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Cardiology (all articles)

2023 ESH Guidelines for the management of arterial hypertension

3 Jul, 2023 | 14:34h | UTC

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the European Renal Association (ERA) and the International Society of Hypertension (ISH) – Journal of Hypertension

 

M-A | Higher versus lower blood pressure targets after cardiac arrest

3 Jul, 2023 | 14:18h | UTC

Higher versus lower blood pressure targets after cardiac arrest: Systematic review with individual patient data meta-analysis – Resuscitation

 

AHA Scientific Statement | Considerations on the management of acute postoperative ischemia after cardiac surgery

29 Jun, 2023 | 14:07h | UTC

Considerations on the Management of Acute Postoperative Ischemia After Cardiac Surgery: A Scientific Statement From the American Heart Association – Circulation

 

Post hoc analysis | Low-dose aspirin linked to increased risk of anemia in older adults

29 Jun, 2023 | 14:06h | UTC

Summary: In a post hoc analysis of the ASPREE randomized controlled trial, the impact of daily low-dose aspirin on anemia, hemoglobin, and serum ferritin concentrations in elderly individuals was investigated. The study included 19,114 community-dwelling individuals aged 70 years and older (or ≥65 years for Black and Hispanic individuals) from Australia and the United States.

Findings reveal an increased incidence of anemia in the aspirin group compared to the placebo group (51.2 events versus 42.9 events per 1000 person-years, respectively). This correlates to a 20% increase in risk (hazard ratio, 1.20 [95% CI, 1.12 to 1.29]). Hemoglobin concentrations displayed a more pronounced decline in the aspirin group by 0.6 g/L per 5 years. Additionally, among participants with ferritin measures, the aspirin group exhibited a greater prevalence of ferritin levels less than 45 µg/L at year 3 and overall decline in ferritin by 11.5%. The study found similar results even in the absence of major bleeding.

This research underscores the risk of anemia and decline in ferritin in otherwise healthy older adults taking low-dose aspirin, highlighting the need for periodic monitoring of hemoglobin levels. However, the study lacked data on the causes of anemia, indicating the need for further research.

Article: Effect of Low-Dose Aspirin Versus Placebo on Incidence of Anemia in the Elderly: A Secondary Analysis of the Aspirin in Reducing Events in the Elderly Trial – Annals of Internal Medicine (link to abstract – $ for full-text)

News Release: Low-dose aspirin may increase anaemia risk in healthy older adults: study – Monash University

Commentaries:

Aspirin Use Ups Risk of Anemia in Elderly Patients: ASPREE – TCTMD

Low-dose aspirin associated with 20% increase in risk of anemia among older adults – ACP Internist

Original Study: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly – New England Journal of Medicine

 

Review | Silent cerebral lesions following catheter ablation for atrial fibrillation

29 Jun, 2023 | 13:51h | UTC

Silent cerebral lesions following catheter ablation for atrial fibrillation: a state-of-the-art review – EP Europace

 

Commentary on Twitter

 

Podcast | Antiplatelets, anticoagulation for coronary artery disease and atrial fibrillation

28 Jun, 2023 | 13:11h | UTC

#400 Antiplatelets, Anticoagulation for Coronary Artery Disease and Afib – The Curbsiders

 

Review | Management of short-term mechanical circulatory support for cardiogenic shock in adults in the intensive cardiac care unit

27 Jun, 2023 | 13:42h | UTC

Step by step daily management of short-term mechanical circulatory support for cardiogenic shock in adults in the intensive cardiac care unit: a clinical consensus statement of the Association for Acute CardioVascular Care of the European Society of Cardiology SC, the European Society of Intensive Care Medicine, the European branch of the Extracorporeal Life Support Organization, and the European Association for Cardio-Thoracic Surgery – European Heart Journal. Acute Cardiovascular Care

 

Review | Hypertension management in patients with cardiovascular comorbidities

27 Jun, 2023 | 13:39h | UTC

Hypertension management in patients with cardiovascular comorbidities – European Heart Journal

 

Commentary on Twitter

 

Review | Functional coronary angiography for the assessment of the epicardial vessels and the microcirculation

27 Jun, 2023 | 13:33h | UTC

Functional coronary angiography for the assessment of the epicardial vessels and the microcirculation – EuroIntervention

 

Commentary on Twitter

 

Secondary analysis of a RCT | Bempedoic acid reduces CV events in statin-intolerant patients with high CV risk

26 Jun, 2023 | 00:49h | UTC

Summary: This secondary analysis of a Randomized Clinical Trial (RCT) evaluated the efficacy of bempedoic acid in primary prevention of cardiovascular events among statin-intolerant patients at high cardiovascular risk. From a total of 13,970 participants, 4206 met the criteria for primary prevention and were analyzed in this study. Those allocated to receive bempedoic acid showed a significant reduction in major cardiovascular events, reflected in a hazard ratio of 0.70.

The average age of this patient cohort was 68 years, and most participants (66%) were diagnosed with diabetes. Treatment with bempedoic acid also led to a significant 21.3% reduction in low-density lipoprotein cholesterol (LDL-C) levels and a 21.5% decrease in high-sensitivity C-reactive protein levels, suggesting improved cardiovascular health.

This study underscores the potential benefits of lipid-modulating therapy for primary prevention in high-risk patients, who are often undertreated. However, it is important to note the inherent limitations of this secondary analysis. The analysis was performed on a subgroup within a larger clinical trial, which could potentially lead to false-positive findings due to multiple testing. Furthermore, the results may not generalize to younger populations, those with lower pretreatment LDL-C levels, those without diabetes, or those with a lower baseline cardiovascular risk.

Article: Bempedoic Acid for Primary Prevention of Cardiovascular Events in Statin-Intolerant Patients – JAMA (free for a limited period)

Editorial: Bempedoic Acid for High-Risk Primary Prevention of Cardiovascular Disease: Not a Statin Substitute but a Good Plan B – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Study Suggests Bempedoic Acid Could Find Role in Primary Prevention – HCP Live

Original Study: RCT | Bempedoic acid shows modest reduction in cardiovascular events for statin-intolerant patients

 

RCT | Shortened head-up tilt test is non-inferior to traditional method for suspected vasovagal syncope

26 Jun, 2023 | 00:42h | UTC

Summary: The randomized clinical trial compared a short-duration head-up tilt test (HUTT) with the traditional longer-duration test for diagnosing suspected vasovagal syncope (VVS). The study involved 554 patients, half of which underwent the Fast protocol and the other half the Traditional protocol. The Fast protocol consisted of a 10-minute passive phase followed by a 10-minute nitroglycerin (NTG) phase if the passive phase yielded negative results, while the Traditional protocol included a 20-minute passive phase and a 15-minute NTG phase.

The findings showed no significant difference in the diagnostic value between the two protocols. Positive responses, identified by syncope induction amid hypotension or bradycardia, were seen in 60.3% of patients in the Fast protocol and 58.5% in the Traditional. However, there was a trend of less vasodepressor response in the Fast protocol during the passive phase.

This study suggests that the Fast HUTT protocol could replace the Traditional one, reducing test duration from 40 to 25 minutes without compromising diagnostic efficacy. However, the research didn’t assess the specificity of the Fast HUTT protocol in patients without a history of syncope, which serves as a limitation.

Article: Short-duration head-up tilt test potentiated with sublingual nitroglycerin in suspected vasovagal syncope: the fast Italian protocol – European Heart Journal (free for a limited period)

 

Commentary on Twitter

 

Review | How to treat diffuse large B-cell lymphoma: oncologic and cardiovascular considerations

26 Jun, 2023 | 00:33h | UTC

How to Treat Diffuse Large B-Cell Lymphoma: Oncologic and Cardiovascular Considerations – JACC: CardioOncology

 

Commentary on Twitter

 

Cohort Study | Risk and outcome of infective endocarditis in streptococcal bloodstream infections according to streptococcal species

22 Jun, 2023 | 15:09h | UTC

Risk and Outcome of Infective Endocarditis in Streptococcal Bloodstream Infections according to Streptococcal Species – Clinical Microbiology

 

Review | Early lead extraction for infected implanted cardiac electronic devices

22 Jun, 2023 | 15:03h | UTC

Early Lead Extraction for Infected Implanted Cardiac Electronic Devices: JACC Review Topic of the Week – Journal of the American College of Cardiology

 

SCORE2-Diabetes | 10-year cardiovascular risk estimation in type 2 diabetes in Europe

22 Jun, 2023 | 14:57h | UTC

SCORE2-Diabetes: 10-year cardiovascular risk estimation in type 2 diabetes in Europe – European Heart Journal

Commentary: SCORE2- diabetes prediction model estimates the 10 year risk of cardiovascular disease in individuals with type 2 diabetes – News Medical

 

Commentary on Twitter

 

Acute heart failure: differential diagnosis and treatment

21 Jun, 2023 | 13:37h | UTC

Acute heart failure: differential diagnosis and treatment – European Heart Journal Supplements

Related: Acute Heart Failure: Diagnostic–Therapeutic Pathways and Preventive Strategies—A Real-World Clinician’s Guide – Journal of Clinical Medicine

 

Consensus Statement | Anatomy, imaging, and nomenclature of congenital aortic root malformations

21 Jun, 2023 | 13:25h | UTC

Expert Consensus Statement: Anatomy, Imaging, and Nomenclature of Congenital Aortic Root Malformations – Cardiology in the Young

 

Position statement | Gastrointestinal bleeding and endoscopic procedures in patients on antiplatelet and/or anticoagulant therapy

21 Jun, 2023 | 13:22h | UTC

Position statement from the Indian Society of Gastroenterology, Cardiological Society of India, Indian Academy of Neurology and Vascular Society of India on gastrointestinal bleeding and endoscopic procedures in patients on antiplatelet and/or anticoagulant therapy – Indian Journal of Gastroenterology (if the link is paywalled, try this one)

 

RCT | No superior recovery with minithoracotomy over sternotomy in mitral valve repair

20 Jun, 2023 | 12:51h | UTC

Minithoracotomy vs Conventional Sternotomy for Mitral Valve Repair: A Randomized Clinical Trial – JAMA (free for a limited period)

See also: Visual Abstract

Commentary: Mitral valve repair: How a minimally invasive approach compares to conventional surgery – Cardiovascular Business

 

Cohort Study | Five-year safety and efficacy of leadless pacemakers

20 Jun, 2023 | 12:40h | UTC

Five-year safety and efficacy of leadless pacemakers in a Dutch cohort – Heart Rhythm

 

RCT | Testosterone replacement does not appear to increase cardiovascular events in hypogonadal men at high risk

19 Jun, 2023 | 14:13h | UTC

Cardiovascular Safety of Testosterone-Replacement Therapy – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Cleveland Clinic-Led Trial Finds Testosterone-Replacement Therapy Does Not Increase Incidence of Major Adverse Cardiac Events for Men with Low Testosterone – Cleveland Clinic

 

Commentary on Twitter

 

Review | Role of GLP1 receptor agonists in achieving weight loss and improving CV outcomes in people with overweight and obesity

19 Jun, 2023 | 13:40h | UTC

Role of Glucagon‐Like Peptide‐1 Receptor Agonists in Achieving Weight Loss and Improving Cardiovascular Outcomes in People With Overweight and Obesity – Journal of the American Heart Association

 

RCT | Mild hypercapnia after cardiac arrest shows no improvement in neurological outcomes vs. normocapnia

16 Jun, 2023 | 14:15h | UTC

Mild Hypercapnia or Normocapnia after Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: New data supports current management of CO2 levels in cardiac arrest patients – UCD Dublin

 

Perspective | Benefits and pitfalls of social media in cardiology

16 Jun, 2023 | 14:13h | UTC

Impact of Social Media and Multimedia Platforms: View From the JACC: Case Reports SoMe Editors – JACC: Case Reports

 

Commentary on Twitter

 

Brief Review | Why is cuff size so important and other factors that affect accurate blood pressure measurement

16 Jun, 2023 | 14:12h | UTC

Why Is Cuff Size So Important and Other Factors That Affect Accurate Blood Pressure Measurement – American College of Cardiology

 

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