Everolimus-Eluting Bioresorbable Scaffolds Versus Everolimus-Eluting Metallic Stents

23Jun
2017

Everolimus-Eluting Bioresorbable Scaffolds Versus Everolimus-Eluting Metallic Stents – Journal of the American College of Cardiology (free) (RT @JACCJournals see Tweet)

In this meta-analysis including 7 randomized trials bioresorbable vascular scaffolds were associated with both lower efficacy and higher thrombotic risk over time.

 

Trans-catheter aortic valve implantation

23Jun
2017

Targeted temperature management in the ICU

23Jun
2017

Women and Heart Disease: New Data Reaffirm Lack of Awareness By Women and Physicians

23Jun
2017

Time-to-Furosemide Treatment and Mortality in Acute Heart Failure

23Jun
2017

Time-to-Furosemide Treatment and Mortality in Patients Hospitalized With Acute Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: Door-to-Furosemide Time in Acute Heart Failure – American College of Cardiology, Latest in Cardiology (free)

“God help us if this sort of observational data leads to “door to furosemide time” being adopted as a quality measure” (RT @adamcifu see Tweet)

 

Guideline summary: Consensus on Surgical Treatment of Infective Endocarditis

23Jun
2017

Radiation Associated Cardiac Disease

23Jun
2017

Breastfeeding and the Risk of Maternal Cardiovascular Disease

23Jun
2017

Cardiopulmonary resuscitation – 30:2 or just keep going?

22Jun
2017

Cardiopulmonary resuscitation – 30:2 or just keep going? – by Scott Munro, in Evidently Cochrane (free) (RT @NIHR_DC see Tweet)

“Untrained bystander CPR had better outcomes when given telephone advice from EMS services to perform continuous CPR, rather than interrupted CPR with rescue breaths”. For trained EMS professionals, “it is possible that there is little or no difference between the two approaches”.

 

Is aircraft noise exposure associated with cardiovascular disease and hypertension?

22Jun
2017

Antiplatelet Therapy in Patients With Coronary Stents Undergoing Elective Noncardiac Surgery

20Jun
2017

Therapeutic Patient Education Interventions to Promote Cardiovascular Patient Self-Management

20Jun
2017

Takotsubo Cardiomyopathy may cause lasting damage

20Jun
2017

Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association

19Jun
2017

Dietary Fats and Cardiovascular Disease: A Presidential Advisory From the American Heart Association (free PDF)

Invited Commentary: Trimming the Fat on Diet Recommendations for a Healthy Heart: Emphasis on Eating Patterns over Dietary Restrictions (free)

Top Ten Things to Know: Dietary Fats and Cardiovascular Disease: A Presidential Advisory from the American Heart Association (free PDF)

AHA News: Advisory: Replacing saturated fat with healthier fat could lower cardiovascular risks (free)

News release: Replacing saturated fat with healthier fat may lower cholesterol as well as drugs in context of a healthy diet (free)

AHA no longer recommends decreasing total fat, but to replace saturated fats with polyunsaturated or monounsaturated fats. “Replacing saturated fat with healthier fat in the diet lowers cardiovascular disease risk as much as cholesterol-lowering statin drugs”

 

Evolocumab for Treatment of High Cholesterol: Clinical Effectiveness

19Jun
2017

Pathophysiology of Takotsubo Syndrome

16Jun
2017

Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction

15Jun
2017

Non–Vitamin K Antagonist Oral Anticoagulant Dosing in Patients With Atrial Fibrillation and Renal Dysfunction – Journal of The American College of Cardiology (link to abstract – $ for full-text)

Commentary: NOAC Doses: Just Stick to the Label – MedPage Today (free registration required)

“Among the 1,473 patients with a renal indication for dose reduction, 43.0% were potentially overdosed, which was associated with a higher risk of major bleeding”

 

Age-specific risks, severity, time course, and outcome of bleeding on long-term antiplatelet treatment after vascular events

15Jun
2017

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes

14Jun
2017

Canagliflozin and Cardiovascular and Renal Events in Type 2 Diabetes – New England Journal of Medicine (free)

Commentary: CANVAS: Canagliflozin Reduces CV Events, but at Cost of Amputations – Medscape (free registration required)

Patients treated with canagliflozin had a lower risk of cardiovascular events than those who received placebo but a greater risk of amputation and fractures. The benefits and harms were likely small. See interesting commentaries on the trade-offs by @AnilMakam, see Tweet 1Tweet 2Tweet 3Tweet 4Tweet 5Tweet 6Tweet 7Tweet 8; and Tweet 9.

 

A Test in Context: Fractional Flow Reserve: Accuracy, Prognostic Implications, and Limitations

14Jun
2017

Guidelines for the Management of Hypertension

13Jun
2017

Lower Risk of Heart Failure and Death in Patients Initiated on SGLT-2 Inhibitors?

12Jun
2017

Serum uric acid levels and multiple health outcomes

8Jun
2017

Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies – The BMJ (free)

Observational studies suggest that high serum uric acid levels are associated with multiple health outcomes, including cardiovascular and metabolic diseases. This review findings suggest there is a clear association only for gout and nephrolithiasis.

 

Pharmacologic Management of Newly Detected Atrial Fibrillation

7Jun
2017

Thirty-Year Mortality After Coronary Artery Bypass Graft Surgery

7Jun
2017

Thirty-Year Mortality After Coronary Artery Bypass Graft Surgery: A Danish Nationwide Population-Based Cohort Study – Circulation: Cardiovascular Quality and Outcomes (link to abstract – $ for full-text)

Commentary: Many good years after heart bypass surgery, but something happens after ten years – Aarhus University, via Science Daily (free)

“For patients who make it through the first month after the operation is close to that of the population in general. But 8-10 years after a heart bypass operation, mortality increases by 60-80 per cent” (from Science Daily)

 

Home blood pressure monitors inaccurate 70 percent of the time?

7Jun
2017

Tricuspid Valve Dysfunction After Pacemaker or ICD Implant

6Jun
2017

Tricuspid Valve Dysfunction After Pacemaker or ICD Implant – American College of Cardiology, Latest in Cardiology (free)

Key points to remember from a recent review of tricuspid valve dysfunction following pacemaker (PPM) or implantable cardioverter-defibrillator (ICD) placement (link to original abstract – $ for full-text)

 

Carotid Artery Stenting Versus Endarterectomy for Stroke Prevention

5Jun
2017

Carotid Artery Stenting Versus Endarterectomy for Stroke Prevention: A Meta-Analysis of Clinical Trials – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: CAS vs. CEA for Stroke Prevention – American College of Cardiology, Latest in Cardiology (free)

“CAS and CEA were associated with similar rates of a composite of periprocedural death, stroke, MI, or nonperiprocedural ipsilateral stroke. The risk of long-term overall stroke was significantly higher with CAS, and was mostly attributed to periprocedural minor stroke”.

 

Chocolate intake and risk of clinically apparent atrial fibrillation

4Jun
2017

Drug-Drug Interactions With Statins and HIV Medications

4Jun
2017

Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality

1Jun
2017

Systolic Blood Pressure Reduction and Risk of Cardiovascular Disease and Mortality: A Systematic Review and Network Meta-analysis – JAMA Cardiology (free) (RT @GreenlandRohan see Tweet)

Commentaries: Reducing blood pressure below recommended targets significantly reduces CVD, mortality risk – Clinical Advisor (free registration required) And New Review Supports Aggressive BP Targets – MedPage Today (free registration required)

Ideal blood pressure targets are controversial and recommendations vary across hypertension guidelines. This new meta-analysis suggests the risk of cardiovascular disease would be lowest with a systolic blood pressure between 120-124 mmHg.

 

NTproBNP – A blood test threshold for diagnosing heart failure in general practice is reviewed

1Jun
2017

A blood test threshold for diagnosing heart failure in general practice is reviewed – NIHR Signal (free)

Original article: Primary care REFerral for EchocaRdiogram (REFER) in heart failure: a diagnostic accuracy study (free)

“Most accurate diagnosis for heart failure in general practice came from using NTproBNP level at a low cut-off of ≥125 pg/ml” (RT @NIHR_DCsee Tweet)

 

Maternal and Fetal Outcomes of Anticoagulation in Pregnant Women With Mechanical Heart Valves

1Jun
2017

Maternal and Fetal Outcomes of Anticoagulation in Pregnant Women With Mechanical Heart Valves – Journal of The American College of Cardiology (free)

Commentaries: Warfarin OK in Expectant Moms with Mechanical Heart Valve – MedPage Today (free registration required) AND Anticoagulation in Pregnant Women With Mechanical Valves – American College of Cardiology, Latest in Cardiology (free) (RT @keaglemd see Tweet)

In this meta-analysis, warfarin was associated with lower risk of adverse maternal outcomes, whereas LMWH was associated with lower risk of adverse fetal outcomes.

 

Recommendations for the Use of Mechanical Circulatory Support

31May
2017

B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction

30May
2017

B-Blockers and Mortality After Acute Myocardial Infarction in Patients Without Heart Failure or Ventricular Dysfunction – Journal of The American College of Cardiology (free)

Commentary: Some heart attack patients may not benefit from beta blockers – University of Leads, via Science Daily (free)

Large cohort suggests there may be no benefit in continuing B-Blockers in patients who do not develop heart failure or ventricular dysfunction after myocardial infarction.

 

Management of pericardial disease

30May
2017

Current guidelines on prevention with a focus on dyslipidemias

30May
2017

Review: Current guidelines on prevention with a focus on dyslipidemias – Cardiovascular Diagnosis & Therapy (free)

Review comparing current recommendations for the treatment of dyslipidemia.

 

Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use

26May
2017

Cardiovascular Toxicity of Illicit Anabolic-Androgenic Steroid Use – Circulation (link to abstract – $ for full-text)

Commentaries: Anabolic Steroid Use Linked With Myocardial Dysfunction and Accelerated Atherosclerosis – TCTMD (free) AND Chronic anabolic steroid use may damage heart – American Heart Association News (free)

“The findings are a public health concern, given that as many as 1% of young men, not all of them athletes, may use these agents” (from TCTMD above).

 

Thrombolysis may reduce complications of deep vein thrombosis

26May
2017

Thrombolysis may reduce complications of deep vein thrombosis – NIHR Signal (free)

Original article: Thrombolysis for acute deep vein thrombosis – Cochrane Library (Link to abstract – $ for full-text)

Thrombolysis reduced post-thrombotic syndrome, but lead to more bleeding complications than standard anticoagulation. “Individuals with clots in the pelvis and thigh, which carry higher risk of complications, may be likely to gain most benefit”.

 

Diagnostic accuracy of post-mortem CT

26May
2017

Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease

25May
2017

Development and validation of QRISK3 risk prediction algorithms to estimate future risk of cardiovascular disease: prospective cohort study – BMJ (free)

Recommended: New QRISK-3 2017 Calculator (free)

QRISK-3 risk prediction model was developed with data from 7.89 million patients in the derivation cohort and 2.67 million patients in the validation cohort. QRISK-3 includes more factors than QRISK2 to help enable doctors to identify those at most risk of heart disease and stroke. New risk factors include: 1) Chronic kidney disease, which now includes stage 3 CKD; 2) Migraine; 3) Use of corticosteroids; 4) Systemic lupus erythematosus (SLE); 5) Use of atypical antipsychotics; 6) Severe mental illness; 7) Erectile dysfunction; 8) and Systolic blood pressure variability.

 

Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease

25May
2017

Complete versus culprit-only revascularisation in ST elevation myocardial infarction with multi-vessel disease – Cochrane Library (link to abstract – $ for full-text) (RT @Gas_Craic see Tweet)

“Compared with culprit-only intervention, the complete revascularisation strategy may be superior due to lower proportions of long-term cardiovascular mortality, long-term revascularisation, and long-term non-fatal myocardial infarction, but these findings are based on evidence of very low quality”

 

Perioperative management of patients on direct oral anticoagulants

24May
2017

Cardiopulmonary Resuscitation in Adults and Children With Mechanical Circulatory Support

24May
2017

Trans-fat – The Worst Fat in the Food Supply

24May
2017

The Worst Fat in the Food Supply – The New York Times (10 articles per month are free)

See also a recent study and commentaries on the effects of trans-fat bans in our April 23rd issue (see #1)

Trans-fat bans seem to be reducing cardiovascular deaths.

 

Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults

23May
2017

Effect of Statin Treatment vs Usual Care on Primary Cardiovascular Prevention Among Older Adults: The ALLHAT-LLT Randomized Clinical Trial – JAMA Internal Medicine (free) (RT @EricTopol see Tweet)

Editorial: Risks of Statin Therapy in Older Adults (free)

Commentaries: Older adults may not benefit from taking statins to prevent heart disease – Medical News Today (free) AND Pravastatin Doesn’t Improve Clinical Outcomes in Seniors – Physician’s First Watch (free)

Patients > 65 years with moderate hyperlipidemia and hypertension had no benefit from pravastatin for primary prevention. “A nonsignificant direction toward increased all-cause mortality with pravastatin was observed among adults 75 years and older” (HR 1.34; 95% CI, 0.98-1.84; P = .07).

 

Science Has Begun Taking Gluten Seriously

19May
2017

Science Has Begun Taking Gluten Seriously – The Atlantic (free)

Original article: Long term gluten consumption in adults without celiac disease and risk of coronary heart disease: prospective cohort study – The BMJ (free)

“New research from Harvard and Columbia says gluten does not cause heart disease. Why is that even a question?”

 

Reducing Recurrent Stroke With PFO Closure

19May
2017

Finally, Success Reducing Recurrent Stroke With PFO Closure – Medscape (free registration required)

Two randomized trials presented at the 3rd European Stroke Organization Conference (ESOC) 2017 showed that in carefully selected stroke patients in whom Patent Foramen Oval (PFO) was suspected to be a cause of their strokes, a reduction in recurrent stroke was observed with PFO closure.

 

Global, Regional, and National Burden of Cardiovascular Diseases

18May
2017

How to rein in the widening disease definitions that label more healthy people as sick

17May
2017

Cardiovascular events and all-cause mortality associated with sulphonylureas compared with other antihyperglycaemic drugs

16May
2017

Prevalence of Elevated Cardiovascular Risks in Young Adults

16May
2017

Prevalence of Elevated Cardiovascular Risks in Young Adults: A Cross-sectional Analysis of National Health and Nutrition Examination Surveys – Annals of Internal Medicine (link to abstract – $ for full-text)

Source: Study Assesses ASCVD Risk in Non-Diabetic Adults – American College of Cardiology, Latest in Cardiology (free)

In the absence of diabetes, smoking or hypertension, most adult men younger than 40 years and adult women younger than 50 years are at low risk of cardiovascular disease (defined as < 5% in 10 years, usually not eligible for statin therapy) and may not benefit from cholesterol screening.

 

BTS guideline for oxygen use in adults in healthcare and emergency settings

16May
2017

Peripheral Artery Disease Guideline

15May
2017

Reducing brain injury following cardiopulmonary resuscitation

11May
2017

Risk of acute myocardial infarction with NSAIDs

11May
2017

Drug-Eluting Stents Versus Coronary Artery Bypass Grafting in Unprotected Left Main Coronary Narrowing

11May
2017

Mortality from different causes associated with meat, heme iron, nitrates, and nitrites

10May
2017

Meta-analysis: Mortality from different causes associated with meat, heme iron, nitrates, and nitrites in the NIH-AARP Diet and Health Study: population based cohort study – The BMJ (free)

High intakes of red and processed meat are associated with increased risks of all-cause mortality and death due to nine different causes.

 

Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality

10May
2017

Atrial Fibrillation: Epidemiology, Pathophysiology, and Clinical Outcomes

9May
2017

Intravenous fluid therapy in adults in hospital – NICE Guideline

9May
2017

Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today

6May
2017

Research letter: Applicability of the IMPROVE-IT Trial to Current Patients With Acute Coronary Syndrome – JAMA Internal Medicine (link to abstract – $ for full text)

Source: Cardiac Patients in Trials Don’t Reflect Real-World Populations – MedPage Today (free registration required)

Related: Exclusion of patients with concomitant chronic conditions in ongoing randomised controlled trials targeting 10 common chronic conditions and registered at ClinicalTrials.gov: a systematic review of registration details – BMJ Open (free) AND Do cancer clinical trials exaggerate the real-world benefits of drugs? – STAT News (free)

Patients in clinical trials are often younger, healthier (with less comorbidities), better plugged in to the health care system, better educated and wealthier, indicating that the external validity or generalizability of much of the current evidence to real-world settings may be relatively weak.

 

Selection of patients for intra-arterial treatment for acute ischaemic stroke

4May
2017

Selection of patients for intra-arterial treatment for acute ischaemic stroke: development and validation of a clinical decision tool in two randomised trials – The BMJ (free)

New decision tool: MR CLEAN-R Registry (free)

This new clinical decision tool will improve the selection of patients with acute ischemic stroke who will benefit the most from intra-arterial treatment.

 

Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest

4May
2017

Bystander Efforts and 1-Year Outcomes in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (Link to abstract – $ for full-text)

Quick Take Video Summary: Bystander Efforts in Out-of-Hospital Cardiac Arrest (free)

Commentary: Bystander CPR and Defibrillation Are Associated with Better Long-Term Outcomes – Journal Watch (free)

In patients who have initially survived after out-of-hospital cardiac arrest, those who were submitted to bystander CPR and defibrillation had lower risk of brain damage, nursing home admission and death after one year when compared to patients who survived but were not submitted to bystander CPR.

 

PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library

3May
2017

Systematic review: PCSK9 inhibitors for prevention of cardiovascular disease – Cochrane Library (free summary – $ for full-text))

The evidence so far suggests that PCSK9 inhibitor use probably leads to little or no difference in mortality and leads to a modest absolute risk reduction (often less than 1%) in cardiovascular events in high-risk patients.

 

Effect of Using the HEART Score in Patients With Chest Pain in the Emergency Department

2May
2017

Echocardiography and lung ultrasonography for the assessment and management of acute heart failure

2May
2017

CPAP Use in Obstructive Sleep Apnea: What a Cardiologist Needs to Know

2May
2017

ACCF/AHA Guideline for the Management of Heart Failure

1May
2017

Normal-Weight Central Obesity and Risk for Mortality

28Apr
2017

Advil, Motrin and other NSAIDs painkillers should be prescription only, Danish study says

28Apr
2017

Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure

27Apr
2017

Guidelines For Management Of Dyslipidemia And Prevention Of Cardiovascular Disease

27Apr
2017

Prevention and Management of Cardiovascular Disease Risk in Primary Care

26Apr
2017

Association between active commuting and incident cardiovascular disease, cancer, and mortality

21Apr
2017

Syncope and Its Impact on Occupational Accidents and Employment

20Apr
2017

β-Blocker Exposure in Pregnancy and Risk of Fetal Cardiac Anomalies

20Apr
2017

ACC/AHA vs. USPSTF statin guidelines

19Apr
2017

Comparison of Recommended Eligibility for Primary Prevention Statin Therapy Based on the US Preventive Services Task Force Recommendations vs the ACC/AHA Guidelines – JAMA (link to abstract – $ for full-text)

See also: ACC/AHA vs. USPSTF statin guidelines – Cardiology News (free)

Although recommended by most guidelines for individuals at high risk, there is still some controversy over prescribing statins for primary prevention and over what patients benefit the most – see related commentary: Cholesterol-lowering statin therapy for healthy people is not as simple as ‘yes’ or ‘no’ – The Pharmaceutical Journal (free)

Adherence to the 2016 USPSTF recommendations for statin therapy, compared with the 2013 ACC/AHA guidelines, could lead to a lower number of individuals (an estimated difference of 9.3 million individuals in the U.S. population) recommended for primary prevention statin therapy.

 

Single Cardiac Troponin Test Plus ECG Can Quickly Rule Out MI

19Apr
2017

Rapid Rule-out of Acute Myocardial Infarction with a Single High-Sensitivity Cardiac Troponin T Measurement Below the Limit of Detection: A Collaborative Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

See also: High-Sensitivity Troponin T Test Rules Out AMI in ED – Medscape (free registration required) AND Meta-Analysis: Single Cardiac Troponin Test Plus ECG Can Quickly Rule Out MI – Physician’s First Watch (free)

“This analysis indicates that a nonischemic ECG and a single negative High-Sensitivity Cardiac Troponin T only misses about 1 in 100 myocardial infarctions – and can provide rapid, useful information in an assessment.” (from Physician’s First Watch commentary above).

 

New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management

18Apr
2017

Can machine-learning improve cardiovascular risk prediction using routine clinical data?

17Apr
2017

Can machine-learning improve cardiovascular risk prediction using routine clinical data? – PLOS One (free)

See also: Self-taught artificial intelligence beats doctors at predicting heart attacks – Science (free)

“When expert MD guidelines are outperformed by machine learning for heart risk prediction” (RT @EricTopol see Tweet)

 

Screening for Endocrine Hypertension

14Apr
2017

Screening for Endocrine Hypertension: An Endocrine Society Scientific Statement (free)

Source: Screen for Endocrine Hypertension, Endocrine Society Says – Medscape (free registration required)

“The statement provides guidance on screening for 15 hormonal disorders that present with hypertension and that can be potentially cured with surgery or treated with medication” (from Medscape commentary above).

 

Banning trans fats in New York prevented thousands of heart attacks

13Apr
2017

Multivitamins are probably a waste of money

12Apr
2017

Vitamins and the Failure of Free-Market Health – The Atlantic (free)

“The booming dietary-supplement industry is plagued by outlandish claims, undermining credible science, and seeding confusion”.

 

Effect of Baseline Nutritional Status on Long-term Multivitamin Use and Cardiovascular Disease Risk – JAMA Cardiology (link to abstract – $ required for full-text)

See also: Multivitamins may not improve heart health in men – UPI (free) AND Other recent commentary on multivitamins: Multivitamins a waste of money and just create ‘very expensive urine’ – The Guardian (free)

“Multivitamin use does not prevent major CV disease events in men, regardless of baseline nutritional status” (RT @CaulfieldTim)

 

Respiratory effect of beta-blockers in people with asthma and cardiovascular disease

11Apr
2017

Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study – BMC Medicine (free) (RT @atscommunity)

Cardioselective beta-blockers, mostly atenolol and bisoprolol in this cohort, were not associated with increased risk of moderate or severe asthma exacerbations. In contrast, non-selective beta-blockers, mostly sotalol and carvedilol in this cohort, were associated with increased risk.

 

Achieved blood pressure and cardiovascular outcomes in high-risk patients

11Apr
2017

 

Achieved blood pressure and cardiovascular outcomes in high-risk patients: results from ONTARGET and TRANSCEND trials – The Lancet (link to abstract – $ required for full-text) (RT @AnilMakam “Lower achieved blood pressure in high risk patients for cardiovascular disease do WORSE” see Tweets)

In high-risk patients, patients who achieved a systolic blood pressure < 120 mmHg or a diastolic blood pressure < 70 mmHg had HIGHER risk of complications. “These data suggest that the lowest blood pressure possible is not necessarily the optimal target for high-risk patients”

 

Hypertension Canada’s 2017 Guidelines

10Apr
2017

Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients

10Apr
2017

Surgical or Transcatheter Aortic-Valve Replacement in Intermediate-Risk Patients – New England Journal of Medicine (link to abstract – $ required for full text)

Quick Take Video Summary: SURTAVI Study: TAVR versus Open Surgery (free)

See this and other highlights from the American College of Cardiology’s 66th Annual Scientific Session (some articles are no longer free)

This innovative technology seems to be useful for patients with aortic stenosis at high risk for surgery. In this new study, it was noninferior to surgery at 2 years of follow-up in old patients (averaged nearly 80 years) at intermediate risk. Longer follow up data will be important to see if it is a suitable alternative for younger patients.

 

Benefits of Endovascular Treatment for Stroke Last at Least 2 Years

7Apr
2017

Singapore Ministry of Health Clinical Practice Guidelines: Lipids

7Apr
2017

Inhaled Corticosteroids May Raise Women’s Risk of the Metabolic Syndrome

6Apr
2017

Australian Clinical Guidelines for the Management of Acute Coronary Syndromes

6Apr
2017

Can low-dose aspirin can reduce risk of death from cancer?

6Apr
2017

Cardiometabolic Abnormalities Among Normal-Weight Persons From Five Racial/Ethnic Groups

5Apr
2017

Cardiometabolic Abnormalities Among Normal-Weight Persons From Five Racial/Ethnic Groups in the United States: A Cross-sectional Analysis of Two Cohort Studies – Annals of Internal Medicine (link to abstract – $ required for full-text)

Sources: Certain Racial/Ethnic Groups More Likely to Have Cardiometabolic Abnormalities at Normal Weight – Physician’s First Watch (free) AND Cardiovascular Risk High Among Some Normal Weight Minorities – Medscape (free registration required)

Compared with whites, all racial/ethnic minority groups had higher prevalence of metabolic abnormalities, with a high prevalence even in persons with normal weight. The prevalence of metabolic abnormalities in whites with a BMI of 25 kg/m2 corresponded to the prevalence in BMI values of 22.9 kg/m2 in African Americans, 21.5 kg/m2 in Hispanics, 20.9 kg/m2 in Chinese Americans, and 19.6 kg/m2 in South Asians.

 

Prognosis of undiagnosed chest pain

5Apr
2017

Prognosis of undiagnosed chest pain: linked electronic health record cohort study – The BMJ (free)

See also: Patients with Undiagnosed Chest Pain Still at Cardiovascular Risk – Physician’s First Watch (free)

“Chest pain rarely harmless. Even if undiagnosed 6 months after first presentation linked to increased cardiac events.” (RT @pascalmeier74)

 

American College of Radiology (ACR) Appropriateness Criteria Adds Topics

4Apr
2017

ACR Appropriateness Criteria Adds Topics, Covers More Clinical Variants Than Ever Before (free)

Browse Appropriateness Criteria Topics (free)

Source: Newswise

This comprehensive guide from American College of Radiology (ACR) covers 230 topics with more than 1,100 clinical indications and has just been updated. It is a very useful resource for doctors in all specialties to guide which exam is most appropriate in each clinical situation.

 

Insomnia associated with increased risk of heart attack and stroke

4Apr
2017

Anemia and blood transfusion in the critically ill patient with cardiovascular disease

3Apr
2017

History of Periodontitis and Edentulism as Predictors of Cardiovascular Disease, Stroke, and Mortality

31Mar
2017

History of Periodontitis Diagnosis and Edentulism as Predictors of Cardiovascular Disease, Stroke, and Mortality in Postmenopausal Women – Journal of the American Heart Association (free) (RT @kamleshkhunti)

Press release: Gum disease, tooth loss may increase postmenopausal women’s risk of death – American Heart Association Rapid Access Journal Report (free)

History of periodontal disease was associated with a 12 percent higher risk of death from any cause and loss of all natural teeth was associated with a 17 percent higher risk of death from any cause.

 

Non–Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation and Valvular Heart Disease

30Mar
2017

Non–Vitamin K Antagonist Oral Anticoagulants in Patients With Atrial Fibrillation and Valvular Heart Disease – Journal of the American College of Cardiology (free)

Source: SciCombinator

Except for patients with moderate/severe mitral stenosis or mechanical heart valves, who were excluded in most trials, high-dose NOACs was as effective and safe for patients with valvular heart disease as for patients without valvular disorders.

 

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