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NEWS - EBM & Clinical Trials

Screening: How overdiagnosis and other harms can undermine the benefits – Health News Review (free)

“All screening programs do harm, some do good as well.”

 


Guide to Statistics and Methods: Case-Control Studies: Using “Real-world” Evidence to Assess Association – JAMA (free for a limited period)

 


Publish peer reviews – Nature News (free)

“Jessica K. Polka and colleagues call on journals to sign a pledge to make reviewers’ anonymous comments part of the official scientific record.”

 


The Challenge of Reforming Nutritional Epidemiologic Research – JAMA (free for a limited period)

“…the emerging picture of nutritional epidemiology is difficult to reconcile with good scientific principles. The field needs radical reform.”

 


How Unpaywall is transforming open science – Nature News (free)

Related: Unlocking paywalled research papers (legally) (free commentaries) AND Half of papers searched for online are free to read (free)

We have been using the Unpaywall Extension for a while, and it is indeed a handy tool to find free versions (entirely legal) of paywalled articles.

 


Anti-Vaccine Activists Have Taken Vaccine Science Hostage – The New York Times (10 articles per month are free)

“Should researchers not publish findings when there’s a chance they might be misinterpreted and scare the public?” (via @NYTHealth see Tweet)

 


Richard Lehman’s journal reviews, 30 July 2018 – The BMJ Opinion (free)

Richard Lehman’s final review of the latest research in the top medical journals.

 


Richard Lehman’s journal reviews, 23 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 16 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Last Month in Oncology with Dr. Bishal Gyawali: June 2018 – eCancer News (free)

This review has an interesting opinion on changing definitions of clinically meaningful endpoints in cancer research.

 


Richard Lehman’s journal review, 9 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals

 


Hidden conflicts? – Science Magazine (free for a limited period)

““Pay-later conflicts of interest” have gone largely unnoticed & entirely unpoliced”. (via @cpiller see Tweet)

 


Richard Lehman’s journal review, 2 July 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Four principles to make evidence synthesis more useful for policy – Nature (free)

Related: A fresh approach to evidence synthesis – Nature (free)

“Reward the creation of analyses for policymakers that are inclusive, rigorous, transparent and accessible, urge Christl A. Donnelly and colleagues”.

 


Scientists on Twitter: Preaching to the choir or singing from the rooftops? – Facets (free)

Related: Rise of the Tweetorial – Precious Bodily Fluids (free) AND Social Medicine: Twitter in Healthcare – Journal of Clinical Medicine (free) AND University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free) AND Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)

“Great new study about science outreach via Twitter: Initially, scientists mostly tweet to each other. But after accumulating about 1000 followers, scientists reach an increasing number of journalists, policy makers, and other members of the public”. (via @JSheltzer see Tweet)

 


Richard Lehman’s journal review, 25 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Core Competencies in Evidence-Based Practice for Health Professionals: Consensus Statement Based on a Systematic Review and Delphi Survey – JAMA Network Open (free)

Editorial: Interprofessional Evidence-Based Practice Competencies: Equalizing the Playing Field (free)

“68 core competencies for evidence-based practice for health professionals, developed using systematic review & Delphi consensus process” (via @hildabast see Tweet)

 


This Mediterranean diet study was hugely impactful. The science just fell apart – VOX (free)

See Related Retraction and Republication: PREDIMED Study on Mediterranean Diet (free article and commentaries)

 


Richard Lehman’s journal review, 18 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 11 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 4 June 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Why thousands of AI researchers are boycotting the new Nature journal – The Guardian (free)

“The public already pays taxes that fund our research. Why should people have to pay again to read the results?” (via @ashleydfarley see Tweet)

 


Richard Lehman’s journal review, 29 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s weekly journal review, 21 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 14 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Financial Conflicts of Interest Among Authors of Urology Clinical Practice Guidelines – European Urology (free)

“59% Urology Guideline writers received payments from companies AND 37% provided inaccurate COIs forms” (via @daviesbj see Tweet)

 


An introduction to systematic searching in PubMed – University of Nottingham (free)

“This course shows you how you can construct a comprehensive, systematic search strategy in PubMed to answer a clinical question” (via @CochraneUK see Tweet)

 


Richard Lehman’s journal review, 8 May 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 30 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Exploring the Role of Infographics for Summarizing Medical Literature – Health Professions Education (free)

“Are #infographic / #visualabstract summaries of literature preferred to abstracts? Do they decrease cognitive load? Do they increase retention? Check out our latest!” (via @Brent_Thoma see Tweet and Visual Abstract)

 


Richard Lehman’s journal review, 23 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 16 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


The Clinical Trial Is Open. The Elderly Need Not Apply – The New York Times (10 articles per month are free)

Related: Cardiac Patients in Trials Don’t Reflect Real-World Populations (link to abstract and commentaries on the subject)

“There’s a shocking lack of data on effective treatments for older people. So what do doctors do? Make guesses”. (via @NYTHealth see Tweet)

 


Richard Lehman’s journal reviews, 3 April 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


The Truth Wears Off: Is there something wrong with the scientific method? – The New Yorker (free)

“An excellent New Yorker article on regression to the mean. Extremely relevant to the practice of evidence-based medicine” (via @rajshekharucms see Tweet)

 


Richard Lehman’s journal reviews, 26 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Research Methods & Reporting: Analysis of cluster randomised trials with an assessment of outcome at baseline – The BMJ (free for a limited period)

 


Richard Lehman’s journal review, 19 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal reviews, 12 March 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Authors of premier medical textbook didn’t disclose $11 million in industry payments – STAT (free)

“’The most recognized book in all of medicine’ is also rife with hidden financial conflicts. Should Harrison’s authors be disclosing $11 million in payments from drug and device makers?” (via @caseymross see Tweet)

 


Richard Lehman’s journal review, 5 March 2018 – The BMJ (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 26 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Methodological quality and synthesis of case series and case reports – BMJ Evidence-Based Medicine (free)

“Case reports & case series can advance knowledge sometimes: here’s an article on assessing their quality, & evidence synthesis” (via @hildabast see Tweet)

 


Performance-driven culture is ruining scientific research – The Guardian (free)

“I was told impact metrics could make or break careers. Instead, they broke my faith in scientific research”.

 


Reproducibility of clinical research in critical care: a scoping review – BMC Medicine (free)

“Reproducibility in Critical Care trials from NEJM, Lancet, JAMA. Bottom line:

-Attempt to reproduce previous findings: 42%

-Original studies reported larger effects

-Inconsistency with the original: 56%” (via @otavio_ranzani see Tweet)

 


Richard Lehman’s journal reviews, 19 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal reviews, 12 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 5 February 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Richard Lehman’s journal review, 22 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Catalogue of Bias – Centre for Evidence-Based Medicine, University of Oxford (free)

“25 biases affecting evidence on health kick off the new @CebmOxford Catalog of Bias” (via @hildabast see Tweet)

 


Richard Smith: The corruption of medical language – The BMJ Opinion (free)

Related: It’s not just you: science papers are getting harder to read – Nature (free) ‘It’s time to make sure research is understandable to all’ – The Telegraph (free) AND Scientific language is becoming more informal – Nature (free)

“Too often, academic journals are filled with complex language and turgid prose, which is intended not to inform the reader but to ennoble the writer”. (via @bmj_latest see Tweet)

 


USPSTF Not Backing Ankle-Brachial Index, CRP, or Coronary Calcium – MedPage Today (free registration required) AND No Change in USPSTF’s Stance on Using Nontraditional Risk Factors to Assess CV Risk – Physician’s First Watch (free)

Draft Recommendation Statement 1: Cardiovascular Disease: Risk Assessment With Nontraditional Risk Factors – USPSTF (free)

Draft Recommendation Statement 2: Peripheral Artery Disease and Cardiovascular Disease: Screening and Risk Assessment With the Ankle-Brachial Index (free)

“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP), or coronary artery calcification (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.

 


Can Your Hip Replacement Kill You? – The New York Times (10 articles per month are free)

“Lawsuits are pulling back the curtain on what some doctors call the Wild West of medicine: the untested and largely unregulated medical device industry” (via @NYTHealth see Tweet)

 


Richard Lehman’s journal review, 15 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Evidence Based Medicine is Easy – First10EM (free)

A simplified guide to approaching the medical literature.

 


Richard Lehman’s journal reviews, 8 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


Controversies in Family Medicine: Is “Precision Medicine” Ready To Use In Primary Care Practice?

Yes: It Offers Patients More Individualized Ways of Managing Their Health – American Family Physician (free)

No: It Is Barely Ready for Testing – American Family Physician (free)

 


Richard Lehman’s journal review, 2 January 2018 – The BMJ Opinion (free)

Richard Lehman reviews the latest research in the top medical journals.

 


The struggle to do no harm in clinical trials – Nature (free)

“The struggle to do no harm: the unexplained deaths in #cancer immunotherapy trials” (via @EricTopol see Tweet)

 


A survey of prevalence of narrative and systematic reviews in five major medical journals – BMC Medical Research Methodology (free)

“Only 27% of the reviews in the “top 5” medical journals are systematic: another 27% are “non-systematic” & 46% are narrative but reporting a search method”. (RT @hildabast see Tweet with infographic)

 


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