All Posts

RCT | Personalized eHealth program hastens return to normal activity post major abdominal surgery

7 Jul, 2023 | 16:20h | UTC

Personalised electronic health programme for recovery after major abdominal surgery: a multicentre, single-blind, randomised, placebo-controlled trial – The Lancet Digital Health

Invited Commentary: Individualising the recovery process through eHealth – The Lancet Digital Health

News Release: eHealth app helps patients recover from major abdominal operations 30% faster – Amsterdam University Medical Centers/News Medical

 

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Consensus Paper | Adult cardiac surgery-associated acute kidney injury

7 Jul, 2023 | 16:18h | UTC

Adult Cardiac Surgery-Associated Acute Kidney Injury: Joint Consensus Report – Journal of Cardiothoracic and Vascular Anesthesia

 

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Consensus Paper | Methotrexate for inflammatory skin disease in pediatric patients

7 Jul, 2023 | 16:16h | UTC

Methotrexate for inflammatory skin disease in pediatric patients: Consensus treatment guidelines – Pediatrics Dermatology

 

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Consensus Paper | The place of new antibiotics for Gram-negative bacterial infections in intensive care

7 Jul, 2023 | 16:15h | UTC

The place of new antibiotics for Gram-negative bacterial infections in intensive care: report of a consensus conference – Annals of Intensive Care

 

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Single-arm study | Pirtobrutinib exhibits efficacy in CLL patients after failure of covalent BTK inhibitor treatment

7 Jul, 2023 | 16:14h | UTC

Pirtobrutinib after a Covalent BTK Inhibitor in Chronic Lymphocytic Leukemia – New England Journal of Medicine (link to abstract – $ for full-text)

News release from the manufacturer: New England Journal of Medicine Publishes BRUIN Phase 1/2 Trial Data for Pirtobrutinib in BTK Inhibitor Pre-Treated Adult Patients with Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma – Lilly

 

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Review | Cardiovascular outcomes in patients with diabetes and kidney disease

7 Jul, 2023 | 16:13h | UTC

Cardiovascular Outcomes in Patients With Diabetes and Kidney Disease: JACC Review Topic of the Week – Journal of the American College of Cardiology

 

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Cohort Study | Incidence and risk factors of postoperative urinary retention after inguinal hernia repair

7 Jul, 2023 | 16:11h | UTC

Global Incidence and Risk Factors Associated With Postoperative Urinary Retention Following Elective Inguinal Hernia Repair: The Retention of Urine After Inguinal Hernia Elective Repair (RETAINER I) Study – JAMA Surgery (link to abstract – $ for full-text)

 

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Review | Acute-on-chronic liver failure

7 Jul, 2023 | 16:09h | UTC

Acute-on-chronic liver failure: far to go—a review – Critical Care

Related:

EASL Clinical Practice Guidelines on acute-on-chronic liver failure – Journal of Hepatology

Guidelines for the management of adult acute and acute-on-chronic liver failure in the ICU

 

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Review | Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome

7 Jul, 2023 | 16:08h | UTC

Diabetes detection in women with gestational diabetes and polycystic ovarian syndrome – The BMJ

 

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RCT | Brachytherapy alone sufficient for intermediate-risk prostate cancer, no FFP improvement with additional EBRT

7 Jul, 2023 | 16:06h | UTC

Effect of Brachytherapy With External Beam Radiation Therapy Versus Brachytherapy Alone for Intermediate-Risk Prostate Cancer: NRG Oncology RTOG 0232 Randomized Clinical Trial – Journal of Clinical Oncology (link to abstract – $ for full-text)

News Release: Addition of EBRT to brachytherapy did not improve outcomes for men with intermediate-risk prostate cancer, brachytherapy alone remains standard of care – NRG Oncology

 

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Review | Surgical treatment options for male stress urinary incontinence

7 Jul, 2023 | 16:03h | UTC

A narrative review on surgical treatment options for male stress urinary incontinence – Translational Andrology and Urology

 

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Review | Hypereosinophilic syndrome (HES) and eosinophilic granulomatosis with polyangiitis (EGPA): two sides of the same coin

7 Jul, 2023 | 16:01h | UTC

HES and EGPA: Two Sides of the Same Coin – Mayo Clinic Proceedings

 

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ASA Consensus Guidance | Preoperative management of patients on GLP-1 agonists

5 Jul, 2023 | 01:17h | UTC

American Society of Anesthesiologists Consensus-Based Guidance on Preoperative Management of Patients (Adults and Children) on Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists – American Society of Anesthesiologists

Commentary: Anesthesiologists Say Ozempic, Wegovy Should Be Halted Prior to Surgery – HealthDay

 

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RCT | Opioids not more effective than placebo for acute low back and neck pain

5 Jul, 2023 | 01:15h | UTC

Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

News Releases:

Opioids no more effective than placebo for acute back and neck pain – University of Sidney

Opioid pain relievers do not reduce acute lower back and neck pain, study suggests – The Lancet

Commentary from the authors: Opioids don’t relieve acute low back or neck pain – and can result in worse pain, new study finds – The Conversation

 

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RCT | Transcranial direct current stimulation fails to outperform sham in major depressive disorder treatment

5 Jul, 2023 | 01:12h | UTC

Transcranial direct current stimulation as an additional treatment to selective serotonin reuptake inhibitors in adults with major depressive disorder in Germany (DepressionDC): a triple-blind, randomised, sham-controlled, multicentre trial – The Lancet (link to abstract – $ for full-text)

 

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RCT | No statistically significant impact of vitamin D on major cardiovascular events

5 Jul, 2023 | 01:11h | UTC

Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial – The BMJ

Related:

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

 

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RCT | Lower rates of treatment failure with standard-course vs. short-course therapy in pediatric UTIs

5 Jul, 2023 | 01:09h | UTC

Short-Course Therapy for Urinary Tract Infections in Children: The SCOUT Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)

See also: Visual Abstract

Commentary: Treatment Failure Down With Standard-Course Therapy in Pediatric UTI – HealthDay

 

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Review | Pathogenesis and management of abdominal aortic aneurysm

5 Jul, 2023 | 01:07h | UTC

Pathogenesis and management of abdominal aortic aneurysm – European Heart Journal

See also: Visual Abstract

 

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RCT | Effect of mifepristone vs. placebo for treatment of adenomyosis with pain symptoms

5 Jul, 2023 | 01:06h | UTC

Effect of Mifepristone vs Placebo for Treatment of Adenomyosis With Pain Symptoms: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 

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GRADE guidance 36: updates to GRADE’s approach to addressing inconsistency

5 Jul, 2023 | 01:05h | UTC

GRADE guidance 36: updates to GRADE’s approach to addressing inconsistency – Journal of Clinical Epidemiology

 

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SR | Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis

5 Jul, 2023 | 01:04h | UTC

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis – Cochrane Library

 

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RCT | FOLFOXIRI-Bevacizumab shows promise as first-line treatment in unresectable colorectal cancer metastases

5 Jul, 2023 | 01:02h | UTC

First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group – The Lancet Oncology (link to abstract – $ for full-tetxt)

 

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M-A | Family screening for bicuspid aortic valve and aortic dilatation

5 Jul, 2023 | 01:01h | UTC

Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis – European Heart Journal

 

Commentary on Twitter

Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis https://t.co/8rc4Uysf5o @escardio #EHJ #ESCYoung pic.twitter.com/p4XRzb3mzb

— European Society of Cardiology Journals (@ESC_Journals) June 15, 2023

 

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Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management

5 Jul, 2023 | 01:00h | UTC

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management – American Journal of Hematology

 

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2023 ESH Guidelines for the management of arterial hypertension

3 Jul, 2023 | 14:34h | UTC

2023 ESH Guidelines for the management of arterial hypertension The Task Force for the management of arterial hypertension of the European Society of Hypertension Endorsed by the European Renal Association (ERA) and the International Society of Hypertension (ISH) – Journal of Hypertension

 

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