Cardiology

The effect of remote ischaemic preconditioning on myocardial injury in emergency hip fracture surgery (PIXIE trial): phase II randomised clinical trial – The BMJ (free)

Related Perspective: Remote ischaemic preconditioning: an intervention for anaesthetists? – British Journal of Anaesthesia (free)

 

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Review: Cardiomyopathy and Pregnancy

27 Nov, 2019 | 07:39h | UTC

A Comparison of Two LDL Cholesterol Targets after Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Treat Stroke to Target Finds Lower Risk of CV Events With Lower LDL-C Levels – American College of Cardiology (free) AND Treat Stroke to Target – Treat Stroke to Target – American College of Cardiology (free) AND Lower Cholesterol Cuts CV Events: Treat Stroke to Target Trial – TCTMD (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Results of the Fontan Udenafil Exercise Longitudinal (FUEL) Trial – Circulation (free for a limited period)

Commentaries: Teens with Heart Disease Improve Exercise Capacity in Large Clinical Trial – Children’s Hospital of Philadelphia (free) AND Pediatric drug trial finds benefit in teens with heart defect – NIH News Releases (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Coronary Microvascular Dysfunction Causing Cardiac Ischemia in Women – JAMA (free for a limited period)

Related: Prognosis and Predictors of Mortality in Patients Suffering Myocardial Infarction With Non‐Obstructive Coronary Arteries (study, guidelines, and reviews on the subject)

 

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Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Colchicine Cardiovascular Outcomes Trial – COLCOT – American College of Cardiology (free) AND COLCOT Renews Hope for Anti-inflammatory in Secondary Prevention: Colchicine – TCTMD (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Early Surgery or Conservative Care for Asymptomatic Aortic Stenosis – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: RECOVERY Finds Early Surgery Beneficial For Asymptomatic Severe AS Patients – American College of Cardiology (free) AND Randomized Comparison of Early Surgery Versus Conventional Treatment in Very Severe Aortic Stenosis – RECOVERY – American College of Cardiology (free) AND Early Surgery Beats a Conservative Approach in Asymptomatic AS: RECOVERY – TCTMD (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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A Controlled Trial of Rivaroxaban after Transcatheter Aortic-Valve Replacement – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: GALILEO Trial Finds Higher Risk of Death, Bleeding With Rivaroxaban After TAVR – American College of Cardiology (free) AND Global Study Comparing a Rivaroxaban-based Antithrombotic Strategy to an Antiplatelet-based Strategy After TAVR – GALILEO – American College of Cardiology (free) AND GALILEO: Rivaroxaban-Based Antithrombotic Strategy or Antiplatelet-Based Strategy After TAVR? – Docwire (free)

#AHA19 – Just Presented at the 2019 American Heart Association Annual Meeting

 

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Large-Scale Assessment of a Smartwatch to Identify Atrial Fibrillation – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: What Can We Learn From The Apple Heart Study? – Cardiobrief (free)

“…nearly half a million people were required to identify a few hundred people with AF. (It should further be noted that we have no idea whether the patients identified in this group will even benefit from their diagnosis, since they may differ in important ways from AF patients identified by traditional means.)” (from Cardiobrief)

 


UPDATE: The FDA Warns that Biotin May Interfere with Lab Tests: FDA Safety Communication – U.S Food and Drug Administration (free)

Commentary: FDA Updates Warning on Biotin Interfering with Lab Results – NEJM Journal Watch (free)

“…the FDA is particularly concerned about biotin interference causing a falsely low result for troponin, a clinically important biomarker to aid in the diagnosis of heart attacks, which may lead to a missed diagnosis and potentially serious clinical implications. The FDA continues to receive adverse events reports indicating biotin interference caused falsely low troponin results.”

 


Risk of Mortality Following Catheter Ablation of Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Mortality Risk After Catheter Ablation of Atrial Fibrillation – American College of Cardiology (free) AND Early mortality ‘a very real complication’ after catheter ablation of AFib – Cardiovascular Business (free) AND Afib Ablation Deaths Do Happen – MedPage Today (free registration required)

 

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The Silent Heart Attack You Didn’t Know You Had – The New York Times (10 articles per month are free)

Related Studies: Silent Myocardial Infarction Often Precedes Sudden Cardiac Death (link to abstract and commentaries) AND Cohort Study: Long-term Outcomes of Unrecognized MI (link to abstract and commentaries)

 


Five-Year Outcomes after PCI or CABG for Left Main Coronary Disease – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: EXCEL at 5 Years: PCI for Left Main CAD Still Noninferior to CABG – TCTMD (free) AND EXCEL: No Significant Outcome Differences in PCI vs CABG for Left Main Coronary Disease at Five Years – American College of Cardiology (free)

Related Meta-Analysis: All-cause mortality and major cardiovascular outcomes comparing percutaneous coronary angioplasty versus coronary artery bypass grafting in the treatment of unprotected left main stenosis: a meta-analysis of short-term and long-term randomised trials – OpenHeart (free) AND Percutaneous Coronary Intervention vs Coronary Artery Bypass Grafting in Patients With Left Main Coronary Artery Stenosis: A Systematic Review and Meta-analysis – JAMA Cardiology (free) AND Percutaneous Coronary Intervention Using Drug-Eluting Stents Versus Coronary Artery Bypass Grafting for Unprotected Left Main Coronary Artery Stenosis: A Meta-Analysis of Randomized Trials – Circulation: Cardiovascular Interventions (free) AND Percutaneous intervention versus coronary artery bypass graft surgery in left main coronary artery stenosis: a systematic review and meta-analysis – BMC Medicine (free) AND Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data – The Lancet (link to abstract – $ for full-text)

 

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Efficacy of Neurohormonal Therapies in Preventing Cardiotoxicity in Patients With Cancer Undergoing Chemotherapy – JACC CardioOncology (free)

 

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Association of Treatment With Metformin vs Sulfonylurea With Major Adverse Cardiovascular Events Among Patients With Diabetes and Reduced Kidney Function – JAMA (free for a limited period)

Commentaries: Metformin Superior for Lowering CV Risk in Diabetics Who Progress to CKD – Renal & Urology News (free) AND Metformin Monotherapy Benefits Heart Even in Early CKD – MedPage Today (free registration required)

 

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Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Meta-Analysis of TAVR vs. SAVR in Low-Risk Patients – American College of Cardiology (free) AND TAVR Survival Surpasses SAVR in Low-Risk Patients: Meta-analysis – Medscape (free registration required)

“The one clear unknown that everyone points to is valve durability” (form Medscape)

“longer follow-up regarding valve degeneration will be needed to confirm TAVR as the preferred treatment for low-risk patients with severe AS.” (from American College of Cardiology)

 


How to diagnose heart failure with preserved ejection fraction: the HFA–PEFF diagnostic algorithm: a consensus recommendation from the Heart Failure Association (HFA) of the European Society of Cardiology (ESC) – European Heart Journal (free)

 

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The Task Force for the management of patients with supraventricular tachycardia of the European Society of Cardiology (ESC): Developed in collaboration with the Association for European Paediatric and Congenital Cardiology (AEPC) (free)

 

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Maximum-fixed energy shocks for cardioverting atrial fibrillation – European Heart Journal (free)

Commentary: Comparison of High vs. Escalating Shocks – CHESS – American College of Cardiology (free)

 

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Commentaries: Dapagliflozin in Patients With Heart Failure and Reduced Ejection Fraction – DAPA-HF – American College of Cardiology (free) Dapagliflozin reduces death and hospitalisation in patients with heart failure – European Society of Cardiology (free)

 

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Commentaries: HiSTORIC Trial Supports Single-Test Rule-Out of MI Using High-Sensitivity Troponin – TCTMD (free) AND Risk-Based Thresholds for hs-Troponin I Safely Speed MI Rule-Out – MedPage Today (free registration required) AND HISTORIC: Early Rule-Out Strategy Using High-Sensitivity Cardiac Troponin I Reduced Length of Stay, Hospital Readmissions in Suspected ACS Patients – American College of Cardiology (free)

Related Studies: Randomized Trial: High-Sensitivity Troponin in the Evaluation of Suspected Acute Coronary Syndrome (free study and commentaries) AND Cohort Study: The Introduction of High-sensitive Troponins Had No Impact on Survival (free study and commentaries)

 

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Angiotensin–Neprilysin Inhibition in Heart Failure with Preserved Ejection Fraction – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: PARAGON-HF: Sacubitril-Valsartan in HFpEF Patients Did Not Result in Significantly Lower Rates of Hospitalizations, Death – American College of Cardiology (free)

 

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Ticagrelor or Prasugrel in Patients with Acute Coronary Syndromes – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Prasugrel cuts ischaemic events in acute coronary syndrome patients – European Society of Cardiology (free) AND Prasugrel Bests Ticagrelor in ACS Patients Heading to PCI: ISAR-REACT 5 – TCTMD (free) AND Intracoronary Stenting and Antithrombotic Regimen 5 – ISAR-REACT 5 – American College of Cardiology (free)

 

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