Internal Medicine

Review: Hepatorenal Syndrome

24 Apr, 2019 | 06:21h | UTC

Clinical Update: Metformin in 2019

23 Apr, 2019 | 01:50h | UTC

Metformin in 2019 – JAMA (free for a limited period)

 


Review: Clostridium Difficile Infection

21 Apr, 2019 | 21:16h | UTC

Measles cases are up nearly 300% from last year. This is a global crisis – CNN (free)

WHO Statement: New measles surveillance data for 2019 – World Health Organization (free)

By Henrietta H Fore (executive director of UNICEF) and Tedros Adhanom Ghebreyesus (director general of the World Health Organization).

 


Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (free for a limited period)

Commentary: Canagliflozin may offer renal protection in people with type 2 diabetes and CKD – Medicine Matters (free)

“among 1000 patients treated for 2.5 years, 21.2 individuals would need to be treated to prevent the composite primary outcome.” (from Medicine Matters)

 


EASL Clinical Practice Guidelines: Drug-induced liver injury – Journal of Hepatology (free)

Related Review: Drug-induced liver injury: recent advances in diagnosis and risk assessment – Gut (free)

 

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Ann Robinson’s research reviews, 9 April 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


BMJ Review: Depression in Primary Care

9 Apr, 2019 | 02:11h | UTC

State of the Art Review: Depression in primary care: part 1—screening and diagnosis – The BMJ (free for a limited period)

Depression in primary care: part 2—management

 

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Use of vitamin D drops leading to kidney failure in a 54-year-old man – Canadian Medical Association Journal (free)

“Vitamin D toxicity is rare, but clinicians must be aware of the risks of vitamin D use to limit complications related to hypercalcemia”.

 


Review article: treatment options for functional dyspepsia – Alimentary Pharmacology and Therapeutics (free)

“None of the available therapies is effective in the majority of patients without being associated with major side effects.”

 


Ann Robinson’s weekly research reviews, 2 April 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


In-Hospital Cardiac Arrest: A Review

28 Mar, 2019 | 07:31h | UTC

In-Hospital Cardiac Arrest: A Review – JAMA (free for a limited period)

 


Alex Nowbar’s research reviews, 26 March 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Thyrotoxicosis: Diagnosis and Management

26 Mar, 2019 | 01:43h | UTC

A Clinical Overview of Off-label Use of Gabapentinoid Drugs – JAMA Internal Medicine (free for a limited period)

Related Meta-Analysis: Anticonvulsants in the Treatment of Low Back Pain and Lumbar Radicular Pain (free study and commentaries)

“Clinicians who prescribe gabapentinoids off-label for pain should be aware of the limited evidence and should acknowledge to patients that potential benefits are uncertain for most off-label uses.”

 


Why you should be a “medical conservative” – Lown Institute (free)

Original Article: Perspective: The Case for Being a Medical Conservative (free article and twitter thread)

“being a medical conservative means being skeptical about new medical advances until unbiased and high-quality evidence shows a clear benefit”

 


Schedules for Self-monitoring Blood Pressure: A Systematic Review – American Journal of Hypertension (free)

Home blood pressure should be measured for 3 days, increased to 7 only when mean blood pressure is close to a diagnostic or treatment threshold.”

 


Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis – Blood Advances (free)

Our findings indicate that patients on VKA therapy who have an INR between 4.5 and 10.0 without bleeding are not likely to benefit from vitamin K administration in addition to temporary VKA cessation.”

 


Presented at the European Heart Rhythm Association 2019 Congress.

Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation – New England Journal of Medicine (free for a limited period)

Editorial: The RACE to Treat Atrial Fibrillation in the Emergency Department (free for a limited period)

Commentary: For Acute A-fib, Wait-and-See Approach May Spare Many Patients from Cardioversion – TCTMD (free)

 

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Guidelines for Antibiotic Prescription in Intensive Care Unit – Indian Journal of Critical Care Medicine (free PDF)

Source: Critical Care Reviews Newsletter

Comprehensive guideline covering many common conditions in the Critical Care Unit.

 


Presented at the American College of Cardiology (ACC) 2019 Scientific Session.

Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial – JAMA (free for a limited period)

Related Study: Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial – JAMA (free for a limited period)

Video Summary: Catheter Ablation vs Drug Therapy for Patients With Atrial Fibrillation: The CABANA Trial (free)

Editorial: Catheter Ablation for Atrial Fibrillation: Lessons Learned From CABANA (free for a limited period)

Commentary: Surgery no better than medication at preventing serious complications of atrial fibrillation – NIH News Releases (free)

 

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Presented at the American College of Cardiology (ACC) 2019 Scientific Session.

Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients – New England Journal of Medicine (free for a limited period)

Commentary: In study, TAVR is superior to surgery for low-risk patients with aortic valve stenosis – Columbia University Irving Medical Center (free)

“”The main limitation of the study is that the current results reflect outcomes after one year, which isn’t long enough to assess the long-term durability of the replacement valve,” said Leon. “Patients in the study will be followed for at least 10 years so that we can measure their long-term outcomes and inform the medical community.” (from Columbia University)

 


Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality – JAMA (free for a limited period)

Commentaries: Are Eggs Good Or Bad? How You Should Interpret This Latest Study – Forbes (free) AND Are eggs good or bad for you? New research rekindles the debate – STAT (free) AND Eggs are bad – then good – then bad again? What gives? – Diet Doctor (free)

 

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Evidence evolving on aspirin as prevention – ACP Internist (free)

Related: Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease (link to abstract and commentaries) AND Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes (link to abstract and commentaries) AND Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly (link to abstract and commentaries) AND Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events (link to abstract and commentaries)

“In patients who have not had a prior cardiovascular event, aspirin’s protective effects are modest and may not necessarily outweigh its potential downsides (namely, risk of bleeding and hemorrhagic stroke).”

 


Signs and Symptoms That Rule out Community-Acquired Pneumonia in Outpatient Adults: A Systematic Review and Meta-Analysis – Journal of the American Board of Family Medicine (free)

Adults with an acute respiratory infection who have normal vital signs (temperature < 37,8 / respiratory rate < 20 / heart rate < 100) and a normal pulmonary examination are very unlikely to have CAP.

 


Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults – JAMA (free for a limited period)

“This Viewpoint discusses the 2018 ACC/AHA cholesterol management guideline recommendation to consider statin treatment in adults aged >75 years with LDL levels 70-189 mg/dL, arguing that trial evidence does not support it…”

 


Christopher Martyn’s research reviews, 11 March 2019 – The BMJ Opinion (free)

Christopher Martyn reviews the latest research from the top medical journals.

 


The war on ‘prediabetes’ could be a boon for pharma—but is it good medicine? – Science (free)

 

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Review: Glucose Control in the ICU

6 Mar, 2019 | 01:27h | UTC

Ann Robinson’s research reviews, 5 March 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Higher versus lower doses of ACE inhibitors, angiotensin-2 receptor blockers and beta-blockers in heart failure with reduced ejection fraction: Systematic review and meta-analysis – PLOS One (free)

 

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Paracetamol versus placebo for knee and hip osteoarthritis – Cochrane Library (free)

Summary: Paracetamol for treating people with hip or knee osteoarthritis – Cochrane Library (free)

Related: Paracetamol: widely used and largely ineffective (free)

 

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