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Evidence-based Medicine

Systematic Review | Poor handling of continuous predictors in clinical prediction models using logistic regression

11 Aug, 2023 | 15:19h | UTC

Poor handling of continuous predictors in clinical prediction models using logistic regression: a systematic review – Journal of Clinical Epidemiology

 


Perspective | Creation and adoption of large language models in medicine

9 Aug, 2023 | 15:38h | UTC

Creation and Adoption of Large Language Models in Medicine – JAMA (free for a limited period)

Commentary: Rethinking large language models in medicine – Stanford Medicine

 


Perspective | Artificial-intelligence search engines wrangle academic literature

9 Aug, 2023 | 15:33h | UTC

Artificial-intelligence search engines wrangle academic literature – Nature

 


Research Letter | GPT-3.5 and GPT-4 show low accuracy in citing journal articles

9 Aug, 2023 | 15:31h | UTC

Accuracy of Chatbots in Citing Journal Articles – JAMA Network Open

 

Commentary on Twitter

 


Survey | The manifold costs of being a non-native English speaker in science

7 Aug, 2023 | 15:00h | UTC

The manifold costs of being a non-native English speaker in science – PLOS Biology

Commentary from the author: Non-native English speaking scientists work much harder just to keep up, global research reveals – The Conversation

News Releases:

The cost of being a non-native English speaker in science – PLOS

Science language barrier could cost countless careers – University of Queensland

 

Commentary on Twitter

 


Review | ‘Pragmatic’ trials changing research: Balancing traditional controls with real-world care needs

4 Aug, 2023 | 12:08h | UTC

Clinical Trials Overview: From Explanatory to Pragmatic Clinical Trials – Mayo Clinic Proceedings

Editorial: Introduction to Thematic Reviews on Forward Thinking on Clinical Trials in Clinical Practice – Mayo Clinic Proceedings

 


Perspective | The most important trial in modern cardiology (Critical appraisal of the ISCHEMIA trial)

2 Aug, 2023 | 14:11h | UTC

Chapter 3: The Most Important Trial in Modern Cardiology – Sensible Medicine

See also:

Chapter 1: What Does it Mean to Discover a Coronary Blockage? – By Dr John Mandrola

Chapter 2: On the meaning of a coronary blockage – By Dr John Mandrola

Related/Original Articles:

ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease

ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease

ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease

ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease

Follow-up of the ISCHEMIA trial | Similar survival after invasive vs. conservative management of stable coronary disease.

ISCHEMIA Trial 2ry Analysis | Patients with CCD and daily/weekly angina seem to benefit most from complete revascularization

 


Review | Futility in clinical trials

1 Aug, 2023 | 14:32h | UTC

Futility in Clinical Trials – JAMA (free for a limited period)

 


Opinion | Bad science needs to be called out: the medical profession loses trust when bad studies are used to promote policy

1 Aug, 2023 | 14:29h | UTC

Bad Science Needs to Be Called Out – Sensible Medicine

Related: Did Republicans die more during the pandemic bc they didn’t get the vax? – By Dr. Vinay Prassad

Original Study: Excess Death Rates for Republican and Democratic Registered Voters in Florida and Ohio During the COVID-19 Pandemic – JAMA Internal Medicine

 


Critical Appraisal | Did Republicans die more during the pandemic bc they didn’t get the vax?

1 Aug, 2023 | 14:28h | UTC

Did Republicans die more during the pandemic bc they didn’t get the vax? – By Dr. Vinay Prassad

Related: Bad Science Needs to Be Called Out – Sensible Medicine

Original Study: Excess Death Rates for Republican and Democratic Registered Voters in Florida and Ohio During the COVID-19 Pandemic – JAMA Internal Medicine

 


BMJ Investigation | Medical royal colleges receive millions from drug and medical devices companies

28 Jul, 2023 | 14:19h | UTC

Medical royal colleges receive millions from drug and medical devices companies – The BMJ

News Release: Medical royal colleges receive millions from drug/medical device companies – BMJ Newsroom

 

Commentary on Twitter

 


JAMA guidance for authors, peer reviewers, and editors on use of AI, language models, and chatbots

28 Jul, 2023 | 14:18h | UTC

Guidance for Authors, Peer Reviewers, and Editors on Use of AI, Language Models, and Chatbots – JAMA

See also, just published: New recommendations of the International Committee of Medical Journal Editors: use of artificial intelligence – European Heart Journal

Related

Comparing scientific abstracts generated by ChatGPT to real abstracts with detectors and blinded human reviewers – npj Digital Medicine

ChatGPT et al? Not So Fast, Say Journal Editors – TCTMD

Chat GPT will change Medicine – Vinay Prasad’s Observations and Thoughts

ChatGPT has many uses. Experts explore what this means for healthcare and medical research – The Conversation

Can artificial intelligence help for scientific writing? – Critical Care

Artificial intelligence in academic writing: a paradigm-shifting technological advance

Perspective | Generating scholarly content with ChatGPT: ethical challenges for medical publishing

ChatGPT and the future of medical writing (ChatGPT itself wrote this paper)

Nonhuman “Authors” and Implications for the Integrity of Scientific Publication and Medical Knowledge – JAMA

ChatGPT is fun, but not an author – Science

Tools such as ChatGPT threaten transparent science; here are our ground rules for their use – Nature

ChatGPT listed as author on research papers: many scientists disapprove – Nature

Abstracts written by ChatGPT fool scientists

 


New Cochrane handbook for systematic reviews of diagnostic test accuracy

25 Jul, 2023 | 14:02h | UTC

Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy – Cochrane Library

Editorial: Evaluating medical tests: introducing the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy – Cochrane Library

News Release: Introducing the new Cochrane Handbook for Diagnostic Test Accuracy – Cochrane Library

 


Perspective | Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?

24 Jul, 2023 | 13:12h | UTC

Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? – Nature

Related: Dozens of recent clinical trials may contain wrong or falsified data (free study by John Carlisle)

 

Commentary on Twitter

 


Pooled Analysis | High disease prevalence linked to increased sensitivity, decreased specificity

24 Jul, 2023 | 12:51h | UTC

The association of sensitivity and specificity with disease prevalence: analysis of 6909 studies of diagnostic test accuracy – Canadian Medical Association Journal

 


Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19

21 Jul, 2023 | 13:43h | UTC

Potential “Healthy Vaccinee Bias” in a Study of BNT162b2 Vaccine against Covid-19 – New England Journal of Medicine

 

Commentary from the author on Twitter (thread – click for more)

 


A guide and pragmatic considerations for applying GRADE to network meta-analysis

12 Jul, 2023 | 13:44h | UTC

A guide and pragmatic considerations for applying GRADE to network meta-analysis – The BMJ

 

Commentary on Twitter

 


Cohort Study | Fewer than half of new drugs add substantial therapeutic value over existing treatments

11 Jul, 2023 | 14:01h | UTC

News Release: Fewer than half of new drugs add substantial therapeutic value over existing treatments – BMJ Newsroom

Article: Therapeutic value of first versus supplemental indications of drugs in US and Europe (2011-20): retrospective cohort study – The BMJ

Editorial: Patients need better treatments, not just more of the same – The BMJ

 


GRADE guidance 36: updates to GRADE’s approach to addressing inconsistency

5 Jul, 2023 | 01:05h | UTC

GRADE guidance 36: updates to GRADE’s approach to addressing inconsistency – Journal of Clinical Epidemiology

 


Scoping Review | High correlation of positive outcomes in oncology meta-analyses with industry funding

3 Jul, 2023 | 14:21h | UTC

Scoping Review: High Correlation of Positive Outcomes in Oncology Meta-analyses with Industry Funding – JAMA Network Open

 


Perspective | Ensuring ethical postprogression therapy for patients in randomized trial control arms

28 Jun, 2023 | 13:16h | UTC

Ensuring Ethical Postprogression Therapy for Patients in Randomized Trial Control Arms – Journal of Clinical Oncology

 

Commentary on Twitter

 


Editorial | Who should judge treatment effects as unimportant?

22 Jun, 2023 | 15:05h | UTC

Who should judge treatment effects as unimportant? – Journal of Physiotherapy

 


Brief Review | Selection bias due to conditioning on a collider

21 Jun, 2023 | 13:32h | UTC

Selection bias due to conditioning on a collider – The BMJ

 


Perspective | Benefits and pitfalls of social media in cardiology

16 Jun, 2023 | 14:13h | UTC

Impact of Social Media and Multimedia Platforms: View From the JACC: Case Reports SoMe Editors – JACC: Case Reports

 

Commentary on Twitter

 


Perspective | Observational studies must be reformed before the next pandemic

15 Jun, 2023 | 15:12h | UTC

Observational studies must be reformed before the next pandemic – Nature Medicine

 


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