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M-A | Oral isotretinoin and triple topical therapies found most effective in acne vulgaris treatment

26 Jul, 2023 | 13:13h | UTC

Comparative Efficacy of Pharmacological Treatments for Acne Vulgaris: A Network Meta-Analysis of 221 Randomized Controlled Trials – Annals of Family Medicine

News Release: Meta-analysis of research on acne reveals that oral isotretinoin, followed by topical antibiotic, benzoyl peroxide and retinoid, are most effective treatments – American Academy of Family Physicians

 

Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis

26 Jul, 2023 | 13:11h | UTC

Diagnostic management of acute pulmonary embolism: a prediction model based on a patient data meta-analysis – European Heart Journal (free for a limited period)

 

Commentary on Twitter

 

Review | Fluid management strategies and their interaction with mechanical ventilation: from experimental studies to clinical practice

26 Jul, 2023 | 13:08h | UTC

Fluid management strategies and their interaction with mechanical ventilation: from experimental studies to clinical practice – Intensive Care Medicine Experimental

 

New Cochrane handbook for systematic reviews of diagnostic test accuracy

25 Jul, 2023 | 14:02h | UTC

Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy – Cochrane Library

Editorial: Evaluating medical tests: introducing the Cochrane Handbook for Systematic Reviews of Diagnostic Test Accuracy – Cochrane Library

News Release: Introducing the new Cochrane Handbook for Diagnostic Test Accuracy – Cochrane Library

 

RCT | Vitamin D supplementation shows no cognitive benefit in mild cognitive impairment intervention

25 Jul, 2023 | 14:00h | UTC

Effects of Exercise Alone or Combined With Cognitive Training and Vitamin D Supplementation to Improve Cognition in Adults With Mild Cognitive Impairment: A Randomized Clinical Trial – JAMA Network Open

Commentary: Exercise and Cognitive Training Slow Thinking Declines. Vitamin D? Not So Much – HealthDay

Related:

RCT | No statistically significant impact of vitamin D on major cardiovascular events

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

 

Cohort Study | BMI of 25.0–29.9 not linked with higher mortality in 21st century U.S. adults

25 Jul, 2023 | 13:58h | UTC

Body mass index and all-cause mortality in a 21st century U.S. population: A National Health Interview Survey analysis – PLOS One

News Release: No increase in mortality for most overweight people, study finds – PLOS

Commentary: Expert reaction to study looking at BMI and all-cause mortality – Science Media Centre

 

Research Findings | US annual serious harms from misdiagnosis estimated at 795K in recent study

25 Jul, 2023 | 13:57h | UTC

Burden of serious harms from diagnostic error in the USA – BMJ Quality & Safety (link to abstract – $ for full-text)

News Release: Report Highlights Public Health Impact of Serious Harms From Diagnostic Error in U.S. – Johns Hopkins Medicine

Commentaries:

Majority of medical misdiagnoses occur in patients with less obvious disease manifestations – MedicalResearch

Misdiagnoses cost the U.S. 800,000 deaths and serious disabilities every year, study finds – STAT

 

Global, regional, and national burden of meningitis and its etiologies, 1990–2019

25 Jul, 2023 | 13:55h | UTC

Global, regional, and national burden of meningitis and its aetiologies, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019 – The Lancet Neurology

 

Commentary on Twitter

 

Consensus Paper | Urinary tract infections in pregnant individuals

25 Jul, 2023 | 13:53h | UTC

Urinary Tract Infections in Pregnant Individuals – Obstetrics & Gynecology

 

RCT | Dysphagia-optimized intensity-modulated radiotherapy better preserves swallowing function in pharyngeal cancer patients

25 Jul, 2023 | 13:52h | UTC

Dysphagia-optimised intensity-modulated radiotherapy versus standard intensity-modulated radiotherapy in patients with head and neck cancer (DARS): a phase 3, multicentre, randomised, controlled trial – The Lancet Oncology

Commentaries:

Dysphagia-Optimized vs Standard IMRT in Newly Diagnosed Patients With Head and Neck Cancer – The ASCO Post

Radiation approach improves swallowing in head, neck cancer – MDedge

 

Commentary on Twitter

 

Key factors associated with quality of postnatal care: a pooled analysis of 23 countries

25 Jul, 2023 | 13:50h | UTC

Key factors associated with quality of postnatal care: a pooled analysis of 23 countries – eClinicalMedicine

 

Cohort Study | Examining patient demographics, microbiology, and mortality in infectious endocarditis after TAVI

25 Jul, 2023 | 13:48h | UTC

Patient characteristics, microbiology, and mortality of infective endocarditis after transcatheter aortic valve implantation – Clinical Infectious Diseases

 

M-A | Early initiation of renal replacement therapy fails to improve survival rates in AKI patients

25 Jul, 2023 | 13:46h | UTC

Early strategy vs. late initiation of renal replacement therapy in adult patients with acute kidney injury: an updated systematic review and meta-analysis of randomized controlled trials – European Review for Medical and Pharmacological Sciences

 

Cohort Study | The role of antiphospholipid syndrome and specific antibodies in predicting SLE pregnancy complications

25 Jul, 2023 | 13:44h | UTC

Pregnancy outcomes in 1869 pregnancies in a large cohort from the Spanish Society of Rheumatology Lupus Register (RELESSER) – Seminars in Arthritis and Rheumatism (link to abstract – $ for full-text)

Commentary: SLE and Pregnancy Outcomes – RheumNow

 

Systematic Review | Rapamycin and rapalogs for tuberous sclerosis complex

25 Jul, 2023 | 13:43h | UTC

Rapamycin and rapalogs for tuberous sclerosis complex – Cochrane Library

 

Cohort Study | Association found between carpal tunnel syndrome and heart failure incidence

25 Jul, 2023 | 13:42h | UTC

Association Between Carpal Tunnel Syndrome and Subsequent Heart Failure Among Adults in Germany – JAMA Network Open

Commentary: Carpal Tunnel Syndrome Again Tied to Heart Failure: German Data – TCTMD

 

RCT | No significant impact of low-dose 0.01% atropine on myopia progression in children

25 Jul, 2023 | 13:40h | UTC

Low-Dose 0.01% Atropine Eye Drops vs Placebo for Myopia Control: A Randomized Clinical Trial – JAMA Ophthalmology (link to abstract – $ for full-text)

See also: Visual Abstract

Author Interview: Low-Dose 0.01% Atropine Eye Drops vs Placebo for Myopia Control – JAMA

Commentary: Atropine 0.01 Percent Eye Drops Do Not Slow Myopia Progression – HealthDay

Related:

RCT | 0.01% atropine effective in reducing progression of myopia in children over 3 years

RCT | Effect of repeated low-level red light on myopia prevention among children in China with premyopia

Efficacy of atropine for myopia control in children: A meta-analysis of randomized controlled trials – Journal of Family Medicine and Primary Care

Interventions for myopia control in children: a living systematic review and network meta‐analysis – Cochrane Library

RCT | Effect of low-concentration atropine eyedrops vs. placebo on myopia incidence in children

Crossover RCT | Spectacle lenses with highly aspherical lenslets for slowing myopia.

RCT | Effect of text messaging parents of school-aged children on outdoor time to control myopia.

RCT | Myopia control effect of repeated low-level red-light therapy in children.

RCT: Spectacle lenses with aspherical lenslets for myopia control vs. single-vision spectacle lenses.

Randomized trial: Effect of High add power, medium add power, or single-vision contact lenses on myopia progression in children

 

M-A | Early NIPPV likely reduces the risk of respiratory failure and intubation in very preterm infants

25 Jul, 2023 | 13:39h | UTC

Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure (NCPAP) for preterm infants – Cochrane Library

 

Systematic Review | Existing research on post-stroke depression interventions lacks conclusive results

25 Jul, 2023 | 13:37h | UTC

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating depression after stroke – Cochrane Library

Summary: Pharmacological, non-invasive brain stimulation and psychological interventions for treating depression after stroke – Cochrane Library

 

Phase 2 Trial | The addition of immunotherapy to stereotactic ablative radiotherapy may enhance EFS in early-stage NSCLC

25 Jul, 2023 | 13:36h | UTC

Stereotactic ablative radiotherapy with or without immunotherapy for early-stage or isolated lung parenchymal recurrent node-negative non-small-cell lung cancer: an open-label, randomised, phase 2 trial – The Lancet (link to abstract – $ for full-text)

 

Systematic Review | Post-mastectomy RT likely lowers recurrence and improves survival in early breast cancer with 1-3 positive nodes

25 Jul, 2023 | 13:34h | UTC

Post‐mastectomy radiotherapy for women with early breast cancer and one to three positive lymph nodes – Cochrane Library

Summary: Is X-ray treatment (radiotherapy) after removal of breast tissue (mastectomy) better than no X-ray treatment in women diagnosed with breast cancer that has spread to one to three armpit lymph nodes? – Cochrane Library

 

M-A | Comparison of systemic treatments for chronic plaque psoriasis – Anti-IL17 stands out

25 Jul, 2023 | 13:27h | UTC

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta‐analysis – Cochrane Library

 

Systematic Review | Moderate evidence supports interactive mobile phone interventions for contraception use enhancement

25 Jul, 2023 | 13:25h | UTC

Mobile phone‐based interventions for improving contraception use – Cochrane Library

 

New WHO guidance on the role of HIV viral suppression in improving individual health and reducing transmission

24 Jul, 2023 | 13:17h | UTC

News Release: New WHO guidance on HIV viral suppression and scientific updates released at IAS 2023 – World Health Organization

WHO Guidance: The role of HIV viral suppression in improving individual health and reducing transmission – Word Health Organization

Related WHO Guidelines:

WHO recommends optimizing HIV testing services – World Health Organization

Primary health care and HIV: convergent actions – World Health Organization

 

Systematic Review | Low-level HIV viremia (below 1000 copies/mL) linked to minimal sexual transmission risk

24 Jul, 2023 | 13:15h | UTC

The risk of sexual transmission of HIV in individuals with low-level HIV viraemia – The Lancet

Editorial: HIV is sexually untransmittable when viral load is undetectable – The Lancet

Related: Study: Growing Acceptability of “Undetectable = Untransmittable” but Widespread Misunderstanding of HIV Transmission Risk Persists (several texts on the subject)

 

Commentary on Twitter

 

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