Internal Medicine
RCT | Dupilumab improves lung function and reduces exacerbations in COPD patients with elevated eosinophils
1 Jun, 2023 | 12:20h | UTCDupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Dupilumab Improves Outcomes for COPD, Type 2 Inflammation in Randomized Trial – HCP Live
Commentary on Twitter
Presented at #ATS2023: In the BOREAS trial, dupilumab resulted in a lower annualized rate of exacerbations than placebo among patients with COPD and an elevated blood eosinophil count. Full trial results: https://t.co/9IWZr3YqsN
— NEJM (@NEJM) May 21, 2023
Phase 2b RCT | Danuglipron, an oral GLP-1R agonist, reduces body weight and improves glycemic control in type 2 diabetes
1 Jun, 2023 | 12:17h | UTC
SR | Systematic review finds 16.4-36.18 severe bleedings, 7.62-8.5 perforations per 10,000 colonoscopies
1 Jun, 2023 | 12:15h | UTC
Expert Consensus | Nephrotoxic potential of 195 medications in the non-intensive care setting
1 Jun, 2023 | 12:14h | UTC
M-A | Noninvasive ventilation in patients with acute hypoxemic respiratory failure
1 Jun, 2023 | 12:11h | UTC
Review | Deprescribing interventions for gabapentinoids in adults
1 Jun, 2023 | 12:05h | UTC
Guideline | Onychomycosis
1 Jun, 2023 | 12:01h | UTCGuideline onychomycosis – Journal of the German Society of Dermatology
RCT | Adapted mindfulness training shows efficacy in reducing elevated office blood pressure
1 Jun, 2023 | 12:03h | UTC
Cluster RCT | Point-of-care CRP testing cuts antibiotic prescriptions in respiratory illnesses in primary care
1 Jun, 2023 | 11:58h | UTCCommentary: Use of CRP testing reduced antibiotics for respiratory infections, trial finds – CIDRAP
Study finds potential glaucoma risk in patients using calcium channel blockers
1 Jun, 2023 | 11:51h | UTCCommentary: Calcium Channel Blocker Use Associated with Higher Prevalence of Glaucoma – HCP Live
RCT | Prophylactic platelet transfusion reduces CVC-related bleeding in patients with platelets 10-50 K/mm³
31 May, 2023 | 14:20h | UTCPlatelet Transfusion before CVC Placement in Patients with Thrombocytopenia – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Withholding of prophylactic platelet transfusion before CVC placement in pts with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority & resulted in more CVC-related bleeding events than prophylactic platelet transfusion.
— NEJM (@NEJM) May 27, 2023
RCT | Early initiation of DOACs not statistically superior to later use in atrial fibrillation-related stroke
31 May, 2023 | 14:17h | UTCEarly versus Later Anticoagulation for Stroke with Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
ELAN: Early DOACs Safe, May Help After Ischemic Stroke in AF Patients – TCTMD
Commentary on Twitter
Late breaking at #ESOC2023: In the ELAN trial, the estimated incidence of stroke, systemic embolism, hemorrhage, or death was 2.8 percentage points lower to 0.5 percentage points higher with early than with later use of direct oral anticoagulants. Full results:
— NEJM (@NEJM) May 24, 2023
RCT | P2Y12 inhibitors don’t improve outcomes in critically ill COVID-19 patients
31 May, 2023 | 14:13h | UTCSee also: Visual Abstract
Proposing a new five-type classification for glomerulonephritis based on pathogenesis, activity, and chronicity
31 May, 2023 | 14:11h | UTC
Commentary on Twitter
The five types of glomerulonephritis classified by pathogenesis, activity & chronicity (GN-AC)
?https://t.co/NYKBde4L1I
?The major entities of GN
?Autoantigens in autoimmune GN
?Multilevel diagnostic algorithm of GN
?Proposed GN-AC classification & reporting system for GN pic.twitter.com/shmLLhCfJk— NDT (@NDTsocial) May 24, 2023
Guidelines | Management of ascites in liver disease
31 May, 2023 | 14:08h | UTC
Review | How to approach acute thrombosis and thrombocytopenia
31 May, 2023 | 14:03h | UTCHow to approach acute thrombosis and thrombocytopenia – Clinical Medicine Journal
Cohort Study | Prevalence and risk factors of significant persistent pain symptoms after critical care illness
31 May, 2023 | 14:00h | UTC
Cohort Study | NT‐proBNP and all-cause and cardiovascular mortality
31 May, 2023 | 13:59h | UTC
The WHO AWaRe (Access, Watch, Reserve) antibiotic book
30 May, 2023 | 12:09h | UTCThe WHO AWaRe (Access, Watch, Reserve) antibiotic book – World Health Organization
Review | Intravenous fluids in critically ill patients: when less is better
31 May, 2023 | 13:45h | UTCIntravenous Fluids in Critically Ill Patients: When Less is Better – ICU Management & Practice
RCT | Sulbactam-durlobactam non-inferior to colistin in reducing 28-day mortality from carbapenem-resistant ABC
30 May, 2023 | 12:08h | UTCEfficacy and safety of sulbactam–durlobactam versus colistin for the treatment of patients with serious infections caused by Acinetobacter baumannii–calcoaceticus complex: a multicentre, randomised, active-controlled, phase 3, non-inferiority clinical trial (ATTACK) – The Lancet Infectious Diseases (link to abstract – $ for full-text)
News Release: Novel antibiotic succeeds in trial against hospital-acquired pneumonia – Rutgers University
RCT | Care bundle with intensive blood pressure control improves outcomes in acute cerebral hemorrhage
30 May, 2023 | 12:04h | UTC
Cohort Study | Amiodarone linked to higher bleeding risk vs. flecainide or sotalol in atrial fibrillation patients on anticoagulants
30 May, 2023 | 12:01h | UTCRisk for Bleeding-Related Hospitalizations During Use of Amiodarone With Apixaban or Rivaroxaban in Patients With Atrial Fibrillation: A Retrospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary on Twitter
A study of older adults with #AFib who were treated with #anticoagulants found #amiodarone during apixaban/rivaroxaban use was associated with greater risk for bleeding-related #hospitalizations compared to flecainide or sotalol: https://t.co/cFb1rgGqjt pic.twitter.com/gKlgLXBdb2
— Annals of Int Med (@AnnalsofIM) May 25, 2023
Review | Treatment of Enterococcus faecalis infective endocarditis
30 May, 2023 | 11:54h | UTCTreatment of Enterococcus faecalis Infective Endocarditis: A Continuing Challenge – Antibiotics
Scientific Statement | Acute heart failure and valvular heart disease
30 May, 2023 | 11:53h | UTC