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Family Medicine

SR | Limited evidence for vitamin and mineral supplements in delaying dementia in people with mild cognitive impairment

7 Jun, 2023 | 14:09h | UTC

Vitamin and mineral supplementation for preventing dementia or delaying cognitive decline in people with mild cognitive impairment – Cochrane Library

 

Commentary on Twitter

 


AHA Scientific Advisory | Digital technologies in cardiac rehabilitation

7 Jun, 2023 | 14:23h | UTC

Digital Technologies in Cardiac Rehabilitation: A Science Advisory From the American Heart Association – Circulation

Top Things to Know: Digital Technologies in CR – American Heart Association

 


JACC Scientific Statement | Remote monitoring for heart failure management at home

7 Jun, 2023 | 14:00h | UTC

Remote Monitoring for Heart Failure Management at Home – Journal of the American College of Cardiology

 

Commentary on Twitter

 


M-A | Advance care planning for frail elderly: are we missing a golden opportunity?

7 Jun, 2023 | 13:53h | UTC

Advance care planning for frail elderly: are we missing a golden opportunity? A mixed-method systematic review and meta-analysis – BMJ Open

 


Guideline Series | Prevention and management of diabetes-related foot disease

7 Jun, 2023 | 13:41h | UTC

Practical guidelines on the prevention and management of diabetes-related foot disease (IWGDF 2023 update) – Diabetes/Metabolism Research and Reviews

Definitions and criteria for diabetes-related foot disease (IWGDF 2023 update)

Guidelines on the classification of foot ulcers in people with diabetes (IWGDF 2023 update)

Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update)

Guidelines on offloading foot ulcers in persons with diabetes (IWGDF 2023 update)

Guidelines on the diagnosis and treatment of active Charcot neuro-osteoarthropathy in persons with diabetes mellitus (IWGDF 2023)

Diagnosis and treatment of active charcot neuro-osteoarthropathy in persons with diabetes mellitus: A systematic review

Guidelines on the diagnosis and treatment of foot infection in persons with diabetes – International Working Group on the Diabetic Foot

Prevention of foot ulcers in persons with diabetes at risk of ulceration: A systematic review and meta-analysis

 


RCT | Immediate vs. delayed sequential bilateral cataract surgery: non-inferior in safety, higher cost-effectiveness

6 Jun, 2023 | 14:41h | UTC

Safety, effectiveness, and cost-effectiveness of immediate versus delayed sequential bilateral cataract surgery in the Netherlands (BICAT-NL study): a multicentre, non-inferiority, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

News Release: Cataract surgery: two-sided treatment better than one-by-one approach – Maastricht University

 


RCT | Tirzepatide outperforms insulin glargine in HbA1c reduction and weight loss in type 2 diabetes

6 Jun, 2023 | 14:39h | UTC

Tirzepatide versus insulin glargine as second-line or third-line therapy in type 2 diabetes in the Asia-Pacific region: the SURPASS-AP-Combo trial – Nature Medicine

 

Commentary on Twitter

 


Adrenaline auto-injector prescription for patients at risk of anaphylaxis: BSACI guidance for primary care

6 Jun, 2023 | 14:28h | UTC

Adrenaline auto-injector prescription for patients at risk of anaphylaxis: BSACI guidance for primary care – Clinical & Experimental Allergy

 


Podcast | Insulin, type 2 diabetes, and hypoglycemia

6 Jun, 2023 | 14:25h | UTC

#397: Insulin, Type 2 Diabetes, Fanny Packs, and Hypoglycemia with Dr. Jeff Colburn – The Curbsiders

 


Podcast | Hypopigmented and depigmented skin lesions in pediatrics

6 Jun, 2023 | 14:24h | UTC

#84: Hypopigmented & Depigmented Skin Lesions: An En-LIGHT-ening Review – The Cribsiders

 


Podcast | Ascend your understanding of pelvic inflammatory disease

6 Jun, 2023 | 14:23h | UTC

#83: Ascend Your Understanding of Pelvic Inflammatory Disease (PID) – The Cribsiders

 


Brief Review | What BP target is appropriate for pregnant patients with mild chronic hypertension?

6 Jun, 2023 | 14:20h | UTC

What BP target is appropriate for pregnant patients with mild chronic hypertension? – Journal of Family Practice

 


Adrenal failure: an evidence-based diagnostic approach

6 Jun, 2023 | 14:16h | UTC

Adrenal Failure: An Evidence-Based Diagnostic Approach – Diagnostics

 


Systematic Review | Impact of physical therapies on pain, function, and life quality in myofascial pain syndrome

6 Jun, 2023 | 14:07h | UTC

The effect of therapeutic physical modalities on pain, function, and quality of life in patients with myofascial pain syndrome: a systematic review – BMC Musculoskeletal Disorders

 


RCT | Noninferiority shown between DOACs and LMWH for recurrent VTE prevention in cancer patients

5 Jun, 2023 | 13:50h | UTC

Summary: This unblinded, pragmatic, noninferiority randomized clinical trial aimed to assess the efficacy of direct oral anticoagulants (DOACs) against low-molecular-weight heparin (LMWH) in preventing recurrent venous thromboembolism (VTE) in patients with cancer. The study included 671 patients from 67 oncology centers, with a new clinical or radiological diagnosis of VTE.

Participants were randomly assigned to receive either a DOAC or LMWH for 6 months, and treating physicians selected and prescribed the drugs based on considerations like availability and drug-drug interactions. The primary outcome was the rate of recurrent VTE at 6 months. Findings revealed that the DOAC group had a recurrent VTE rate of 6.1% as compared to 8.8% in the LMWH group, showing noninferiority. Both groups had statistically similar rates of major bleeding and severe adverse events.

This pragmatic study included patients with advanced cancer and brain metastases, impaired performance status, and reduced liver or kidney function, making it more representative of routine oncology practice. Moreover, patient adherence to DOAC treatment was significantly higher than to LMWH. Nevertheless, the study had limitations, including the lack of blinding and underrepresentation of certain racial and ethnic groups.

In conclusion, this trial suggests that DOACs were noninferior to LMWH for preventing recurrent VTE in patients with cancer over a 6-month follow-up period, supporting the use of DOACs in this population for VTE prevention. Further research is needed to confirm these results and investigate long-term outcomes.

Article: Direct Oral Anticoagulants vs Low-Molecular-Weight Heparin and Recurrent VTE in Patients With Cancer: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual abstract

 

Commentary on Twitter

 


Review | Prevention of venous thromboembolism in patients with cancer

5 Jun, 2023 | 13:48h | UTC

Prevention of venous thromboembolism in patients with cancer – The BMJ

 


Cohort Study | Overweight or obesity in early and middle adulthood linked to higher gastrointestinal cancer risk

5 Jun, 2023 | 13:34h | UTC

Analysis of Body Mass Index in Early and Middle Adulthood and Estimated Risk of Gastrointestinal Cancer – JAMA Network Open

Editorial: Obesity and Gastrointestinal Cancer: A Life Course Perspective – JAMA Network Open

Commentary: Association Between Overweight/Obesity and Risk of Gastrointestinal Cancer – The ASCO Post

 


Cohort Study | Cannabis use disorder linked to increased risk of depression and bipolar disorder

5 Jun, 2023 | 13:26h | UTC

Cannabis Use Disorder and Subsequent Risk of Psychotic and Nonpsychotic Unipolar Depression and Bipolar Disorder – JAMA Psychiatry (link to abstract – $ for full-text)

Author Interview: Cannabis Use Disorder and Subsequent Risk of Unipolar Depression and Bipolar Disorder

Commentary: Expert reaction to study of cannabis use disorder, bipolar disorder, and depression – Science Media Centre

 


M-A | Efficacy and safety of duloxetine in chronic musculoskeletal pain

5 Jun, 2023 | 13:09h | UTC

Efficacy and safety of duloxetine in chronic musculoskeletal pain: a systematic review and meta-analysis – BMC Musculoskeletal Disorders

 


Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050

2 Jun, 2023 | 12:34h | UTC

Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021 – The Lancet Rheumatology

Editorial: The global epidemic of low back pain – The Lancet Rheumatology

News Releases:

New study shows low back pain is the leading cause of disability around the world – Institute for Health Metrics and Evaluation

In 2050, over 800 million people globally estimated to be living with back pain – The University of Sidney

 

Commentary on Twitter

 


ACR Guideline for exercise, rehabilitation, diet, and additional integrative interventions for rheumatoid arthritis

2 Jun, 2023 | 12:33h | UTC

2022 American College of Rheumatology Guideline for Exercise, Rehabilitation, Diet, and Additional Integrative Interventions for Rheumatoid Arthritis – Arthritis Care & Research

Editorial: Patient Perspectives on the 2022 American College of Rheumatology Guideline for Exercise, Rehabilitation, Diet, and Additional Integrative Interventions for Rheumatoid Arthritis – Arthritis Care & Research

News Release: New Guideline Introduces Recommendations for Integrative Approach to RA Treatment – American College of Rheumatology

 


Systematic Review | Bupropion and nortriptyline: an assessment of their effectiveness in smoking cessation

2 Jun, 2023 | 12:28h | UTC

Antidepressants for smoking cessation – Cochrane Library

 


Systematic review | Analgesic use in sports

2 Jun, 2023 | 12:17h | UTC

Analgesic Use in Sports: Results of a Systematic Literature Review – Deutsches Ärzteblatt International

 


Review | Subclinical hypothyroidism: let the evidence be your guide

2 Jun, 2023 | 12:08h | UTC

Subclinical hypothyroidism: Let the evidence be your guide – Journal of Family Practice

 


Review | Medication-assisted recovery for opioid use disorder

2 Jun, 2023 | 12:03h | UTC

Medication-assisted recovery for opioid use disorder: A guide – Journal of Family Practice

 


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