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Pharmacology/Pharmaceutical Industry

RCT: In patients with advanced esophageal squamous-cell carcinoma, both nivolumab plus chemotherapy and nivolumab plus ipilimumab resulted in longer overall survival than chemotherapy alone.

3 Feb, 2022 | 09:46h | UTC

Nivolumab Combination Therapy in Advanced Esophageal Squamous-Cell Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary (2021 ASCO Annual Meeting): Nivolumab Plus Chemotherapy and Nivolumab Plus Ipilimumab as First-Line Treatment for Patients With Advanced Esophageal Cancer – The ASCO Post

 

Commentary on Twitter

 

Cluster randomized controlled trial: An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients.

3 Feb, 2022 | 08:53h | UTC

An innovative telemedical network to improve infectious disease management in critically ill patients and outpatients: a stepped-wedge, cluster randomized controlled trial (TELnet@NRW) – Journal of Medical Internet Research

Related:

The “Choosing Wisely” initiative in infectious diseases – German Society of Infectious Diseases (link to abstract – $ for full-text)

Infectious Diseases Society of America: Five Things Physicians and Patients Should Question

 

Outpatient Therapies for COVID-19: How do we choose?

2 Feb, 2022 | 08:53h | UTC

Outpatient Therapies for COVID-19: How do we choose? – Open Forum Infectious Diseases

 

Updated NIH COVID-19 Treatment Guidelines: Therapeutic management of nonhospitalized adults with COVID-19.

2 Feb, 2022 | 08:50h | UTC

Therapeutic Management of Nonhospitalized Adults With COVID-19 – NIH COVID-19 Treatment Guidelines

 

Commentary on Twitter

 

Ten billion COVID vaccinations: world hits new milestone.

2 Feb, 2022 | 08:48h | UTC

Ten billion COVID vaccinations: world hits new milestone – Nature

 

Commentary on Twitter

 

M-A: Impact of Ketamine on analgosedative consumption in critically ill patients.

2 Feb, 2022 | 08:44h | UTC

Impact of Ketamine on Analgosedative Consumption in Critically Ill Patients: A Systematic Review and Meta-Analysis – Annals of Pharmacotherapy

Related:

RCT: Fentanyl vs. placebo with ketamine and rocuronium for patients undergoing rapid sequence intubation in the emergency department.

RCT: In patients undergoing emergency endotracheal intubation, 7-day survival was significantly lower with etomidate vs. ketamine (77.3% versus 85.1%), but 28 survival rates were not significantly different (etomidate 64.1% vs. ketamine 66.8%, p = 0.294).

 

Perspective: Avoidance of β-blockers in patients who use stimulants is not supported by good evidence.

2 Feb, 2022 | 08:39h | UTC

Avoidance of β-blockers in patients who use stimulants is not supported by good evidence – Canadian Medical Association Journal

 

Using melatonin for sleep is on the rise, study says, despite potential health harms.

2 Feb, 2022 | 08:41h | UTC

Using melatonin for sleep is on the rise, study says, despite potential health harms – CNN

Original Study: Trends in Use of Melatonin Supplements Among US Adults, 1999-2018 – JAMA (free for a limited period)

 

RCT: Safety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling.

2 Feb, 2022 | 08:34h | UTC

Safety and efficacy of agomelatine in children and adolescents with major depressive disorder receiving psychosocial counselling: a double-blind, randomised, controlled, phase 3 trial in nine countries – The Lancet Psychiatry (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: Efficacy and safety of Risankizumab for active psoriatic arthritis.

2 Feb, 2022 | 08:23h | UTC

Efficacy and safety of risankizumab for active psoriatic arthritis: 24-week results from the randomised, double-blind, phase 3 KEEPsAKE 1 trial – Annals of Rheumatic Diseases

 

Short Review | Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2.

2 Feb, 2022 | 08:13h | UTC

Hypersensitivity reactions to vaccines in children: from measles to SARS-CoV-2 – Pediatric Allergy and Immunology

Commentary: Vaccine hypersensitivity in children – News Medical

 

M-A: Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis.

2 Feb, 2022 | 08:20h | UTC

Efficacy and safety of biologics and small molecule drugs for patients with moderate-to-severe ulcerative colitis: a systematic review and network meta-analysis – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

Commentary: Review finds upadacitinib most effective for moderate to severe ulcerative colitis remission – ACP Gastroenterology

 

Observational study suggests Ceftaroline has comparable efficacy vs. Daptomycin for the treatment of Methicillin-Resistant Staphylococcus aureus bloodstream infection.

2 Feb, 2022 | 08:07h | UTC

Multicenter Cohort Study of Ceftaroline versus Daptomycin for Treatment of Methicillin-Resistant Staphylococcus aureus Bloodstream Infection – Open Forum Infectious Diseases

 

Commentary on Twitter

 

Observational study: Pharmacist involvement in the care of critically ill patients may reduce resource utilization, adverse drug events, and medical costs.

1 Feb, 2022 | 09:47h | UTC

PHarmacist Avoidance or Reductions in Medical Costs in CRITically Ill Adults: PHARM-CRIT Study – Critical Care Explorations

 

Commentary from the author on Twitter (thread – click for more)

 

Does the world need an Omicron vaccine? What researchers say.

1 Feb, 2022 | 08:53h | UTC

Does the world need an Omicron vaccine? What researchers say – Nature

 

M-A: Vasopressin and glucocorticoids for in-hospital cardiac arrest.

1 Feb, 2022 | 08:43h | UTC

Vasopressin and glucocorticoids for in-hospital cardiac arrest: A systematic review and meta-analysis of individual participant data – Resuscitation

Related: RCT: Vasopressin + Methylprednisolone increase the likelihood of return of spontaneous circulation compared to placebo in patients with in-hospital cardiac arrest.

 

Commentary on Twitter

 

The extraordinary success of Covid-19 vaccines, in two charts.

1 Feb, 2022 | 08:48h | UTC

The extraordinary success of Covid-19 vaccines, in two charts – Vox

 

RCT: In patients with rheumatoid arthritis, treatment with oral drug Tofacitinib increases cardiovascular and cancer risk compared to treatment with subcutaneous TNF inhibitors.

1 Feb, 2022 | 08:35h | UTC

Cardiovascular and Cancer Risk with Tofacitinib in Rheumatoid Arthritis – New England Journal of Medicine (link to abstract – $ for full-text)

Video: CV and Cancer Risk with Tofacitinib in RA – New England Journal of Medicine

Commentary: CV, Cancer Risk Up With Tofacitinib for Rheumatoid Arthritis – HealthDay

 

RCT: Sugemalimab improves progression-free survival vs. placebo in patients with metastatic non-small-cell lung cancer.

1 Feb, 2022 | 08:25h | UTC

Sugemalimab versus placebo, in combination with platinum-based chemotherapy, as first-line treatment of metastatic non-small-cell lung cancer (GEMSTONE-302): interim and final analyses of a double-blind, randomised, phase 3 clinical trial – The Lancet Oncology (link to abstract – $ for full-text)

Related study: Sugemalimab versus placebo after concurrent or sequential chemoradiotherapy in patients with locally advanced, unresectable, stage III non-small-cell lung cancer in China (GEMSTONE-301): interim results of a randomised, double-blind, multicentre, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentaries:

Sugemalimab shows promise for locally advanced, metastatic NSCLC – Medicine Matters

Sugemalimab Boosts Outcomes in NSCLC – MedPage Today (free registration required)

 

Commentary on Twitter

 

Meta-analysis: Androgen deprivation therapy, in addition to radiotherapy, is associated with improved metastasis-free survival in men with localized prostate cancer.

1 Feb, 2022 | 08:24h | UTC

Androgen deprivation therapy use and duration with definitive radiotherapy for localised prostate cancer: an individual patient data meta-analysis – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: Effect of ADT Use and Duration in Combination With Definitive Radiotherapy for Localized Prostate Cancer – The ASCO Post

 

Registry study in Denmark found an increased bleeding risk with the association of systemic Fluconazole and Apixaban (OR 3.5; 95% CI, 1.4-10.6).

1 Feb, 2022 | 08:13h | UTC

Bleeding Risk Following Systemic Fluconazole or Topical Azoles in Patients with Atrial Fibrillation on Apixaban, Rivaroxaban, or Dabigatran – American Journal of Medicine

 

Observational analysis in Lombardy, Italy, showed a gradual decrease in protection against SARS-CoV-2 clinical outcomes after the second dose of vaccine.

30 Jan, 2022 | 14:51h | UTC

Persistence of protection against SARS-CoV-2 clinical outcomes up to 9 months since vaccine completion: a retrospective observational analysis in Lombardy, Italy – The Lancet Infectious Diseases

Commentary: COVID-19 vaccine: what are we doing and what should we do? – The Lancet Infectious Diseases

 

FDA halts use of antibody drugs that don’t work vs. Omicron.

30 Jan, 2022 | 14:35h | UTC

FDA halts use of antibody drugs that don’t work vs. omicron – Associated Press

Related: Lab study shows new antiviral pills maintain efficacy against Omicron, but antibody drugs are substantially less effective.

 

RCT: Vitamin D supplementation for older adults (mean age 67 years) for 5 years reduced the risk of autoimmune diseases by 22%. Absolute risk in the treatment group was 0.95% vs. 1.19% in the placebo group.

30 Jan, 2022 | 14:30h | UTC

Vitamin D and marine omega 3 fatty acid supplementation and incident autoimmune disease: VITAL randomized controlled trial – The BMJ

Commentary: Vitamin D and fish oil supplements may help prevent autoimmune disease, study says – CNN

Related:

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

RCT: Vitamin D supplementation is not beneficial for the prevention of cardiovascular disease and cancer.

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

USPSTF Statement: Insufficient evidence to recommend Vitamin D deficiency screening

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

 

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

30 Jan, 2022 | 14:34h | UTC

Myocarditis after BNT162b2 Vaccination in Israeli Adolescents – New England Journal of Medicine

Related:

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Commentary on Twitter

 

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