EBM & Clinical Trials

Childhood Obesity Is a Major Problem. Research Isn’t Helping. – The New York Times (10 articles per month are free)

“Something is missing with many study methods.”

 


Alex Nowbar’s weekly research review, 17 January 2020 – BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


FDA and NIH let clinical trial sponsors keep results secret and break the law – Science (a few articles per month are free)

 

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‘Evidence-Based Medicine’ and the Expulsion of Peter Gøtzsche – Undark (free)

 

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The Altmetric TOP 100 Articles of 2019

5 Jan, 2020 | 14:24h | UTC

The Altmetric TOP 100 Articles of 2019

See the 54 articles in the List Related to Medical and Health Sciences

“In the past 12 months, Altmetric has tracked over 62.5 million mentions of 2.7 million research outputs. Here, we’ve highlighted the 100 most-discussed works of 2019 – those that have truly captured the public imagination.”

 

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Working 9 to 5, not the way to make an academic living: observational analysis of manuscript and peer review submissions over time – The BMJ (free)

Commentaries: Study busts 9 to 5 model for academic work – Queensland University of Technology (free) AND There’s No Winter Break From ‘Publish or Perish’ – The New York Times (a few articles per month are free)

 

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Predatory journals: no definition, no defence – Nature (free)

Related: Many Academics Eager to Publish in Worthless Journals – The New York Times (10 articles per month are free) AND Predatory Journals Are Such a Big Problem It’s Not Even Funny – HIV and ID Observations (free)

“Leading scholars and publishers from ten countries have agreed a definition of predatory publishing that can protect scholarship. It took 12 hours of discussion, 18 questions and 3 rounds to reach.”

 

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Surgeons withdraw support for heart disease advice – BBC (free)

YouTube Video: European guidelines on heart disease under review – BBC Newsnight (free)

See also: EACTS responds to BBC Newsnight’s investigation on the EXCEL trial – European Association for Cardio-Thoracic Surgery (free)

Commentary: EACTS Pulls Out of Left Main Guidelines After BBC Bombshell Alleging EXCEL Trial Cover-up – TCTMD (free)

 

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Cochrane Sustainable Healthcare: evidence for action on too much medicine – Cochrane Library (free)

News Release: Launch of new Cochrane Sustainable Healthcare Field – Cochrane Library (free)

See Website: Cochrane Sustainable Healthcare (free)

 

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Ann Robinson’s research reviews, 5 December 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals

 


Pathways to independence: towards producing and using trustworthy evidence – The BMJ (free)

See Complete Series: Commercial Influence in Health: from Transparency to Independence (free articles)

Commentary: Time to end drug company distortion of medical evidence – The Conversation (free)

 

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Alex Nowbar’s weekly review, 15 November 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Ann Robinson’s journal review, 7 November 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Association between gifts from pharmaceutical companies to French general practitioners and their drug prescribing patterns in 2016: retrospective study using the French Transparency in Healthcare and National Health Data System databases – The BMJ (free)

 

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Reporting research findings to participants is an ethical imperative – The BMJ (free for a limited period)

 

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Alex Nowbar’s weekly review, 1 November 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Sepsis hysteria: excess hype and unrealistic expectations – The Lancet (free)

Commentary: Sepsis myths create ‘unhealthy climate of fear’, say experts – The Guardian (free)

Source: Grupo UTIclínica – HCFMUSP

 

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Older Patients (Still) Left Out of Cancer Clinical Trials – JAMA (free for a limited period)

Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)

 

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Ann Robinson’s journal review, 23 October 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Neglecting Major Health Problems and Broadcasting Minor, Uncertain Issues in Lifestyle Science – JAMA (free for a limited period)

 

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Alex Nowbar’s weekly review—17 October 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


The Future of OA: A large-scale Analysis Projecting Open Access Publication and Readership – bioRxiv (free PDF)

News Release: The Future of OA: A large-scale analysis projecting Open Access publication and readership – Our Research Blog (free)

 

“In 2019:

31% of all journal articles are available as OA

52% of all article views are to OA articles

 

Given existing trends, we estimate that by 2025:

44% of all journal articles will be available as OA

70% of all article views will be to OA articles”

 

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A Guide to Prospective Meta-analysis

10 Oct, 2019 | 09:28h | UTC

A guide to prospective meta-analysis – The BMJ (free for a limited period)

 


Alex Nowbar’s journal reviews—8 October 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


The Folly of Big Science Awards – The New York Times (10 articles per month are free)

 


Should antidepressants be used for major depressive disorder? – BMJ Evidence-Based Medicine (free)

Related Meta-analysis: Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis – The Lancet (free)

Related Commentary: Do Antidepressants Work? – The New York Times (10 articles per month are free)

“Generally, all the previous reviews show that antidepressants seem to have statistically significant effects on depressive symptoms, but the size of the effect has questionable importance to most patients.”

 


Alex Nowbar’s journal review, 24 September 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Alex Nowbar’s journal review, 18 September 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Ann Robinson’s journal review, 10 September 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


2019 Update on Medical Overuse

10 Sep, 2019 | 01:50h | UTC

Ann Robinson’s journal review, 5 September 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Key Concepts for Making Informed Choices

15 Aug, 2019 | 07:47h | UTC

Improving the Quality of Dietary Research – JAMA (free for a limited period)

Related JAMA Viewpoints: The Challenge of Reforming Nutritional Epidemiologic Research (free for a limited period) AND Current and Future Landscape of Nutritional Epidemiologic Research (free for a limited period)

 


Alex Nowbar’s journal review, 5 August 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Harms from Uninformative Clinical Trials – JAMA (free)

“An uninformative trial is one that provides results that are not of meaningful use for a patient, clinician, researcher, or policy maker.”

 


How a data detective exposed suspicious medical trials – Nature (free)

Related: Dozens of recent clinical trials may contain wrong or falsified data (free study by John Carlisle)

“Anaesthetist John Carlisle has spotted problems in hundreds of research papers — and spurred a leading medical journal to change its practice.”

 


Alex Nowbar’s journal reviews, 18 July 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Ann Robinson’s journal review, 10 July 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Ann Robinson’s journal review, 3 July 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Alex Nowbar’s journal reviews, 25 June 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Alex Nowbar’s journal reviews, 20 May 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


To Save The Science Poster, Researchers Want To Kill It And Start Over – NPR (free)

Related Video: How to create a better research poster in less time (including templates) (free)

 

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Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals – eLife (free)

Commentaries: Almost 400 medical practices found ineffective in analysis of 3,000 studies – eLIFE (free) AND Hundreds of current medical practices may be ineffective – Medical News Today (free)

 

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Perspective: The War to Free Science

11 Jun, 2019 | 03:11h | UTC

The war to free science – Vox (free)

Related: Plan S: Making Full and Immediate Open Access a Reality (free) AND Open Access 2018: A Year of Funders and Universities Drawing Lines in the Sand (free)

“How librarians, pirates, and funders are liberating the world’s academic research from paywalls.”

 


New preprint server for medical research – The BMJ (free)

See also: New preprint server for the health sciences announced today – Cold Spring Harbor Laboratory (CSHL) (free) AND How to bring preprints to the charged field of medicine – Nature News (free)

 

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Ann Robinson’s journal review, 5 June 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Rethinking impact factors: better ways to judge a journal – Nature (free)

“We need a broader, more-transparent suite of metrics to improve science publishing, say Paul Wouters, colleagues and co-signatories.”

 


Alex Nowbar’s journal reviews, 29 May 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Alex Nowbar’s journal reviews, 14 May 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Why most diagnostic procedures aren’t beneficial – PulmCrit (free)

“when strict evidence-based medicine is applied to procedures, they are often less impressive”.

 


Proposal: Reforming disease definitions: a new primary care led, people-centred approach – BMJ Evidence Based Medicine (free)

Commentary: We need new rules for defining who is sick. Step 1: remove vested interests – The Conversation (free)

 

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Ann Robinson’s research reviews, 9 April 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Ann Robinson’s weekly research reviews, 2 April 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Alex Nowbar’s research reviews, 26 March 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Why you should be a “medical conservative” – Lown Institute (free)

Original Article: Perspective: The Case for Being a Medical Conservative (free article and twitter thread)

“being a medical conservative means being skeptical about new medical advances until unbiased and high-quality evidence shows a clear benefit”

 


Clinical practice guidelines and the overuse of health care services: need for reform – Canadian Medical Association Journal (free for a limited period)

 

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The Case for Being a Medical Conservative – The American Journal of Medicine (free for a limited period)

 

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Overview of Cost-effectiveness Analysis – JAMA (free for a limited period)

 


Christopher Martyn’s research reviews, 11 March 2019 – The BMJ Opinion (free)

Christopher Martyn reviews the latest research from the top medical journals.

 


Guide to Statistics and Methods: Treatment Effects in Multicenter Randomized Clinical Trials – JAMA (free for a limited period)

 


Ann Robinson’s research reviews, 5 March 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Five Warning Signs of Overdiagnosis

11 Feb, 2019 | 00:05h | UTC

Alex Nowbar’s research reviews, 5 February 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Research Methods & Reporting: A guide to systematic review and meta-analysis of prognostic factor studies – The BMJ (free for a limited period)

 


Ann Robinson’s research reviews, 29 January 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Mediation Analysis – JAMA (free for a limited period)

 


Alex Nowbar’s weekly research reviews, 22 January 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Zackary Berger’s weekly research reviews, 14 January 2019 – The BMJ (free)

“Zackary Berger reviews the latest research from the top medical journals”.

 


American College of Physicians Ethics Manual: Seventh Edition – Annals of Internal Medicine (free)

News Release: American College of Physicians releases new edition of Ethics Manual (free)

“Genetic testing, telemedicine, end-of-life care, and human subjects research are among issues examined in new edition of ACP Ethics Manual” (from News Release)

 


A systematic review of trial-level meta-analyses measuring the strength of association between surrogate end-points and overall survival in oncology – European Journal of Cancer (free for a limited period)

“we found most surrogates in oncology had low or modest correlation with OS, which suggests that caution should be used when making conclusions based on surrogate markers.”

 


Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial – The BMJ (free)

Linked Opinion: We jumped from planes without parachutes (and lived to tell the tale) – The BMJ Opinion (free)

Commentaries: Researchers Show Parachutes Don’t Work, But There’s A Catch – NPR (free) AND Evidence-Based Satire – The Health Care Blog (free)

 

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Ann Robinson’s research reviews, 7 January 2019 – The BMJ (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Guide to Statistics and Methods: Random-Effects Meta-analysis: Summarizing Evidence With Caveats – JAMA (free for a limited period)