Cardiology

Latest Updates on Lipid Management

21 Apr, 2019 | 21:14h | UTC

Assessment of the Role of Niacin in Managing Cardiovascular Disease Outcomes: A Systematic Review and Meta-analysis – JAMA Network Open (free)

Commentaries: Evidence Supporting Niacin Use for Cardiovascular Disease Prevention Evaluated – MPR (free) AND Niacin: Time to Revisit That FDA Indication – MedPage Today (free registration required)

 

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Effect of an Incentive Spirometer Patient Reminder After Coronary Artery Bypass Grafting: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)

Invited Commentary: Benefits of Incentive Spirometry: Still More Work to Do – JAMA Surgery (free)

Simple intervention leading to improved outcomes, but confirmatory studies are required (see invited commentary).

 


Effect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease: The CHAT Randomized Clinical Trial – Circulation: Cardiovascular Quality and Outcomes (free)

Editorial: The CHAT Trial:Time for a Heart to Heart Talk (free)

Very important negative study.

 

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Review: Cardiogenic Shock

8 Apr, 2019 | 01:06h | UTC

Sham-Controlled Randomized Trials of Catheter-Based Renal Denervation in Patients With Hypertension – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Catheter-Based Renal Sympathetic Denervation Effectively Lowers BP – Cardiology Advisor (free) AND Renal Denervation Lowers BP in Sham-Controlled Studies: Meta-Analysis – TCTMD (free)

Compared with sham control, renal denervation lowered 24-h ambulatory systolic blood pressure by 3.65 mm Hg and diastolic blood pressure by 1.71 mm Hg.

 


In-Hospital Cardiac Arrest: A Review

28 Mar, 2019 | 07:31h | UTC

In-Hospital Cardiac Arrest: A Review – JAMA (free for a limited period)

 


Joint association of urinary sodium and potassium excretion with cardiovascular events and mortality: prospective cohort study – The BMJ (free)

 

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Schedules for Self-monitoring Blood Pressure: A Systematic Review – American Journal of Hypertension (free)

Home blood pressure should be measured for 3 days, increased to 7 only when mean blood pressure is close to a diagnostic or treatment threshold.”

 


Vitamin K for reversal of excessive vitamin K antagonist anticoagulation: a systematic review and meta-analysis – Blood Advances (free)

Our findings indicate that patients on VKA therapy who have an INR between 4.5 and 10.0 without bleeding are not likely to benefit from vitamin K administration in addition to temporary VKA cessation.”

 


Diagnostic Accuracy of Point-of-Care Lung Ultrasonography and Chest Radiography in Adults With Symptoms Suggestive of Acute Decompensated Heart Failure: A Systematic Review and Meta-analysis – JAMA Network Open (free)

“The findings suggest that Lung Ultrasonography is more sensitive than Chest Radiography in detecting pulmonary edema in ADHF”.

 


Presented at the American College of Cardiology (ACC) 2019 Scientific Session.

Coronary Angiography after Cardiac Arrest without ST-Segment Elevation – New England Journal of Medicine (free for a limited period)

Editorial: Coronary Angiography after Cardiac Arrest — The Right Timing or the Right Patients? (free for a limited period)

Commentaries: Angiography timing does not impact survival after cardiac arrest for NSTEMI patients – American College of Cardiology (free) AND COACT: Delayed Angiography Does Not Compromise Survival in Cardiac Arrest Patients Without STEMI – TCTMD (free)

 

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Presented at the European Heart Rhythm Association 2019 Congress.

Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation – New England Journal of Medicine (free for a limited period)

Editorial: The RACE to Treat Atrial Fibrillation in the Emergency Department (free for a limited period)

Commentary: For Acute A-fib, Wait-and-See Approach May Spare Many Patients from Cardioversion – TCTMD (free)

 

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Presented at the American College of Cardiology (ACC) 2019 Scientific Session.

Effect of Catheter Ablation vs Antiarrhythmic Drug Therapy on Mortality, Stroke, Bleeding, and Cardiac Arrest Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial – JAMA (free for a limited period)

Related Study: Effect of Catheter Ablation vs Medical Therapy on Quality of Life Among Patients With Atrial Fibrillation: The CABANA Randomized Clinical Trial – JAMA (free for a limited period)

Video Summary: Catheter Ablation vs Drug Therapy for Patients With Atrial Fibrillation: The CABANA Trial (free)

Editorial: Catheter Ablation for Atrial Fibrillation: Lessons Learned From CABANA (free for a limited period)

Commentary: Surgery no better than medication at preventing serious complications of atrial fibrillation – NIH News Releases (free)

 

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Presented at the American College of Cardiology (ACC) 2019 Scientific Session.

Transcatheter Aortic-Valve Replacement with a Self-Expanding Valve in Low-Risk Patients – New England Journal of Medicine (free for a limited period)

Commentary: In study, TAVR is superior to surgery for low-risk patients with aortic valve stenosis – Columbia University Irving Medical Center (free)

“”The main limitation of the study is that the current results reflect outcomes after one year, which isn’t long enough to assess the long-term durability of the replacement valve,” said Leon. “Patients in the study will be followed for at least 10 years so that we can measure their long-term outcomes and inform the medical community.” (from Columbia University)

 


Associations of Dietary Cholesterol or Egg Consumption With Incident Cardiovascular Disease and Mortality – JAMA (free for a limited period)

Commentaries: Are Eggs Good Or Bad? How You Should Interpret This Latest Study – Forbes (free) AND Are eggs good or bad for you? New research rekindles the debate – STAT (free) AND Eggs are bad – then good – then bad again? What gives? – Diet Doctor (free)

 

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Evidence evolving on aspirin as prevention – ACP Internist (free)

Related: Randomized Trial: Aspirin for Primary Prevention of Cardiovascular Disease (link to abstract and commentaries) AND Randomized Trial: Effects of Aspirin for Primary Prevention in Persons with Diabetes (link to abstract and commentaries) AND Randomized Trial: Effect of Aspirin on All-Cause Mortality in the Healthy Elderly (link to abstract and commentaries) AND Meta-Analysis: Association of Aspirin Use for Primary Prevention with Cardiovascular Events and Bleeding Events (link to abstract and commentaries)

“In patients who have not had a prior cardiovascular event, aspirin’s protective effects are modest and may not necessarily outweigh its potential downsides (namely, risk of bleeding and hemorrhagic stroke).”

 


Higher versus lower doses of ACE inhibitors, angiotensin-2 receptor blockers and beta-blockers in heart failure with reduced ejection fraction: Systematic review and meta-analysis – PLOS One (free)

 

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Long-Term Risk of Heart Failure in Breast Cancer Patients After Adjuvant Chemotherapy With or Without Trastuzumab – JACC: Heart Failure (link to abstract – $ for full-text) (via @md_arianemacedo)

Commentary: Long-Term Risk of Heart Failure After Chemotherapy With Trastuzumab – American College of Cardiology (free)

“Trastuzumab treatment is associated with a 2-fold increased risk of late HF compared with chemotherapy treatment alone.”

 


Management of Cardiovascular Disease in Women With Breast Cancer – Circulation (free)

Related: AHA Scientific Statement on Cardio-Oncology (several guidelines on the subject)

 

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A Review of the Role of Breast Arterial Calcification for Cardiovascular Risk Stratification in Women – Circulation (free)

Commentary: Breast Calcifications May Hold Important Clues for CV Risk Stratification – TCTMD (free)

 

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Dual Antiplatelet Therapy Duration Based on Ischemic and Bleeding Risks After Coronary Stenting – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: PRECISE-DAPT Score and Complex PCI – American College of Cardiology (free) AND After Stenting, Long-Term DAPT Benefits Those at Low Bleeding Risk More – NEJM Journal Watch (free)

Related Guidelines: 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy (free) AND 2017 European Society of Cardiology focused update on dual antiplatelet therapy in coronary artery disease (free) AND 2016 ACC/AHA Guideline Focused Update on Duration of Dual Antiplatelet Therapy in Patients With Coronary Artery Disease(free)

“Prospective studies are needed to verify whether patients at high bleeding risk derive net benefit from a shorter duration of DAPT after stenting, regardless of procedural complexity.” (from American College of Cardiology)

 

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Cardiovascular Risk Factors Associated with Venous Thromboembolism – JAMA Cardiology (free)

“Older age, smoking, and adiposity were consistently associated with higher VTE risk.”

 


Comparing Automated Office Blood Pressure Readings With Other Methods of Blood Pressure Measurement for Identifying Patients With Possible Hypertension: A Systematic Review and Meta-analysis – JAMA Internal Medicine (link to abstract – $ for full-text)

Commentaries: Automated BP Readings More Accurate Than Manual Measurements – NEJM Journal Watch (free) AND Automated office BP readings best routine measures – MDedge Cardiology (free)

 

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Worldwide Dyslipidemia Guidelines

4 Feb, 2019 | 22:32h | UTC

Effect of Intensive vs Standard Blood Pressure Control on Probable Dementia: A Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Prevention of Cognitive Impairment With Intensive Systolic Blood Pressure Control (free for a limited period)

Commentaries: Does intensive blood pressure control reduce dementia? – NIH News Releases (free) AND Intensive BP Control Helps Prevent Mild Cognitive Impairment – NEJM Journal Watch (free)

 

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Mechanisms and diagnostic evaluation of persistent or recurrent angina following percutaneous coronary revascularization – European Heart Journal (free)

Summary: Angina After PCI – American College of Cardiology (free)

 

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Carbohydrate quality and human health: a series of systematic reviews and meta-analyses – The Lancet (link to abstract – $ for full-text)

Commentaries: High intake of dietary fiber and whole grains associated with reduced risk of non-communicable diseases – ScienceDaily (free) AND High-fiber diet linked to lower risk of death and chronic diseases – CNN (free) AND Expert reaction to series of systematic reviews and meta-analyses about dietary fibre and the risk of non-communicable disease – Science Media Centre (free)

 

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