Pharmacology

Chloroquine and hydroxychloroquine in covid-19 – Tue BMJ

“Use of these drugs is premature and potentially harmful.”

 


FDA Approves Label Changes to SGLT2 Inhibitors Regarding Temporary Discontinuation of Medication Before Scheduled Surgery – U.S. Food & Drug Administration (free)

Commentary: FDA advises stopping SGLT2 inhibitor treatment prior to surgery – The Hospitalist (free)

“- Canagliflozin, dapagliflozin, and empagliflozin should each be discontinued at least three days before scheduled surgery.

Ertugliflozin should be discontinued at least four days before scheduled surgery.

– Blood glucose levels should be carefully monitored after discontinuation of the SGLT2 inhibitor and appropriately managed before surgery.”

 


Association Between Renin-Angiotensin System Blockade Discontinuation and All-Cause Mortality Among Persons With Low Estimated Glomerular Filtration Rate – JAMA Internal Medicine (free for a limited period)

Editorial: Continuation of Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in the Face of Kidney Disease Progression—Safe and Possibly Life Saving (free for a limited period)

 

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Model List of Essential Medicines – World Health Organization (free)

News Release: WHO launches a digital version of its Model list of Essential Medicines (EML) – World Health Organization (free)

Related: WHO Updates Global Guidance on Medicines and Diagnostic Tests (free resources)

 

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Evaluation of a Common Prescribing Cascade of Calcium Channel Blockers and Diuretics in Older Adults With Hypertension – JAMA Internal Medicine (free for a limited period)

Commentary: Antihypertensive Prescribing Cascades as High-Priority Targets for Deprescribing – JAMA Internal Medicine (free for a limited period)

 

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Daily emollient during infancy for prevention of eczema: the BEEP randomised controlled trial – The Lancet (free)

Related Study: Skin emollient and early complementary feeding to prevent infant atopic dermatitis (PreventADALL): a factorial, multicentre, cluster-randomised trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Emollients for prevention of atopic dermatitis in infancy – The Lancet (free) AND Daily moisturizer does not prevent eczema according to new research – News Medical (free)

 

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Leg ulcer infection: antimicrobial prescribing – National Institute for Health and Care Excellence (free)

Related: NICE Antimicrobial prescribing guidelines (resource covering many common conditions) AND NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)

 

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Drugs for Some Common Eye Disorders – JAMA (free for a limited period)

If the link above does not work, try this one

 

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Recommended Adult Immunization Schedule, United States, 2020 – Annals of Internal Medicine (free)

Commentary: ACIP releases updated vaccination schedule with several changes – ACP Hospitalist (free)

 

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Eliminating Medication Overload: A National Action Plan – Lown Institute (free PDF)

Press Release: Millions of Older Americans Harmed by Too Many Medications – Lown Institute (free)

Commentary: ‘Small’ tactics to counter Big Pharma’s influence on medication overload – STAT (free)

Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

 

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Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2019 – Centers for disease Control and Prevention (free)

Commentaries: CDC: Tdap Acceptable Alternative to Td Vaccine – NEJM Journal Watch (free) AND ACIP: Updated Recommendations for Tdap Vaccination – MPR (free)

 

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Vaccination of Infants with Meningococcal Group B Vaccine (4CMenB) in England – New England Journal of Medicine (link to abstract – $ for full-text)

Related Study: Meningococcal B Vaccine and Meningococcal Carriage in Adolescents in Australia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Vaccine prevents deadly meningitis B in infants – Reuters (free)

 

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Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: #VisualAbstract: Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X) – 2 Minute Medicine (free)

 

 


Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial – JAMA Psychiatry (free)

Editorial: The Potential Role of Lumateperone—Something Borrowed? Something New? – JAMA Psychiatry (free for a limited period)

 

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FDA and NIH let clinical trial sponsors keep results secret and break the law – Science (a few articles per month are free)

 

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Adverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials – The Lancet Infectious Diseases (free registration required)

Commentaries: What is the best regimen to treat latent tuberculosis infection? – The Lancet Infectious Diseases (free) AND Four Months of Rifampicin May Be Best Option for Latent TB – Medscape / Reuters (free registration required)

 

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Olanzapine 5 mg plus standard antiemetic therapy for the prevention of chemotherapy-induced nausea and vomiting (J-FORCE): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

 

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Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

 

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Guideline Homepage: ADA 2020 Standards of Medical Care in Diabetes – American Diabetes Association (free supplement)

Commentaries: ADA 2020 Standards of Care Incorporate CVD Risk Stratification, New Medications – Endocrinology Advisor (free) AND ADA releases 2020 standards of medical care in diabetes – University of North Carolina at Chapel Hill School of Medicine (free)

See also: Standards of Medical Care in Diabetes—2020 Abridged for Primary Care Providers – American Diabetes Association (free PDF) AND 2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) – Diabetologia (free)

 

See ADA 2020 Guideline topics below:

Introduction: Standards of Medical Care in Diabetes—2020

Summary of Revisions: Standards of Medical Care in Diabetes—2020

  1. Improving Care and Promoting Health in Populations: Standards of Medical Care in Diabetes2020
  2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2020
  3. Prevention or Delay of Type 2 Diabetes: Standards of Medical Care in Diabetes—2020
  4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes—2020
  5. Facilitating Behavior Change and Well-being to Improve Health Outcomes: Standards of Medical Care in Diabetes—2020
  6. Glycemic Targets: Standards of Medical Care in Diabetes—2020
  7. Diabetes Technology: Standards of Medical Care in Diabetes—2020
  8. Obesity Management for the Treatment of Type 2 Diabetes: Standards of Medical Care in Diabetes—2020
  9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2020
  10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2020
  11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes−2020
  12. Older Adults: Standards of Medical Care in Diabetes—2020
  13. Children and Adolescents: Standards of Medical Care in Diabetes−2020
  14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes—2020
  15. Diabetes Care in the Hospital: Standards of Medical Care in Diabetes—2020

 

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Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Newer Drug Falls Short for Quick Prehospital Intubation – MedPage Today (free registration required)

 

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