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Neurology

Cohort Study | Association between hearing aid use and all-cause and cause-specific dementia

17 Apr, 2023 | 13:07h | UTC

Association between hearing aid use and all-cause and cause-specific dementia: an analysis of the UK Biobank cohort – The Lancet Public Health

Commentaries: Preventing dementia through correcting hearing: huge progress but more to do – The Lancet Public Health

News Release: Hearing aids may protect against a higher risk of dementia associated with hearing loss, study suggests – Lancet

Related:

M-A | Association of hearing aids and cochlear implants with cognitive decline and dementia

Dementia and hearing-aid use: a two-way street – Age and Ageing

Association of Hearing Loss With Dementia – JAMA Network Open

 

Commentary on Twitter

 


Cohort Study | Major cardiovascular events after spontaneous intracerebral hemorrhage by hematoma location

12 Apr, 2023 | 13:13h | UTC

Major Cardiovascular Events After Spontaneous Intracerebral Hemorrhage by Hematoma Location – JAMA Network Open

Invited Commentary: Major Adverse Cardiovascular Events After Intracerebral Hemorrhage—It’s All About Location, Location, Location – JAMA Network Open

 


M-A | Ambient air pollution and clinical dementia

11 Apr, 2023 | 14:23h | UTC

Ambient air pollution and clinical dementia: systematic review and meta-analysis – The BMJ

Editorial: Air pollution and dementia – The BMJ

News Releases:

Air pollution may increase risk for dementia – Harvard T.H. Chan School of Public Health

Exposure to fine particle air pollution linked to heightened dementia risk – BMJ Newsroom

Commentary: Elevated dementia risk even when pollution is below EPA standards – The Harvard Gazette

 


AHA/ASA Scientific Statement | The neurovasculome: key roles in brain health and cognitive impairment

10 Apr, 2023 | 13:53h | UTC

The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association – Stroke

Top Things to Know: The Neurovasculome: Roles in brain health and cognitive impairment – American Heart Association

News Release: Blood vessels – not just brain cells – can affect brain health, new report finds – American Heart Association

Commentary: The Brain Vasculome. What Is It and What Does It Do? – American Heart Association

 

Commentary on Twitter

 


ESO expedited recommendation on tenecteplase for acute ischemic stroke

10 Apr, 2023 | 13:44h | UTC

European Stroke Organisation (ESO) expedited recommendation on tenecteplase for acute ischaemic stroke – European Stroke Journal

Related:

RCT | Tenecteplase noninferior to alteplase in acute ischemic cerebrovascular events

Tenecteplase vs. alteplase for treatment of acute ischemic stroke: A systematic review and meta-analysis of randomized trials – Frontiers in Neurology

RCT: A single immediate dose of intravenous tenecteplase is noninferior to alteplase for the treatment of patients with acute ischemic stroke.

RCT: Tenecteplase vs. alteplase for the management of acute ischemic stroke.

Randomized Controlled Trial: Tenecteplase vs Alteplase before Thrombectomy for Ischemic Stroke

 


Position Statement | Neuroprognostication in the post cardiac arrest patient

10 Apr, 2023 | 13:46h | UTC

Neuroprognostication in the Post Cardiac Arrest Patient: A Canadian Cardiovascular Society Position Statement – Canadian Journal of Cardiology

Related: Guidelines for Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest – Neurocritical Care

 


Cohort Study | Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care

10 Apr, 2023 | 13:38h | UTC

Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study – Intensive Care Medicine (free for a limited period)

 

Commentary on Twitter

 


RCT | Safety and efficacy of Pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy

6 Apr, 2023 | 13:08h | UTC

Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

Commentary: Pitolisant Improves Pediatric Narcolepsy Symptoms Regardless of Cataplexy in Phase 3 Study – Neurology Live

 


Cohort Study | Multimodal prediction of favorable outcome after cardiac arrest

6 Apr, 2023 | 13:01h | UTC

Multimodal Prediction of Favorable Outcome After Cardiac Arrest: A Cohort Study – Critical Care Medicine

 


RCT | Endovascular treatment vs. no treatment after 6-24h in ischemic stroke patients with collateral flow on CT angiography

5 Apr, 2023 | 13:38h | UTC

Endovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 


Cohort study | Younger stroke survivors show elevated cancer risk for up to 8 years

4 Apr, 2023 | 13:46h | UTC

Summary: In this cohort study, 390,398 patients aged 15 years or older in the Netherlands, without a history of cancer and with a first-ever ischemic stroke or intracerebral hemorrhage (ICH), were analyzed between January 1, 1998, and January 1, 2019. The primary outcome was the cumulative incidence of first-ever cancer after the index stroke, stratified by stroke subtype, age, and sex, compared with age-, sex-, and calendar year-matched peers from the general population.

The findings revealed that, in the first year after a stroke, patients aged 15 to 49 years had a 3- to 5-fold increased risk of cancer compared to individuals without a stroke. In contrast, the risk was only slightly elevated for patients aged 50 years or older. The cancer risk remained elevated for up to 8 years after an ischemic stroke and 6 years after an ICH in the younger age group, with the highest risks observed for lung cancer, gastrointestinal cancer, and hematologic cancer.

The findings may be confounded by shared risk factors, such as smoking. Alternatively, the increased cancer risk may have a causal mechanism between cancer and stroke, possibly related to the hypercoagulable state induced by cancer. However, the study design does not allow for conclusions about causal mechanisms, and the researchers called for further studies investigating the usefulness of cancer screening after a stroke.

Article: Association of Stroke at Young Age With New Cancer in the Years After Stroke Among Patients in the Netherlands – JAMA Network Open

 


RCT | Comparable results in endovascular therapy using general anesthesia vs. procedural sedation for stroke treatment

4 Apr, 2023 | 13:45h | UTC

Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke: The AMETIS Randomized Clinical Trial – JAMA Neurology (free for a limited period)

See also: Visual Abstract

Related: M-A | General Anesthesia vs. to Non-GA in endovascular thrombectomy for ischemic stroke

 


RCT | Memantine outperforms placebo for hair-pulling and skin-picking behaviors

4 Apr, 2023 | 13:40h | UTC

Double-Blind Placebo-Controlled Study of Memantine in Trichotillomania and Skin-Picking Disorder – American Journal of Psychiatry (link to abstract – $ for full-text)

News release: New research points to drug option for hair-pulling, skin-picking disorders – University of Chicago

Commentary: Memantine May Reduce Symptoms of Hair-Pulling, Skin-Picking Disorder – Psychiatric News Alert

 


Applying AI to MRI | A promising approach for detecting severe mental illness risk

4 Apr, 2023 | 13:25h | UTC

Detecting individuals with severe mental illness using artificial intelligence applied to magnetic resonance imaging – eBioMedicine

 


Postoperative delirium’s linked to long-term cognitive decline in elderly patients

3 Apr, 2023 | 13:20h | UTC

Postoperative Delirium’s linked to Long-term Cognitive Decline in Elderly Patients – JAMA Internal Medicine (link to abstract – $ for full-text)

News Release: Developing postoperative delirium associated with a faster rate of cognitive decline, says study – EurekAlert

Commentary: Postoperative Delirium Associated With Accelerated Cognitive Decline, Study Finds – Psychiatric News Alert

 

Commentary on Twitter

 


SR | Etiologies of vertigo in the elderly

31 Mar, 2023 | 13:38h | UTC

Vertigo in the Elderly: A Systematic Literature Review – Journal of Clinical Medicine

 


RCT | Zavegepant 10 mg nasal spray vs. placebo for the acute treatment of migraine

31 Mar, 2023 | 13:24h | UTC

Safety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial – The Lancet Neurology (link to abstract – $ for full-text)

 


2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

30 Mar, 2023 | 14:14h | UTC

Vitamin D supplementation and cognition—Results from analyses of the D-Health trial – Journal of the American Geriatrics Society (link to abstract – $ for full-text)

Original Study: RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Related:

Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

Research: Circulating vitamin D concentration and risk of seven cancers

Research: Vitamin D and risk of total and site specific cancers

 


Review | Insomnia diagnosis and treatment across the lifespan

30 Mar, 2023 | 13:36h | UTC

Insomnia diagnosis and treatment across the lifespan – Journal of Family Practice

 


Review | Cerebrovascular manifestations of SARS-CoV-2

29 Mar, 2023 | 13:29h | UTC

Cerebrovascular Manifestations of SARS-CoV-2: A Comprehensive Review – Current Treatment Options in Neurology

 


Brief Review | Long-term outcomes of intensive care unit delirium

27 Mar, 2023 | 13:09h | UTC

Long-term outcomes of intensive care unit delirium – Intensive Care Medicine

 

Commentary on Twitter

 


Guidelines for neuroprognostication in comatose adult survivors of cardiac arrest

27 Mar, 2023 | 12:54h | UTC

Guidelines for Neuroprognostication in Comatose Adult Survivors of Cardiac Arrest – Neurocritical Care

 


Guidelines for neuroprognostication in adults with Guillain-Barré Syndrome

27 Mar, 2023 | 12:52h | UTC

Guidelines for Neuroprognostication in Adults with Guillain–Barré Syndrome – Neurocritical Care

 


Cohort Study | Functional recovery, symptoms, and quality of life 1 to 5 years after traumatic brain injury

24 Mar, 2023 | 12:52h | UTC

Functional Recovery, Symptoms, and Quality of Life 1 to 5 Years After Traumatic Brain Injury – JAMA Network Open

 


RCT | Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy

23 Mar, 2023 | 12:44h | UTC

Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

 


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