Review: Evaluation and management of sport-related concussions in adolescent athletes

22Aug
2017

Study: Uric acid and incident dementia

22Aug
2017

Free Online Course: Advanced Neurobiology I

21Aug
2017

Coma After Acute Head Injury

17Aug
2017

Benefits and safety of gabapentinoids in chronic low back pain

16Aug
2017

Guidelines for diagnosis, treatment and follow-up of patients with leptomeningeal metastasis from solid tumours

16Aug
2017

Epilepsy ‘Not a Rare Condition’

16Aug
2017

Risk traumatic brain injuries associated with antidepressant use among patients with Alzheimer’s disease

15Aug
2017

Risk Factors for Post-stroke Depression

15Aug
2017

Management of urinary tract infections in patients with neurogenic bladder

15Aug
2017

Car crashes in older adult drivers using Zolpidem

15Aug
2017

Neurologic Complications Associated With the Zika Virus

15Aug
2017

Day-to-Day Blood Pressure Variability and Risk of Dementia

14Aug
2017

Risk of Stroke With Various Types of Menopausal Hormone Therapies

14Aug
2017

Risk of Stroke With Various Types of Menopausal Hormone Therapies: A National Cohort Study – Stroke (link to abstract – $ for full-text)

Source: EvidenceAlerts

This large cohort confirms an increased stroke risk with oral hormone therapies, but suggests no increased risk of stroke with transdermal or vaginal estrogen application.

 

Exenatide for Parkinson’s disease?

11Aug
2017

Lifestyle Risk Factors Increase the Risk of Hospitalization for Sciatica

11Aug
2017

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients

11Aug
2017

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients: A Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Better outcomes seen in patients who received IV thrombolysis before thrombectomy – ACP Hospitalist (free)

“The results support current guideline recommendations to give intravenous thrombolysis to eligible patients even if they are being considered for mechanical thrombectomy, according to the meta-analysis authors” (from ACP)

 

Intracranial Arterial Dolichoectasia

11Aug
2017

Left atrial appendage occlusion for stroke prevention in patients with atrial fibrillation

11Aug
2017

What do hypnotics cost hospitals and healthcare?

10Aug
2017

What do hypnotics cost hospitals and healthcare? – F1000 Research (free)

Source: Hospital Medicine Virtual Journal Club

“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.

 

Effect of marijuana use on cardiovascular and cerebrovascular mortality

10Aug
2017

Gadolinium deposition in the brain: summary of evidence and recommendations

9Aug
2017

Guideline: stroke prevention in atrial fibrillation

7Aug
2017

Telerehabilitation: Review of the State-of-the-Art and Areas of Application

5Aug
2017

Coagulopathy in the Setting of Mild Traumatic Brain Injury

5Aug
2017

Have Smartphones Destroyed a Generation?

4Aug
2017

Have Smartphones Destroyed a Generation? – The Atlantic (free)

Long read… very interesting.

 

Mechanical clot removal for stroke reduces disability at two years

3Aug
2017

Mechanical clot removal for stroke reduces disability at two years – NIHR Signal (free)

“Mechanical thrombectomy within six hours of stroke onset provides a sustained reduction of disability for patients” (RT @NIHR_DC see Tweet)

 

Prescribing regular drugs to prevent febrile convulsions risks more harm than benefit

3Aug
2017

Prescribing regular drugs to prevent febrile convulsions risks more harm than benefit – NIHR Signal (free)

Original article: Prophylactic drug management for febrile seizures in children – Cochrane Library (link to summary – $ for full-text)

“Benefits of anti-epileptic medication for children who’ve had a convulsion while feverish, do not outweigh harms” (RT @NIHR_DC see Tweet)

 

A soft robotic exosuit improves walking in patients after stroke

3Aug
2017

Oral fluoroquinolones and risk of secondary pseudotumor cerebri syndrome

3Aug
2017

Quitting statins after stroke may raise risk of another stroke

3Aug
2017

Targeted Temperature Management for 48 vs 24 Hours and Neurologic Outcome After Out-of-Hospital Cardiac Arrest

1Aug
2017

Diabetes mellitus and stroke: A clinical update

1Aug
2017

Treatment Outcomes for Patients with Failed Back Surgery

1Aug
2017

Intensive speech therapy helps stroke survivors with persistent communication difficulties

28Jul
2017

Surgical Informed Consent Process in Neurosurgery

28Jul
2017

Social Interaction Improves Quality Of Life For People With Dementia

27Jul
2017

Clinicopathological Evaluation of Chronic Traumatic Encephalopathy in Players of American Football

27Jul
2017

Early Orthostatic Hypotension and Orthostatic Intolerance

25Jul
2017

Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults – JAMA Internal Medicine (free)

Invited commentary: Early Orthostatic Hypotension and Orthostatic Intolerance—More Than an Observation or Annoyance (free)

Practice Changing – Orthostatic hypotension within 1 min of standing (rather than at 3 minutes) has greater relation to falls, fracture, syncope, motor vehicle crash, and mortality.

 

Parkinson Disease and Melanoma

25Jul
2017

Cardiocerebral and cardiopulmonary resuscitation – 2017 update

25Jul
2017

Early vs Later Orthostatic Hypotension Assessment Times

25Jul
2017

Association of History of Dizziness and Long-term Adverse Outcomes With Early vs Later Orthostatic Hypotension Assessment Times in Middle-aged Adults – JAMA Internal Medicine (free)

Invited commentary: Early Orthostatic Hypotension and Orthostatic Intolerance—More Than an Observation or Annoyance (free)

Practice Changing – Orthostatic hypotension within 1 min of standing (rather than at 3 minutes) has greater relation to falls, fracture, syncope, motor vehicle crash, and mortality.

 

Long-term morbidity and mortality in patients without early complications after stroke or transient ischemic attack

25Jul
2017

Is cyclobenzaprine useful for pain?

25Jul
2017

Is cyclobenzaprine useful for pain? – Therapeutics Initiative (free)

“…cyclobenzaprine is a long-acting sedative, not a muscle relaxant, and questioning whether any potential benefits are worth the side effects”. (from TI Newsletter). “If prescribed, a dose of 5 mg at bedtime should be tried first.  Evidence suggests titration based on response and tolerability to a maximum dose of 15 mg/day, for no longer than one week”.

 

Amyloid PET for Mild Cognitive Impairment Diagnosis

25Jul
2017

Amyloid PET a ‘Game Changer’ for MCI Diagnosis – Medscape (free registration required)

Coverage from the Alzheimer’s Association International Conference (AAIC) 2017

 

Effectiveness of Lateral Decubitus Position for Preventing Post-Dural Puncture Headache

23Jul
2017

Effectiveness of Lateral Decubitus Position for Preventing Post-Dural Puncture Headache: A Meta-Analysis – Pain Physician (free PDF)

Source: Hospital Medicine Virtual Journal Club (free resource to find articles of interest)

Evidence suggests lateral decubitus position is associated with reduced incidence of post-dural puncture headache.

 

Electrical stimulation can help people who are too weak to exercise

23Jul
2017

Cognitive Impairment and Heart Failure

23Jul
2017

The Evolving Story of Overlapping Surgery

23Jul
2017

Viewpoint: The Evolving Story of Overlapping Surgery – JAMA (free) (RT @pash22 see Tweet)

Commentary: 3 steps to restore patient trust in overlapping surgeries – FierceHealthcare (free)

This interesting viewpoint discusses the practice of scheduling overlapping surgeries, in which a qualified practitioner finishes noncritical parts of the first operation while the primary surgeon moves to the next surgery.

 

Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons

22Jul
2017

More Millennials Are Having Strokes

22Jul
2017

Short review: Subarachnoid Hemorrhage

21Jul
2017

Cerebellar Dysfunction in Multiple Sclerosis

21Jul
2017

NICE Guideline: Parkinson’s disease in adults

21Jul
2017

Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin

21Jul
2017

Antiplatelet Regimen for Patients With Breakthrough Strokes While on Aspirin: A Systematic Review and Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Adjusting Antiplatelet Regimen Could Decrease Risk For Stroke Patients on Aspirin Monotherapy – American College of Cardiology, Latest in Cardiology (free)

Meta-analysis of cohort studies: in patients who experienced an ischemic stroke or transient ischemic attack while on aspirin monotherapy, the addition of or a switch to another antiplatelet agent, versus aspirin monotherapy, was associated with a 32 percent reduction in the risk of major adverse cardiovascular events (HR 0.68; 0.54–0.85) and 30 percent reduction in recurrent strokes (HR, 0.70; 0.54–0.92). Additional randomized trials would better clarify the best antiplatet regimen for these patients.

 

Dementia prevention, intervention, and care

21Jul
2017

New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

20Jul
2017

Guidelines for diagnosis, prevention and management of central nervous system involvement in diffuse large B-cell lymphoma

18Jul
2017

Concise review: Amyotrophic Lateral Sclerosis

18Jul
2017

Emergency Management of Pediatric Seizures

18Jul
2017

Inborn Errors of Metabolism and Epilepsy: Current Understanding, Diagnosis, and Treatment Approaches

18Jul
2017

Multiple Sclerosis: Immunopathology and Treatment Update

18Jul
2017

Systematic review: Antiepileptic drug monotherapy

17Jul
2017

Differential diagnosis of neuromyelitis optica spectrum disorders

16Jul
2017

Study: No effect of commercial cognitive training on cognitive function

13Jul
2017

Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke

12Jul
2017

Blood pressure and in-hospital outcomes in patients presenting with ischaemic stroke – European Heart Journal (link to abstract – $ for full-text)

Commentary: Blood Pressure and Outcomes After Ischemic Stroke – American College of Cardiology, Latest in Cardiology (free)

Related article: Editorial: Blood Pressure in Acute Stroke Still No Answer for Management – Stroke (free PDF)

Observational analysis of over 300.000 patients suggests a J-shaped, or U-shaped relationships between BP and outcomes (both lower and higher BP levels detrimental). Among patients submitted to thrombolytic therapy, there were fewer complications with lower blood pressure.

 

Antidepressant Switching vs Augmentation in Resistent Depression?

12Jul
2017

Effect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentaries: Study Compares Switching Meds vs an Additional Med for Patients Unresponsive to an Antidepressant – The Jama Network (free) AND For Treatment-Resistant Depression, Add an Antipsychotic or Switch Antidepressants? – Physician’s First Watch (free)

Augmentation with aripiprazole led to a modestly increased likelihood of remission, but with more adverse effects. “Given the small effect size and adverse effects associated with aripiprazole, further analysis including cost-effectiveness is needed to understand the net utility of this approach”.

 

Positive airway pressure doesn’t reduce cardiovascular events and death in adults with sleep apnea

12Jul
2017

Association of Positive Airway Pressure With Cardiovascular Events and Death in Adults With Sleep Apnea: A Systematic Review and Meta-analysis – JAMA (link to abstract – $ for full-text)

Commentaries: More Doubt Cast on CPAP for Reducing CVD Risk in Sleep Apnea Patients – MedPage Today (free registration required) AND Positive airway pressure doesn’t reduce heart risk with sleep apnea – Reuters (free)

“PAP for obstructive sleep apnea improves quality of life but not CV events or BP with up to 5 years of follow up” (RT @AnilMakam see Tweet)

 

Effect of Depth and Duration of Cooling on Death or Disability at Age 18 Months Among Neonates With Hypoxic-Ischemic Encephalopathy

11Jul
2017

Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia

11Jul
2017

Gabapentin for chronic neuropathic pain in adults

9Jul
2017

Cochrane Review: Gabapentin for chronic neuropathic pain in adults – Cochrane Library (link to abstract – $ for full-text)

Commentary: Analgesic Effects of Gabapentin Assessed in Chronic Neuropathic Pain – MPR (free)

“Gabapentin at doses of 1800 mg to 3600 mg daily (1200 mg to 3600 mg gabapentin encarbil) can provide good levels of pain relief to some people with postherpetic neuralgia and peripheral diabetic neuropathy”.

 

Association of Playing High School Football With Cognition and Mental Health Later in Life

8Jul
2017

Rivastigmine reviewed: doubts about dementia drug

7Jul
2017

Rivastigmine reviewed: doubts about dementia drug – Evidently Cochrane (free)

Related review: Rivastigmine for people with Alzheimer’s disease – Cochrane Library (link to abstract – $ for full-text)

“”Sadly, “small” and “of uncertain clinical importance” are the words chosen by the Cochrane reviewers to describe…” (RT @CochraneUK see Tweet)

 

Revised diagnostic criteria for neurocysticercosis

7Jul
2017

Sarcopenia: Neurological Point of View

7Jul
2017

Autism spectrum disorder and epileptic encephalopathy: common causes, many questions

7Jul
2017

Medication-Induced Tardive Dyskinesia

7Jul
2017

Functional neuroimaging and chorea

7Jul
2017

Surgical clipping or endovascular coiling for unruptured intracranial aneurysms

7Jul
2017

Herpes Zoster Increases the Risk of Stroke and Myocardial Infarction

5Jul
2017

Quality of Life in Dementia

4Jul
2017

Quality of Life in Dementia – The AMA Journal of Ethics (free)

“What can clinicians do to normalize the experience of dementia? Our new issue explores the ethics of dementia care” (RT @JournalofEthics see Tweet)

 

Rest tremor revisited: Parkinson’s disease and other disorders

3Jul
2017

Depression following traumatic brain injury: prevalence, impact, and management challenges

3Jul
2017

Toxins in Brain! Magnetic Resonance (MR) Imaging of Toxic Leukoencephalopathy

3Jul
2017

Perioperative Management of Neurological Conditions

3Jul
2017

Amantadine for Levodopa-Induced Dyskinesia in Parkinson Disease

3Jul
2017

Delirium Prevention Strategies for Elderly Adults with Hip Fracture

30Jun
2017

Acupuncture shown to have benefits for treatment of some chronic pain

27Jun
2017

Genetic sequencing of spinal fluid for diagnosing brain infections?

25Jun
2017

Brain-Invading Tapeworm That Eluded Doctors Spotted by New DNA Test – Scientific American (free)

“Genetic sequencing of spinal fluid hailed as an advance over standard procedures for diagnosing brain infections”

 

Targeted temperature management in the ICU

23Jun
2017

Spasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers

23Jun
2017

Spasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers – Medscape (free registration required)

Unpublished results, presented at the 13th World Congress of Biological Psychiatry, suggesting baclofen is an effective alternative for high-risk alcohol consumption.

 

Management of Brain Arteriovenous Malformations

23Jun
2017

Head Positioning in Acute Stroke

23Jun
2017

Preventing Cognitive Decline and Dementia

23Jun
2017

Co-morbid OSA and insomnia increases depression prevalence and severity in men

23Jun
2017

Performance Improvement: Phenytoin Toxicity

22Jun
2017

Performance Improvement: Phenytoin Toxicity – JAMA (free)

Interesting case of medication error and prevention of subsequent adverse events (RT @JAMA_current see Tweet)

 

Predicting cognitive deficits in people with Parkinson’s disease

21Jun
2017

Can Zika infection attack the brains of newborns?

21Jun
2017

Review: Differentiating lower motor neuron syndromes

20Jun
2017

Antiplatelet Therapy in Patients With Coronary Stents Undergoing Elective Noncardiac Surgery

20Jun
2017
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