Infectious Diseases

Perspective: Why Are Mothers Still Passing Syphilis to Their Babies? – JAMA (free for a limited period)

Related: A Rising Threat to Pregnant Women: Syphilis – The New York Times (10 articles per month are free)


A practical guide for pharmacists to successfully implement penicillin allergy skin testing – American Journal of Health-System Pharmacy (free)

“Less than 10% of patients labeled as having a penicillin allergy are confirmed as present upon skin testing. This labeling results in use of alternative antibiotics and thus unwanted adverse consequences including potentiated antimicrobial resistance, increased costs, and worse clinical outcomes.”


2019 ACIP Adult Immunization Schedule

5 Feb, 2019 | 00:39h | UTC

International Consensus Guidelines for the Optimal Use of the Polymyxins – Pharmacotherapy (free)

Endorsed by the American College of Clinical Pharmacy (ACCP), European Society of Clinical Microbiology and Infectious Diseases (ESCMID), Infectious Diseases Society of America (IDSA), International Society for Anti‐infective Pharmacology (ISAP), Society of Critical Care Medicine (SCCM), and Society of Infectious Diseases Pharmacists (SIDP).


Oral versus Intravenous Antibiotics for Bone and Joint Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Related Trial: Partial Oral vs. Intravenous Antibiotic Treatment of Endocarditis (link to abstract and commentaries)

Commentary: Oral antibiotics may work for some ortho, heart infections – CIDRAP (free)


Related Commentary on Twitter

Ebola Has Gotten So Bad, It’s Normal

18 Jan, 2019 | 00:58h | UTC

Accelerating the elimination of viral hepatitis – Commissions from the Lancet journals (free articles – registration required)


Related Commentary on Twitter


Podcast: Herpes for Everyone

13 Jan, 2019 | 14:21h | UTC

Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST – Health Technology Assessment (free)


Related Commentary on Twitter


Review: Chikungunya Virus

3 Jan, 2019 | 11:17h | UTC

Clinical Practice Guidelines by the Infectious Diseases Society of America: 2018 Update on Diagnosis, Treatment, Chemoprophylaxis, and Institutional Outbreak Management of Seasonal Influenza – Clinical Infectious Diseases (free)

News Release: Flu is Serious for Pregnant Women and Others at High Risk: Testing and Treatment are Key, Say IDSA Guidelines (free)


Related Commentary on Twitter


WHO: Why the HIV Epidemic is Not Over

4 Dec, 2018 | 00:04h | UTC

Fluoroquinolones and the risk of aortopathy: A systematic review and meta-analysis – International Journal of Cardiology (free)

“…current fluoroquinolone use was significantly associated with increased risk of aortic aneurysm and dissection.”


The Global Burden of Tuberculosis Study

23 Nov, 2018 | 00:23h | UTC

WHO World Malaria Report 2018

20 Nov, 2018 | 15:46h | UTC

Review: Hepatic Echinococcosis

20 Nov, 2018 | 15:11h | UTC

Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS – New England Journal of Medicine (free)

“Prednisone treatment during the first 4 weeks after the initiation of ART for HIV infection resulted in a lower incidence of tuberculosis-associated immune reconstitution inflammatory syndrome than placebo, without evidence of an increased risk of severe infections or cancers.”


Review: Neuroinfections Caused by Fungi

16 Nov, 2018 | 02:51h | UTC

Diagnostic value of symptoms and signs for identifying urinary tract infection in older adult outpatients: Systematic review and meta-analysis – The Journal of Infection (free)

“A number of symptoms and signs typically associated with UTI, such as nocturia, urgency and abnormal vital signs, were of limited use in older adult outpatients.”


Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

Summary: Preventative antibiotic therapy for people with COPD – Cochrane Library (free)

“Use of continuous and intermittent prophylactic antibiotics results in a clinically significant benefit in reducing exacerbations in COPD patients.”


Efficacy, effectiveness, and safety of herpes zoster vaccines in adults aged 50 and older: systematic review and network meta-analysis – The BMJ (free)

“Using the adjuvant recombinant subunit vaccine might prevent more cases of herpes zoster than using the live attenuated vaccine, but the adjuvant recombinant subunit vaccine also carries a greater risk of adverse events at injection sites.”


Decontamination Strategies and Bloodstream Infections With Antibiotic-Resistant Microorganisms in Ventilated Patients: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Decontamination of Oral or Digestive Tract for Patients in the Intensive Care Unit (free for a limited period)

“Among patients receiving mechanical ventilation in ICUs with moderate to high ABX resistance prevalence, use of chlorhexidine mouthwash, selective oropharyngeal decontamination, or selective digestive tract decontamination was not associated with reductions in ICU-acquired bloodstream infections caused by MDRGNB vs standard care” (via @JAMA_current see Tweet with visual abstract)


Podcast: HIV Care for the Internist

26 Oct, 2018 | 01:48h | UTC

Antibiotics May Soon Become Useless. Now What? – WIRED (a few articles per month are free)


Review: A New Vaccine for Shingles

12 Oct, 2018 | 01:44h | UTC

Shingrix: A New Vaccine for Shingles – Therapeutics Initiative (free)

“Need to vaccinate 31 people to prevent one instance of HZ; Need to vaccinate 358 people to prevent one instance on post herpetic neuralgia” (via @amtejani)


The Case For Expensive Antibiotics – WIRED (a few articles per month are free) (via @CarlosdelRio7)