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Internal Medicine

M-A | P2Y12 inhibitors show superior efficacy over aspirin for secondary prevention in CAD

11 Jul, 2023 | 14:06h | UTC

P2Y12 Inhibitor or Aspirin Monotherapy for Secondary Prevention of Coronary Events – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Related:

Monotherapy with a P2Y12 inhibitor or aspirin for secondary prevention in patients with established atherosclerosis: a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

RCT | Clopidogrel is better than Aspirin for chronic maintenance monotherapy after percutaneous coronary intervention.

Meta-analysis of randomized trials: Clopidogrel is better than aspirin for the secondary prevention of cardiovascular events.

#ACC21 – RCT: Clopidogrel better than aspirin for chronic maintenance monotherapy after percutaneous coronary intervention.

 

Commentary on Twitter

 


Cohort Study | Long-term use of menopausal hormone therapy linked to heightened dementia risk

11 Jul, 2023 | 14:04h | UTC

Menopausal hormone therapy and dementia: nationwide, nested case-control study – The BMJ

Editorial: Menopausal hormone therapy and dementia – The BMJ

News Release: Menopausal hormone therapy linked to increased rate of dementia – BMJ Newsroom

Commentaries: Expert reaction to observational study on HRT and dementia – Science Media Centre

 


Cohort Study | Fewer than half of new drugs add substantial therapeutic value over existing treatments

11 Jul, 2023 | 14:01h | UTC

News Release: Fewer than half of new drugs add substantial therapeutic value over existing treatments – BMJ Newsroom

Article: Therapeutic value of first versus supplemental indications of drugs in US and Europe (2011-20): retrospective cohort study – The BMJ

Editorial: Patients need better treatments, not just more of the same – The BMJ

 


AASLD Guidance | Use of TIPS, variceal embolization, and retrograde transvenous obliteration in variceal hemorrhage

11 Jul, 2023 | 13:59h | UTC

AASLD Practice Guidance on the Use of TIPS, Variceal Embolization, and Retrograde Transvenous Obliteration in the Management of Variceal Hemorrhage – Hepatology

 


Practice Recommendation | Strategies to prevent MRSA transmission and infection in hospitals

10 Jul, 2023 | 14:02h | UTC

SHEA/IDSA/APIC Practice Recommendation: Strategies to prevent methicillin-resistant Staphylococcus aureus transmission and infection in acute-care hospitals: 2022 Update – Infection Control & Hospital Epidemiology

News Release: Updated guidance shows how hospitals should protect patients from resistant infections – Society for Healthcare Epidemiology of America

Commentary: New guidelines recommend antibiotic stewardship for preventing MRSA – CIDRAP

 


Guideline | Acute liver failure

10 Jul, 2023 | 13:59h | UTC

Acute Liver Failure Guidelines – The American Journal of Gastroenterology

Related:

EASL Clinical Practice Guidelines on acute-on-chronic liver failure – Journal of Hepatology

Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU

Acute-on-chronic liver failure: far to go—a review – Critical Care

 


RCT | Dual antiplatelet therapy proves noninferior to alteplase in minor ischemic stroke

10 Jul, 2023 | 13:58h | UTC

Dual Antiplatelet Therapy vs Alteplase for Patients With Minor Nondisabling Acute Ischemic Stroke: The ARAMIS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

See also: Visual Abstract

Commentary: ARAMIS Clinical Trial Demonstrates the Noninferiority of Dual Antiplatelet Therapy Compared with Intravenous Activase in Patients with Minor Nondisabling Acute Ischemic Stroke – Practical Neurology

 


RCT | No significant difference in weight loss between intermittent fasting and calorie restriction

10 Jul, 2023 | 13:56h | UTC

Time-Restricted Eating Without Calorie Counting for Weight Loss in a Racially Diverse Population: A Randomized Controlled Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Intermittent fasting and traditional calorie counting shown to be about equal for weight loss – American College of Physicians

Commentary: Intermittent fasting and calorie counting about equal for weight loss – new study – The Conversation

Related:

RCT | Intermittent fasting plus early time-restricted eating vs. calorie restriction and standard care in adults at risk of type 2 DM

RCT | Time-restricted eating not more effective than daily calorie restriction for managing nonalcoholic fatty liver disease

Health effects of the time-restricted eating in adults with obesity: A systematic review and meta-analysis – Frontiers in Nutrition

Time-restricted eating and exercise training improve HbA1c and body composition in women with overweight/obesity: A randomized controlled trial – Cell Metabolism

Effectiveness of Early Time-Restricted Eating for Weight Loss, Fat Loss, and Cardiometabolic Health in Adults With Obesity: A Randomized Clinical Trial – JAMA Internal Medicine

Effects of Intermittent Fasting in Human Compared to a Non-intervention Diet and Caloric Restriction: A Meta-Analysis of Randomized Controlled Trials – Frontiers in Nutrition

Time-Restricted Eating: Integrating The What With The When – Advances in Nutrition

Calorie Restriction with or without Time-Restricted Eating in Weight Loss- New England Journal of Medicine

Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials – JAMA Network Open

 


Cohort Study | A diet high in fruits, vegetables, nuts, legumes, fish, and dairy linked with decreased mortality and CVD globally

10 Jul, 2023 | 13:39h | UTC

Diet, cardiovascular disease, and mortality in 80 countries – European Heart Journal

Editorial: Identifying nutritional priorities for global health: time for a more PURE focus on protective foods – European Heart Journal

News Release: Global diet study challenges advice to limit high-fat dairy foods – European Society of Cardiology

 

Commentary on Twitter

 


Review | Evaluation of acute adult disorders of consciousness for the general intensivist

10 Jul, 2023 | 13:37h | UTC

State-of-the-Art Evaluation of Acute Adult Disorders of Consciousness for the General Intensivist – Critical Care Medicine (free for a limited period)

 


Personalized nutrition therapy in critical care: 10 expert recommendations

10 Jul, 2023 | 13:36h | UTC

Personalized nutrition therapy in critical care: 10 expert recommendations – Critical Care

 


How to avoid harm with feeding critically ill patients: a synthesis of viewpoints of a basic scientist, dietitian and intensivist

10 Jul, 2023 | 13:34h | UTC

How to avoid harm with feeding critically ill patients: a synthesis of viewpoints of a basic scientist, dietitian and intensivist – Critical Care

 


Cohort Study | Hypertensive disorders of pregnancy linked to a 66% higher stroke risk in U.S. black women

10 Jul, 2023 | 13:31h | UTC

Hypertensive Disorders of Pregnancy and Risk of Stroke in U.S. Black Women – NEJM Medicine

Commentary: Black women with history of hypertensive disorders of pregnancy have 66% increased risk of stroke, study finds – News Medical

 


M-A | Efficacy of varenicline versus bupropion for smoking cessation

10 Jul, 2023 | 13:23h | UTC

Efficacy of varenicline versus bupropion for smoking cessation: A systematic review and meta-analysis of randomized controlled trials – Indian Journal of Psychiatry

 


Podcast | Untangling catheter associated UTIs

10 Jul, 2023 | 13:21h | UTC

#402 Don’t Get Caught with a CAUTI – The Curbsiders

 


Podcast | Updates in addiction medicine

10 Jul, 2023 | 13:17h | UTC

#401 Updates in Addiction Medicine – SGIM 2023 – The Curbsiders

 


Consensus Paper | Subcutaneous infusions of hydration and medication in adults

7 Jul, 2023 | 16:27h | UTC

International Consensus Recommendation Guidelines for Subcutaneous Infusions of Hydration and Medication in Adults: An e-Delphi Consensus Study – Journal of Infusion Nursing

 


RCT | Semont-plus maneuver yields faster recovery than Epley maneuver in posterior canal BPPV

7 Jul, 2023 | 16:26h | UTC

The Semont-Plus Maneuver or the Epley Maneuver in Posterior Canal Benign Paroxysmal Positional Vertigo: A Randomized Clinical Study – JAMA Neurology (link to abstract – $ for full-text)

See also: Visual Abstract

Videos:

Demonstration of the Semont-Plus Self-maneuver for Right Posterior Canal Canalithiasis

Semont-Plus Maneuver for Right Posterior Canal Benign Paroxysmal Positional Vertigo

Demonstration of the Epley Self-maneuver for a Right Posterior Canal Canalithiasis

Commentary: Semont-plus Meneuver Offered Faster Recovery for Benign Paroxysmal Positional Vertigo – Neurology Today

 


RCT | Weekly Tirzepatide outperforms placebo in weight management for type 2 diabetes patients

7 Jul, 2023 | 16:24h | UTC

Tirzepatide once weekly for the treatment of obesity in people with type 2 diabetes (SURMOUNT-2): a double-blind, randomised, multicentre, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Tirzepatide triumphs in significant weight reduction for people with type 2 diabetes – News Medical

 


Review | Post-COVID Conditions

7 Jul, 2023 | 16:21h | UTC

Post-COVID Conditions – Mayo Clinic Proceedings

 


Review | Management of premature ventricular complexes in the outpatient setting

7 Jul, 2023 | 16:22h | UTC

Management of Premature Ventricular Complexes in the Outpatient Setting – Mayo Clinic Proceedings

 


Review | Cardiovascular outcomes in patients with diabetes and kidney disease

7 Jul, 2023 | 16:13h | UTC

Cardiovascular Outcomes in Patients With Diabetes and Kidney Disease: JACC Review Topic of the Week – Journal of the American College of Cardiology

 


Review | Acute-on-chronic liver failure

7 Jul, 2023 | 16:09h | UTC

Acute-on-chronic liver failure: far to go—a review – Critical Care

Related:

EASL Clinical Practice Guidelines on acute-on-chronic liver failure – Journal of Hepatology

Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU

 


Review | Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA): two sides of the same coin

7 Jul, 2023 | 16:01h | UTC

HES and EGPA: Two Sides of the Same Coin – Mayo Clinic Proceedings

 


ASA Consensus Guidance | Preoperative management of patients on GLP-1 agonists

5 Jul, 2023 | 01:17h | UTC

American Society of Anesthesiologists Consensus-Based Guidance on Preoperative Management of Patients (Adults and Children) on Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists – American Society of Anesthesiologists

Commentary: Anesthesiologists Say Ozempic, Wegovy Should Be Halted Prior to Surgery – HealthDay

 


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