Chest Medicine

A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy – New England Journal of Medicine (link to abstract – $ for full-text)

Editorial: The Dangerous Flavors of E-Cigarettes (free)

Commentaries: E-cigarettes more effective than nicotine replacement therapies, finds major trial – Queen Mary University of London (free) AND UK study shows e-cigarettes help adult smokers quit, but US experts urge caution – CNN (free) AND E-Cigarettes Are Effective at Helping Smokers Quit, a Study Says – The New York times (10 articles per month are free) AND E-cigarettes ‘much better for quitting smoking’ – BBC (free) AND Study Found Vaping Beat Traditional Smoking-Cessation Options – NPR (free)


Related Commentary on Twitter

Automated Triaging of Adult Chest Radiographs with Deep Artificial Neural Networks – Radiology (free for a limited period)

Commentary: AI interprets chest x-rays, prioritizes critical findings – Radiology Business (free)


Related Commentary on Twitter


Temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: FAST – Health Technology Assessment (free)


Related Commentary on Twitter


Comparison of Nicotine and Toxicant Exposure in Users of Electronic Cigarettes and Combustible Cigarettes – JAMA Network Open (free)

Commentaries: Will the Debate Over e-Cigarettes Start Cooling Down? – JAMA Network Open (free) AND E-cigarettes less toxic to users than cigarettes, study says – CNN (free)


Related Commentary on Twitter


Review: Diaphragmatic Dysfunction

7 Dec, 2018 | 02:12h | UTC

Review: Confounders of Severe Asthma

5 Dec, 2018 | 00:01h | UTC

Review: Lung Scintigraphy in COPD

25 Nov, 2018 | 20:28h | UTC

The Global Burden of Tuberculosis Study

23 Nov, 2018 | 00:23h | UTC

Review: Silicosis and Lung Cancer

22 Nov, 2018 | 21:34h | UTC

Prednisone for the Prevention of Paradoxical Tuberculosis-Associated IRIS – New England Journal of Medicine (free)

“Prednisone treatment during the first 4 weeks after the initiation of ART for HIV infection resulted in a lower incidence of tuberculosis-associated immune reconstitution inflammatory syndrome than placebo, without evidence of an increased risk of severe infections or cancers.”


Prophylactic antibiotic therapy for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)

Summary: Preventative antibiotic therapy for people with COPD – Cochrane Library (free)

“Use of continuous and intermittent prophylactic antibiotics results in a clinically significant benefit in reducing exacerbations in COPD patients.”


Effect of a Low vs Intermediate Tidal Volume Strategy on Ventilator-Free Days in Intensive Care Unit Patients Without ARDS: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Lessons From ARDS for Non-ARDS Research: Remembrance of Trials Past (free)

“Among patients in the ICU receiving invasive ventilation, a strategy with low tidal volume was not more effective than a strategy using intermediate tidal volume.”


Effect of Protocolized Weaning with Early Extubation to Noninvasive Ventilation vs Invasive Weaning on Time to Liberation From Mechanical Ventilation Among Patients With Respiratory Failure: The Breathe Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Weaning From Mechanical Ventilation: What Should Be Done When a Patient’s Spontaneous Breathing Trial Fails? (free for a limited period)

“Among patients requiring mechanical ventilation in whom a spontaneous breathing trial had failed, early extubation to noninvasive ventilation did not shorten time to liberation from any ventilation.”


NCCN Guideline: Small Cell Lung Cancer

17 Oct, 2018 | 13:42h | UTC

Review: Cardiovascular Disease and COPD

11 Oct, 2018 | 20:08h | UTC

Review: Pulmonary Vasculitis

5 Oct, 2018 | 01:41h | UTC

Global Tuberculosis Report 2018

21 Sep, 2018 | 01:44h | UTC

Did Juul Lure Teenagers and Get ‘Customers for Life’? – The New York Times (10 articles per month are free)

“…will it be possible to get people who are addicted to cigarettes to switch to e-cigarettes, which are less harmful, without enticing a new generation or non-smokers to try them?” (via @CaulfieldTim see Tweet)


Review: Idiopathic Pulmonary Fibrosis

2 Sep, 2018 | 02:19h | UTC

Antibiotics for prolonged wet cough in children – Cochrane Library (link to abstract and plain language summary – $ for full-text)

Commentary: Antibiotics for pediatric chronic wet cough: Cochrane review – Univadis (free registration required)


Study: Asthma and COPD Overlap in Women

23 Aug, 2018 | 23:42h | UTC

Report: E-Cigarettes

23 Aug, 2018 | 22:33h | UTC

Association Between Electronic Cigarette Use and Myocardial Infarction – American Journal of Preventive Medicine (free for a limited period)

Commentary: Risk of heart attacks is double for daily e-cigarette users – University of California – San Francisco, via ScienceDaily (free)

“New analysis shows five-fold risk for people who use both cigarettes and e-cigarettes daily” (from ScienceDaily)


Antibiotics should be restricted for COPD – National Institute for Health and Care Excellence (free)

Commentaries: Antibiotics should be restricted for COPD, says NICE – OnMedica (free) AND UK officials recommend limits on antibiotics for COPD – CIDRAP (free)

“The draft antimicrobial guidance recommends that antibiotics should be offered to people who have a severe flare up of symptoms, also known as a severe acute exacerbation”


Review: COPD and Air Travel

22 Jun, 2018 | 02:07h | UTC

IOTA – Liberal vs Conservative Oxygen Therapy in the Critically Ill – The Bottom Line (free)

Original Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)

“Hyperoxia is BAD –> Aim for lowest safest inspired O2 in critically ill pts & titrate FiO2 down if SpO2 >95%” (via @srrezaie see Tweet)


E-cigarettes, Juuls and Heat-Not-Burn Devices: The Science and Regulation of Vaping – Hopkins Bloomberg Public Health Magazine (free)

E-cigarettes can help some people quit smoking but may entice others to start. So how should they be regulated?


World No Tobacco Day, 31 May 2018

1 Jun, 2018 | 03:15h | UTC

Randomized Trial: ECMO for Severe ARDS

29 May, 2018 | 20:16h | UTC

Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome – New England Journal of Medicine (link to abstract – $ for full-text)

See also: NEJM Tweet with visual abstract

Commentary: Extracorporeal Membrane Oxygenation for Severe Acute Respiratory Distress Syndrome – The Bottom Line (free)

“There is something very disturbing about a trial with HR=0.76, 95% CI 0.55-1.04 for the primary endpoint being stopped early for futility”. This TWEETORIAL by @ADAlthousePhD is a huge help in interpreting the results of this important trial (see more on the rise of “Tweetorial” here).


Review: Acute Lung Injury

29 May, 2018 | 18:41h | UTC