All Posts
M-A | Quality of life after risk-reducing surgery for breast and ovarian cancer prevention
9 May, 2023 | 14:21h | UTC
M-A | Identifying the optimal therapeutics for patients with hormone receptor-positive, HER2-positive advanced breast cancer
9 May, 2023 | 14:24h | UTC
Review | Challenges in cardiology: diagnosis of native and prosthetic valve endocarditis
9 May, 2023 | 14:19h | UTCSee all articles in the series here
Review | Causes of sudden death
9 May, 2023 | 14:16h | UTCCauses of sudden death – European Heart Journal Supplements
See all articles in the series here
Review | DOACs and rheumatic valvulopathy: always a red light?
9 May, 2023 | 14:15h | UTCDOACs and rheumatic valvulopathy: always a red light? – European Heart Journal Supplements
See all articles in the series here
WHO declares end to COVID-19 global health emergency
8 May, 2023 | 13:26h | UTCWHO Declares End to COVID-19 Global Health Emergency – Health Policy Watch
2023 updated AGS Beers Criteria for potentially inappropriate medication use in older adults
8 May, 2023 | 13:25h | UTC
Review | Deprescribing considerations for older people in general practice
8 May, 2023 | 13:23h | UTCRelated:
RCT | A deprescribing intervention reduced medication burden among older adults in post-acute care
Deprescribing proton pump inhibitors – Australian Journal of General Practice
Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports
Deprescribing in Palliative Cancer Care – Life
Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360
Polypharmacy Management in Older Patients – Mayo Clinic Proceedings
Eliminating Medication Overload: A National Action Plan – Lown Institute
Common ED Medication Errors: Polypharmacy – emDocs
Current and future perspectives on the management of polypharmacy – BMC Family Practice
Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international
Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety
‘Too greedy’: mass walkout at global science journal over ‘unethical’ fees
8 May, 2023 | 13:19h | UTC‘Too greedy’: mass walkout at global science journal over ‘unethical’ fees – The Guardian
Consensus Paper | Strategies to prevent surgical site infections in acute-care hospitals
8 May, 2023 | 13:21h | UTCNews Release: New guidance: antibiotics should be halted upon closure of incisions – Society for Healthcare Epidemiology of America
Commentary: New guidance calls for stopping antibiotic prophylaxis immediately after surgery – CIDRAP
Related: Consensus Paper | Strategies to prevent Clostridioides difficile infections in acute-care hospitals
Viewpoint | Essential electronic health record reforms for this decade
8 May, 2023 | 13:18h | UTCEssential Electronic Health Record Reforms for This Decade – JAMA
Commentary on Twitter
#Viewpoint: suggestions to reform electronic health records (EHRs), including use of unique personal safety identifiers, inclusion of patient-entered information into the EHR, and reinvention of the clinical note. https://t.co/6mMlC49pwm pic.twitter.com/rcucxX3xzz
— JAMA (@JAMA_current) May 4, 2023
M-A | Lower vs higher fluid volumes in sepsis: no significant impact on mortality or serious adverse events
8 May, 2023 | 13:16h | UTC
AACC Guidance document on the clinical use of procalcitonin
8 May, 2023 | 13:12h | UTCAACC Guidance Document on the Clinical Use of Procalcitonin – The Journal of Applied Laboratory Medicine (free for a limited period)
Commentary on Twitter
Special Report: AACC Guidance Document on the Clinical Use of Procalcitonin https://t.co/RAjvJF6Q0e #LabMed #PathTwitter #Pathology #ClinChem pic.twitter.com/oKMnlhl8a0
— JournApplLabMed (@JALM_AACC) May 4, 2023
Cohort Study | Autoimmune disorders’ incidence, prevalence & co-occurrence by age, sex, and socioeconomic status
8 May, 2023 | 13:14h | UTCIncidence, prevalence, and co-occurrence of autoimmune disorders over time and by age, sex, and socioeconomic status: a population-based cohort study of 22 million individuals in the UK – The Lancet (free for a limited period)
Commentary from the author on Twitter (thread – click for more)
Our latest research is out in @TheLancet today
We sought to answer:
1. Are autoimmune diseases on the rise as has been suggested?
2. Can we identify clues as to their causes (genetic or environmental)?
3. Do different autoimmune diseases cluster together & what might this mean? pic.twitter.com/noCpPpo8FU— Nathalie Conrad (@nathalie_conrad) May 6, 2023
New CV POCUS workbook addresses current value and vision for future use
8 May, 2023 | 13:10h | UTC
Brief review | What’s new in therapeutic drug monitoring of antimicrobials?
8 May, 2023 | 13:08h | UTCWhat’s new in therapeutic drug monitoring of antimicrobials? – Intensive Care Medicine
Commentary on Twitter
TDM of antimicrobials in #ICU
?life-saving drugs, difficult pharmacology
?TDM: why do we need it?
?uncertainties
concentrations to be targeted/where
adjusting dose if out of range
steady state: prerequisite?
outcomes when studying TDM#FOAMcc
?️ https://t.co/0DiDW7ONvV pic.twitter.com/0SQH0DR7Z0— Intensive Care Medicine (@yourICM) May 3, 2023
Brief Review | More than patient benefit: taking a broader view of ICU admission decisions
8 May, 2023 | 13:07h | UTCMore than patient benefit: taking a broader view of ICU admission decisions – Intensive Care Medicine (if the link is paywalled, try this one)
Metformin: update on mechanisms of action and repurposing potential
8 May, 2023 | 13:05h | UTCMetformin: update on mechanisms of action and repurposing potential – Nature Reviews Endocrinology (if the link is paywalled, try this one in PMC)
Commentary on Twitter
New content online: Metformin: update on mechanisms of action and repurposing potential https://t.co/30uhafcKPu pic.twitter.com/kfyzDEUlBg
— Nature Reviews Endocrinology (@NatureRevEndo) May 2, 2023
RCT | Tislelizumab plus chemotherapy vs placebo plus chemotherapy for advanced esophageal squamous cell carcinoma
8 May, 2023 | 13:04h | UTCTislelizumab plus chemotherapy versus placebo plus chemotherapy as first-line treatment for advanced or metastatic oesophageal squamous cell carcinoma (RATIONALE-306): a global, randomised, placebo-controlled, phase 3 study – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
NOW OF: Interim analysis of the RATIONALE-306 trial of 1st-line tislelizumab + chemo vs placebo + chemo in adv or metastatic oesophageal squamous cell carcinoma—median OS 17·2 mo (95% CI 15·8–20·1) vs 10·6 mo (9·3–12·1; HR 0·66, 95% CI 0·54–0·80; p<0·0001)https://t.co/25lyg2Ef0o pic.twitter.com/vizCPVd8bj
— The Lancet Oncology (@TheLancetOncol) April 18, 2023
RCT | Long-term survival benefit with abiraterone plus ADT in metastatic PC, but no advantage with enzalutamide association
8 May, 2023 | 13:02h | UTC
Commentary on Twitter
NEW: Final results from two randomised ph 3 trials of the STAMPEDE platform protocol suggest that enzalutamide and abiraterone should not be combined for patients with prostate cancer starting long-term androgen deprivation therapy. #pcsmhttps://t.co/P1uqzE4Wsv pic.twitter.com/l8U7DQZIoe
— The Lancet Oncology (@TheLancetOncol) May 4, 2023
RCT | Ibrutinib plus rituximab improve CLL PFS vs chemoimmunotherapy, but increased unexplained/cardiac deaths
8 May, 2023 | 13:00h | UTC
Brief Review | Is combination pharmacotherapy effective for patients with acute depression?
8 May, 2023 | 12:57h | UTC
Cohort Study | Ibrutinib is associated with increased cardiovascular events and major bleeding in older CLL patients
8 May, 2023 | 12:59h | UTC
Commentary on Twitter
#Ibrutinib was associated with an increased risk of stroke, #AFib and bleeding, especially in older patients. The risk of major bleeding is higher than previously reported. https://t.co/dhP7Kwogdt#JACCCardioOnc #CardioOnc #geriheme #lymsm #leusm #CLL @AkivaDiamond @paolocaimiMD pic.twitter.com/MvzCh1i6LU
— JACC Journals (@JACCJournals) May 4, 2023
Evidence-based recommendations for the dietary management of diabetes
8 May, 2023 | 12:56h | UTCEvidence-based European recommendations for the dietary management of diabetes – Diabetologia (if the link is paywalled, try this one)
Cohort Study | ICU admission for solid cancer patients treated with immune checkpoint inhibitors
8 May, 2023 | 12:53h | UTC