Neurology
Scientists tie third clinical trial death to experimental Alzheimer’s drug
9 Jan, 2023 | 14:47h | UTCScientists tie third clinical trial death to experimental Alzheimer’s drug – Science
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
M-A | Vestibular suppressants do not reduce symptoms in patients with benign paroxysmal positional vertigo.
16 Dec, 2022 | 13:18h | UTCVestibular suppressants for benign paroxysmal positional vertigo: A systematic review and meta-analysis of randomized controlled trials – Academic Emergency Medicine (link to abstract – $ for full-text)
RCT | Mindfulness training and exercise did not improve cognitive function in older adults.
15 Dec, 2022 | 13:48h | UTCEffects of Mindfulness Training and Exercise on Cognitive Function in Older Adults: A Randomized Clinical Trial – JAMA (free for a limited period)
See also: Visual Abstract
News Release: Exercise, mindfulness don’t appear to boost cognitive function in older adults – Washington University School of Medicine
RCT | Safety and efficacy of continuous subcutaneous foslevodopa-foscarbidopa in patients with advanced Parkinson’s disease.
15 Dec, 2022 | 13:38h | UTCSafety and efficacy of continuous subcutaneous foslevodopa-foscarbidopa in patients with advanced Parkinson’s disease: a randomised, double-blind, active-controlled, phase 3 trial – The Lancet Neurology (link to abstract – $ for full-text)
Commentary on Twitter
In a phase 3, randomised controlled trial, Michael Soileau and colleagues aimed to assess the safety and efficacy of a soluble formulation of levodopa and carbidopa in patients with advanced Parkinson's disease. Read the results at: https://t.co/9G8S01juSC pic.twitter.com/0SG0oTe8na
— The Lancet Neurology (@TheLancetNeuro) November 17, 2022
Review | Management of chronic migraine.
15 Dec, 2022 | 13:41h | UTCManagement of chronic migraine – The BMJ
Review | Management of psychiatric and cognitive complications in Parkinson’s disease.
15 Dec, 2022 | 13:39h | UTCManagement of psychiatric and cognitive complications in Parkinson’s disease – The BMJ
Pictorial Review | Nerve entrapment syndromes of the upper limb.
15 Dec, 2022 | 13:25h | UTCNerve entrapment syndromes of the upper limb: a pictorial review – Insights into Imaging
Cohort Study | Prenatal carbamazepine exposure and academic performance in adolescents.
13 Dec, 2022 | 14:22h | UTCPrenatal Carbamazepine Exposure and Academic Performance in Adolescents: A Population-Based Cohort Study – Neurology (link to abstract – $ for full-text)
Consensus Paper | Standardized treatment pathway algorithm for lumbar spinal stenosis.
13 Dec, 2022 | 14:25h | UTC
Case-control study | Association of psychosocial stress with risk of acute stroke.
12 Dec, 2022 | 12:30h | UTCAssociation of Psychosocial Stress With Risk of Acute Stroke – JAMA Network Open
Commentary: Increased Risk of Stroke Linked to Stress at Home, Work – Psychiatric News Alert
M-A | Evaluation of direct oral anticoagulant reversal agents in intracranial hemorrhage.
9 Dec, 2022 | 13:17h | UTC
Commentary on Twitter
Meta-analysis finds mostly successful DOAC reversal with 4F-PCC (77%), andexanet alfa (AA)(75%), and idarucizumab (82%) in patients with ICH. 4F-PCC and AA had comparable success in factor Xa inhibitor reversal, mortality, and thromboembolic outcomes. #OA https://t.co/aieJd9h5jo
— JAMA Network Open (@JAMANetworkOpen) November 4, 2022
Cohort Study | Comparative safety of antiseizure medication monotherapy in pregnancy for major malformations.
9 Dec, 2022 | 13:10h | UTCComparative safety of antiseizure medication monotherapy for major malformations – Annals of Neurology (link to abstract – $ for full-text)
Related:
Risks of 23 Specific Malformations Associated with Prenatal Exposure to 10 Antiepileptic Drugs
Research: Topiramate Use Early in Pregnancy and the Risk of Oral Clefts
Educational attainment of children born to mothers with epilepsy – Journal of Neurology, Neurosurgery, and Psychiatry (link to abstract – $ for full-text)
Acute ischemic stroke: recent advances in reperfusion treatment.
8 Dec, 2022 | 13:05h | UTCAcute ischaemic stroke: recent advances in reperfusion treatment – European Heart Journal
RCT | Iron chelation with Deferiprone fails to improve outcomes in Parkinson’s Disease.
6 Dec, 2022 | 13:46h | UTCTrial of Deferiprone in Parkinson’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Deferiprone Not Beneficial for Newly Diagnosed Parkinson Disease – HealthDay
Commentary on Twitter
Iron deposition in the substantia nigra has been implicated in Parkinson’s disease. Chelation with deferiprone reduced brain iron content but led to worse scores on scales of the movement disorder at 36 weeks. https://t.co/aXYCzAt2JM pic.twitter.com/Lw07VK5ZJX
— NEJM (@NEJM) December 3, 2022
Podcast | Parkinson’s Disease for primary care.
6 Dec, 2022 | 13:43h | UTC#370 Parkinson’s Disease for Primary Care with Dr. Albert Hung – The Curbsiders
RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
2 Dec, 2022 | 14:40h | UTCLecanemab in Early Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Heralded Alzheimer’s drug works — but safety concerns loom – Nature
Lecanemab and Alzheimer’s: More Data – Science
Alzheimer’s Drug is Hailed Amid Safety Concerns – Health Policy Watch
Related: Second death linked to potential antibody treatment for Alzheimer’s disease – Science
Commentary on Twitter
In a phase 3 trial, participants with early Alzheimer’s disease who received the monoclonal antibody lecanemab had less decline on measures of cognitive function at 18 months than those who received placebo. https://t.co/NjEloWVk1V pic.twitter.com/n33yjV9117
— NEJM (@NEJM) November 30, 2022
Cross-sectional study | Overweight women may be at increased risk of long Covid.
2 Dec, 2022 | 14:33h | UTCCommentaries:
Overweight women may be at highest risk of long COVID – new research – The Conversation
RCT | Effect of irrigation fluid temperature on recurrence in the evacuation of chronic subdural hematoma.
30 Nov, 2022 | 13:45h | UTCNews Release: Warmer brain-irrigation fluid in surgery more efficacious – University of Gothenburg
Commentary on Twitter
Study explored how a physical property, such as irrigation fluid temperature, can affect outcomes of neurosurgery for chronic subdural hematoma evacuation. https://t.co/ZHciO3VaTP #Research
— JAMA Neurology (@JAMANeuro) November 22, 2022
Review | Safety and management of implanted epilepsy devices for imaging and surgery.
27 Nov, 2022 | 22:03h | UTC
Brief Review | Ischemic stroke in patients with malignancy.
27 Nov, 2022 | 22:01h | UTCIschemic Stroke in Patients With Malignancy – Mayo Clinic Proceedings
Brief Review | Extubation in neurocritical care patients: lesson learned.
25 Nov, 2022 | 12:31h | UTCExtubation in neurocritical care patients: lesson learned – Intensive Care Medicine
Commentary on Twitter
Extubation in neuro #ICU
? assess neuro function stability
? perform if minimal level of consciousness, upper airway secure, negative fluid balance
? elaborate multi-disciplinary local protocols, selecting criteria according to resources/expertise
?️ https://t.co/5tvpdkHcar pic.twitter.com/DAdCKwkHng— Intensive Care Medicine (@yourICM) October 17, 2022
Cohort Study | Association of obesity with disease outcomes in multiple sclerosis.
25 Nov, 2022 | 12:24h | UTCNews Release: Obesity at MS diagnosis linked to higher levels of disability – BMJ Newsroom
SR | Surgical decompression for malignant cerebral edema after ischemic stroke.
24 Nov, 2022 | 13:25h | UTCSurgical decompression for malignant cerebral oedema after ischaemic stroke – Cochrane Library
Summary: Surgical decompression for people with severe brain swelling after stroke – Cochrane Library
RCT | Simvastatin is ineffective as a disease-modifying treatment for patients with Parkinson’s Disease.
23 Nov, 2022 | 13:42h | UTCCommentary: Simvastatin Ineffective as Disease-Modifying Therapy for Intermediate Parkinson Disease – AJMC
Commentary on Twitter
In a randomized clinical trial, #simvastatin was futile as a disease-modifying therapy in UK patients with moderate #ParkinsonDisease. https://t.co/etNsG7b3fI @Pen_CTU @NIHRSW @CureParkinsonsT @UHP_NHS @PlymUni
— JAMA Neurology (@JAMANeuro) November 1, 2022
M-A | Use of CT of the head in patients with acute atraumatic altered mental status.
22 Nov, 2022 | 13:38h | UTC
Commentary on Twitter
Meta-analysis: 94% of patients with atraumatic altered mental status received a noncontrast CT head, with an average yield of 11% which varied by setting: 18% in ED patients, 12% of ICU patients, and 3% of general inpatients had positive findings on CT. https://t.co/yHWj6uSwTM
— JAMA Network Open (@JAMANetworkOpen) November 18, 2022