Safety and efficacy of aspirin for primary prevention of cancer: a meta-analysis of randomized controlled trials – Journal of Cancer Research and Clinical Oncology (free)

“Our study did not find any significant reductions in cancer-related mortality or cancer incidence when compared aspirin use with placebo or no aspirin.”


Randomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast Cancer – Journal of the American College of Cardiology (link to abstract – $ for full-text)

“In patients with HER2-positive breast cancer treated with trastuzumab, both lisinopril and carvedilol prevented cardiotoxicity in patients receiving anthracyclines.”


Cancer Control in Low- and Middle-Income Countries: Is It Time to Consider Screening? – Journal of Global Oncology (free)

“the placement of priority on early detection cannot be assumed to be effective in LMICs, where limited downstream resources may be overwhelmed by the inevitable increases in number of diagnoses.”


Effect of Vein-First vs Artery-First Surgical Technique on Circulating Tumor Cells and Survival in Patients With Non–Small Cell Lung Cancer: A Randomized Clinical Trial and Registry-Based Propensity Score Matching Analysis – JAMA Surgery (link to abstract – $ for full-text)

Source: EvidenceAlerts


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The Development of Pathways in Palliative Medicine: Definition, Models, Cost and Quality Impact – Healthcare (free) (via @Abraham_RMI)


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Association of Treatment With 5α-Reductase Inhibitors With Time to Diagnosis and Mortality in Prostate Cancer – JAMA Internal Medicine (free for a limited period)

Commentary: 5-ARIs Tied to Delayed Prostate Cancer Dx, Worse Outcomes – MedPage Today (free registration required)


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ESMO Guideline: Renal Cell Carcinoma

2 May, 2019 | 12:56h | UTC

Risk‐reducing medications for primary breast cancer: a network meta‐analysis – Cochrane Library (free)

Summary: Medicines to prevent breast cancer in women at above-average risk of developing breast cancer – Cochrane Library (free)


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Active Surveillance of Low-Risk Thyroid Cancer – JAMA (free for a limited period)

“Individuals should also be aware that there are currently no head-to-head randomized trials that compared active surveillance of low-risk thyroid cancer with thyroid surgery, and that there remain uncertainties related to the risks and benefits of each approach.”


Guidelines for the Treatment of Adults with Metastatic Brain Tumors – Congress of Neurological Surgeons (free)

Comprehensive resource on the subject with 9 guidelines covering important aspects of patient care.


Review: Tumoral Pulmonary Hypertension

20 Apr, 2019 | 14:43h | UTC

Treatment of Nonmetastatic Breast Cancer – JAMA (free for a limited period)

A short review on the subject.


NCCN Guideline: Cutaneous Melanoma

10 Apr, 2019 | 22:25h | UTC

NICE Guideline: Lung Cancer

29 Mar, 2019 | 07:54h | UTC

Long-Term Risk of Heart Failure in Breast Cancer Patients After Adjuvant Chemotherapy With or Without Trastuzumab – JACC: Heart Failure (link to abstract – $ for full-text) (via @md_arianemacedo)

Commentary: Long-Term Risk of Heart Failure After Chemotherapy With Trastuzumab – American College of Cardiology (free)

“Trastuzumab treatment is associated with a 2-fold increased risk of late HF compared with chemotherapy treatment alone.”


NCCN Guidelines Insights: Breast Cancer

27 Feb, 2019 | 12:41h | UTC

Management of Cardiovascular Disease in Women With Breast Cancer – Circulation (free)

Related: AHA Scientific Statement on Cardio-Oncology (several guidelines on the subject)


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Review: Diagnosis of Prostate Cancer

16 Feb, 2019 | 18:18h | UTC

Should we rename low risk cancers? – The BMJ (free)


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Study: Suicide Among Cancer Patients

15 Jan, 2019 | 00:13h | UTC

Cancer Statistics, 2019

10 Jan, 2019 | 18:57h | UTC

A systematic review of trial-level meta-analyses measuring the strength of association between surrogate end-points and overall survival in oncology – European Journal of Cancer (free for a limited period)

“we found most surrogates in oncology had low or modest correlation with OS, which suggests that caution should be used when making conclusions based on surrogate markers.”


NCCN Guideline: Thyroid Carcinoma

9 Jan, 2019 | 09:56h | UTC

Association Between Reimbursement Incentives and Physician Practice in Oncology: A Systematic Review (link to abstract – $ for full-text)


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