Pharmacology

Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial – The Lancet (free)

Invited Commentary: Angiotensin-II receptor blockade in Marfan syndrome – The Lancet (free)

 

Related Commentary on Twitter

 


Pathways to independence: towards producing and using trustworthy evidence – The BMJ (free)

See Complete Series: Commercial Influence in Health: from Transparency to Independence (free articles)

Commentary: Time to end drug company distortion of medical evidence – The Conversation (free)

 

Related Commentary on Twitter

 


Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Head-to-head comparison finds three anti-seizure drugs equally effective for severe form of epilepsy – NIH News Release (free)

 

Related Commentary on Twitter

 


Toward Increased Understanding of the Steroid Controversy in Septic Shock – Critical Care Medicine (free)

See also: Why Understanding Sepsis Endotypes Is Important for Steroid Trials in Septic Shock (free) AND Why the Adjunctive Corticosteroid Treatment in Critically Ill Patients With Septic Shock (ADRENAL) Trial Did Not Show a Difference in Mortality (free) AND Why My Steroid Trials in Septic Shock Were “Positive” (free)

Related: Review: Adjunctive Corticosteroid Treatment in Septic Shock (free review, guideline, and meta-analysis on the subject)

 

Related Commentary on Twitter

 


A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Treat Stroke to Target Finds Lower Risk of CV Events With Lower LDL-C Levels – American College of Cardiology (free) AND Treat Stroke to Target – Treat Stroke to Target – American College of Cardiology (free) AND Lower Cholesterol Cuts CV Events: Treat Stroke to Target Trial – TCTMD (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

Related Commentary on Twitter

 


Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism – JAMA Internal Medicine (free for a limited period)

 

Related Commentary on Twitter

 


Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials – JAMA (free for a limited period)

Commentary: Supplements don’t preserve kidney health in Type 2 diabetes – University of Washington School of Medicine (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

Related Commentary on Twitter

 


A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Novel Drug Eases Uremic Pruritus – Renal & Urology News (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 


UPDATE: The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication – U.S Food and Drug Administration (free)

Commentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)

“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”

 


Randomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)

Source: EvidenceAlerts

“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”

 


Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients – Nature Medicine (link to abstract – $ for full-text)

Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)

 

Related Commentary on Twitter

 


Association between gifts from pharmaceutical companies to French general practitioners and their drug prescribing patterns in 2016: retrospective study using the French Transparency in Healthcare and National Health Data System databases – The BMJ (free)

 

Related Commentary on Twitter

 


Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care – Annals of Rheumatic Diseases (free)

 

Related Commentary on Twitter

 


Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele – New England Journal of Medicine (link to abstract – $ for full-text)

Editorial: Realizing the Dream of Molecularly Targeted Therapies for Cystic Fibrosis (free)

Related Research: Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Three-drug combo improves lung function in most common genetic form of cystic fibrosis – UT Southwestern Medical Center (free)

 

Related Commentary on Twitter


Real-Time Benefit Tools for Drug Prices – JAMA (free for a limited period)

 


Trends in Internet Searches for Cannabidiol (CBD) in the United States – JAMA Network Open (free)

Commentaries: Interest in CBD products keeps soaring, but health experts wary – HealthDay (free) AND Online Searches For CBD Skyrocket – MedicalResearch.com (free)

 

Related Commentary on Twitter

 


Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study – The BMJ (free)

 

Related Commentary on Twitter

 


Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Lefamulin—A New Antibiotic for Community-Acquired Pneumonia (free for a limited period)

 

Related Commentary on Twitter

 


Should antidepressants be used for major depressive disorder? – BMJ Evidence-Based Medicine (free)

Related Meta-analysis: Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis – The Lancet (free)

Related Commentary: Do Antidepressants Work? – The New York Times (10 articles per month are free)

“Generally, all the previous reviews show that antidepressants seem to have statistically significant effects on depressive symptoms, but the size of the effect has questionable importance to most patients.”

 


Commentaries: Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction – DAPA-HF – American College of Cardiology (free) Dapagliflozin reduces death and hospitalisation in patients with heart failure – European Society of Cardiology (free)

 

Related Commentary on Twitter

 


Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical Trial – JAMA (free for a limited period)

Commentary: High-Dose Vitamin D Might Reduce Bone Mineral Density – NEJM Journal Watch (free)

 

Related Commentary on Twitter

 


Identifying optimal doses of heart failure medications in men compared with women: a prospective, observational, cohort study – The Lancet (link to abstract – $ for full-text)

 

Related Commentary on Twitter

 


Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ (free)

Related: Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention (link to abstract and commentary) AND NICE Guideline: Vitamin D Supplementation (free)

Vitamin D supplementation was not associated with all-cause mortality, cardiovascular mortality, or non-cancer, non-cardiovascular mortality. However, Vitamin D supplementation statistically significantly reduced the risk of cancer death by 16%.

 

Related Commentary on Twitter

 


Medications Affecting the Biochemical Conversion to Type 2 Diabetes: A Systematic Review and Meta-Analysis – The Journal of Clinical Endocrinology & Metabolism (free)

α-Glucosidase inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, metformin, orlistat, phentermine/topiramate, and pioglitazone significantly reduced the risk of biochemical conversion to T2DM, whereas statins and nateglinide increased the risk”

 


Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant – JAMA Internal Medicine (free for a limited period)

Commentary: Study Sheds Light on Stopping and Resuming DOACs in Afib Patients Undergoing Surgery – NEJM Journal Watch (free)

“The DOAC regimens were omitted for 1 day before a low–bleeding-risk procedure and 2 days before a high–bleeding-risk procedure. The DOAC regimens were resumed 1 day after a low–bleeding-risk procedure and 2 to 3 days after a high–bleeding-risk procedure.”

 

Related Commentary on Twitter

 


Potential Medicare Savings From Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers – JAMA Internal Medicine (free for a limited period)

“By maximizing generic substitution and therapeutic interchange, Medicare could have saved approximately $676 million (89.6%) in 2016 and 2017 of the total $754 million spent on these brand-name ACEIs and ARBs during those 2 years”.

 


Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial – The Lancet (free)

Commentary: Oral regimen management of acute hypertension in pregnancy – The Lancet (free)

 

Related Commentary on Twitter