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Open access

NEWS - Internal Medicine

Focus on randomised clinical trials – Intensive Care Medicine (free PDF) (via @CritCareReviews)

Related: What should we stop doing in the ICU? – ICU Management & Practice (free)

“Their results add to what appears to be a constant theme in critical care, ‘less is more’ based on RCT results”

 


Alex Nowbar’s weekly research reviews, 3 December 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Why Hospitals Should Let You Sleep – The New York Times (10 articles per month are free)

“Frequent disruptions are more than just annoying for patients. They can also cause harm.”

 


Medical Screening Tests You Do and Don’t Need – Consumer Reports (free) (via @EricTopol)

“Some may be life-saving, but others can waste time and money—and pose risks”

 


Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis – International Journal of Cardiology (free)

“…current fluoroquinolone use was significantly associated with increased risk of aortic aneurysm and dissection.”

 


Ann Robinson’s research reviews, 26 November 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Cannabinoids for Chronic Pain – Therapeutics Initiative (free)

Related: Meta-Analysis: Cannabinoids for the Treatment of Chronic Noncancer Pain Conditions (free) AND Guideline for Prescribing Medical Cannabinoids in Primary Care (free article and commentary)

“At the present time we lack good evidence that any cannabis-derived product works for chronic pain”

 


Abraar Karan: Has the physical exam had its day? – The BMJ Opinion (free)

“Seeing patients in clinic today, I know that putting my stethoscope on them has a therapeutic effect, even if as their doctor, I am quite certain their heart and lungs are normal. However, this doesn’t mean the physical exam should not evolve.” (via @AbraarKaran see Tweet)

 


Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS – New England Journal of Medicine (free)

“Prednisone treatment during the first 4 weeks after the initiation of ART for HIV infection resulted in a lower incidence of tuberculosis-associated immune reconstitution inflammatory syndrome than placebo, without evidence of an increased risk of severe infections or cancers.”

 


Antipsychotic drug use and pneumonia: Systematic review and meta-analysis – Journal of Psychopharmacology (link to abstract – $ for full-text)

Commentary: Antipsychotics May Increase Risk of Pneumonia, Meta-Analysis Suggests – Psychiatric News Alert (free)

“Although antipsychotic use was associated with a higher risk of pneumonia, the researchers stopped short of claiming causality, citing a lack of data from randomized, controlled trials and a failure of observational studies to control for relevant confounders like tobacco use and weight.” (from Psychiatric News Alert)

 


Alex Nowbar’s research reviews, 12 November 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Risk of Malignant Ovarian Cancer Based on Ultrasonography Findings in a Large Unselected Population – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Most simple ovarian cysts require no treatment, surveillance – UPI (free) AND Less surveillance needed for simple ovarian cysts – University of California, San Francisco (free)

“New study finds that simple cysts should be considered normal and ignored” (from The University of California)

 


Perioperative alcohol cessation intervention for postoperative complications – Cochrane Library (free)

Summary: Effects of perioperative alcohol cessation interventions on postoperative complications following surgery – Cochrane Library (free)

“Intensive alcohol cessation interventions offered for four to eight weeks to participants undergoing all types of surgical procedures to achieve complete alcohol cessation before surgery probably reduced the number of postoperative complications.”

 


A Profusion of Diagnoses. That’s Good and Bad – The New York Times (10 articles per month are free)

“…we may also be medicalizing much of normal human behavior — labeling the healthy as diseased, and exposing them to undue risk of stigma, testing and treatment.”

 


Graduated compression stockings for prevention of deep vein thrombosis – Cochrane Library (free)

Summary: Graduated compression stockings for prevention of deep vein thrombosis during a hospital stay – Cochrane Library (free)

“There is high-quality evidence that GCS are effective in reducing the risk of DVT in hospitalised patients who have undergone general and orthopaedic surgery”

 


Ann Robinson’s weekly research reviews, 5 November 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

Summary: Preventative antibiotic therapy for people with COPD – Cochrane Library (free)

“Use of continuous and intermittent prophylactic antibiotics results in a clinically significant benefit in reducing exacerbations in COPD patients.”

 



Alex Nowbar’s research reviews, 29 October 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Intravenous Iron in Patients Undergoing Maintenance Hemodialysis – New England Journal of Medicine (free)

“Proactive administration of high-dose iv iron did not adversely affect mortality or CV events, but enabled reduced erythropoiesis-stimulating agent dosing and transfusion rates.” (via @NatRevNeph see Tweet)

 


Early enteral nutrition within 24 hours of lower gastrointestinal surgery versus later commencement for length of hospital stay and postoperative complications – Cochrane Library (free)

Summary: The effect of having nutrition within the first 24 hours after bowel surgery on length of hospital stay and postoperative complications – Cochrane Library (free)

This review suggests that early enteral feeding is associated with a shorter length of hospital stay. For all other outcomes (postoperative complications, mortality, adverse events, and QoL) the findings are inconclusive.

 


Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis – The BMJ (free)

“Using the adjuvant recombinant subunit vaccine might prevent more cases of herpes zoster than using the live attenuated vaccine, but the adjuvant recombinant subunit vaccine also carries a greater risk of adverse events at injection sites.”

 


Pantoprazole in Patients at Risk for Gastrointestinal Bleeding in the ICU – New England Journal of Medicine (free for a limited period)

Editorial: Proton-Pump Inhibitor Prophylaxis in the ICU — Benefits Worth the Risks? (free for a limited period)

“Proton pump inhibitors are minimally effective to reduce GI bleeding among the critically ill folks at high risk for stress ulcers. Takeaways: no role for routine PPI for any patients on the WARDS, and shouldn’t be considered ‘routine’ in the ICU” (via @AnilMakam see Tweet)

 


Association of Blood Pressure Measurements With Peripheral Artery Disease Events: Reanalysis of the ALLHAT Data – Circulation (free)

Editorial: New Curveball for Hypertension Guidelines? Blood Pressure Targets in Peripheral Artery Disease (free)

“we found a higher rate of lower extremity PAD events with higher and lower SBP and pulse pressure and with lower DBP.”

 


The Problem With Probiotics – The New York Times (free)

Related: Probiotic Safety—No Guarantees (free perspective)

“There are potential harms as well as benefits, and a lot of wishful thinking and imprecision in the marketing of products containing them.”

 


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