Open access

NEWS - Oncology

#ACC18 – Carvedilol for Prevention of Chemotherapy Related Cardiotoxicity – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Beta Blocker Shows Mixed Results in Protecting Against Chemo-Induced Heart Damage – American College of Cardiology (free) AND Carvedilol Effect in Preventing Chemotherapy Induced CardiotoxicitY – CECCY – American College of Cardiology (free)

Related study from #ACC18: Heart Drugs Prevented Cardiotoxicity in Breast Cancer Treated With Anthracycline and Trastuzumab – American College of Cardiology (free)

“According to the CECCY trial, carvedilol had no effect on left ventricular function in breast cancer patients treated w/ doxorubicin, but did result in a reduction in troponin I levels & diastolic dysfunction”. (via @ACCinTouch see Tweet)


Effect of a Low-Intensity PSA-Based Screening Intervention on Prostate Cancer Mortality: The CAP Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: One-off PSA screening for prostate cancer does not save lives – eCancer News (free)

“Largest ever prostate cancer trial – CAP – published in the JAMA. No effect from low intensity PSA screening on prostate cancer mortality at 10 years”. (via @KariTikkinen see Tweet)


Apalutamide Treatment and Metastasis-free Survival in Prostate Cancer – New England Journal of Medicine (free)

“Apalutamide improves castration resistant prostate CA survival compared with… placebo. Why wasn’t it compared w bicalutamide?” (via @RichardLehman1 see Tweet). See Richard Lehman’s point of view


Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Hyperthermic intraperitoneal chemotherapy with surgery increases survival for epithelial ovarian cancer patients – 2 Minute Medicine (free) AND Add-On Hyperthermic Intraperitoneal Chemotherapy Assessed in Ovarian CA – MPR (free)

Patients treated with hyperthermic intraperitoneal chemotherapy associated with surgery had increased median overall survival compared to patients treated with surgery alone (45,7 months vs 33,9 months).


The Right Place at the Right Time: Medical Oncology Outpatients’ Perceptions of Location of End-of-Life Care – JNCCN (free)

Commentary: Let’s Talk About End-of-Life Care – National Comprehensive Cancer Network, via NewsWise (free)

“…majority of people with cancer would like their physicians to ask them where they would prefer to receive end-of-life care” (from NewsWise).


Effect of an Indwelling Pleural Catheter vs Talc Pleurodesis on Hospitalization Days in Patients With Malignant Pleural Effusion: The AMPLE Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Treatment with pleural catheter resulted in fewer hospitalization days from treatment to death (median, 10 vs 12 days).


The struggle to do no harm in clinical trials – Nature (free)

“The struggle to do no harm: the unexplained deaths in #cancer immunotherapy trials” (via @EricTopol see Tweet)


Does Cancer Screening Save More Lives Overall? Not Necessarily – WBUR (free) (via @HealthNewsRevu see Tweet)

Related systematic review: Does screening for disease save lives in asymptomatic adults? Systematic review of meta-analyses and randomized trials – International Journal of Epidemiology (free)

“We are not suggesting that cancer screening is useless. Our critique aims to show that screening tests are like any other medical intervention: there are benefits and harms.  And it’s why we support informed decision-making”.


Taking Care of the Physician – The New York Times (10 articles per month are free)


Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study – The BMJ (free)

Commentary: Vitamin D level not associated with cancer risk – Clinical Adviser (free)

“These results, in combination with previous literature, provide evidence that population-wide screening for vitamin D deficiency and subsequent widespread vitamin D supplementation should not currently be recommended as a strategy for primary cancer prevention”.


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