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Infectious Diseases (all articles)

M-A | Efficacy and safety of treatments for different stages of syphilis.

18 Nov, 2022 | 13:20h | UTC

Efficacy and Safety of Treatments for Different Stages of Syphilis: a Systematic Review and Network Meta-Analysis of Randomized Controlled Trials and Observational Studies – Microbiology Spectrum

 

SR | Mosquito aquatic habitat modification and manipulation interventions to control malaria.

17 Nov, 2022 | 12:06h | UTC

Mosquito aquatic habitat modification and manipulation interventions to control malaria – Cochrane Library

 

M-A | A short course of antibiotics is noninferior to long-course therapy in children with nonsevere pneumonia.

16 Nov, 2022 | 13:43h | UTC

Short-Course vs Long-Course Antibiotic Therapy for Children With Nonsevere Community-Acquired Pneumonia: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)

Commentary: Review: Shorter antibiotic course sufficient for kids with pneumonia – CIDRAP

Related:

RCT | Among neonates with probable bacterial infection, switching from intravenous to oral antibiotics (amoxicillin–clavulanic acid) was noninferior to a full course of intravenous antibiotics and resulted in shorter hospitalization (median duration of 3.4 vs. 6.8 days).

RCT: In children with community-acquired pneumonia, outpatient antibiotic therapy for 5 days resulted in similar clinical response rates compared to a standard 10-day strategy.

ACP Guidance: Appropriate Use of Short-Course Antibiotics in Common Infections

RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia

RCT: Among children with community-acquired pneumonia discharged within 48 hours from the ED or hospital, lower-dose outpatient oral amoxicillin was noninferior to a higher dose, and a 3-day duration course was noninferior to 7 days.

Treatment of urinary tract infections in infants <2 Months: A Living Systematic Review – short and long duration of parenteral antibiotics were associated with a similar risk of UTI recurrence.

RCT: 7 days of antibiotic therapy as good as 14 days for afebrile men with urinary tract infection.

Randomized Trial: Seven vs. Fourteen Days of Antibiotic Therapy for Uncomplicated Gram-negative Bacteremia

Meta-Analysis: Efficacy of Short-Course Antibiotic Treatments for Community-Acquired Pneumonia

 

RCT | Evaluation of two short, standardized regimens for the treatment of rifampicin-resistant tuberculosis.

15 Nov, 2022 | 12:57h | UTC

Evaluation of two short standardised regimens for the treatment of rifampicin-resistant tuberculosis (STREAM stage 2): an open-label, multicentre, randomised, non-inferiority trial – The Lancet

Commentary: 

Shorter treatment effective for drug-resistant tuberculosis – University College London

Shorter Treatment Regimen for Drug-Resistant TB is More Effective – Health Policy Watch

 

RCT | Helicobacter pylori eradication may prevent peptic ulcer bleeding in older patients prescribed aspirin in primary care.

11 Nov, 2022 | 14:00h | UTC

Helicobacter pylori eradication for primary prevention of peptic ulcer bleeding in older patients prescribed aspirin in primary care (HEAT): a randomised, double-blind, placebo-controlled trial – The Lancet

News Release: Cutting the risk of stomach bleeding, occasionally caused by regular aspirin use – University of Nottingham

 

Commentary on Twitter

 

SR | Biomarkers as point‐of‐care tests to guide use of antibiotics in people with acute respiratory infections in primary care.

11 Nov, 2022 | 13:47h | UTC

Biomarkers as point‐of‐care tests to guide prescription of antibiotics in people with acute respiratory infections in primary care – Cochrane Library

 

RCT | No benefit from a model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients.

11 Nov, 2022 | 13:46h | UTC

Model-informed precision dosing of beta-lactam antibiotics and ciprofloxacin in critically ill patients: a multicentre randomised clinical trial – Intensive Care Medicine

 

Commentary on Twitter

 

Phase 2b RCT | Efficacy and safety of Bepirovirsen in chronic Hepatitis B infection.

11 Nov, 2022 | 13:44h | UTC

Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Editorial | The urgent need to recognize and properly address prenatal-onset group B Streptococcus disease.

10 Nov, 2022 | 13:59h | UTC

The urgent need to recognize and properly address prenatal-onset group B Streptococcus disease – International Journal of Infectious Diseases

 

RCT | Efficacy of 9 months of delamanid, linezolid, levofloxacin, and pyrazinamide for treatment of fluoroquinolone-sensitive MDR-TB.

9 Nov, 2022 | 12:11h | UTC

9 months of delamanid, linezolid, levofloxacin, and pyrazinamide versus conventional therapy for treatment of fluoroquinolone-sensitive multidrug-resistant tuberculosis (MDR-END): a multicentre, randomised, open-label phase 2/3 non-inferiority trial in South Korea – The Lancet (link to abstract – $ for full-text)

 

RCT | Moxidectin and albendazole vs. ivermectin and albendazole in adolescents infected with Trichuris trichiura.

9 Nov, 2022 | 12:10h | UTC

Efficacy and safety of moxidectin and albendazole compared with ivermectin and albendazole coadministration in adolescents infected with Trichuris trichiura in Tanzania: an open-label, non-inferiority, randomised, controlled, phase 2/3 trial – The Lancet Infectious Diseases

Invited Commentary: Alternative treatment strategies for trichuriasis – The Lancet Infectious Diseases

 

Guideline | Antibiotic prophylaxis for tube thoracostomy placement in trauma.

8 Nov, 2022 | 12:19h | UTC

Antibiotic prophylaxis for tube thoracostomy placement in trauma: a practice management guideline from the Eastern Association for the Surgery of Trauma

 

Guidelines for empirical antibacterial therapy of sepsis in adults.

7 Nov, 2022 | 12:40h | UTC

The 2021 Dutch Working Party on Antibiotic Policy (SWAB) guidelines for empirical antibacterial therapy of sepsis in adults – BMC Infectious Diseases

 

Review | Early appropriate diagnostics and treatment of MDR Gram-negative infections.

7 Nov, 2022 | 12:19h | UTC

Early appropriate diagnostics and treatment of MDR Gram-negative infections – JAC-Antimicrobial Resistance

Related:

The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic – European Respiratory Review

A position paper for the diagnosis and management of infections caused by multidrug-resistant bacteria: Endorsed by the Italian Society of Infection and Tropical Diseases (SIMIT), the Italian Society of Anti-Infective Therapy (SITA), the Italian Group for Antimicrobial Stewardship (GISA), the Italian Association of Clinical Microbiologists (AMCLI), and the Italian Society of Microbiology (SIM) – International Journal of Antimicrobial Agents

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0 – Infectious Diseases Society of America

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0 – Infectious Diseases Society of America

 

Commentary on Twitter

Under a https://creativecommons.org/licenses/by/4.0/ license

 

Review | The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections.

7 Nov, 2022 | 12:17h | UTC

The threat of multidrug-resistant/extensively drug-resistant Gram-negative respiratory infections: another pandemic – European Respiratory Review

Related:

Early appropriate diagnostics and treatment of MDR Gram-negative infections – JAC-Antimicrobial Resistance

A position paper for the diagnosis and management of infections caused by multidrug-resistant bacteria: Endorsed by the Italian Society of Infection and Tropical Diseases (SIMIT), the Italian Society of Anti-Infective Therapy (SITA), the Italian Group for Antimicrobial Stewardship (GISA), the Italian Association of Clinical Microbiologists (AMCLI), and the Italian Society of Microbiology (SIM) – International Journal of Antimicrobial Agents

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 2.0 – Infectious Diseases Society of America

IDSA Guidance on the Treatment of Antimicrobial-Resistant Gram-Negative Infections: Version 1.0 – Infectious Diseases Society of America

 

Review | How and when to manage respiratory infections out of hospital.

7 Nov, 2022 | 12:15h | UTC

How and when to manage respiratory infections out of hospital – European Respiratory Review

 

M-A | Prevalence, risk factors and treatments for post-COVID-19 breathlessness.

7 Nov, 2022 | 12:14h | UTC

Prevalence, risk factors and treatments for post-COVID-19 breathlessness: a systematic review and meta-analysis – European Respiratory Review

 

Review | Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD.

7 Nov, 2022 | 12:11h | UTC

Clinical significance of the neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in acute exacerbations of COPD: present and future – European Respiratory Review

 

Review | Non-Aspergillus mold lung infections.

7 Nov, 2022 | 11:51h | UTC

Non-Aspergillus mould lung infections – European Respiratory Review 

 

Review | Respiratory viruses: their importance and lessons learned from COVID-19.

7 Nov, 2022 | 11:54h | UTC

Respiratory viruses: their importance and lessons learned from COVID-19 – European Respiratory Review

 

A multinational Delphi consensus to end the COVID-19 public health threat.

4 Nov, 2022 | 14:01h | UTC

A multinational Delphi consensus to end the COVID-19 public health threat – Nature

 

Perspective | Monkeypox — A sobering sentinel for pandemic preparedness and sexual health system capacity.

4 Nov, 2022 | 13:53h | UTC

Monkeypox — A Sobering Sentinel for Pandemic Preparedness and Sexual Health System Capacity – New England Journal of Medicine

Related:

CDC study shows healthcare workers have a low risk of infection after exposure to patients with monkeypox.

Monkeypox – New England Journal of Medicine

Diagnosis and Management of Monkeypox: A Review for the Emergency Clinician – Annals of Emergency Medicine

Monkeypox: disease epidemiology, host immunity and clinical interventions.

Monkeypox: A clinical update for paediatricians – Journal of Pediatrics and Child Health

Cohort Study | Clinical presentation and virological assessment of confirmed human monkeypox virus cases in Spain.

CDC Report | Epidemiologic and clinical characteristics of Monkeypox cases in the US.

Update on the Monkeypox Outbreak – JAMA

Antivirals with Activity Against Monkeypox: A Clinically Oriented Review – Clinical Infectious Diseases

Clinical features and novel presentations of human monkeypox in a central London centre during the 2022 outbreak: descriptive case series – The BMJ

WHO Declares Global Public Health Emergency Over Monkeypox Virus Outbreak – Health Policy Watch

Monkeypox Virus Infection in Humans across 16 Countries — April–June 2022 – New England Journal of Medicine

Monkeypox: A Contemporary Review for Healthcare Professionals – Open Forum Infectious Diseases

 

Commentary on Twitter

 

Cohort Study | Covid-19 vaccine effectiveness among children and adolescents in Qatar.

4 Nov, 2022 | 13:51h | UTC

Covid-19 Vaccine Protection among Children and Adolescents in Qatar – New England Journal of Medicine

 

Commentary on Twitter

 

RCT | Clinical and cost-effectiveness of single stage compared vs. two-stage revision for hip prosthetic joint infection.

4 Nov, 2022 | 13:49h | UTC

Clinical and cost effectiveness of single stage compared with two stage revision for hip prosthetic joint infection (INFORM): pragmatic, parallel group, open label, randomised controlled trial – The BMJ

 

RCT | Oral antimicrobial prophylaxis reduced surgical site infection after elective colorectal surgery.

4 Nov, 2022 | 13:48h | UTC

Effect of oral antimicrobial prophylaxis on surgical site infection after elective colorectal surgery: multicentre, randomised, double blind, placebo controlled trial – The BMJ 

 

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