Related guidelines: Guidelines on eosinophilic esophagitis: evidence-based statements and recommendations for diagnosis and management in children and adults – United European Gastroenterology (free) Management Guidelines of Eosinophilic Esophagitis in Childhood – Journal of Pediatric Gastroenterology and Nutrition (free) AND ACG Clinical Guideline: Evidenced Based Approach to the Diagnosis and Management of Esophageal Eosinophilia and Eosinophilic Esophagitis (EoE) (free)
Commentary: Probiotics and fish oil in pregnancy may reduce allergies in children – NHS Choices (free) AND Diet During Pregnancy May Cut Offspring Allergy Risk – MedPage Today (free registration required) AND Probiotics and Fish Oil During Pregnancy May Curb Allergies in Kids – The New York Times (10 articles per month are free)
Editorial: Escalating Inhaled Glucocorticoids to Prevent Asthma Exacerbations (free for a limited period)
Trial 1: Quintupling Inhaled Glucocorticoids to Prevent Childhood Asthma Exacerbations – The New England Journal of Medicine (free for a limited period)
Trial 2: Quadrupling Inhaled Glucocorticoid Dose to Abort Asthma Exacerbations – The New England Journal of Medicine (free for a limited period)
Effect of Oral Administration of a Mixture of Probiotic Strains on SCORAD Index and Use of Topical Steroids in Young Patients With Moderate Atopic Dermatitis: A Randomized Clinical Trial – JAMA Dermatology (link to abstract – $ for full-text)
Commentaries: Probiotics may improve pediatric AD symptoms – DermatologyTimes (free) AND Probiotics May Improve Pediatric AD Symptoms – MedPage Today (free registration required)
Commentaries: Flu vaccine safe for individuals with egg allergy – Clinical Advisor (free) And Egg Allergy No Bar to Flu Vax, Experts Say – MedPage Today (free)
Prenatal and Early-Life Fructose, Fructose-Containing Beverages, and Mid-Childhood Asthma – Annals of the American Thoracic Society (link to abstract – $ for full-text)
Commentaries: Sugary fruit juices and drinks linked to childhood asthma – NHS Choices (free) AND Toddler and maternal fructose intake linked to asthma – OnMedica (free) AND Moms’ Soda Habit in Pregnancy May Boost Kids’ Odds for Asthma – Medline Plus (free) AND Childhood asthma linked to high maternal sugar intake during pregnancy – Medical News (free) AND Sugary Diet During Pregnancy May Increase Asthma Risk in Children – The New York Times (10 articles per month are free)
Commentaries: Montelukast Tied to Psychiatric Adverse Events in Kids, Adults – Medscape (free registration required) AND Asthma Drug, Montelukast, Tied to Nightmares, Depression – Drugs.com (free)
Original article: Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults – Cochrane Library (link to abstract – $ for full-text)
“Tailoring asthma interventions based on sputum eosinophils is beneficial in reducing the frequency of asthma exacerbations in adults with asthma. Adults with frequent exacerbations and severe asthma may derive the greatest benefit from this additional monitoring test”.
Efficacy of a 4-Food Elimination Diet for Children With Eosinophilic Esophagitis – Clinical Gastroenterology and Hepatology (link to abstract – $ for full-text)
Commentaries: Elimination Diet for Eosinophilic Esophagitis — Are Four Foods as Good as Six? – Journal Watch (free) Four-Food Elimination Diet Can Treat Eosinophilic Esophagitis in Children – NewsWise (free)
Intravenous Corticosteroid Premedication Administered 5 Hours Before CT Compared with a Traditional 13-Hour Oral Regimen – Radiology (link to abstract – $ for full-text)
Source: Journal Watch ($)
“Accelerated intravenous premedication with corticosteroids beginning 5 hours before contrast-enhanced CT has a breakthrough reaction rate noninferior to that of a 13-hour oral premedication regimen”.
Long-term clinical and immunological effects of probiotic and peanut oral immunotherapy after treatment cessation: 4-year follow-up of a randomised, double-blind, placebo-controlled trial – The Lancet Child & Adolescent Health (link to abstract – $ for full-text)
Commentaries: Benefits of Immunotherapy-Probiotic Combo for Peanut Allergy Sustained at 4 Years – Physician’s First Watch (free) AND Peanut Allergy: Is Oral Immunotherapy With Probiotic a Cure? – Medscape (free registration required) AND Peanut Allergy Tx Efficacy Examined in 4-Year Follow-Up Study – MPR (free)
Commentary: Food Allergy: Consensus Report Stresses Diagnostic Accuracy – Medscape (free registration required)
Commentaries: Sugar intake during pregnancy is associated with allergy and allergic asthma in children – Queen Mary University of London Science Daily (free) AND Mom’s sweet tooth may be linked to child’s allergies, study says – CNN (free) AND Eating Sugar During Pregnancy Is Linked to Kids’ Allergies – TIME (free)
Observational study suggests maternal intake of sugar during pregnancy may increase allergic problems in offspring.
Clinical Review: Prevention and Management of Cow’s Milk Allergy in Non-Exclusively Breastfed Infants – Nutrients (free)
Effect of azithromycin on asthma exacerbations and quality of life in adults with persistent uncontrolled asthma (AMAZES): a randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Allergy Testing in Children With Low-Risk Penicillin Allergy Symptoms – Pediatrics (link to abstract – $ for full-text)
Commentaries: Penicillin Allergy in Children Substantially Overreported – Medscape (free registration required) AND No Penicillin Allergy Found in Most Kids with Non-Specific Symptoms – MedPage Today (free registration required) AND Low risk allergy symptoms not linked to true penicillin allergy – 2 minute medicine (free)
Related article: Penicillin Allergy Is Not Necessarily Forever – JAMA (free)
“Analysing the DNA, RNA and protein of single cells is transforming our understanding of the immune system, say Amir Giladi and Ido Amit”.
Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: No Benefit From Corticosteroids for Acute, Simple Urticaria – Medscape (free registration required) AND Got hives? Hold the steroids – American College of Emergency Physicians, via EurekAlert (free)
Timing of food introduction and development of food sensitization in a prospective birth cohort – Pediatric Allergy and Immunology (link to abstract – $ for full-text)
Editorial: Nut allergy guideline (free)
See also related guidelines (U.S.) and commentaries recommending early introduction of peanuts to prevent allergies in our January 6 issue, see #1 and #2.
Too Clean for Our Children’s Good? – The New York Times (10 articles per month are free)
According to the “hygiene hypothesis”, some exposure to germs and microorganisms might be good for us because it helps develop the immune system.
Editorial: Rotavirus Vaccines – A New Hope (free)
Quick Take Video Summary: Efficacy of Heat-Stable Oral Rotavirus Vaccine (free)