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Review | Diagnosing delirium in perioperative and intensive care medicine

3 Aug, 2023 | 13:09h | UTC

Diagnosing delirium in perioperative and intensive care medicine – Current Opinion in Anesthesiology

 

Review | Atypical hyperplasia of the breast: Clinical cases and management strategies

3 Aug, 2023 | 13:07h | UTC

Atypical hyperplasia of the breast: Clinical cases and management strategies – Cleveland Clinic Journal of Medicine

 

WHO | Seven out of 10 people protected by at least one tobacco control measure

2 Aug, 2023 | 14:14h | UTC

News Release: Seven out of 10 people protected by at least one tobacco control measure – World Health Organization

See also: MPOWER measures

Report: WHO report on the global tobacco epidemic, 2023: protect people from tobacco smoke – World Health Organization

Commentaries:

While Anti-Smoking Policies Cover 70% of Global Population, Taxation is Under-Utilised – Health Policy Watch

Expert reaction to WHO report on the global tobacco epidemic 2023 – Science Media Centre

 

Commentary on Twitter

 

USPSTF Draft Statement | Insufficient evidence for screening children under 5 years for speech and language delay

2 Aug, 2023 | 14:13h | UTC

Speech and Language Delay and Disorders in Children: Screening – U.S. Preventive Services Task Force

Commentary:

USPSTF issues statement on speech, language disorder screenings for all children up to 5 years – Contemporary Pediatrics

USPSTF: Evidence Lacking for Screening for Speech Delays in Young Children – HealthDay

 

Perspective | The most important trial in modern cardiology (Critical appraisal of the ISCHEMIA trial)

2 Aug, 2023 | 14:11h | UTC

Chapter 3: The Most Important Trial in Modern Cardiology – Sensible Medicine

See also:

Chapter 1: What Does it Mean to Discover a Coronary Blockage? – By Dr John Mandrola

Chapter 2: On the meaning of a coronary blockage – By Dr John Mandrola

Related/Original Articles:

ISCHEMIA Trial: Health-Status Outcomes with Initial Invasive vs. Conservative Care in Stable Coronary Disease

ISCHEMIA Trial: Initial Invasive vs. Conservative Strategy for Stable Coronary Disease

ISCHEMIA Trial: Health Status after Invasive or Conservative Care in Coronary and Advanced Kidney Disease

ISCHEMIA Trial: Management of Coronary Disease in Patients with Advanced Kidney Disease

Follow-up of the ISCHEMIA trial | Similar survival after invasive vs. conservative management of stable coronary disease.

ISCHEMIA Trial 2ry Analysis | Patients with CCD and daily/weekly angina seem to benefit most from complete revascularization

 

Meta-analysis | Even low levels of alcohol consumption may increase blood pressure

2 Aug, 2023 | 14:07h | UTC

Alcohol Intake and Blood Pressure Levels: A Dose-Response Meta-Analysis of Nonexperimental Cohort Studies – Hypertension

News Release: Routinely drinking alcohol may raise blood pressure even in adults without hypertension – AHA Newsroom

 

Evidence Review | AA and other 12-step programs outperform CBT for alcohol use disorder

2 Aug, 2023 | 14:05h | UTC

Alcohol dependence: evidence and experience on 12 steps to recovery – Evidently Cochrane

Original study: Alcoholics Anonymous and other 12‐step programs for alcohol use disorder – Cochrane Library

 

Guideline on multimodal rehabilitation for patients with post-intensive care syndrome

2 Aug, 2023 | 14:04h | UTC

Guideline on multimodal rehabilitation for patients with post-intensive care syndrome – Critical Care

 

Commentary from the author on Twitter

 

2023 ACR/EULAR classification criteria for calcium pyrophosphate deposition disease

2 Aug, 2023 | 14:02h | UTC

The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease – Arthritis & Rheumatology

Commentary: 2023 ACR/EULAR Criteria for Calcium Pyrophosphate Deposition Disease – RheumNow

 

BSH guideline for anticoagulant management of pregnant individuals with mechanical heart valves

2 Aug, 2023 | 14:01h | UTC

British Society for Haematology guideline for anticoagulant management of pregnant individuals with mechanical heart valves – British Journal of Haematology

 

RCT | Multiple sclerosis disease-modifying therapy continuation versus discontinuation in older individuals

2 Aug, 2023 | 14:00h | UTC

Risk of new disease activity in patients with multiple sclerosis who continue or discontinue disease-modifying therapies (DISCOMS): a multicentre, randomised, single-blind, phase 4, non-inferiority trial – The Lancet Neurology (link to abstract – $ for full-text)

Commentaries:

Study investigates risk when discontinuing therapy for MS patients over 55 – CU Anschutz Medical Campus

Discontinuing Multiple Sclerosis Therapies at Age 55 or Older – NEJM Journal Watch

 

Debate | Do all patients with asymptomatic severe aortic stenosis need valve replacement?

2 Aug, 2023 | 13:58h | UTC

Great debate: all patients with asymptomatic severe aortic stenosis need valve replacement – European Heart Journal

 

Commentary on Twitter

 

RCT | Atogepant outperforms placebo in reducing migraines over 12 weeks

2 Aug, 2023 | 13:56h | UTC

Atogepant for the preventive treatment of chronic migraine (PROGRESS): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

RCT | Lazertinib offers 20.6-month of median PFS in EGFR-mutated NSCLC vs 9.7 months with gefitinib

2 Aug, 2023 | 13:55h | UTC

Lazertinib Versus Gefitinib as First-Line Treatment in Patients With EGFR-Mutated Advanced Non–Small-Cell Lung Cancer: Results From LASER301 – Journal of Clinical Medicine

 

RCT | Camrelizumab-rivoceranib outperforms sorafenib as first-line therapy for unresectable HCC

2 Aug, 2023 | 13:53h | UTC

Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for unresectable hepatocellular carcinoma (CARES-310): a randomised, open-label, international phase 3 study – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Case Report | Post-myocardial infarction free-wall rupture: rapid diagnosis and management

2 Aug, 2023 | 13:52h | UTC

Post-Myocardial Infarction Free-Wall Rupture: Rapid Diagnosis and Management – JACC: Case Reports

 

Commentary on Twitter

 

M-A | High-volume disease, T stage 4 show largest docetaxel benefit in prostate cancer

2 Aug, 2023 | 13:51h | UTC

Which patients with metastatic hormone-sensitive prostate cancer benefit from docetaxel: a systematic review and meta-analysis of individual participant data from randomised trials – The Lancet Oncology

Commentaries:

Meta-analysis of the Addition of Docetaxel to ADT in Metastatic Hormone-Sensitive Prostate Cancer – The ASCO Post

Disease Volume and T Stage Affect Docetaxel/ADT Efficacy in Prostate Cancer – Cancer Network

 

Commentary on Twitter

 

Cohort Study | Depression at any life stage linked to increased dementia incidence

2 Aug, 2023 | 13:49h | UTC

Association of Early-, Middle-, and Late-Life Depression With Incident Dementia in a Danish Cohort – JAMA Neurology (link to abstract – $ for full-text)

Commentary: Depression Over Adulthood May Increase Risk of Dementia – Psychiatric News Alert

 

RCT | Maternal egg intake in early neonatal period does not impact infant egg allergy risk

2 Aug, 2023 | 13:47h | UTC

Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 

RCT | Baricitinib demonstrates efficacy in treatment-resistant juvenile idiopathic arthritis

2 Aug, 2023 | 13:45h | UTC

Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Platelet-rich plasma injections lack efficacy in 52-week ankle osteoarthritis study

2 Aug, 2023 | 13:43h | UTC

Platelet-Rich Plasma Injections for the Treatment of Ankle Osteoarthritis – The American Journal of Sports Medicine

 

RCT | Early vs. delayed intrauterine balloon tamponade: no difference in severe postpartum hemorrhage

2 Aug, 2023 | 13:42h | UTC

Efficacy of early intrauterine balloon tamponade for immediate postpartum hemorrhage after vaginal delivery: a randomized clinical trial – The American Journal of Obstetrics and Gynecology (link to abstract  – $ for full-text)

 

Consensus Paper | Diagnosis and management of infective endocarditis in adults

1 Aug, 2023 | 14:34h | UTC

Guidelines for Diagnosis and Management of Infective Endocarditis in Adults: A WikiGuidelines Group Consensus Statement – JAMA Network Open

 

Review | Futility in clinical trials

1 Aug, 2023 | 14:32h | UTC

Futility in Clinical Trials – JAMA (free for a limited period)

 

Study | AI use in lung cancer screening enhances prediction of lung cancer death, CVD death, and all-cause death

1 Aug, 2023 | 14:31h | UTC

AI Body Composition in Lung Cancer Screening: Added Value Beyond Lung Cancer Detection – Radiology (free for a limited period)

Commentary: Study: AI Assessment of Chest CT May Predict Multiple Mortality Risks – Diagnostic Imaging

 

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