Guideline: Safe Medication Use in the ICU

21Aug
2017

Meta-analysis: Acute Kidney Injury After Computed Tomography

21Aug
2017

Acute Kidney Injury After Computed Tomography: A Meta-analysis – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary: When kidneys are injured, CT contrast isn’t the culprit – Health Imaging (free)

Related article: Risk of Acute Kidney Injury After Intravenous Contrast Media Administration – Annals of Emergency Medicine (free)

Source: Hospital Medicine Virtual Journal Club

Compared with noncontrast CT, contrast-enhanced CT was not significantly associated with either acute kidney injury, need for renal replacement therapy, or all-cause mortality.

 

Study: probiotics can prevent sepsis in newborns

17Aug
2017

Too Many Drug Trials, Too Few Patients

17Aug
2017

Cardiac Toxicity Of Cancer Chemotherapy

17Aug
2017

New 8-Week Treatment Approved for All Hepatitis C Genotypes

17Aug
2017

New 8-Week Treatment Approved for All Hepatitis C Genotypes – Physician’s First Watch (free)

See also: FDA News Release

Standard treatment length was previously 12 weeks or more.

 

Benefits and safety of gabapentinoids in chronic low back pain

16Aug
2017

An Automated, Pharmacist-Driven Initiative Improves Quality of Care for Staphylococcus aureus Bacteremia

16Aug
2017

Pioglitazone may increase bladder cancer risk

16Aug
2017

Special issue: 60 years of metformin use

16Aug
2017

SGLT2 agents may reduce cardiovascular risk in diabetics

16Aug
2017

The Effects of Cannabis Among Adults With Chronic Pain

15Aug
2017

Risk traumatic brain injuries associated with antidepressant use among patients with Alzheimer’s disease

15Aug
2017

Pharma Phantasy: The $30 Billion PCSK9 Inhibitor Market

15Aug
2017

Ibuprofen versus placebo effect on acute kidney injury in ultramarathons

15Aug
2017

Mechanisms of action and rationale for the use of checkpoint inhibitors in cancer

15Aug
2017

Car crashes in older adult drivers using Zolpidem

15Aug
2017

Effect of 0.5 mg versus 1 mg varenicline for smoking cessation

14Aug
2017

Effect of 0.5 mg versus 1 mg varenicline for smoking cessation: a randomized controlled trial – Addiction (link to abstract – $ for full-text)

“No difference in smoking cessation effectiveness between 1 mg and 0.5 mg twice daily varenicline” (46.5% vs 46.4%) (RT @JorgeMTamayo see Tweet)

 

Risk of Stroke With Various Types of Menopausal Hormone Therapies

14Aug
2017

Risk of Stroke With Various Types of Menopausal Hormone Therapies: A National Cohort Study – Stroke (link to abstract – $ for full-text)

Source: EvidenceAlerts

This large cohort confirms an increased stroke risk with oral hormone therapies, but suggests no increased risk of stroke with transdermal or vaginal estrogen application.

 

Once-Daily, Single-Tablet Regimen Suppressed HIV

14Aug
2017

Exenatide for Parkinson’s disease?

11Aug
2017

Lithium Associated With a Higher Risk of Chronic Kidney Disease in Older Adults

11Aug
2017

Lithium Use, but Not Valproate Use, Is Associated With a Higher Risk of Chronic Kidney Disease in Older Adults With Mental Illness – The Journal of Clinical Psychiatry (link to abstract -$ for full-text)

Case-control study suggests Lithium is associated with increased risk of chronic kidney disease.

 

Counseling Adolescents About Contraception

11Aug
2017

Present and future of metastatic colorectal cancer treatment

11Aug
2017

Interventions for emergency contraception

10Aug
2017

On-demand pre-exposure prophylaxis for HIV

10Aug
2017

Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study – The Lancet HIV (free registration required)

Commentaries: PrEP on demand or every day? – The Lancet HIV (free registration required) AND HIV pre-exposure prophylaxis can be taken as needed – Reuters (free)

“four doses of PrEP around the time of sexual activity cut the risk of HIV by 97 percent” (from Reuters Health)

 

Antipsychotic drugs for the acute treatment of patients with a first episode of schizophrenia

10Aug
2017

What do hypnotics cost hospitals and healthcare?

10Aug
2017

What do hypnotics cost hospitals and healthcare? – F1000 Research (free)

Source: Hospital Medicine Virtual Journal Club

“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.

 

How long should I take antibiotics?

9Aug
2017

Treatment for Hepatitis C Virus by Community-Based Nonspecialist Providers

9Aug
2017

Gadolinium deposition in the brain: summary of evidence and recommendations

9Aug
2017

Too Many Meds?

5Aug
2017

Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free)

See more on “Deprescribing” in our May 8th issue (see #7), May 9th issue (see #4) and May 15th issue (see #2), and also a related article on Current and future perspectives on the management of polypharmacy

“Yes. Way Too Many Meds. Think De-prescribe”. (RT @EricTopol see Tweet)

 

Bevacizumab for advanced cervical cancer

3Aug
2017

Bevacizumab for advanced cervical cancer: final overall survival and adverse event analysis of a randomised, controlled, open-label, phase 3 trial – The Lancet (link to abstract – $ for full-text)

“Benefit of adding bevacizumab to CT for cervical cancer is sustained: OS curves remain separated with ext. follow-up” and “Unfortunately though bevacizumab is out of reach of many patients living in #LMICs” (RT @oncology_bg see Tweets)

 

Trial of Tocilizumab in Giant-Cell Arteritis

3Aug
2017

Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome

3Aug
2017

Opioid Use in Pregnancy, Neonatal Abstinence Syndrome, and Childhood Outcomes

3Aug
2017

Medication errors in anesthesia: unacceptable or unavoidable?

3Aug
2017

Better drugs, faster: The potential of AI-powered humans

1Aug
2017

Tenofovir reduces mother-to-child hepatitis B transmission

1Aug
2017

Association of Statin Use With Risk of Back Disorder Diagnoses

27Jul
2017

Antipsychotics in Acute Schizophrenia

27Jul
2017

Sixty Years of Placebo-Controlled Antipsychotic Drug Trials in Acute Schizophrenia: Systematic Review, Bayesian Meta-Analysis, and Meta-Regression of Efficacy Predictors – American Journal of Psychiatry (link to abstract – $ for full-text)

Commentary: Antipsychotic Response Rates Through the Prism of 60 Years – Psychiatric Times (free)

Source: EvidenceAlerts (free resource to find articles of interest)

Twice as many patients improved with antipsychotics as with placebo, confirming the benefits of antipsychotic drugs for the treatment of schizophrenia.

 

 

Ivermectin – Old Drug, New Tricks?

27Jul
2017

Recent advances in the treatment of venous thromboembolism in the era of the direct oral anticoagulants

25Jul
2017

Inconsistent Guideline Recommendations for Cardiovascular Prevention

25Jul
2017

Viewpoint: Treatment of Cholesterol in 2017

25Jul
2017

High-dose versus standard-dose influenza vaccination on hospitalizations

25Jul
2017

Is cyclobenzaprine useful for pain?

25Jul
2017

Is cyclobenzaprine useful for pain? – Therapeutics Initiative (free)

“…cyclobenzaprine is a long-acting sedative, not a muscle relaxant, and questioning whether any potential benefits are worth the side effects”. (from TI Newsletter). “If prescribed, a dose of 5 mg at bedtime should be tried first.  Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week”.

 

New Long-Acting Injectable HIV Therapies

25Jul
2017

NHS to end prescription of homeopathic remedies

24Jul
2017

The Myth of Drug Expiration Dates

23Jul
2017

The Myth of Drug Expiration Dates – ProPublica (free)

“Hospitals and pharmacies are required to toss expired drugs, no matter how expensive or vital. Meanwhile the FDA has long known that many remain safe and potent for years longer”.

 

Surrogate endpoints in oncology: when are they acceptable for regulatory and clinical decisions, and are they currently overused?

23Jul
2017

Prophylactic Early Erythropoietin for Neuroprotection in Preterm Infants

23Jul
2017

Report: Pain Management and the Opioid Epidemic: Balancing Societal and Individual Benefits and Risks of Prescription Opioid Use

23Jul
2017

Emicizumab Prophylaxis in Hemophilia A with Inhibitors

23Jul
2017

Reviews on thrombosis and hemostasis

23Jul
2017

Studies Compare Types of Insulin for Reducing Episodes of Low Blood Sugar for Patients with Type 1 or 2 Diabetes

22Jul
2017

Effectiveness of Pharmacist Intervention to Reduce Medication Errors and Health-Care Resources Utilization After Transitions of Care

22Jul
2017

Effectiveness of Pharmacist Intervention to Reduce Medication Errors and Health-Care Resources Utilization After Transitions of Care: A Meta-analysis of Randomized Controlled Trials – Journal of Patient Safety (link to abstract – $ for full-text)

Source: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)

Pharmacist transition of care intervention seems to be an effective strategy to reduce medication errors after hospital discharge and to reduce subsequent emergency room visits.

 

Poor-Quality Medicine: A Global Pandemic

22Jul
2017

Poor-Quality Medicine: A Global Pandemic – Devex (free)

“Each year, the proliferation of substandard and falsified medicines puts the lives of millions of people – particularly those living in developing countries – at risk”

 

Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin

21Jul
2017

Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Adjusting Antiplatelet Regimen Could Decrease Risk For Stroke Patients on Aspirin Monotherapy – American College of Cardiology, Latest in Cardiology (free)

Meta-analysis of cohort studies: in patients who experienced an ischemic stroke or transient ischemic attack while on aspirin monotherapy, the addition of or a switch to another antiplatelet agent, versus aspirin monotherapy, was associated with a 32 percent reduction in the risk of major adverse cardiovascular events (HR 0.68; 0.54–0.85) and 30 percent reduction in recurrent strokes (HR, 0.70; 0.54–0.92). Additional randomized trials would better clarify the best antiplatet regimen for these patients.

 

Antidepressants during pregnancy and autism in offspring

21Jul
2017

American Society of Clinical Oncology Position Statement On Addressing the Affordability of Cancer Drugs

21Jul
2017

Use of antibiotics during pregnancy and the risk of major congenital malformations

21Jul
2017

Use of antibiotics during pregnancy and the risk of major congenital malformations: A population based cohort study – British Journal of Pharmacology (link to abstract – $ for full-text)

Commentary: New study finds link between certain antibiotics during pregnancy and risk for birth defects – News Medical (free)

Related article: Use of antibiotics during pregnancy and risk of spontaneous abortion – Canadian Medical Association Journal (free)

In this large cohort clindamycin, doxycycline, quinolones, macrolides, and phenoxymethylpenicillin were associated with congenital malformations. Amoxicillin, cephalosporins, and nitrofurantoin were not associated with birth defects.

 

Oral antifungal medication for toenail onychomycosis

20Jul
2017

Cochrane What is the best medication for a fungal infection of the toenail? – Cochrane Library (free)

Full review: Oral antifungal medication for toenail onychomycosis – Cochrane Library (link to abstract – $ for full-text)

Terbinafine probably leads to better cure rates than azoles, with the same risk of adverse events. Griseofulvin is no better and has more adverse effects than azoles.

 

New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

20Jul
2017

Patient Outcomes in Dose Reduction or Discontinuation of Long-Term Opioid Therapy

20Jul
2017

ECCO Position Statement on the Use of Biosimilars for Inflammatory Bowel Disease

18Jul
2017

Enabling Precision Medicine: The Role of Genetics in Clinical Drug Development

18Jul
2017

Systematic review: Antiepileptic drug monotherapy

17Jul
2017

The hidden truth about our prescription medications

16Jul
2017

The hidden truth about our prescription medications – Ideas.Ted.Com (free)

“Uncovering the tale of hidden clinical trial data on prescription drugs” (RT @CebmOxford see Tweet) AND “Around half of the clinical trials that were done on the medicines we use today have never published their results…” (RT @Students4BE see Tweet)

 

Editorial: WHO downgrades status of oseltamivir

16Jul
2017

Editorial: WHO downgrades status of oseltamivir – The BMJ (free)

@WHO downgrades status of oseltamivir. BMJ editorial discusses important lessons from the Tamiflu story” (RT @bmj_latest  see Tweet)

 

NCCN Guidelines Insights: Antiemesis

13Jul
2017

Non-health care facility medication errors resulting in serious medical outcomes

13Jul
2017

Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia

11Jul
2017

Direct oral anticoagulants for treatment of Heparin-induced Thrombocytopenia

9Jul
2017

Direct oral anticoagulants for treatment of HIT: update of Hamilton experience and literature review – Blood (link to abstract – $ for full-text)

Source: Direct Oral Anticoagulants for Heparin-Induced Thrombocytopenia – Journal Watch ($)

This literature review and observational study suggest direct oral anticoagulants (rivaroxaban, apixaban, dabigatran) are safe and effective for the treatment of Heparin-induced Thrombocytopenia.

 

Medication nonadherence may increase health care costs

8Jul
2017

Longitudinal Patterns of Medication Nonadherence and Associated Health Care Costs – Inflammatory Bowel Diseases (link to abstract – $ for full-text)

Commentary: Taking medications as prescribed important to control health care costs – Cincinnati Children’s Hospital Medical Center, via EurekAlert (free)

In this small study, patients with increasing nonadherence over time demonstrate more than a 3-fold increase in costs compared with adherent patients.

 

Lithium Reduces Suicide Risk in Bipolar Patients

7Jul
2017

Rivastigmine reviewed: doubts about dementia drug

7Jul
2017

Rivastigmine reviewed: doubts about dementia drug – Evidently Cochrane (free)

Related review: Rivastigmine for people with Alzheimer’s disease – Cochrane Library (link to abstract – $ for full-text)

“”Sadly, “small” and “of uncertain clinical importance” are the words chosen by the Cochrane reviewers to describe…” (RT @CochraneUK see Tweet)

 

Pharmacologic Management of Type 2 Diabetes Mellitus: Available Therapies

7Jul
2017

Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure

5Jul
2017

Digoxin Use and Subsequent Clinical Outcomes in Patients With Atrial Fibrillation With or Without Heart Failure in the ENGAGE AF‐TIMI 48 Trial – Journal of The American Heart Association (free)

Source: Hospital Medicine Virtual Journal Club

In this observational analysis, patients with atrial fibrillation without heart failure had increased risk of sudden cardiac death with digoxin use. Among patients with heart failure, digoxin use was associated with an increase in all‐cause death, cardiovascular death, sudden cardiac death, and death caused by HF/cardiogenic shock.

 

Risk of death among users of Proton Pump Inhibitors

5Jul
2017

High Generic Drug Prices and Market Competition

4Jul
2017

Common ED Medication Errors: Polypharmacy

4Jul
2017

Potential Drug-Drug and Herb-Drug Interactions in Patients With Cancer

3Jul
2017

Complications of Proton Pump Inhibitor Therapy

30Jun
2017

Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free)

Commentary: Complications of Proton Pump Inhibitor Therapy – PracticeUpdate (free registration required)

Related: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD – Journal of the American Society of Nephrology (link to abstract – registration required for full text) AND Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis – Jama Neurology (link to abstract – subscription required for full text)

The authors of this review argue that the observational studies that brought up the safety issues associated with PPIs (above studies, for example) are insufficient to establish causation and suggest a more balanced approach to PPI prescribing.

 

Judging the benefits and harms of medicines

30Jun
2017

Editorial: Judging the benefits and harms of medicines – The BMJ (free for 15 days)

“Please read/comment on our editorial @bmj_latest about @acmedsci report on judging benefits and harms of medicines” (RT @fgodlee see Tweet)

 

Opinion: Natural health products should be sold separately from drugs

26Jun
2017

Editorial: Natural health products should be sold separately from drugs – Canadian Medical Association Journal (free)

“Separate “natural” products from drugs to protect consumers, says @drstanbrook” (RT @CMAJ see Tweet)

 

Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection

26Jun
2017

Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)

Source: EvidenceAlerts (free resource to find articles of interest)

In this meta-analysis including 19 randomized trials, probiotics given within 2 days of the first antibiotic dose (more effective than if started later) reduced the risk of Clostridium difficile infection (CDI) by >50% in hospitalized adults. 1 case of CDI would be prevented for every 23−144 patients treated with probiotics when antibiotics are started. “There was no convincing evidence of superior efficacy for any of the tested probiotic formulations, delivery methods (drink or capsule), or probiotic doses”.

 

Tamiflu: an expensive lesson in panic stockpiling

26Jun
2017

What happens when an expensive drug is approved based on a lower bar of proof?

25Jun
2017

Insurers Battle Families Over Costly Drug for Fatal Disease – The New York Times (10 articles per month are free)

“A new drug can cost over a million dollars, even though it’s unclear if it works. Now, insurers are refusing to pay” (RT @NYTHealth see Tweet)

 

Update on anti-TNF agents and other new drugs for IBD

23Jun
2017

Performance Improvement: Phenytoin Toxicity

22Jun
2017

Performance Improvement: Phenytoin Toxicity – JAMA (free)

Interesting case of medication error and prevention of subsequent adverse events (RT @JAMA_current see Tweet)

 

The Challenge of Polypharmacy

21Jun
2017

Your vitamin D tests and supplements are probably a waste of money

21Jun
2017

Your vitamin D tests and supplements are probably a waste of money – VOX (free)

Related: Why Are So Many People Popping Vitamin D? – The New York Times (10 articles per month are free)

“Screening for vitamin D has exploded — with no good evidence that it helps people.”

 

The pressure of Big Pharma

21Jun
2017

The pressure of Big Pharma – The Globe and Mail (a few articles per month are free) (RT @CADTH_ACMTS see Tweet)

“Financial conflicts of interest are commonplace in clinical practice guidelines”

 

Evolocumab for Treatment of High Cholesterol: Clinical Effectiveness

19Jun
2017

Hundreds died while taking an arthritis drug, but nobody alerted patients

19Jun
2017

Pain and Opioids in Cancer Care: Benefits, Risks, and Alternatives

16Jun
2017

Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction

15Jun
2017

Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentary: NOAC Doses: Just Stick to the Label – MedPage Today (free registration required)

“Among the 1,473 patients with a renal indication for dose reduction, 43.0% were potentially overdosed, which was associated with a higher risk of major bleeding”

 

Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex for Iron-Deficiency Anemia

15Jun
2017

Effect of Low-Dose Ferrous Sulfate vs Iron Polysaccharide Complex on Hemoglobin Concentration in Young Children With Nutritional Iron-Deficiency Anemia: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

The JAMA Network – For the Media: Treating Nutritional Iron-Deficiency Anemia in Children (free)

Commentaries: Ferrous Sulfate Drops Tied to Higher Hemoglobin Increases in Kids with Anemia – Physician’s First Watch (free) AND Traditional treatment is better for iron-deficiency anaemia in children – OnMedica (free) AND Ferrous Sulfate Effective for Iron-Deficiency Anemia in Kids – Medscape (free registration required)

Researchers expected that Iron Polysaccharide Complex would restore hemoglobin more effectively, because it is designed to be tolerated better, but the proportion of infants and children with a complete resolution of iron-deficiency anemia was higher in the ferrous sulfate group (29 percent vs 6 percent).

 

Real-World Effectiveness of Antipsychotic Treatments

15Jun
2017

Real-World Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of 29 823 Patients With Schizophrenia – JAMA Internal Medicine(link to abstract – $ for full-text)

Commentaries: Oral clozapine, long-acting injectables tied to lower relapse risk in schizophrenia – Clinical Psychiatry News (free registration required) AND Long-Acting Antipsychotics Tied to Superior Outcomes – Medscape (free registration required)

“The risk of rehospitalization is about 20% to 30% lower during long-acting injectable treatments compared with equivalent oral formulations”

 

Page 1 of 212

Share with you friends


Follow Us





Share Button

New! Subscribe to our 10 Stories of the Day.

Interests