Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Dulaglutide Cuts Cardiovascular Risk in Type 2 Diabetes – NEJM Journal Watch (free)

During a median follow-up of 5.4 years, the primary outcome (a composite endpoint of non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular causes) occurred in 12.0% of participants in the dulaglutide group and in 13.4% of participants in the placebo group (incidence rate of 2.4 per 100 person-years vs 2.7 per 100 person-years in the placebo group).


Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients – The BMJ (free for a limited period)


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Review: Menopausal Hormone Therapy

31 May, 2019 | 06:30h | UTC

Menopausal Hormone Therapy – JAMA (free for a limited period)

Podcast: Menopausal Hormone Therapy (free audio)


Review: Diabetes and Bone

23 May, 2019 | 13:13h | UTC

Recent advances in diabetes treatments and their perioperative implications – Current Opinion in Anesthesiology (free)

Source: Critical Care Reviews Newsletter

“Sulfonylureas and SGLT2i should be ceased before moderate or major surgery. Other oral antihyperglycemic therapies may be continued or ceased.


Efficacy of population‐wide diabetes and obesity prevention programs: An overview of systematic reviews on proximal, intermediate, and distal outcomes and a meta‐analysis of impact on BMI – Obesity Reviews (free)


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Clinical Update: Metformin in 2019

23 Apr, 2019 | 01:50h | UTC

Metformin in 2019 – JAMA (free for a limited period)


Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus – Nutrients (free)

The authors acknowledge the almost non-existent evidence on this issue and suggest practical recommendations for the care of these patients.


Latest Updates on Lipid Management

21 Apr, 2019 | 21:14h | UTC

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: Evidence Supporting Niacin Use for Cardiovascular Disease Prevention Evaluated – MPR (free) AND Niacin: Time to Revisit That FDA Indication – MedPage Today (free registration required)


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Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (free for a limited period)

Commentary: Canagliflozin may offer renal protection in people with type 2 diabetes and CKD – Medicine Matters (free)

“among 1000 patients treated for 2.5 years, 21.2 individuals would need to be treated to prevent the composite primary outcome.” (from Medicine Matters)


Use of vitamin D drops leading to kidney failure in a 54-year-old man – Canadian Medical Association Journal (free)

“Vitamin D toxicity is rare, but clinicians must be aware of the risks of vitamin D use to limit complications related to hypercalcemia”.


Thyrotoxicosis: Diagnosis and Management

26 Mar, 2019 | 01:43h | UTC

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality – JAMA (free for a limited period)

Commentaries: Are Eggs Good Or Bad? How You Should Interpret This Latest Study – Forbes (free) AND Are eggs good or bad for you? New research rekindles the debate – STAT (free) AND Eggs are bad – then good – then bad again? What gives? – Diet Doctor (free)


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Evidence evolving on aspirin as prevention – ACP Internist (free)

Related: Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease (link to abstract and commentaries) AND Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes (link to abstract and commentaries) AND Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly (link to abstract and commentaries) AND Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events (link to abstract and commentaries)

“In patients who have not had a prior cardiovascular event, aspirin’s protective effects are modest and may not necessarily outweigh its potential downsides (namely, risk of bleeding and hemorrhagic stroke).”


Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults – JAMA (free for a limited period)

“This Viewpoint discusses the 2018 ACC/AHA cholesterol management guideline recommendation to consider statin treatment in adults aged >75 years with LDL levels 70-189 mg/dL, arguing that trial evidence does not support it…”


Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: nationwide case-control study – The BMJ (free)

Editorial: Menopausal hormone therapy and cognition (free)

Commentaries: Systemic Hormone Therapy Tied to Small Increase in Alzheimer’s Risk – NEJM Journal Watch (free) AND ‘Small’ increase in risk of Alzheimer’s disease with HRT use, study suggests – NHS Choices (free)

“The findings of this case-control study, with the modest effect sizes and substantial potential for bias, will not change how I counsel patients regarding benefits and risks of HT.” (from Journal Watch)

“Evidence is reassuring for women needing a few years’ treatment for menopausal symptoms” (from Editorial)


The war on ‘prediabetes’ could be a boon for pharma—but is it good medicine? – Science (free)


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Review: Glucose Control in the ICU

6 Mar, 2019 | 01:27h | UTC

Is interval training the magic bullet for fat loss? A systematic review and meta-analysis comparing moderate-intensity continuous training with high-intensity interval training (HIIT) – British Journal of Sports Medicine (link to abstract – $ for full-text)

Commentaries: The Best Type of Exercise to Burn Fat – The New York Times (10 articles per month are free) AND Short bursts of intense exercise ‘better for weight loss’ – BBC (free) AND Short intense exercise regimes may aid weight loss – OnMedica (free)


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Incidence of sight‐threatening diabetic retinopathy in people with Type 2 diabetes mellitus and numbers needed to screen: a systematic review – Diabetic Medicine (free PDF)

Commentary: How often should patients with T2D be screened for retinopathy? – Univadis (free registration required)

Related: Evidence‐based Guidelines for Screening of Diabetic Retinopathy (free)

“This review supports lengthening of the screening interval of patients with Type 2 diabetes without retinopathy at last screening session”


Worldwide Dyslipidemia Guidelines

4 Feb, 2019 | 22:32h | UTC

Implementation of a Health Plan Program for Switching From Analogue to Human Insulin and Glycemic Control Among Medicare Beneficiaries With Type 2 Diabetes – JAMA (link to abstract – $ for full-text)

Commentary: Medicare Patients with Type 2 Diabetes Safely Switched From Analog to Human Insulin, JAMA Study Finds – AJMC (free)

Related: Meta-Analysis: Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes (link to abstract and commentaries) AND Retrospective Observational Study: Basal Insulin Analogs vs NPH Insulin for Type 2 Diabetes (link to abstract and commentaries)

“Patients with type 2 diabetes (T2D) enrolled in a CareMore Health Medicare Part D plan switched from analog to human insulin without significant loss of glycemic control while saving millions for themselves and for the health plan.: (from AJMC)


New Canada’s Dietary Guidelines

23 Jan, 2019 | 01:25h | UTC

Canada’s Dietary Guidelines – Government of Canada (free)

Homepage: Canada’s Food Guide (free resources)


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Evidence‐based Danish guidelines for screening of diabetic retinopathy – Acta Ophthalmologica (free)

“There is solid evidence to support a flexible, individualized screening regimen. In particular, it is possible to prolong screening intervals to 24–48 months for patients with no or mild nonproliferative diabetic retinopathy”.


Food in the Anthropocene: the EAT–Lancet Commission on healthy diets from sustainable food systems – The Lancet (free articles – registration required)

Summary: EAT-Lancet Commission Brief for Everyone (free)

Commentaries: New Diet Guidelines to Benefit People and the Planet: More Greens for All, Less Meat for Some – The New York Times (10 articles per month are free) AND New ‘planetary health diet’ can save lives and the planet, major review suggests – CNN (free) AND A bit of meat, a lot of veg – the flexitarian diet to feed 10bn – BBC (free)


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Carbohydrate quality and human health: a series of systematic reviews and meta-analyses – The Lancet (link to abstract – $ for full-text)

Commentaries: High intake of dietary fiber and whole grains associated with reduced risk of non-communicable diseases – ScienceDaily (free) AND High-fiber diet linked to lower risk of death and chronic diseases – CNN (free) AND Expert reaction to series of systematic reviews and meta-analyses about dietary fibre and the risk of non-communicable disease – Science Media Centre (free)


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Short‐acting insulin analogues versus regular human insulin for adult, non‐pregnant persons with type 2 diabetes mellitus – Cochrane Library (free)

Summary: Short-acting insulin analogues versus regular human insulin for type 2 diabetes mellitus – Cochrane Library (free)

“The current evidence from clinical trials suggests neither clear benefits nor clear harms from the use of short‐acting insulin analogues over regular human insulin.”