Review: Pure Autonomic Failure

10 Oct, 2019 | 09:09h | UTC

Medical Management vs Mechanical Thrombectomy for Mild Strokes: An International Multicenter Study and Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Medical Therapy Vs Endovascular Therapy: Similar Outcomes for Mild Strokes – Neurology Today (free) AND Similar Benefits for Thrombectomy, Medical Management, in Mild Stroke – Medscape (free)


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Antiviral treatment for Bell’s palsy (idiopathic facial paralysis) – Cochrane Library (free)

Summary: Antiviral treatment for Bell’s palsy – Cochrane Library (free)

“The combination of antivirals and corticosteroids may have little or no effect on rates of incomplete recovery in comparison to corticosteroids alone”


Canadian Guideline for Parkinson Disease

10 Sep, 2019 | 01:52h | UTC

Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: ‘Silent’ strokes common after surgery, linked to cognitive decline – McMaster University (free) AND ‘Silent’ strokes after elective surgeries in older adults double their risk of later cognitive decline, study finds – The Globe and Mail (free)


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Long-term antithrombotic therapy and risk of intracranial haemorrhage from cerebral cavernous malformations: a population-based cohort study, systematic review, and meta-analysis – The Lancet Neurology (free)

Invited Commentary: Antithrombotics and bleeding risk: paradoxical findings (free)


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Podcast: Stroke and TIA Deconstructed

6 Aug, 2019 | 08:04h | UTC

NICE Guideline: Motor Neuron Disease

24 Jul, 2019 | 09:32h | UTC

Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis – Stroke (free)

Source: EvidenceAlerts

“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.


The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms – JAMA Neurology (free for a limited period)

Original Article: Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework – JAMA Neurology (free)


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How I manage intracranial hypertension – Critical Care (free)


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Preclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis? – JAMA Internal Medicine (free for a limited period)


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Quantity and quality of mental activities and the risk of incident mild cognitive impairment – Neurology (free PDF)

Commentary: Mentally stimulating activities linked to lower risk or delay of age-related memory loss – News Medical (free)


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Extending thrombolysis to 4·5–9 h and wake-up stroke using perfusion imaging: a systematic review and meta-analysis of individual patient data – The Lancet (link to abstract – $ for full-text)

“Patients with ischemic stroke 4·5–9 h from stroke onset or wake-up stroke with salvageable brain tissue who were treated with alteplase achieved better functional outcomes than did patients given placebo. The rate of symptomatic intracerebral hemorrhage was higher with alteplase, but this increase did not negate the overall net benefit of thrombolysis.”


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Review: The Etiology of Bell’s Palsy

16 May, 2019 | 05:41h | UTC

“The Case of the Magician’s Sleight” – EMNerd (free)

See also: EXTEND Alteplase Shenanigans! – Emergency Medicine Literature of Note (free)

Original Study: Randomized Trial: Thrombolysis Guided by Perfusion Imaging up to 9 Hours after Onset of Stroke (link to abstract and commentary)

Related Cochrane Review: Thrombolysis for acute ischaemic stroke (free)

Related Review: Thrombolytics for stroke: The evidence – First10Em (free)


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State of the Art Review: Diagnosis and management of sensory polyneuropathy – The BMJ (free for a limited period)


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POEMS Syndrome: Clinical Update

9 May, 2019 | 08:02h | UTC

Optimal management after paediatric lumbar puncture: a randomized controlled trial – BMC Neurology (free)

Related Cochrane Review : Posture and fluids for preventing post‐dural puncture headache (free) AND Summary: Body position and intake of fluids for preventing headache after a lumbar puncture (free)

After a lumbar puncture in children, a shorter time (30 min) of fasting and lying supine without a pillow is not associated with a higher risk of post-lumbar puncture headache or lower back pain.


Update in Neurocritical Care

17 Apr, 2019 | 06:25h | UTC

EAN Guideline on Trigeminal Neuralgia

14 Mar, 2019 | 00:50h | UTC

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Commentary: The global burden of stroke: persistent and disabling – The Lancet Neurology (free)


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Television viewing and cognitive decline in older age: findings from the English Longitudinal Study of Ageing – Science Reports (free)

Commentaries: Expert reaction to study looking at watching TV and memory in over 50s – Science Media Centre (free) AND TV Viewing Tied to Cognitive Decline in Those Over Age 50 – NEJM Journal Watch (free)


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Global, regional, and national burden of epilepsy, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016 – The Lancet Neurology (free)

Invited Commentary: An unparalleled assessment of the global burden of epilepsy (free)


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