Open access


Circulating vitamin D concentration and risk of seven cancers: Mendelian randomisation study – The BMJ (free)

Commentary: Vitamin D level not associated with cancer risk – Clinical Adviser (free)

“These results, in combination with previous literature, provide evidence that population-wide screening for vitamin D deficiency and subsequent widespread vitamin D supplementation should not currently be recommended as a strategy for primary cancer prevention”.


Incidence, Demographics, and Clinical Characteristics of Diabetes of the Exocrine Pancreas (Type 3c): A Retrospective Cohort Study – Diabetes Care (link to abstract – $ for full-text)

Commentary: Newly-identified third type of diabetes is being wrongly diagnosed as type 2 – The Conversation (free)

“Diabetes of the exocrine pancreas is frequently labeled type 2 diabetes but has worse glycemic control and a markedly greater requirement for insulin”.


Concurrent bariatric operations and association with perioperative outcomes: registry based cohort study – The BMJ (free)

“Concurrent bariatric operations occurred infrequently, but when they did, there was no observable increased risk for adverse perioperative outcomes compared with non-concurrent operations”.


52-week programme leads to more weight loss than 12-week – NIHR Signal (free)

Original article: Extended and standard duration weight-loss programme referrals for adults in primary care (WRAP): a randomised controlled trial – The Lancet (free) AND Commentary: Weight management programmes of extended duration (free)

“Although short-term costs higher, referring people to a 52-week programme is probably more cost-effective long-term” (RT @NIHR_DC see Tweet)


Incidence, Demographics, and Clinical Characteristics of Diabetes of the Exocrine Pancreas (Type 3c): A Retrospective Cohort Study – Diabetes Care (link to abstract – $ for full-text)

Commentary: Glycemic control poor, insulin use high in diabetes after pancreatic disease – Haelio (free registration required)

“Diabetes following pancreatic disease associated with poor glycemic control compared with T2 diabetes” (RT @kamleshkhunti see Tweet)


New Nutrition Study Changes Nothing – The Atlantic (free) (RT @drjohnm see Tweet)

See original article and commentaries in our August 30 issue (see #1 and #2)

“Why the science of healthy eating appears confusing – but isn’t”


Public Health Guideline: Vitamin D: supplement use in specific population groups – National Institute for Health and Care Excellence (NICE) (free)

“Only test vitamin D status if someone has symptoms of deficiency or is at very high risk”


Cognitive Function in a Randomized Trial of Evolocumab – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Cholesterol-Lowering Drug Evolocumab Doesn’t Seem to Impair Cognition – Physician’s First Watch (free)

“The authors caution that most people take cholesterol-lowering medications for decades, and this was a much shorter follow-up period” (from Physician’s First Watch).


Effects of Anacetrapib in Patients with Atherosclerotic Vascular Disease – New England Journal of Medicine (free)

Commentaries: Anacetrapib REVEALs ‘Modest’ Effect on Cardiovascular Outcomes – Medscape (free registration required) AND Anacetrapib Finds (Modest) Success Where All Other CETP Inhibitors Failed – TCTMD (free) AND REVEAL Revealed: A Slightly Positive CETP Inhibitor Trial – Cardiobrief (free)

Interesting new drug, but with modest benefits. During the median follow-up period of 4.1 years, the primary outcome occurred in fewer patients in the anacetrapib group than in the placebo group (10.8% vs. 11.8% / absolute risk difference = 1%, meaning 100 patients would have to be treated for 4.1 years to benefit 1 patient)


Diabetes and Hypertension: A Position Statement by the American Diabetes Association (free) (RT @Abraham_RMI and @ADA_Journals see Tweet)

Commentary: ADA Offers Position Statement on Diabetes and Hypertension – AJMC (free)

“the guideline continues the advice that most patients with diabetes should be treated to a blood pressure goal of <140/90 mm Hg; a goal of <130/80 can be considered for patients who have other cardiovascular risk factors” (from AJMC)


Study: diet soda can really mess with your metabolism – VOX (free)

Original article: Integration of Sweet Taste and Metabolism Determines Carbohydrate Reward – Current Biology (link to abstract – $ for full-text)

See also a related meta-analysis showing little evidence of artificial sweeteners for weight loss in our July 18th issue (see #2)

“New research helps explain why artificial sweeteners are linked to obesity and metabolic disease”.


The 10-Year Prognostic Value of Zero and Minimal CAC – Journal of The American College of Cardiology (no abstract – $ for full text)

Commentary: Calcium in Arteries Influences Heart Attack Risk –  UT Southwestern Medical Center, via NewsWise (free) AND Study: Calcium in arteries influences heart attack risk – UPI (free)

“Half of the participants had no calcium deposits in their arteries or a zero coronary artery calcium, or CAC, score, and had less than a 3 percent chance of a cardiovascular event over a 10-year period despite having other risk factors for heart disease and stroke such as type 2 diabetes, high blood pressure and high bad cholesterol levels” (from UPI)


All-Cause and Specific-Cause Mortality Risk After Roux-en-Y Gastric Bypass in Patients With and Without Diabetes (link to abstract – $ for full-text)

Commentary: Gastric Bypass Sharply Lowers Death Risk for People With Diabetes, Study Finds – AJMC (free)

Case-control study suggests the procedure may reduce the risk of death in patients with diabetes.


New insulin pumps offer continuous monitoring – ACP Internist (free)

Related article: Home use of a bihormonal bionic pancreas versus insulin pump therapy in adults with type 1 diabetes: a multicentre randomised crossover trial – The Lancet (free PDF)

“Next-generation insulin pumps will feature sophisticated computer algorithms that automatically calculate and administer precise doses of insulin…”


Diabetic retinopathy: current understanding, mechanisms, and treatment strategies – JCI Insight (free)

“It affects 100 M people WW, but under-diagnosed/treated: excellent review of diabetes retinopathy” (RT @EricTopol see Tweet)


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