Or

Open access

Internal Medicine / Hospital Medicine


Efficacy and safety of stress ulcer prophylaxis in critically ill patients: a network meta-analysis of randomized trials – Intensive Care Medicine (free)

“PPIs are the most effective agents in preventing CIB, but they may increase the risk of pneumonia”.

 


Does Cancer Screening Save More Lives Overall? Not Necessarily – WBUR (free) (via @HealthNewsRevu see Tweet)

Related systematic review: Does screening for disease save lives in asymptomatic adults? Systematic review of meta-analyses and randomized trials – International Journal of Epidemiology (free)

“We are not suggesting that cancer screening is useless. Our critique aims to show that screening tests are like any other medical intervention: there are benefits and harms.  And it’s why we support informed decision-making”.

 


Richard Lehman’s journal review, 4 December 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 27 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Aerobic exercise moderately reduces depressive symptoms in new mothers – NIHR Signal (free)

Original article: Does aerobic exercise reduce postpartum depressive symptoms? a systematic review and meta-analysis – British Journal of General Practice (free)

“Involving new mothers in group exercise programmes, or advising them on an exercise of their choice, reduced depressive symptoms compared with usual care” (RT @NIHR_DC see Tweet)

 


Low dose aspirin as adjuvant treatment for venous leg ulceration: pragmatic, randomised, double blind, placebo controlled trial (Aspirin4VLU) – The BMJ (free)

“Low dose aspirin does not increase time to healing of venous leg ulcers, percentage healed, estimated change in venous leg ulcer area, or change in health related quality of life”.

 


Prolonged Infusion Piperacillin-Tazobactam Decreases Mortality and Improves Outcomes in Severely Ill Patients: Results of a Systematic Review and Meta-Analysis – Critical Care Medicine (link to abstract – $ for full-text)

Source: ACP Journal Wise ($)

“Receipt of prolonged infusion of piperacillin-tazobactam was associated with reduced mortality and improved clinical cure rates across diverse cohorts of severely ill patients”.

 


Seven-year tolerability profile of glucocorticoids use in early rheumatoid arthritis: data from the ESPOIR cohort – Annals of Rheumatic Diseases (free)

Commentaries: Long-Term Safety of Glucocorticoids in Patients with Early Rheumatoid Arthritis – Journal Watch (free) AND Long-term Low-dose Steroids OK in Early RA – MedPage Today (free registration required)

“Long-Term Safety of Glucocorticoids in Early Rheumatoid Arthritis. Stopping steroids completely is difficult in patients whose disease flares with tapering, but low-dose levels are relatively safe” (RT @JWatch see Tweet)

 


Inappropriate Management of Asymptomatic Patients With Positive Urine Cultures: A Systematic Review and Meta-analysis – Open Forum Infectious Diseases (free)

“OFID: Despite guidelines, continued overtreatment of patients with positive urine cultures but no symptoms” (RT @IDSAInfo see Tweet)

 


Systematic Review and Meta-analysis Comparing the Efficacy of Nonsteroidal Anti-inflammatory Drugs, Opioids, and Paracetamol in the Treatment of Acute Renal Colic – European Urology (free) (via @KariTikkinen and @EUplatinum)

“In kidney stone–related acute pain episodes in patients with adequate renal function, treatment with nonsteroidal anti-inflammatory drugs offers effective and most sustained pain relief, with fewer side effects, when compared with opioids or paracetamol”.

 


Comprehensive assessment when older people are in hospital improves their chances of getting home and living independently – NIHR Signal (free)

Original article: Comprehensive geriatric assessment for older adults admitted to hospital – Cochrane Library (free summary – $ for full-text) AND News Release: Comprehensive geriatric assessment for older adults admitted to hospital (free)

“Comprehensive assessment when older people are in hospital improves their chances of getting home and living independently” (RT @NIHR_DC see Tweet)

 


Oxygen therapy for acute myocardial infarction: A systematic review and meta-analysis – International Journal of Nursing Studies (link to abstract – $ for full-text)

Source: Supplemental Oxygen Is Associated with Excess Risk for Recurrent Myocardial Infarction – Journal Watch ($)

See related article – “Oxygen Therapy in Suspected Acute Myocardial Infarction” – and commentaries in our August 29th issue (see #1)

“Supplemental Oxygen Associated w/ Excess Risk for Recurrent Myocardial Infarction. It’s time to stop the free flow of oxygen when not absolutely needed” (RT @JWatch see Tweet)

 


Richard Lehman’s journal review, 20 November 2017 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Taking Care of the Physician – The New York Times (10 articles per month are free)

 


Timing of Angiography and Outcomes in High-Risk Patients With Non–ST-Segment–Elevation Myocardial Infarction Managed Invasively – Circulation (free)

“High risk NSTEMI undergoing cath within 12 hours had lower risk of death and MI at 180 days” (RT @CircAHA see Tweet)

 


CheXNet: Radiologist-Level Pneumonia Detection on Chest X-Rays with Deep Learning – Stanford ML Group (free)

“We develop an algorithm that can detect pneumonia from chest X-rays at a level exceeding practicing radiologists”

 


Health Effects and Public Health Concerns of Energy Drink Consumption in the United States: A Mini-Review – Frontiers in Public Health (free)

Commentaries: Serious health risks associated with energy drinks – ScienceDaily (free)

“To curb this growing public health issue, policy makers should regulate sales and marketing towards children and adolescents and set upper limits on caffeine” (from ScienceDaily)

 


Association of Blood Pressure Lowering With Mortality and Cardiovascular Disease Across Blood Pressure Levels: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Treating modestly high blood pressure may not boost survival odds – Reuters (free) AND No cardiovascular disease reduction with intensive blood pressure lowering treatment – Umea University, via EurekAlert (free)

See also new AHA/ACC Hypertension Guidelines and related resources in our November 13th issue (see #1)

“”Primary preventive BP lowering is associated with reduced risk for death and CVD if baseline SBP is 140 mm Hg or higher.” published same day as @ACCinTouch guideline w/SBP goals <130 mm Hg. Cognitive dissonance?” (RT @kennylinafp see Tweet)

 


Richard Lehman’s journal review, 13 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study – The BMJ (free)

Commentary: Vitamin D level not associated with cancer risk – Clinical Adviser (free)

“These results, in combination with previous literature, provide evidence that population-wide screening for vitamin D deficiency and subsequent widespread vitamin D supplementation should not currently be recommended as a strategy for primary cancer prevention”.

 


Debate: the case for and against screening for breast cancer with mammography

The case for mammography: Routine mammograms do save lives: The Science – The Conversation (free)

The case against mammography: Routine mammograms do not save lives: The research is clear – The Conversation (free)

Related: Make Screening Mammography Personal, Say the French – Medscape (free registration required)

“The debate over breast cancer screening continues, with disagreements about the start age, frequency, mortality effect, overdiagnosis, and overtreatment” (from Medscape)

 


Richard Lehman’s journal reviews, 6 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Association of Warfarin Use With Lower Overall Cancer Incidence Among Patients Older Than 50 Years – JAMA Internal Medicine (free)

“In this population-based cohort study of 1.256.725 persons, there was a significantly lower age- and sex-adjusted incidence rate ratio of cancer among warfarin users vs nonusers”.

 


Glucocorticosteroids for people with alcoholic hepatitis – Cochrane Library (free)

Original article: Glucocorticosteroids for people with alcoholic hepatitis – Cochrane Library (link to abstract – $ for full-text)

“We found no evidence of a difference between glucocorticosteroids and placebo or no intervention on all-cause mortality, health-related quality of life, and serious adverse events during treatment”.

 


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