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RCT | Piperacillin-tazobactam better than cefoxitin in antimicrobial prophylaxis for open pancreatoduodenectomy
21 Apr, 2023 | 13:08h | UTCPiperacillin-Tazobactam Compared With Cefoxitin as Antimicrobial Prophylaxis for Pancreatoduodenectomy: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Informing a Rational Approach to Antimicrobial Prophylaxis in Open Pancreatoduodenectomy – JAMA (free for a limited period)
Commentary on Twitter
Study findings support the use of piperacillin-tazobactam as perioperative antimicrobial prophylaxis for open pancreatoduodenectomy. https://t.co/M9qAVrePRH pic.twitter.com/xq01qPTHQO
— JAMA (@JAMA_current) April 20, 2023
Study estimates poor diet causes 70% of diabetes cases globally
21 Apr, 2023 | 13:06h | UTCIncident type 2 diabetes attributable to suboptimal diet in 184 countries – Nature Medicine
News Release: Study links poor diet to 14 million cases of type 2 diabetes globally – Tufts University
Commentary on Twitter
An analysis in @NatureMedicine estimates that 70% of new global cases of type 2 diabetes are attributable to suboptimal intake of 11 dietary factors, with substantial differences in dietary risks across world regions and nations. https://t.co/MYoLRt3rhO pic.twitter.com/Pv7I6Mhvxu
— Nature Portfolio (@NaturePortfolio) April 19, 2023
RCT | Pregnant individuals benefit from brief interpersonal psychotherapy for depression
21 Apr, 2023 | 13:05h | UTCCommentary: Interpersonal Psychotherapy Reduces Depression Symptoms of Pregnant Women – HCP Live
Commentary on Twitter
A randomized clinical trial of prenatal interpersonal psychotherapy showed rapid decreases in depression. Depression in the intervention group dropped from 37% before intervention to 6% after (vs. 26% in control group). https://t.co/rJADZZkfER
— JAMA Psychiatry (@JAMAPsych) April 19, 2023
M-A | Electroconvulsive therapy may be superior to ketamine for patients with major depressive episode
21 Apr, 2023 | 13:03h | UTCKetamine vs Electroconvulsive Therapy for Major Depressive Episode: A Systematic Review and Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries:
Electroconvulsive Therapy Bests Ketamine in Treating Major Depressive Episodes – HCP Live
Review | The importance of using placebo controls in nonpharmacological randomized trials
21 Apr, 2023 | 13:02h | UTCThe importance of using placebo controls in nonpharmacological randomised trials – Pain
RCT | Efficacy and safety of ritlecitinib in adults and adolescents with alopecia areata
21 Apr, 2023 | 13:00h | UTCEfficacy and safety of ritlecitinib in adults and adolescents with alopecia areata: a randomised, double-blind, multicentre, phase 2b–3 trial – The Lancet (link to abstract – $ for full-text)
News Release: Progress in search for alopecia areata treatment for adolescents – Yale News
Commentary on Twitter
Ritlecitinib might be a treatment option for alopecia areata in patients aged 12 years and older, suggests a new study: https://t.co/jKUxEbo4AZ
Below, a graphical abstract ? pic.twitter.com/JIJtTGHeE4
— The Lancet (@TheLancet) April 17, 2023
M-A | Adverse events related to tirzepatide (a dual GIP/GLP-1 receptor agonist)
21 Apr, 2023 | 12:59h | UTCAdverse Events Related to Tirzepatide – Journal of the Endocrine Society
Related:
Tirzepatide Once Weekly for the Treatment of Obesity – New England Journal of Medicine
Tirzepatide cardiovascular event risk assessment: a pre-specified meta-analysis – Nature Medicine
Effect of Subcutaneous Tirzepatide vs Placebo Added to Titrated Insulin Glargine on Glycemic Control in Patients With Type 2 Diabetes: The SURPASS-5 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Tirzepatide versus insulin glargine in type 2 diabetes and increased cardiovascular risk (SURPASS-4): a randomised, open-label, parallel-group, multicentre, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Once-weekly tirzepatide versus once-daily insulin degludec as add-on to metformin with or without SGLT2 inhibitors in patients with type 2 diabetes (SURPASS-3): a randomised, open-label, parallel-group, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Efficacy and safety of a novel dual GIP and GLP-1 receptor agonist tirzepatide in patients with type 2 diabetes (SURPASS-1): a double-blind, randomised, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Tirzepatide versus Semaglutide Once Weekly in Patients with Type 2 Diabetes – New England Journal of Medicine (link to abstract – $ for full-text)
ACSM expert consensus statement on exertional heat illness: recognition, management, and return to activity
19 Apr, 2023 | 13:27h | UTCRelated:
Exertional heat stroke: pathophysiology and risk factors – BMJ Medicine
Classic and exertional heatstroke – Nature Reviews Disease Primers
Treatment and Prevention of Heat-Related Illness – New England Journal of Medicine
Study shows that parathyroidectomy in adults with primary hyperparathyroidism probably has no effect on kidney function
21 Apr, 2023 | 12:57h | UTCEstimated Effect of Parathyroidectomy on Long-Term Kidney Function in Adults With Primary Hyperparathyroidism – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary on Twitter
New: #parathyroidectomy had no effect on long term #KidneyFunction in older adults w/ primary #hyperparathyroidism, but may preserve function in patients under 60. https://t.co/B456rPwGem pic.twitter.com/V8hLmrYiUX
— Annals of Int Med (@AnnalsofIM) April 17, 2023
Joint statement for assessing and managing high blood pressure in children and adolescents
19 Apr, 2023 | 13:26h | UTCChapter 1: How to correctly measure blood pressure in children and adolescents – Frontiers in Pediatrics
Chapter 2: How to manage high blood pressure in children and adolescents – Frontiers in Pediatrics
Related:
AHA Scientific Statement | Pediatric primary hypertension: An underrecognized condition
AHA Scientific Statement: Ambulatory blood pressure monitoring in children and adolescents.
M-A | Glucocorticoids may increase mortality for hospitalized Covid-19 patients not receiving oxygen
19 Apr, 2023 | 13:24h | UTCMeta-Analysis of Glucocorticoids for Covid-19 Patients Not Receiving Oxygen – NEJM Evidence
Commentary on Twitter (thread – click for more)
4/
? IMPLICATIONS#Glucocorticoids are a two-edged sword in COVID-19 treatment ?️
? Life-saving for patients receiving #oxygen☠️ Harmful for patients not on oxygen
— San Raffaele Anesthesia and Intensive Care (@SRAnesthesiaICU) April 18, 2023
RCT | Prophylactic tranexamic acid in cesarean delivery did not significantly reduce maternal death or transfusion risk
19 Apr, 2023 | 13:22h | UTCTranexamic Acid to Prevent Obstetrical Hemorrhage after Cesarean Delivery – New England Journal of Medicine (link to abstract – $ for full-text)
News Release: Tranexamic acid does not appear to prevent maternal hemorrhage after cesarean delivery – National Institutes of Health
Commentary on Twitter
In a placebo-controlled trial involving patients undergoing cesarean delivery, prophylactic use of tranexamic acid did not lead to a significantly lower risk of a composite outcome of maternal death or blood transfusion. https://t.co/iB3axZiVqw pic.twitter.com/RDFUsspIr0
— NEJM (@NEJM) April 12, 2023
RCT | Blood donor’s sex does not impact transfusion recipients’ survival
19 Apr, 2023 | 13:20h | UTCEffect of Donor Sex on Recipient Mortality in Transfusion – New England Journal of Medicine (link to abstract – $ for full-text)
News release: Sex of blood donor has no effect on recipient survival – Ottawa Hospital
Commentary on Twitter
Observational data are conflicting about whether donor sex influences mortality among transfusion recipients. In a multicenter trial in Canada involving 8719 patients, mortality was not influenced by blood-donor sex. https://t.co/54GKPXSXES pic.twitter.com/uYw1KT15py
— NEJM (@NEJM) April 12, 2023
Perspective | Here’s a new data point for cancer patients to consider: ‘time toxicity’
19 Apr, 2023 | 13:18h | UTCHere’s a new data point for cancer patients to consider: ‘time toxicity’ – STAT
Ischemia with nonobstructive coronary artery disease: concept, assessment, and management
19 Apr, 2023 | 13:17h | UTCRelated:
Review: Myocardial infarction with non-obstructive coronary artery disease.
MINOCA from A to Z – American College of Cardiology
M-A | Test characteristics of ultrasound for the diagnosis of peritonsillar abscess
19 Apr, 2023 | 13:15h | UTCCommentary: How Good is Ultrasound at Diagnosing PTA? – RebelEM
Global Survey | Incidence, management and prognosis of esophageal fistula after atrial fibrillation catheter ablation
19 Apr, 2023 | 13:14h | UTCCommentary: Esophageal Fistula Still a Rare but Deadly Complication of AF Ablation: POTTER-AF – TCTMD
Commentary from the author on Twitter
?The POTTER-AF study
➡️published #EHJ online
➡️138 oesophageal fistulas
➡️incidence 0,025% overall, ?RF 0.038%, ❄️CRYO 0.0015%
☠️Mortality: 90% if treated conservative!
?V. Schmidt, @KeelaniAhmad @ChristianHeeger@AGEP_DGK @ESC_Journals #UKSHhttps://t.co/jTmC36wlYQ #EPeeps pic.twitter.com/3lntY6lR6H— Roland Tilz (@RolandTilz) April 16, 2023
SR | Opioids for procedural pain in neonates
19 Apr, 2023 | 13:11h | UTCOpioids for procedural pain in neonates – Cochrane Library
Guideline | Management of psychiatric disorders in patients with hepatic and gastrointestinal diseases
19 Apr, 2023 | 13:07h | UTC
RCT | Small benefit from pembrolizumab + gemcitabine/cisplatin vs. gemcitabine/cisplatin alone in advanced biliary tract cancer
19 Apr, 2023 | 13:10h | UTCPembrolizumab in combination with gemcitabine and cisplatin compared with gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter
New @TheLancet – Kelley et al – Pembrolizumab plus gemcitabine and cisplatin vs gemcitabine and cisplatin alone for patients with advanced biliary tract cancer (KEYNOTE-966)https://t.co/ZbdRQwzSuW#gitwitter #onctwitter pic.twitter.com/PwoNAduQxK
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) April 18, 2023
Study suggests that routine axillary scanning in diagnostic breast ultrasound has limited impact on cancer detection
19 Apr, 2023 | 13:06h | UTCTo scan or not to scan: effect of scanning the axilla of all patients undergoing diagnostic breast ultrasound – Clinical Imaging (link to abstract – $ for full-text)
Commentary: Is scanning the axilla during diagnostic breast ultrasound necessary? – Health Imaging
Opinion | Universal masking in health care settings: a pandemic strategy whose time has come and gone, for now
18 Apr, 2023 | 13:37h | UTC
Opinion | In-person schooling is essential even during periods of high transmission of COVID-19
18 Apr, 2023 | 13:36h | UTC
Comprehensive clinical practice guidelines for the management of psychiatric emergencies
18 Apr, 2023 | 13:34h | UTCClinical Practice Guidelines for Management of Suicidal Behaviour
Clinical Practice Guidelines for Assessment and Management of Aggressive and Assaultive Behaviour
Clinical Practice Guidelines on Breaking Bad News
Clinical Practice Guidelines for the Use of Electroconvulsive Therapy
Clinical Practice Guidelines for the Use of Transcranial Direct Current Stimulation in Psychiatry
Cluster RCT | Salt substitute outperforms salt restriction in lowering blood pressure in older patients
18 Apr, 2023 | 13:30h | UTCSalt substitution and salt-supply restriction for lowering blood pressure in elderly care facilities: a cluster-randomized trial – Nature Medicine (if the link is paywalled, try this one)
Commentary: Exploring effectiveness of salt substitutes in elderly care facilities – Medical Xpress
Related:
Salt substitutes vs. regular salt: a quick look.
Effects of salt substitutes on clinical outcomes: a systematic review and meta-analysis – Heart (link to abstract – $ for full-text)
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
Potassium Enriched Salt Substitution Could Prevent a Large Number of Cardiovascular Deaths
Commentary on Twitter
In a cluster-randomized trial in 48 residential elderly care facilities in China, a low-sodium salt substitute instead of regular salt decreased blood pressure and cardiovascular events, while restricting salt consumption did not show beneficial effects https://t.co/Zp0fWH0aA2
— Nature Medicine (@NatureMedicine) April 13, 2023