All Posts
Review | Diagnosis and management of prediabetes
12 Apr, 2023 | 13:28h | UTCDiagnosis and Management of Prediabetes: A Review – JAMA (free for a limited period)
Editorial: Prediabetes Diagnosis and Management – JAMA (free for a limited period)
Video: Screening for Prediabetes – JAMA
Audio Clinical Review: Diagnosis and Management of Patients With Prediabetes – JAMA
RCT | Doxycycline postexposure prophylaxis effective in preventing gonorrhea, chlamydia, and syphilis in MSM
12 Apr, 2023 | 13:30h | UTCSummary: In this open-label, randomized study involving 501 men who have sex with men (MSM) and transgender women, researchers investigated the effectiveness of postexposure doxycycline in preventing bacterial sexually transmitted infections (STIs), specifically gonorrhea, chlamydia, and syphilis. Participants with a previous STI in the past year, either taking preexposure prophylaxis (PrEP) against HIV or living with HIV, were randomly assigned to receive 200 mg of doxycycline within 72 hours after condomless sex or standard care without doxycycline. STI testing was performed quarterly, with the primary end point being the incidence of at least one STI per follow-up quarter.
Results demonstrated a significant reduction in STI incidence in both the PrEP and persons living with HIV cohorts who received doxycycline. Overall, the combined incidence of these three STIs was lower by two thirds with doxycycline postexposure prophylaxis compared to standard care. The study also reported five grade 3 adverse events but no serious adverse events attributed to doxycycline. This finding supports the use of doxycycline postexposure prophylaxis among MSM with recent bacterial STIs.
Article: Postexposure Doxycycline to Prevent Bacterial Sexually Transmitted Infections – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Doxycycline after sex found to reduce STI incidence in gay men, transgender women – CIDRAP
Commentary on Twitter
In an open-label, randomized study involving men who have sex with men, doxycycline use after high-risk sexual exposure reduced the incidence of sexually transmitted infections (chlamydia, gonorrhea, and syphilis). https://t.co/tYOj8FLEy2 pic.twitter.com/bzNyvwzYS7
— NEJM (@NEJM) April 5, 2023
Cohort Study | Third trimester ultrasound reduces undiagnosed breech presentations
12 Apr, 2023 | 13:27h | UTCCommentary: Timely Ultrasound Can ID Undiagnosed Breech Presentations – HealthDay
M-A | Association of inhaled corticosteroids with all-cause mortality risk in patients with COPD
12 Apr, 2023 | 13:25h | UTCAssociation of Inhaled Corticosteroids With All-Cause Mortality Risk in Patients With COPD: A Meta-analysis of 60 Randomized Controlled Trials – Chest (link to abstract – $ for full-text)
Commentary on Twitter
ICS-based inhaled therapy of longer than 6 months associated with reduction in all-cause mortality risk in patients with #COPD in a meta-analysis of 60 RCTs. Read the full original research in the January issue: https://t.co/p2CwSu8aqb#journalCHEST #MedEd pic.twitter.com/0j24enQmX3
— CHEST® Journal (@journal_CHEST) January 20, 2023
Review | Revised definition of pulmonary hypertension and approach to management
12 Apr, 2023 | 13:22h | UTCRelated:
#ESCCongress | 2022 ESC/ERS Guidelines for the diagnosis and treatment of pulmonary hypertension.
Pulmonary hypertension: An update of Dx and Tx guidelines – Journal of Family Practice
The physiological basis of pulmonary arterial hypertension – European Respiratory Journal
Topic-Based, Recent Literature Review on Pulmonary Hypertension – Mayo Clinic Proceedings
Twenty‐four-hour ambulatory blood pressure profile in patients with reflex syncope vs. matched controls
12 Apr, 2023 | 13:21h | UTC
Cohort Study | Association of the AHA’s new “Life’s Essential 8” with all-cause and cardiovascular disease-specific mortality
12 Apr, 2023 | 13:20h | UTCCommentaries:
Related: Life’s Essential 8: Updating and enhancing the AHA construct of cardiovascular health.
SR | Experiences and perceptions of cash transfers for health
12 Apr, 2023 | 13:23h | UTCSummary: Experiences and perceptions of cash transfers for health – Cochrane Library
ASCO Policy Statement on biosimilar and interchangeable products in oncology
12 Apr, 2023 | 13:18h | UTCASCO Policy Statement on Biosimilar and Interchangeable Products in Oncology – JCO Oncology Practice
Low back pain of disc, sacroiliac joint, or facet joint origin: a diagnostic accuracy systematic review
12 Apr, 2023 | 13:17h | UTC
Guideline | Management of systemic lupus erythematosus
12 Apr, 2023 | 13:16h | UTC
Cohort Study | Major cardiovascular events after spontaneous intracerebral hemorrhage by hematoma location
12 Apr, 2023 | 13:13h | UTCInvited Commentary: Major Adverse Cardiovascular Events After Intracerebral Hemorrhage—It’s All About Location, Location, Location – JAMA Network Open
Cohort Study | Value of screening for the risk of sudden cardiac death in young competitive athletes
12 Apr, 2023 | 13:11h | UTC
Review | Inappropriate prescriptions of direct oral anticoagulants (DOACs) in hospitalized patients
12 Apr, 2023 | 13:14h | UTC
Single arm trial | Safety of metformin continuation in diabetic patients undergoing invasive coronary angiography
12 Apr, 2023 | 13:06h | UTC
Perspective | Proposal of a model of care for outpatient antimicrobial therapy for infective endocarditis
12 Apr, 2023 | 13:08h | UTCOutpatient Parenteral Antimicrobial Therapy for Infective Endocarditis—Model of Care – Antibiotics
Commentary on Twitter
?️⚡️ @antibioticsmdpi
Outpatient Parenteral Antimicrobial Therapy for Infective Endocarditis—Model of Care#IDTwitter #IEWikiguidelines https://t.co/uI88p1l7nR pic.twitter.com/2JiFTKR5fr— Antibiotic Steward Bassam Ghanem?? (@ABsteward) February 10, 2023
RCT | Effects of focal vs. extended irreversible electroporation ablation of localized prostate cancer
12 Apr, 2023 | 13:05h | UTCEffect of Focal vs Extended Irreversible Electroporation for the Ablation of Localized Low- or Intermediate-Risk Prostate Cancer on Early Oncological Control: A Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)
Commentary on Twitter
Irreversible electroporation (IRE) can provide promising oncological control as a focal therapy for patients with localized low-intermediate risk prostate cancer patients. https://t.co/lmYnYpSRmY
— JAMA Surgery (@JAMASurgery) February 1, 2023
Cluster RCT | Long-lasting insecticidal nets compared for malaria control
12 Apr, 2023 | 13:04h | UTCInvited Commentary: Getting ahead of insecticide-resistant malaria vector mosquitoes – The Lancet (free registration required)
M-A | Endovascular revascularization strategies for aortoiliac and femoropopliteal artery disease
12 Apr, 2023 | 13:01h | UTCCommentary: Endovascular Revascularization in Intermittent Claudication – American College of Cardiology
RCTs | Eczema Care Online behavioral interventions may support self-care for children and young people
12 Apr, 2023 | 13:02h | UTCEditorial: How to make Eczema Care Online freely available – The BMJ
News Release: New website helps improve eczema in children and young people – University of Southampton
SR | Remote ischemic preconditioning for vascular and endovascular surgical procedures
12 Apr, 2023 | 13:00h | UTC
Review | Diagnostic, structured classification and therapeutic approach in cystic pancreatic lesions
12 Apr, 2023 | 12:58h | UTCRelated:
Cystic pancreatic lesions: MR imaging findings and management.
Recommendations for the management of incidental pancreatic findings in adults.
Pancreatic cystic neoplasms: a review of current recommendations for surveillance and management
Management of Pancreatic Cystic Lesions
Consensus Recommendations: Diagnosis and Surveillance of Incidental Pancreatic Cystic Lesions
Review: Pancreatic Cystic Lesions
Guidelines on pancreatic cystic neoplasms
RCT | Low-dose olanzapine enhances appetite & weight gain in chemotherapy patients
11 Apr, 2023 | 14:41h | UTCRandomized Double-Blind Placebo-Controlled Study of Olanzapine for Chemotherapy-Related Anorexia in Patients With Locally Advanced or Metastatic Gastric, Hepatopancreaticobiliary, and Lung Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)
Commentaries:
Low-dose olanzapine improves appetite in chemotherapy patients – MDedge
Commentary on Twitter
This trial is as good as it gets ⭐️⭐️⭐️⭐️⭐️
✅Patient centered supportive care trial
✅Inexpensive medication
✅Conducted in a LMIC
✅Clinically relevant endpoint
✅ Randomized/double-blinded study
✅Potential to immediately change practicehttps://t.co/3nRrFJaS20Kudos!
— Manni Mohyuddin (@ManniMD1) March 29, 2023
Pharmacological treatments for low back pain in adults: an overview of Cochrane Reviews
11 Apr, 2023 | 14:39h | UTCRelated:
SR | Nonopioid pharmacological management of acute low back pain
M-A | Limited evidence for analgesic effectiveness in acute low back pain treatment
M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain
Guideline Interventions for the management of acute and chronic low back pain.
M-A: Little benefit from muscle relaxants for adults with non-specific low back pain.
RCT | Exploring the potential of peritumoral lidocaine infiltration to improve outcomes in early breast cancer
11 Apr, 2023 | 14:37h | UTCEffect of Peritumoral Infiltration of Local Anesthetic Before Surgery on Survival in Early Breast Cancer – Journal of Clinical Oncology (link to abstract – $ for full-text)