Chest Medicine

Effect of Thoracoscopic Talc Poudrage vs Talc Slurry via Chest Tube on Pleurodesis Failure Rate Among Patients With Malignant Pleural Effusions: A Randomized Clinical Trial – JAMA (free for a limited period)

 

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Podcast: Update in Sleep Medicine

27 Nov, 2019 | 08:08h | UTC

Results of the Fontan Udenafil Exercise Longitudinal (FUEL) Trial – Circulation (free for a limited period)

Commentaries: Teens with Heart Disease Improve Exercise Capacity in Large Clinical Trial – Children’s Hospital of Philadelphia (free) AND Pediatric drug trial finds benefit in teens with heart defect – NIH News Releases (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Elexacaftor–Tezacaftor–Ivacaftor for Cystic Fibrosis with a Single Phe508del Allele – New England Journal of Medicine (link to abstract – $ for full-text)

Editorial: Realizing the Dream of Molecularly Targeted Therapies for Cystic Fibrosis (free)

Related Research: Efficacy and safety of the elexacaftor plus tezacaftor plus ivacaftor combination regimen in people with cystic fibrosis homozygous for the F508del mutation: a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)

Commentary: Three-drug combo improves lung function in most common genetic form of cystic fibrosis – UT Southwestern Medical Center (free)

 

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Long-term survival and cause-specific mortality of patients newly diagnosed with tuberculosis in São Paulo state, Brazil, 2010–15: a population-based, longitudinal study – The Lancet Infectious Diseases (free) (via @otavio_ranzani see Tweet)

Invited Commentary: Tuberculosis: an instrument of early mortality in life course (free)

 

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Is Mycobacterium tuberculosis infection life long? – The BMJ (free)

Commentaries: Tuberculous infection is not life-long in most people – University of Pennsylvania School of Medicine (free) AND In the absence of a true test for latent TB we need shorter, safer preventive treatments – The BMJ Opinion (free)

 

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Update on Oral Appliance Therapy

23 Oct, 2019 | 07:21h | UTC

Podcast: Tuberculosis Updates

22 Oct, 2019 | 08:05h | UTC

Update on Management of Stable COPD

22 Oct, 2019 | 08:01h | UTC

Metoprolol for the Prevention of Acute Exacerbations of COPD – New England Journal of Medicine (link to abstract – $ for full-text)

 

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Review: Ultrasonography of the Lung

10 Oct, 2019 | 09:07h | UTC

Supplement: Obstructive Sleep Apnea

4 Oct, 2019 | 07:54h | UTC

Effect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone on Reintubation Among Patients at High Risk of Extubation Failure: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Added Benefit of Noninvasive Ventilation to High-Flow Nasal Oxygen to Prevent Reintubation in Higher-Risk Patients (free for a limited period)

 

 


Pathology of Vaping-Associated Lung Injury – New England Journal of Medicine (free)

Commentaries: Vaping-related lung injuries resemble chemical burns, study finds – STAT (free) AND U.S. doctors rule out pneumonia due to inhaled oil as cause of vaping injuries – Reuters (free) AND Lung Damage From Vaping Resembles Chemical Burns, Report Says – The New York Times (10 articles per month are free)

Related: CDC Report: 76.9% of Patients with Vaping-related Lung Illnesses Used a THC-Containing Product (free) AND Preliminary Report: Pulmonary Illness Related to E-Cigarette Use (free)

 

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What are the respiratory effects of e-cigarettes? – The BMJ (free for a limited period)

 

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Nivolumab plus Ipilimumab in Advanced Non–Small-Cell Lung Cancer – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Two immunotherapy drug combination offers chemotherapy-free option for advanced NSCLC – European Society for Medical Oncology (free) AND Nivolumab/Low-dose Ipilimumab: A Potential Chemotherapy-Sparing Option in Advanced NSCLC – Pharmacy Times (free)

#ESMO19 – Just presented at the European Society of Medical Oncology Congress 2019 in Barcelona

 

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Protocolised non-invasive compared with invasive weaning from mechanical ventilation for adults in intensive care – Health Technology Assessment (free)

Source: Critical Care Reviews Newsletter

“A protocolized non-invasive weaning strategy did not reduce time to liberation from ventilation. However, patients who underwent non-invasive weaning had fewer days requiring IMV and required fewer antibiotics for respiratory infections.”

 


Nicotine patches used in combination with e-cigarettes (with and without nicotine) for smoking cessation: a pragmatic, randomised trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

Commentary: Quick Take: Nicotine patches used in combination with e-cigarettes (with and without nicotine) for smoking cessation – 2 Minute Medicine (free)

Related: It’s safest to avoid e-cigarettes altogether – unless vaping is helping you quit smoking – The Conversation (free)

 

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NICE Guideline: Tuberculosis

13 Sep, 2019 | 08:27h | UTC

Long-term macrolide antibiotics for the treatment of bronchiectasis in adults: an individual participant data meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

 

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The efficacy and safety of inhaled antibiotics for the treatment of bronchiectasis in adults: a systematic review and meta-analysis – The Lancet Respiratory Medicine (link to abstract – $ for full-text)

 

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Long term risk of symptomatic recurrent venous thromboembolism after discontinuation of anticoagulant treatment for first unprovoked venous thromboembolism event: systematic review and meta-analysis – The BMJ (free)

Commentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)

“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”

 

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Review: Diaphragmatic Dysfunction

14 Jul, 2019 | 19:45h | UTC

GINA 2019: a fundamental change in asthma management – European Respiratory Journal (free)

Original Guideline: 2019 GINA Report, Global Strategy for Asthma Management and Prevention (free PDF)

Related Studies: #ATS2019 – Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma (link to abstract and commentaries) AND Randomized Controlled Trials: Treatments for Mild Asthma Compared (link to abstract and commentaries)

“GINA no longer recommends treating adults/adolescents with asthma with short-acting bronchodilators alone. Instead, they should receive symptom-driven (in mild asthma) or a daily corticosteroid-containing inhaler, to reduce risk of severe exacerbations.”

 


Miracle medical machine ECMO makes heroic rescues, but leaves patients in limbo – Kaiser Health News / USA Today (free)

“ECMO is not designed to be a destination, but a bridge to somewhere – recovery, transplantation or an implanted heart device. But when patients are too sick to reach those goals, ECMO can become a “bridge to nowhere,” leaving the patient in limbo…”

 


Effect of Intraoperative High Positive End-Expiratory Pressure (PEEP) With Recruitment Maneuvers vs Low PEEP on Postoperative Pulmonary Complications in Obese Patients: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Setting Positive End-Expiratory Pressure in Mechanically Ventilated Patients Undergoing Surgery (free)

 

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