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Family Medicine

Unvaccinated pregnant people are at higher risk for Covid complications and newborn deaths.

14 Jan, 2022 | 08:44h | UTC

Unvaccinated pregnant people are at higher risk for Covid complications and newborn deaths – STAT

Original Study: SARS-CoV-2 infection and COVID-19 vaccination rates in pregnant women in Scotland – Nature Medicine

 

COVID vaccines safely protect pregnant people: the data are in.

14 Jan, 2022 | 08:43h | UTC

COVID vaccines safely protect pregnant people: the data are in – Nature

Related:

COVID-19 vaccination in pregnancy—number needed to vaccinate to avoid harm.

A case-controlled study showed Covid-19 vaccination during early pregnancy was not associated with increased risk of first-trimester miscarriage.

Editorial: Covid-19 treatments and vaccines must be evaluated in pregnancy.

AstraZeneca vaccination not linked to reduced fertility rates and adverse birth outcomes.

Cohort study: Vaccinated pregnant patients had 90% lower risk of severe or critical Covid-19 compared with unvaccinated pregnant patients.

Two observational studies suggest spontaneous abortion is not increased following COVID-19 mRNA vaccination during pregnancy.

Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.

5 Crucial Things to Know About COVID-19 Vaccines and Pregnancy.

CDC Guidance: Pregnant people should be vaccinated against COVID-19.

ACOG and SMFM Recommend COVID-19 Vaccination for Pregnant Individuals – “ACOG encourages its members to enthusiastically recommend vaccination to their patients.”

Cohort study: Pfizer/BioNTech COVID vaccine associated with 78% lower risk of Covid-19 in pregnancy.

 

Fluvoxamine for Covid-19: What Prescribers and Pharmacists Need to Know.

14 Jan, 2022 | 08:37h | UTC

Fluvoxamine: What Prescribers and Pharmacists Need to Know – Covid-19 Advisory for Ontario

Related:

Fluvoxamine for the early treatment of SARS-CoV-2 Infection: a review of current evidence.

RCT: Early treatment with fluvoxamine reduced the risk of emergency care and hospitalization among patients with COVID-19.

[Preprint] RCT: Fluvoxamine reduced the risk for ER visits and hospitalization among patients with Covid-19.

Opinion | Could this be our first effective, inexpensive, widely available outpatient treatment for COVID-19? (It’s fluvoxamine).

Preliminary study shows fluvoxamine may reduce clinical deterioration in outpatients with symptomatic COVID-19

 

Commentary on Twitter

 

Perioperative cardiovascular considerations prior to elective noncardiac surgery in patients with a history of Covid-19.

14 Jan, 2022 | 08:39h | UTC

Perioperative Cardiovascular Considerations Prior to Elective Noncardiac Surgery in Patients With a History of COVID-19 – JAMA Surgery

Related:

Guideline: SARS‐CoV‐2 infection, COVID‐19 and timing of elective surgery

Study from 116 countries suggests surgery should be delayed for at least seven weeks following a COVID-19 diagnosis to reduce mortality risk

BJS commission on surgery and perioperative care post-COVID-19.

The risk of postoperative complications following major elective surgery in active or resolved COVID-19 in the United States – Major, elective surgery 0–4 weeks after Covid-19 is associated with greatly increased risk of postoperative complications; surgery performed 4–8 weeks after infection is still associated with an increased risk of pneumonia.

ASA Guidance: Preoperative testing for COVID-19 is essential, regardless of vaccination.

Position statement: Perioperative management of post-COVID-19 surgical patients.

Cohort study: Postoperative in-hospital mortality of patients with COVID-19 infection was more than double that in patients without COVID-19

 

Perspective: Omicron is forcing us to rethink mild COVID.

14 Jan, 2022 | 08:30h | UTC

Omicron Is Forcing Us to Rethink Mild COVID – The Atlantic

 

RCT: Colchicine did not significantly reduce the need for intubation or 28-day mortality in patients hospitalized with Covid-19.

14 Jan, 2022 | 08:35h | UTC

Effect of Colchicine vs Usual Care Alone on Intubation and 28-Day Mortality in Patients Hospitalized With COVID-19: A Randomized Clinical Trial – JAMA Network Open

Related:

M-A: Colchicine doesn’t lessen COVID-19 severity or stave off risk of death.

RECOVERY Trial: In patients admitted to hospital with COVID-19, Colchicine did not reduce 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death.

[Preprint] PRINCIPLE RCT: Colchicine does not improve time to recovery in outpatients with Covid-19 at higher risk of complications.

COLCORONA RCT: Colchicine for community-treated patients with COVID-19 – findings suggest it may lower death and hospital admission rates, but further studies are required.

[Preprint] RECOVERY Trial: Colchicine does not improve outcomes in patients admitted to hospital with COVID-19.

 

Commentary on Twitter

 

Review: Migraine.

14 Jan, 2022 | 08:16h | UTC

Migraine – Nature Reviews Disease Primers (if the link is paywalled, try this one)

Infographic: Migraine (if the link is paywalled, try this one)

 

M-A: Combined oral contraceptives may improve overall premenstrual symptomatology but are not helpful for premenstrual depressive symptoms.

14 Jan, 2022 | 07:49h | UTC

Efficacy of combined oral contraceptives for depressive symptoms and overall symptomatology in premenstrual syndrome: pairwise and network meta-analysis of randomized trials – American Journal of Obstetrics & Gynecology

Commentary: ‘Optimal’ treatment for premenstrual depressive symptoms remains elusive – Healio (free registration required)

 

Observational study in adolescents showed the Pfizer-BioNTech vaccine had an overall effectiveness of 94% against hospitalization and 98% against critical Covid-19.

13 Jan, 2022 | 09:00h | UTC

Effectiveness of BNT162b2 Vaccine against Critical Covid-19 in Adolescents – New England Journal of Medicine

Editorial: Sparing of Severe Covid-19 in Vaccinated Adolescents – New England Journal of Medicine

 

Study shows COVID-19 vaccines offer lasting protection against hospitalization and death.

13 Jan, 2022 | 09:01h | UTC

Duration of Protection against Mild and Severe Disease by Covid-19 Vaccines – New England Journal of Medicine

News Release: Study shows COVID-19 vaccines offer lasting protection – University of North Carolina at Chapel Hill

 

An observational study in South Africa estimates the Pfizer vaccine had an effectiveness of 70% against hospitalization for Covid-19 caused by the omicron variant.

13 Jan, 2022 | 08:56h | UTC

Effectiveness of BNT162b2 Vaccine against Omicron Variant in South Africa – New England Journal of Medicine

Commentary: BNT162b2 still effective, but less so, against Omicron – HealthDay

 

The COVID generation: how is the pandemic affecting kids’ brains?

13 Jan, 2022 | 08:53h | UTC

The COVID generation: how is the pandemic affecting kids’ brains? – Nature

 

A clinical case definition of post-COVID-19 condition by a Delphi consensus.

13 Jan, 2022 | 08:45h | UTC

A clinical case definition of post-COVID-19 condition by a Delphi consensus – The Lancet Infectious Diseases

 

Commentary on Twitter

 

Review: Diagnosis and treatment of sexually transmitted infections.

13 Jan, 2022 | 08:38h | UTC

Diagnosis and Treatment of Sexually Transmitted Infections: A Review – JAMA (free for a limited period)

 

The year in cardiovascular medicine 2021: diabetes and metabolic disorders.

13 Jan, 2022 | 08:33h | UTC

The year in cardiovascular medicine 2021: diabetes and metabolic disorders – European Heart Journal

 

The year in cardiovascular medicine 2021: dyslipidemia.

13 Jan, 2022 | 08:30h | UTC

The year in cardiovascular medicine 2021: dyslipidemia – European Heart Journal

 

M-A: Intermittent Fasting and Obesity-Related Health Outcomes.

13 Jan, 2022 | 08:22h | UTC

Intermittent Fasting and Obesity-Related Health Outcomes: An Umbrella Review of Meta-analyses of Randomized Clinical Trials – JAMA Network Open

 

Cohort Study: In preterm premature rupture of membranes at 24-31 weeks, antibiotic prophylaxis based on third-generation cephalosporin may be associated with improved perinatal outcomes compared to amoxicillin.

13 Jan, 2022 | 08:10h | UTC

Antibiotic prophylaxis in preterm premature rupture of membranes at 24-31 weeks’ gestation: perinatal and 2-year outcomes in the EPIPAGE-2 cohort – BJOG (link to abstract – $ for full-text)

 

International study identifies predictors of severe outcomes in children with COVID-19.

12 Jan, 2022 | 09:05h | UTC

News Release: International study identifies predictors of severe outcomes in children with COVID-19 – University of Calgary

Original Study: Outcomes of SARS-CoV-2–Positive Youths Tested in Emergency Departments: The Global PERN–COVID-19 Study – JAMA Network Open

 

Statement on potential drug-drug interactions between Ritonavir-boosted Nirmatrelvir (Paxlovid) and concomitant medications; antiarrhythmics, oral anticoagulants, immunosuppressants, anticonvulsants, antineoplastics, and neuropsychiatric drugs are among the drugs of concern.

12 Jan, 2022 | 09:09h | UTC

The COVID-19 Treatment Guidelines Panel’s Statement on Potential Drug-Drug Interactions Between Ritonavir-Boosted Nirmatrelvir (Paxlovid) and Concomitant Medications – NIH COVID-19 Treatment Guidelines Panel

Commentaries:

Pfizer antiviral pills may be risky with other medications – NBC News

The New COVID-19 Pill, Paxlovid, Interacts with Many Medications: Cardiac Patients Take Note – The Skeptical Cardiologist

See also: What’s New in the Guidelines – NIH COVID-19 Treatment Guidelines

 

Podcast: Long COVID Pearls.

12 Jan, 2022 | 09:04h | UTC

#315 Long COVID with Dr. Monica Verduzco-Gutierrez – The Curbsiders

 

RCT: Endoscopic sinus surgery with medical therapy vs. medical therapy alone for chronic rhinosinusitis with nasal polyps.

12 Jan, 2022 | 08:51h | UTC

Endoscopic sinus surgery with medical therapy versus medical therapy for chronic rhinosinusitis with nasal polyps: a multicentre, randomised, controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: Among patients younger than 21 years of age with provoked thromboembolism, anticoagulation for 6 weeks was non-inferior vs. 12 weeks on the risk of recurrence and bleeding events.

12 Jan, 2022 | 08:53h | UTC

Effect of Anticoagulant Therapy for 6 Weeks vs 3 Months on Recurrence and Bleeding Events in Patients Younger Than 21 Years of Age With Provoked Venous Thromboembolism: The Kids-DOTT Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Duration of Anticoagulant Treatment for Acute Provoked Venous Thromboembolism in Pediatric Patients – JAMA (free for a limited period)

 

Cohort Study: Higher consumption of olive oil linked to lower risk of cardiovascular, cancer, and all-cause mortality.

12 Jan, 2022 | 08:41h | UTC

Consumption of Olive Oil and Risk of Total and Cause-Specific Mortality Among U.S. Adults – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries:

Higher olive oil intake associated with lower risk of CVD mortality – American College of Cardiology

Higher Olive Oil Intake May Be Associated With Lower Risk of CVD Mortality – American College of Cardiology

 

Consequences of a diagnostic label: A systematic scoping review and thematic framework.

12 Jan, 2022 | 08:37h | UTC

Consequences of a Diagnostic Label: A Systematic Scoping Review and Thematic Framework – Frontiers in Public Health

 

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