Neurology

Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data – The Lancet (link to abstract – $ for full-text)

“Patients with ischemic stroke 4·5–9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo. The rate of symptomatic intracerebral hemorrhage was higher with alteplase, but this increase did not negate the overall net benefit of thrombolysis.”

 

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Review: The Etiology of Bell’s Palsy

16 May, 2019 | 05:41h | UTC

“The Case of the Magician’s Sleight” – EMNerd (free)

See also: EXTEND Alteplase Shenanigans! – Emergency Medicine Literature of Note (free)

Original Study: Randomized Trial: Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke (link to abstract and commentary)

Related Cochrane Review: Thrombolysis for acute ischaemic stroke (free)

Related Review: Thrombolytics for stroke: The evidence – First10Em (free)

 

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State of the Art Review: Diagnosis and management of sensory polyneuropathy – The BMJ (free for a limited period)

 

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POEMS Syndrome: Clinical Update

9 May, 2019 | 08:02h | UTC

Optimal management after paediatric lumbar puncture: a randomized controlled trial – BMC Neurology (free)

Related Cochrane Review : Posture and fluids for preventing post‐dural puncture headache (free) AND Summary: Body position and intake of fluids for preventing headache after a lumbar puncture (free)

After a lumbar puncture in children, a shorter time (30 min) of fasting and lying supine without a pillow is not associated with a higher risk of post-lumbar puncture headache or lower back pain.

 


Update in Neurocritical Care

17 Apr, 2019 | 06:25h | UTC

EAN Guideline on Trigeminal Neuralgia

14 Mar, 2019 | 00:50h | UTC

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Commentary: The global burden of stroke: persistent and disabling – The Lancet Neurology (free)

 

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Television viewing and cognitive decline in older age: findings from the English Longitudinal Study of Ageing – Science Reports (free)

Commentaries: Expert reaction to study looking at watching TV and memory in over 50s – Science Media Centre (free) AND TV Viewing Tied to Cognitive Decline in Those Over Age 50 – NEJM Journal Watch (free)

 

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Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: An unparalleled assessment of the global burden of epilepsy (free)

 

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Global, regional, and national burden of multiple sclerosis 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: A global perspective on the burden of multiple sclerosis (free)

 

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Chronic pain as a symptom or a disease: The IASP Classification of Chronic Pain for the International Classification of Diseases (ICD-11) – Pain (free)

Commentary: IASP Updates Classification of Chronic Pain – Clinical Advisor (free)

 

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Guideline: Cerebral Palsy in Adults

16 Jan, 2019 | 00:37h | UTC

Vitamin and mineral supplementation for maintaining cognitive function in cognitively healthy people in mid and late life – Cochrane Library (free)

Summary: Vitamin and mineral supplementation for preventing cognitive deterioration in cognitively healthy people in mid and late life – Cochrane Library (free)

Commentary: Preventing dementia: do vitamin and mineral supplements have a role? – Evidently Cochrane (free)

 

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Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016 – New England Journal of Medicine (free)

Commentaries: New study reveals ‘startling’ risk of stroke – Institute for Health Metrics and Evaluation (free) AND 1 in 4 globally will have a stroke at age 25 or older, according to new study – CNN (free)

 

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Dual antiplatelet therapy with aspirin and clopidogrel for acute high risk transient ischaemic attack and minor ischaemic stroke – The BMJ (free)

Commentary: Guidelines Recommend Dual Antiplatelet Therapy Immediately After TIA or Minor Stroke NEJM Journal Watch (free)

 

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Global, regional, and national burden of Alzheimer’s disease and other dementias, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: Statistics on the burden of dementia: need for stronger data – The Lancet (free)

“In 2016, globally, 43·8 million individuals lived with dementia, increased from 20.2 million in 1990; dementia was the fifth leading cause of death globally (2·4 million) and more women than men had dementia” (via @TheLancet see Tweet with infographic)

 


Review: Intracranial Aneurysms

18 Nov, 2018 | 00:14h | UTC

Review: Neuroinfections Caused by Fungi

16 Nov, 2018 | 02:51h | UTC

Antipsychotic drug use and pneumonia: Systematic review and meta-analysis – Journal of Psychopharmacology (link to abstract – $ for full-text)

Commentary: Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests – Psychiatric News Alert (free)

“Although antipsychotic use was associated with a higher risk of pneumonia, the researchers stopped short of claiming causality, citing a lack of data from randomized, controlled trials and a failure of observational studies to control for relevant confounders like tobacco use and weight.” (from Psychiatric News Alert)

 


Podcast: Headaches Advanced Class

2 Nov, 2018 | 02:49h | UTC

Global, regional, and national burden of Parkinson’s disease, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: The burden of Parkinson’s disease: a worldwide perspective (free)

“In 2016, 6·1 million people worldwide had Parkinson’s disease, 2·9 million (48%) women & 3·2 million (52%) men; the increase in burden since 1990 was not exclusively explained by an increasing number of older people” (via @TheLancet see Tweet)

 


Modifying the consistency of food and fluids for swallowing difficulties in dementia – Cochrane Library (free for a limited period)

Summary: Modifying the consistency of food and fluids for swallowing difficulties in dementia (free)

“We are uncertain about the immediate and long-term effects of modifying the consistency of fluid for swallowing difficulties in dementia”

 


Podcast: Geriatric Depression

27 Sep, 2018 | 22:45h | UTC