All Posts
Perspective | Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?
24 Jul, 2023 | 13:12h | UTCMedicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? – Nature
Related: Dozens of recent clinical trials may contain wrong or falsified data (free study by John Carlisle)
Commentary on Twitter
.@Nature reports on the investigations that suggest that, in some fields, at least one-quarter of clinical trials might be problematic or even entirely made up. The researchers behind these investigations are calling for stronger scrutiny. https://t.co/uztDC6JwbH
— Nature Portfolio (@NaturePortfolio) July 22, 2023
RCT | Planned delivery from 34 weeks’ gestation effectively reduces pre-eclampsia related morbidity and mortality in LMICs
24 Jul, 2023 | 13:10h | UTCRelated:
RCT | Planned delivery for pre-eclampsia between 34 and 37 weeks of gestation
M-A | Planned delivery or expectant management in preeclampsia.
Randomized Trial: Planned Early Delivery vs. Expectant Management for Late Preterm Pre-eclampsia
Consensus Paper | De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and PCI
24 Jul, 2023 | 13:08h | UTCDe-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a Consensus Statement from an international expert panel on coronary thrombosis – Nature Reviews Cardiology (if the link is paywalled, try this one)
Consensus Paper | Lung ultrasound in acute and chronic heart failure
24 Jul, 2023 | 13:06h | UTC
Review | Oxytocin: physiology, pharmacology, and clinical application for labor management
24 Jul, 2023 | 13:04h | UTCOxytocin: physiology, pharmacology, and clinical application for labor management – American Journal of Obstetrics & Gynecology (free for a limited period)
Cohort Study | Increased risk of depression and suicide among people with HIV, especially in the first two years post-diagnosis
24 Jul, 2023 | 13:01h | UTC
Commentary on Twitter
Risk of Depression in People With HIV: A nationwide population-based matched cohort study
✅ Just Accepted
? Freely Availablehttps://t.co/nyrzPqRRqw— Clinical Infectious Diseases (@CIDJournal) July 22, 2023
Review | Radiomics-based fertility-sparing treatment in endometrial carcinoma
24 Jul, 2023 | 13:00h | UTC
Systematic Review | Dual therapy of Rifaximin and lactulose potentially reduces risk in hepatic encephalopathy
24 Jul, 2023 | 12:57h | UTC
Systematic Review | Insufficient evidence for ACEi/ARB’s impact on early non-diabetic CKD
24 Jul, 2023 | 12:56h | UTC
Review | Research on prescribing cascades
24 Jul, 2023 | 12:53h | UTCResearch on prescribing cascades: a scoping review – Frontiers in Pharmacology
Pooled Analysis | High disease prevalence linked to increased sensitivity, decreased specificity
24 Jul, 2023 | 12:51h | UTC
RCT | Long-term Doxycycline for COPD does not reduce exacerbations, except possibly in severe cases or with low eosinophils
24 Jul, 2023 | 12:50h | UTCA Double-Blind, Randomised, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable COPD – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)
RCT | Combined pre-operative olanzapine regimen lowers postoperative nausea in high-risk cancer patients
24 Jul, 2023 | 12:49h | UTC
Consensus Paper | Pre and post hair transplantation care
24 Jul, 2023 | 12:46h | UTC
Global perspectives on heart disease rehabilitation and secondary prevention
24 Jul, 2023 | 12:45h | UTC
M-A | Exposure to smoke, overcrowding, poor living conditions, and contact with TB cases identified as risk conditions for pediatric TB
24 Jul, 2023 | 12:43h | UTC
RCT | Online emotion regulation therapy yields significant reduction in adolescent self-injury
24 Jul, 2023 | 12:39h | UTCSee also: Visual Abstract
News Release: Internet-based therapy effective against self-harm in adolescents – Karolinska Institutes
2023 AHA/ACC Guideline for chronic coronary disease – B-blockers downgraded in patients without recent MI or low ejection fraction
21 Jul, 2023 | 13:52h | UTCKey Perspectives: 2023 Multisociety Guideline for Managing Chronic Coronary Disease – American College of Cardiology
Top things to know: 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease – American Heart Association
News Releases:
Commentary: New Chronic Heart Disease Guidelines Update Roles of GDMT, Imaging, and Revascularization – TCTMD
Commentary on Twitter with key points (thread – click for more)
?2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients w/ Chronic Coronary Disease aims to provide recommendations for diagnostic evaluation, symptom relief, improvement in QoL & reduction of future #ASCVD-related events & #heartfailure in patients w/ CCD.
— American College of Cardiology (@ACCinTouch) July 20, 2023
Guideline | Laboratory analysis in the diagnosis and management of diabetes mellitus
21 Jul, 2023 | 13:50h | UTCExecutive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care
Guideline Synopsis | Diagnosis and management of priapism
21 Jul, 2023 | 13:47h | UTCDiagnosis and Management of Priapism – JAMA (free for a limited period)
Original Guideline: The Diagnosis and Management of Recurrent Ischemic Priapism, Priapism in Sickle Cell Patients, and Non-Ischemic Priapism: An AUA/SMSNA Guideline – Journal of Urology
Cohort Study | ‘Weekend Warrior’ exercise pattern is associated with similar CVD benefits to regular activity
21 Jul, 2023 | 13:46h | UTCAccelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease – JAMA (free for a limited period)
Commentaries:
Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19
21 Jul, 2023 | 13:43h | UTC
Commentary from the author on Twitter (thread – click for more)
Our correspondence is out in @njem written w @VPrasadMDMPH & Ram Duriseti
We show v strong evidence of healthy vaccinee bias in an Israeli study of Pfizer booster vs covid death, which wasn't disclosed
Could explain ALL reported benefit of the booster?https://t.co/F3WeafvUnw pic.twitter.com/b29YQ0lblh
— Tracy Høeg, MD, PhD (@TracyBethHoeg) July 20, 2023
RCT | MIND diet, a hybrid of Mediterranean and DASH, shows no superiority in preventing cognitive decline
21 Jul, 2023 | 13:38h | UTCTrial of the MIND Diet for Prevention of Cognitive Decline in Older Persons – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Commentary on Twitter
Original Article: Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons https://t.co/ED5Rd6oCTf #AAIC23
— NEJM (@NEJM) July 19, 2023
RCT | Half-dose Tenecteplase + later PCI if indicated seems to be viable option in older individuals when timely PCI is unavailable
21 Jul, 2023 | 13:36h | UTCHalf-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction in STREAM-2: A Randomized, Open-Label Trial – Circulation (link to abstract – $ for full-text)
Commentary on Twitter
In the #STREAMI-2 trial of older adults w/ early-presenting STEMI, half-dose tenecteplase w/ PCI if indicated comparable to primary PCI for ECG/angio endpoints and 30d clinical efficacy but w/ higher risk of ICH @Cardio_KULeuven @CVC_UAlberta @BaineyKevin https://t.co/zFE6C1U98n pic.twitter.com/noWWhJ6y9h
— Circulation (@CircAHA) July 18, 2023
Phase 2 Trial | Maternal GBS6 vaccine shows promise in infant group B strep prevention
21 Jul, 2023 | 13:34h | UTCCommentary: Maternal strep B vaccine slashes risk of infection among infants – CIDRAP