Better Medicine – Shared decisions, best evidence

23Jun
2017

Better Medicine – Shared decisions, best evidence

Related article: Overdiagnosis and overtreatment: generalists — it’s time for a grassroots revolution (free)

“This Better Medicine resource page builds on the work of The BMJ’s Too Much Medicine initiative and the overdiagnosis group of the RCGP in helping health professionals worldwide to share knowledge with patients and jointly make better informed choices about their care.

 

Why We Overrate the Lifesaving Power of Cancer Tests

23Jun
2017

Conflicts of interest in healthcare, academics, public relations and journalism

21Jun
2017

Richard Lehman’s weekly review of medical journals

20Jun
2017

Eight Tips for using Twitter during health-related conferences

19Jun
2017

New science data-sharing rules are two scoops of disappointment

19Jun
2017

Challenges in Opening and Enrolling Patients in Clinical Trials

16Jun
2017

Anecdotes are unreliable evidence

16Jun
2017

Treatments can harm

16Jun
2017

Machine Learning Versus Standard Techniques for Updating Searches for Systematic Reviews

16Jun
2017

Machine Learning Versus Standard Techniques for Updating Searches for Systematic Reviews: A Diagnostic Accuracy Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentary: Artificial intelligence may help doctors keep up with new research – Reuters (free)

“Machine-learning fed by citations of a systematic saved a ton of time for updating it, didn’t miss important studies” (RT @hildabast see Tweet)

 

Number needed to treat (NNT) in clinical literature

13Jun
2017

A real-world approach to Evidence-Based Medicine in general practice

13Jun
2017

Dozens of recent clinical trials may contain wrong or falsified data

7Jun
2017

Data Sharing Statements for Clinical Trials

7Jun
2017

Multiple outcomes and analyses in clinical trials create challenges for interpretation and research synthesis

7Jun
2017

Multiple outcomes and analyses in clinical trials create challenges for interpretation and research synthesis – Journal of Clinical Epidemiology (free)

“RCTs included hundreds of outcomes and results; a small proportion were in public reports. Trialists and meta-analysts may cherry-pick what they report from multiple sources of RCT information.” (RT @hildabast see Tweet)

 

A manifesto for reproducible Science

4Jun
2017

Health Policy Trials

2Jun
2017

Research transparency: 5 questions about open science answered

2Jun
2017

Science Needs a Solution for the Temptation of Positive Results

30May
2017

Diagnosis creep: the new problem in medicine

30May
2017

What is a Systematic Review?

30May
2017

Updated tutorial: What is a Systematic Review? – PubMed Health (free) (RT @hildabast)

 

Joint statement on public disclosure of results from clinical trials – World Health Organization

19May
2017

Joint statement on public disclosure of results from clinical trials – World Health Organization (free)

News release: Major research funders and international NGOs to implement WHO standards on reporting clinical trial results (free)

Commentary: Industry leaders agree to implement UN agency’s standards on clinical trial reporting – United Nations News Centre (free)

“Funders of medical research & international NGOs to implement WHO standards on reporting clinical trial results”. “Today, on average 50% of Clinical Trials go unreported, according to several studies, often because the results are negative”. “Unreported trial results leave an incomplete & potentially misleading picture of the risks & benefits of vaccines, drugs and medical devices” (see Tweets)

 

How to rein in the widening disease definitions that label more healthy people as sick

17May
2017

Countering cognitive biases in minimizing low value care

12May
2017

Review: Countering cognitive biases in minimizing low value care – The Medical Journal of Australia (free)

“How cognitive bias affects clinical decision making and what to do about it. Well written & useful” (RT @carissa_bon and @JulieLeask see Tweet)

 

Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today

6May
2017

Research letter: Applicability of the IMPROVE-IT Trial to Current Patients With Acute Coronary Syndrome – JAMA Internal Medicine (link to abstract – $ for full text)

Source: Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today (free registration required)

Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)

Patients in clinical trials are often younger, healthier (with less comorbidities), better plugged in to the health care system, better educated and wealthier, indicating that the external validity or generalizability of much of the current evidence to real-world settings may be relatively weak.

 

As scientists take to Twitter, study shows power of ‘visual abstract’ graphics

4May
2017

Statistical significance vs. clinical significance

24Apr
2017

Too many studies have hidden conflicts of interest. A new tool makes it easier to see them

21Apr
2017

Too many studies have hidden conflicts of interest. A new tool makes it easier to see them – VOX (free)

“Great news: PubMed is finally publishing info about funding sources/conflicts of interest on its abstracts” (RT @paimadhu and @juliaoftorontosee Tweet)

 

Initiative aims to break science’s citation paywall

7Apr
2017

Unlocking paywalled research papers (legally)

6Apr
2017

Unpaywall finds free versions of paywalled papers – Nature (free) (RT @dannykay68)

See also: Unlocking paywalled research papers: Two big steps forward, two steps back, by James C Coyne – Coyne of the Realm (RT @hildabast)

Apparently, it successfully finds an open-access version (completely legal) of a paper around 30% of the time. We have tried and it worked for some of the articles we’ve tested. See it for yourself.

 

To Screen or not to Screen?

4Apr
2017

Science papers are getting harder to read

4Apr
2017

The seven deadly sins of statistical misinterpretation

31Mar
2017

Exposing peer review

30Mar
2017

Ten Steps to Producing a Well-Written Evidence-Based Health Care Dissertation

30Mar
2017

Regression to the mean, and its importance in healthcare decisions

29Mar
2017

Regression to the mean, or why perfection rarely lasts – The Conversation (free) (RT @PaulGlasziou)

“Regression to the mean, and its importance in healthcare decisions” (RT @Tammy_Hoffmann see Tweet)

 

Richard Lehman’s weekly review

28Mar
2017

Gates Foundation announces open-access publishing venture

27Mar
2017
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