaries)

The Serotonin Syndrome: From Molecular Mechanisms to Clinical Practice – International Journal of Molecular Sciences (free)

WHO Redefines Burnout As A ‘Syndrome’ Linked To Chronic Stress At Work – NPR (free)

See also: Burn-out an “occupational phenomenon”: International Classification of Diseases – World Health Organization (free)

Related Commentary on Twitter

#Burnout is included in the 11th Revision of the International Classification of Diseases (#ICD11) as an occupational phenomenon.
It is NOT classified as a medical condition https://t.co/t9pjcv3ctX pic.twitter.com/FF6Zzfwoj7

— World Health Organization (WHO) (@WHO) May 28, 2019

Estimating the Attributable Cost of Physician Burnout in the United States – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Physician burnout costs the US health care system approximately $4.6 billion a year – American College of Physicians (free) AND Doctors are burning out twice as fast as other workers. The problem’s costing the US $4.6 billion each year. – Business Insider (free) AND Physician Burnout Costs the U.S. Billions of Dollars Each Year – TIME (free)

Related: Physician Burnout Costs up to $17B a Year, Task Force Says (articles and commentaries on the subject)

Related Commentary on Twitter

The economics of doctor burnout: ~$5B/year, and that isn't even factoring in the cost of the doubling of medical errors https://t.co/fqn0LenWzl @AnnalsofIM pic.twitter.com/ZLNOhvYB1h

— Eric Topol (@EricTopol) May 27, 2019

Evolving Issues in the Treatment of Depression – JAMA (free for a limited period)

Author Interview: New Approaches to Management of Depression (free audio)

European guidelines for personality disorders: past, present and future – Borderline Personality Disorder and Emotion Dysregulation (free)

Antidepressant withdrawal: slower and lower tapering of SSRIs – The Mental Elf (free)

Related: Antidepressant Withdrawal Syndrome – Therapeutics Initiative (free) AND Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)

Trends in Suicide Among Youth Aged 10 to 19 Years in the United States, 1975 to 2016 – JAMA Network Open (free)

Commentaries: Increasing Suicide Rates in Early Adolescent Girls in the United States and the Equalization of Sex Disparity in Suicide: The Need to Investigate the Role of Social Media – JAMA Network Open (free) AND Suicide Rate For Girls Has Been Rising Faster Than For Boys, Study Finds – NPR (free) AND Suicide rates in girls are rising, study finds, especially in those age 10 to 14 – CNN (free)

A Review of Novel Antidepressants: A Guide for Clinicians – Cureus (free)

Mental health in elite athletes: International Olympic Committee consensus statement (2019) – British Journal of Sports Medicine (free)

How Much Alcohol Can You Drink Safely? – The New York Times Magazine (10 articles per month are free)

Related Articles: Alcohol Use and Burden for 195 Countries and Territories (free) AND Meta-analysis: Risk Thresholds for Alcohol Consumption (free )

Alcohol-related harm to others in England: a cross-sectional analysis of national survey data – BMJ Open (free)

Commentaries: One in five people in England harmed by others’ drinking over past year – Blog BMJ Open (free) AND One in five people harmed by other people’s drinking – OnMedica (free) AND One in five harmed by others drinking alcohol over past year, survey finds – The Guardian (free) AND Expert reaction to study quantifying the harm of other people’s drinking – Science Media Centre (free)

Internet-delivered cognitive behaviour therapy for chronic health conditions: a systematic review and meta-analysis – Journal of Behavioral Medicine (free)

Management of perinatal depression with non-drug interventions – The BMJ (free)

International incidence of psychotic disorders, 2002–17: a systematic review and meta-analysis – The Lancet Public Health (free)

Commentary: Towards a public health approach to psychotic disorders – The Lancet Public Health (free)

FDA requires stronger warnings about rare but serious incidents related to certain prescription insomnia medicines – U.S. Food & Drug Administration (Free)

For Consumers: Taking Z-drugs for Insomnia? Know the Risks – U.S. Food & Drug Administration (free)

Commentaries: Drug Agency Calls for Strong Warning Labels on Popular Sleep Aids – The New York Times (10 articles per month are free) AND FDA Requires Stronger Warnings for Common Insomnia Medications – Psychiatric News Alert (free)

Release of “13 Reasons Why” associated with increase in youth suicide rates – NIH News Releases (free)

Original Study: Association Between the Release of Netflix’s 13 Reasons Why and Suicide Rates in the United States: An Interrupted Times Series Analysis – Journal of the American Academy of Child and Adolescent Psychiatry (link to abstract – $ for full-text)

Related Study: Internet Searches for Suicide Following the Release of “13 Reasons Why” (free study and commentaries)

“NIH-supported study highlights the importance of responsible portrayal of suicide by the media.”

Self-management interventions for people with severe mental illness: systematic review and meta-analysis – The British Journal of Psychiatry (free)

The Effects of Dietary Improvement on Symptoms of Depression and Anxiety: A Meta-Analysis of Randomized Controlled Trials – Psychosomatic Medicine (free)

Commentaries: Healthy diet can ease symptoms of depression – University of Manchester (free) AND Many Different Diets Can Improve Mood And Reduce Depression Symptoms, Study Finds – Forbes (free)

Effectiveness and Acceptability of Cognitive Behavior Therapy Delivery Formats in Adults With Depression: A Network Meta-analysis – JAMA Psychiatry (free for a limited period)

Editorial: Can Network Meta-analysis Substitute for Direct Comparisons in Psychotherapy Trials? (free for a limited period)

Commentaries: Certain Variations of CBT Found as Effective as Individual CBT – Psychiatric News Alert (free) AND Group, telephone, guided CBT treatment effective for depression – MedicalXpress (free)

ACMT Position Statement: Addressing Pediatric Cannabis Exposure – Journal of Medical Toxicology (free)

Towards artificial intelligence in mental health by improving schizophrenia prediction with multiple brain parcellation ensemble-learning – NPJ Schizophrenia (free)

Commentary: Improved AI-based tool increases accuracy of schizophrenia diagnosis – University of Alberta (free)

Different doses, durations and modes of delivery of nicotine replacement therapy for smoking cessation – Cochrane Library (free)

Commentaries: Nicotine replacement: when quitting cigarettes, consider using more nicotine, not less – The Conversation (free) AND Nicotine replacement therapy: new evidence on help to quit smoking – Evidently Cochrane (free) AND Nicotine replacement therapy more successful in combination form – Nuffield Department of Primary Care Health Sciences (free)

Related Commentary on Twitter

Featured Cochrane Review: Different doses, durations and modes of delivery of #nicotine replacement therapy for #smoking cessation from @CochraneTAG – Read comments from lead author https://t.co/WBvMA74iaK and the full review https://t.co/QFLx9Wb9Xc pic.twitter.com/tk2J6WRT3Z

— Cochrane (@cochranecollab) April 18, 2019

Accuracy of Patient Health Questionnaire-9 (PHQ-9) for screening to detect major depression: individual participant data meta-analysis – The BMJ (free)

Commentaries: The accuracy of the Patient Health Questionnaire-9 for detecting major depression – The BMJ Opinion (free) AND Screening tools for depression offer value when combined with an informed shared decision process – The BMJ Opinion (free) AND Using the Patient Health Questionnaire-9 to Screen for Major Depression – NEJM Journal Watch (free)

Smoking cessation for people with severe mental illness (SCIMITAR+): a pragmatic randomised controlled trial – The Lancet Psychiatry (free)

Commentaries: Smoking cessation in people with serious mental illness – The Lancet Psychiatry (free) AND New intervention doubles quit rate among smokers with severe mental illness – University of York (free) AND Smoking cessation for people with severe mental illness? “Oh yes they can!” SCIMITAR+ – The Mental Elf (free)

Stress related disorders and risk of cardiovascular disease: population based, sibling controlled cohort study – The BMJ (free)

Editorial: Stress, psychiatric disorders, and cardiovascular disease (free)

Commentaries: Stress-related disorders linked to heightened risk of cardiovascular disease – The BMJ (free) AND Stress from Traumatic Events Linked to Increased Risk of Heart Disease – MedicalResearch.com (free) AND Expert reaction to study looking at stress related disorders and risk of cardiovascular disease – Science Media Centre (free)

Related Commentary on Twitter

Stress related disorders–conditions triggered by a significant life event or trauma–may be linked to a heightened risk of cardiovascular disease (CVD), finds a large Swedish study published in @bmj_latest today https://t.co/01pyFcInu8 Linked editorial: https://t.co/vt7EWu4g9v pic.twitter.com/F9C77VJ9M2

— BMJ (@bmj_company) April 11, 2019

State of the Art Review: Depression in primary care: part 1—screening and diagnosis – The BMJ (free for a limited period)

Depression in primary care: part 2—management

Related Commentary on Twitter

#BMJInfographic Managing depression—this visual summary provides a guide to options for primary care. Click here to see the interactive version: https://t.co/6LpVKsMYxs @will_s_t pic.twitter.com/dZVsiwkNPF

— The BMJ (@bmj_latest) April 8, 2019

Conventional and genetic evidence on alcohol and vascular disease aetiology: a prospective study of 500 000 men and women in China – The Lancet (free)

Commentaries: Unite for a Framework Convention for Alcohol Control – The Lancet (free) AND Even one alcoholic drink a day can raise risk of stroke, study says – CNN (free) AND Expert reaction to research on alcohol intake and stroke – Science Media Centre (free) AND Major study debunks myth that moderate drinking can be healthy – Reuters (free)

Related: Alcohol Use and Burden for 195 Countries and Territories (free study and commentaries) AND WHO Global Status Report on Alcohol and Health 2018 (free study and commentaries)

Comparative efficacy and acceptability of non-surgical brain stimulation for the acute treatment of major depressive episodes in adults: systematic review and network meta-analysis – The BMJ (free)

Commentary: Consider non-surgical brain stimulation for severe depression, say experts – The BMJ (free)

Systematic Review: Adverse Effects of Pharmacological Treatments of Major Depression in Older Adults – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF) AND Evidence Summary (free PDF)

Clinical guideline for the diagnosis and management of work-related mental health conditions in general practice – National Health and Medical Research Council, Australian Government (NHMRC) (free PDF)

See also: Short Form Guideline (free PDF) AND GP Summary (free PDF)

Commentary: Managing work-related mental health conditions in family medicine  – Canadian Medical Association Journal (free for a limited period)

Related Commentary on Twitter

New guidance aims to support family physicians to help patients whose mental illness arises in the workplace: https://t.co/LomlqKC61J#familymedicine #primarycare #mentalhealth pic.twitter.com/sFN6ji2EHg

— CMAJ (@CMAJ) March 26, 2019

Differences in Parent-Toddler Interactions with Electronic Versus Print Books – Pediatrics (link to abstract – $ for full-text)

Commentaries: Does story time with an e-book change how parents and toddlers interact? – University of Michigan (free) AND Print Books Better Than E-Books for Parent-Toddler Interaction – NEJM Journal Watch (free) AND Reading to Your Toddler? Print Books Are Better Than Digital Ones – The New York Times (10 articles per month are free)

The contribution of cannabis use to variation in the incidence of psychotic disorder across Europe (EU-GEI): a multicentre case-control study – The Lancet Psychiatry (free)

Commentaries: Cannabis and psychosis: triangulating the evidence – The Lancet Psychiatry (free) AND Expert reaction to daily cannabis use, potency and psychosis – Science Media Centre (free) AND Daily or high-potency cannabis increases risk of psychotic disorder, study finds – CNN (free) AND Daily cannabis and skunk users run higher psychosis risk – Reuters (free)

Psychosis with Methylphenidate or Amphetamine in Patients with ADHD – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Some ADHD medicines may increase psychosis more than others, ‘real-world’ data show – STAT (free) AND With ADHD, amphetamine has double the psychosis risk of methylphenidate – Reuters (free) AND Big data study identifies drugs that increase risk of psychosis in youth with ADHD – McLean Hospital (free)

Best Practices for Evaluation and Treatment of Agitated Children and Adolescents (BETA) in the Emergency Department: Consensus Statement of the American Association for Emergency Psychiatry – West Journal of Emergency Medicine (free)

Age, period, and cohort trends in mood disorder indicators and suicide-related outcomes in a nationally representative dataset, 2005–2017 – Journal of Abnormal Psychology (free PDF)

Commentaries: A Rise In Depression Among Teens And Young Adults Could Be Linked To Social Media Use – NPR (free) AND Mental health issues increased significantly in young adults over last decade – American Psychological Association (free)

Brazilian guidelines for the management of psychomotor agitation – Brazilian Journal of Psychiatry (free articles)

Part 1. Non-pharmacological approach

Part 2. Pharmacological approach

Guidelines for the Evaluation and Treatment of Perimenopausal Depression: Summary and Recommendations – Journal of Women’s Health (free)

Clinical Guidance on the Identification and Management of Treatment-Resistant Schizophrenia – The Journal of Clinical Psychiatry (free)

FDA approves new nasal spray medication for treatment-resistant depression; available only at a certified doctor’s office or clinic – U.S. Food & Drug Administration (free)

Commentaries: A ketamine-like drug is the first new antidepressant to get FDA approval in years: But it’s also controversial. – Vox (free) AND FDA Approves Intranasal Esketamine as Adjunctive Treatment for Depression – NEJM Journal Watch (free)

“But while some patient and doctor groups are hailing the approval, others aren’t so sure there’s enough evidence to justify it. That’s because the benefits of ketamine and esketamine aren’t yet well-understood. According to the FDA, the drug has only been studied in four clinical trials, three of them lasting just four weeks. And the results were pretty mixed.” (from Vox)

Related Commentary on Twitter

#FDA never learns from its past mistakes.
20 yrs ago, approved #Oxycontin, supposedly w restrictions.
We know how well those safety checks worked.
Now same blindness to risks of promoting #esketamine.
Doesnt it know people with #Depression will self medicate with street Special K https://t.co/FEj8S4QIFw

— Allen Frances (@AllenFrancesMD) March 6, 2019

Treatment of Anorexia Nervosa—New Evidence-Based Guidelines – Journal of Clinical Medicine (free)

Long work hours, weekend working and depressive symptoms in men and women: findings from a UK population-based study – Journal of Epidemiology & Community Health (free)

Commentaries: Working long hours linked to depression in women – University College London (free) AND Long Works Hours May Hike Depression Risk in Women – PsychCentral (free) AND Are women who work long hours more likely to be depressed? – NHS (free)

Benefits of Sequentially Adding Cognitive-Behavioral Therapy or Antidepressant Medication for Adults With Nonremitting Depression – The American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Patients Not Fully Responsive to Antidepressants, CBT Alone Found to Improve With Combined Therapies – Psychiatric News Alert (free) AND What to Do When Depression Doesn’t Remit with Monotherapy – NEJM Journal Watch (free for a limited period)

Best Practices for Evaluation and Treatment of Agitated Children and Adolescents (BETA) in the Emergency Department: Consensus Statement of the American Association for Emergency Psychiatry – West Journal of Emergency Medicine (free PDF)

Related Guideline: Evaluation and Management of Children and Adolescents With Acute Mental Health or Behavioral Problems. Part I: Common Clinical Challenges of Patients With Mental Health and/or Behavioral Emergencies – Pediatrics (free)

Pharmacological treatments for generalised anxiety disorder: a systematic review and network meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentary: Pharmacotherapy for Generalized Anxiety: An Update – NEJM Journal Watch (free for a limited period)

Predictive Validity of a 2-Question Alcohol Screen at 1-, 2-, and 3-Year Follow-up – Pediatrics (free)

Commentaries: Alcohol Use Disorder: A Pediatric-Onset Condition Needing Early Detection and Intervention – Pediatrics (free) AND 2-Question Screen Identifies Adolescents at Risk for Future Alcohol Use Disorders – 2 Minute Medicine (free)

#140 Psychopharmacology 2.0, Antidepressant Master Class – The Curbsiders Internal Medicine Podcast (free)

Deprescribing benzodiazepine receptor agonists taken for insomnia: a review and key messages from practice guidelines – Polish Archives of Internal Medicine (free PDF)

Related: Guideline: Deprescribing Benzodiazepines (free guideline and resources) AND Position Statement: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

Interesting in learning more about deprescribing benzodiazepines and Z-drugs? Check out our review just published at: https://t.co/aOB40uwFGM. A collaborative effort by members of @GERAScentre @MacDeptMed @HEI_mcmaster @ResearchStJoes @bruyerecare pic.twitter.com/BrwmhM1y1p

— Justin Lee (@JustinLeeMD) February 14, 2019

Association of Behavior in Boys From Low Socioeconomic Neighborhoods With Employment Earnings in Adulthood – JAMA Pediatrics (free for a limited period)

Commentaries: Inattention in Low-Income Boys Tied to Lesser Earnings in Adulthood – PsychCentral (free) AND Low-income boys’ inattention in kindergarten associated with lower earnings 30 years later – Carnegie Mellon University (free) AND Behavior at Age 6 May Predict Adult Income – The New York Times (10 articles per month are free)

Association of Cannabis Use in Adolescence and Risk of Depression, Anxiety, and Suicidality in Young Adulthood: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)

Commentary: Expert reaction to cannabis use in adolescents and risk of depression, anxiety and suicidality – Science Media Centre (free) AND Increased depression and suicidal behavior risk for young cannabis users – McGill University Health Centre (free) AND Cannabis smoking in teenage years linked to adulthood depression – The Guardian (free) AND Teen cannabis use linked to higher risk of adolescent depression – Reuters (free)

Interventions to Prevent Perinatal Depression: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Implementing the USPSTF Recommendations on Prevention of Perinatal Depression—Opportunities and Challenges (free) AND Perinatal Depression: Recommendations for Prevention and the Challenges of Implementation (free) AND Attention to Prevention—Can We Stop Perinatal Depression Before it Starts? (free)

Author Interview: USPSTF Recommendation: Interventions to Prevent Perinatal Depression (free audio)

Commentaries: Depression During and After Pregnancy Can Be Prevented, National Panel Says. Here’s How. – The New York Times (10 articles per month are free) AND To Prevent Pregnancy-Related Depression, At-Risk Women Advised To Get Counseling – NPR (free)

“The USPSTF recommends that clinicians provide or refer pregnant and postpartum persons who are at increased risk of perinatal depression to counseling interventions. (B recommendation)”

Association of the Youth-Nominated Support Team Intervention for Suicidal Adolescents With 11- to 14-Year Mortality Outcomes: Secondary Analysis of a Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Fewer Deaths Seen Among Young Adults Who Got Extra Adult Support as Suicidal Teens – Michigan Medicine (free) AND Intervention for Suicidal Adolescents May Reduce Long-Term Mortality – Psychiatric News Alert (free)

The effects of dietary improvement on symptoms of depression and anxiety: a meta-analysis of randomized controlled trials – Psychosomatic Medicine (free PDF)

Commentaries: Improved Diet Can Ease Depression Symptoms, Enhance Mood – PsychCentral (free) AND Many Different Diets Can Improve Mood And Reduce Depression Symptoms, Study Finds – Forbes (free) AND A diet rich in fiber and vegetables can relieve depression – Medical News Today (free)

Lettuce be happy: A longitudinal UK study on the relationship between fruit and vegetable consumption and well-being – Social Science & Medicine (free)

Commentary: Hearts and minds: fruit and veg boost well-being – University of Leeds (free) AND Eating more fruit and veg ‘improves mental wellbeing’ – NHS Choices (free)

Hallucinations in Children and Adolescents: An Updated Review and Practical Recommendations for Clinicians – Schizophrenia Bulletin (free)

Managing Antidepressant Discontinuation: A Systematic Review – Annals of Family Medicine (free)

Commentary: Psychotherapy Ups Odds of Tapering Off Antidepressants – Medscape (free registration required)

Global, regional, and national burden of suicide mortality 1990 to 2016: systematic analysis for the Global Burden of Disease Study 2016 – The BMJ (free)

Editorial: Suicide falls by a third globally (free for a limited period)

Commentaries: Global suicide mortality: Using data to inform action and monitor progress – The BMJ Opinion (free) AND Global rates of suicide death have fallen by a third since 1990, study finds – CNN (free)

Patterns in Outpatient Benzodiazepine Prescribing in the United States – JAMA Network Open (free)

Commentary: Steep Climb In Benzodiazepine Prescribing By Primary Care Doctors – NPR (free)

Related: A Quiet Drug Problem Among the Elderly – The New York Times (10 articles per month are free) AND Benzodiazepines: our other prescription drug epidemic – STAT (free)

Effect of aerobic exercise on cognition in younger adults: A randomized clinical trial – Neurology (link to abstract – $ for full-text)

Commentary: Exercise may improve thinking skills in people as young as 20 – American Academy of Neurology (free)

Clinical guidelines for the management of depression with specific comorbid psychiatric conditions French recommendations from experts (the French Association for Biological Psychiatry and Neuropsychopharmacology and the fondation FondaMental) – BMC Psychiatry (free)

Related Guideline: Depression in adults: recognition and management – National Institute for Health and Care Excellence (free)

Depression and coronary heart disease: 2018 ESC position paper of the working group of coronary pathophysiology and microcirculation developed under the auspices of the ESC Committee for Practice Guidelines – European Heart Journal (free)

This Is Your Brain Off Facebook – The New York Times (10 articles per month are free)

Original randomized trial, involving nearly 3000 individuals: The Welfare Effects of Social Media (free PDF)

“Expect the consequences to be fairly immediate: More in-person time with friends and family. Less political knowledge, but also less partisan fever. A small bump in one’s daily moods and life satisfaction. And, for the average Facebook user, an extra hour a day of downtime.”

Prevalence of Cannabis Use Among Medical Students: A Systematic Review and Meta-analysis – Substance Abuse: Research and Treatment (free)

“1 in 3 medical students has used cannabis, whereas 8.8% were current users”

The digital drug: Internet addiction spawns U.S. treatment programs – Reuters (free)

Related: Gaming disorder – World Health Organization (free) AND Gaming addiction classified as mental health disorder by WHO – Reuters (free) AND WHO classifies ‘gaming disorder’ as mental health condition – CNN (free) AND Do You Have ‘Gaming Disorder,’ A Newly Recognized Mental Health Condition? – Forbes (free) AND Endless Gaming May Be a Bad Habit. That Doesn’t Make It a Mental Illness – The New York Times (10 articles per month are free) AND Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free) AND Is ‘Internet Addiction’ Real? – NPR Health News (free)

Association Between Screen Time and Children’s Performance on a Developmental Screening Test – JAMA Pediatrics (free for a limited period)

Commentaries: Expert reaction to study on use of screen time and child development – Science Media Centre (free) AND Too much toddler screen time tied to worse social, motor skills by kindergarten – Reuters (free) AND More screen time for toddlers is tied to poorer development a few years later, study says – CNN (free) AND Screen time ‘may harm toddlers’ – BBC (free) AND Screen time predicts delays in child development, says new research – The Conversation (free)

Related Guidelines: Media devices in pre-school children: the recommendations of the Italian pediatric society – Italian Journal of Pediatrics (free) AND Media and Young Minds – Recommendations from The American Academy of Pediatrics (free)

See also: Children, Adolescents and Screens: What We Know and What We Need To Learn (Pediatrics Supplement with free articles)

Aerobic exercise for adult patients with major depressive disorder in mental health services: A systematic review and meta‐analysis – Depression & Anxiety (free)

Commentary: Aerobic exercise is an effective treatment for depression – NIHR Signal (free)

Related Study: Assessment of Bidirectional Relationships Between Physical Activity and Depression Among Adults: A 2-Sample Mendelian Randomization Study – JAMA Psychiatry (link to abstract – $ for full-text) AND Commentary: Exercise can reduce risk for depression, research shows – UPI (free)

Association of Hydroxylmethyl Glutaryl Coenzyme A Reductase Inhibitors, L-Type Calcium Channel Antagonists, and Biguanides With Rates of Psychiatric Hospitalization and Self-Harm in Individuals With Serious Mental Illness – JAMA Psychiatry (free)

Commentaries: Can Some Common Drugs Also Benefit Mental Health? – PsychCentral (free) AND 3 common drugs associated with reduced risk of hospitalization and harm in serious mental illness – ACP Internist (free)

Hospital Observation Upon Reversal (HOUR) With Naloxone: A Prospective Clinical Prediction Rule Validation Study – Academic Emergency Medicine (free)

Commentary: Study confirms 1-hour discharge rule for patients given naloxone after opiate overdose – Society for Academic Emergency Medicine (free)

Association of Pharmaceutical Industry Marketing of Opioid Products With Mortality From Opioid-Related Overdoses – JAMA Network Open (free)

Editorial: A Perspective Regarding the Current State of the Opioid Epidemic (free)

Author Interview: Marketing of Opioid Products and Mortality From Opioid-Related Overdoses; Comparison of Wait Times for New Patients Between the Private Sector and VA Medical Centers (free)

Commentaries: Study Links More Marketing Of Opioids To More Overdose Deaths – CommonHealth (free) AND Heavy marketing of opioid drugs linked to overdose deaths – UPI (free) AND Study Links Drug Maker Gifts for Doctors to More Overdose Deaths – The New York Times (10 articles per month are free)

Medscape National Physician Burnout, Depression & Suicide Report 2019 (free registration required)

Commentaries: Burnout Rises Above 50% in Some Specialties, New Survey Shows – Medscape (free registration required) AND No quick fix for physician burnout, depression – Reuters (free) AND More than half of physicians are burned out or depressed – HealthExec (free)

Related Perspectives: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free) AND The Burnout Crisis in American Medicine – The Atlantic (free) AND Implementing Optimal Team-Based Care to Reduce Clinician Burnout – National Academy of Medicine (free) AND Physician burnout costs up to $17B a year, task force says – HealthcareDive (free)

Related Articles: Physician Burnout Can Lead to Major Medical Errors (link to abstract and commentaries) AND Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction (link to abstract and commentaries) AND Systematic Review: Prevalence of Burnout Among Physicians (link to abstract and commentaries)

Alcohol use and dementia: a systematic scoping review – Alzheimer’s Research & Therapy (free)

Excess Burden of Mental Illness and Hospitalization in Young-Onset Type 2 Diabetes: A Population-Based Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Mental Illness Risk Increased in Young Onset Diabetes – MedicalResearch.com (free) AND Young-onset type 2 diabetes associated with increased risk of hospitalization frequently due to mental illness – 2 Minute Medicine (free) AND Young Onset Diabetes Linked to High Rates of Mental Illness, Hospitalization – AJMC (free)

Benzodiazepines or related drugs and risk of pneumonia: A systematic review and meta‐analysis – International Journal of Geriatric Psychiatry (free)

Commentary: Benzodiazepines May Boost Pneumonia Risk, Especially in Seniors – Medscape (free registration required)

The association between adolescent well-being and digital technology use – Nature Human Behavior (link to abstract – $ for full-text)

Commentaries: Technology use explains at most 0.4 percent of adolescent wellbeing, new study finds – University of Oxford (free) AND Expert reaction to adolescent well-being and digital technology use – Science Media Centre (free) AND Screen Time May Be No Worse For Kids Than Eating Potatoes – Forbes (free)

Royal Australian and New Zealand College of Psychiatrists clinical practice guidelines for the treatment of panic disorder, social anxiety disorder and generalised anxiety disorder – Australian & New Zealand Journal of Psychiatry (free)

Suicide among cancer patients – Nature Communications (free)

Commentary: Suicide risk more than quadruples for people with cancer – Penn State (free)

Related Research: Suicidal death within a year of a cancer diagnosis (free study and commentary) AND Risk of Suicide After Cancer Diagnosis in England (free study and commentary)

The effectiveness of art therapy for anxiety in adults: A systematic review of randomised and non-randomised controlled trials – PLOS One (free)

Suicidal death within a year of a cancer diagnosis: A population‐based study – Cancer (free)

Commentary: Suicide risk increases significantly following a cancer diagnosis – Wiley (free)

Related Research: Risk of Suicide After Cancer Diagnosis in England (free study and commentary)

Social Media Use and Adolescent Mental Health: Findings From the UK Millennium Cohort Study – EClinicalMedicine (free)

Commentaries: Social media is more detrimental to girls’ mental health than for boys’ – News Medical (free) AND Depression in girls linked to higher use of social media – The Guardian (free)

Related Research: Gender differences in the associations between age trends of social media interaction and well-being among 10-15 year olds (free study and commentaries)

Ask Suicide-Screening Questions (ASQ) Toolkit – National Institute of Mental Health (free)

Commentary: New pathways for implementing universal suicide risk screening in healthcare settings – NIH News Releases (free)

AAP Policy Statement: Incorporating Recognition and Management of Perinatal Depression Into Pediatric Practice – Pediatrics (free)

Related Technical Report: Incorporating Recognition and Management of Perinatal Depression Into Pediatric Practice – Pediatrics (free)

Different Types and Acceptability of Psychotherapies for Acute Anxiety Disorders in Children and Adolescents: A Network Meta-analysis – JAMA Psychiatry (free)

Commentaries: Group therapy most effective treatment for anxiety in young people – University of Oxford (free) AND Meta-Analysis Finds Group CBT Optimal Psychotherapy for Children, Adolescents With Anxiety – Psychiatric News Alert (free)

Driving with Dementia or Mild Cognitive Impairment: Consensus Guidelines for Clinicians – Royal College of Psychiatrists (free PDF)

Commentary: When should dementia patients stop driving? A new guidance for clinicians – Newcastle University (free)

Drugs Most Frequently Involved in Drug Overdose Deaths: United States, 2011–2016 – Centers for Disease Control and Prevention (free PDF)

Commentary: CDC: Top 10 Drugs Involved in Drug Overdose Deaths – MPR (free)

Post-traumatic stress disorder – National Institute for Health and Care Excellence (free)

Effects of fluoxetine on functional outcomes after acute stroke (FOCUS): a pragmatic, double-blind, randomised, controlled trial – The Lancet (free)

Commentaries: Fluoxetine and recovery after stroke – The Lancet (free) AND Fluoxetine (Prozac) Did Not Reduce Risk of Depression After Stroke, But Did Raise Risk of Fractures – MedicalResearch.com (free) AND Common antidepressant does not aid stroke recovery, study finds – University of Edinburgh (free)

Increased Risk of Metabolic Syndrome in Antidepressants Users: A Mini Review – Frontiers in Psychiatry (free)

Topiramate and Metformin Are Effective Add-On Treatments in Controlling Antipsychotic-Induced Weight Gain: A Systematic Review and Network Meta-Analysis – Frontiers in Pharmacology (free)

Association of Primary Care Consultation Patterns With Early Signs and Symptoms of Psychosis – JAMA Network Open (free)

Commentaries: Identifying Risk of Psychosis in a Primary Care Setting – JAMA Network Open (free) AND Spotting patients at risk for psychosis: 12 high-risk symptoms – Univadis (free registration required)

Potential Risks and Benefits of Mental Health Screening of Physicians – JAMA (free for a limited period)

Is It Possible to Predict the Future in First-Episode Psychosis? – Frontiers in Psychiatry (free)

The Challenges of Improving Treatments for Depression – JAMA (free)

Risk of Suicide After Cancer Diagnosis in England – JAMA Psychiatry (free)

Commentaries: Cancer Diagnosis Associated with Increased Suicide Risk – NEJM Journal Watch (free)

Attention Deficit–Hyperactivity Disorder and Month of School Enrollment – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: When starting school, younger children are more likely to be diagnosed with ADHD – Harvard Medical School (free) AND Youngest Children In A Class Are Most Likely To Get ADHD Diagnosis – NPR (free) AND Younger school entry could set stage for ADHD diagnosis – Associated Press (free)

Related: Systematic Review: Youngest in Class More Likely to be Diagnosed with ADHD (free study and commentaries)

Is our constant use of digital technologies affecting our brain health? We asked 11 experts – VOX (free)

Comparative risk of harm associated with trazodone or atypical antipsychotic use in older adults with dementia: a retrospective cohort study – Canadian Medical Association Journal (free)

Commentaries: Study finds alternative to antipsychotic medication for seniors also has drawbacks – The Globe and Mail (free) AND Trazadone linked to more falls, major fractures in dementia patients – UPI (free) AND Trazadone associated with similar risk of falls and major fractures as antipsychotics in seniors with dementia – Canadian Medical Association Journal (free) AND Aggression in Dementia: Alternatives to Antipsychotics Also Have Side Effects – MedicalResearch.com (free)

Anxiety, Depression and Post Traumatic Stress Disorder after critical illness: a UK-wide prospective cohort study – Critical Care (free)

Commentaries: Over half of former ICU patients in the UK report symptoms of psychological disorders – BioMed Central (free) AND ICU stay can lead to depression – Reuters (free)

A systematic review of the next‐day effects of heavy alcohol consumption on cognitive performance – Addiction (free)

Lifestyle Interventions and Prevention of Suicide – Frontiers in Psychiatry (free)

A systematic review and meta‐analysis of lifestyle interventions in women of reproductive age with overweight or obesity: the effects on symptoms of depression and anxiety – Obesity Reviews (free)

Effects of the Learning Together intervention on bullying and aggression in English secondary schools (INCLUSIVE): a cluster randomised controlled trial – The Lancet (free)

Invited Commentary: Changing school climates to promote adolescent wellbeing: two trials with one goal (free)

Selective serotonin reuptake inhibitor use during early pregnancy and congenital malformations: a systematic review and meta-analysis of cohort studies of more than 9 million births – BMC Medicine (free)

Associations Between Breast Cancer Survivorship and Adverse Mental Health Outcomes: A Systematic Review – JNCI: Journal of the National Cancer Institute (free)

Commentary: Adverse Mental Health Outcomes in Breast Cancer Survivors – The ASCO Post (free)

“There is compelling evidence of an increased risk of anxiety, depression and suicide, and neurocognitive and sexual dysfunctions in breast cancer survivors compared with women with no prior cancer.”

Depression, antidepressants, and the risk of non-valvular atrial fibrillation: A nationwide Danish matched cohort study – European Journal of Preventive Cardiology (free)

Commentary: Depressed people have an increased risk of atrial fibrillation – European Society of Cardiology (free) AND Study: Depressed patients see up to 7-fold higher risk for AFib – Cardiovascular Business (free)

Association of Concussion with the Risk of Suicide: A Systematic Review and Meta-Analysis – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Concussions tied to doubled risk of suicide – Reuters (free) AND Suicide Risk Doubles After Concussion – Medscape (free registration required)

Replication failures in psychology not due to differences in study populations – Nature (free)

See also: 28 classic and contemporary psychology findings replicated in more than 60 laboratories each across three dozen nations and territories – Centers for Open Science (free)

Related: Evaluating the Replicability of Social Science Experiments (link to abstract and commentaries) AND Essay: The Experiments Are Fascinating. But Nobody Can Repeat Them – The New York Times (10 articles per month are free)

Updated European Consensus Statement on diagnosis and treatment of adult ADHD – European Psychiatry (free)

Treating PTSD: A Review of Evidence-Based Psychotherapy Interventions – Frontiers in Behavioral Neuroscience (free)

No More FOMO: Limiting Social Media Decreases Loneliness and Depression – Journal of Social and Clinical Psychology (free PDF)

Commentary: Is Social Media Making You Depressed and Lonely? – MedicalResearch.com (free)

Lithium and nephrotoxicity: a literature review of approaches to clinical management and risk stratification – BMC Nephrology (free)

Screening and Behavioral Counseling Interventions to Reduce Unhealthy Alcohol Use in Adolescents and Adults: US Preventive Services Task Force Recommendation Statement – JAMA (free)

Editorials: Screening for Unhealthy Alcohol Use (free) AND Unhealthy Alcohol Use in Primary Care—The Elephant in the Examination Room (free)

Author Interview: USPSTF Recommendation: Screening and Interventions for Unhealthy Alcohol Use (free audio)

JAMA Patient Page: Screening and Counseling to Reduce Unhealthy Alcohol Use (free)

Antipsychotic drug use and pneumonia: Systematic review and meta-analysis – Journal of Psychopharmacology (link to abstract – $ for full-text)

Commentary: Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests – Psychiatric News Alert (free)

“Although antipsychotic use was associated with a higher risk of pneumonia, the researchers stopped short of claiming causality, citing a lack of data from randomized, controlled trials and a failure of observational studies to control for relevant confounders like tobacco use and weight.” (from Psychiatric News Alert)

Perioperative alcohol cessation intervention for postoperative complications – Cochrane Library (free)

Summary: Effects of perioperative alcohol cessation interventions on postoperative complications following surgery – Cochrane Library (free)

“Intensive alcohol cessation interventions offered for four to eight weeks to participants undergoing all types of surgical procedures to achieve complete alcohol cessation before surgery probably reduced the number of postoperative complications.”

Guideline: Management of physical health conditions in adults with severe mental disorders – World Health Organization (free PDF)

News Release: WHO guidelines: Management of physical health conditions in adults with severe mental disorders (free)

WHO Video: Improving the physical health of people with severe mental disorders (free)

One Month of Cannabis Abstinence in Adolescents and Young Adults Is Associated With Improved Memory – Journal of Clinical Psychiatry (link to abstract – $ for full-text)

Commentaries: When Adolescents Give Up Pot, Their Cognition Quickly Improves – NPR (free) AND Stopping Cannabis Tied to Memory Improvements – NEJM Journal Watch (free)

What Works in Youth Suicide Prevention? A Systematic Review and Meta-Analysis – EclinicalMedicine (free)

Related: 800,000 People Kill Themselves Every Year. What Can We do? (free Guidelines and commentary) AND Recommended Standard Care for People with Suicide Risk (free Guideline and commentary) AND Preventing Teen Suicide: What Does the Evidence Shows (free Guideline and commentary) AND AAP Clinical Report: Suicide and Suicide Attempts in Adolescents (free)

Associations between screen time and lower psychological well-being among children and adolescents: Evidence from a population-based study – Preventive Medicine Reports (free)

Commentary: Reduced screen time for young highly recommended for well-being – San Diego State University (free)

The global burden of disease attributable to alcohol and drug use in 195 countries and territories, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Psychiatry (free)

Invited Commentary: New data to support much needed policy change (free)

Effect of Internet-Based Cognitive Behavioral Humanistic and Interpersonal Training vs Internet-Based General Health Education on Adolescent Depression in Primary Care: A Randomized Clinical Trial – JAMA Network Open (free)

Commentary: Online program helps prevent teen depression – University of Illinois at Chicago (free)

Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: E-therapy may help ease insomnia – Reuters (free) AND Some Apps May Help Curb Insomnia, Others Just Put You To Sleep – NPR (free) AND Insomnia symptoms, overall health improve with online insomnia program – Northwestern University (free)

Systematic review and guide to management of core and psychiatric symptoms in youth with autism – Acta Psychiatrica Scandinavica (free)

Assessment and Management of Cognitive and Psychosocial Dysfunctions in Patients With Major Depressive Disorder: A Clinical Review – Frontiers in Psychiatry (free)

Mirtazapine added to SSRIs or SNRIs for treatment resistant depression in primary care: phase III randomised placebo controlled trial (MIR) – The BMJ (free)

Commentary: Popular drug combination for treatment resistant depression is not more effective than a single antidepressant in primary care – University of Bristol (free)

Haloperidol and Ziprasidone for Treatment of Delirium in Critical Illness – New England Journal of Medicine (free for a limited period)

Editorial: Dopamine Antagonists in ICU Delirium (free for a limited period)

Commentaries: Common use of antipsychotics shown ineffective for delirium in intensive care patients – NIH News Releases (free) AND Antipsychotic Drugs Don’t Ease ICU Delirium Or Dementia – NPR (free) AND Antipsychotics ineffective for treating ICU delirium – Vanderbilt University Medical Center (free)

Related Research: Effect of Haloperidol on Survival Among Critically Ill Adults With a High Risk of Delirium (free)

How early media exposure may affect cognitive function: A review of results from observations in humans and experiments in mice – Proceedings of the National Academy of Sciences (free)

Related Article: Screen media use and ADHD-related behaviors: Four decades of research – Proceedings of the National Academy of Sciences (free)

Antidepressant withdrawal: reviewing the paper behind the headlines – The Mental Elf (free) (via @AllenFrancesMD)

Original Systematic Review: Antidepressant Withdrawal Effects (free article and commentaries)

“Last week a new review said: – Over half of people taking antidepressants experience withdrawal symptoms – These symptoms are severe in over half of cases. The press had a field day! Our blog today by @J_F_Hayes and @sameerjauhar offers a different view” (via @Mental_Elf see Tweet)

Demystifying serotonin syndrome (or serotonin toxicity) – Canadian Family Physician (free)

Attention deficit hyperactivity disorder late birthdate effect common in both high and low prescribing international jurisdictions: systematic review – The Journal of Child Psychology and Psychiatry (free) (via @AllenFrancesMD)

Commentary: Global study finds youngest in class more likely to be diagnosed with ADHD – University of Adelaide (free)

Association of Depression With Risk of Incident Systemic Lupus Erythematosus in Women Assessed Across 2 Decades – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Depression May Increase Risk of Developing an Autoimmune Disease – MedicalResearch.com (free) AND Depression Tied to Double the Risk for Lupus in Women – Medscape (free registration required)

The Lancet Commission on global mental health and sustainable development (free registration required)

Commentaries: Mental health crisis could cost the world $16 trillion by 2030 – Reuters (free) AND Mental health disorders will cause ‘monumental suffering’ and cost £12 TRILLION a year worldwide by 2030 – The Daily Mail (free) AND World in mental health crisis of ‘monumental suffering’, say experts – The Guardian (free)

800,000 people kill themselves every year. What can we do? – The Guardian (free) (via @onisillos)

Related Guidelines: Preventing suicide: A community engagement toolkit – World Health Organization (free PDF) AND Preventing suicide in community and custodial settings – National Institute for Health and Care Excellence (free)

“In too many places mental health support services are non-existent and those with treatable conditions are criminalized. Bold action is long overdue”

The Diagnosis and Treatment of Anxiety Disorders – Deutsches Ärzteblatt international (free)

A Population-Based Analysis of the Relationship Between Substance Use and Adolescent Cognitive Development – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentaries: Teen cannabis use is not without risk to cognitive development – Université de Montréal (free) AND Cannabis ‘more harmful than alcohol’ for teen brains – BBC (free)

A systematic review into the incidence, severity and duration of antidepressant withdrawal effects: Are guidelines evidence-based? – Addictive Behaviours (free PDF)

Commentaries: Antidepressant withdrawal ‘hits millions’ – BBC (free) AND Antidepressant withdrawal symptoms severe, says new report – The Guardian (free)

Related: Antidepressant Withdrawal Syndrome (free review and NYT article)

WHO launches SAFER alcohol control initiative to prevent and reduce alcohol-related death and disability – World Health Organization (free)

See also: SAFER High Impact Strategies (free)

Related: WHO Global Status Report on Alcohol and Health 2018 (free report and commentaries)

Associations between 24 hour movement behaviours and global cognition in US children: a cross-sectional observational study – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)

Commentaries: Limiting children’s recreational screen time to less than 2 hours a day linked to better cognition – The Lancet (free) AND Limiting children’s screen time linked to better cognition, study says – CNN (free) AND Limiting children’s screen time linked to better cognition – BBC (free)

“Researchers said more work was now needed to better understand the effects of different types of screen use. However, they acknowledge that their observational study shows only an association between screen time and cognition and cannot prove a causal link.” (from BBC)

Effect of Digital Cognitive Behavioral Therapy for Insomnia on Health, Psychological Well-being, and Sleep-Related Quality of Life: A Randomized Clinical Trial – JAMA Psychiatry (free for a limited period) (via @EricTopol)

Commentary: Insomnia symptoms, overall health improve with online insomnia program – Northwestern University (free)

Healthy dietary indices and risk of depressive outcomes: a systematic review and meta-analysis of observational studies – Molecular Psychiatry (link to abstract – $ for full-text)

Commentaries: Plant-rich diets may help prevent depression – new evidence – The Conversation (free) AND Eating a Mediterranean diet ‘may lower your risk of depression’ – NHS Choices (free) AND Expert reaction to observational studies on diet and depression – Science Media Centre (free) AND Mediterranean diet could prevent depression, new study finds – CNN (free)

“The current evidence is not sufficient to prove plant-rich diets can prevent depression as most of the evidence so far simply shows that those with poorer mental health eat worse, so it may be that those more prone to depression also choose less health” (from CNN)

#115 Geriatric Depression – The Curbsiders Internal Medicine Podcast (free)

Summary: #115 Geriatric Depression: Diagnosis, Antidepressants, and More (free)

Global status report on alcohol and health 2018 – World Health Organization (free PDF)

News Release: Harmful use of alcohol kills more than 3 million people each year, most of them men (free)

Commentaries: Alcohol abuse kills 3 million a year, most of them men: WHO – Reuters (free) AND 1 in 20 deaths globally is a result of alcohol use – CNN (free) AND Alcohol causes one in 20 deaths worldwide, says WHO – The Guardian (free)

The cost of persuasive design: digital media use and ADHD – The Mental Elf (free)

Original Study: Association of Digital Media Use with ADHD Among Adolescents (link to abstract and free commentaries)

Prevalence of Burnout Among Physicians: A Systematic Review – JAMA (link to abstract – $ for full-text)

Commentaries: Doctors Today May Be Miserable, But Are They ‘Burnt Out’? – NPR (free) AND Physician burnout taking center stage – Reuters (free) AND Burnout Found to Be Common Among U.S. Resident Physicians – Psychiatric News Alert (free)

Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians (free) AND The Burnout Crisis in American Medicine – The Atlantic (free) AND To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record (free commentaries)

Implementing Optimal Team-Based Care to Reduce Clinician Burnout – National Academy of Medicine (free)

Commentaries: Optimal team-based health care is associated with improved patient outcomes and physician well-being – ACP Newsroom (free) AND New Review Shows Team-Based Care May Reduce Physician Burnout – Medscape (free registration required)

Factors Associated With Long-term Benzodiazepine Use Among Older Adults – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: 1 in 4 Older Adults Prescribed a Benzodiazepine Goes on to Risky Long-Term Use, Study Finds – Michigan Medicine, via NewsWise (free) AND Long-Term Benzodiazepine Use Common Among Older Adults – Physician’s First Watch (free) AND Factors Predicting Long-term Benzodiazepine Use Identified – Medscape (free registration required) AND Larger Number of Benzodiazepine Pills in Initial Prescription Associated With Long Term Use – MedicalResearch.com (free)

Related: A Quiet Drug Problem Among the Elderly – The New York Times (free) AND Our Other Prescription Drug Problem – New England Journal of Medicine (free) AND Benzodiazepines: our other prescription drug epidemic – STAT (free) AND Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free)

How well do you know your anticholinergic (antimuscarinic) drugs? – Therapeutics Initiative (free)

Preventing suicide A community engagement toolkit – World Health Organization (free PDF)

Fact Sheet: Suicide – World Health Organization(free)

Preventing suicide in community and custodial settings – National Institute for Health and Care Excellence (free)

Chronic Pain Among Suicide Decedents, 2003 to 2014: Findings From the National Violent Death Reporting System – Annals of Internal Medicine (free)

Editorial: Pain, Opioids, and Suicide Mortality in the United States (free)

Commentaries: Chronic pain may contribute to suicide, study warns – Reuters(free) ANDChronic Pain Tied to Increased Suicide Risk – NEJM Physician’s First Watch(free) AND Increasing rates of chronic pain found among those who die by suicide – ACP Internist(free)

Preventing Cognitive Decline in Black Individuals With Mild Cognitive Impairment: A Randomized Clinical Trial – JAMA Neurology (free for a limited period)

Commentary: Study provides evidence to prevent memory decline in older blacks with mild cognitive impairment – News Medical (free) AND Novel Intervention Markedly Slows Cognitive Decline in MCI – Medscape (free registration required)

Guidelines for the Evaluation and Treatment of Perimenopausal Depression: Summary and Recommendations – Journal of Women’s Health (free)

Commentaries: First-Ever Guidelines for Detecting, Treating Perimenopausal Depression – University of Illinois at Chicago, via NewsWise (free) AND Guidelines for Managing Perimenopausal Depression Now Available – MPR (free)

Antidepressants for treating depression in dementia – Cochrane Library (free for a limited period)

Summary: Antidepressants for treating depression in dementia – Cochrane Library (free)

“On the only measure of efficacy for which we had high-quality evidence (depression rating scale scores), antidepressants showed little or no effect.”

Evaluating the replicability of social science experiments in Nature and Science between 2010 and 2015 – Nature Human Behavior (free for a limited period)

Commentaries: More social science studies just failed to replicate. Here’s why this is good – VOX (free) AND High-profile journals put to reproducibility test – Nature News (free) AND ‘Replication crisis’ spurs reforms in how science studies are done – ScienceNews (free) AND The Science Behind Social Science Gets Shaken Up—Again – WIRED (Free) AND In Psychology And Other Social Sciences, Many Studies Fail The Reproducibility Test – NPR (free)

“We replicated 21 social science experiments in Science or Nature. We succeeded with 13. Replication effect sizes were half of originals.” (via @BrianNosek see Tweet)

Psychological Distress and Risk of Myocardial Infarction and Stroke in the 45 and Up Study: A Prospective Cohort Study – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Distress boosts heart attack and stroke risk – Medical News Today (free) AND High Mental Distress Tied to Heart Troubles – MedPage Today (free registration required)

Exploring the Relationship Between Depression and Dementia – JAMA (free for a limited period)

Pregabalin and the Risk for Opioid-Related Death: A Nested Case–Control Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Pregabalin may increase the risk of death when coprescribed with opioids – 2 Minute Medicine (free) AND Pregabalin Linked To Increased Risk for Opioid-Related Deaths – MedicalResearch.com (free) AND Anticonvulsant With Opioids Tied To Higher Mortality – MedPage Today (free registration required)

Optimising first- and second-line treatment strategies for untreated major depressive disorder — the SUND study: a pragmatic, multi-centre, assessor-blinded randomised controlled trial – BMC Medicine (free)

Association Between Traumatic Brain Injury and Risk of Suicide – JAMA (link to abstract – $ for full-text)

Commentaries: Traumatic brain injury tied to increased risk of suicide – Reuters (free) AND Risk of Suicide Increases After TBI, Study Finds – Psychiatric News Alert (free) AND Expert reaction to traumatic brain injury and suicide – Science Media Centre (free)

Amisulpride and olanzapine followed by open-label treatment with clozapine in first-episode schizophrenia and schizophreniform disorder (OPTiMiSE): a three-phase switching study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Switching Anti-Psychotic Medications Doesn’t Improve Outcomes in First-Episode Schizophrenia Patients – Mount Sinai (free) AND No Benefit of Switching Antipsychotics in Early Schizophrenia – Medscape (free registration required) AND No Gain with Antipsych Meds Switch in Schizophrenia – MedPage Today (free registration required)

Opioid prescribing decreases after learning of a patient’s fatal overdose – Science (free for a limited period)

Commentary: Notification of patient overdose deaths reduces clinician opioid prescriptions – NIH News Releases (free) AND Clinicians were told their patient had died of an overdose. Then opioid prescribing dropped – STAT (free)

Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis – The Lancet Psychiatry (free)

Commentaries: Refining treatment choices for ADHD – The Lancet Psychiatry (free) AND ADHD medications: Of all available drugs, methylphenidate should be first option for short-term treatment in children – ScienceDaily (free) AND Analysis of ADHD Drugs: Use Methylphenidate in Kids, Amphetamines in Adults – Physician’s First Watch (free)

Related: Cochrane Review: Adverse Events of Methylphenidate for ADHD in Children and Adolescents (link to abstract and free summary) AND Short Review: Stimulants for ADHD in children (free) AND Opinion: Drug treatment of ADHD – tenuous scientific basis (free)

Are the “Best Buys” for Alcohol Control Still Valid? An Update on the Comparative Cost-Effectiveness of Alcohol Control Strategies at the Global Level – Journal of Studies on Alcohol and Drugs (free)

Commentary: Higher alcohol taxes are cost-effective in reducing alcohol harms – ScienceDaily (free)

Related: To improve global health, tax the things that are killing us – Financial Times (free policies, articles and commentaries) AND Policy lessons from health taxes (free research and commentaries)

Treatment for Bipolar Disorder in Adults: A Systematic Review – Agency for Healthcare Research and Quality (free)

See also: Full Report (free PDF) AND Evidence Summary (free PDF)

Association between physical exercise and mental health in 1·2 million individuals in the USA between 2011 and 2015: a cross-sectional study – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Expert reaction to physical activity linked to improved mental health – Science Media Centre (free) AND Regular exercise ‘best for mental health’ – BBC (free) AND Exercise is good for your body and your mind, study says – CNN (free)

Peer-supported self-management for people discharged from a mental health crisis team: a randomised controlled trial – The Lancet (free)

Commentaries: Peer-delivered self-management programmes in mental health – The Lancet (free) AND After the crisis: self-management and peer-support – The Mental Elf (free) AND Peer Support Helps Reduce Mental Crisis Readmissions – MedPage Today (free registration required)

The association between suicide deaths and putatively harmful and protective factors in media reports – Canadian Medical Association Journal (free) (via @IrfanDhalla)

Invited Commentary: Responsible reporting to prevent suicide contagion (free for 1 week)

Drinking or Smoking While Breastfeeding and Later Cognition in Children – Pediatrics (free)

Commentaries: Study: Drinking while breastfeeding linked with children’s reasoning deficits – AAP News (free) AND Alcohol in breast milk may lead to lower cognition in kids, study finds – CNN (free) AND Fuel For Mommy Shaming: Breastfeeding And Alcohol Study Deeply Misleading – Forbes (free)

A Systematic Review and Meta‐analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department – Academic Emergency Medicine (link to abstract – $ for full-text)

Commentaries: Low-Dose Ketamine Offers Effective Alternative to Opioids in Treatment of Acute Pain, Meta-Analysis Suggests – Psychiatric News Alert (free) AND Ketamine vs Opioids for Acute Pain in the Emergency Department – MedicalResearch.com (free) AND Low-Dose Ketamine May Be a Safe Opioid Alternative, Review Confirms – Medscape (free registration required) AND Ketamine could help reduce opioid use in the ER – Medical News Today (free)

Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Treating Depression May Improve Cardiac Outcomes, Research Finds – AJMC (free) AND Treating depression may prevent repeat heart attack, study says – UPI (free)

Prevalence of Depression Among Fathers at the Pediatric Well-Child Care Visit – JAMA Pediatrics (link to abstract – $ for full-text)

Commentaries: New dads need depression screening, too – Reuters (free) AND New Dads as Likely to Suffer From Depression as Moms, Study Suggests – Medscape (free registration required)

Physicians aren’t ‘burning out.’ They’re suffering from moral injury – STAT (free)

Related: The Burnout Crisis in American Medicine (free commentaries on the subject) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and free commentaries)