Neurology

Guidelines for safe transfer of the brain‐injured patient: trauma and stroke, 2019 – Anaesthesia (free)

 

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Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Head-to-head comparison finds three anti-seizure drugs equally effective for severe form of epilepsy – NIH News Release (free)

 

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Podcast: Update in Sleep Medicine

27 Nov, 2019 | 08:08h | UTC

Bedside Optic Nerve Ultrasonography for Diagnosing Increased Intracranial Pressure: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Bedside optic nerve ultrasonography may be useful for measuring intracranial pressure – ACP Hospitalist (free) AND Optic Nerve Ultrasound May ID Increased Intracranial Pressure – Physician’s Briefing (free)

 

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A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Treat Stroke to Target Finds Lower Risk of CV Events With Lower LDL-C Levels – American College of Cardiology (free) AND Treat Stroke to Target – Treat Stroke to Target – American College of Cardiology (free) AND Lower Cholesterol Cuts CV Events: Treat Stroke to Target Trial – TCTMD (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Illiteracy, dementia risk, and cognitive trajectories among older adults with low education – Neurology (link to abstract – $ for full-text)

News Release: People who cannot read may be three times as likely to develop dementia – American Academy of Neurology (free)

“The independent effect of illiteracy on dementia risk may be through a lower range of cognitive function, which is closer to diagnostic thresholds for dementia than the range of literate participants.”

 


Therapeutic-induced hypertension in patients with noncardioembolic acute stroke – Neurology (link to abstract – $ for full-text)

 

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A management algorithm for patients with intracranial pressure monitoring: the Seattle International Severe Traumatic Brain Injury Consensus Conference (SIBICC) – Intensive Care Medicine (free)

 

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Neurodegenerative Disease Mortality among Former Professional Soccer Players – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Dementia in football: Ex-players three and a half times more likely to die of condition – BBC (free) AND Study shows more thinking problems in former pro soccer players – Reuters (free)

 

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Review: Pure Autonomic Failure

10 Oct, 2019 | 09:09h | UTC

Medical Management vs Mechanical Thrombectomy for Mild Strokes: An International Multicenter Study and Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Medical Therapy Vs Endovascular Therapy: Similar Outcomes for Mild Strokes – Neurology Today (free) AND Similar Benefits for Thrombectomy, Medical Management, in Mild Stroke – Medscape (free)

 

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Antiviral treatment for Bell’s palsy (idiopathic facial paralysis) – Cochrane Library (free)

Summary: Antiviral treatment for Bell’s palsy – Cochrane Library (free)

“The combination of antivirals and corticosteroids may have little or no effect on rates of incomplete recovery in comparison to corticosteroids alone”

 


Canadian Guideline for Parkinson Disease

10 Sep, 2019 | 01:52h | UTC

Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: ‘Silent’ strokes common after surgery, linked to cognitive decline – McMaster University (free) AND ‘Silent’ strokes after elective surgeries in older adults double their risk of later cognitive decline, study finds – The Globe and Mail (free)

 

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Long-term antithrombotic therapy and risk of intracranial haemorrhage from cerebral cavernous malformations: a population-based cohort study, systematic review, and meta-analysis – The Lancet Neurology (free)

Invited Commentary: Antithrombotics and bleeding risk: paradoxical findings (free)

 

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Podcast: Stroke and TIA Deconstructed

6 Aug, 2019 | 08:04h | UTC

NICE Guideline: Motor Neuron Disease

24 Jul, 2019 | 09:32h | UTC

Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis – Stroke (free)

Source: EvidenceAlerts

“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.

 


The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms – JAMA Neurology (free for a limited period)

Original Article: Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework – JAMA Neurology (free)

 

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How I manage intracranial hypertension – Critical Care (free)

 

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Preclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis? – JAMA Internal Medicine (free for a limited period)

 

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Quantity and quality of mental activities and the risk of incident mild cognitive impairment – Neurology (free PDF)

Commentary: Mentally stimulating activities linked to lower risk or delay of age-related memory loss – News Medical (free)

 

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Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data – The Lancet (link to abstract – $ for full-text)

“Patients with ischemic stroke 4·5–9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo. The rate of symptomatic intracerebral hemorrhage was higher with alteplase, but this increase did not negate the overall net benefit of thrombolysis.”

 

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Review: The Etiology of Bell’s Palsy

16 May, 2019 | 05:41h | UTC

“The Case of the Magician’s Sleight” – EMNerd (free)

See also: EXTEND Alteplase Shenanigans! – Emergency Medicine Literature of Note (free)

Original Study: Randomized Trial: Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke (link to abstract and commentary)

Related Cochrane Review: Thrombolysis for acute ischaemic stroke (free)

Related Review: Thrombolytics for stroke: The evidence – First10Em (free)

 

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State of the Art Review: Diagnosis and management of sensory polyneuropathy – The BMJ (free for a limited period)

 

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POEMS Syndrome: Clinical Update

9 May, 2019 | 08:02h | UTC