Pharmacology

Leg ulcer infection: antimicrobial prescribing – National Institute for Health and Care Excellence (free)

Related: NICE Antimicrobial prescribing guidelines (resource covering many common conditions) AND NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)

 

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Drugs for Some Common Eye Disorders – JAMA (free for a limited period)

If the link above does not work, try this one

 

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Recommended Adult Immunization Schedule, United States, 2020 – Annals of Internal Medicine (free)

Commentary: ACIP releases updated vaccination schedule with several changes – ACP Hospitalist (free)

 

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Eliminating Medication Overload: A National Action Plan – Lown Institute (free PDF)

Press Release: Millions of Older Americans Harmed by Too Many Medications – Lown Institute (free)

Commentary: ‘Small’ tactics to counter Big Pharma’s influence on medication overload – STAT (free)

Related: Reducing Inappropriate Medication Use & Polypharmacy (several articles and commentaries on the subject)

 

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Use of Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccines: Updated Recommendations of the Advisory Committee on Immunization Practices — United States, 2019 – Centers for disease Control and Prevention (free)

Commentaries: CDC: Tdap Acceptable Alternative to Td Vaccine – NEJM Journal Watch (free) AND ACIP: Updated Recommendations for Tdap Vaccination – MPR (free)

 

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Vaccination of Infants with Meningococcal Group B Vaccine (4CMenB) in England – New England Journal of Medicine (link to abstract – $ for full-text)

Related Study: Meningococcal B Vaccine and Meningococcal Carriage in Adolescents in Australia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Vaccine prevents deadly meningitis B in infants – Reuters (free)

 

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Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X): a randomised, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: #VisualAbstract: Ixekizumab for patients with non-radiographic axial spondyloarthritis (COAST-X) – 2 Minute Medicine (free)

 

 


Efficacy and Safety of Lumateperone for Treatment of Schizophrenia: A Randomized Clinical Trial – JAMA Psychiatry (free)

Editorial: The Potential Role of Lumateperone—Something Borrowed? Something New? – JAMA Psychiatry (free for a limited period)

 

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FDA and NIH let clinical trial sponsors keep results secret and break the law – Science (a few articles per month are free)

 

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Adverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials – The Lancet Infectious Diseases (free registration required)

Commentaries: What is the best regimen to treat latent tuberculosis infection? – The Lancet Infectious Diseases (free) AND Four Months of Rifampicin May Be Best Option for Latent TB – Medscape / Reuters (free registration required)

 

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Olanzapine 5 mg plus standard antiemetic therapy for the prevention of chemotherapy-induced nausea and vomiting (J-FORCE): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

 

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Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

 

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Guideline Homepage: ADA 2020 Standards of Medical Care in Diabetes – American Diabetes Association (free supplement)

Commentaries: ADA 2020 Standards of Care Incorporate CVD Risk Stratification, New Medications – Endocrinology Advisor (free) AND ADA releases 2020 standards of medical care in diabetes – University of North Carolina at Chapel Hill School of Medicine (free)

See also: Standards of Medical Care in Diabetes—2020 Abridged for Primary Care Providers – American Diabetes Association (free PDF) AND 2019 update to: Management of hyperglycaemia in type 2 diabetes, 2018. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD) – Diabetologia (free)

 

See ADA 2020 Guideline topics below:

Introduction: Standards of Medical Care in Diabetes—2020

Summary of Revisions: Standards of Medical Care in Diabetes—2020

  1. Improving Care and Promoting Health in Populations: Standards of Medical Care in Diabetes2020
  2. Classification and Diagnosis of Diabetes: Standards of Medical Care in Diabetes—2020
  3. Prevention or Delay of Type 2 Diabetes: Standards of Medical Care in Diabetes—2020
  4. Comprehensive Medical Evaluation and Assessment of Comorbidities: Standards of Medical Care in Diabetes—2020
  5. Facilitating Behavior Change and Well-being to Improve Health Outcomes: Standards of Medical Care in Diabetes—2020
  6. Glycemic Targets: Standards of Medical Care in Diabetes—2020
  7. Diabetes Technology: Standards of Medical Care in Diabetes—2020
  8. Obesity Management for the Treatment of Type 2 Diabetes: Standards of Medical Care in Diabetes—2020
  9. Pharmacologic Approaches to Glycemic Treatment: Standards of Medical Care in Diabetes—2020
  10. Cardiovascular Disease and Risk Management: Standards of Medical Care in Diabetes—2020
  11. Microvascular Complications and Foot Care: Standards of Medical Care in Diabetes−2020
  12. Older Adults: Standards of Medical Care in Diabetes—2020
  13. Children and Adolescents: Standards of Medical Care in Diabetes−2020
  14. Management of Diabetes in Pregnancy: Standards of Medical Care in Diabetes—2020
  15. Diabetes Care in the Hospital: Standards of Medical Care in Diabetes—2020

 

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Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Newer Drug Falls Short for Quick Prehospital Intubation – MedPage Today (free registration required)

 

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Irbesartan in Marfan syndrome (AIMS): a double-blind, placebo-controlled randomised trial – The Lancet (free)

Invited Commentary: Angiotensin-II receptor blockade in Marfan syndrome – The Lancet (free)

 

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Pathways to independence: towards producing and using trustworthy evidence – The BMJ (free)

See Complete Series: Commercial Influence in Health: from Transparency to Independence (free articles)

Commentary: Time to end drug company distortion of medical evidence – The Conversation (free)

 

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Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Head-to-head comparison finds three anti-seizure drugs equally effective for severe form of epilepsy – NIH News Release (free)

 

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Toward Increased Understanding of the Steroid Controversy in Septic Shock – Critical Care Medicine (free)

See also: Why Understanding Sepsis Endotypes Is Important for Steroid Trials in Septic Shock (free) AND Why the Adjunctive Corticosteroid Treatment in Critically Ill Patients With Septic Shock (ADRENAL) Trial Did Not Show a Difference in Mortality (free) AND Why My Steroid Trials in Septic Shock Were “Positive” (free)

Related: Review: Adjunctive Corticosteroid Treatment in Septic Shock (free review, guideline, and meta-analysis on the subject)

 

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A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Treat Stroke to Target Finds Lower Risk of CV Events With Lower LDL-C Levels – American College of Cardiology (free) AND Treat Stroke to Target – Treat Stroke to Target – American College of Cardiology (free) AND Lower Cholesterol Cuts CV Events: Treat Stroke to Target Trial – TCTMD (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism – JAMA Internal Medicine (free for a limited period)

 

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Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials – JAMA (free for a limited period)

Commentary: Supplements don’t preserve kidney health in Type 2 diabetes – University of Washington School of Medicine (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

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A Phase 3 Trial of Difelikefalin in Hemodialysis Patients with Pruritus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Novel Drug Eases Uremic Pruritus – Renal & Urology News (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 


UPDATE: The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication – U.S Food and Drug Administration (free)

Commentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)

“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”

 


Randomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)

Source: EvidenceAlerts

“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”

 


Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients – Nature Medicine (link to abstract – $ for full-text)

Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)

 

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Association between gifts from pharmaceutical companies to French general practitioners and their drug prescribing patterns in 2016: retrospective study using the French Transparency in Healthcare and National Health Data System databases – The BMJ (free)

 

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Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care – Annals of Rheumatic Diseases (free)

 

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Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele – New England Journal of Medicine (link to abstract – $ for full-text)

Editorial: Realizing the Dream of Molecularly Targeted Therapies for Cystic Fibrosis (free)

Related Research: Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Three-drug combo improves lung function in most common genetic form of cystic fibrosis – UT Southwestern Medical Center (free)

 

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Real-Time Benefit Tools for Drug Prices – JAMA (free for a limited period)

 


Trends in Internet Searches for Cannabidiol (CBD) in the United States – JAMA Network Open (free)

Commentaries: Interest in CBD products keeps soaring, but health experts wary – HealthDay (free) AND Online Searches For CBD Skyrocket – MedicalResearch.com (free)

 

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