Geriatrics
ASCO Guideline | Practical assessment and management of vulnerabilities in older patients receiving systemic cancer therapy
19 Jul, 2023 | 14:31h | UTC
RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns
18 Jul, 2023 | 13:51h | UTCDonanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial – JAMA (free for a limited period)
Editorials:
Donanemab for Alzheimer Disease—Who Benefits and Who Is Harmed? – JAMA (free for a limited period)
Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease – JAMA (free for a limited period)
Ushering in a New Era of Alzheimer Disease Therapy – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: Expert reaction to results from Eli Lilly on its anti-amyloid drug donanemab – Science Media Centre
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
RCT | Prostatic artery embolization improves symptoms more than combined medical therapy in BPH patients
18 Jul, 2023 | 13:34h | UTC
Guideline | Diagnosis and treatment of fragility fractures of the pelvis
14 Jul, 2023 | 12:39h | UTC
Practice Guidance | Six steps to better care for older people in acute hospitals
12 Jul, 2023 | 14:00h | UTCSix steps to better care for older people in acute hospitals – British Geriatrics Society
News Release: New guidance outlines ‘Six steps to better care for older people in hospital’ – British Geriatrics Society
Cohort Study | Long-term use of menopausal hormone therapy linked to heightened dementia risk
11 Jul, 2023 | 14:04h | UTCMenopausal hormone therapy and dementia: nationwide, nested case-control study – The BMJ
Editorial: Menopausal hormone therapy and dementia – The BMJ
News Release: Menopausal hormone therapy linked to increased rate of dementia – BMJ Newsroom
Commentaries: Expert reaction to observational study on HRT and dementia – Science Media Centre
Review | Evaluation of acute adult disorders of consciousness for the general intensivist
10 Jul, 2023 | 13:37h | UTCState-of-the-Art Evaluation of Acute Adult Disorders of Consciousness for the General Intensivist – Critical Care Medicine (free for a limited period)
Podcast | Untangling catheter associated UTIs
10 Jul, 2023 | 13:21h | UTC#402 Don’t Get Caught with a CAUTI – The Curbsiders
Consensus Paper | Subcutaneous infusions of hydration and medication in adults
7 Jul, 2023 | 16:27h | UTC
M-A | Interventions using wearable activity trackers to improve patient physical activity in adults who are hospitalized
30 Jun, 2023 | 14:46h | UTCAuthor Interview: Wearable Activity Trackers to Improve Physical Activity and Outcomes – JAMA
News Release: Wearable activity trackers accelerate hospital patient recovery – University of South Australia
Development and validation of an international preoperative risk assessment model for postoperative delirium
30 Jun, 2023 | 14:43h | UTC
RCT | Noninferior results with quick resumption of activity after pelvic organ prolapse surgery
30 Jun, 2023 | 14:38h | UTCStandard Restrictions vs Expedited Activity After Pelvic Organ Prolapse Surgery: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)
See also: Visual Abstract
Commentary: No Need to Avoid Exercise After Prolapse Surgery, Study Finds – HealthDay
Post hoc analysis | Low-dose aspirin linked to increased risk of anemia in older adults
29 Jun, 2023 | 14:06h | UTCSummary: In a post hoc analysis of the ASPREE randomized controlled trial, the impact of daily low-dose aspirin on anemia, hemoglobin, and serum ferritin concentrations in elderly individuals was investigated. The study included 19,114 community-dwelling individuals aged 70 years and older (or ≥65 years for Black and Hispanic individuals) from Australia and the United States.
Findings reveal an increased incidence of anemia in the aspirin group compared to the placebo group (51.2 events versus 42.9 events per 1000 person-years, respectively). This correlates to a 20% increase in risk (hazard ratio, 1.20 [95% CI, 1.12 to 1.29]). Hemoglobin concentrations displayed a more pronounced decline in the aspirin group by 0.6 g/L per 5 years. Additionally, among participants with ferritin measures, the aspirin group exhibited a greater prevalence of ferritin levels less than 45 µg/L at year 3 and overall decline in ferritin by 11.5%. The study found similar results even in the absence of major bleeding.
This research underscores the risk of anemia and decline in ferritin in otherwise healthy older adults taking low-dose aspirin, highlighting the need for periodic monitoring of hemoglobin levels. However, the study lacked data on the causes of anemia, indicating the need for further research.
Article: Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly: A Secondary Analysis of the Aspirin in Reducing Events in the Elderly Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
News Release: Low-dose aspirin may increase anaemia risk in healthy older adults: study – Monash University
Commentaries:
Aspirin Use Ups Risk of Anemia in Elderly Patients: ASPREE – TCTMD
Low-dose aspirin associated with 20% increase in risk of anemia among older adults – ACP Internist
Original Study: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly – New England Journal of Medicine
Consensus Paper | Care for older forensic mental health patients
29 Jun, 2023 | 13:54h | UTCCare for older forensic mental health patients: A consensus guidance document – European Psychiatry
Position Paper | Assessing and managing frailty in emergency laparotomy
27 Jun, 2023 | 13:45h | UTC
Choosing Wisely | Recommendations for advance care planning
22 Jun, 2023 | 15:18h | UTCSee complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
Scientific Statement | Hormones and aging
20 Jun, 2023 | 12:45h | UTCNews Release: Endocrine Society Scientific Statement distinguishes normal aging from endocrine disease – Endocrine Society
RCT | Testosterone replacement does not appear to increase cardiovascular events in hypogonadal men at high risk
19 Jun, 2023 | 14:13h | UTCCardiovascular Safety of Testosterone-Replacement Therapy – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Presented today at #ENDO2023: In the TRAVERSE study, a randomized trial involving men with hypogonadism and preexisting or a risk of cardiovascular disease, testosterone therapy was noninferior to placebo with respect to major adverse cardiac events. https://t.co/V3FTTsOLd1
— NEJM (@NEJM) June 16, 2023
M-A | Increased risk of cognitive toxic effects and fatigue in prostate cancer treatment with second-generation antiandrogens
16 Jun, 2023 | 14:00h | UTCAssociation of Second-generation Antiandrogens With Cognitive and Functional Toxic Effects in Randomized Clinical Trials: A Systematic Review and Meta-analysis – JAMA Oncology (link to abstract – $ for full-text)
ATS Report | Rehabilitation for people with respiratory disease and frailty
16 Jun, 2023 | 13:51h | UTC
Cluster RCT | Effects of implementation of a supervised walking program in veterans affairs hospitals
14 Jun, 2023 | 14:17h | UTCEffects of Implementation of a Supervised Walking Program in Veterans Affairs Hospitals: A Stepped-Wedge, Cluster Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Supervised Walking Program Benefits Veterans Admitted to Hospital – Physician’s Weekly
Commentary on Twitter
A supervised #WalkingProgram known as #STRIDE reduced skilled nursing facility admissions among older adults. https://t.co/nvkzcx5eVE pic.twitter.com/UJnJMtaxXG
— Annals of Int Med (@AnnalsofIM) June 8, 2023
M-A | Oseltamivir fails to lower hospitalization risk in adult and adolescent influenza patients
13 Jun, 2023 | 14:12h | UTC
Commentary on Twitter
In this systematic review and meta-analysis of 15 RCTs, oseltamivir was not associated with reduced risk of first hospitalization compared with placebo or standard of care among influenza-infected adult and adolescent outpatients. https://t.co/UEqsbA2JQZ
— JAMA Internal Medicine (@JAMAInternalMed) June 12, 2023
Review | Post-intensive care syndrome
13 Jun, 2023 | 13:44h | UTCPost-intensive care syndrome (PICS): recent updates – Journal of Intensive Care
Pre-clinical Study | Taurine deficiency and aging, a correlation found in mice, monkeys, and worms
12 Jun, 2023 | 13:53h | UTCTaurine deficiency as a driver of aging – Science
Invited Commentary: Taurine linked with healthy aging – Science
News Release: Taurine May Be a Key to Longer and Healthier Life – Columbia University
Commentary on Twitter
Taurine deficiency may be a driver for aging, finds a new Science study in several animal models. The results warrant clinical trials to examine taurine’s effect on healthy lifespan in humans.
?: https://t.co/iJfI4rne7o#SciencePerspective: https://t.co/EdOKecgoqF pic.twitter.com/dekChiKRN3
— Science Magazine (@ScienceMagazine) June 8, 2023
SR | Effectiveness of anticholinergic drugs for treating people with overactive bladder syndrome
12 Jun, 2023 | 13:41h | UTC