Neurology
Cohort Study | Association between hearing aid use and all-cause and cause-specific dementia
17 Apr, 2023 | 13:07h | UTCCommentaries: Preventing dementia through correcting hearing: huge progress but more to do – The Lancet Public Health
News Release: Hearing aids may protect against a higher risk of dementia associated with hearing loss, study suggests – Lancet
Related:
M-A | Association of hearing aids and cochlear implants with cognitive decline and dementia
Dementia and hearing-aid use: a two-way street – Age and Ageing
Association of Hearing Loss With Dementia – JAMA Network Open
Commentary on Twitter
NEW—Hearing aids may protect against a higher risk of #dementia associated with hearing loss, a @TheLancetPH study suggests.https://t.co/Yliq2wT7SR pic.twitter.com/v3iuTuHYVI
— The Lancet (@TheLancet) April 13, 2023
Cohort Study | Major cardiovascular events after spontaneous intracerebral hemorrhage by hematoma location
12 Apr, 2023 | 13:13h | UTCInvited Commentary: Major Adverse Cardiovascular Events After Intracerebral Hemorrhage—It’s All About Location, Location, Location – JAMA Network Open
M-A | Ambient air pollution and clinical dementia
11 Apr, 2023 | 14:23h | UTCAmbient air pollution and clinical dementia: systematic review and meta-analysis – The BMJ
Editorial: Air pollution and dementia – The BMJ
News Releases:
Air pollution may increase risk for dementia – Harvard T.H. Chan School of Public Health
Exposure to fine particle air pollution linked to heightened dementia risk – BMJ Newsroom
Commentary: Elevated dementia risk even when pollution is below EPA standards – The Harvard Gazette
AHA/ASA Scientific Statement | The neurovasculome: key roles in brain health and cognitive impairment
10 Apr, 2023 | 13:53h | UTCTop Things to Know: The Neurovasculome: Roles in brain health and cognitive impairment – American Heart Association
News Release: Blood vessels – not just brain cells – can affect brain health, new report finds – American Heart Association
Commentary: The Brain Vasculome. What Is It and What Does It Do? – American Heart Association
Commentary on Twitter
The Neurovasculome: Key Roles in Brain Health and Cognitive Impairment: A Scientific Statement From the American Heart Association/American Stroke Association @American_Heart @American_Stroke @AHAScience @VCI_EricSmith @SusanneVanVeluwhttps://t.co/SrXuZS7tep pic.twitter.com/WRRR3kVQVQ
— Stroke AHA/ASA (@StrokeAHA_ASA) April 3, 2023
ESO expedited recommendation on tenecteplase for acute ischemic stroke
10 Apr, 2023 | 13:44h | UTCRelated:
RCT | Tenecteplase noninferior to alteplase in acute ischemic cerebrovascular events
RCT: Tenecteplase vs. alteplase for the management of acute ischemic stroke.
Randomized Controlled Trial: Tenecteplase vs Alteplase before Thrombectomy for Ischemic Stroke
Position Statement | Neuroprognostication in the post cardiac arrest patient
10 Apr, 2023 | 13:46h | UTC
Cohort Study | Clinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care
10 Apr, 2023 | 13:38h | UTCClinical features, etiologies, and outcomes in adult patients with meningoencephalitis requiring intensive care (EURECA): an international prospective multicenter cohort study – Intensive Care Medicine (free for a limited period)
Commentary on Twitter
? Meningoencephalitis in adults requiring #ICU, EURECA study
➡️ poor outcomes at 3 months (moderate-to-severe disability or death) in ½ pts
➡️ older age, immunodepression, neurologic presentation nonmodifiable factors associated w poor outcome.#FOAMcc
?️ https://t.co/AR3w8x0Hiy pic.twitter.com/ChoucOnP8B— Intensive Care Medicine (@yourICM) April 7, 2023
RCT | Safety and efficacy of Pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy
6 Apr, 2023 | 13:08h | UTCSafety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)
Commentary: Pitolisant Improves Pediatric Narcolepsy Symptoms Regardless of Cataplexy in Phase 3 Study – Neurology Live
Cohort Study | Multimodal prediction of favorable outcome after cardiac arrest
6 Apr, 2023 | 13:01h | UTC
RCT | Endovascular treatment vs. no treatment after 6-24h in ischemic stroke patients with collateral flow on CT angiography
5 Apr, 2023 | 13:38h | UTCEndovascular treatment versus no endovascular treatment after 6–24 h in patients with ischaemic stroke and collateral flow on CT angiography (MR CLEAN-LATE) in the Netherlands: a multicentre, open-label, blinded-endpoint, randomised, controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Cohort study | Younger stroke survivors show elevated cancer risk for up to 8 years
4 Apr, 2023 | 13:46h | UTCSummary: In this cohort study, 390,398 patients aged 15 years or older in the Netherlands, without a history of cancer and with a first-ever ischemic stroke or intracerebral hemorrhage (ICH), were analyzed between January 1, 1998, and January 1, 2019. The primary outcome was the cumulative incidence of first-ever cancer after the index stroke, stratified by stroke subtype, age, and sex, compared with age-, sex-, and calendar year-matched peers from the general population.
The findings revealed that, in the first year after a stroke, patients aged 15 to 49 years had a 3- to 5-fold increased risk of cancer compared to individuals without a stroke. In contrast, the risk was only slightly elevated for patients aged 50 years or older. The cancer risk remained elevated for up to 8 years after an ischemic stroke and 6 years after an ICH in the younger age group, with the highest risks observed for lung cancer, gastrointestinal cancer, and hematologic cancer.
The findings may be confounded by shared risk factors, such as smoking. Alternatively, the increased cancer risk may have a causal mechanism between cancer and stroke, possibly related to the hypercoagulable state induced by cancer. However, the study design does not allow for conclusions about causal mechanisms, and the researchers called for further studies investigating the usefulness of cancer screening after a stroke.
RCT | Comparable results in endovascular therapy using general anesthesia vs. procedural sedation for stroke treatment
4 Apr, 2023 | 13:45h | UTCOutcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Patients With Acute Ischemic Stroke: The AMETIS Randomized Clinical Trial – JAMA Neurology (free for a limited period)
See also: Visual Abstract
Related: M-A | General Anesthesia vs. to Non-GA in endovascular thrombectomy for ischemic stroke
RCT | Memantine outperforms placebo for hair-pulling and skin-picking behaviors
4 Apr, 2023 | 13:40h | UTCDouble-Blind Placebo-Controlled Study of Memantine in Trichotillomania and Skin-Picking Disorder – American Journal of Psychiatry (link to abstract – $ for full-text)
News release: New research points to drug option for hair-pulling, skin-picking disorders – University of Chicago
Commentary: Memantine May Reduce Symptoms of Hair-Pulling, Skin-Picking Disorder – Psychiatric News Alert
Applying AI to MRI | A promising approach for detecting severe mental illness risk
4 Apr, 2023 | 13:25h | UTC
Postoperative delirium’s linked to long-term cognitive decline in elderly patients
3 Apr, 2023 | 13:20h | UTCPostoperative Delirium’s linked to Long-term Cognitive Decline in Elderly Patients – JAMA Internal Medicine (link to abstract – $ for full-text)
News Release: Developing postoperative delirium associated with a faster rate of cognitive decline, says study – EurekAlert
Commentary: Postoperative Delirium Associated With Accelerated Cognitive Decline, Study Finds – Psychiatric News Alert
Commentary on Twitter
Delirium associated with accelerated cognitive decline that continued for 72 months following the index delirium episode; it's uncertain if delirium causes cognitive decline or if pts with preclinical brain disease are more likely to develop delirium. https://t.co/ADz7yxEZiP
— JAMA Internal Medicine (@JAMAInternalMed) March 20, 2023
SR | Etiologies of vertigo in the elderly
31 Mar, 2023 | 13:38h | UTCVertigo in the Elderly: A Systematic Literature Review – Journal of Clinical Medicine
RCT | Zavegepant 10 mg nasal spray vs. placebo for the acute treatment of migraine
31 Mar, 2023 | 13:24h | UTCSafety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial – The Lancet Neurology (link to abstract – $ for full-text)
2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults
30 Mar, 2023 | 14:14h | UTCVitamin D supplementation and cognition—Results from analyses of the D-Health trial – Journal of the American Geriatrics Society (link to abstract – $ for full-text)
Related:
Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease
Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention
Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases
Research: Circulating vitamin D concentration and risk of seven cancers
Research: Vitamin D and risk of total and site specific cancers
Review | Insomnia diagnosis and treatment across the lifespan
30 Mar, 2023 | 13:36h | UTCInsomnia diagnosis and treatment across the lifespan – Journal of Family Practice
Review | Cerebrovascular manifestations of SARS-CoV-2
29 Mar, 2023 | 13:29h | UTC
Brief Review | Long-term outcomes of intensive care unit delirium
27 Mar, 2023 | 13:09h | UTCLong-term outcomes of intensive care unit delirium – Intensive Care Medicine
Commentary on Twitter
#ICU delirium
? well described short-term effects: ⬆️ hospital mortality, MV duration, ICU/hospital LoS
? more recent findings related to long-term outcomes (≥ 6 months post-ICU)
How to mitigate this serious acute BI & its long-term burden? #FOAMcc
?️ https://t.co/kg5TIOmVHm pic.twitter.com/Hnbc1ISKnI— Intensive Care Medicine (@yourICM) March 25, 2023
Guidelines for neuroprognostication in comatose adult survivors of cardiac arrest
27 Mar, 2023 | 12:54h | UTC
Guidelines for neuroprognostication in adults with Guillain-Barré Syndrome
27 Mar, 2023 | 12:52h | UTCGuidelines for Neuroprognostication in Adults with Guillain–Barré Syndrome – Neurocritical Care
Cohort Study | Functional recovery, symptoms, and quality of life 1 to 5 years after traumatic brain injury
24 Mar, 2023 | 12:52h | UTC
RCT | Safety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy
23 Mar, 2023 | 12:44h | UTCSafety and efficacy of pitolisant in children aged 6 years or older with narcolepsy with or without cataplexy: a double-blind, randomised, placebo-controlled trial – The Lancet Neurology (link to abstract – $ for full-text)