Nephrology
Clinical Trial Update | Equal long-term health and survival from restrictive vs. standard IV fluid therapy in septic shock patients
29 Jun, 2023 | 14:01h | UTCOriginal Study: RCT: A restrictive intravenous fluid strategy does not improve outcomes in ICU patients with septic shock.
Cohort Study | Younger adults with modest kidney function reductions show increased risk of adverse outcomes
28 Jun, 2023 | 13:14h | UTCSummary: This study was a retrospective, population-based cohort study exploring the implications of modest reductions in estimated glomerular filtration rate (eGFR) in young adults. The study was conducted on 8.7 million adult residents aged 18-65 years in Ontario, Canada, with no history of kidney disease. Data was collected from January 2008 to March 2021.
The research revealed that 18.0% of those aged 18-39, 18.8% of those aged 40-49, and 17.0% of those aged 50-65 had modestly reduced eGFR measurements specific to their age group. Adverse outcomes, including all-cause mortality, cardiovascular events, and kidney failure, were consistently higher by hazard ratio and incidence for ages 18-39 across all eGFR categories, compared to older groups. The hazard ratio for modest reductions (eGFR 70-80 mL/min/1.73m2) was found to be 1.42 for ages 18-39 years.
The findings suggest that even modest reductions in kidney function can significantly impact younger adults, necessitating frequent monitoring of kidney function in this demographic to prevent chronic kidney disease and its complications. It is noteworthy, however, that potential limitations of this study include possible misclassification of comorbidities, unmeasured confounding, and a lack of insight into the mechanism of these modest eGFR reductions.
News Release: Even a modest reduction in kidney function increases health risks in young adults – University of Ottawa
KDOQI US commentary on the 2021 KDIGO clinical practice guideline for the management of glomerular diseases
28 Jun, 2023 | 13:07h | UTCOriginal Guideline: KDIGO 2021 clinical practice guideline for the management of glomerular diseases – Kidney Disease: Improving Global Outcomes
Review | Renal thrombotic microangiopathy
27 Jun, 2023 | 13:34h | UTCRenal Thrombotic Microangiopathy: A Review – American Journal of Kidney Diseases
Commentary on Twitter
Renal Thrombotic Microangiopathy: A Review https://t.co/YabUm18t4q (FREE)@CPQMD @ReichHeather @UofTNephrology pic.twitter.com/Y9rSnuTFBo
— AJKD (@AJKDonline) June 24, 2023
Scientific Advisory | Expedited CT scanning with iodinated contrast when necessary favored over renal concerns in emergencies
22 Jun, 2023 | 15:19h | UTCRelated:
Radiographic Contrast Media and the Kidney – Clinical Journal of the American Society of Nephrology
Contrast-Associated Acute Kidney Injury – Journal of Clinical Medicine
M-A | Anticoagulation options for continuous renal replacement therapy in critically ill patients
22 Jun, 2023 | 14:54h | UTC
Review | Glomerular hematuria and the utility of urine microscopy
21 Jun, 2023 | 13:14h | UTC
Commentary on Twitter
Glomerular Hematuria and the Utility of Urine Microscopy: A Reviewhttps://t.co/SsibhaJqnY (FREE)@MLReynoldsMD @AmyMottl @ANCAUNC @VDereBean pic.twitter.com/kEhmKSL2Ij
— AJKD (@AJKDonline) June 11, 2023
RCT | High-dose hemodiafiltration reduces mortality risk in kidney failure patients compared to conventional high-flux hemodialysis
19 Jun, 2023 | 14:17h | UTCEffect of Hemodiafiltration or Hemodialysis on Mortality in Kidney Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
#ERA23: In patients with kidney failure undergoing kidney-replacement therapy, the use of high-dose hemodiafiltration resulted in lower mortality than conventional high-flux hemodialysis. Full results of the CONVINCE trial: https://t.co/NRtQnHm9vo
— NEJM (@NEJM) June 16, 2023
RCT | Adding bio-impedance to fluid management fails to enhance kidney function preservation in new hemodialysis patients
19 Jun, 2023 | 14:01h | UTC
M-A | Anticoagulation options for continuous renal replacement therapy in critically ill patients
19 Jun, 2023 | 13:51h | UTC
RCT | Multiple electrolytes solution reduces acute kidney injury in pediatric septic shock compared to saline
16 Jun, 2023 | 14:10h | UTCMultiple Electrolytes Solution Versus Saline as Bolus Fluid for Resuscitation in Pediatric Septic Shock: A Multicenter Randomized Clinical Trial – Critical Care Medicine (link to abstract – $ for full-text)
Cohort Study | Identification of an optimal threshold to define oliguria in critically ill patients
15 Jun, 2023 | 15:05h | UTC
Commentary on Twitter
Identification of an optimal threshold to define oliguria in critically ill patients
Read the full article: https://t.co/4msRdcWZYY@jlvincen @ISICEM #FOAMed #FOAMcc pic.twitter.com/5PfiXkE5FO
— Critical Care (@Crit_Care) June 9, 2023
RCT | No significant kidney outcome differences observed across glucose-lowering medications in T2D patients
15 Jun, 2023 | 15:02h | UTCComparative Effects of Glucose-Lowering Medications on Kidney Outcomes in Type 2 Diabetes: The GRADE Randomized Clinical Trial – JAMA Internal Medicine (link to abstract – $ for full-text)
See also: Visual Abstract
Commentaries:
No differences found in effects of secondary diabetes drugs on kidney outcomes – ACP Diabetes
Do glucose-lowering medications have different effects on kidney outcomes? – News Medical
RCT | No change in delayed graft function with normothermic perfusion vs. cold storage in kidney transplants
13 Jun, 2023 | 14:00h | UTC
Commentary on Twitter
In an open-label, randomized controlled trial, normothermic machine perfusion of kidneys from donation after circulatory death was found to be feasible and safe but did not reduce the rate of delayed graft function compared to static cold storage. https://t.co/faaAzK3bpc pic.twitter.com/iL7Je7Z7jO
— Nature Medicine (@NatureMedicine) June 2, 2023
Review | Volume management with kidney replacement therapy in the critically ill patient
12 Jun, 2023 | 13:43h | UTC
RCT | Letermovir demonstrates noninferiority to valganciclovir for CMV prophylaxis in kidney transplantation
12 Jun, 2023 | 13:38h | UTCLetermovir vs Valganciclovir for Prophylaxis of Cytomegalovirus in High-Risk Kidney Transplant Recipients: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: A New Antiviral Option for Cytomegalovirus Prevention After Kidney Transplant – JAMA (free for a limited period)
See also: Visual Abstract
Review | Portable, wearable and implantable artificial kidney systems: needs, opportunities and challenges
12 Jun, 2023 | 13:30h | UTCPortable, wearable and implantable artificial kidney systems: needs, opportunities and challenges – Nature Reviews Nephrology (if the link is paywalled, try this one)
Magnetic resonance imaging to evaluate kidney structure, function, and pathology: moving towards clinical application
7 Jun, 2023 | 13:57h | UTC
Review | Hypovolemia with peripheral edema: what is wrong?
5 Jun, 2023 | 13:18h | UTCHypovolemia with peripheral edema: What is wrong? – Critical Care
M-A | Hypoxia-inducible factor stabilizers’ effects on lab parameters and outcomes in CKD patients with renal anemia
5 Jun, 2023 | 13:00h | UTC
Consensus Document | Diagnosis and treatment of lupus nephritis
2 Jun, 2023 | 12:26h | UTC
Expert Consensus | Nephrotoxic potential of 195 medications in the non-intensive care setting
1 Jun, 2023 | 12:14h | UTC
Proposing a new five-type classification for glomerulonephritis based on pathogenesis, activity, and chronicity
31 May, 2023 | 14:11h | UTC
Commentary on Twitter
The five types of glomerulonephritis classified by pathogenesis, activity & chronicity (GN-AC)
?https://t.co/NYKBde4L1I
?The major entities of GN
?Autoantigens in autoimmune GN
?Multilevel diagnostic algorithm of GN
?Proposed GN-AC classification & reporting system for GN pic.twitter.com/shmLLhCfJk— NDT (@NDTsocial) May 24, 2023
Review | Spurious electrolyte and acid-base disorders in the patient with cancer
30 May, 2023 | 11:43h | UTC
Commentary on Twitter
Spurious Electrolyte and Acid-Base Disorders in the Patient With Cancer: A Review https://t.co/i9jPRxBdkz (FREE) @raad_chowdhury @NephroMD @bdubNephro @PITTRenal pic.twitter.com/FbhovMDHd7
— AJKD (@AJKDonline) May 27, 2023
ISPD Catheter-related infection recommendations
29 May, 2023 | 11:00h | UTCISPD Catheter-related Infection Recommendations: 2023 Update – Peritoneal Dialysis International