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Family Medicine

Cohort Study | Vegetarian diet linked to elevated hip fracture risk; BMI plays a partial role

9 Aug, 2023 | 15:16h | UTC

Risk of hip fracture in meat-eaters, pescatarians, and vegetarians: a prospective cohort study of 413,914 UK Biobank participants – BMC Medicine

 


M-A | Community-based interventions using holistic assessment and care planning improve independent living in older adults

9 Aug, 2023 | 15:13h | UTC

Complex interventions for improving independent living and quality of life amongst community-dwelling older adults: a systematic review and meta-analysis – Age and Ageing

 


Podcast | Knee pain pearls

9 Aug, 2023 | 15:08h | UTC

#406 Kneedful Things: Knee Pain 201 with Dr. Ted Parks – The Curbsiders

 


M-A | Nearly 37% of elderly outpatients are at risk due to potentially inappropriate medication use

8 Aug, 2023 | 13:37h | UTC

Prevalence of Use of Potentially Inappropriate Medications Among Older Adults Worldwide: A Systematic Review and Meta-Analysis – JAMA Network Open

 


Perspective | Will unpredictable side effects dim the promise of new Alzheimer’s drugs?

8 Aug, 2023 | 13:30h | UTC

Will unpredictable side effects dim the promise of new Alzheimer’s drugs? – Science (a few articles per month are free)

Related:

RCT | Donanemab slows early symptomatic Alzheimer’s progression, but raises serious safety concerns

RCT | Lecanemab slows cognitive decline in early Alzheimer’s disease but raises safety concerns

 


Cohort Study | Habitual calcium supplementation linked to higher CVD incidence and mortality in diabetics

8 Aug, 2023 | 13:24h | UTC

Associations of Habitual Calcium Supplementation With Risk of Cardiovascular Disease and Mortality in Individuals With and Without Diabetes – Diabetes Care (link to abstract – $ for full-text)

Related: The Evidence and Controversy Between Dietary Calcium Intake and Calcium Supplementation and the Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis of Cohort Studies and Randomized Controlled Trials – Journal of the American College of Nutrition

 

Commentary on Twitter

 


NICE Updated Guideline | Venous thromboembolic diseases

7 Aug, 2023 | 15:05h | UTC

Venous thromboembolic diseases: diagnosis, management and thrombophilia testing  – National Institute for Health and Care Excellence

 


Review | Management of worsening heart failure with reduced ejection fraction

7 Aug, 2023 | 15:03h | UTC

Management of Worsening Heart Failure With Reduced Ejection Fraction: JACC Focus Seminar 3/3 – Journal of the American College of Cardiology

 

Commentary on Twitter

 


Opinion | Regulating direct-to-consumer polygenic risk scores

7 Aug, 2023 | 14:59h | UTC

Regulating Direct-to-Consumer Polygenic Risk Scores – JAMA (free for a limited period)

 


Perspective | The paradoxical decline of geriatric medicine as a profession

7 Aug, 2023 | 14:57h | UTC

The Paradoxical Decline of Geriatric Medicine as a Profession – JAMA (free for a limited period)

 

Commentary on Twitter

 


Review | Diabetes of the exocrine pancreas: implications for pharmacological management

7 Aug, 2023 | 14:25h | UTC

Diabetes of the Exocrine Pancreas: Implications for Pharmacological Management – Drugs

 


Study | Gastric bypass linked to increased risk of non-alcohol substance use disorder

7 Aug, 2023 | 14:23h | UTC

Non-alcohol substance use disorder after bariatric surgery in the prospective, controlled Swedish Obese Subjects study – Obesity

News Release: Gastric bypass surgery associated with non-alcohol substance use disorder – Obesity – The Obesity Society

 


USPSTF | Reaffirming the importance of folic acid to all women planning to or who could become pregnant to prevent neural tube defects

4 Aug, 2023 | 12:15h | UTC

Folic Acid Supplementation to Prevent Neural Tube Defects: US Preventive Services Task Force Reaffirmation Recommendation Statement – JAMA

Evidence Report: Folic Acid Supplementation to Prevent Neural Tube Defects: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Patient Page: Folic Acid to Prevent Neural Tube Defects – JAMA

 

Commentary on Twitter

 


RCT | 52-week antidepressant adjunctive therapy did not lead to a statistically significant benefit over 8-week therapy in bipolar I depression

4 Aug, 2023 | 12:11h | UTC

Duration of Adjunctive Antidepressant Maintenance in Bipolar I Depression – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Modern antidepressants may reduce risk of relapse for patients with bipolar depression – University of British Columbia

 

Commentary on Twitter

 


Review | Primary aldosteronism: a pragmatic approach to diagnosis and management

4 Aug, 2023 | 12:06h | UTC

Primary Aldosteronism: A Pragmatic Approach to Diagnosis and Management – Mayo Clinic Proceedings

 


KDIGO Conference | Managing the symptom burden associated with maintenance dialysis

4 Aug, 2023 | 12:02h | UTC

Managing the symptom burden associated with maintenance dialysis: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference – Kidney International

News Release: KDIGO Announces Publication of “Managing the Symptom Burden Associated with Maintenance Dialysis”

 

Commentary on Twitter

 


M-A | Antenatal corticosteroid exposure linked to negative outcomes in term-born infants

4 Aug, 2023 | 11:59h | UTC

The proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes: systematic review and meta-analysis of 1.6 million infants – The BMJ

Related Study: Association between antenatal corticosteroids and risk of serious infection in children: nationwide cohort study – The BMJ

Editorial: Antenatal corticosteroids and longer term outcomes – The BMJ

News Releases:

New studies shed more light on potential risks of antenatal steroids – BMJ Newsroom

Researchers find drugs that reduce infant death may lead to long-term health issues – McMaster University

 


Cohort Study | Antenatal corticosteroid exposure associated with increased incidence of pediatric serious infection

4 Aug, 2023 | 11:57h | UTC

Association between antenatal corticosteroids and risk of serious infection in children: nationwide cohort study – The BMJ

Related Study: The proportions of term or late preterm births after exposure to early antenatal corticosteroids, and outcomes: systematic review and meta-analysis of 1.6 million infants – The BMJ

Editorial: Antenatal corticosteroids and longer term outcomes – The BMJ

 


Review | Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management

4 Aug, 2023 | 11:49h | UTC

Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management – Cleveland Clinic Journal of Medicine

 


ACP Guidance | Asymptomatic CRC screening advised from age 50 with fecal occult blood test every 2 years or colonoscopy every 10 years

3 Aug, 2023 | 13:48h | UTC

Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults: A Guidance Statement From the American College of Physicians – Annals of Internal Medicine

News Release: ACP issues updated guidance for colorectal cancer screening of asymptomatic adults – American College of Physicians

Commentary: Start screening for colorectal cancer at age 50 years, ACP suggests – ACP Internist

Summary for Patients: Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults – Annals of Internal Medicine

 


RCT – 2ry analysis | Omega-3 supplementation linked to increased AF risk in post-MI patients

3 Aug, 2023 | 13:45h | UTC

Omega-3 fatty acid supplements and risk of atrial fibrillation and ‘micro-atrial fibrillation’: A secondary analysis from the OMEMI trial – Clinical Nutrition

Related:

M-A: Omega-3 fatty acids supplementation is associated with increased risk of atrial fibrillation.

M-A: Omega-3 fatty acids supplementation increases the risk of atrial fibrillation in patients with lipid disorders.

More data suggests no cardiovascular benefit from Omega-3 supplementation – secondary analysis of STRENGHT trial did not show an association between achieved Omega-3 fatty acid levels and major adverse cardiovascular outcomes in patients with high cardiovascular risk.

RCT: Omega-3 supplements do not reduce cardiovascular events in elderly patients after myocardial infarction

#AHA20 – Randomized trial: High-dose Omega-3 fatty acids did not reduce the risk of cardiac events in patients at high cardiovascular risk

Meta-Analysis of Randomized Trials: Little Benefit from Omega-3 Intake to Reduce Cardiovascular Disease Risk

 

Commentary from the author on Twitter (thread – click for more)

 


Cohort Study | Increased mortality rates in delirium tremens patients versus alcohol withdrawal or dependence

3 Aug, 2023 | 13:35h | UTC

Mortality and alcohol-related morbidity in patients with delirium tremens, alcohol withdrawal state or alcohol dependence in Norway: A register-based prospective cohort study – Addiction

 


Study | Increasing alcohol-related mortality rates in US women, 1999-2020

3 Aug, 2023 | 13:20h | UTC

Trends in Alcohol-Related Deaths by Sex in the US, 1999-2020 – JAMA Network Open

Commentary: As alcohol-related deaths rise in the US, women are increasingly at risk, study shows – CNN

 


USPSTF Draft Statement | Insufficient evidence for screening children under 5 years for speech and language delay

2 Aug, 2023 | 14:13h | UTC

Speech and Language Delay and Disorders in Children: Screening – U.S. Preventive Services Task Force

Commentary:

USPSTF issues statement on speech, language disorder screenings for all children up to 5 years – Contemporary Pediatrics

USPSTF: Evidence Lacking for Screening for Speech Delays in Young Children – HealthDay

 


Perspective | The most important trial in modern cardiology (Critical appraisal of the ISCHEMIA trial)

2 Aug, 2023 | 14:11h | UTC

Chapter 3: The Most Important Trial in Modern Cardiology – Sensible Medicine

See also:

Chapter 1: What Does it Mean to Discover a Coronary Blockage? – By Dr John Mandrola

Chapter 2: On the meaning of a coronary blockage – By Dr John Mandrola

Related/Original Articles:

ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease

ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease

ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease

ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease

Follow-up of the ISCHEMIA trial | Similar survival after invasive vs. conservative management of stable coronary disease.

ISCHEMIA Trial 2ry Analysis | Patients with CCD and daily/weekly angina seem to benefit most from complete revascularization

 


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