EBM & Clinical Trials

Key Concepts for Making Informed Choices

15 Aug, 2019 | 07:47h | UTC

Improving the Quality of Dietary Research – JAMA (free for a limited period)

Related JAMA Viewpoints: The Challenge of Reforming Nutritional Epidemiologic Research (free for a limited period) AND Current and Future Landscape of Nutritional Epidemiologic Research (free for a limited period)

 


Alex Nowbar’s journal review, 5 August 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Harms from Uninformative Clinical Trials – JAMA (free)

“An uninformative trial is one that provides results that are not of meaningful use for a patient, clinician, researcher, or policy maker.”

 


How a data detective exposed suspicious medical trials – Nature (free)

Related: Dozens of recent clinical trials may contain wrong or falsified data (free study by John Carlisle)

“Anaesthetist John Carlisle has spotted problems in hundreds of research papers — and spurred a leading medical journal to change its practice.”

 


Alex Nowbar’s journal reviews, 18 July 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Ann Robinson’s journal review, 10 July 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Ann Robinson’s journal review, 3 July 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Alex Nowbar’s journal reviews, 25 June 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Alex Nowbar’s journal reviews, 20 May 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


To Save The Science Poster, Researchers Want To Kill It And Start Over – NPR (free)

Related Video: How to create a better research poster in less time (including templates) (free)

 

Related Commentary on Twitter

 


Meta-Research: A comprehensive review of randomized clinical trials in three medical journals reveals 396 medical reversals – eLife (free)

Commentaries: Almost 400 medical practices found ineffective in analysis of 3,000 studies – eLIFE (free) AND Hundreds of current medical practices may be ineffective – Medical News Today (free)

 

Related Commentary on Twitter

 


Perspective: The War to Free Science

11 Jun, 2019 | 03:11h | UTC

The war to free science – Vox (free)

Related: Plan S: Making Full and Immediate Open Access a Reality (free) AND Open Access 2018: A Year of Funders and Universities Drawing Lines in the Sand (free)

“How librarians, pirates, and funders are liberating the world’s academic research from paywalls.”

 


New preprint server for medical research – The BMJ (free)

See also: New preprint server for the health sciences announced today – Cold Spring Harbor Laboratory (CSHL) (free) AND How to bring preprints to the charged field of medicine – Nature News (free)

 

Related Commentary on Twitter

 


Ann Robinson’s journal review, 5 June 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Rethinking impact factors: better ways to judge a journal – Nature (free)

“We need a broader, more-transparent suite of metrics to improve science publishing, say Paul Wouters, colleagues and co-signatories.”

 


Alex Nowbar’s journal reviews, 29 May 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Alex Nowbar’s journal reviews, 14 May 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Why most diagnostic procedures aren’t beneficial – PulmCrit (free)

“when strict evidence-based medicine is applied to procedures, they are often less impressive”.

 


Proposal: Reforming disease definitions: a new primary care led, people-centred approach – BMJ Evidence Based Medicine (free)

Commentary: We need new rules for defining who is sick. Step 1: remove vested interests – The Conversation (free)

 

Related Commentary on Twitter

 


Ann Robinson’s research reviews, 9 April 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Ann Robinson’s weekly research reviews, 2 April 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Alex Nowbar’s research reviews, 26 March 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Why you should be a “medical conservative” – Lown Institute (free)

Original Article: Perspective: The Case for Being a Medical Conservative (free article and twitter thread)

“being a medical conservative means being skeptical about new medical advances until unbiased and high-quality evidence shows a clear benefit”

 


Clinical practice guidelines and the overuse of health care services: need for reform – Canadian Medical Association Journal (free for a limited period)

 

Related Commentary on Twitter

 


The Case for Being a Medical Conservative – The American Journal of Medicine (free for a limited period)

 

Related Commentary on Twitter (thread, click for more)

 

 


Overview of Cost-effectiveness Analysis – JAMA (free for a limited period)

 


Christopher Martyn’s research reviews, 11 March 2019 – The BMJ Opinion (free)

Christopher Martyn reviews the latest research from the top medical journals.

 


Guide to Statistics and Methods: Treatment Effects in Multicenter Randomized Clinical Trials – JAMA (free for a limited period)

 


Ann Robinson’s research reviews, 5 March 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Five Warning Signs of Overdiagnosis

11 Feb, 2019 | 00:05h | UTC

Alex Nowbar’s research reviews, 5 February 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Research Methods & Reporting: A guide to systematic review and meta-analysis of prognostic factor studies – The BMJ (free for a limited period)

 


Ann Robinson’s research reviews, 29 January 2019 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Mediation Analysis – JAMA (free for a limited period)

 


Alex Nowbar’s weekly research reviews, 22 January 2019 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Zackary Berger’s weekly research reviews, 14 January 2019 – The BMJ (free)

“Zackary Berger reviews the latest research from the top medical journals”.

 


American College of Physicians Ethics Manual: Seventh Edition – Annals of Internal Medicine (free)

News Release: American College of Physicians releases new edition of Ethics Manual (free)

“Genetic testing, telemedicine, end-of-life care, and human subjects research are among issues examined in new edition of ACP Ethics Manual” (from News Release)

 


A systematic review of trial-level meta-analyses measuring the strength of association between surrogate end-points and overall survival in oncology – European Journal of Cancer (free for a limited period)

“we found most surrogates in oncology had low or modest correlation with OS, which suggests that caution should be used when making conclusions based on surrogate markers.”

 


Parachute use to prevent death and major trauma when jumping from aircraft: randomized controlled trial – The BMJ (free)

Linked Opinion: We jumped from planes without parachutes (and lived to tell the tale) – The BMJ Opinion (free)

Commentaries: Researchers Show Parachutes Don’t Work, But There’s A Catch – NPR (free) AND Evidence-Based Satire – The Health Care Blog (free)

 

Related Commentary on Twitter

 


Ann Robinson’s research reviews, 7 January 2019 – The BMJ (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Guide to Statistics and Methods: Random-Effects Meta-analysis: Summarizing Evidence With Caveats – JAMA (free for a limited period)

 


Congratulations on the Promotion. But Did Science Get a Demotion? – The New York Times (10 articles per month are free)

“The incentives of grant funding and career advancement, even the potential for fame, can influence researchers”

 


The 2018 Altmetric Top 100 Articles

14 Dec, 2018 | 00:04h | UTC

The 2018 Altmetric Top 100 Articles (free)

“In the past year, Altmetric has tracked over 25 million mentions of 2.8 million research outputs. This page highlights the top 100 most-mentioned scholarly articles published in the past year – those which have truly captured the public imagination.”

 


Focus on randomised clinical trials – Intensive Care Medicine (free PDF) (via @CritCareReviews)

Related: What should we stop doing in the ICU? – ICU Management & Practice (free)

“Their results add to what appears to be a constant theme in critical care, ‘less is more’ based on RCT results”

 


Alex Nowbar’s weekly research reviews, 3 December 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications: A Systematic Review – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Some research may be encouraging ineffective prescriptions, says new study – McGill University (free)

“Our point is not to condemn these individual trials. Instead, we are saying that—when you zoom out and look at what’s happening at the level of the forest—the trees begin to look less healthy.” (from McGill University)

 


Ann Robinson’s research reviews, 26 November 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Alex Nowbar’s research reviews, 12 November 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Ann Robinson’s weekly research reviews, 5 November 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Alex Nowbar’s research reviews, 29 October 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Alex Nowbar’s research reviews—22 October 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Antidepressant withdrawal: reviewing the paper behind the headlines – The Mental Elf (free) (via @AllenFrancesMD)

Original Systematic Review: Antidepressant Withdrawal Effects (free article and commentaries)

“Last week a new review said: – Over half of people taking antidepressants experience withdrawal symptoms – These symptoms are severe in over half of cases. The press had a field day! Our blog today by @J_F_Hayes and @sameerjauhar offers a different view” (via @Mental_Elf see Tweet)

 


Many Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results – Advances in Methods and Practices in Psychological Science (free) (via @f_g_zampieri)

“This is one of most important studies published this century. 29 teams used same data set to address same research question; estimated effect sizes ranged from 0.89 to 2.93 in odds-ratio units. Dramatic implications for observational research.” (via @hmkyale see Tweet)

 


Ann Robinson’s research reviews, 15 October 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Professional Societies Should Abstain From Authorship of Guidelines and Disease Definition Statements – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Professional Societies, Clinical Specialists, and Guidelines – Circulation: Cardiovascular Quality and Outcomes (free) AND Turn Cardiology Guidelines Over to Outsiders – MedPage Today (free registration required)

John Ioannidis, MD. “questioned whether cardiovascular guidelines “homogenize biased, collective, and organized ignorance” through use of predominantly “insider” experts as authors.” (from MedPage Today)

 


How to Write a Thorough Peer Review

16 Oct, 2018 | 21:32h | UTC

Zackary Berger’s journal reviews, 8 October 2018 – The BMJ Opinion (free)

Zackary Berger reviews the latest research from the top medical journals.

 


Perspective: What the Tests Don’t Show

11 Oct, 2018 | 20:11h | UTC

What the tests don’t show – The Washington Post (a few articles per month are free)

“Many doctors are surprisingly bad at reading test results and/or fail to grasp how false positives work. This is putting patients at risk” (via @pash22 see Tweet)

 


When Conventional Wisdom Is Put on Trial – UNDark (free) (via @EricTopol)

“The author of “Randomistas” shows how randomized trials have overturned many popular findings, from hormone therapy to the benefits of multivitamins.”

 


No more first authors, no more last authors – Nature (free)

“The controversial suggestion that we “blow up” authorship conventions to foster team, collaborative science” (via @EricTopol see Tweet)

 


Ann Robinson’s research reviews, 24 September 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Congratulations. Your Study Went Nowhere

27 Sep, 2018 | 22:42h | UTC

Congratulations. Your Study Went Nowhere – The New York Times (10 articles per month are free) (via @kennylinafp)

“Researchers should embrace negative results instead of accentuating the positive, which is one of several biases that can lead to bad science.”

 


Zackary Berger’s journal reviews, 17 September 2018 – The BMJ Opinion (free)

Zackary Berger reviews the latest research from the top medical journals.

 


Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free)

“All screening programs do harm, some do good as well.”

 


2018 Global State of Peer Review

14 Sep, 2018 | 01:30h | UTC

Guide to Statistics and Methods: Case-Control Studies: Using “Real-world” Evidence to Assess Association – JAMA (free for a limited period)

 


Opinion: Publish Peer Reviews

31 Aug, 2018 | 01:47h | UTC

Publish peer reviews – Nature News (free)

“Jessica K. Polka and colleagues call on journals to sign a pledge to make reviewers’ anonymous comments part of the official scientific record.”

 


The Challenge of Reforming Nutritional Epidemiologic Research – JAMA (free for a limited period)

“…the emerging picture of nutritional epidemiology is difficult to reconcile with good scientific principles. The field needs radical reform.”

 


How Unpaywall is transforming open science – Nature News (free)

Related: Unlocking paywalled research papers (legally) (free commentaries) AND Half of papers searched for online are free to read (free)

We have been using the Unpaywall Extension for a while, and it is indeed a handy tool to find free versions (entirely legal) of paywalled articles.

 


Review: Overdiagnosis in Primary Care

17 Aug, 2018 | 02:10h | UTC