Gynecology & Obstetrics

Three versus five days of pivmecillinam for community-acquired uncomplicated lower urinary tract infection: A randomised, double-blind, placebo-controlled superiority trial – EClinicalMedicine (free)

 

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Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial – The Lancet (free)

Commentary: Oral regimen management of acute hypertension in pregnancy – The Lancet (free)

 

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Association of Early Interventions With Birth Outcomes and Child Linear Growth in Low-Income and Middle-Income Countries: Bayesian Network Meta-analyses of Randomized Clinical Trials – JAMA Network Open (free)

 

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The impact of occupational shift work and working hours during pregnancy on health outcomes: a systematic review and meta-analysis – American Journal of Obstetrics & Gynecology (link to abstract – for full-text)

Commentary: Night shifts, long hours linked to miscarriages and preterm births – Reuters (free)

 

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International consensus statement on the use of uterotonic agents during caesarean section – Anaesthesia (free)

 

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State of The Art Review: Pre-eclampsia: pathophysiology and clinical implications – The BMJ (free for a limited period)

 


Delayed childhood neurodevelopment and neurosensory alterations in the second year of life in a prospective cohort of ZIKV-exposed children – Nature Medicine (link to abstract – $ for full-text)

News Release: A third of children up to age 3 exposed to Zika in-utero have neurological problems – UCLA (free) AND Maternal Zika infection tied to poor development in 32% of tots – CIDRAP (free)

 

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MRI versus mammography for breast cancer screening in women with familial risk (FaMRIsc): a multicentre, randomised, controlled trial – The Lancet Oncology (link to abstract – $ for full-text)

Commentary: MRI Breast Screening Better for Women With Familial Cancer Risk – MedPage Today (free registration required)

 

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Population-level impact and herd effects following the introduction of human papillomavirus vaccination programmes: updated systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)

Commentaries: Vaccination programs substantially reduce HPV infections and precancerous cervical lesions – Laval University (free) AND Hopes raised of cervical cancer eradication – BBC (free) AND Study shows major real-world impact of cervical cancer vaccines – Reuters (free)

 

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ESMO Guideline: Early Breast Cancer

24 Jun, 2019 | 01:49h | UTC

Surgical interventions for women with stress urinary incontinence: systematic review and network meta-analysis of randomised controlled trials – The BMJ (free)

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Review: Menopausal Hormone Therapy

31 May, 2019 | 06:30h | UTC

Menopausal Hormone Therapy – JAMA (free for a limited period)

Podcast: Menopausal Hormone Therapy (free audio)

 


Prophylactic antibiotics in the prevention of infection after operative vaginal delivery (ANODE): a multicentre randomised controlled trial – The Lancet (free)

Invited Commentary: Antibiotics for operative vaginal delivery: practice-changing data – The Lancet (free)

 

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Estimated Quality of Life and Economic Outcomes Associated With 12 Cervical Cancer Screening Strategies: A Cost-effectiveness Analysis – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Screening Options for Preventing Cervical Cancer (free for a limited period)

Author Interview: Estimated Quality of Life and Economic Outcomes Associated With Cervical Cancer Screening (free audio)

“Cytologic testing every 3 years and low-cost high-risk human papillomavirus testing every 5 years both may be considered reasonable cervical cancer screening options.”

 

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Association between Apgar scores of 7 to 9 and neonatal mortality and morbidity: population based cohort study of term infants in Sweden – The BMJ (free)

Commentaries: The Apgar score and association with neonatal mortality and morbidity – The BMJ Opinion (free) AND Lower ‘normal’ Apgar scores linked to poorer outcomes – OnMedica (free)

 

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Association of Gestational Weight Gain With Adverse Maternal and Infant Outcomes – JAMA (free for a limited period)

Editorial: Prepregnancy Body Mass Index, Weight Gain During Pregnancy, and Health Outcomes (free for a limited period)

“Optimal gestational weight gain ranges were 14.0 kg to less than 16.0 kg for women categorized as underweight; 10.0 kg to less than 18.0 kg for normal weight; 2.0 kg to less than 16.0 kg for overweight; 2.0 kg to less than 6.0 kg for obesity grade 1; weight loss or gain of 0 kg to less than 4.0 kg for obesity grade 2; and weight gain of 0 kg to less than 6.0 kg for obesity grade 3.”

 


Risk‐reducing medications for primary breast cancer: a network meta‐analysis – Cochrane Library (free)

Summary: Medicines to prevent breast cancer in women at above-average risk of developing breast cancer – Cochrane Library (free)

 

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Effects of repeat prenatal corticosteroids given to women at risk of preterm birth: An individual participant data meta-analysis – PLOS Medicine (free)

Source: EvidenceAlerts

“Our findings suggest that to provide clinical benefit with the least effect on growth, the number of repeat treatment courses should be limited to a maximum of three and the total dose to between 24 mg and 48 mg.”

 


Treatment of Nonmetastatic Breast Cancer – JAMA (free for a limited period)

A short review on the subject.

 


NICE Guideline: Cesarean section

12 Apr, 2019 | 01:43h | UTC

The clinical role of LASER for vulvar and vaginal treatments in gynecology and female urology: An ICS/ISSVD best practice consensus document – Neurourology and Urodinamics (free)

“At this point, LASER is not recommended for routine treatment of the aforementioned conditions unless part of well‐designed clinical trials”

 


Perspective: Mesh Implants for Women: Scandal or Standard of Care? – JAMA (free for a limited period)

 

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Mode of delivery and preterm birth in subsequent births: A systematic review and meta-analysis – PLOS One (free)

“A previous cesarean section could increase the risk of preterm birth in subsequent pregnancies”

 


A Randomized Trial of Prophylactic Antibiotics for Miscarriage Surgery – New England Journal of Medicine (free for a limited period)

Video Summary: Prophylactic Antibiotics before Miscarriage Surgery (free)

Commentaries: Research shines light on preventing infection after miscarriage – University of Birmingham (free) AND Antibiotics before miscarriage surgery not tied to fewer infections – CIDRAP (free)

 

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Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: nationwide case-control study – The BMJ (free)

Editorial: Menopausal hormone therapy and cognition (free)

Commentaries: Systemic Hormone Therapy Tied to Small Increase in Alzheimer’s Risk – NEJM Journal Watch (free) AND ‘Small’ increase in risk of Alzheimer’s disease with HRT use, study suggests – NHS Choices (free)

“The findings of this case-control study, with the modest effect sizes and substantial potential for bias, will not change how I counsel patients regarding benefits and risks of HT.” (from Journal Watch)

“Evidence is reassuring for women needing a few years’ treatment for menopausal symptoms” (from Editorial)

 


NCCN Guidelines Insights: Breast Cancer

27 Feb, 2019 | 12:41h | UTC

Management of Cardiovascular Disease in Women With Breast Cancer – Circulation (free)

Related: AHA Scientific Statement on Cardio-Oncology (several guidelines on the subject)

 

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A Review of the Role of Breast Arterial Calcification for Cardiovascular Risk Stratification in Women – Circulation (free)

Commentary: Breast Calcifications May Hold Important Clues for CV Risk Stratification – TCTMD (free)

 

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Perspective: Why Are Mothers Still Passing Syphilis to Their Babies? – JAMA (free for a limited period)

Related: A Rising Threat to Pregnant Women: Syphilis – The New York Times (10 articles per month are free)

 


Primary cervical screening with high risk human papillomavirus testing: observational study – The BMJ (free)

Commentaries: HPV cervical screening test switch ‘effective’, says pilot study – Cancer Research UK (free) AND Cervical screening intervals could be safely extended to at least five years – Pulse (free)

Related: USPSTF Statement: Screening for Cervical Cancer (free guidance and commentaries) AND Study: Little Benefit in Screening Women Aged 55 with a Negative HPV DNA test (link to abstract and commentaries) AND Randomized Trial: Cervical Cancer Screening with Cervical HPV Testing vs Cytology Testing (link to abstract and commentaries)

“The lower incidence of cervical intraepithelial neoplasia grade 3 or worse and cervical cancer at present screening intervals would strongly support the safety of extending the intervals to at least five years without increasing the risk of potentially life-threatening disease.”