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Internal Medicine

Review | Updates on infectious and other complications in peritoneal dialysis

26 Jul, 2023 | 13:23h | UTC

Updates on Infectious and Other Complications in Peritoneal Dialysis: Core Curriculum 2023 – American Journal of Kidney Diseases (free for a limited period)

Related: ISPD Catheter-related Infection Recommendations: 2023 Update – Peritoneal Dialysis International

 

Commentary on Twitter

 

Giving a voice to patients at high risk of dying in the intensive care unit: a multiple source approach

26 Jul, 2023 | 13:20h | UTC

Giving a voice to patients at high risk of dying in the intensive care unit: a multiple source approach – Intensive Care Medicine (free for a limited period)

 

Commentary on Twitter

 

M-A | P2Y12 monotherapy after 1-3 months DAPT safely reduces bleeding in PCI patients with CAD and CKD

26 Jul, 2023 | 13:18h | UTC

P2y12 inhibitor monotherapy after 1–3 months dual antiplatelet therapy in patients with coronary artery disease and chronic kidney disease undergoing percutaneous coronary intervention: a meta-analysis of randomized controlled trials – Frontiers in Cardiovascular Medicine

Related:

De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a Consensus Statement from an international expert panel on coronary thrombosis – Nature Reviews Cardiology (if the link is paywalled, try this one)

RCT | 3-6 month DAPT noninferior to 12 month DAPT in patients undergoing PCI with third-generation DES

Short Duration of DAPT Versus De-Escalation After Percutaneous Coronary Intervention for Acute Coronary Syndromes – JACC: Cardiovascular Interventions

Long-term Effects of P2Y12 Inhibitor Monotherapy After Percutaneous Coronary Intervention: 3-Year Follow-up of the SMART-CHOICE Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI: The STOPDAPT-2 Randomized Clinical Trial – JAMA

Effect of P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention: The SMART-CHOICE Randomized Clinical Trial – JAMA

Comparison of Clopidogrel Monotherapy After 1 to 2 Months of Dual Antiplatelet Therapy With 12 Months of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome: The STOPDAPT-2 ACS Randomized Clinical Trial – JAMA Cardiology

Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial – The BMJ

6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (SMART-DATE): a randomised, open-label, non-inferiority trial – The Lancet

Dual Antiplatelet Therapy Duration Based on Ischemic and Bleeding Risks After Coronary Stenting – Journal of the American College of Cardiology

 

M-A | Vegetarian diets may modestly improve cardiometabolic profile in high-risk individuals

26 Jul, 2023 | 13:15h | UTC

Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular Disease: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: M-A: Vegetarian diets may modestly improve cardiometabolic profile in high-risk individuals – HCP Live

 

Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis

26 Jul, 2023 | 13:11h | UTC

Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis – European Heart Journal (free for a limited period)

 

Commentary on Twitter

 

RCT | Vitamin D supplementation shows no cognitive benefit in mild cognitive impairment intervention

25 Jul, 2023 | 14:00h | UTC

Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial – JAMA Network Open

Commentary: Exercise and Cognitive Training Slow Thinking Declines. Vitamin D? Not So Much – HealthDay

Related:

RCT | No statistically significant impact of vitamin D on major cardiovascular events

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

 

Cohort Study | BMI of 25.0–29.9 not linked with higher mortality in 21st century U.S. adults

25 Jul, 2023 | 13:58h | UTC

Body mass index and all-cause mortality in a 21st century U.S. population: A National Health Interview Survey analysis – PLOS One

News Release: No increase in mortality for most overweight people, study finds – PLOS

Commentary: Expert reaction to study looking at BMI and all-cause mortality – Science Media Centre

 

Research Findings | US annual serious harms from misdiagnosis estimated at 795K in recent study

25 Jul, 2023 | 13:57h | UTC

Burden of serious harms from diagnostic error in the USA – BMJ Quality & Safety (link to abstract – $ for full-text)

News Release: Report Highlights Public Health Impact of Serious Harms From Diagnostic Error in U.S. – Johns Hopkins Medicine

Commentaries:

Majority of medical misdiagnoses occur in patients with less obvious disease manifestations – MedicalResearch

Misdiagnoses cost the U.S. 800,000 deaths and serious disabilities every year, study finds – STAT

 

Global, regional, and national burden of meningitis and its etiologies, 1990–2019

25 Jul, 2023 | 13:55h | UTC

Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet Neurology

 

Commentary on Twitter

 

Consensus Paper | Urinary tract infections in pregnant individuals

25 Jul, 2023 | 13:53h | UTC

Urinary Tract Infections in Pregnant Individuals – Obstetrics & Gynecology

 

Cohort Study | Examining patient demographics, microbiology, and mortality in infectious endocarditis after TAVI

25 Jul, 2023 | 13:48h | UTC

Patient characteristics, microbiology, and mortality of infective endocarditis after transcatheter aortic valve implantation – Clinical Infectious Diseases

 

M-A | Early initiation of renal replacement therapy fails to improve survival rates in AKI patients

25 Jul, 2023 | 13:46h | UTC

Early strategy vs. late initiation of renal replacement therapy in adult patients with acute kidney injury: an updated systematic review and meta-analysis of randomized controlled trials – European Review for Medical and Pharmacological Sciences

 

Cohort Study | Association found between carpal tunnel syndrome and heart failure incidence

25 Jul, 2023 | 13:42h | UTC

Association Between Carpal Tunnel Syndrome and Subsequent Heart Failure Among Adults in Germany – JAMA Network Open

Commentary: Carpal Tunnel Syndrome Again Tied to Heart Failure: German Data – TCTMD

 

Systematic Review | Existing research on post-stroke depression interventions lacks conclusive results

25 Jul, 2023 | 13:37h | UTC

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating depression after stroke – Cochrane Library

Summary: Pharmacological, non-invasive brain stimulation and psychological interventions for treating depression after stroke – Cochrane Library

 

New WHO guidance on the role of HIV viral suppression in improving individual health and reducing transmission

24 Jul, 2023 | 13:17h | UTC

News Release: New WHO guidance on HIV viral suppression and scientific updates released at IAS 2023 – World Health Organization

WHO Guidance: The role of HIV viral suppression in improving individual health and reducing transmission – Word Health Organization

Related WHO Guidelines:

WHO recommends optimizing HIV testing services – World Health Organization

Primary health care and HIV: convergent actions – World Health Organization

 

Systematic Review | Low-level HIV viremia (below 1000 copies/mL) linked to minimal sexual transmission risk

24 Jul, 2023 | 13:15h | UTC

The risk of sexual transmission of HIV in individuals with low-level HIV viraemia – The Lancet

Editorial: HIV is sexually untransmittable when viral load is undetectable – The Lancet

Related: Study: Growing Acceptability of “Undetectable = Untransmittable” but Widespread Misunderstanding of HIV Transmission Risk Persists (several texts on the subject)

 

Commentary on Twitter

 

Consensus Paper | De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and PCI

24 Jul, 2023 | 13:08h | UTC

De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a Consensus Statement from an international expert panel on coronary thrombosis – Nature Reviews Cardiology (if the link is paywalled, try this one)

 

Systematic Review | Dual therapy of Rifaximin and lactulose potentially reduces risk in hepatic encephalopathy

24 Jul, 2023 | 12:57h | UTC

Rifaximin for prevention and treatment of hepatic encephalopathy in people with cirrhosis – Cochrane Library

Summary: Rifaximin for prevention and treatment of hepatic encephalopathy in people with cirrhosis – Cochrane Library

 

Systematic Review | Insufficient evidence for ACEi/ARB’s impact on early non-diabetic CKD

24 Jul, 2023 | 12:56h | UTC

Angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non‐diabetic chronic kidney disease – Cochrane Library

Summary: Blood pressure lowering medication for adults with early stages of chronic kidney disease (without diabetes) – Cochrane Library

 

Review | Research on prescribing cascades

24 Jul, 2023 | 12:53h | UTC

Research on prescribing cascades: a scoping review – Frontiers in Pharmacology

 

RCT | Long-term Doxycycline for COPD does not reduce exacerbations, except possibly in severe cases or with low eosinophils

24 Jul, 2023 | 12:50h | UTC

A Double-Blind, Randomised, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable COPD – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

 

2023 AHA/ACC Guideline for chronic coronary disease – B-blockers downgraded in patients without recent MI or low ejection fraction

21 Jul, 2023 | 13:52h | UTC

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines – Journal of the American College of Cardiology

Key Perspectives: 2023 Multisociety Guideline for Managing Chronic Coronary Disease – American College of Cardiology

Top things to know: 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease – American Heart Association

News Releases:

Symptom relief and healthy habits are top goals for treating chronic heart disease – American Heart Association

New ACC, AHA, Multi-Society Guideline Addresses Management of Chronic Coronary Disease – American College of Cardiology

Commentary: New Chronic Heart Disease Guidelines Update Roles of GDMT, Imaging, and Revascularization – TCTMD

 

Commentary on Twitter with key points (thread – click for more)

 

Guideline | Laboratory analysis in the diagnosis and management of diabetes mellitus

21 Jul, 2023 | 13:50h | UTC

Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

 

Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19

21 Jul, 2023 | 13:43h | UTC

Potential “Healthy Vaccinee Bias” in a Study of BNT162b2 Vaccine against Covid-19 – New England Journal of Medicine

 

Commentary from the author on Twitter (thread – click for more)

 

RCT | MIND diet, a hybrid of Mediterranean and DASH, shows no superiority in preventing cognitive decline

21 Jul, 2023 | 13:38h | UTC

Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

‘MIND diet,’ intended to prevent dementia, doesn’t offer significant brain benefit, trial suggests – Live Science

Revised Mediterranean Diet Shows No Significant Impact on Cognition, MRI Outcomes in Older Persons – Neurology Live

 

Commentary on Twitter

 

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