Study: Reductions in Acute Gastroenteritis–Related Hospitalizations and Associated Costs After Implementation of Rotavirus Vaccines

22Aug
2017

Study: Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding

22Aug
2017

Gastrointestinal safety of celecoxib versus naproxen in patients with cardiothrombotic diseases and arthritis after upper gastrointestinal bleeding (CONCERN): an industry-independent, double-blind, double-dummy, randomised trial – The Lancet (link to abstract – $ for full-text)

Source: ACP Journal Club

In this study, patients at high risk of both cardiovascular and gastrointestinal events who required concomitant aspirin and NSAID, celecoxib associated with a proton pump inhibitor led to less recurrent gastrointestinal bleeding when compared to naproxen associated with a proton pump inhibitor (5.6% vs 12.3%).

 

Guideline: Gastrointestinal Sarcomas (GIST)

22Aug
2017

Guideline: Living Donor Liver Transplant Recipient

22Aug
2017

Re-analysis of the USPSTF 2016 Evidence Report on Colorectal Cancer Screening

22Aug
2017

Guideline: Management of Inherited Polyposis Syndromes

22Aug
2017

Free Online Course: Anatomy of the Abdomen and Pelvis

21Aug
2017

Study: probiotics can prevent sepsis in newborns

17Aug
2017

New 8-Week Treatment Approved for All Hepatitis C Genotypes

17Aug
2017

New 8-Week Treatment Approved for All Hepatitis C Genotypes – Physician’s First Watch (free)

See also: FDA News Release

Standard treatment length was previously 12 weeks or more.

 

Effect of scheduled second-look endoscopy on peptic ulcer bleeding

16Aug
2017

Effect of scheduled second-look endoscopy on peptic ulcer bleeding: a prospective randomized multicenter trial – Gastrointestinal Endoscopy (link to abstract – $ for full-text)

Source: No Benefit of Second-Look Endoscopy After Endoscopic Hemostasis – Journal Watch ($)

“A single EGD with endoscopic hemostasis is not inferior to scheduled second-look endoscopy in terms of reduction in rebleeding rate of peptic ulcer bleeding. Repeat endoscopy would be helpful in the patients with unsatisfactory initial endoscopic hemostasis, use of NSAIDs, and larger amounts of transfused blood”

 

Cholera count reaches 500 000 in Yemen

15Aug
2017

Dexamethasone before bowel surgery reduces postoperative nausea and vomiting

15Aug
2017

Chronic Pancreatitis: Current Status and Challenges for Prevention and Treatment

15Aug
2017

Colorectal endoscopic submucosal dissection: patient selection and special considerations

15Aug
2017

Diarrhea after bariatric procedures: Diagnosis and therapy

11Aug
2017

Present and future of metastatic colorectal cancer treatment

11Aug
2017

Diet and Risk of Cholecystectomy

10Aug
2017

What treatment in 2017 for inoperable pancreatic cancers?

10Aug
2017

Treatment for Hepatitis C Virus by Community-Based Nonspecialist Providers

9Aug
2017

Acute mesenteric ischemia: guidelines

9Aug
2017

Gastro-Esophageal Reflux in Children

9Aug
2017

Transition of adolescent and young persons with chronic digestive diseases from paediatric to adult care

9Aug
2017

Raw milk and cheese cause 840 times more illnesses than pasteurized products

7Aug
2017

Nutrition support for adults: oral nutrition support, enteral tube feeding and parenteral nutrition

5Aug
2017

Antiemetics: American Society of Clinical Oncology Clinical Practice Guideline Update

3Aug
2017

Management of metastatic colorectal cancer patients

3Aug
2017

Clinical Practice Guidelines for Cryosurgery of Pancreatic Cancer

3Aug
2017

International consensus guidelines for the diagnosis and management of food protein–induced enterocolitis syndrome

3Aug
2017

European consensus conference on faecal microbiota transplantation in clinical practice

3Aug
2017

Low-FODMAP Diet May Improve Symptoms of Irritable Bowel Syndrome

1Aug
2017

World Hepatitis Day (28 July 2017) – World Health Organization Campaign

1Aug
2017

Acute-on-chronic liver failure: an update

1Aug
2017

Update on the Medical Management of Gastrointestinal Behçet’s Disease

1Aug
2017

Diagnostic autoantibodies for autoimmune liver diseases

28Jul
2017

Endoscopic ultrasound in oncology: An update of clinical applications in the gastrointestinal tract

28Jul
2017

Endoscopic recommendations for colorectal cancer screening and surveillance in patients with inflammatory bowel disease

28Jul
2017

Update in the assessment and management of intraductal papillary mucinous neoplasms of the pancreas

27Jul
2017

Advances in the Diagnosis and Management of Colonic Dysplasia in Patients With Inflammatory Bowel Disease

27Jul
2017

Guidelines for the understanding and management of pain in chronic pancreatitis

27Jul
2017

Critical Issues in Food Allergy: A National Academies Consensus Report

25Jul
2017

Development and Validation of the PREMM5 Model for Comprehensive Risk Assessment of Lynch Syndrome

23Jul
2017

Commentary and perspectives on graft-versus-host disease

23Jul
2017

Guidelines for the diagnosis and therapy of chronic pancreatitis

23Jul
2017

What carcinoembryonic antigen level should trigger further investigation during colorectal cancer follow-up?

23Jul
2017

What carcinoembryonic antigen level should trigger further investigation during colorectal cancer follow-up? A systematic review and secondary analysis of a randomised controlled trial – Health Technology Assessment (free)

Source: ACP Journal Wise ($)

“The results suggest that (1) CEA testing should not be used alone as a triage test; (2) in year 1, testing frequency should be increased (to monthly for 3 months and then every 2 months); (3) the threshold for investigating a single test result should be raised to 10 µg/l; (4) after the second CEA test, decisions to investigate further should be made on the basis of the trend in CEA levels; (5) the optimal threshold for investigating the CEA trend falls over time; and (6) continuing smokers should not be monitored with CEA testing”.

 

Guideline: Molecular Biomarkers for the Evaluation of Colorectal Cancer

22Jul
2017

Approach to cytomegalovirus infections in patients with ulcerative colitis

21Jul
2017

Reversal of liver cirrhosis: current evidence and expectations

21Jul
2017

Hepatology: Five Things Physicians and Patients Should Question

21Jul
2017

New European Society of Medical Oncology (ESMO) Updated Clinical Practice Guidelines

20Jul
2017

ECCO Position Statement on the Use of Biosimilars for Inflammatory Bowel Disease

18Jul
2017

Guideline: Neuroendocrine neoplasms of the small intestine and appendix

18Jul
2017

Guideline: Colorectal neuroendocrine neoplasms

18Jul
2017

Guideline: Pancreatic neuroendocrine neoplasms

18Jul
2017

Guideline: Gastroduodenal neuroendocrine neoplasms, including gastrinoma

18Jul
2017

Concise review: Irritable Bowel Syndrome

18Jul
2017

Update on the first-line treatment for Helicobacter pylori infection

18Jul
2017

Optimal diagnosis and disease activity monitoring of intestinal Behçet’s disease

18Jul
2017

Treatment and outcomes: medical and surgical treatment for intestinal Behçet’s disease

18Jul
2017

Prevalence, Pathogenesis, Diagnosis, and Management of Microscopic Colitis

18Jul
2017

Guideline: The management of intra-abdominal infections from a global perspective

17Jul
2017

Guideline: Constipation in children and young people: diagnosis and management

17Jul
2017

Hereditary pancreatic cancer: related syndromes and clinical perspective

16Jul
2017

NCCN Guidelines Insights: Antiemesis

13Jul
2017

Should we screen for cirrhosis?

13Jul
2017

Head To Head: Should we screen for cirrhosis? – The BMJ (free)

Pros and cons of screening high risk patients for liver cirrhosis.

 

Post-Surgical Complications

11Jul
2017

Post-Surgical Complications – emDocs (free)

Practical review of this common problem in the emergency department.

 

The relationship between eosinophilic esophagitis and esophageal cancer

11Jul
2017

The relationship between eosinophilic esophagitis and esophageal cancer – Diseases of The Esophagus (free)

An analysis of a large database of de-identified electronic medical records (EMRs) with over 40.000.000 patients found no association.

 

Guideline – Management of Crohn’s disease

7Jul
2017

Guideline – Management of ulcerative colitis

7Jul
2017

Cases of recurrent Clostridium difficile infection are increasing

7Jul
2017

Current Status of Immune Checkpoint Inhibitors in Gastrointestinal Cancers

7Jul
2017

Multidisciplinary approach of colorectal cancer liver metastases

7Jul
2017

Magnetic resonance imaging for diagnosis and neoadjuvant treatment evaluation in locally advanced rectal cancer

7Jul
2017

Immunotherapy in pancreatic cancer

7Jul
2017

Non-alcoholic fatty liver disease: An expanded review

7Jul
2017

Gut Microbiota as a Target for Preventive and Therapeutic Intervention against Food Allergy

7Jul
2017

Updates in Mirizzi syndrome

7Jul
2017

Pancreatic Ductal Adenocarcinoma: Current and Evolving Therapies

7Jul
2017

Risk of death among users of Proton Pump Inhibitors

5Jul
2017

Obesity and microbiota: an example of an intricate relationship

3Jul
2017

Treatment of severe alcoholic hepatitis

3Jul
2017

Functional Dyspepsia: Advances in Diagnosis and Therapy

3Jul
2017

Complications of Proton Pump Inhibitor Therapy

30Jun
2017

Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free)

Commentary: Complications of Proton Pump Inhibitor Therapy – PracticeUpdate (free registration required)

Related: Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND Proton Pump Inhibitors and Risk of Incident CKD and Progression to ESRD – Journal of the American Society of Nephrology (link to abstract – registration required for full text) AND Association of Proton Pump Inhibitors With Risk of Dementia: A Pharmacoepidemiological Claims Data Analysis – Jama Neurology (link to abstract – subscription required for full text)

The authors of this review argue that the observational studies that brought up the safety issues associated with PPIs (above studies, for example) are insufficient to establish causation and suggest a more balanced approach to PPI prescribing.

 

Colorectal polypectomy and endoscopic mucosal resection

29Jun
2017

Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection

26Jun
2017

Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)

Source: EvidenceAlerts (free resource to find articles of interest)

In this meta-analysis including 19 randomized trials, probiotics given within 2 days of the first antibiotic dose (more effective than if started later) reduced the risk of Clostridium difficile infection (CDI) by >50% in hospitalized adults. 1 case of CDI would be prevented for every 23−144 patients treated with probiotics when antibiotics are started. “There was no convincing evidence of superior efficacy for any of the tested probiotic formulations, delivery methods (drink or capsule), or probiotic doses”.

 

Spotlight on FODMAPs for IBS

25Jun
2017

Diagnostic Accuracy of Fecal Immunochemical Test in Patients at Increased Risk for Colorectal Cancer

25Jun
2017

ACG and CAG Clinical Guideline: Management of Dyspepsia

23Jun
2017

Guidelines for the Management of Cancer of the Colon, Rectum and Anus

23Jun
2017

Clinical effects of antivirals for hepatitis C: context is critical

23Jun
2017

Update on anti-TNF agents and other new drugs for IBD

23Jun
2017

Aspirin and other NSAIDs and colorectal cancer survival

21Jun
2017

Timing of Aspirin and Other Nonsteroidal Anti-Inflammatory Drug Use Among Patients With Colorectal Cancer in Relation to Tumor Markers and Survival – Journal of Clinical Oncology (link to abstract – $ for full-text)

Commentary: Study Informs NSAID Benefit in Colon Cancer – MedPage Today (free registration required)

Observational data suggests a benefit for individuals with KRAS wild-type tumors

 

New colorectal cancer screening guidelines

20Jun
2017

Surgeon Variation in Complications With Minimally Invasive and Open Colectomy

20Jun
2017

Surgeon Variation in Complications With Minimally Invasive and Open Colectomy: Results From the Michigan Surgical Quality Collaborative – JAMA Surgery (free) (RT @MaryDixonWoods see Tweet)

Surgeon-level variation in complications among surgeons was nearly twice as great for Minimally Invasive Colectomy than for Open Colectomy, implying a need for improved training in adoption of minimally invasive techniques.

 

A Good News Story About Diarrhea

20Jun
2017

Development and validation of risk prediction equations to estimate survival in patients with colorectal cancer

19Jun
2017

Guidelines for gastro-entero-pancreatic neuroendocrine neoplasms

19Jun
2017

Asia–Pacific clinical practice guidelines on the management of hepatocellular carcinoma

16Jun
2017

Pancreatic Adenocarcinoma: Improving Prevention and Survivorship

16Jun
2017

Inflammatory Bowel Disease in Childhood and Adolescence

16Jun
2017

Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events

15Jun
2017
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