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Genetics

FDA News Release: FDA approval brings first gene therapy to the United States (free)

Commentaries: A $475,000 cancer drug: Wall Street sees ‘bargain’; patients see ‘completely broken’ system – HealthNewsReview (free) FDA Approves First CAR-T Cell Therapy for Pediatric Acute Lymphoblastic Leukemia – National Institutes of Health (free) AND FDA Approves First Gene-Altering Leukemia Treatment, Costing $475.000 – New York Times (10 articles per month are free) AND The FDA Approves a Landmark Cancer Drug – The Atlantic (free)

“…is a cancer therapy that represents several things at once: a game-changing way to treat cancer through genetic engineering, a novel paradigm for the biotech business, and the latest turn in the debate over just how astronomically expensive a life-saving therapy can be”. (from The Atlantic)

 


Commit to talks on patient data and public health – Nature News (free)

“unlike gene-edited infants, which are still years away, genomic medicine is with us now” (RT @NatureNews see Tweet)

 


Genetic testing threatens the insurance industry – The Economist (a few articles per month are free)

“Insurers worry about adverse selection; the insured worry about discrimination”

 


‘We are all mutants now’: the trouble with genetic testing – The Guardian (free) (RT @EricTopol see Tweet)

Related: The uncertain future of genetic testing – Mosaic (free)

“With so many unknowns in our DNA, using genetics in medical testing doesn’t always bring the answers – sometimes it brings only doubt”.

 


The Uncertain Future of Genetic Testing – The Atlantic (free)

“Bringing genetics into medicine leads to more accuracy, better diagnosis, and personalized treatment—but for some, gene testing has only resulted in unanswered questions”.

 


Immunology, one cell at a time – Nature News (free)

“Analysing the DNA, RNA and protein of single cells is transforming our understanding of the immune system, say Amir Giladi and Ido Amit”.

 


Single-cell sequencing made simple – Nature News (free)

“Data from thousands of single cells can be tricky to analyse, but software advances are making it easier”.

 


The Brave New World of Gene Editing – The New York Review of Books (free)

“In reviewing 3 recent books, @matthewcobb provides exceptional genomics perspective, especially on #CRISPR

 


New Natural Selection: How Scientists are Altering DNA to Genetically Engineer New Forms of Life – Newsweek (Free)

“What happens when you can write and edit genomes? Life 2.0? (RT @EricTopol see Tweet)

 


Precision Medicine: the Promise vs. the Reality – Michigan University Health Lab (free) (RT @pash22 see Tweet)

“Scientists find great potential in using genetic sequencing to help direct targeted cancer therapy, but practicing oncologists see some important limitations”.

 


New concerns raised over value of genome-wide disease studies – Nature News (free)

“Large analyses dredge up ‘peripheral’ genetic associations that offer little biological insight, researchers say”.

 


Insurers Battle Families Over Costly Drug for Fatal Disease – The New York Times (10 articles per month are free)

“A new drug can cost over a million dollars, even though it’s unclear if it works. Now, insurers are refusing to pay” (RT @NYTHealth see Tweet)

 


Viewpoint: No Shortcuts on the Long Road to Evidence-Based Genomic Medicine – JAMA (free)

“The need for evidence in genomic medicine is more important than ever” (RT @JAMA_current see Tweet)

 


Medical News & Perspectives: The Paternal Epigenome Makes Its Mark – JAMA (free)

Related: Influence of paternal preconception exposures on their offspring: through epigenetics to phenotype – American Journal of Stem Cells (free)

“Epigenetic changes may be the underlying mechanism by which paternal factors such as age, diet, weight, stress, and alcohol consumption contribute to a range of health outcomes in offspring including birth defects, behavioral problems, developmental disorders, obesity, diabetes, cardiovascular disease, and cancer”.

 


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