Internal Medicine

Effectiveness of management strategies for uninvestigated dyspepsia: systematic review and network meta-analysis – The BMJ (free)

Commentary: Managing Dyspepsia with “Test and Treat” Ranked Best Strategy – NEJM Journal Watch (free)

 

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Homepage: CPR Guidelines (free summaries and infographics)

– 2019 Highlights – Guidelines Update for CPR & ECC

– 2019 FAQ – Guidelines Update for CPR & ECC

– 2019 Infographic – ACLS Guidelines Update

– 2019 Infographic – PALS Guidelines Update

Original Guidelines: AHA Updates on Advanced Cardiovascular Life Support (ACLS) (free) AND AHA Updates in Pediatric Life Support (free)

 

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The Ketogenic Diet: Pros and Cons

9 Dec, 2019 | 01:30h | UTC

NICE Guideline: Menopause

6 Dec, 2019 | 10:50h | UTC

Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial – JAMA (free for a limited period)

 

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Ann Robinson’s research reviews, 5 December 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals

 


ASH Guideline: Immune Thrombocytopenia

5 Dec, 2019 | 11:19h | UTC

The effect of remote ischaemic preconditioning on myocardial injury in emergency hip fracture surgery (PIXIE trial): phase II randomised clinical trial – The BMJ (free)

Related Perspective: Remote ischaemic preconditioning: an intervention for anaesthetists? – British Journal of Anaesthesia (free)

 

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Review: Celiac Disease

4 Dec, 2019 | 08:20h | UTC

Management of severe acute pancreatitis – The BMJ (free for a limited period)

Related Guidelines: 2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery (free) AND American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis (free) AND Pancreatitis – National Institute for Health and Care Excellence (free) AND American College of Gastroenterology Guideline: Management of Acute Pancreatitis (free)

 

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Supplemental MRI Screening for Women with Extremely Dense Breast Tissue – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Does MRI Screening Benefit Women With Extremely Dense Breasts? – U.S. News (free) AND Mixed Results With Mammo Plus MRI Screening – MedPage Today (free)

“The benefits need to be carefully weighed against the harms, as MRI examination is more expensive, and it requires the injection of a contrast agent into the body. MRI will also detect abnormalities that later turn out not to be breast cancer after all” (from U.S News)

 

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Podcast: Update in Sleep Medicine

27 Nov, 2019 | 08:08h | UTC

Iron Deficiency Anemia Revisited

26 Nov, 2019 | 07:35h | UTC

Evaluating a digital sepsis alert in a London multisite hospital network: a natural experiment using electronic health record data – Journal of the American Medical Informatics Association (free)

Commentary: Digital monitoring system helps improve hospital care of sepsis patients – OnMedica (free) AND Sepsis digital alert ‘led to faster treatment with antibiotics’ – BBC (free)

 

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A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Treat Stroke to Target Finds Lower Risk of CV Events With Lower LDL-C Levels – American College of Cardiology (free) AND Treat Stroke to Target – Treat Stroke to Target – American College of Cardiology (free) AND Lower Cholesterol Cuts CV Events: Treat Stroke to Target Trial – TCTMD (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Coronary Microvascular Dysfunction Causing Cardiac Ischemia in Women – JAMA (free for a limited period)

Related: Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries (study, guidelines, and reviews on the subject)

 

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Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Colchicine Cardiovascular Outcomes Trial – COLCOT – American College of Cardiology (free) AND COLCOT Renews Hope for Anti-inflammatory in Secondary Prevention: Colchicine – TCTMD (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Outcomes at follow-up of negative colonoscopy in average risk population: systematic review and meta-analysis – The BMJ (free)

Related Guidelines: ACP Guideline: Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults (free) AND BMJ Guideline: Colorectal Cancer Screening with Fecal Immunochemical Testing, Sigmoidoscopy or Colonoscopy (new guideline suggesting a more selective approach to screening) AND Colorectal cancer screening for average‐risk adults: 2018 guideline update from the American Cancer Society (recent guideline with recommendation to start screening at 45 years, with links to guidelines from other organizations)

“Our findings suggest that 10 year intervals for colonoscopy screening after a negative colonoscopy, as currently recommended, may be adequate”

 


Alex Nowbar’s weekly review, 15 November 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: What Can We Learn From The Apple Heart Study? – Cardiobrief (free)

“…nearly half a million people were required to identify a few hundred people with AF. (It should further be noted that we have no idea whether the patients identified in this group will even benefit from their diagnosis, since they may differ in important ways from AF patients identified by traditional means.)” (from Cardiobrief)

 


Association of Testosterone Therapy With Risk of Venous Thromboembolism Among Men With and Without Hypogonadism – JAMA Internal Medicine (free for a limited period)

 

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Development of Risk Prediction Equations for Incident Chronic Kidney Disease – JAMA (free for a limited period)

See Calculator: Risk of Developing Reduced Kidney Function (free tool)

Editorial: Predicting Risk of Kidney Disease: Is Risk-Based Kidney Care on the Horizon? – JAMA (free for a limited period)

Commentaries: New Tool Predicts Five-Year Risk of Chronic Kidney Disease With High Accuracy – Johns Hopkins Bloomberg School of Public Health (free) AND Researchers Develop Tool to Identify Those at Risk of Future CKD – AJMC (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

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Effect of Vitamin D and Omega-3 Fatty Acid Supplementation on Kidney Function in Patients With Type 2 Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Vitamin D and Health Outcomes: Then Came the Randomized Clinical Trials – JAMA (free for a limited period)

Commentary: Supplements don’t preserve kidney health in Type 2 diabetes – University of Washington School of Medicine (free)

#KidneyWk – Just presented at the American Society of Nephrology Kidney Week 2019

 

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Podcast: Management of Multimorbidity

10 Nov, 2019 | 13:55h | UTC

UPDATE: The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication – U.S Food and Drug Administration (free)

Commentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)

“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”

 


Randomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)

Source: EvidenceAlerts

“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”

 


Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients – Nature Medicine (link to abstract – $ for full-text)

Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)

 

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Ann Robinson’s journal review, 7 November 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Association between gifts from pharmaceutical companies to French general practitioners and their drug prescribing patterns in 2016: retrospective study using the French Transparency in Healthcare and National Health Data System databases – The BMJ (free)

 

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Update on the Management of Constipation – JAMA (free for a limited period)

Related: Indian Consensus on Chronic Constipation in Adults (free guidelines and reviews on the subject)

 


Benefits and harms of intensive glycemic control in patients with type 2 diabetes – The BMJ (free for a limited period)

 

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Which specific modes of exercise training are most effective for treating low back pain? Network meta-analysis – British Journal of Sports Medicine (free)

 

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Open-label randomised pragmatic trial (CONTACT) comparing naproxen and low-dose colchicine for the treatment of gout flares in primary care – Annals of Rheumatic Diseases (free)

 

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Alex Nowbar’s weekly review, 1 November 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA (free for a limited period)

Editorial: The Thyrotropin Reference Range Should Be Changed in Older Patients (free for a limited period)

Related Review: Subclinical Hypothyroidism – JAMA (free for a limited period)

Related Randomized Trial: Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine (free)

 

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A comprehensive analysis of mortality-related health metrics associated with mental disorders: a nationwide, register-based cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: Life expectancy mapped for people with mental disorders – The University of Queensland (free) AND Mentally ill die many years earlier than others – Aarhus University (free)

 

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Sepsis hysteria: excess hype and unrealistic expectations – The Lancet (free)

Commentary: Sepsis myths create ‘unhealthy climate of fear’, say experts – The Guardian (free)

Source: Grupo UTIclínica – HCFMUSP

 

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Is Mycobacterium tuberculosis infection life long? – The BMJ (free)

Commentaries: Tuberculous infection is not life-long in most people – University of Pennsylvania School of Medicine (free) AND In the absence of a true test for latent TB we need shorter, safer preventive treatments – The BMJ Opinion (free)

 

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Trends in Internet Searches for Cannabidiol (CBD) in the United States – JAMA Network Open (free)

Commentaries: Interest in CBD products keeps soaring, but health experts wary – HealthDay (free) AND Online Searches For CBD Skyrocket – MedicalResearch.com (free)

 

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The Silent Heart Attack You Didn’t Know You Had – The New York Times (10 articles per month are free)

Related Studies: Silent Myocardial Infarction Often Precedes Sudden Cardiac Death (link to abstract and commentaries) AND Cohort Study: Long-term Outcomes of Unrecognized MI (link to abstract and commentaries)

 


Ann Robinson’s journal review, 23 October 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.