Critical Care & Emergencies

Effect of a fluid bolus on cardiovascular collapse among critically ill adults undergoing tracheal intubation (PrePARE): a randomised controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Source: Critical Care Reviews Newsletter


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Review: Ultrasonography of the Lung

10 Oct, 2019 | 09:07h | UTC

Podcast: In-Flight Emergencies

8 Oct, 2019 | 10:06h | UTC

Medical Management vs Mechanical Thrombectomy for Mild Strokes: An International Multicenter Study and Systematic Review and Meta-analysis – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Medical Therapy Vs Endovascular Therapy: Similar Outcomes for Mild Strokes – Neurology Today (free) AND Similar Benefits for Thrombectomy, Medical Management, in Mild Stroke – Medscape (free)


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Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients (free for a limited period)



Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Is High-Dose Vitamin C Beneficial for Patients With Sepsis? (free)

Commentary: ‘Tantalizing’ Results For A Test Of Vitamin C For Sepsis – NPR (free)

In exploratory analyses that did not adjust for multiple comparisons, 3 secondary outcomes (out of 46 examined) were significantly different between groups. At day 28, mortality was 46.3% (38/82) in the placebo group vs 29.8% (25/84) in the vitamin C group (P = .03). The number of ICU-free days to day 28 was 10.7 in the vitamin C group vs 7.7 in the placebo group (P = .03). The number of hospital-free days in the vitamin C group vs the placebo group was 22.6 vs 15.5, respectively (P = .04).


Protocolised non-invasive compared with invasive weaning from mechanical ventilation for adults in intensive care – Health Technology Assessment (free)

Source: Critical Care Reviews Newsletter

“A protocolized non-invasive weaning strategy did not reduce time to liberation from ventilation. However, patients who underwent non-invasive weaning had fewer days requiring IMV and required fewer antibiotics for respiratory infections.”


What Is Known About Candida auris – JAMA (free for a limited period)

Related: Global Epidemiology of Emerging Candida Auris (reviews and commentaries on the subject)


Chlorhexidine bathing of the critically ill for the prevention of hospital‐acquired infection – Cochrane Library (free)

Summary: Bathing critically ill patients with chlorhexidine to prevent hospital-acquired infections – Cochrane Library (free)

“Due to the very low-certainty evidence available, it is not clear whether bathing with chlorhexidine reduces hospital-acquired infections, mortality, or length of stay in the ICU”


The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC): Developed in collaboration with the Association for European Paediatric and Congenital Cardiology (AEPC) (free)


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Maximum-fixed energy shocks for cardioverting atrial fibrillation – European Heart Journal (free)

Commentary: Comparison of High vs. Escalating Shocks – CHESS – American College of Cardiology (free)


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Commentaries: HiSTORIC Trial Supports Single-Test Rule-Out of MI Using High-Sensitivity Troponin – TCTMD (free) AND Risk-Based Thresholds for hs-Troponin I Safely Speed MI Rule-Out – MedPage Today (free registration required) AND HISTORIC: Early Rule-Out Strategy Using High-Sensitivity Cardiac Troponin I Reduced Length of Stay, Hospital Readmissions in Suspected ACS Patients – American College of Cardiology (free)

Related Studies: Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival (free study and commentaries)


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Lazarus in asystole: a case report of autoresuscitation after prolonged cardiac arrest – European Heart Journal Case Reports (free)


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Perioperative covert stroke in patients undergoing non-cardiac surgery (NeuroVISION): a prospective cohort study – The Lancet (link to abstract – $ for full-text)

Commentaries: ‘Silent’ strokes common after surgery, linked to cognitive decline – McMaster University (free) AND ‘Silent’ strokes after elective surgeries in older adults double their risk of later cognitive decline, study finds – The Globe and Mail (free)


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Comparison of Oral Ibuprofen at Three Single-Dose Regimens for Treating Acute Pain in the Emergency Department: A Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)

Commentary: Don’t Use More Than 400 mg of Ibuprofen for Pain Control – NEJM Journal Watch (free for a limited period)


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Podcast: Stroke and TIA Deconstructed

6 Aug, 2019 | 08:04h | UTC

Artificial intelligence in intensive care: are we there yet? – Intensive Care Medicine (free PDF)


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Digoxin Discontinuation and Outcomes in Patients With Heart Failure With Reduced Ejection Fraction – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Stopping digoxin after a heart failure exacerbation associated with risk of readmission – ACP Hospitalist (free) AND Digoxin Swings Toward Benefit in HFrEF, But Lack of Clarity Remains – Medscape (free registration required)


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Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Psychological Consequences of Admission to the ICU: Helping Patients and Families (free for a limited period)

Author Interview: Do Flexible Family Visitation Hours Reduce Delirium in ICU Patients? – (free)


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How I manage intracranial hypertension – Critical Care (free)


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A Multicenter Trial of Vena Cava Filters in Severely Injured Patients – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Liberal IVC Filter Use Not Warranted in Severe Trauma Patients – TCTMD (free)


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Impact of Point-of-Care Ultrasound in the Emergency Department on Care Processes and Outcomes in Critically Ill Nontraumatic Patients – Critical Care Explorations (free) (via @f_g_zampieri)


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Miracle medical machine ECMO makes heroic rescues, but leaves patients in limbo – Kaiser Health News / USA Today (free)

“ECMO is not designed to be a destination, but a bridge to somewhere – recovery, transplantation or an implanted heart device. But when patients are too sick to reach those goals, ECMO can become a “bridge to nowhere,” leaving the patient in limbo…”


Use of Peripherally Inserted Central Catheters in Patients With Advanced Chronic Kidney Disease: A Prospective Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Peripherally inserted central catheters often used in CKD – HealthDay (free) AND Too Many CKD Patients Get Central Catheters Despite Warnings – Medscape (free registration required)


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Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Setting Positive End-Expiratory Pressure in Mechanically Ventilated Patients Undergoing Surgery (free)


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Diabetic ketoacidosis and hyperosmolar hyperglycemic syndrome: review of acute decompensated diabetes in adult patients – The BMJ (free for a limited period)


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Commentary: Nebulized TXA for Hemoptysis

28 May, 2019 | 10:31h | UTC