Allergy & Immunology

Efficacy and safety of dupilumab in patients with severe chronic rhinosinusitis with nasal polyps (LIBERTY NP SINUS-24 and LIBERTY NP SINUS-52): results from two multicentre, randomised, double-blind, placebo-controlled, parallel-group phase 3 trials – The Lancet (link to abstract – $ for full-text)

 

Related Commentary on Twitter

 


Controlled Trial of Budesonide–Formoterol as Needed for Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Treatment Changes for Mild Asthma? – NEJM Journal Watch (free)

Just Presented at the 2019 Meeting of the American Thoracic Society.

 


World Tuberculosis Day | 24 March 2019

24 Mar, 2019 | 12:59h | UTC

Epidural analgesia for adults undergoing cardiac surgery with or without cardiopulmonary bypass – Cochrane Library (free)

Summary: Epidural analgesia for heart surgery with or without the heart lung machine in adults – Cochrane Library (free)

“Compared with systemic analgesia, epidural analgesia may reduce the risk of myocardial infarction, respiratory depression, and atrial fibrillation / atrial flutter, as well as the duration of tracheal intubation and pain, in adults undergoing cardiac surgery.”

 


A practical guide for pharmacists to successfully implement penicillin allergy skin testing – American Journal of Health-System Pharmacy (free)

“Less than 10% of patients labeled as having a penicillin allergy are confirmed as present upon skin testing. This labeling results in use of alternative antibiotics and thus unwanted adverse consequences including potentiated antimicrobial resistance, increased costs, and worse clinical outcomes.”

 


Review: Food Allergy and Anaphylaxis

3 Dec, 2018 | 11:39h | UTC

NAP6 Report: Anaesthesia, Surgery and Life-Threatening Allergic Reactions: Report and findings of the Royal College of Anaesthetists’ 6th National Audit Project (free PDF)

News Release: RCoA undertakes largest ever study of anaphylaxis in anaesthesia and surgery (free)

Infographic: Anaesthesia, Surgery and Life-Threatening Allergic Reactions (free PDF)

“The study found teicoplanin is 17-fold more likely to cause anaphylaxis than penicillin and similar drugs. As 90 per cent of patients who report penicillin allergy are in fact not allergic, better identification of true allergy would reduce risk”. (from News Release)

 


Review: Anaphylaxis

22 Feb, 2018 | 23:24h | UTC

Review: New Trends in Anaphylaxis

27 Dec, 2017 | 20:51h | UTC

Consensus on Allergic Rhinitis

26 Dec, 2017 | 20:03h | UTC

Review: Severe forms of food allergy

17 Oct, 2017 | 17:42h | UTC

Review: Human Milk and Allergic Diseases

24 Sep, 2017 | 00:13h | UTC

Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults – Cochrane Library (free)

Original article: Tailored interventions based on sputum eosinophils versus clinical symptoms for asthma in children and adults – Cochrane Library (link to abstract – $ for full-text)

“Tailoring asthma interventions based on sputum eosinophils is beneficial in reducing the frequency of asthma exacerbations in adults with asthma. Adults with frequent exacerbations and severe asthma may derive the greatest benefit from this additional monitoring test”.

 


Intravenous Corticosteroid Premedication Administered 5 Hours Before CT Compared with a Traditional 13-Hour Oral Regimen – Radiology (link to abstract – $ for full-text)

Source: Journal Watch ($)

“Accelerated intravenous premedication with corticosteroids beginning 5 hours before contrast-enhanced CT has a breakthrough reaction rate noninferior to that of a 13-hour oral premedication regimen”.

 


Cardiac involvement in DRESS syndrome

7 Jul, 2017 | 13:48h | UTC

Immunology, one cell at a time

4 Jul, 2017 | 21:13h | UTC

Immunology, one cell at a time – Nature News (free)

“Analysing the DNA, RNA and protein of single cells is transforming our understanding of the immune system, say Amir Giladi and Ido Amit”.

 


Efficacy of Recombinant Influenza Vaccine in Adults 50 Years of Age or Older – New England Journal of Medicine (link to abstract – $ for full-text)

“Say bye to egg-grown flu vaccine? Recombinant vaccines are a little more effective & much quicker to adapt” (RT @RichardLehman1 see Tweet and brief commentaries on the study)

 


Autoimmune gastritis

4 Jun, 2017 | 19:06h | UTC

Angioedema in the emergency department

25 May, 2017 | 14:46h | UTC

Maternal asthma: Management strategies

19 Apr, 2017 | 14:16h | UTC

Too Clean for Our Children’s Good?

18 Apr, 2017 | 14:04h | UTC

Too Clean for Our Children’s Good? – The New York Times (10 articles per month are free)

According to the “hygiene hypothesis”, some exposure to germs and microorganisms might be good for us because it helps develop the immune system. 

 


Eosinophilia in Primary Care

4 Apr, 2017 | 19:30h | UTC
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