Nutrition (all articles)
SR | Probiotics for management of functional abdominal pain disorders in children
22 Feb, 2023 | 12:20h | UTCProbiotics for management of functional abdominal pain disorders in children – Cochrane Library
Trends and predictions of malnutrition and obesity in 204 countries and territories: an analysis of the Global Burden of Disease Study 2019
22 Feb, 2023 | 12:17h | UTC
RCT | Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease
20 Feb, 2023 | 12:27h | UTCSummary: The article reports on a randomized trial that compared the effects of alternate-day fasting (ADF) combined with exercise, fasting alone, or exercise alone in adults with obesity and non-alcoholic fatty liver disease (NAFLD). After three months, the combination of ADF and exercise significantly reduced intrahepatic triglyceride content, body weight, fat mass, waist circumference, and alanine transaminase levels compared to the control group. The intervention seems promising for patients with fatty liver disease who want to improve their health without using medications.
Article: Effect of alternate day fasting combined with aerobic exercise on non-alcoholic fatty liver disease: A randomized controlled trial – Cell Metabolism (link to abstract – $ for full-text)
News Release: Alternate-day fasting could be a good option for patients with fatty liver disease – University of Illinois Chicago
M-A | Consumption of whole vs. refined grains and risk of cardiovascular disease and all-cause mortality
20 Feb, 2023 | 12:23h | UTCSummary: This systematic review and meta-analysis of prospective cohort studies found that consuming whole grains was associated with a reduced risk of coronary heart disease, cardiovascular disease, and all-cause mortality, while consuming refined grains had no significant influence on these outcomes. Residual confounding can’t be excluded and the association found does not necessarily imply causation.
ESPEN practical guideline | Home parenteral nutrition
20 Feb, 2023 | 12:21h | UTCSummary: Home parenteral nutrition (HPN) is a form of nutrition support where a patient receives intravenous nutrition at home. It is used for patients who cannot receive adequate nutrition through oral or enteral routes, such as those with intestinal failure, severe inflammatory bowel disease, or other gastrointestinal disorders. HPN can be a life-saving therapy, but it requires careful patient selection, as well as ongoing monitoring and management by a multidisciplinary team. The ESPEN guideline aims to provide practical guidance on the use of HPN, including the nutritional and metabolic aspects of care and the practical considerations of administering HPN at home. The guideline also emphasizes the importance of patient-centered care and shared decision-making, highlighting the need for regular assessment and monitoring of patients.
Article: ESPEN practical guideline: Home parenteral nutrition – Clinical Nutrition
M-A | Soluble fiber supplementation and serum lipid profile
20 Feb, 2023 | 12:18h | UTCSummary: The article presents the results of a systematic review and dose-response meta-analysis of randomized controlled trials (RCTs) that evaluated the effect of soluble fiber supplementation on blood lipid parameters in adults. The review included 181 RCTs with 220 treatment arms and 14,505 participants. The meta-analysis found that soluble fiber supplementation significantly reduced LDL cholesterol, total cholesterol, triglycerides, and apolipoprotein B concentrations. The article suggests that increasing fiber intake using soluble fiber supplementation could be an effective intervention in the prevention and management of dyslipidemia, and consequently may contribute to the risk reduction of cardiovascular diseases. However, the article also notes that because of the high between-study heterogeneity and publication bias, the findings should be interpreted cautiously.
M-A | The rate and assessment of muscle wasting during critical illness
17 Feb, 2023 | 12:55h | UTC
Commentary on Twitter
A Review published in @Crit_Care analyzes the data of ICU muscle wasting studies and reports that critically ill patients lose nearly 2% of skeletal muscle per day during the first week of ICU admission.https://t.co/qW5jzbWRSk
— BMC (@BioMedCentral) January 8, 2023
RCT | Orlistat and a low-carb diet show promising results for the treatment of Metabolic-Associated Fatty Liver Disease
16 Feb, 2023 | 15:07h | UTCSummary: The study aimed to compare the effects of orlistat or a high-protein/lower-carbohydrate diet with a control diet in Asian patients with obesity and metabolic-associated fatty liver disease (MAFLD) over 24 weeks. The primary endpoint was the relative change in liver fat content (LFC) assessed by MRI-PDFF. A total of 118 patients were randomly assigned to the control group, orlistat group, or experimental diet group. All three groups demonstrated improvement in liver steatosis at week 24, with the orlistat group and the experimental diet group both showing a significant decrease in LFC compared to the control group.*
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
Perspective | A short history of saturated fat: the making and unmaking of a scientific consensus
16 Feb, 2023 | 14:57h | UTC
Commentary from the author on Twitter (thread – click for more)
My latest: "A short history of saturated fat: the making and unmaking of a scientific consensus"
Do saturated fats cause heart disease? The science was always weak. Fear of these fats was started by American Heart Assoc. in 1961 based on a flawed study?https://t.co/J3cOlfzTi6— Nina Teicholz (@bigfatsurprise) December 14, 2022
Review | Preoperative frailty screening, assessment and management
16 Feb, 2023 | 14:37h | UTCPreoperative frailty screening, assessment and management – Current Opinion in Anaesthesiology
Cohort Study | Associations between types and sources of dietary carbohydrates and cardiovascular disease risk
15 Feb, 2023 | 16:13h | UTCSummary: This study found that the associations between carbohydrate intake and cardiovascular disease risk depend on the type and source of carbohydrates consumed, with free sugar intake being associated with higher risk of total cardiovascular disease and stroke. Fiber intake was associated with lower risk, and replacing refined grain starch and free sugars with wholegrain starch and non-free sugars may be protective for cardiovascular disease. Free sugar intake was also associated with higher triglycerides and lipoprotein subclasses. As with all observational studies, this study cannot establish causality, but rather suggests associations between carbohydrate intake and cardiovascular disease risk, and the importance of considering the quality of carbohydrates consumed for cardiovascular health.*
News Release: Free sugars associated with higher risk of cardiovascular disease – BioMed Central
*Note: This summary was created through the collaboration of a medical editor and ChatGPT.
Study suggests long-term caloric restriction could slow biological aging in healthy adults
14 Feb, 2023 | 10:52h | UTCSummary: The article reports the results of a study that analyzed the impact of caloric restriction (CR), defined as reducing caloric intake without depriving essential nutrients, on DNA methylation, a measure of aging, in blood samples from the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial. The results showed that the CALERIE intervention slowed the pace of aging, as measured by the DunedinPACE DNAm algorithm, but did not lead to significant changes in biological age estimates measured by various DNAm clocks. The authors note that while treatment effect sizes were small, a modest slowing of the pace of aging can have a significant impact on population health. They also highlight the need for further trials with long-term follow-up to establish the effects of interventions on primary healthy-aging endpoints, including the incidence of chronic disease and mortality.
(By ChatGPT, reviewed and edited)
Commentaries:
Restrict calories to live longer, study says, but critics say more proof is needed – CNN
Single-arm study | Effects of SER-109 as an investigational microbiome therapeutic in recurrent C. difficile infection
14 Feb, 2023 | 10:47h | UTCSummary: This was a phase 3, open-label, single-arm trial of 263 adults with recurrent Clostridioides difficile Infection (CDI). The trial aimed to evaluate the safety and rate of CDI recurrence after administration of the investigational microbiome therapeutic SER-109. The trial found that SER-109 was well tolerated and the overall rate of recurrent CDI was low, regardless of the number of prior recurrences, demographics, or diagnostic approach.
(By ChatGPT, reviewed and edited)
Commentary: Phase 3 trial provides more positive data for recurrent C diff microbiome drug – CIDRAP
Related:
RCT | Consumption of 2 green kiwifruits daily improves constipation and abdominal comfort
10 Feb, 2023 | 13:39h | UTC
Research shows ad libitum meal energy intake is influenced by energy density, eating rate and hyper-palatable foods
8 Feb, 2023 | 12:36h | UTCAd libitum meal energy intake is positively influenced by energy density, eating rate and hyper-palatable food across four dietary patterns – Nature Food (free for a limited period)
News Release: Research shows impact of ‘hyper-palatable’ foods across four diets – University of Kansas
Commentary from one of the authors on Twitter (thread – click for more)
What determines how many calories people eat during a meal? Our new study, led by Tera Fazzino @UnivOfKansas, was just published in @NatureFoodJnl & investigated the meal characteristics that influence ad libitum energy intake. https://t.co/Of2IzddLRd
— Kevin Hall (@KevinH_PhD) January 30, 2023
ESPEN guideline on clinical nutrition in inflammatory bowel disease
7 Feb, 2023 | 14:02h | UTCESPEN guideline on Clinical Nutrition in inflammatory bowel disease – Clinical Nutrition
RCT | Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity
7 Feb, 2023 | 13:54h | UTC
Commentary on Twitter
Time-restricted eating (TRE) and high-intensity interval training (HIIT) both improve glucose control and reduce fat mass in people w/ obesity.
Combining TRE (<10 hour eating window) with 3 x weekly HIIT enhances these benefits.
?:https://t.co/m051O3AUPW pic.twitter.com/6q6mtzDwVB
— Brady Holmer (@B_Holmer) October 4, 2022
Under a Creative Commons Attribution – NonCommercial – NoDerivs (CC BY-NC-ND 4.0) license
Update guidelines for women with HIV who are virally suppressed incorporate breastfeeding their infants as a viable option
6 Feb, 2023 | 13:40h | UTC
Commentary on Twitter
Updated guidelines now incorporate breastfeeding options for PWH with suppressed VL on ART. https://t.co/JPR1K8zzv6
— Carlos del Rio (@CarlosdelRio7) February 3, 2023
M-A | Efficacy and safety of dietary therapies for childhood drug-resistant epilepsy
6 Feb, 2023 | 13:00h | UTCEfficacy and Safety of Dietary Therapies for Childhood Drug-Resistant Epilepsy: A Systematic Review and Network Meta-analysis – JAMA Pediatrics (link to abstract – $ for full-text)
Related:
Commentary on Twitter
Modified Atkins diet may have better tolerability and higher probability of short-term seizure reduction than ketogenic diet. https://t.co/B416ypjUWr
— JAMA Pediatrics (@JAMAPediatrics) January 30, 2023
APA Guideline for the treatment of patients with eating disorders
3 Feb, 2023 | 14:26h | UTCNews Release: APA Releases Updated Guideline for Treating Eating Disorders – American Psychiatric Association
RCT | Efficacy and safety of intermittent fasting in people with insulin-treated Type 2 Diabetes
3 Feb, 2023 | 13:54h | UTCCommentary: Intermittent fasting feasible with insulin-treated type 2 diabetes – medwire News
Related:
RCT | Effect of an intermittent calorie-restricted diet on Type 2 DM remission.
Intermittent fasting may be effective weight loss strategy in patients with type 2 diabetes
Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus
The introduction of sugary drinks tax in the UK was followed by a drop in obesity cases among children
1 Feb, 2023 | 13:32h | UTCNews Releases:
UK soft drink taxes associated with decreased obesity in girls – PLOS
Commentaries:
UK sugar tax ‘prevents 5,000 cases of obesity in year 6 girls annually’ – The Guardian
Related:
WHO manual on sugar-sweetened beverage taxation policies to promote healthy diets.
M-A: Outcomes following taxation of sugar-sweetened beverages.
Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents – Pediatrics
Cutting back on sugar-sweetened beverages: What works? – Cochrane Library
Sugar-sweetened beverage taxes: Lessons to date and the future of taxation – PLOS Medicine
Banning the promotion of soft drinks could be more effective than a sugar tax – The Conversation
Sugar tax: why health experts want it but politicians and industry are resisting – The Guardian
Commentary from the author on Twitter (thread – click for more)
? 19 months after the UK Soft Drinks Industry Levy (sugar tax) was implemented, we found an 8% relative reduction in obesity levels in 10/11 year old girls. Greatest reductions were found in girls from schools in the most deprived areas https://t.co/pYDHZZJrur
— Dr Nina Rogers (@Nina_Tr_Rogers) January 26, 2023
Position Paper | Enteral nutrition in preterm infants
30 Jan, 2023 | 00:54h | UTC
Toward nutrition improving outcome of critically ill patients: how to interpret recent feeding RCTs?
30 Jan, 2023 | 00:42h | UTC
RCT | Higher protein dosing did not improve outcomes in critically ill patients with high nutritional risk
27 Jan, 2023 | 12:24h | UTCThe effect of higher protein dosing in critically ill patients with high nutritional risk (EFFORT Protein): an international, multicentre, pragmatic, registry-based randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
Researchers aimed to test the hypothesis that a higher dose of protein provided to critically ill patients would improve clinical outcomes.
Here's what they found ? /4 https://t.co/C5JswTr82o
— The Lancet (@TheLancet) January 26, 2023