Infectious Diseases

Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study – The Lancet (free)

Commentaries: A global accounting of sepsis – The Lancet (free) AND Sepsis associated with 1 in 5 deaths globally, double previous estimate – Institute for Health Metrics and Evaluation (free)


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Urgent health challenges for the next decade – World Health Organization (free)

Commentary: ‘No shortcuts to a healthier world’: WHO chief sets out health priorities for the decade – UN News (free)


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You Are Unvaccinated and Got Sick. These Are Your Odds. – The New York Times (10 articles per month are free)

“Comparing the dangerous effects of three diseases with the minimal side effects of their corresponding vaccines.”


Adverse events in adults with latent tuberculosis infection receiving daily rifampicin or isoniazid: post-hoc safety analysis of two randomised controlled trials – The Lancet Infectious Diseases (free registration required)

Commentaries: What is the best regimen to treat latent tuberculosis infection? – The Lancet Infectious Diseases (free) AND Four Months of Rifampicin May Be Best Option for Latent TB – Medscape / Reuters (free registration required)


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Global burden of cancer attributable to infections in 2018: a worldwide incidence analysis – The Lancet Global Health (free)


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WHO World malaria report 2019

6 Dec, 2019 | 10:34h | UTC

World malaria report 2019 – World Health Organization (free PDF)

Summary: World malaria report 2019 – World Health Organization (free)

News Release: More pregnant women and children protected from malaria, but accelerated efforts and funding needed to reinvigorate global response, WHO report shows (free)


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The case for mandatory vaccination – Nature (free)

Related Opinion: Mandate Vaccination with Care (free commentaries)

“When immunization rates dip, legislation is often strengthened. But does the evidence stack up?”


Evaluating a digital sepsis alert in a London multisite hospital network: a natural experiment using electronic health record data – Journal of the American Medical Informatics Association (free)

Commentary: Digital monitoring system helps improve hospital care of sepsis patients – OnMedica (free) AND Sepsis digital alert ‘led to faster treatment with antibiotics’ – BBC (free)


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Why is the world losing the fight against history’s most lethal disease? – The Guardian (free)

Opinion piece by Dr. Tedros Adhanom Ghebreyesus, Director-General of the World Health Organization (WHO)


Randomized Trial of Perioperative Probiotics Among Patients Undergoing Major Abdominal Operation – Journal of the American College of Surgeons (link to abstract – $ for full-text)

Source: EvidenceAlerts

“A significantly higher readmission rate was observed among those exposed to probiotics. Additional studies remain warranted.”


Genomic and epidemiological evidence of bacterial transmission from probiotic capsule to blood in ICU patients – Nature Medicine (link to abstract – $ for full-text)

Related: Systematic Review: Harms Reporting in Trials with Probiotics (link to abstract and commentaries) AND The Problem With Probiotics – The New York Times (free)


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The second-hand effects of antibiotics: communicating the public health risks of drug resistance – JAC-Antimicrobial Resistance (free)


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Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010–15: a population-based, longitudinal study – The Lancet Infectious Diseases (free) (via @otavio_ranzani see Tweet)

Invited Commentary: Tuberculosis: an instrument of early mortality in life course (free)


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Sepsis hysteria: excess hype and unrealistic expectations – The Lancet (free)

Commentary: Sepsis myths create ‘unhealthy climate of fear’, say experts – The Guardian (free)

Source: Grupo UTIclínica – HCFMUSP


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Is Mycobacterium tuberculosis infection life long? – The BMJ (free)

Commentaries: Tuberculous infection is not life-long in most people – University of Pennsylvania School of Medicine (free) AND In the absence of a true test for latent TB we need shorter, safer preventive treatments – The BMJ Opinion (free)


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Podcast: Tuberculosis Updates

22 Oct, 2019 | 08:05h | UTC

WHO Global Tuberculosis Report 2019

18 Oct, 2019 | 08:29h | UTC

Complexity in Assessing the Benefit vs Risk of Vaccines: Experience With Rotavirus and Dengue Virus Vaccines – JAMA (free for a limited period)

“At what threshold does a large reduction in disease burden for society justify the small risk of an adverse reaction to an individual?”


Penicillin V four times daily for five days versus three times daily for 10 days in patients with pharyngotonsillitis caused by group A streptococci: randomised controlled, open label, non-inferiority study – The BMJ (free)


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The global burden of non-typhoidal salmonella invasive disease: a systematic analysis for the Global Burden of Disease Study 2017 – The Lancet Infectious Diseases (free)

Invited Commentary: Non-typhoidal salmonella: invasive, lethal, and on the loose (free)


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Multiple-dose versus single-dose ivermectin for Strongyloides stercoralis infection (Strong Treat 1 to 4): a multicentre, open-label, phase 3, randomised controlled superiority trial – The Lancet Infectious Diseases (link to abstract – $ for full-text)


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Oral Lefamulin vs Moxifloxacin for Early Clinical Response Among Adults With Community-Acquired Bacterial Pneumonia: The LEAP 2 Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Lefamulin—A New Antibiotic for Community-Acquired Pneumonia (free for a limited period)


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Immunogenicity, effectiveness, and safety of measles vaccination in infants younger than 9 months: a systematic review and meta-analysis – The Lancet Infectious Diseases (free)

Related Article: Effect of measles vaccination in infants younger than 9 months on the immune response to subsequent measles vaccine doses: a systematic review and meta-analysis – The Lancet Infectious Diseases (free)

Invited Commentary: Early vaccination: a provisional measure to prevent measles in infants (free)


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C-section babies are missing key microbes – Nature News (free)

Original Study: Stunted microbiota and opportunistic pathogen colonization in caesarean-section birth – Nature (link to abstract – $ for full-text)

Other Commentaries: Babies’ gut bacteria affected by delivery method, Baby Biome project shows – Wellcome Sanger Institute (free) AND Babies born by C-section have more potentially infectious bacteria in their guts – ScienceNews (free)

“UK study provides the best evidence yet that the way infants are born can alter their microbiomes — but the health effects are unclear.”


NICE Guideline: Tuberculosis

13 Sep, 2019 | 08:27h | UTC

What Is Known About Candida auris – JAMA (free for a limited period)

Related: Global Epidemiology of Emerging Candida Auris (reviews and commentaries on the subject)


Chlorhexidine bathing of the critically ill for the prevention of hospital‐acquired infection – Cochrane Library (free)

Summary: Bathing critically ill patients with chlorhexidine to prevent hospital-acquired infections – Cochrane Library (free)

“Due to the very low-certainty evidence available, it is not clear whether bathing with chlorhexidine reduces hospital-acquired infections, mortality, or length of stay in the ICU”