Family Medicine

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ (free)

Related: Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention (link to abstract and commentary) AND NICE Guideline: Vitamin D Supplementation (free)

Vitamin D supplementation was not associated with all-cause mortality, cardiovascular mortality, or non-cancer, non-cardiovascular mortality. However, Vitamin D supplementation statistically significantly reduced the risk of cancer death by 16%.

 

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Comparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary: Don’t Use More Than 400 mg of Ibuprofen for Pain Control – NEJM Journal Watch (free for a limited period)

 

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Long-term adverse events after sleeve gastrectomy or gastric bypass: a 7-year nationwide, observational, population-based, cohort study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentary: Death Risk Drops After Bariatric Surgery in Obese Patients – MedPage Today (free registration required)

Related Research: Association of Bariatric Surgery vs Usual Care Obesity Management With All-Cause Mortality (free study and commentaries)

 

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Medications Affecting the Biochemical Conversion to Type 2 Diabetes: A Systematic Review and Meta-Analysis – The Journal of Clinical Endocrinology & Metabolism (free)

α-Glucosidase inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, metformin, orlistat, phentermine/topiramate, and pioglitazone significantly reduced the risk of biochemical conversion to T2DM, whereas statins and nateglinide increased the risk”

 


Too Much Medicine: Not Enough trust?

11 Aug, 2019 | 22:18h | UTC

Too Much Medicine: Not Enough trust? – Journal of Medical Ethics (free)

 

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Three versus five days of pivmecillinam for community-acquired uncomplicated lower urinary tract infection: A randomised, double-blind, placebo-controlled superiority trial – EClinicalMedicine (free)

 

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Perioperative Management of Patients With Atrial Fibrillation Receiving a Direct Oral Anticoagulant – JAMA Internal Medicine (free for a limited period)

Commentary: Study Sheds Light on Stopping and Resuming DOACs in Afib Patients Undergoing Surgery – NEJM Journal Watch (free)

“The DOAC regimens were omitted for 1 day before a low–bleeding-risk procedure and 2 days before a high–bleeding-risk procedure. The DOAC regimens were resumed 1 day after a low–bleeding-risk procedure and 2 to 3 days after a high–bleeding-risk procedure.”

 

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Potential Medicare Savings From Generic Substitution and Therapeutic Interchange of ACE Inhibitors and Angiotensin-II-Receptor Blockers – JAMA Internal Medicine (free for a limited period)

“By maximizing generic substitution and therapeutic interchange, Medicare could have saved approximately $676 million (89.6%) in 2016 and 2017 of the total $754 million spent on these brand-name ACEIs and ARBs during those 2 years”.

 


Alex Nowbar’s journal review, 5 August 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Oral antihypertensive regimens (nifedipine retard, labetalol, and methyldopa) for management of severe hypertension in pregnancy: an open-label, randomised controlled trial – The Lancet (free)

Commentary: Oral regimen management of acute hypertension in pregnancy – The Lancet (free)

 

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Consensus on Non-cardiac Chest Pain

1 Aug, 2019 | 08:52h | UTC

New Protocol For HIV Prevention Drug Reduces The Number Of Pills Required – Kaiser Health News (free)

Related: British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject) AND USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection (free guideline and commentaries)

“both organizations now endorse a strategy that requires taking just four pills timed to a specific sexual encounter — two within two to 24 hours before sex and one on each of the two following days… The new strategy, called “2-1-1” or “on-demand” PrEP, is becoming popular overseas but has gotten little traction in the United States thus far.”

 


Association of Early Interventions With Birth Outcomes and Child Linear Growth in Low-Income and Middle-Income Countries: Bayesian Network Meta-analyses of Randomized Clinical Trials – JAMA Network Open (free)

 

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Comparison of the Harms, Advantages, and Costs Associated With Alternative Guidelines for the Evaluation of Hematuria – JAMA Internal Medicine (free for a limited period)

Commentaries: Hematuria Practice Guidelines That Explicitly Consider Harms and Costs – JAMA Internal Medicine (free for a limited period) AND Evaluating Hematuria: Uniform Use of CT Seen as Risky and Expensive – NEJM Journal Watch (free)

 

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Alex Nowbar’s journal reviews, 25 July 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis – The BMJ (free)

Commentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)

“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”

 

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Diagnosing the Onset of Menopause

23 Jul, 2019 | 01:47h | UTC

Diagnosing the Onset of Menopause – JAMA (free for a limited period)

Clinical Review Audio: Diagnosing Menopause (free)

 


Alex Nowbar’s journal reviews, 18 July 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing – Korean Journal of Family Medicine (free PDF)

“individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.”

 


Clinical Practice: Measles

14 Jul, 2019 | 20:05h | UTC

Urinary Tract Infections Affect Millions. The Cures Are Faltering. – The New York Times (10 articles per month are free)

“As the infections become increasingly resistant to antibiotics, some standard treatments no longer work for an ailment that was once easily cured.”

 


Preclinical Alzheimer Disease—Early Diagnosis or Overdiagnosis? – JAMA Internal Medicine (free for a limited period)

 

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Ann Robinson’s journal review, 10 July 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Review: Subclinical Hypothyroidism

10 Jul, 2019 | 02:36h | UTC

Subclinical Hypothyroidism – A Review – JAMA (free link for a limited period)

Related: BMJ Guideline: Treatment of Subclinical Hypothyroidism (free guideline and commentaries)

 


Use of Directly Observed Therapy to Assess Treatment Adherence in Patients With Apparent Treatment-Resistant Hypertension – JAMA Internal Medicine (free link for a limited period)

Commentaries: Directly Observed Therapy Effective for Treatment-Resistant Hypertension – Clinical Advisor (free) AND Think it’s treatment-resistant hypertension? Your eyes need to DOT (directly observe therapy) – Univadis (free registration required)

 

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GINA 2019: a fundamental change in asthma management – European Respiratory Journal (free)

Original Guideline: 2019 GINA Report, Global Strategy for Asthma Management and Prevention (free PDF)

Related Studies: #ATS2019 – Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma (link to abstract and commentaries) AND Randomized Controlled Trials: Treatments for Mild Asthma Compared (link to abstract and commentaries)

“GINA no longer recommends treating adults/adolescents with asthma with short-acting bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a daily corticosteroid-containing inhaler, to reduce risk of severe exacerbations.”

 


Ann Robinson’s journal review, 3 July 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Clinical Update: Syphilis

30 Jun, 2019 | 17:53h | UTC

Choosing Wisely: Case Studies from the Top 10 Recommendations Across Campaigns – The Commonwealth Fund (free case studies)

See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada

 

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Alex Nowbar’s journal reviews, 25 June 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Alex Nowbar’s journal reviews, 20 May 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis – JAMA Cardiology (free for a limited period)

Commentaries: The Demise of Vitamin D for Cardiovascular Prevention – JAMA Cardiology (free for a limited period) AND Does Vitamin D Supplementation Provide Cardiovascular Protection? – MPR (free)

 

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Safety and efficacy of aspirin for primary prevention of cancer: a meta-analysis of randomized controlled trials – Journal of Cancer Research and Clinical Oncology (free)

“Our study did not find any significant reductions in cancer-related mortality or cancer incidence when compared aspirin use with placebo or no aspirin.”

 


Top 10 Medical Myths, Busted

11 Jun, 2019 | 03:31h | UTC

Top 10 medical myths, busted – ACP Internist (free)

“Ten medical myths persist despite all the evidence.”

 


Ann Robinson’s journal review, 5 June 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Prevalence and Cost of Care Cascades After Low-Value Preoperative Electrocardiogram for Cataract Surgery in Fee-for-Service Medicare Beneficiaries – JAMA Internal Medicine (free for a limited period)

Commentary: Cascades Of Care – American Council on Science and Health (free)

Related: Evaluation of an Intervention to Reduce Low-Value Preoperative Care for Patients Undergoing Cataract Surgery (link to abstract and commentary) AND Systematic Review: Routine Preoperative Medical Testing for Cataract Surgery (free)

 

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Association of Preterm Birth With Risk of Ischemic Heart Disease in Adulthood – JAMA Pediatrics (free for a limited period)

Editorial: Cardiovascular Risk in Adults Born Preterm: Time to Act (free for a limited period)

Commentary: Preemies and early arrivals have higher risk of heart disease as adults – Reuters (free)

 

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Review: Menopausal Hormone Therapy

31 May, 2019 | 06:30h | UTC

Menopausal Hormone Therapy – JAMA (free for a limited period)

Podcast: Menopausal Hormone Therapy (free audio)

 


Tramadol for osteoarthritis – Cochrane Library (free)

Summary: Tramadol for osteoarthritis – Cochrane Library (free)

“tramadol alone or in combination with acetaminophen probably has no important benefit on mean pain or function in people with osteoarthritis, although slightly more people in the tramadol group report an important improvement”

 


Alex Nowbar’s journal reviews, 29 May 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.