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Perspective | Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed?

24 Jul, 2023 | 13:12h | UTC

Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? – Nature

Related: Dozens of recent clinical trials may contain wrong or falsified data (free study by John Carlisle)

 

Commentary on Twitter

 


RCT | Planned delivery from 34 weeks’ gestation effectively reduces pre-eclampsia related morbidity and mortality in LMICs

24 Jul, 2023 | 13:10h | UTC

Planned delivery or expectant management for late preterm pre-eclampsia in low-income and middle-income countries (CRADLE-4): a multicentre, open-label, randomised controlled trial – The Lancet

Related:

RCT | Planned delivery for pre-eclampsia between 34 and 37 weeks of gestation

M-A | Planned delivery or expectant management in preeclampsia.

Randomized Trial: Planned Early Delivery vs. Expectant Management for Late Preterm Pre-eclampsia

 


Consensus Paper | De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and PCI

24 Jul, 2023 | 13:08h | UTC

De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a Consensus Statement from an international expert panel on coronary thrombosis – Nature Reviews Cardiology (if the link is paywalled, try this one)

 


Consensus Paper | Lung ultrasound in acute and chronic heart failure

24 Jul, 2023 | 13:06h | UTC

Lung ultrasound in acute and chronic heart failure. A Clinical Consensus Statement of the European Association of Cardiovascular Imaging (EACVI) – European Heart Journal – Cardiovascular Imaging

 


Review | Oxytocin: physiology, pharmacology, and clinical application for labor management

24 Jul, 2023 | 13:04h | UTC

Oxytocin: physiology, pharmacology, and clinical application for labor management – American Journal of Obstetrics & Gynecology (free for a limited period)

 


Cohort Study | Increased risk of depression and suicide among people with HIV, especially in the first two years post-diagnosis

24 Jul, 2023 | 13:01h | UTC

Risk of Depression in People With HIV: A nationwide population-based matched cohort study – Clinical Infectious Diseases

 

Commentary on Twitter

 


Review | Radiomics-based fertility-sparing treatment in endometrial carcinoma

24 Jul, 2023 | 13:00h | UTC

Radiomics-based fertility-sparing treatment in endometrial carcinoma: a review – Insights into Imaging

 


Systematic Review | Dual therapy of Rifaximin and lactulose potentially reduces risk in hepatic encephalopathy

24 Jul, 2023 | 12:57h | UTC

Rifaximin for prevention and treatment of hepatic encephalopathy in people with cirrhosis – Cochrane Library

Summary: Rifaximin for prevention and treatment of hepatic encephalopathy in people with cirrhosis – Cochrane Library

 


Systematic Review | Insufficient evidence for ACEi/ARB’s impact on early non-diabetic CKD

24 Jul, 2023 | 12:56h | UTC

Angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non‐diabetic chronic kidney disease – Cochrane Library

Summary: Blood pressure lowering medication for adults with early stages of chronic kidney disease (without diabetes) – Cochrane Library

 


Review | Research on prescribing cascades

24 Jul, 2023 | 12:53h | UTC

Research on prescribing cascades: a scoping review – Frontiers in Pharmacology

 


Pooled Analysis | High disease prevalence linked to increased sensitivity, decreased specificity

24 Jul, 2023 | 12:51h | UTC

The association of sensitivity and specificity with disease prevalence: analysis of 6909 studies of diagnostic test accuracy – Canadian Medical Association Journal

 


RCT | Long-term Doxycycline for COPD does not reduce exacerbations, except possibly in severe cases or with low eosinophils

24 Jul, 2023 | 12:50h | UTC

A Double-Blind, Randomised, Placebo-controlled Trial of Long-Term Doxycycline Therapy on Exacerbation Rate in Patients with Stable COPD – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text)

 


RCT | Combined pre-operative olanzapine regimen lowers postoperative nausea in high-risk cancer patients

24 Jul, 2023 | 12:49h | UTC

Olanzapine as an add-on, pre-operative anti-emetic drug for postoperative nausea or vomiting: a randomised controlled trial – Anaesthesia

 


Consensus Paper | Pre and post hair transplantation care

24 Jul, 2023 | 12:46h | UTC

An international expert consensus statement focusing on pre and post hair transplantation care – Journal of Dermatological Treatment

 


Global perspectives on heart disease rehabilitation and secondary prevention

24 Jul, 2023 | 12:45h | UTC

Global perspectives on heart disease rehabilitation and secondary prevention: a scientific statement from the Association of Cardiovascular Nursing and Allied Professions, European Association of Preventive Cardiology, and International Council of Cardiovascular Prevention and Rehabilitation – European Heart Journal

 


M-A | Exposure to smoke, overcrowding, poor living conditions, and contact with TB cases identified as risk conditions for pediatric TB

24 Jul, 2023 | 12:43h | UTC

Risk factors for the development of tuberculosis among the pediatric population: a systematic review and meta-analysis – European Journal of Pediatrics

 


RCT | Online emotion regulation therapy yields significant reduction in adolescent self-injury

24 Jul, 2023 | 12:39h | UTC

Effect of Internet-Delivered Emotion Regulation Individual Therapy for Adolescents With Nonsuicidal Self-Injury Disorder: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

News Release: Internet-based therapy effective against self-harm in adolescents – Karolinska Institutes

 


2023 AHA/ACC Guideline for chronic coronary disease – B-blockers downgraded in patients without recent MI or low ejection fraction

21 Jul, 2023 | 13:52h | UTC

2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease: A Report of the American Heart Association/American College of Cardiology Joint Committee on Clinical Practice Guidelines – Journal of the American College of Cardiology

Key Perspectives: 2023 Multisociety Guideline for Managing Chronic Coronary Disease – American College of Cardiology

Top things to know: 2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients With Chronic Coronary Disease – American Heart Association

News Releases:

Symptom relief and healthy habits are top goals for treating chronic heart disease – American Heart Association

New ACC, AHA, Multi-Society Guideline Addresses Management of Chronic Coronary Disease – American College of Cardiology

Commentary: New Chronic Heart Disease Guidelines Update Roles of GDMT, Imaging, and Revascularization – TCTMD

 

Commentary on Twitter with key points (thread – click for more)

 


Guideline | Laboratory analysis in the diagnosis and management of diabetes mellitus

21 Jul, 2023 | 13:50h | UTC

Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

 


Guideline Synopsis | Diagnosis and management of priapism

21 Jul, 2023 | 13:47h | UTC

Diagnosis and Management of Priapism – JAMA (free for a limited period)

Original Guideline: The Diagnosis and Management of Recurrent Ischemic Priapism, Priapism in Sickle Cell Patients, and Non-Ischemic Priapism: An AUA/SMSNA Guideline – Journal of Urology

 


Cohort Study | ‘Weekend Warrior’ exercise pattern is associated with similar CVD benefits to regular activity

21 Jul, 2023 | 13:46h | UTC

Accelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease – JAMA (free for a limited period)

News Release: Researchers find ‘weekend warrior’ physical activity provides similar heart-related benefits as more regular exercise – Massachusetts General Hospital

Commentaries:

Good news for ‘weekend warriors’: people who do much of their exercise on a couple of days still get heart benefits – The Conversation

Weekend Warrior Physical Activity and Risk of Cardiovascular Disease – American College of Cardiology

 


Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19

21 Jul, 2023 | 13:43h | UTC

Potential “Healthy Vaccinee Bias” in a Study of BNT162b2 Vaccine against Covid-19 – New England Journal of Medicine

 

Commentary from the author on Twitter (thread – click for more)

 


RCT | MIND diet, a hybrid of Mediterranean and DASH, shows no superiority in preventing cognitive decline

21 Jul, 2023 | 13:38h | UTC

Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

‘MIND diet,’ intended to prevent dementia, doesn’t offer significant brain benefit, trial suggests – Live Science

Revised Mediterranean Diet Shows No Significant Impact on Cognition, MRI Outcomes in Older Persons – Neurology Live

 

Commentary on Twitter

 


RCT | Half-dose Tenecteplase + later PCI if indicated seems to be viable option in older individuals when timely PCI is unavailable

21 Jul, 2023 | 13:36h | UTC

Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction in STREAM-2: A Randomized, Open-Label Trial – Circulation (link to abstract – $ for full-text)

 

Commentary on Twitter

 


Phase 2 Trial | Maternal GBS6 vaccine shows promise in infant group B strep prevention

21 Jul, 2023 | 13:34h | UTC

Potential for Maternally Administered Vaccine for Infant Group B Streptococcus – New England Journal of Medicine

Commentary: Maternal strep B vaccine slashes risk of infection among infants – CIDRAP

 


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