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Patient Safety & Quality

SR | Interventions to reduce repetitive ordering of low-value inpatient laboratory tests

27 Mar, 2023 | 13:22h | UTC

Interventions to reduce repetitive ordering of low-value inpatient laboratory tests: a systematic review – BMJ Open Quality

 


Study reveals overuse of surveillance colonoscopy in older adults with limited life expectancy

23 Mar, 2023 | 13:11h | UTC

Summary: This study investigated the association between estimated life expectancy, surveillance colonoscopy findings, and follow-up recommendations among older adults. The study utilized data from the New Hampshire Colonoscopy Registry and included adults over 65 who underwent colonoscopy for surveillance after prior polyps.

Life expectancy was estimated using a validated prediction model and categorized into three groups: less than 5 years, 5 to less than 10 years, and 10 or more years.

Out of the 9,831 adults included in the study, 8% had advanced polyps or CRC. Among the 5,281 patients with available recommendations, 86.9% were advised to return for a future colonoscopy. Surprisingly, 58.1% of older adults with less than 5 years of life expectancy were also recommended to return for future surveillance colonoscopy.

The study concluded that many older adults with limited life expectancy are still recommended for future surveillance colonoscopy. This data could help refine decision-making about pursuing or stopping surveillance colonoscopy in older adults with a history of polyps.

Article: Association of Life Expectancy With Surveillance Colonoscopy Findings and Follow-up Recommendations in Older Adults – JAMA Internal Medicine (link to abstract – $ for full-text)

JAMA Patient Page: What Should I Know About Stopping Routine Cancer Screening?

 

Commentary on Twitter

 


Survey | Perspectives of patients about immediate access to test results through an online patient portal

23 Mar, 2023 | 13:02h | UTC

Summary: This study aimed to assess patient and caregiver attitudes and preferences related to receiving immediately released test results through an online patient portal.

In a survey of 8,139 respondents across 4 US academic medical centers, 95,7% of patients preferred to receive immediately released test results through an online patient portal, even if their healthcare practitioner had not yet reviewed the result. However, 7.5% of respondents reported that reviewing results before being contacted by a healthcare practitioner increased worry. This worry was more common among respondents who received abnormal results (16.5%) compared to those whose results were normal (5%).

The authors concluded that balancing patients’ expectations of immediate access to their information with the need to manage increased worry and healthcare practitioner burden is important as healthcare systems navigate this new era of health information transparency.

Article: Perspectives of Patients About Immediate Access to Test Results Through an Online Patient Portal – JAMA Network Open

News Release: Patients prefer immediate access to medical test results online, even if it’s bad news – UT Southwestern Medical Center

 

Commentary from one of the authors on Twitter

 


Regular measurement is essential but insufficient to improve quality of healthcare

23 Mar, 2023 | 12:33h | UTC

Regular measurement is essential but insufficient to improve quality of healthcare – The BMJ

 


Service delivery redesign is a process, not a model of care

23 Mar, 2023 | 12:32h | UTC

Service delivery redesign is a process, not a model of care – The BMJ

 


Analysis | Networks of care to strengthen primary healthcare in resource constrained settings

21 Mar, 2023 | 13:08h | UTC

Networks of care to strengthen primary healthcare in resource constrained settings – The BMJ

 


White Paper | Best practices in the communication and management of actionable incidental findings in ED imaging

20 Mar, 2023 | 13:34h | UTC

White Paper: Best Practices in the Communication and Management of Actionable Incidental Findings in Emergency Department Imaging – Journal of the American College of Radiology

Commentary: Seven Takeaways from Best Practice Recommendations for Incidental Radiology Findings in the ER – Diagnostic Imaging

 


Critical care outreach teams: a service without walls

20 Mar, 2023 | 13:27h | UTC

Critical care outreach teams: a service without walls – Intensive Care Medicine

 

Commentary on Twitter

 


Review | Evidence-based informed consent form for total knee arthroplasty

17 Mar, 2023 | 12:58h | UTC

Evidence-based informed consent form for total knee arthroplasty – Journal of Orthopaedic Surgery and Research

 


Advantages and challenges of using telehealth for home-based palliative care | Systematic mixed studies review

16 Mar, 2023 | 13:14h | UTC

Advantages and Challenges of Using Telehealth for Home-Based Palliative Care: Systematic Mixed Studies Review – Journal of Medical Internet Research

 


M-A | Low-intensity follow-up after cancer surgery does not reduce patient satisfaction or well-being

16 Mar, 2023 | 13:10h | UTC

Oncological surgery follow-up and quality of life: meta-analysis – British Journal of Surgery

 


Scanxiety among adults with cancer: a scoping review to guide research and interventions

14 Mar, 2023 | 13:55h | UTC

Summary: The article presents a scoping review of existing literature on scanxiety, which refers to the anxiety and distress experienced by cancer patients before and after medical imaging scans. The authors identified and synthesized findings from 36 articles on scanxiety among adults diagnosed with current or prior cancer.

The authors observed that scanxiety is a prevalent issue throughout the cancer continuum and may be linked to various factors related to the procedure itself or the uncertainty surrounding the possible outcomes of the scans.

The waiting period between the scan procedure and receipt of the results was described as particularly stressful, with participants reporting feeling overwhelmed by negative thoughts and fears about the potential outcomes of the scan. Some participants even found it difficult to focus on daily activities or responsibilities during this time.

The authors suggest that implementing supportive measures during scan experiences, including examining the waiting period between scans and scan results, could enhance the well-being for individuals with cancer who are going through different stages of treatment.

Article: Scanxiety among Adults with Cancer: A Scoping Review to Guide Research and Interventions – Cancers

 


SR | Environmental interventions can reduce falls in high-risk older adults

14 Mar, 2023 | 13:58h | UTC

Summary: Falls and fall-related injuries are common among older adults and can have serious consequences, such as restricting activity or institutionalization. The Cochrane review aimed to assess the effects of environmental interventions, such as fall-hazard reduction, assistive technology, home modifications, and education, on preventing falls in older adults living in the community.

The review included 22 randomized controlled trials from 10 countries involving 8,463 community-residing older people. The study found that home fall-hazard interventions, which involve evaluating potential fall hazards and implementing safety adaptations or behavioral strategies, can reduce the rate of falls by 26% and the number of people who experience one or more falls by 11% in people at a higher risk of falling.

On the other hand, the study did not find any evidence of a decrease in the rate of falls when the interventions were not targeted toward individuals at higher risk. Additionally, the study suggests that these interventions are unlikely to have a significant impact on health-related quality of life, and there may be little or no difference in the risk of fall-related fractures, hospitalizations due to falls, or the rate of falls that require medical attention.

Article: Environmental interventions for preventing falls in older people living in the community – Cochrane Library

Summary: Reducing fall hazards within the environment – Cochrane Library

Editorial: Preventing falls in older people: the evidence for environmental interventions and why history matters – Cochrane Library

Commentary: Preventing falls in older people: new evidence on what helps – Evidently Cochrane

 


Hospitalist comanagement reduces patients’ length of stay and improves oncologist experience, preliminary evidence suggests

13 Mar, 2023 | 14:33h | UTC

Outcomes on an inpatient oncology service after the introduction of hospitalist comanagement – Journal of Hospital Medicine (link to abstract – $ for full-text)

News Release: Involving hospitalists in inpatient cancer care reduces patient stays, oncologist stress – Yale School of Medicine

 


Perspective | Diagnostic stewardship to prevent diagnostic error

6 Mar, 2023 | 14:18h | UTC

Diagnostic Stewardship to Prevent Diagnostic Error – JAMA (free for a limited period)

 

Commentary on Twitter

 


An overview of systematic reviews and meta-analyses on the effect of medication interventions targeting polypharmacy for frail older adults

3 Mar, 2023 | 14:07h | UTC

Summary: This overview of published systematic reviews examined the effectiveness of medication reviews on managing polypharmacy in frail older adults. The overview identified 10 systematic reviews, which included 154 studies. Medication reviews were the most common intervention, and the evidence suggests that they help reduce inappropriate medication use in frail older adults, but their impact on frailty scores and hospital admission is unclear. Pharmacist-led medication interventions were the most common, reducing inappropriate prescriptions in various settings. Tools, such as clinical decision-making computer support tools, were also found to be effective. The evidence quality ranged from moderate to critically low, highlighting the need for further research to establish if interventions directed at polypharmacy could have an impact on frailty syndromes.

Article: An Overview of Systematic Reviews and Meta-Analyses on the Effect of Medication Interventions Targeting Polypharmacy for Frail Older Adults – Journal of Clinical Medicine

Related:

Physician-led medication reviews in polypharmacy patients treated with at least 12 medications in a type 2 diabetes outpatient clinic: a randomised trial – Diabetic Medicine

RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care

Achieving sustainable healthcare through deprescribing of unnecessary medications: making sense of the evidence – Cochrane Library

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Barriers and facilitators to deprescribing of cardiovascular medications: a systematic review – BMJ Open

A National Modified Delphi Consensus Process to Prioritize Experiences and Interventions for Antipsychotic Medication Deprescribing Among Adult Patients With Critical Illness – Critical Care Explorations

Deprescribing proton pump inhibitors – Australian Journal of General Practice

Medication reviews and deprescribing as a single intervention in falls prevention: a systematic review and meta-analysis – Age and Ageing

Optimizing Medication Use in Older Adults With Rheumatic Musculoskeletal Diseases: Deprescribing as an Approach When Less May Be More – ACP Open Rheumatology

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

 


Physicians are more burned out than ever — here’s what can be done about it

28 Feb, 2023 | 13:57h | UTC

Physicians Are More Burned Out Than Ever—Here’s What Can Be Done About It – JAMA (free for a limited period)

Related Report: Addressing Health Worker Burnout – The U.S. Surgeon General’s Advisory on Building a Thriving Health Workforce

Related:

AAP Clinical Report | Physician health and wellness.

M-A | Physicians suffering burnout are twice as likely to be involved in patient safety incidents.

Systematic Review | Predictors of burnout among healthcare providers.

Prevalence of burnout among GPs: a systematic review and meta-analysis – British Journal of General Practice

Physician Well-being 2.0: Where Are We and Where Are We Going? – Mayo Clinic Proceedings

Consensus Study – Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being – National Academies of Medicine

Consensus Study – Taking Action Against Clinician Burnout: A Systems Approach to Professional Well-Being – National Academies of Medicine

Assessment of Risk Factors for Suicide Among US Health Care Professionals

Beyond Burnout: Docs Decry ‘Moral Injury’ From Financial Pressures of Health Care

Hospital administration response to physician stress and burnout – Journal of Hospital Practice

Opinion: It’s Time to Talk About Physician Burnout and Moral Injury

Systematic Review: Effect of Organization-Directed Workplace Interventions on Physician Burnout

The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution) – Forbes

Physician Burnout: A Global Crisis

The Burnout Crisis in American Medicine – The Atlantic

To Combat Physician Burnout and Improve Care, Fix the Electronic Health Record – Harvard Business Review

Physician burnout costs up to $17B a year, task force says – HealthcareDive

Systematic Review: Prevalence of Burnout Among Physicians

Prevalence of Burnout in Medical and Surgical Residents: A Meta-Analysis – International Journal of Environmental Research and Public Health

Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction

 


Fatal accident calls MRI safety standards into question—are more regulations needed?

28 Feb, 2023 | 13:44h | UTC

Fatal accident calls MRI safety standards into question—are more regulations needed? – Health Imaging

 


Perspective | Beware of overdiagnosis harms from screening, lower diagnostic thresholds, and incidentalomas

27 Feb, 2023 | 13:18h | UTC

Summary: This article discusses the concept of overdiagnosis and its relevance to clinical practice guidelines. Overdiagnosis is the diagnosis of a condition that, if unrecognized, would not result in symptoms or cause a patient harm during their lifetime, such as discovering a low-grade cancer that will never lead to symptoms at the end of life. But, unlike false positives, overdiagnosed individuals truly have the condition; they just don’t benefit from the diagnosis. Overdiagnosis can also result from lowering diagnostic thresholds for diagnosing a disease, which inflates diagnosis rates among patients and leads to recommendations for subsequent interventions without clear benefits. The article highlights the importance of providing accurate information to patients about the possibility and burden of overdiagnosis to inform shared decision-making and minimize the harms of screening interventions.

Article: Beware of overdiagnosis harms from screening, lower diagnostic thresholds, and incidentalomas – Canadian Family Physician

Related:

Editorial: Chance Encounters, Overdiagnosis, and Overtreatment – Clinical Orthopaedics and Related Research

Broadening risk factor or disease definition as a driver for overdiagnosis: A narrative review – Journal of Internal Medicine

Overdiagnosis: it’s official – The BMJ

Overdiagnosis: what it is and what it isn’t – BMJ Evidence Based Medicine

Overdiagnosis across medical disciplines: a scoping review – The BMJ Open

Too much medical care: bad for you, bad for health care systems – STAT News

Overdiagnosis: causes and consequences in primary health care – Canadian Family Physician

Five warning signs of overdiagnosis – The Conversation

What is overdiagnosed cancer? And why does it matter? – Croakey

Blame rising cancer overdiagnosis on ‘irrational exuberance’ for early detection – STAT

Preventing overdiagnosis and the harms of too much sport and exercise medicine – British Journal of Sports Medicine

Study shows that current definitions of chronic kidney disease overestimate the CKD burden in older individuals and results in overdiagnosis.

Opinion | More kids are being diagnosed with ADHD for borderline (yet challenging) behaviors. Our new research shows why that’s a worry

A food allergy epidemic… or just another case of overdiagnosis?

An epidemic of overdiagnosis: Melanoma diagnoses sky rocket

 


Innovative models of healthcare delivery: an umbrella review of reviews

27 Feb, 2023 | 12:37h | UTC

Innovative models of healthcare delivery: an umbrella review of reviews – BMJ Open

 


Cluster RCT | Effect of an antibiotic stewardship intervention to improve antibiotic prescribing for suspected UTI in older adults

24 Feb, 2023 | 13:58h | UTC

Summary: The study evaluated the effectiveness of a multifaceted antibiotic stewardship intervention to improve antibiotic prescribing for suspected urinary tract infections (UTI) in frail older adults. The study was a pragmatic, parallel, cluster-randomized controlled trial conducted in four European countries and included 1041 frail older adults aged 70 or older. The intervention involved a decision tool for appropriate antibiotic use, supported by a toolbox with educational materials. The control group provided care as usual. The primary outcome was the number of antibiotic prescriptions for suspected UTI per person year, and secondary outcomes included incidence of complications, hospital referrals, admissions, and mortality. The results showed that the intervention group had a lower rate of receiving an antibiotic prescription for a suspected UTI (0.27 per person year) compared to the control group (0.58 per person year), with no increase in complications or adverse events.

Article: Effect of a multifaceted antibiotic stewardship intervention to improve antibiotic prescribing for suspected urinary tract infections in frail older adults (ImpresU): pragmatic cluster randomised controlled trial in four European countries – The BMJ

Commentary: Trial: Stewardship intervention cuts antibiotic prescribing for suspected urinary infections – CIDRAP

Related:

Case-Control Study | Current pyuria cut-offs may promote inappropriate UTI diagnosis in older women

Bacteriuria in older adults triggers confusion in healthcare providers: A mindful pause to treat the worry – Antimicrobial Stewardship & Healthcare Epidemiology

Antibiotics versus no treatment for asymptomatic bacteriuria in residents of aged care facilities: a systematic review and meta-analysis – British Journal of General Practice

USPSTF Recommendation Statement: Screening for Asymptomatic Bacteriuria in Adults

Most doctors still believe in prescribing unnecessary antibiotics to treat asymptomatic bacteriuria, study suggests.

Randomized trial: Antibiotics vs. no therapy in kidney transplant recipients with asymptomatic bacteriuria

 


M-A | Global and regional prevalence of multimorbidity in the adult population in community settings

22 Feb, 2023 | 12:47h | UTC

Summary: The article presents a systematic review and meta-analysis of surveys that estimate the prevalence of multimorbidity among adults in community settings. The study analyzed data from 126 peer-reviewed studies, including nearly 15.4 million people from 54 countries worldwide. The overall global prevalence of multimorbidity was 37.2%, with South America having the highest prevalence, followed by North America, Europe, and Asia. The study also found that females have a higher prevalence of multimorbidity than males, and that more than half of the adult population worldwide above 60 years of age had multimorbid conditions.

Article: Global and regional prevalence of multimorbidity in the adult population in community settings: a systematic review and meta-analysis – eClinicalMedicine

Related:

Comparison of 6 Mortality Risk Scores for Prediction of 1-Year Mortality Risk in Older Adults With Multimorbidity – JAMA Network Open

Costs of multimorbidity: a systematic review and meta-analyses – BMC Medicine

Variation in the estimated prevalence of multimorbidity: systematic review and meta-analysis of 193 international studies – BMJ Open

Italian guidelines on management of persons with multimorbidity and polypharmacy – Aging Clinical and Experimental Research

Management of High-Need, High-Cost Patients: A “Best Fit” Framework Synthesis, Realist Review, and Systematic Review – Agency for Healthcare Research and Quality

Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers – The Commonwealth fund

Effective Care for High-Need Patients: Opportunities for Improving Outcomes, Value, and Health – National Academy of Medicine

Systematic review of high-cost patients’ characteristics and healthcare utilization – BMJ Open

Effectiveness of interventions for managing multiple high-burden chronic diseases in older adults: a systematic review and meta-analysis – Canadian Medical Association Journal

Multimorbidity: a priority for global health research – The Academy of Medical Sciences

The global burden of multiple chronic conditions: a narrative review – Preventive Medicine Reports

Redesigning Care for High-Cost, High-Risk Patients – Harvard Business Review

Multimorbidity: clinical assessment and management – NICE Guideline

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Richard Smith: The challenge of high need, high cost patients – The BMJ Blogs

Better Care for People with Complex Needs – Institute for Healthcare Improvement

 


Gadolinium nanoparticles detected in kidney tissue of patients after MRI with gadolinium contrast, raising safety concerns

20 Feb, 2023 | 12:24h | UTC

Summary: Researchers have discovered that tiny particles of the rare earth metal gadolinium can infiltrate kidney cells, potentially causing side effects. These particles, used to enhance MRI scans, were found in human and rodent specimens in a study that used electron microscopy to detect them. Gadolinium is typically tightly bound to chelating molecules in MRI contrast agents so that it can be eliminated via the kidneys, but the researchers found that some particles can leach out and build up in tissues. This raises questions about the safety of contrast agents containing gadolinium, which are used in around 50% of MRI scans, and highlights the need for further research into the risks and potential harms associated with these agents.

Article: The onset of rare earth metallosis begins with renal gadolinium-rich nanoparticles from magnetic resonance imaging contrast agent exposure – Scientific Reports

News Release: UNM Researchers Find Nanoparticles of Gadolinium, a Rare Earth Metal Used in MRI Contrast Agents, Can Infiltrate Kidney Tissue – University of New Mexico

Commentary: Expert left ‘astounded’ by gadolinium discovery – Health Imaging

 


Digital health interventions for adult patients with cancer evaluated in randomized controlled trials: scoping review

16 Feb, 2023 | 14:45h | UTC

Digital Health Interventions for Adult Patients With Cancer Evaluated in Randomized Controlled Trials: Scoping Review – Journal of Medical Internet Research

 


Editorial | Top-down and bottom-up approaches to low-value care

15 Feb, 2023 | 16:08h | UTC

Top-down and bottom-up approaches to low-value care = BMJ Quality & Safety

Original Study: Evaluation of the NHS England evidence-based interventions programme: a difference-in-difference analysis – BMJ Quality & Safety

 

Commentary on Twitter

 


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