Internal Medicine

Chloroquine and hydroxychloroquine in covid-19 – Tue BMJ

“Use of these drugs is premature and potentially harmful.”

 


[Preprint] Population-level COVID-19 mortality risk for non-elderly individuals overall and for non-elderly individuals without underlying diseases in pandemic epicenters – medRxiv

“CONCLUSIONS: People <65 years old have very small risks of COVID-19 death even in the hotbeds of the pandemic and deaths for people <65 years without underlying predisposing conditions are remarkably uncommon. Strategies focusing specifically on protecting high-risk elderly individuals should be considered in managing the pandemic.”

Related perspectives from the same author:

Video: Perspectives on the Pandemic with Dr. John Ioannidis

Podcast: Be it resolved, we are making high-stakes decisions about the COVID-19 pandemic without reliable data. – Munk Debates Podcast

Editorial: Coronavirus disease 2019: the harms of exaggerated information and non‐evidence‐based measures – European Journal of Clinical Investigation

Opinion Piece: A fiasco in the making? As the coronavirus pandemic takes hold, we are making decisions without reliable data – STAT

 


PCR Assays Turned Positive in 25 Discharged COVID-19 Patients – Clinical Infectious Diseases

 

Related Commentary on Twitter

 


Editorials: Covid-19 Testing Times

9 Apr, 2020 | 03:26h | UTC

Taking Care of COVID-19 Survivors

9 Apr, 2020 | 03:17h | UTC

Video: COVID-19 Clinical Update

8 Apr, 2020 | 01:35h | UTC

2019 Update of the Joint European League Against Rheumatism and European Renal Association–European Dialysis and Transplant Association (EULAR/ERA–EDTA) recommendations for the management of lupus nephritis – Annals of Rheumatic Diseases

Commentary: EULAR, ERA–EDTA issue guidelines for managing lupus nephritis – Medicine Matters

Related Guidelines: Consensus of the Brazilian Society of Rheumatology for the diagnosis, management and treatment of lupus nephritis (free) AND 2019 European League Against Rheumatism/American College of Rheumatology Classification Criteria for Systemic Lupus Erythematosus (free) AND 2019 update of the EULAR recommendations for the management of systemic lupus erythematosus (free) AND Clinical Practice Guidelines for the Treatment of Systemic Lupus Erythematosus by the Mexican College of Rheumatology (free) AND The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus (free) AND Canadian Rheumatology Association Recommendations for the Assessment and Monitoring of Systemic Lupus Erythematosus (free PDF)

Related Reviews: Update on Lupus Nephritis – Clinical Journal of the American Society of Nephrology (free) AND Immunosuppressive Treatment for Proliferative Lupus Nephritis – Cochrane Library (free) AND Induction and Maintenance Immunosuppression Treatment of Proliferative Lupus Nephritis: A Network Meta-analysis of Randomized Trials. – American Journal of Kidney Diseases (free)

 


Editorial: Cardiopulmonary Resuscitation after Hospital Admission with Covid-19 – The BMJ

“This pandemic has changed the risk-benefit balance for CPR: from “there is no harm in trying” to “there is little benefit to the patient, and potentially significant harm to staff.””

 


Richard Lehman’s covid-19 reviews, 6 April 2020 – The BMJ Opinion

In this weekly round-up, Richard Lehman looks at a personal selection of articles of relevance to clinicians dealing with covid-19.

 


NICE Publishes new COVID-19 Guidelines

6 Apr, 2020 | 01:57h | UTC

Alex Nowbar’s journal reviews, 3 April 2020 – The BMJ Opinion

Alex Nowbar reviews the latest research from the top medical journals.

 


Doctors Need Room to Make the Wrenching Decisions They Face – The New York Times

“New York is granting health care providers civil and criminal immunity during the coronavirus emergency. So should other states.”

 


How Hospitals Can Protect Frontline Healthcare Workers From COVID-19 – Medium

 

Related Commentary on Twitter

 


Efficacy of levetiracetam, fosphenytoin, and valproate for established status epilepticus by age group (ESETT): a double-blind, responsive-adaptive, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Source: Grupo UTIclínica – HCFMUSP

 

Related Commentary on Twitter

 


N95 Re-Use Instructions

30 Mar, 2020 | 02:06h | UTC

Primary care & Coronavirus (COVID 19): key guidance, information and support – Medium

Related: Coronavirus disease 2019 (covid-19): a guide for UK GPs – The BMJ AND Covid-19: a remote assessment in primary care – The BMJ

 

Related Commentary on Twitter

 


Prolonged presence of SARS-CoV-2 viral RNA in faecal samples – The Lancet Gastroenterology & Hepatology

“Very important article about viral shedding. Spoiler alert: quarantine may need to be much longer than 14 days. Virus is detectible in feces for up to 5 weeks. Caveat: virus not necessarily viable” (via @figgyjam see Tweet)

 


Postacute Care Preparedness for COVID-19: Thinking Ahead – JAMA

“Post-acute care preparedness for COVID19: we need to strengthen capacity in primary and community care to deal with those discharged from hospital.” (via @trishgreenhalgh see Tweet)

 


Practical Advice: PPE Pearls

26 Mar, 2020 | 01:49h | UTC

Review: Nonalcoholic Steatohepatitis

25 Mar, 2020 | 02:00h | UTC

N95 Re-Use Instructions:

Guidelines:

Stanford: N95 masks can be decontaminated without decreasing filtration efficiency using 70C heat for 30 min. Alcohol and bleach should not be used.” (via @CMichaelGibson see Tweet)

“…among patients with COVID-19 infection, clinicians are advised to only measure troponin if the diagnosis of acute MI is being considered on clinical grounds and an abnormal troponin should not be considered evidence for an acute MI without corroborating evidence.”

Podcasts:

Videos:

Practical Advice: PPE Pearls

COVID Ethics: Should clinicians see patients without appropriate PPE?

Reviews:

Selected Articles:

“Coronaviruses have not shown to cause a more severe disease in immunosuppressed patients. For this family of viruses the host innate immune response appears the main driver of lung tissue damage during infection.”

News & Perspectives:

COVID-19 Critical Care: This page will be updated as often as necessary and will be fixed in the right column on our homepage.

 


Guidelines:

Selected Articles:

“Very important article about viral shedding. Spoiler alert: quarantine may need to be much longer than 14 days. Virus is detectible in feces for up to 5 weeks. Caveat: virus not necessarily viable” (via @figgyjam see Tweet)

COVID-19 Gastroenterology: This page will be updated as often as necessary and will be fixed in the right column on our homepage.

 


COVID-19: Updates for Cardiologists

6 Apr, 2020 | 00:44h | UTC

Podcasts:

Guidelines:

“…among patients with COVID-19 infection, clinicians are advised to only measure troponin if the diagnosis of acute MI is being considered on clinical grounds and an abnormal troponin should not be considered evidence for an acute MI without corroborating evidence.”

Reviews:

Selected Articles:

COVID-19 Cardiology: This page will be updated as often as necessary and will be fixed in the right column on our homepage.

 


COVID-19: Updates in Bioethics

6 Apr, 2020 | 00:36h | UTC

Resource Centers:

Guidelines:

Videos:

Selected Articles:

News & Perspectives:

“New York is granting health care providers civil and criminal immunity during the coronavirus emergency. So should other states.”

COVID-19 Radiology: This page will be updated as often as necessary and will be fixed the right column in our homepage.

 


Infection Prevention and Control guidance for Long-Term Care Facilities in the context of COVID-19 – World Health Organization (PDF)

Related Study: COVID-19 in a Long-Term Care Facility — King County, Washington, February 27–March 9, 2020 – CDC Morbidity and Mortality Weekly Report (free)

“Introduction of COVID-19 into a long-term residential care facility in Washington resulted in cases among 81 residents, 34 staff members, and 14 visitors; 23 persons died” (from CDC)

 


Management of Kidney Stones in 2020

20 Mar, 2020 | 10:54h | UTC

FDA Approves Label Changes to SGLT2 Inhibitors Regarding Temporary Discontinuation of Medication Before Scheduled Surgery – U.S. Food & Drug Administration (free)

Commentary: FDA advises stopping SGLT2 inhibitor treatment prior to surgery – The Hospitalist (free)

“- Canagliflozin, dapagliflozin, and empagliflozin should each be discontinued at least three days before scheduled surgery.

Ertugliflozin should be discontinued at least four days before scheduled surgery.

– Blood glucose levels should be carefully monitored after discontinuation of the SGLT2 inhibitor and appropriately managed before surgery.”

 


Clinical Update: Tinnitus

17 Mar, 2020 | 08:38h | UTC

Clinical management of severe acute respiratory infection when novel coronavirus (nCoV) infection is suspected – World Health Organization (free PDF)

Related: Severe SARS-CoV-2 Infections: Practical Considerations and Management Strategy for Intensivists (free studies and reviews)

 

Related Commentary on Twitter

 


Mental Health and Psychosocial Considerations During COVID-19 Outbreak – World Health Organization (free PDF)

Related: The psychological impact of quarantine and how to reduce it: rapid review of the evidence – The Lancet (free) AND Behavioural scientists form new front in battle against coronavirus – The Guardian (free)

“Minimize watching, reading or listening to news that causes you to feel anxious or distressed; seek information only from trusted sources and mainly to take practical steps to prepare your plans and protect yourself and loved ones.”