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NEWS - EBM & Clinical Trials

This Mediterranean diet study was hugely impactful. The science just fell apart – VOX (free)

See Related Retraction and Republication: PREDIMED Study on Mediterranean Diet (free article and commentaries)

 


Richard Lehman’s journal review, 18 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 11 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 4 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Why thousands of AI researchers are boycotting the new Nature journal – The Guardian (free)

“The public already pays taxes that fund our research. Why should people have to pay again to read the results?” (via @ashleydfarley see Tweet)

 


Richard Lehman’s journal review, 29 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s weekly journal review, 21 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 14 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Financial Conflicts of Interest Among Authors of Urology Clinical Practice Guidelines – European Urology (free)

“59% Urology Guideline writers received payments from companies AND 37% provided inaccurate COIs forms” (via @daviesbj see Tweet)

 


An introduction to systematic searching in PubMed – University of Nottingham (free)

“This course shows you how you can construct a comprehensive, systematic search strategy in PubMed to answer a clinical question” (via @CochraneUK see Tweet)

 


Richard Lehman’s journal review, 8 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 30 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Exploring the Role of Infographics for Summarizing Medical Literature – Health Professions Education (free)

“Are #infographic / #visualabstract summaries of literature preferred to abstracts? Do they decrease cognitive load? Do they increase retention? Check out our latest!” (via @Brent_Thoma see Tweet and Visual Abstract)

 


Richard Lehman’s journal review, 23 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 16 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


The Clinical Trial Is Open. The Elderly Need Not Apply – The New York Times (10 articles per month are free)

Related: Cardiac Patients in Trials Don’t Reflect Real-World Populations (link to abstract and commentaries on the subject)

“There’s a shocking lack of data on effective treatments for older people. So what do doctors do? Make guesses”. (via @NYTHealth see Tweet)

 


Richard Lehman’s journal reviews, 3 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


The Truth Wears Off: Is there something wrong with the scientific method? – The New Yorker (free)

“An excellent New Yorker article on regression to the mean. Extremely relevant to the practice of evidence-based medicine” (via @rajshekharucms see Tweet)

 


Richard Lehman’s journal reviews, 26 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Research Methods & Reporting: Analysis of cluster randomised trials with an assessment of outcome at baseline – The BMJ (free for a limited period)

 


Richard Lehman’s journal review, 19 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal reviews, 12 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Authors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)

“’The most recognized book in all of medicine’ is also rife with hidden financial conflicts. Should Harrison’s authors be disclosing $11 million in payments from drug and device makers?” (via @caseymross see Tweet)

 


Richard Lehman’s journal review, 5 March 2018 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 26 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Methodological quality and synthesis of case series and case reports – BMJ Evidence-Based Medicine (free)

“Case reports & case series can advance knowledge sometimes: here’s an article on assessing their quality, & evidence synthesis” (via @hildabast see Tweet)

 


Performance-driven culture is ruining scientific research – The Guardian (free)

“I was told impact metrics could make or break careers. Instead, they broke my faith in scientific research”.

 


Reproducibility of clinical research in critical care: a scoping review – BMC Medicine (free)

“Reproducibility in Critical Care trials from NEJM, Lancet, JAMA. Bottom line:

-Attempt to reproduce previous findings: 42%

-Original studies reported larger effects

-Inconsistency with the original: 56%” (via @otavio_ranzani see Tweet)

 


Richard Lehman’s journal reviews, 19 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal reviews, 12 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 5 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 22 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

“25 biases affecting evidence on health kick off the new @CebmOxford Catalog of Bias” (via @hildabast see Tweet)

 


Richard Smith: The corruption of medical language – The BMJ Opinion (free)

Related: It’s not just you: science papers are getting harder to read – Nature (free) ‘It’s time to make sure research is understandable to all’ – The Telegraph (free) AND Scientific language is becoming more informal – Nature (free)

“Too often, academic journals are filled with complex language and turgid prose, which is intended not to inform the reader but to ennoble the writer”. (via @bmj_latest see Tweet)

 


USPSTF Not Backing Ankle-Brachial Index, CRP, or Coronary Calcium – MedPage Today (free registration required) AND No Change in USPSTF’s Stance on Using Nontraditional Risk Factors to Assess CV Risk – Physician’s First Watch (free)

Draft Recommendation Statement 1: Cardiovascular Disease: Risk Assessment With Nontraditional Risk Factors – USPSTF (free)

Draft Recommendation Statement 2: Peripheral Artery Disease and Cardiovascular Disease: Screening and Risk Assessment With the Ankle-Brachial Index (free)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP), or coronary artery calcification (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.

 


Can Your Hip Replacement Kill You? – The New York Times (10 articles per month are free)

“Lawsuits are pulling back the curtain on what some doctors call the Wild West of medicine: the untested and largely unregulated medical device industry” (via @NYTHealth see Tweet)

 


Richard Lehman’s journal review, 15 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Evidence Based Medicine is Easy – First10EM (free)

A simplified guide to approaching the medical literature.

 


Richard Lehman’s journal reviews, 8 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Controversies in Family Medicine: Is “Precision Medicine” Ready To Use In Primary Care Practice?

Yes: It Offers Patients More Individualized Ways of Managing Their Health – American Family Physician (free)

No: It Is Barely Ready for Testing – American Family Physician (free)

 


Richard Lehman’s journal review, 2 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


The struggle to do no harm in clinical trials – Nature (free)

“The struggle to do no harm: the unexplained deaths in #cancer immunotherapy trials” (via @EricTopol see Tweet)

 


A survey of prevalence of narrative and systematic reviews in five major medical journals – BMC Medical Research Methodology (free)

“Only 27% of the reviews in the “top 5” medical journals are systematic: another 27% are “non-systematic” & 46% are narrative but reporting a search method”. (RT @hildabast see Tweet with infographic)

 


Optimal database combinations for literature searches in systematic reviews: a prospective exploratory study – Systematic Reviews (free) (via @hildabast see Tweet)

“Optimal searches in systematic reviews should search at least Embase, MEDLINE, Web of Science, and Google Scholar as a minimum requirement to guarantee adequate and efficient coverage”.

 


The BMJ Christmas Issue – “The soul of the Christmas issue is originality. We don’t want to publish anything that resembles anything we’ve published before” (see details).

 

Original Article 1: Does Peppa Pig encourage inappropriate use of primary care resources? (free) AND Commentary: Peppa Pig might inspire unrealistic expectations of GPs – OnMedica (free)

Original Article 2 The science behind “man flu” (free) AND Commentary: Of mice and “man flu” – HealthNewsReview (free)

See also: The top six BMJ Christmas papers – Medical News Today (free) AND The BMJ Holiday Issue: Rain Doesn’t Mean More Joint Pain; Wine Glasses Getting Bigger – Physician’s First Watch (free)

 


Does Cancer Screening Save More Lives Overall? Not Necessarily – WBUR (free) (via @HealthNewsRevu see Tweet)

Related systematic review: Does screening for disease save lives in asymptomatic adults? Systematic review of meta-analyses and randomized trials – International Journal of Epidemiology (free)

“We are not suggesting that cancer screening is useless. Our critique aims to show that screening tests are like any other medical intervention: there are benefits and harms.  And it’s why we support informed decision-making”.

 


A Failure to Heal – The New York Times Magazine (10 articles per month are free) (RT @camialderighi see Tweet)

 


Our Review Criteria – HealthNewsReview (free)

“Such a great list! Ten Criteria for Reviewing a News Article on Health. Cost, harms, quality of evidence, disease-mongering, conflict of interest, etc.” (RT @CaulfieldTim see Tweet)

 


Richard Lehman’s journal review, 4 December 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Five ways to fix statistics – Nature (free)

“As debate rumbles on about how and how much poor statistics is to blame for poor reproducibility, Nature asked influential statisticians to recommend one change to improve science. The common theme? The problem is not our maths, but ourselves”.

 


Richard Lehman’s journal review, 27 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 20 November 2017 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 13 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal reviews, 6 November 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Why we need better evidence – Centre for Evidence-Based Medicine, University of Oxford (free)

“20 fundamental problems with the production of evidence” (RT @CochraneUK see Tweet)

 


Payments by US pharmaceutical and medical device manufacturers to US medical journal editors: retrospective observational study – The BMJ (free)

“Industry payments to journal editors are common and often large, particularly for certain subspecialties. Journals should consider the potential impact of such payments on public trust in published research”.

 


Richard Lehman’s journal review, 17 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 9 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Challenges in the Design and Interpretation of Noninferiority Trials – New England Journal of Medicine (free)

See also other articles in The Changing Face of Clinical Trials Series (all free)

“All too often non-inferiority clinical trials are a means of asserting false equivalence” (RT @EricTopol see Tweet)

 


Richard Lehman’s journal review, 2 October 2017 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


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