Critical Care & Emergencies

Effects of Percutaneous Coronary Intervention on Death and Myocardial Infarction Stratified by Stable and Unstable Coronary Artery Disease: A Meta-Analysis of Randomized Controlled Trials – Circulation: Cardiovascular Quality and Outcomes (free)

Editorial: The ISCHEMIA Trial Meets the Rashomon Effect: Lessons for Clinical Practice (free for a limited period)

 

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Nonsedation or Light Sedation in Critically Ill, Mechanically Ventilated Patients – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: No Sedation: An Option in Mechanically Ventilated ICU Patients – MedPage Today (free registration required)

 

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Empirical Anti-MRSA vs Standard Antibiotic Therapy and Risk of 30-Day Mortality in Patients Hospitalized for Pneumonia – JAMA Internal Medicine (free for a limited period)

Editorial: Overuse of Broad-Spectrum Antibiotics for Pneumonia (free for a limited period)

 

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Management of acute ischemic stroke – The BMJ (free for a limited period)

 


Management of Acute Asthma in Adults in 2020 – JAMA (free for a limited period)

Related Article: Outpatient Management of Chronic Asthma in 2020 – JAMA (free for a limited period)

Editorial: New Therapeutic Strategies for Asthma – JAMA (free for a limited period)

 


Effect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Choosing the Best Blood Pressure Target for Vasopressor Therapy (free for a limited period)

Conference Presentation: Effect of Reduced Vasopressor Exposure on Mortality in Older Critically Ill Patients With Vasodilatory Hypotension (free)

 

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Association of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock – JAMA (free for a limited period)

Editorial: Microaxial Left Ventricular Assist Devices: In Search of an Appropriate Indication (free for a limited period)

Commentary: High-tech pump may increase risk of death and bleeding, study finds – Yale News (free)

 

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Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Related: Meta-Analysis: Assessment of Therapeutic Interventions and Lung Protective Ventilation in Patients with Moderate to Severe Acute Respiratory Distress Syndrome (free resources on the subject)

 

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Blood Pressure Thresholds and Neurologic Outcomes After Endovascular Therapy for Acute Ischemic Stroke: An Analysis of Individual Patient Data From 3 Randomized Clinical Trials – JAMA Neurology (link to abstract – $ for full-text)

Commentary: ‘Sweet Spot’ Identified for BP During Stroke Thrombectomy – TCTMD (free) AND Blood Pressure Key to Good Outcomes in Stroke Thrombectomy – Medscape (free registration required)

 

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Guidelines for the management of glucocorticoids during the peri‐operative period for patients with adrenal insufficiency – Anaesthesia (free)

 

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Electrical versus pharmacological cardioversion for emergency department patients with acute atrial fibrillation (RAFF2): a partial factorial randomised trial – The Lancet (link to abstract – $ for full-text)

Summary: Electrical vs Chemical Cardioversion in ED Patients With Atrial Fibrillation (RAFF2) – EMOttawa (free)

Related Study: Randomized Trial: Early vs. Delayed Cardioversion in Recent-Onset Atrial Fibrillation – New England Journal of Medicine (free study and commentaries)

 

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Study Commentary: PEPTIC

2 Feb, 2020 | 19:47h | UTC

Perspective: CPR, by Default

2 Feb, 2020 | 19:45h | UTC

CPR, by Default – The New York Times (10 articles per month are free)

 


Andromeda and ‘appalling science’: a response to Hardwicke and Ioannidis – Winton Centre for Risk and Evidence Communication (free)

 

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Podcast: Dialysis for the Internist

28 Jan, 2020 | 09:04h | UTC

Severe Flu Management: A Point of View

23 Jan, 2020 | 09:42h | UTC

Effect of Hydroxyethyl Starch vs Saline for Volume Replacement Therapy on Death or Postoperative Complications Among High-Risk Patients Undergoing Major Abdominal Surgery: The FLASH Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Hydroxyethyl Starch for Fluid Replacement Therapy in High-Risk Surgical Patients: Context and Caution (free for a limited period)

Related Cochrane Review: Colloids vs Crystalloids for Fluid Resuscitation in Critically Ill People (free)

 

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Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study – The Lancet (free)

Commentaries: A global accounting of sepsis – The Lancet (free) AND Sepsis associated with 1 in 5 deaths globally, double previous estimate – Institute for Health Metrics and Evaluation (free)

 

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NICE Guideline: Acute Kidney Injury

5 Jan, 2020 | 14:22h | UTC

Effect of Rocuronium vs Succinylcholine on Endotracheal Intubation Success Rate Among Patients Undergoing Out-of-Hospital Rapid Sequence Intubation: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Newer Drug Falls Short for Quick Prehospital Intubation – MedPage Today (free registration required)

 

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Effect of a Strategy of Comprehensive Vasodilation vs Usual Care on Mortality and Heart Failure Rehospitalization Among Patients With Acute Heart Failure: The GALACTIC Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: No Survival Gain From Aggressive Vasodilator Strategy in Acute HF: GALACTIC – Medscape (free registration required)

 

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Surgeons withdraw support for heart disease advice – BBC (free)

YouTube Video: European guidelines on heart disease under review – BBC Newsnight (free)

See also: EACTS responds to BBC Newsnight’s investigation on the EXCEL trial – European Association for Cardio-Thoracic Surgery (free)

Commentary: EACTS Pulls Out of Left Main Guidelines After BBC Bombshell Alleging EXCEL Trial Cover-up – TCTMD (free)

 

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Homepage: CPR Guidelines (free summaries and infographics)

– 2019 Highlights – Guidelines Update for CPR & ECC

– 2019 FAQ – Guidelines Update for CPR & ECC

– 2019 Infographic – ACLS Guidelines Update

– 2019 Infographic – PALS Guidelines Update

Original Guidelines: AHA Updates on Advanced Cardiovascular Life Support (ACLS) (free) AND AHA Updates in Pediatric Life Support (free)

 

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The effect of remote ischaemic preconditioning on myocardial injury in emergency hip fracture surgery (PIXIE trial): phase II randomised clinical trial – The BMJ (free)

Related Perspective: Remote ischaemic preconditioning: an intervention for anaesthetists? – British Journal of Anaesthesia (free)

 

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Management of severe acute pancreatitis – The BMJ (free for a limited period)

Related Guidelines: 2019 WSES guidelines for the management of severe acute pancreatitis – World Journal of Emergency Surgery (free) AND American Gastroenterological Association Institute Guideline on Initial Management of Acute Pancreatitis (free) AND Pancreatitis – National Institute for Health and Care Excellence (free) AND American College of Gastroenterology Guideline: Management of Acute Pancreatitis (free)

 

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Guidelines for safe transfer of the brain‐injured patient: trauma and stroke, 2019 – Anaesthesia (free)

 

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Randomized Trial of Three Anticonvulsant Medications for Status Epilepticus – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Head-to-head comparison finds three anti-seizure drugs equally effective for severe form of epilepsy – NIH News Release (free)

 

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Toward Increased Understanding of the Steroid Controversy in Septic Shock – Critical Care Medicine (free)

See also: Why Understanding Sepsis Endotypes Is Important for Steroid Trials in Septic Shock (free) AND Why the Adjunctive Corticosteroid Treatment in Critically Ill Patients With Septic Shock (ADRENAL) Trial Did Not Show a Difference in Mortality (free) AND Why My Steroid Trials in Septic Shock Were “Positive” (free)

Related: Review: Adjunctive Corticosteroid Treatment in Septic Shock (free review, guideline, and meta-analysis on the subject)

 

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Evaluating a digital sepsis alert in a London multisite hospital network: a natural experiment using electronic health record data – Journal of the American Medical Informatics Association (free)

Commentary: Digital monitoring system helps improve hospital care of sepsis patients – OnMedica (free) AND Sepsis digital alert ‘led to faster treatment with antibiotics’ – BBC (free)

 

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Bedside Optic Nerve Ultrasonography for Diagnosing Increased Intracranial Pressure: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Bedside optic nerve ultrasonography may be useful for measuring intracranial pressure – ACP Hospitalist (free) AND Optic Nerve Ultrasound May ID Increased Intracranial Pressure – Physician’s Briefing (free)

 

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Difficult Airway Society guidelines for awake tracheal intubation (ATI) in adults – Anaesthesia (free)

 

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Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Colchicine Cardiovascular Outcomes Trial – COLCOT – American College of Cardiology (free) AND COLCOT Renews Hope for Anti-inflammatory in Secondary Prevention: Colchicine – TCTMD (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Intensivist Burnout: Running on Empty?

18 Nov, 2019 | 00:26h | UTC

UPDATE: The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication – U.S Food and Drug Administration (free)

Commentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)

“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”