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Allergy & Immunology

Study | Removal of thymus in adults linked to increased death, cancer incidence

4 Aug, 2023 | 12:09h | UTC

Health Consequences of Thymus Removal in Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Doctors have long considered the thymus expendable. But could removing it be fatal? – Science

The thymus withers away after puberty. But it may be important for adults – Science News

Thymus gland critical for adult health, study finds – News Medical

 

Commentary on Twitter

 


Review | Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management

4 Aug, 2023 | 11:49h | UTC

Autoimmunity and postural orthostatic tachycardia syndrome: Implications in diagnosis and management – Cleveland Clinic Journal of Medicine

 


RCT | Maternal egg intake in early neonatal period does not impact infant egg allergy risk

2 Aug, 2023 | 13:47h | UTC

Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 


An ESPGHAN position paper on the diagnosis, management and prevention of cow’s milk allergy

31 Jul, 2023 | 14:28h | UTC

An ESPGHAN position paper on the diagnosis, management and prevention of cow’s milk allergy – Journal of Pediatric Gastroenterology and Nutrition

 


Systematic Review | Medical treatment of eosinophilic esophagitis

21 Jul, 2023 | 13:27h | UTC

Medical treatment of eosinophilic esophagitis – Cochrane Library

Summary: Medical treatments for eosinophilic esophagitis – Cochrane Library

Related:

RCT | Study finds both one-food and six-food elimination diets are effective initial options for eosinophilic esophagitis

M-A | Efficacy of elimination diets in eosinophilic esophagitis

RCT | Dupilumab in adults and adolescents with eosinophilic esophagitis

A meta-analysis on randomized controlled trials of treating eosinophilic esophagitis with budesonide – Annals of Medicine

A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions – Gastroenterology

British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults – Gut

 


RCT | Direct oral challenge noninferior to skin testing followed by direct oral challenge in low-risk penicillin allergy patients

18 Jul, 2023 | 13:54h | UTC

Efficacy of a Clinical Decision Rule to Enable Direct Oral Challenge in Patients With Low-Risk Penicillin Allergy: The PALACE Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

See also: Visual Abstract

News Release: World-first clinical trial to help millions with penicillin allergies – Vanderbilt University Medical Center

Commentary: Trial supports use of direct oral challenge for penicillin allergy – CIDRAP

 


Guideline | Antibiotic therapy in patients with suspected antibiotic allergy

17 Jul, 2023 | 13:59h | UTC

The Dutch Working Party on Antibiotic Policy (SWAB) guideline for the approach to suspected antibiotic allergy – Clinical Microbiology and Infection

 


Guidelines | Management of atopic dermatitis in adults with topical therapies

14 Jul, 2023 | 12:48h | UTC

Guidelines of care for the management of atopic dermatitis in adults with topical therapies – Journal of the American Academy of Dermatology

News Release: American Academy of Dermatology issues updated guidelines for the management of atopic dermatitis in adults with topical therapies

 


Impact of newborn screening on severe combined immunodeficiency survival: results from a 36-year longitudinal study

14 Jul, 2023 | 12:45h | UTC

Measuring the effect of newborn screening on survival after haematopoietic cell transplantation for severe combined immunodeficiency: a 36-year longitudinal study from the Primary Immune Deficiency Treatment Consortium – The Lancet (link to abstract – $ for full-text)

News Release: Newborn screening facilitates early identification of infants with severe combined immunodeficiency – NIH/National Institute of Allergy and Infectious Diseases/News Medical

 

Commentary on Twitter

 


Review | Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA): two sides of the same coin

7 Jul, 2023 | 16:01h | UTC

HES and EGPA: Two Sides of the Same Coin – Mayo Clinic Proceedings

 


Podcast | Wisely ordering autoantibodies

28 Jun, 2023 | 13:09h | UTC

#399 Wisely Ordering Autoantibodies – ACP IM2023 – The Curbsiders

 


Adrenaline auto-injector prescription for patients at risk of anaphylaxis: BSACI guidance for primary care

6 Jun, 2023 | 14:28h | UTC

Adrenaline auto-injector prescription for patients at risk of anaphylaxis: BSACI guidance for primary care – Clinical & Experimental Allergy

 


RCT | Dupilumab improves lung function and reduces exacerbations in COPD patients with elevated eosinophils

1 Jun, 2023 | 12:20h | UTC

Dupilumab for COPD with Type 2 Inflammation Indicated by Eosinophil Counts – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Dupilumab Improves Outcomes for COPD, Type 2 Inflammation in Randomized Trial – HCP Live

 

Commentary on Twitter

 


Guideline | Investigation and management of acute transfusion reactions

29 May, 2023 | 11:02h | UTC

Guideline on the investigation and management of acute transfusion reactions – British Journal of Haematology

 


RCT | Peanut patch therapy is effective in desensitizing young children with allergies, but raises risk of serious adverse events

15 May, 2023 | 13:10h | UTC

Phase 3 Trial of Epicutaneous Immunotherapy in Toddlers with Peanut Allergy – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Cohort Study | Autoimmune disorders’ incidence, prevalence & co-occurrence by age, sex, and socioeconomic status

8 May, 2023 | 13:14h | UTC

Incidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK – The Lancet (free for a limited period)

 

Commentary from the author on Twitter (thread – click for more)

 


Cohort Study | Idiopathic CD4 Lymphocytopenia linked to increased infection risk and cancer prevalence

5 May, 2023 | 15:16h | UTC

Reappraisal of Idiopathic CD4 Lymphocytopenia at 30 Years – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 


RCT | Efficacy and safety of tralokinumab in adolescents with moderate to severe atopic dermatitis

3 May, 2023 | 15:04h | UTC

Efficacy and Safety of Tralokinumab in Adolescents With Moderate to Severe Atopic Dermatitis: The Phase 3 ECZTRA 6 Randomized Clinical Trial – JAMA Dermatology

Commentary: Tralokinumab Efficacious, Well-Tolerated for Adolescents with Atopic Dermatitis – HCP Live

 

Commentary on Twitter

 


Immediate hypersensitivity reactions to antineoplastic agents – A practical guide for the oncologist

24 Apr, 2023 | 13:40h | UTC

Immediate hypersensitivity reactions to antineoplastic agents – A practical guide for the oncologist- Cancer Treatment Reviews (free for a limited period)

See Tweet from one of the authors with infographic and link to free full text here

 


Identifying perioperative anaphylaxis in Japan: epidemiology, allergens, and diagnostic tools

17 Apr, 2023 | 13:10h | UTC

The Japanese Epidemiologic Study for Perioperative Anaphylaxis, a prospective nationwide study: allergen exposure, epidemiology, and diagnosis of anaphylaxis during general anaesthesia – British Journal of Anaesthesia

 


M-A | Timing of allergenic food introduction and risk of immunoglobulin E–mediated food allergy

11 Apr, 2023 | 14:32h | UTC

Timing of Allergenic Food Introduction and Risk of Immunoglobulin E–Mediated Food Allergy: A Systematic Review and Meta-analysis – JAMA Pediatrics

News Release: Earlier introduction of allergenic foods in children may prevent food allergies – Imperial College London

Commentary: Allergenic Food Introduction Led to Fewer Allergies, Higher Withdrawal Rate from Intervention – HCP Live

Related:

Study | Public health policies should recommend introducing peanut products to infants at 4-6 months of age to prevent peanut allergy

AAP Updated Recommendations for Dietary Interventions to Prevent Atopic Disease

Timing of introduction of allergenic solids for infants at high risk – Canadian Paediatric Society

 

Commentary on Twitter

 


RCT | Baricitinib + topical corticosteroids effective in kids with moderate-severe atopic dermatitis

4 Apr, 2023 | 13:39h | UTC

Efficacy and safety of baricitinib in combination with topical corticosteroids in pediatric patients with moderate-to-severe atopic dermatitis with inadequate response to topical corticosteroids: results from a phase 3, randomized, double-blind, placebo-controlled study (BREEZE-AD PEDS) – British Journal of Dermatology

 


Cohort Study | Associations between fetal or infancy pet exposure and food allergies

3 Apr, 2023 | 13:26h | UTC

Associations between fetal or infancy pet exposure and food allergies: The Japan Environment and Children’s Study – PLOS One

 


RCT | Efficacy and safety of garadacimab, a factor XIIa inhibitor for hereditary angioedema prevention

31 Mar, 2023 | 13:26h | UTC

Efficacy and safety of garadacimab, a factor XIIa inhibitor for hereditary angioedema prevention (VANGUARD): a global, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter (thread – click for more)

 


Two phase 3 trials of lebrikizumab for moderate-to-severe atopic dermatitis

21 Mar, 2023 | 13:23h | UTC

Two Phase 3 Trials of Lebrikizumab for Moderate-to-Severe Atopic Dermatitis – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Largest study to date of lebrikizumab supports its use for treatment of atopic dermatitis – George Washington University

Commentary: Lebrikizumab Effective for Adults, Teens With Atopic Dermatitis – HealthDay

 


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