Free Online Course: Bacteria and Chronic Infections

21Aug
2017

Study: association of obesity and metabolic health with coronary heart disease

21Aug
2017

Guideline: Safe Medication Use in the ICU

21Aug
2017

Meta-analysis: Acute Kidney Injury After Computed Tomography

21Aug
2017

Acute Kidney Injury After Computed Tomography: A Meta-analysis – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary: When kidneys are injured, CT contrast isn’t the culprit – Health Imaging (free)

Related article: Risk of Acute Kidney Injury After Intravenous Contrast Media Administration – Annals of Emergency Medicine (free)

Source: Hospital Medicine Virtual Journal Club

Compared with noncontrast CT, contrast-enhanced CT was not significantly associated with either acute kidney injury, need for renal replacement therapy, or all-cause mortality.

 

Review: Postoperative pulmonary complications

21Aug
2017

Too much medicine: Mapping the drivers of overdiagnosis to potential solutions

17Aug
2017

Standard of Care in Critically Ill Adult Patients With Atypical Hemolytic Uremic Syndrome

17Aug
2017

Decompensated Heart Failure

17Aug
2017

Comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients

17Aug
2017

A comparison of early versus late initiation of renal replacement therapy for acute kidney injury in critically ill patients: an updated systematic review and meta-analysis of randomized controlled trials – BMC Nephrology (free)

Source: Critical Care Reviews Newsletter

Early initiation of RRT in critically ill patients did not result in reduced mortality, change in renal function recovery, dependence, duration of RRT, renal recovery time, mechanical ventilation time or complications.

 

Cardiac Toxicity Of Cancer Chemotherapy

17Aug
2017

Stop Treating 70- and 90-Year-Olds the Same

17Aug
2017

Recommendations for HIV Screening of Gay, Bisexual, and Other Men Who Have Sex with Men

17Aug
2017

Recommendations for HIV Screening of Gay, Bisexual, and Other Men Who Have Sex with Men — United States, 2017 – CDC, MMWR (free)

@CDC_HIVAIDS recommends men who have sex with men be tested for HIV at least annually”. (RT @CDCMMWR see Tweet)

 

A National Implementation Project to Prevent Catheter-Associated Urinary Tract Infection in Nursing Home Residents

17Aug
2017

The role of bariatric surgery to treat diabetes

17Aug
2017

Five-Year Outcomes after On-Pump and Off-Pump Coronary-Artery Bypass

16Aug
2017

Benefits and safety of gabapentinoids in chronic low back pain

16Aug
2017

Effect of scheduled second-look endoscopy on peptic ulcer bleeding

16Aug
2017

Effect of scheduled second-look endoscopy on peptic ulcer bleeding: a prospective randomized multicenter trial – Gastrointestinal Endoscopy (link to abstract – $ for full-text)

Source: No Benefit of Second-Look Endoscopy After Endoscopic Hemostasis – Journal Watch ($)

“A single EGD with endoscopic hemostasis is not inferior to scheduled second-look endoscopy in terms of reduction in rebleeding rate of peptic ulcer bleeding. Repeat endoscopy would be helpful in the patients with unsatisfactory initial endoscopic hemostasis, use of NSAIDs, and larger amounts of transfused blood”

 

Role of nutrition support in adult cardiac surgery

16Aug
2017

Syphilis in the ED: Presentations, Diagnosis, and Management of the Great Imitator

16Aug
2017

Working up high: Hospitalist practice is different at altitude

16Aug
2017

An order not to hospitalize

16Aug
2017

Epilepsy ‘Not a Rare Condition’

16Aug
2017

Study: diet soda can really mess with your metabolism

16Aug
2017

Study: diet soda can really mess with your metabolism – VOX (free)

Original article: Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward – Current Biology (link to abstract – $ for full-text)

See also a related meta-analysis showing little evidence of artificial sweeteners for weight loss in our July 18th issue (see #2)

“New research helps explain why artificial sweeteners are linked to obesity and metabolic disease”.

 

Occupation and Risk of Developing Rheumatoid Arthritis

16Aug
2017

FDA Safety Alert: Liquid-filled Intragastric Balloon Systems

16Aug
2017

Standards for Diabetes Self-management Education and Support

16Aug
2017

Special issue: 60 years of metformin use

16Aug
2017

SGLT2 agents may reduce cardiovascular risk in diabetics

16Aug
2017

Relationship of Alcohol Consumption to All-Cause, Cardiovascular, and Cancer-Related Mortality

15Aug
2017

The Effects of Cannabis Among Adults With Chronic Pain

15Aug
2017

Foot care for people with diabetes: prevention of complications and treatment

15Aug
2017

The 10-Year Prognostic Value of Zero and Minimal CAC

15Aug
2017

The 10-Year Prognostic Value of Zero and Minimal CAC – Journal of The American College of Cardiology (no abstract – $ for full text)

Commentary: Calcium in Arteries Influences Heart Attack Risk –  UT Southwestern Medical Center, via NewsWise (free) AND Study: Calcium in arteries influences heart attack risk – UPI (free)

“Half of the participants had no calcium deposits in their arteries or a zero coronary artery calcium, or CAC, score, and had less than a 3 percent chance of a cardiovascular event over a 10-year period despite having other risk factors for heart disease and stroke such as type 2 diabetes, high blood pressure and high bad cholesterol levels” (from UPI)

 

Risk traumatic brain injuries associated with antidepressant use among patients with Alzheimer’s disease

15Aug
2017

Blood pressure targets for hypertension in older adults

15Aug
2017

Blood pressure targets for hypertension in older adults – Cochrane Library (free)

Full review: Blood pressure targets for hypertension in older adults – Cochrane Library (link to abstract – $ for full-text)

Related guideline: Pharmacologic Treatment of Hypertension in Adults Aged 60 Years or Older to Higher Versus Lower Blood Pressure Targets: A Clinical Practice Guideline From ACP and AAFP (free)

“At the present time there is insufficient evidence to know whether a higher BP target (less than150 to 160/95 to 105 mmHg) or a lower BP target (less than 140/90 mmHg) is better for older adults with high BP”

 

Longer sleep is associated with lower BMI and favorable metabolic profiles

15Aug
2017

Sepsis in the burn patient

15Aug
2017

The effect of high-flow nasal cannula in reducing the mortality and the rate of endotracheal intubation

15Aug
2017

Ibuprofen versus placebo effect on acute kidney injury in ultramarathons

15Aug
2017

Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment

15Aug
2017

Pathogenesis and management of hypoglycemia

15Aug
2017

Management of urinary tract infections in patients with neurogenic bladder

15Aug
2017

Car crashes in older adult drivers using Zolpidem

15Aug
2017

Richard Lehman’s journal review, 14 August 2017

15Aug
2017

8 – Richard Lehman’s journal review, 14 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals

 

Neurologic Complications Associated With the Zika Virus

15Aug
2017

Eliminating CK–MB Testing in Suspected Acute Coronary Syndrome

15Aug
2017

Advances in the diagnosis and management of neck pain

15Aug
2017

Midlife Vascular Risk Factors and Incident Dementia

14Aug
2017

Day-to-Day Blood Pressure Variability and Risk of Dementia

14Aug
2017

Effect of 0.5 mg versus 1 mg varenicline for smoking cessation

14Aug
2017

Effect of 0.5 mg versus 1 mg varenicline for smoking cessation: a randomized controlled trial – Addiction (link to abstract – $ for full-text)

“No difference in smoking cessation effectiveness between 1 mg and 0.5 mg twice daily varenicline” (46.5% vs 46.4%) (RT @JorgeMTamayo see Tweet)

 

Self-management interventions for patients with COPD

14Aug
2017

Self-management interventions including action plans for patients with Chronic Obstructive Pulmonary Disease (COPD) – Cochrane Library (free)

Full review: Self-management interventions including action plans for exacerbations versus usual care in patients with chronic obstructive pulmonary disease (link to summary – $ for full-text)

Related: Asthma self-management programmes can reduce unscheduled care – NIHR Signal (free)

Self-management interventions that include a COPD exacerbation action plan are associated with improvements in health-related quality of life and lower probability of respiratory-related hospital admissions.

 

Risk of Stroke With Various Types of Menopausal Hormone Therapies

14Aug
2017

Risk of Stroke With Various Types of Menopausal Hormone Therapies: A National Cohort Study – Stroke (link to abstract – $ for full-text)

Source: EvidenceAlerts

This large cohort confirms an increased stroke risk with oral hormone therapies, but suggests no increased risk of stroke with transdermal or vaginal estrogen application.

 

Asthma-Chronic obstructive pulmonary disease overlap syndrome

14Aug
2017

Review: Lyme Disease: Emergency Department Considerations

11Aug
2017

Review: General Care of the Pregnant Patient in the Intensive Care Unit

11Aug
2017

Review: Palliative and end-of-life care in nephrology

11Aug
2017

Lifestyle Risk Factors Increase the Risk of Hospitalization for Sciatica

11Aug
2017

Review: My Treatment Approach to Gout

11Aug
2017

Lithium Associated With a Higher Risk of Chronic Kidney Disease in Older Adults

11Aug
2017

Lithium Use, but Not Valproate Use, Is Associated With a Higher Risk of Chronic Kidney Disease in Older Adults With Mental Illness – The Journal of Clinical Psychiatry (link to abstract -$ for full-text)

Case-control study suggests Lithium is associated with increased risk of chronic kidney disease.

 

Duration of Dual Antiplatelet Therapy in Patients with an Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention

11Aug
2017

Aspirin Does Not Increase Heart Failure Events in Heart Failure Patients

11Aug
2017

Addressing Alcohol Use Practice Manual: An Alcohol Screening and Brief Intervention Program

11Aug
2017

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients

11Aug
2017

Mechanical Thrombectomy Outcomes With and Without Intravenous Thrombolysis in Stroke Patients: A Meta-Analysis – Stroke (link to abstract – $ for full-text)

Commentary: Better outcomes seen in patients who received IV thrombolysis before thrombectomy – ACP Hospitalist (free)

“The results support current guideline recommendations to give intravenous thrombolysis to eligible patients even if they are being considered for mechanical thrombectomy, according to the meta-analysis authors” (from ACP)

 

Anticoagulation for stroke prevention in very elderly patients with atrial fibrillation

11Aug
2017

Diarrhea after bariatric procedures: Diagnosis and therapy

11Aug
2017

Gout: An old disease in new perspective

11Aug
2017

Epidemiology, pathophysiology, and management of uric acid urolithiasis

11Aug
2017

Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy

11Aug
2017

Procalcitonin: a promising diagnostic marker for sepsis and antibiotic therapy – Journal of Intensive Care (free)

“it is unlikely that a single biomarker serve as an effective diagnosis tool”

 

Seasonal influenza: managing cases in critical care units

11Aug
2017

Depression and risk of death following coronary artery disease diagnosis

10Aug
2017

Nephrolithiasis more common in patients with gout

10Aug
2017

Incidence of and risk factors for nephrolithiasis in patients with gout and the general population, a cohort study – Arthritis Research & Therapy (free)

Commentaries: Gout Patients Run Higher Risk of Kidney Stones – MedPage Today (free registration required) AND Gout associated with elevated risk for kidney stones – MedWire News (free)

“60% increased risk of first-time nephrolithiasis versus general population, with little protection from allopurinol” (from MedPage Today)

 

Interventions for emergency contraception

10Aug
2017

On-demand pre-exposure prophylaxis for HIV

10Aug
2017

Efficacy, safety, and effect on sexual behaviour of on-demand pre-exposure prophylaxis for HIV in men who have sex with men: an observational cohort study – The Lancet HIV (free registration required)

Commentaries: PrEP on demand or every day? – The Lancet HIV (free registration required) AND HIV pre-exposure prophylaxis can be taken as needed – Reuters (free)

“four doses of PrEP around the time of sexual activity cut the risk of HIV by 97 percent” (from Reuters Health)

 

Effects of CPAP and Mandibular Advancement Devices on Quality of Life in Sleep Apnea

10Aug
2017

Effects of CPAP and Mandibular Advancement Devices on Health-Related Quality of Life in OSA – Chest (free)

See also a recent study showing CPAP does not reduce cardiovascular events in our July 13th issue (see #2)

“CPAP is effective in improving health-related quality of life in OSA, and Mandibular Advancement Devices may be just as effective, but further RCTs comparing the two treatments are required”.

 

Strategies to prevent death by suicide

10Aug
2017

Suicide Prevention in an Emergency Department Population

10Aug
2017

Suicide Prevention in an Emergency Department Population: The ED-SAFE Study – JAMA Psychiatry (link to abstract – Free Full Text PDF via @unpaywall)

Commentaries: Intervention Phone Calls May Save The Lives Of Suicidal Patients, Reduce New Attempts, Trial Finds – Medical Daily (free) AND National study shows interventions like telephone calls can reduce suicides – EurekAlert (free) AND Intervention Curbs New Suicide Attempts in At-Risk ED Patients – Medscape (free registration required)

Source: Psychiatry Research Review

“Patients who received a multifaceted intervention that included follow-up telephone calls resulted in a 30 percent reduction in future suicide attempts” (from Medical Daily)

 

Diet and Risk of Cholecystectomy

10Aug
2017

Neuroprotective Diets Are Associated with Better Cognitive Function

10Aug
2017

Challenges in Treating Cardiovascular Disease: Restricting Sodium and Managing Hyperkalemia

10Aug
2017

Antibiotic prophylaxis is not indicated prior to dental procedures for prevention of periprosthetic joint infections

10Aug
2017

Surgical Guidelines for Perioperative Management of Older Adults

10Aug
2017

Functional Gain and Pain Relief After Total Joint Replacement According to Obesity Status

10Aug
2017

Effects of CPAP and Mandibular Advancement Devices on Health-Related Quality of Life in OSA

10Aug
2017

Effects of CPAP and Mandibular Advancement Devices on Health-Related Quality of Life in OSA – Chest (free)

See also a recent study showing CPAP does not reduce cardiovascular events in our July 13th issue (see #2)

“CPAP is effective in improving health-related quality of life in OSA, and Mandibular Advancement Devices may be just as effective, but further RCTs comparing the two treatments are required”.

 

Continuous glucose monitoring in the ICU: clinical considerations and consensus

10Aug
2017

What do hypnotics cost hospitals and healthcare?

10Aug
2017

What do hypnotics cost hospitals and healthcare? – F1000 Research (free)

Source: Hospital Medicine Virtual Journal Club

“A best estimate is that U.S. costs of hypnotic harms to healthcare systems are on the order of $55 billion, but conceivably might be as low as $10 billion or as high as $100 billion”.

 

Effect of marijuana use on cardiovascular and cerebrovascular mortality

10Aug
2017

Alternatives to hospital admission for people aged over 65 years

9Aug
2017

A systematic review to identify and assess the effectiveness of alternatives for people over the age of 65 who are at risk of potentially avoidable hospital admission – BMJ Open (free) (RT @NIHR_DC)

Alternatives to hospital admission for people aged over 65 years can be safe and reduce costs across a range of acute and chronic conditions.

 

Treating subclinical thyroid dysfunction in pregnancy probably has no benefit

9Aug
2017

How long should I take antibiotics?

9Aug
2017

Association of Estimated Sodium Intake With Adverse Cardiac Structure and Function

9Aug
2017

How Low Is Too Low With Salt in Heart Failure?

9Aug
2017

Clinical management of hypercholesterolaemia in patients with acute coronary syndromes

9Aug
2017

Acute mesenteric ischemia: guidelines

9Aug
2017

Severe infections and subsequent delayed cardiovascular disease

9Aug
2017

Guideline: Induction therapy of ANCA-associated vasculitis

9Aug
2017

Subclinical thyrotoxicosis: prevalence, causes and choice of therapy

7Aug
2017

Richard Lehman’s journal review, 7 August 2017

7Aug
2017

Richard Lehman’s journal review, 7 August 2017 – The BMJ Blogs (free)

Richard Lehman reviews the latest research in the top medical journals.

 

Raw milk and cheese cause 840 times more illnesses than pasteurized products

7Aug
2017

Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome

7Aug
2017

Optimal timing of an invasive strategy in patients with non-ST-elevation acute coronary syndrome: a meta-analysis of randomised trials – The Lancet (link to abstract – $ for full-text)

Commentary: Optimal Timing of an Invasive Strategy in NSTE-ACS Patients – American College of Cardiology, Latest in Cardiology (free)

An early invasive strategy does not reduce mortality compared with a delayed invasive strategy in most patients with NSTE-ACS, but seems to reduce mortality in high-risk patients.

 

Long-term follow-up of patients with pulmonary thromboembolism

7Aug
2017

Guideline: stroke prevention in atrial fibrillation

7Aug
2017
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