Oncology

ESMO Guideline: Marginal Zone Lymphomas

14 Jan, 2020 | 00:26h | UTC

Breast Conservation After Neoadjuvant Chemotherapy for Triple-Negative Breast Cancer: Surgical Results From the BrighTNess Randomized Clinical Trial – JAMA Surgery (free for a limited period)

Commentary: Despite effective therapy, US rate of breast conservation lower than other countries – Brigham and Women’s Hospital (free)

 

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Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis – The Lancet Global Health (free)

 

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Olanzapine 5 mg plus standard antiemetic therapy for the prevention of chemotherapy-induced nausea and vomiting (J-FORCE): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)

 

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Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial – The Lancet (link to abstract – $ for full-text)

 

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External beam accelerated partial breast irradiation versus whole breast irradiation after breast conserving surgery in women with ductal carcinoma in situ and node-negative breast cancer (RAPID): a randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Results mixed for twice-daily APBI in early breast cancer – MedicalXpress (free)

 

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Long-term primary results of accelerated partial breast irradiation after breast-conserving surgery for early-stage breast cancer: a randomised, phase 3, equivalence trial – The Lancet (link to abstract – $ for full-text)

 

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Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial – JAMA (free for a limited period)

 

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British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland/Public Health England post-polypectomy and post-colorectal cancer resection surveillance guidelines – Gut (free)

Related Studies: Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence – JAMA (free) AND Long-term Risk of Colorectal Cancer and Related Death After Adenoma Removal in a Large, Community-based Population – Gastroenterology (link to abstract – $ for full-text) AND Baseline Colonoscopy Findings Associated with 10-Year Outcomes in a Screening Cohort Undergoing Colonoscopy Surveillance – Gastroenterology (link to abstract – $ for full-text)

Related Reviews: Optimizing post‐polypectomy surveillance: A practical guide for the endoscopist – Digestive Endoscopy (free) AND Optimal Colonoscopy Surveillance Interval after Polypectomy – Clinical Endoscopy (free)

Related Guidelines: Endoscopic surveillance after surgical or endoscopic resection for colorectal cancer: European Society of Gastrointestinal Endoscopy (ESGE) and European Society of Digestive Oncology (ESDO) Guideline – Endoscopy (free) AND Guidelines for Colonoscopy Surveillance After Screening and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer (free) AND Korean Guidelines for Postpolypectomy Colonoscopy Surveillance – Digestive Endoscopy (free) AND Colorectal cancer surveillance after index colonoscopy: Guidance from the Canadian Association of Gastroenterology (free) AND Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline (free)

 


Ten-year Mortality, Disease Progression, and Treatment-related Side Effects in Men with Localised Prostate Cancer from the ProtecT Randomised Controlled Trial According to Treatment Received – European Urology (free)

Original Study: 10-Year Outcomes after Monitoring, Surgery, or Radiotherapy for Localized Prostate Cancer – New England Journal of Medicine (free)

 

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Supplemental MRI Screening for Women with Extremely Dense Breast Tissue – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Does MRI Screening Benefit Women With Extremely Dense Breasts? – U.S. News (free) AND Mixed Results With Mammo Plus MRI Screening – MedPage Today (free)

“The benefits need to be carefully weighed against the harms, as MRI examination is more expensive, and it requires the injection of a contrast agent into the body. MRI will also detect abnormalities that later turn out not to be breast cancer after all” (from U.S News)

 

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Survival outcomes after laparoscopy-assisted distal gastrectomy versus open distal gastrectomy with nodal dissection for clinical stage IA or IB gastric cancer (JCOG0912): a multicentre, non-inferiority, phase 3 randomised controlled trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)

 

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Outcomes at follow-up of negative colonoscopy in average risk population: systematic review and meta-analysis – The BMJ (free)

Related Guidelines: ACP Guideline: Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults (free) AND BMJ Guideline: Colorectal Cancer Screening with Fecal Immunochemical Testing, Sigmoidoscopy or Colonoscopy (new guideline suggesting a more selective approach to screening) AND Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society (recent guideline with recommendation to start screening at 45 years, with links to guidelines from other organizations)

“Our findings suggest that 10 year intervals for colonoscopy screening after a negative colonoscopy, as currently recommended, may be adequate”

 


NCCN Guidelines Insights: Kidney Cancer

10 Nov, 2019 | 12:49h | UTC

The Global Burden of Pancreatic Cancer

30 Oct, 2019 | 07:59h | UTC

The global, regional, and national burden of pancreatic cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: Pancreatic cancer: a growing burden (free)

 

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The Global Burden of Gastric Cancer

30 Oct, 2019 | 07:57h | UTC

The global, regional, and national burden of stomach cancer in 195 countries, 1990–2017: a systematic analysis for the Global Burden of Disease study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: 27 years of stomach cancer: painting a global picture (free)

 

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The Global Burden of Colorectal Cancer

30 Oct, 2019 | 07:55h | UTC

The global, regional, and national burden of colorectal cancer and its attributable risk factors in 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Gastroenterology & Hepatology (free)

Invited Commentary: The global challenge of colorectal cancer (free)

 

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Older Patients (Still) Left Out of Cancer Clinical Trials – JAMA (free for a limited period)

Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)

 

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Trends in Internet Searches for Cannabidiol (CBD) in the United States – JAMA Network Open (free)

Commentaries: Interest in CBD products keeps soaring, but health experts wary – HealthDay (free) AND Online Searches For CBD Skyrocket – MedicalResearch.com (free)

 

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The Cancer Atlas

20 Oct, 2019 | 23:09h | UTC

NCCN Guideline: Distress Management

10 Oct, 2019 | 09:06h | UTC

ESMO Guideline: Thyroid Cancer

7 Oct, 2019 | 00:52h | UTC

Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a clinical practice guideline – The BMJ (free)

Editorial: Personalised and risk based cancer screening (free)

Related Study: Colorectal cancer screening with faecal immunochemical testing, sigmoidoscopy or colonoscopy: a microsimulation modelling study – The BMJ (free)

Commentaries: Guideline Moves Away from Colorectal Cancer Screening for Some – NEJM Journal Watch (free) AND First Guideline to Say Colon Cancer Screening Is Not for All – Medscape (free registration required)

Related Guidelines: Colorectal Cancer Screening for Average‐risk Adults (guidelines from other organizations)

 

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Global Burden of Cancer, 1990 to 2017

30 Sep, 2019 | 00:42h | UTC

Global, Regional, and National Cancer Incidence, Mortality, Years of Life Lost, Years Lived With Disability, and Disability-Adjusted Life-Years for 29 Cancer Groups, 1990 to 2017: A Systematic Analysis for the Global Burden of Disease Study – JAMA Oncology (free)

 

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Five-Year Survival with Combined Nivolumab and Ipilimumab in Advanced Melanoma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Skin cancer: Half of people surviving advanced melanoma – BBC (free) AND Combination immunotherapy drugs herald new hope for melanoma patients with long term survival rates – The Royal Marsden NHS Foundation Trust (free)

#ESMO19 – Just presented at the European Society of Medical Oncology Congress 2019 in Barcelona

 

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Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Two immunotherapy drug combination offers chemotherapy-free option for advanced NSCLC – European Society for Medical Oncology (free) AND Nivolumab/Low-dose Ipilimumab: A Potential Chemotherapy-Sparing Option in Advanced NSCLC – Pharmacy Times (free)

#ESMO19 – Just presented at the European Society of Medical Oncology Congress 2019 in Barcelona

 

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Efficacy of Neurohormonal Therapies in Preventing Cardiotoxicity in Patients With Cancer Undergoing Chemotherapy – JACC CardioOncology (free)

 

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Liquid versus tissue biopsy for detecting acquired resistance and tumor heterogeneity in gastrointestinal cancers – Nature Medicine (link to abstract – $ for full-text)

Commentary: Liquid biopsies reveal genetic alterations linked to cancer drug resistance – Broad Institute of MIT and Harvard (free)

 

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Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (ICBP SURVMARK-2): a population-based study – The Lancet Oncology (free)

Commentaries: Cancer Patients in Rich Countries Are Gaining Years, Study Shows – Bloomberg (free) AND Cancer survival in high income countries is improving but international disparities persist – eCancer News (free)

 

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Effects of Helicobacter pylori treatment and vitamin and garlic supplementation on gastric cancer incidence and mortality: follow-up of a randomized intervention trial – The BMJ (free)

 

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