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Evidence-based Medicine

New guidelines to improve reporting standards of studies that investigate causal mechanisms.

28 Sep, 2021 | 09:00h | UTC

News release: New guidelines to improve reporting standards of studies that investigate causal mechanisms – University of Oxford

Original article: A Guideline for Reporting Mediation Analyses of Randomized Trials and Observational Studies: The AGReMA Statement – JAMA (free for a limited period)

Commentary: Reporting Findings From Mediation Analyses – JAMA (free for a limited period)

 

Commentary on Twitter (thread – click for more)

 

Opinion | Inappropriate Mixing Clinical and Systemic Thinking: Vaccines in the Young.

26 Sep, 2021 | 22:07h | UTC

Inappropriate Mixing Clinical and Systemic Thinking: Vaccines in the Young – Medium

 

Fraudulent ivermectin studies open up new battleground between science and misinformation.

26 Sep, 2021 | 22:08h | UTC

Fraudulent ivermectin studies open up new battleground between science and misinformation – The Guardian

 

Video: Understanding noninferiority trials: purpose, power, and pitfalls.

26 Sep, 2021 | 21:39h | UTC

On Record: Understanding Noninferiority Trials: Purpose, Power, and Pitfalls – TCTMD

 

Expert panel recommends against use of race in assessment of kidney function.

24 Sep, 2021 | 09:01h | UTC

Expert panel recommends against use of race in assessment of kidney function – STAT

Original Guidance: A Unifying Approach for GFR Estimation: Recommendations of the NKF-ASN Task Force on Reassessing the Inclusion of Race in Diagnosing Kidney Disease – American Journal of Kidney Diseases

 

Commentary on Twitter

 

Landmark articles suggest eliminating race in the estimation of kidney function.

24 Sep, 2021 | 09:03h | UTC

Editorial: Time to Eliminate Health Care Disparities in the Estimation of Kidney Function – New England Journal of Medicine

Study 1: New Creatinine- and Cystatin C–Based Equations to Estimate GFR without Race – New England Journal of Medicine

Study 2: Race, Genetic Ancestry, and Estimating Kidney Function in CKD – New England Journal of Medicine

Commentaries:

NIH-supported study suggests alternative to race-based kidney function calculations – NIH News Releases

Remove Race From Equation Used to Assess Kidney Function, Researchers Say – AJMC

Researchers identify potential approach to eliminate race from equations to estimate kidney function – News Medical

 

Commentary on Twitter

 

Cochrane Special Collection | De-implementation of low-value health care: resource prioritization in the COVID-19 pandemic era.

23 Sep, 2021 | 10:13h | UTC

De-implementation of low-value health care: resource prioritization in the COVID-19 pandemic era – Cochrane Library

Editorial: Making wise choices about low‐value health care in the COVID‐19 pandemic – Cochrane Library

Commentary: Choosing health care wisely when resources are scarce – Evidently Cochrane

 

Commentaries on Twitter

 

The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.

23 Sep, 2021 | 10:08h | UTC

The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable – Nature Medicine

 

Commentary on Twitter

 

Effectiveness and Ethics of Incentives for Research Participation: 2 Randomized Clinical Trials.

21 Sep, 2021 | 08:57h | UTC

Effectiveness and Ethics of Incentives for Research Participation: 2 Randomized Clinical Trials – JAMA Internal Medicine (free for a limited period)

Editorial: Evidence for the Ethics of Incentivizing Clinical Trial Enrollment? – JAMA Internal Medicine

 

Commentary on Twitter

 

Editorial: Authorship and Publication Matters: Credit and Credibility.

21 Sep, 2021 | 08:54h | UTC

Authorship and Publication Matters: Credit and Credibility – Anesthesiology

Related: When is ‘self-plagiarism’ OK? New guidelines offer researchers rules for recycling text – Science

 

Commentary on Twitter

 

Side effect patterns in a crossover trial of statin, placebo, and no treatment – This N-of-1 trial, now published in full, suggests the nocebo effect causes most of statins muscle adverse effects.

19 Sep, 2021 | 23:30h | UTC

Side Effect Patterns in a Crossover Trial of Statin, Placebo, and No Treatment – Journal of the American College of Cardiology

See also: #AHA20 – In patients who had discontinued statins because of side effects, a N-of-1 trial of a statin, placebo, or no treatment found that side effects often attributed to statins were the same for those taking a placebo

 

Editorial: Striving for diversity in research studies.

16 Sep, 2021 | 10:02h | UTC

Striving for Diversity in Research Studies – New England Journal of Medicine

 

How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines.

16 Sep, 2021 | 09:56h | UTC

How to write a guideline: a proposal for a manuscript template that supports the creation of trustworthy guidelines – Blood Advances

 

Ivermectin: Cochrane’s most talked about review so far, ever. Why?

15 Sep, 2021 | 09:07h | UTC

Ivermectin: Cochrane’s most talked about review so far, ever. Why? – Cochrane Library

Original review: Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.

 

Commentary on Twitter

 

Opinion | Don’t make early career researchers ‘ghost authors.’ Give us the credit we deserve.

14 Sep, 2021 | 08:50h | UTC

Don’t make early career researchers ‘ghost authors.’ Give us the credit we deserve – Science

 

Face masks for COVID pass their largest test yet – “A rigorous study finds that surgical masks are highly protective, but cloth masks fall short”.

10 Sep, 2021 | 05:36h | UTC

Face masks for COVID pass their largest test yet – Nature

Original study: [Preprint] Largest study of masks yet details their importance in fighting Covid-19.

 

Commentary on Twitter

 

Perspective | Rethinking medication adherence.

9 Sep, 2021 | 08:55h | UTC

Rethinking Medication Adherence – Therapeutics Initiative

 

Opinion | Video: Immunity is the only way through a pandemic (w/Dr. Monica Gandhi).

7 Sep, 2021 | 10:45h | UTC

Immunity Is The Only Way Through A Pandemic (w/Dr. Monica Gandhi) – ZDoggMD

 

Opinion | “The downsides of masking young students are real”.

3 Sep, 2021 | 10:24h | UTC

The Downsides of Masking Young Students Are Real – The Atlantic

 

Commentary with a rebuttal on Twitter (thread – click for more)

 

Drowning in the literature? These smart software tools can help.

3 Sep, 2021 | 10:09h | UTC

Drowning in the literature? These smart software tools can help – Nature

 

EBM Learning | How to create PICO questions about diagnostic test. In this paper, the author presents an example of a PICO for a question about test accuracy and an example of a PICO for a question about the effects of care with a test.

2 Sep, 2021 | 08:18h | UTC

How to create PICO questions about diagnostic test – BMJ Evidence-Based Medicine

 

Opinion | COVID vaccines: we need to find out which incentives actually work – the author argues that policies to promote vaccine uptake should be tested in randomized clinical trials.

31 Aug, 2021 | 08:56h | UTC

COVID vaccines: we need to find out which incentives actually work – The Conversation

 

Guide to Statistics and Methods: Interpreting the ACC/AHA clinical practice guideline recommendation classification system.

25 Aug, 2021 | 08:46h | UTC

Interpreting the ACC/AHA Clinical Practice Guideline Recommendation Classification System – JAMA (free for a limited period)

 

Digital transformation of major scientific meetings induced by the COVID-19 pandemic: insights from the ESC 2020 annual congress.

25 Aug, 2021 | 08:35h | UTC

Digital transformation of major scientific meetings induced by the COVID-19 pandemic: insights from the ESC 2020 annual congress – European Heart Journal Digital Health

 

Commentary on Twitter

 

Opinion | The FDA really did have to take this long – “If vaccine approval feels maddeningly scrupulous, that’s because the alternative is worse”.

24 Aug, 2021 | 10:01h | UTC

The FDA Really Did Have to Take This Long – The Atlantic

 

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