Hematology

Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant – JAMA Internal Medicine (free for a limited period)

Commentary: Study Sheds Light on Stopping and Resuming DOACs in Afib Patients Undergoing Surgery – NEJM Journal Watch (free)

“The DOAC regimens were omitted for 1 day before a low–bleeding-risk procedure and 2 days before a high–bleeding-risk procedure. The DOAC regimens were resumed 1 day after a low–bleeding-risk procedure and 2 to 3 days after a high–bleeding-risk procedure.”

 

Related Commentary on Twitter

 


Clinical Guide and Update on Porphyrias

26 Jul, 2019 | 01:11h | UTC

Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis – The BMJ (free)

Commentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)

“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”

 

Related Commentary on Twitter

 


The Promise and Price of Cellular Therapies – The New Yorker (a few articles per month are free)

“New “living drugs”—made from a patient’s own cells—can cure once incurable cancers. But can we afford them?”

 


NCCN Guideline: Acute Myeloid Leukemia

2 Jul, 2019 | 01:16h | UTC

Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis – Blood Advances (free)

Our findings indicate that patients on VKA therapy who have an INR between 4.5 and 10.0 without bleeding are not likely to benefit from vitamin K administration in addition to temporary VKA cessation.”

 


NCCN Guideline: Systemic Mastocytosis

9 Jan, 2019 | 08:48h | UTC

Transfusion of red blood cells stored for shorter versus longer duration for all conditions – Cochrane Library (free)

Summary: Transfusion of red blood cells stored for a shorter duration versus red blood cells stored for a longer duration for all conditions – Cochrane Library (free)

 

 


Review: Cancer-Associated Thrombosis

5 Nov, 2018 | 11:51h | UTC

NICE Guideline: Multiple Myeloma

2 Nov, 2018 | 02:33h | UTC

Intravenous Iron in Patients Undergoing Maintenance Hemodialysis – New England Journal of Medicine (free)

“Proactive administration of high-dose iv iron did not adversely affect mortality or CV events, but enabled reduced erythropoiesis-stimulating agent dosing and transfusion rates.” (via @NatRevNeph see Tweet)

 


Review: Cancer-Associated Thrombosis

16 Oct, 2018 | 21:45h | UTC

Review: Rare Thrombophilic Conditions

16 Oct, 2018 | 21:34h | UTC

Guideline: Immune Thrombocytopenia

27 Sep, 2018 | 22:25h | UTC

Guideline: Hodgkin Lymphoma in Adults

2 Sep, 2018 | 02:03h | UTC

Six-Month Outcomes after Restrictive or Liberal Transfusion for Cardiac Surgery – New England Journal of Medicine (free for a limited period)

“In moderate-to-high-risk patients undergoing cardiac surgery, six-month outcomes show that a restrictive red-cell transfusion strategy is noninferior to a liberal strategy” (via @NEJM see Tweet with Visual Abstract)

 


Guideline: Pediatric CAR T-Cell Therapy

16 Aug, 2018 | 23:16h | UTC

ESMO Guideline: Hodgkin lymphoma

1 Jun, 2018 | 03:12h | UTC

Global Burden of Multiple Myeloma: A Systematic Analysis for the Global Burden of Disease Study 2016 – JAMA Oncology (free)

“Global incident cases of multiple myeloma more than doubled from 1990-2016 w/incident cases increasing by 126%. The largest increase was in middle-SDI countries, particularly E. Asia with a 262% increase in incidence cases”. (via @IHME_UW see Tweet)

 


Review: Chronic Lymphocytic Leukemia

9 May, 2018 | 16:15h | UTC

Antifibrinolytics for heavy menstrual bleeding – Cochrane Library (link to abstract and summary)

“Antifibrinolytics appear effective tor treating for heavy menstrual bleeding, without substantially increasing the rate of adverse events” (via @CochraneLibrary see Tweet)

 


Guideline: Iron Deficient Anemia

12 Apr, 2018 | 02:14h | UTC

Clinical Practice Guideline: Iron Deficient Anemia – Toward Optimized Practice (TOP) (free PDF)

See also: Summary (free PDF)

Related: see all TOP Clinical Practice Guidelines, a practical resource for Family Physicians at the point of care.

 


NCCN Guideline: Hodgkin Lymphoma

16 Mar, 2018 | 01:35h | UTC

NCCN Guideline: T-Cell Lymphomas

8 Mar, 2018 | 20:30h | UTC