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NEWS - EBM & Clinical Trials

Focus on randomised clinical trials – Intensive Care Medicine (free PDF) (via @CritCareReviews)

Related: What should we stop doing in the ICU? – ICU Management & Practice (free)

“Their results add to what appears to be a constant theme in critical care, ‘less is more’ based on RCT results”

 


Alex Nowbar’s weekly research reviews, 3 December 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Assessment of Pregabalin Postapproval Trials and the Suggestion of Efficacy for New Indications: A Systematic Review – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentary: Some research may be encouraging ineffective prescriptions, says new study – McGill University (free)

“Our point is not to condemn these individual trials. Instead, we are saying that—when you zoom out and look at what’s happening at the level of the forest—the trees begin to look less healthy.” (from McGill University)

 


Ann Robinson’s research reviews, 26 November 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Alex Nowbar’s research reviews, 12 November 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Ann Robinson’s weekly research reviews, 5 November 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Alex Nowbar’s research reviews, 29 October 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Alex Nowbar’s research reviews—22 October 2018 – The BMJ Opinion (free)

Alex Nowbar reviews the latest research from the top medical journals.

 


Antidepressant withdrawal: reviewing the paper behind the headlines – The Mental Elf (free) (via @AllenFrancesMD)

Original Systematic Review: Antidepressant Withdrawal Effects (free article and commentaries)

“Last week a new review said: – Over half of people taking antidepressants experience withdrawal symptoms – These symptoms are severe in over half of cases. The press had a field day! Our blog today by @J_F_Hayes and @sameerjauhar offers a different view” (via @Mental_Elf see Tweet)

 


Many Analysts, One Data Set: Making Transparent How Variations in Analytic Choices Affect Results – Advances in Methods and Practices in Psychological Science (free) (via @f_g_zampieri)

“This is one of most important studies published this century. 29 teams used same data set to address same research question; estimated effect sizes ranged from 0.89 to 2.93 in odds-ratio units. Dramatic implications for observational research.” (via @hmkyale see Tweet)

 


Ann Robinson’s research reviews, 15 October 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Professional Societies Should Abstain From Authorship of Guidelines and Disease Definition Statements – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Professional Societies, Clinical Specialists, and Guidelines – Circulation: Cardiovascular Quality and Outcomes (free) AND Turn Cardiology Guidelines Over to Outsiders – MedPage Today (free registration required)

John Ioannidis, MD. “questioned whether cardiovascular guidelines “homogenize biased, collective, and organized ignorance” through use of predominantly “insider” experts as authors.” (from MedPage Today)

 


Zackary Berger’s journal reviews, 8 October 2018 – The BMJ Opinion (free)

Zackary Berger reviews the latest research from the top medical journals.

 


What the tests don’t show – The Washington Post (a few articles per month are free)

“Many doctors are surprisingly bad at reading test results and/or fail to grasp how false positives work. This is putting patients at risk” (via @pash22 see Tweet)

 


When Conventional Wisdom Is Put on Trial – UNDark (free) (via @EricTopol)

“The author of “Randomistas” shows how randomized trials have overturned many popular findings, from hormone therapy to the benefits of multivitamins.”

 


No more first authors, no more last authors – Nature (free)

“The controversial suggestion that we “blow up” authorship conventions to foster team, collaborative science” (via @EricTopol see Tweet)

 


Ann Robinson’s research reviews, 24 September 2018 – The BMJ Opinion (free)

Ann Robinson reviews the latest research from the top medical journals.

 


Congratulations. Your Study Went Nowhere – The New York Times (10 articles per month are free) (via @kennylinafp)

“Researchers should embrace negative results instead of accentuating the positive, which is one of several biases that can lead to bad science.”

 


Zackary Berger’s journal reviews, 17 September 2018 – The BMJ Opinion (free)

Zackary Berger reviews the latest research from the top medical journals.

 


Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free)

“All screening programs do harm, some do good as well.”

 


Guide to Statistics and Methods: Case-Control Studies: Using “Real-world” Evidence to Assess Association – JAMA (free for a limited period)

 


Publish peer reviews – Nature News (free)

“Jessica K. Polka and colleagues call on journals to sign a pledge to make reviewers’ anonymous comments part of the official scientific record.”

 


The Challenge of Reforming Nutritional Epidemiologic Research – JAMA (free for a limited period)

“…the emerging picture of nutritional epidemiology is difficult to reconcile with good scientific principles. The field needs radical reform.”

 


How Unpaywall is transforming open science – Nature News (free)

Related: Unlocking paywalled research papers (legally) (free commentaries) AND Half of papers searched for online are free to read (free)

We have been using the Unpaywall Extension for a while, and it is indeed a handy tool to find free versions (entirely legal) of paywalled articles.

 


Anti-Vaccine Activists Have Taken Vaccine Science Hostage – The New York Times (10 articles per month are free)

“Should researchers not publish findings when there’s a chance they might be misinterpreted and scare the public?” (via @NYTHealth see Tweet)

 


Richard Lehman’s journal reviews, 30 July 2018 – The BMJ Opinion (free)

Richard Lehman’s final review of the latest research in the top medical journals.

 


Richard Lehman’s journal reviews, 23 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 16 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Last Month in Oncology with Dr. Bishal Gyawali: June 2018 – eCancer News (free)

This review has an interesting opinion on changing definitions of clinically meaningful endpoints in cancer research.

 


Richard Lehman’s journal review, 9 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals

 


Hidden conflicts? – Science Magazine (free for a limited period)

““Pay-later conflicts of interest” have gone largely unnoticed & entirely unpoliced”. (via @cpiller see Tweet)

 


Richard Lehman’s journal review, 2 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Four principles to make evidence synthesis more useful for policy – Nature (free)

Related: A fresh approach to evidence synthesis – Nature (free)

“Reward the creation of analyses for policymakers that are inclusive, rigorous, transparent and accessible, urge Christl A. Donnelly and colleagues”.

 


Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free)

Related: Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

“Great new study about science outreach via Twitter: Initially, scientists mostly tweet to each other. But after accumulating about 1000 followers, scientists reach an increasing number of journalists, policy makers, and other members of the public”. (via @JSheltzer see Tweet)

 


Richard Lehman’s journal review, 25 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Core Competencies in Evidence-Based Practice for Health Professionals: Consensus Statement Based on a Systematic Review and Delphi Survey – JAMA Network Open (free)

Editorial: Interprofessional Evidence-Based Practice Competencies: Equalizing the Playing Field (free)

“68 core competencies for evidence-based practice for health professionals, developed using systematic review & Delphi consensus process” (via @hildabast see Tweet)

 


This Mediterranean diet study was hugely impactful. The science just fell apart – VOX (free)

See Related Retraction and Republication: PREDIMED Study on Mediterranean Diet (free article and commentaries)

 


Richard Lehman’s journal review, 18 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 11 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 4 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Why thousands of AI researchers are boycotting the new Nature journal – The Guardian (free)

“The public already pays taxes that fund our research. Why should people have to pay again to read the results?” (via @ashleydfarley see Tweet)

 


Richard Lehman’s journal review, 29 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s weekly journal review, 21 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 14 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Financial Conflicts of Interest Among Authors of Urology Clinical Practice Guidelines – European Urology (free)

“59% Urology Guideline writers received payments from companies AND 37% provided inaccurate COIs forms” (via @daviesbj see Tweet)

 


An introduction to systematic searching in PubMed – University of Nottingham (free)

“This course shows you how you can construct a comprehensive, systematic search strategy in PubMed to answer a clinical question” (via @CochraneUK see Tweet)

 


Richard Lehman’s journal review, 8 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 30 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Exploring the Role of Infographics for Summarizing Medical Literature – Health Professions Education (free)

“Are #infographic / #visualabstract summaries of literature preferred to abstracts? Do they decrease cognitive load? Do they increase retention? Check out our latest!” (via @Brent_Thoma see Tweet and Visual Abstract)

 


Richard Lehman’s journal review, 23 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 16 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


The Clinical Trial Is Open. The Elderly Need Not Apply – The New York Times (10 articles per month are free)

Related: Cardiac Patients in Trials Don’t Reflect Real-World Populations (link to abstract and commentaries on the subject)

“There’s a shocking lack of data on effective treatments for older people. So what do doctors do? Make guesses”. (via @NYTHealth see Tweet)

 


Richard Lehman’s journal reviews, 3 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


The Truth Wears Off: Is there something wrong with the scientific method? – The New Yorker (free)

“An excellent New Yorker article on regression to the mean. Extremely relevant to the practice of evidence-based medicine” (via @rajshekharucms see Tweet)

 


Richard Lehman’s journal reviews, 26 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Research Methods & Reporting: Analysis of cluster randomised trials with an assessment of outcome at baseline – The BMJ (free for a limited period)

 


Richard Lehman’s journal review, 19 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal reviews, 12 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Authors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)

“’The most recognized book in all of medicine’ is also rife with hidden financial conflicts. Should Harrison’s authors be disclosing $11 million in payments from drug and device makers?” (via @caseymross see Tweet)

 


Richard Lehman’s journal review, 5 March 2018 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 26 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Methodological quality and synthesis of case series and case reports – BMJ Evidence-Based Medicine (free)

“Case reports & case series can advance knowledge sometimes: here’s an article on assessing their quality, & evidence synthesis” (via @hildabast see Tweet)

 


Performance-driven culture is ruining scientific research – The Guardian (free)

“I was told impact metrics could make or break careers. Instead, they broke my faith in scientific research”.

 


Reproducibility of clinical research in critical care: a scoping review – BMC Medicine (free)

“Reproducibility in Critical Care trials from NEJM, Lancet, JAMA. Bottom line:

-Attempt to reproduce previous findings: 42%

-Original studies reported larger effects

-Inconsistency with the original: 56%” (via @otavio_ranzani see Tweet)

 


Richard Lehman’s journal reviews, 19 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal reviews, 12 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


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