Adjuvant hyperthermic intraperitoneal chemotherapy in patients with locally advanced colon cancer (COLOPEC): a multicentre, open-label, randomised trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)


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NCCN Guideline: Adult Cancer Pain

9 Aug, 2019 | 08:12h | UTC

Comparison of Multiparametric Magnetic Resonance Imaging and Targeted Biopsy With Systematic Biopsy Alone for the Diagnosis of Prostate Cancer: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: The Evolving Paradigm of Prostate Cancer Screening – JAMA Network Open (free) AND MRIs Improve Targeting of Biopsies for Prostate Cancer Diagnosis – MedicalResearch.com (free)

Related Cochrane Review: MRI Pathway vs. Systematic Biopsy for Detecting Prostate Cancer (free)

“Prebiopsy magnetic resonance imaging combined with targeted biopsy is associated with improved detection of clinically significant prostate cancer and reduced numbers of biopsy cores per procedure, while potentially avoiding unnecessary biopsies.”


The global burden of childhood and adolescent cancer in 2017: an analysis of the Global Burden of Disease Study 2017 – The Lancet Oncology (free)

Commentaries: Global burden of childhood cancer: growing, but controllable – The Lancet Oncology (free) AND Globally, more than 11 million years of healthy life lost due to childhood cancer in 2017 – The Lancet (free)


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Doctors: How Job Stress Can Age Us

31 Jul, 2019 | 01:59h | UTC

Choosing Wisely India: ten low-value or harmful practices that should be avoided in cancer care – The Lancet Oncology (free registration required)

Commentary: 10 Ways to Improve the Value of Cancer Care – Medscape (free registration required)

See other lists of low-value practices in oncology:

– American Society of Clinical Oncology

– Society of Surgical Oncology

– Society of Gynecologic Oncology

– American Society for Radiation Oncology

– Medical Oncology Group of Australia

– Oncology – Choosing Wisely Canada

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada


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Assessment of Deep Natural Language Processing in Ascertaining Oncologic Outcomes From Radiology Reports – JAMA Oncology (free for a limited period)

Commentaries: The Tipping Point for Deep Learning in Oncology – JAMA Oncology (free for a limited period) AND Deep Natural Language Processing of Oncology Radiology Reports – The ASCO Post (free)


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2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm: long-term follow-up of a multicentre, randomised trial – The Lancet (link to abstract – $ for full-text)

Commentaries: Does Size of Surgical Excision Margins for Thick Localized Cutaneous Melanoma Affect Survival Outcomes? – The ASCO Post (free) AND Quick Take: 2-cm versus 4-cm surgical excision margins for primary cutaneous melanoma thicker than 2 mm – 2 Minute Medicine (free)


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The Promise and Price of Cellular Therapies – The New Yorker (a few articles per month are free)

“New “living drugs”—made from a patient’s own cells—can cure once incurable cancers. But can we afford them?”


MRI versus mammography for breast cancer screening in women with familial risk (FaMRIsc): a multicentre, randomised, controlled trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: MRI Breast Screening Better for Women With Familial Cancer Risk – MedPage Today (free registration required)


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NCCN Guideline: Acute Myeloid Leukemia

2 Jul, 2019 | 01:16h | UTC

Estimation of Kidney Function in Oncology: Implications for Anticancer Drug Selection and Dosing – Clinical Journal of the American Society of Nephrology (free)

“In one retrospective study, approximately one half of kidney function–impaired patients with solid tumors who were receiving a drug that necessitated dose adjustments for kidney function received almost 50% of their prescriptions at standard doses”.


Ultra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer: 5-year outcomes of the HYPO-RT-PC randomised, non-inferiority, phase 3 trial – The Lancet (link to abstract – $ for full-text)


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ESMO Guideline: Early Breast Cancer

24 Jun, 2019 | 01:49h | UTC

Safety and efficacy of aspirin for primary prevention of cancer: a meta-analysis of randomized controlled trials – Journal of Cancer Research and Clinical Oncology (free)

“Our study did not find any significant reductions in cancer-related mortality or cancer incidence when compared aspirin use with placebo or no aspirin.”


Randomized Trial of Lisinopril Versus Carvedilol to Prevent Trastuzumab Cardiotoxicity in Patients With Breast Cancer – Journal of the American College of Cardiology (link to abstract – $ for full-text)

“In patients with HER2-positive breast cancer treated with trastuzumab, both lisinopril and carvedilol prevented cardiotoxicity in patients receiving anthracyclines.”


Cancer Control in Low- and Middle-Income Countries: Is It Time to Consider Screening? – Journal of Global Oncology (free)

“the placement of priority on early detection cannot be assumed to be effective in LMICs, where limited downstream resources may be overwhelmed by the inevitable increases in number of diagnoses.”


Effect of Vein-First vs Artery-First Surgical Technique on Circulating Tumor Cells and Survival in Patients With Non–Small Cell Lung Cancer: A Randomized Clinical Trial and Registry-Based Propensity Score Matching Analysis – JAMA Surgery (link to abstract – $ for full-text)

Source: EvidenceAlerts


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The Development of Pathways in Palliative Medicine: Definition, Models, Cost and Quality Impact – Healthcare (free) (via @Abraham_RMI)


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Association of Treatment With 5α-Reductase Inhibitors With Time to Diagnosis and Mortality in Prostate Cancer – JAMA Internal Medicine (free for a limited period)

Commentary: 5-ARIs Tied to Delayed Prostate Cancer Dx, Worse Outcomes – MedPage Today (free registration required)


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ESMO Guideline: Renal Cell Carcinoma

2 May, 2019 | 12:56h | UTC

Risk‐reducing medications for primary breast cancer: a network meta‐analysis – Cochrane Library (free)

Summary: Medicines to prevent breast cancer in women at above-average risk of developing breast cancer – Cochrane Library (free)


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Active Surveillance of Low-Risk Thyroid Cancer – JAMA (free for a limited period)

“Individuals should also be aware that there are currently no head-to-head randomized trials that compared active surveillance of low-risk thyroid cancer with thyroid surgery, and that there remain uncertainties related to the risks and benefits of each approach.”


Guidelines for the Treatment of Adults with Metastatic Brain Tumors – Congress of Neurological Surgeons (free)

Comprehensive resource on the subject with 9 guidelines covering important aspects of patient care.


Review: Tumoral Pulmonary Hypertension

20 Apr, 2019 | 14:43h | UTC

Treatment of Nonmetastatic Breast Cancer – JAMA (free for a limited period)

A short review on the subject.


NCCN Guideline: Cutaneous Melanoma

10 Apr, 2019 | 22:25h | UTC

NICE Guideline: Lung Cancer

29 Mar, 2019 | 07:54h | UTC

Long-Term Risk of Heart Failure in Breast Cancer Patients After Adjuvant Chemotherapy With or Without Trastuzumab – JACC: Heart Failure (link to abstract – $ for full-text) (via @md_arianemacedo)

Commentary: Long-Term Risk of Heart Failure After Chemotherapy With Trastuzumab – American College of Cardiology (free)

“Trastuzumab treatment is associated with a 2-fold increased risk of late HF compared with chemotherapy treatment alone.”


NCCN Guidelines Insights: Breast Cancer

27 Feb, 2019 | 12:41h | UTC

Management of Cardiovascular Disease in Women With Breast Cancer – Circulation (free)

Related: AHA Scientific Statement on Cardio-Oncology (several guidelines on the subject)


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