Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ (free)

Related: Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention (link to abstract and commentary) AND NICE Guideline: Vitamin D Supplementation (free)

Vitamin D supplementation was not associated with all-cause mortality, cardiovascular mortality, or non-cancer, non-cardiovascular mortality. However, Vitamin D supplementation statistically significantly reduced the risk of cancer death by 16%.


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Long-term adverse events after sleeve gastrectomy or gastric bypass: a 7-year nationwide, observational, population-based, cohort study – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)

Commentary: Death Risk Drops After Bariatric Surgery in Obese Patients – MedPage Today (free registration required)

Related Research: Association of Bariatric Surgery vs Usual Care Obesity Management With All-Cause Mortality (free study and commentaries)


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Medications Affecting the Biochemical Conversion to Type 2 Diabetes: A Systematic Review and Meta-Analysis – The Journal of Clinical Endocrinology & Metabolism (free)

α-Glucosidase inhibitors, angiotensin-converting enzyme inhibitors, angiotensin II receptor blockers, metformin, orlistat, phentermine/topiramate, and pioglitazone significantly reduced the risk of biochemical conversion to T2DM, whereas statins and nateglinide increased the risk”


Diagnosing the Onset of Menopause

23 Jul, 2019 | 01:47h | UTC

Diagnosing the Onset of Menopause – JAMA (free for a limited period)

Clinical Review Audio: Diagnosing Menopause (free)


Clinical Use of Bone Turnover Markers

14 Jul, 2019 | 19:15h | UTC

Clinical Use of Bone Turnover Markers – JAMA (free for a limited period)


Review: Subclinical Hypothyroidism

10 Jul, 2019 | 02:36h | UTC

Subclinical Hypothyroidism – A Review – JAMA (free link for a limited period)

Related: BMJ Guideline: Treatment of Subclinical Hypothyroidism (free guideline and commentaries)


Vitamin D Supplementation and Cardiovascular Disease Risks in More Than 83 000 Individuals in 21 Randomized Clinical Trials: A Meta-analysis – JAMA Cardiology (free for a limited period)

Commentaries: The Demise of Vitamin D for Cardiovascular Prevention – JAMA Cardiology (free for a limited period) AND Does Vitamin D Supplementation Provide Cardiovascular Protection? – MPR (free)


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Dulaglutide and cardiovascular outcomes in type 2 diabetes (REWIND): a double-blind, randomised placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Dulaglutide Cuts Cardiovascular Risk in Type 2 Diabetes – NEJM Journal Watch (free)

During a median follow-up of 5.4 years, the primary outcome (a composite endpoint of non-fatal myocardial infarction, non-fatal stroke, or death from cardiovascular causes) occurred in 12.0% of participants in the dulaglutide group and in 13.4% of participants in the placebo group (incidence rate of 2.4 per 100 person-years vs 2.7 per 100 person-years in the placebo group).


Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients – The BMJ (free for a limited period)


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Review: Menopausal Hormone Therapy

31 May, 2019 | 06:30h | UTC

Menopausal Hormone Therapy – JAMA (free for a limited period)

Podcast: Menopausal Hormone Therapy (free audio)


Review: Diabetes and Bone

23 May, 2019 | 13:13h | UTC

Recent advances in diabetes treatments and their perioperative implications – Current Opinion in Anesthesiology (free)

Source: Critical Care Reviews Newsletter

“Sulfonylureas and SGLT2i should be ceased before moderate or major surgery. Other oral antihyperglycemic therapies may be continued or ceased.


Efficacy of population‐wide diabetes and obesity prevention programs: An overview of systematic reviews on proximal, intermediate, and distal outcomes and a meta‐analysis of impact on BMI – Obesity Reviews (free)


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Clinical Update: Metformin in 2019

23 Apr, 2019 | 01:50h | UTC

Metformin in 2019 – JAMA (free for a limited period)


Clinical Management of Intermittent Fasting in Patients with Diabetes Mellitus – Nutrients (free)

The authors acknowledge the almost non-existent evidence on this issue and suggest practical recommendations for the care of these patients.


Latest Updates on Lipid Management

21 Apr, 2019 | 21:14h | UTC

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: Evidence Supporting Niacin Use for Cardiovascular Disease Prevention Evaluated – MPR (free) AND Niacin: Time to Revisit That FDA Indication – MedPage Today (free registration required)


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Canagliflozin and Renal Outcomes in Type 2 Diabetes and Nephropathy – New England Journal of Medicine (free for a limited period)

Commentary: Canagliflozin may offer renal protection in people with type 2 diabetes and CKD – Medicine Matters (free)

“among 1000 patients treated for 2.5 years, 21.2 individuals would need to be treated to prevent the composite primary outcome.” (from Medicine Matters)


Use of vitamin D drops leading to kidney failure in a 54-year-old man – Canadian Medical Association Journal (free)

“Vitamin D toxicity is rare, but clinicians must be aware of the risks of vitamin D use to limit complications related to hypercalcemia”.


Thyrotoxicosis: Diagnosis and Management

26 Mar, 2019 | 01:43h | UTC

Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality – JAMA (free for a limited period)

Commentaries: Are Eggs Good Or Bad? How You Should Interpret This Latest Study – Forbes (free) AND Are eggs good or bad for you? New research rekindles the debate – STAT (free) AND Eggs are bad – then good – then bad again? What gives? – Diet Doctor (free)


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Evidence evolving on aspirin as prevention – ACP Internist (free)

Related: Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease (link to abstract and commentaries) AND Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes (link to abstract and commentaries) AND Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly (link to abstract and commentaries) AND Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events (link to abstract and commentaries)

“In patients who have not had a prior cardiovascular event, aspirin’s protective effects are modest and may not necessarily outweigh its potential downsides (namely, risk of bleeding and hemorrhagic stroke).”


Reexamining Recommendations for Treatment of Hypercholesterolemia in Older Adults – JAMA (free for a limited period)

“This Viewpoint discusses the 2018 ACC/AHA cholesterol management guideline recommendation to consider statin treatment in adults aged >75 years with LDL levels 70-189 mg/dL, arguing that trial evidence does not support it…”


Use of postmenopausal hormone therapy and risk of Alzheimer’s disease in Finland: nationwide case-control study – The BMJ (free)

Editorial: Menopausal hormone therapy and cognition (free)

Commentaries: Systemic Hormone Therapy Tied to Small Increase in Alzheimer’s Risk – NEJM Journal Watch (free) AND ‘Small’ increase in risk of Alzheimer’s disease with HRT use, study suggests – NHS Choices (free)

“The findings of this case-control study, with the modest effect sizes and substantial potential for bias, will not change how I counsel patients regarding benefits and risks of HT.” (from Journal Watch)

“Evidence is reassuring for women needing a few years’ treatment for menopausal symptoms” (from Editorial)


The war on ‘prediabetes’ could be a boon for pharma—but is it good medicine? – Science (free)


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Review: Glucose Control in the ICU

6 Mar, 2019 | 01:27h | UTC

Is interval training the magic bullet for fat loss? A systematic review and meta-analysis comparing moderate-intensity continuous training with high-intensity interval training (HIIT) – British Journal of Sports Medicine (link to abstract – $ for full-text)

Commentaries: The Best Type of Exercise to Burn Fat – The New York Times (10 articles per month are free) AND Short bursts of intense exercise ‘better for weight loss’ – BBC (free) AND Short intense exercise regimes may aid weight loss – OnMedica (free)


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Incidence of sight‐threatening diabetic retinopathy in people with Type 2 diabetes mellitus and numbers needed to screen: a systematic review – Diabetic Medicine (free PDF)

Commentary: How often should patients with T2D be screened for retinopathy? – Univadis (free registration required)

Related: Evidence‐based Guidelines for Screening of Diabetic Retinopathy (free)

“This review supports lengthening of the screening interval of patients with Type 2 diabetes without retinopathy at last screening session”