General Interest
RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns
18 Jul, 2023 | 13:51h | UTCDonanemab in Early Symptomatic Alzheimer Disease: The TRAILBLAZER-ALZ 2 Randomized Clinical Trial – JAMA (free for a limited period)
Editorials:
Donanemab for Alzheimer Disease—Who Benefits and Who Is Harmed? – JAMA (free for a limited period)
Amyloid-Targeting Monoclonal Antibodies for Alzheimer Disease – JAMA (free for a limited period)
Ushering in a New Era of Alzheimer Disease Therapy – JAMA (free for a limited period)
See also: Visual Abstract
Commentary: Expert reaction to results from Eli Lilly on its anti-amyloid drug donanemab – Science Media Centre
Related: RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns.
Health advisory on social media use in adolescence
11 Jul, 2023 | 14:03h | UTCHealth advisory on social media use in adolescence – American Psychological Association
News Release: APA panel issues recommendations for adolescent social media use – American Psychological Association
Cohort Study | Fewer than half of new drugs add substantial therapeutic value over existing treatments
11 Jul, 2023 | 14:01h | UTCNews Release: Fewer than half of new drugs add substantial therapeutic value over existing treatments – BMJ Newsroom
Editorial: Patients need better treatments, not just more of the same – The BMJ
Cohort Study | A diet high in fruits, vegetables, nuts, legumes, fish, and dairy linked with decreased mortality and CVD globally
10 Jul, 2023 | 13:39h | UTCDiet, cardiovascular disease, and mortality in 80 countries – European Heart Journal
News Release: Global diet study challenges advice to limit high-fat dairy foods – European Society of Cardiology
Commentary on Twitter
Fruits, vegetables, nuts, legumes, fish and dairy: the secret to a lower risk of cardiovascular risk and mortality! Read the Prospective Urban Rural Epidemiology study on #EHJ!#diet #cardiovascular #risk #cardiotwitter #EHJ @ESC_Journals @escardio https://t.co/uzDYdhf6DI pic.twitter.com/54ZN3pa6cN
— EHJ Editor-in-Chief (@ehj_ed) July 9, 2023
Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050
26 Jun, 2023 | 01:00h | UTCSummary: This systematic review analyzed the global burden of diabetes, including trends, projections, and attributions to risk factors. It considered data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD), covering 204 countries and territories.
In 2021, an estimated 529 million people worldwide were living with diabetes. Regionally, the highest rates were observed in North Africa, the Middle East, and Oceania. Type 2 diabetes accounted for 96% of diabetes cases and 95.4% of diabetes DALYs (disability-adjusted life-years). More than half of global type 2 diabetes DALYs were attributable to high body mass index (BMI).
Predictions suggest that more than 1.31 billion people will have diabetes by 2050, with high prevalence rates in North Africa, the Middle East, and Latin America. The study notes the ongoing challenge of preventing and controlling type 2 diabetes, largely driven by increasing obesity. An understanding of disparities in risk profiles and disease burdens can inform strategies to control diabetes risk factors.
Editorial: Diabetes: a defining disease of the 21st century – The Lancet
News Release: Global diabetes cases to soar from 529 million to 1.3 billion by 2050 – Institute for Health Metrics and Evaluation
Commentary on Twitter (thread – click for more)
Today: More than 529 million people across the globe have diabetes
In the next 30 years: 1.3 billion people are projected to have diabetes
https://t.co/gh2O0K7RY0— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) June 22, 2023
Editorial | How to become a good surgeon
22 Jun, 2023 | 15:12h | UTCHow to become a good surgeon – Advances in Ophthalmology Practice and Research
Perspective | Benefits and pitfalls of social media in cardiology
16 Jun, 2023 | 14:13h | UTC
Commentary on Twitter
Medical #education has entered the #DigitalTransformation era ?
What is the role of #SoMe and multimedia platforms in #cardiology❓
Here is our view from the @JACCJournals #JACCCaseReports #SoMe Editors ❤️#CardioTwitter #MedEd #CardioEd
➡️Link to full paper below? pic.twitter.com/0W77HzoJ6Q
— Alessandro Beneduce (@ABeneduceMD) June 9, 2023
RCT | Cannabis-based medicines show no significant relief for moderate-to-severe cancer pain
15 Jun, 2023 | 15:10h | UTCCannabis‐based medicines and medical cannabis for adults with cancer pain – Cochrane Library
Summary: Cannabis-based medicines for cancer pain – Cochrane Library
Perspective | Inside the nascent industry of AI-designed drugs
14 Jun, 2023 | 14:50h | UTCInside the nascent industry of AI-designed drugs – Nature (if the link is paywalled, try this one)
Opinion | Threats by artificial intelligence to human health and human existence
14 Jun, 2023 | 14:47h | UTCThreats by artificial intelligence to human health and human existence – BMJ Global Health
News Release: Doctors and public health experts join calls for halt to AI R&D until it’s regulated – BMJ Newsroom
Pre-clinical Study | Taurine deficiency and aging, a correlation found in mice, monkeys, and worms
12 Jun, 2023 | 13:53h | UTCTaurine deficiency as a driver of aging – Science
Invited Commentary: Taurine linked with healthy aging – Science
News Release: Taurine May Be a Key to Longer and Healthier Life – Columbia University
Commentary on Twitter
Taurine deficiency may be a driver for aging, finds a new Science study in several animal models. The results warrant clinical trials to examine taurine’s effect on healthy lifespan in humans.
?: https://t.co/iJfI4rne7o#SciencePerspective: https://t.co/EdOKecgoqF pic.twitter.com/dekChiKRN3
— Science Magazine (@ScienceMagazine) June 8, 2023
SR | Limited evidence for vitamin and mineral supplements in delaying dementia in people with mild cognitive impairment
7 Jun, 2023 | 14:09h | UTC
Commentary on Twitter
? How does vitamin and mineral supplementation affect #cognitivefunction and progression to #dementia in people with mild cognitive impairment (MCI)?
Get the current evidence picture in this #systematicreview on @CochraneLibrary: https://t.co/YUsbjELIZq@NIH_ODS #NSHFD pic.twitter.com/hRl27Tm7op— Cochrane CAM (@CochraneCAM) May 31, 2023
Review | How to understand the 95% confidence interval around the relative risk, odds ratio, and hazard ratio
6 Jun, 2023 | 14:37h | UTC
Perspective | How to use social media for scientific advocacy and personal branding
2 Jun, 2023 | 12:22h | UTCHow to use social media for scientific advocacy and personal branding – UEG Journal
SR | Individual‐level interventions for reducing occupational stress in healthcare workers
1 Jun, 2023 | 12:18h | UTCNews Release: Stress-management interventions may help individual healthcare workers for at least a year – Cochrane Library
AHA Scientific Statement | Basic life support education for schoolchildren
25 May, 2023 | 11:37h | UTCNews Release: Learning to save lives can start as early as age 4, according to new scientific statement – American Heart Association
Top Things to Know: KIDS SAVE LIVES: Basic Life Support Education for Schoolchildren – American Heart Association
Perspective | Fake scientific papers are alarmingly common
24 May, 2023 | 13:18h | UTCFake scientific papers are alarmingly common – Science
Opinion Video | Questioning the reliability of nutrition science
23 May, 2023 | 13:02h | UTC
ChatGPT’s performance on radiology board exam: strengths and shortcomings
22 May, 2023 | 13:48h | UTCNews Release: ChatGPT passes radiology board exam – Radiological Society of North America
FDA warns of use of selective androgen receptor modulators (SARMs) among teens, young adults
10 May, 2023 | 16:00h | UTCCommentaries:
FDA issues warning for bodybuilding products marketed to teens, young adults – AAP News
Young Men Are Using Banned ‘SARM’ Supplements to Bulk Up, With Harmful Results – HealthDay
Video | Keeping up with the literature: special discussion of masking evidence
9 May, 2023 | 14:56h | UTCKeeping up with the literature | Special discussion of Masking Evidence
‘Too greedy’: mass walkout at global science journal over ‘unethical’ fees
8 May, 2023 | 13:19h | UTC‘Too greedy’: mass walkout at global science journal over ‘unethical’ fees – The Guardian
ChatGPT’s responses to patient questions rated higher for quality and empathy than physicians
2 May, 2023 | 14:00h | UTCChatGPT’s responses to patient questions rated higher for quality and empathy than physicians
Comparing Physician and Artificial Intelligence Chatbot Responses to Patient Questions Posted to a Public Social Media Forum – JAMA Internal Medicine (free for a limited period)
Commentaries:
How Chatbots and Large Language Model Artificial Intelligence Systems Will Reshape Modern Medicine: Fountain of Creativity or Pandora’s Box? – JAMA Internal Medicine (free for a limited period)
Commentary on Twitter (thread – click for more)
Here's what's under appreciated about Chat GPT paper?
PCP panel can be 2 to 5k
Doc in clinic 40 hours++ already
Doc not good at typing
Chat GPT can reply instantly
Chat GPT never fatigues
Can keep replying
Can reply day&night
Can read chart
Can type pleasantries, doc too busy 4— Vinay Prasad MD MPH (@VPrasadMDMPH) April 30, 2023
ADHD Medication Misuse | 25% of students in some US schools report nonmedical use for stimulant effect
26 Apr, 2023 | 14:21h | UTCNews Release: In some US schools, 1 in 4 students report misusing prescription stimulants – University of Michigan
Commentary on Twitter
Prescription stimulant misuse varies from 0% to >25% across US secondary schools. Schools with highest rates of stimulant therapy for #ADHD had 36% increased odds of misuse, offering targets for prevention and risk reduction strategies. https://t.co/4XHGpooBjz
— JAMA Network Open (@JAMANetworkOpen) April 18, 2023
Cohort Study | Beverage consumption and mortality among adults with type 2 diabetes
26 Apr, 2023 | 14:09h | UTCEditorial: Beverages and health outcomes in adults with type 2 diabetes – The BMJ
Commentary: Healthy Beverage Choices May Lower Mortality Risk in Adults with Diabetes – HCP Live